New modeling studies suggest that ratios of potassium to sodium intake can help regulate blood pressure

Excessive dietary sodium increases blood pressure, while a high potassium diet has the opposite effect. The underlying mechanism is alleviated by sex and includes multiple organs and tissues. How do high potassium-induced alternatives in renal function differ between men and women with lower blood pressure? To answer these questions, a duo of researchers at the University of Waterloo conducted computer simulations to simulate the homeostasis of whole body fluids and electrolytes, simulating the effects of sodium and potassium intake on blood pressure.

Melissa Stadt & Anita Layton suggests that increasing the ratio of dietary potassium to sodium intake may be more effective in lowering blood pressure than simply reducing sodium intake. Image credit: Melissa Stadt & Anita Layton, doi: 10.1152/ajprenal.00222.2024.

Hypertension affects more than 30% of adults around the world. It is the main cause of coronary heart disease and stroke, and can lead to other distress such as chronic kidney disease, heart failure, irregular heartbeat, and dementia.

“We usually recommend eating less salt when we have high blood pressure,” said Professor Anita Leighton, author of the study.

“Our research suggests that adding potassium-rich foods to a diet such as bananas and broccoli can have a greater impact on blood pressure than cutting off sodium.”

Potassium and sodium are both electrolytes, which help the body send electrical signals to contract muscles, affect the amount of water in the body, and perform other essential functions.

“Early humans ate a lot of fruits and vegetables. As a result, our body’s regulatory system may have evolved to work best on a high potassium, low sodium diet.”

“Today, Western diets tend to be much higher in sodium and lower in potassium.”

“It may explain why hypertension is seen primarily in industrialized societies, not isolated societies.”

Previous studies found that increased potassium intake helps control blood pressure, but researchers have developed a mathematical model that successfully identifies how potassium-sodium ratios affect the body.

The model also identifies how sex differences affect the relationship between potassium and blood pressure.

Scientists have found that men develop hypertension more easily than premenopausal women, but men are more likely to respond positively to an increased potassium-to-sodium ratio.

“Mathematical models like those used in this study allow these types of experiments to identify how different factors affect the body quickly, cheaply, and ethically,” they said.

Team’s paper Released in March 2025 American Journal of Physiology-Renal Physiology.

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Melissa Statt and Anita T. Leighton. Regulation of blood pressure by dietary potassium and sodium: Gender differences and modeling analysis. American Journal of Physiology-Renal PhysiologyPublished online on March 3, 2025. doi: 10.1152/ajprenal.00222.2024

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Scientists witness uncommon nuclear decay of potassium isotope

Physicists are Potassium Decay (KDK) Collaboration. They directly observed for the first time a very rare but important decay pathway from potassium-40 to argon-40. Their results have the potential to improve current understanding of physical processes and increase the accuracy of geological dating.

Decay scheme of potassium 40. Image credit: Stukel other., doi: 10.1103/PhysRevLett.131.052503.

Potassium-40 is a ubiquitous natural isotope whose radioactivity has been used to estimate geological ages over billions of years, to theories of nuclear structure, and to the search for subatomic rare events such as dark matter and neutrinoless double beta decay. influence.

The decay of this long-lived isotope must be precisely known for its use as a global clock and to explain its presence in low-background experiments.

Although potassium-40 has several known decay modes, the electron-capture decay predicted directly into the ground state of argon-40 has never been observed before.

“Some of the nuclei of certain elements radioactively decay into the nuclei of other elements. These decays can be helpful or annoying, depending on the situation,” the KDK physicists said. I am.

“This is especially true for potassium-40, an isotope that normally decays to calcium-40, but about 10% of the time it decays to argon-40.”

“This decay pathway involves a process called electron capture, which provides information about the nuclear structure.”

“Potassium-40 has a very long half-life, so it can even determine the age of geological objects on billion-year time scales.”

“Due to its long half-life, it is difficult to find another way for potassium-40 to break down.”

In a new study, researchers measured a rare decay branch of potassium-40 at Oak Ridge National Laboratory's Holyfield Radioactive Ion Beam Facility.

“Quantifying the decay rate of potassium-40 and its decay branches is difficult because it requires measuring the parent nucleus and a sufficient number of rare progeny nuclei,” the researchers said.

“We studied a subset of potassium-40 that decays to argon-40 by electron capture, which accounts for about 10% of all potassium-40 decays.”

“Although most potassium-40 electron-capture decays emit characteristic gamma rays that form the background of most experiments, a small subset of these decays occur without gamma ray emission.”

“This happens when potassium-40 captures an electron that goes directly to the ground state of argon-40.”

“We have directly measured this decay for the first time. This result indicates that other decay rates may also need to be reevaluated.”

“The rare decay branch we identified and measured provides unique experimental evidence for so-called forbidden beta decay, with implications for predictions of nuclear structure and for potassium-based geological and solar system age estimates. It removes years of uncertainty.”

“This discovery also improves our assessment of the background that exists in experiments that explore new physics beyond the Standard Model.”

The results are published in two papers (paper #1 and paper #2) in the diary physical review letter and diary Physical Review C.

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M. Stukel other. (KDK collaboration). 2024. 40,000 rare collapses with implications for fundamental physics and geochronology. Physics.pastor rhett 131 (5): 052503; doi: 10.1103/PhysRevLett.131.052503

L. Harias other. (KDK collaboration). 2024. Evidence of ground state electron capture at 40K. Physics. Rev.C 108 (1): 014327; doi: 10.1103/PhysRevC.108.014327

Source: www.sci.news