HHS discontinues committees focusing on newborn health screening

Secretary Robert F. Kennedy Jr. of the Department of Health and Human Services has committed to improving the health of Americans, with a particular emphasis on reducing health burdens among children. Despite this, the department recently removed the Advisory Committee on Newborn and Child Genetic Disorders.

For the past 15 years, the Advisory Committee on Hereditary Disorders in Newborns and Children has played a crucial role in recommending which conditions should be included in the universal screening panel for newborns to the health and human services secretaries.

Kennedy’s focus has been on tracing the origins of a broader spectrum of pediatric diseases such as autism, asthma, and obesity, but rare diseases, mostly genetic, remain a significant public health concern. In the United States, around 15 million children have rare diseases, most of which are genetic.

Screenings of newborns identify about 14,000 babies each year with potentially life-threatening conditions, according to the National Agency for Rare Disability (NORD). Early diagnosis at birth provides parents with valuable intervention opportunities, usually most effective before symptoms manifest.

While individual states determine which conditions to screen for, most follow the federally recommended uniform screening panel. Volunteer scientists and medical professionals on the advisory board primarily shape the screening panel with their recommendations.

Allison Herrity, senior policy analyst at NORD, expressed disappointment at the dissolution of the committee and its impact on the process of adding new conditions to the screening panel.

The Internal HHS email reviewed by NBC News confirmed the abrupt end of the committee on April 3, without any explanation. This decision has left room for speculation and hope that the committee may be reinstated to address the pressing need for identifying and treating rare genetic disorders in newborns.

Dr. Sean McCandless, Director of Genetics and Metabolism at Colorado Children’s Hospital, emphasized the importance of early diagnosis and treatment, especially for conditions like MLD and DMD, which have available therapies to improve patients’ quality of life.

However, the removal of the advisory committee poses a threat to the inclusion of new conditions in the Universal Panel. Without a structured approach like the committee, ensuring comprehensive and evidence-based screening for new conditions becomes challenging.

McCandless and other healthcare professionals have appealed to Kennedy to reinstate the advisory board to align with his vision of a healthier America. Advocates are concerned about the future of universal screening and fear disparities between states in offering comprehensive screenings.

They stress the importance of an independent body like the advisory committee to ensure that screening recommendations are based on scientific evidence rather than external influences.

There is a call for a more streamlined process for adding conditions to the screening panel to keep pace with advancements in treatments and medical knowledge, ultimately benefiting children and families affected by rare genetic disorders.

Source: www.nbcnews.com

HHS discontinues research on vaccines and treatments for potential pandemics

The Trump administration has cancelled funds for dozens of research seeking new vaccines and treatments for Covid-19 and other pathogens that could cause a future pandemic.

The government’s rationale is that, according to internal NIH documents viewed by the New York Times, the community’s pandemic has ended and “provides a cause for the end of COVID-related grants.”

However, the research was not merely about Covid. 9 finished Award-funded center We will conduct research on antiviral drugs to combat so-called priority pathogens that could create an entirely new pandemic.

“This includes anti-viral projects designed to cover a wide range of families that could cause outbreaks or pandemics,” said a senior NIH official who spoke on condition of anonymity for fear of retaliation.

Vaccine research also didn’t focus on Covid, but on other coronaviruses that would one day jump from animals to humans.

Describing all studies as COVID-related is “completely inaccurate and merely a way to reduce infectious disease research,” officials said. Health Secretary Robert F. Kennedy Jr. said the NIH is focusing too much on infections, officials noted.

The funding suspension was first reported Science and Nature. The cancellation surprised scientists who relied on government support.

“The idea that there’s no need for further research to learn how to treat health issues caused by the coronavirus and prevent future pandemics is because “Covid-19 is over” is ridiculous,” says Pamela Bjorkman, a structural biologist at Caltech, who was studying the new vaccine.

The goal of the project was to prepare vaccines and drugs if a new pandemic hits it, rather than developing valuable months from scratch.

“In the last pandemic, we were really knocking down our pants,” said Paul Vienias, a virologist at Rockefeller University, working with Dr. Bjorkman.

“And unless you learn that lesson and prepare better for the next pandemic, you’ll rarely do better than last time.”

Dr. Beanius, Dr. Bjorkman and his colleagues were developing a vaccine that could protect them from a wide range of coronavirus species.

Researchers have discovered new strategies for caxing the immune system and learned how to recognize molecular features common to one or more viruses. The results of animal experiments were promising.

But now, their funds have been cut suddenly, and scientists say they doubted they could build on those outcomes. Dr. Vienias said the fire made him “angry, disappointed and frustrated.”

Other scientists were working on antiviral therapy, part of a program launched in 2021.

$577 million With support from the NIH, the lab’s nationwide network was studying how the virus was replicated and searching for drugs that could block them.

The researchers focused on the Viridae family, which contains the most worrying known pathogens, such as Ebola and Nipah virus. Scientists discovered many promising molecules and were moving forward towards clinical trials.

Reuben Harris, a molecular virologist at UT Health San Antonio, said the promising compounds revealed by the program include antiviral drugs that stop Ebola-related viruses from entering cells.

“We can deploy to help a lot of people quickly,” Dr. Harris said.

Several compounds appeared to work against many viral families. “We’ve seen a lot of experience in the world,” said Nevan Krogan, a systems biologist at the University of California, San Francisco.

On Wednesday morning, Dr. Krogan and dozens of colleagues gathered in the campus meeting room to confirm their results. And they also discussed what they could now, if any.

“One student asked me, ‘Well, I booked an experiment with this microscope tomorrow – can I do that?” “And I’m like, ‘Well, I don’t know.’ ”

Dr. Harris said that without ongoing support, the promising drugs he and others have discovered will not move into clinical trials. “It’s tragic – I don’t have too many words to explain it now,” he said.

In 2023, Kennedy said he wanted to take it. “break” From infectious disease research, instead focuses on chronic diseases.

Jason McClellan, a virologist at the University of Texas at Austin, was working on an antiviral drug program, but saw cancellations of pandemic research follow that promise.

Dr. McClellan, whose previous research was based on the creation of the 2020 Covid vaccine, said this week’s cuts made him wonder whether he could continue to study the pandemic in the United States.

“We’re starting to have conversations and plan to gather more information,” he said, noting the possibility of moving abroad.

“My lab is a structural virology lab focused on structural-based vaccine design,” he added. “If the focus is on chronic diseases, it doesn’t leave us much of a funding.”

Source: www.nytimes.com

McDonald’s discontinues AI drive-thru trial as fast food industry explores automation

McDonald’s has terminated its trial of an artificial intelligence chatbot in its drive-thrus, sparking concerns about the fast-food industry’s hasty adoption of this technology.

The largest burger chain in the world is removing its AI-based automated ordering system from over 100 restaurants throughout the US.

This system, capable of responding to customer orders using AI voice, was undergoing testing under a contract between McDonald’s and IBM that began in 2021.

McDonald’s has not specified the reasons for ending the trial. As reported by Restaurant Business, the company informed franchisees that the technology would be discontinued on July 26th.

A McDonald’s spokesperson mentioned to the publication that a decision regarding automated ordering plans would be made by year-end, emphasizing that “voice ordering solutions at the drive-thru are part of our restaurants’ future.”

Fast-food chains have displayed considerable interest in incorporating generative AI into their operations in recent years. Apart from McDonald’s, various companies such as Wendy’s, Hardee’s, Carl’s Jr., and Del Taco have implemented this technology in their drive-thrus. Yum! Brands, the owner of Taco Bell and KFC, also declared its adoption of AI earlier this year. “AI First Mindset” at a fast food restaurant.

The fast-food industry is increasingly receptive to AI as a substitute for human workers, aiding in reducing escalating labor costs. Following California’s enactment of a new minimum wage regulation for fast-food employees, companies are hastening the integration of AI technology to handle tasks like taking customer orders.

While companies promote AI as the future of the fast-food industry, these technologies have been featured in viral videos and covered in the media when orders go awry. McDonald’s drive-thru AI blunder became viral last year after several TikTok videos showcased the system incorrectly adding items, such as butter packs, or doubling the order quantities.

In one video, two women were captured laughing and requesting the system to cease adding items to their order, as it appeared to tally hundreds of dollars’ worth of McNuggets to their bill.

Automated systems have faced criticism for misinterpreting customer orders, as well as for depending on outsourced human labor for their operation. Presto Automation, which supplies AI services to fast-food chains, disclosed in an SEC filing last year that it employs customer-facing staff in countries like the Philippines, who spend around 70% of their time there.

In addition to drive-thru ordering, companies are exploring leveraging generative AI for creating digital chatbots on their apps or utilizing image recognition for estimating wait times.

In December, McDonald’s partnered with Google to develop a chatbot named “Ask Pickles” for guiding employees on tasks like cleaning restaurant equipment. The collaboration also encompasses exploring other potential applications of generative AI. As per Bloomberg’s report.

Source: www.theguardian.com

Google quietly discontinues popular apps as part of restructuring efforts

Google is removing popular apps in a new shake-up within the company.

The Google Play Movies & TV app will be retired soon.

The service has already been removed from Roku devices and most smart TVs, and over the next few weeks, Google plans to continue shutting down the service until it’s gone completely. It’s still available on Android TV and the Google Play Store, but not for much longer.

“We’re making several changes to simplify the way you buy new movies and access the movies and TV shows you buy through Google,” the company said in a statement. Posted in support thread Android TV Help.

Starting January 17th, users will no longer be able to access content through Play Movies & TV. But don’t worry, your rented or purchased movies won’t be lost forever. All your purchased movies and TV will be transferred to Android TV and YouTube.

“As a result of these changes, Google Play Movies & TV will no longer be available on Android TV devices or the Google Play website,” Google explained. “However, you will still have access to all previously purchased titles (including active rentals) on Android TV devices, Google TV devices, the Google TV mobile app (Android and iOS), and YouTube.”

The tech giant has been slowly discontinuing its Play Movies & TV app since launching a standalone TV app in 2021.


Starting January 17th, users will no longer be able to access content through Play Movies & TV. Daniel Krassoa – Stock.adobe.com

When this change takes effect on January 17th, people with Android TV-powered TVs or streaming devices will be able to watch previously purchased titles or purchase new movies from the Shop tab. Purchased titles and active rentals will be displayed.

On a cable box or set-top box with Android TV, the YouTube app stores all your previously purchased content. YouTube is also the new content home for people using web browsers.

These changes come on the heels of Google removing inactive Gmail accounts in a cybersecurity effort and introducing an AI-powered makeover with five new features.

Source: nypost.com