A highly skilled meditator dedicated 15 years to mastering ego quieting techniques. Recent brain scans reveal that he may have achieved a similar state using low doses of psychedelic substances.

According to Christopher Timmerman from University College London, “At low doses, there appears to be significant alignment in brain activity between this psychedelic state and non-dual meditation practices,” a meditative form that transcends the self-world distinction.

The field of psychedelic research is rapidly evolving, as scientists seek to explore how substances like 5-MeO-DMT can enhance consciousness and mental well-being. Notably derived from North American toads, 5-MeO-DMT is under scrutiny due to its unique effects: Rapid disruption of mental processing without vivid hallucinations.

Timmerman and his team undertook a study comparing the psychedelic state induced by 5-MeO-DMT with advanced meditative practices. Collaborating with lamas from the Karma Kagyu school of Tibetan Buddhism, they recorded over 54,000 hours of meditation.

In a controlled setting, the lamas practiced meditation for 30 to 60 minutes, followed by either a placebo or low/high doses of 5-MeO-DMT. Brain activity was measured throughout these conditions, and post-session reflections on thoughts and self-perception were recorded.

They discovered that low doses (5 milligrams) of 5-MeO-DMT produced notable parallels in brain activity to meditative states. Scans indicated increased alpha activity, associated with a relaxed state of wakefulness, and reduced gamma activity linked to cognitive engagement, compared to both placebo and baseline conditions.

Timmerman pointed out that while both scenarios offer a calming effect where the lama’s thoughts “came and then vanished,” meditation provided a deeper sense of interconnectedness and mental clarity.

Higher doses (12 milligrams) of 5-MeO-DMT, however, boosted gamma activity. The lama described feelings of complete detachment from his surroundings, overwhelmed by intense white light. “I’m not thinking about anything,” he recounted, experiencing full disconnection from his body and environment.

This elevated dose also correlated with increased neuronal firing and entropy, indicating more unpredictable firing patterns compared to both placebo and baseline sessions, thus overwhelming his sensory perceptions. Conversely, lower doses resulted in decreased neuronal firing and entropy.

The research findings suggest a connection between different neural pathways, relating to the “collapse of the ego” and the sensation of “contentless consciousness.” However, changes in the lama’s brain activity do not necessarily account for his subjective experiences, as noted by Matthew Sachet from Harvard Medical School.

It’s essential to note that this study involved only one highly skilled meditator, potentially limiting the broader applicability of results, particularly as brain activity assessments can offer varying reliability. Additionally, blinding participants in psychedelic studies presents challenges due to the typical side effects of these substances, which can alert participants to their experience. Fortunately, no such effects were reported by the lamas.

Nonetheless, Timmerman emphasizes that if further research confirms the safe usage of 5-MeO-DMT can deliver comparable advantages to advanced meditation, the implications could benefit a wider audience. He is currently investigating whether this substance can expedite the learning curve for novice meditators, cautioning against unsupervised use, especially since 5-MeO-DMT remains illegal in several regions.

Meanwhile, Sachet posits that for individuals seeking mental health benefits from 5-MeO-DMT, meditation might provide “a viable path to a state that overlaps, at least partially, with some psychedelic effects,” sans the associated risks of toxicity or addiction.