Unlocking Clarity: How Psychedelic 5-MeO-DMT Mimics Meditation Brain States

Meditation and 5-MeO-DMT Research

Meditation and Low Doses of 5-MeO-DMT Induce Similar Effects

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A master meditator dedicated 15 years to mastering ego quieting. Brain scan studies indicate he may have utilized powerful psychedelics to attain an altered state.

“At low doses, there’s a significant overlap in brain activity between this psychedelic and non-dual meditative states,” explains Christopher Timmerman of University College London.

The realm of psychedelic research is expanding rapidly, revealing how substances like 5-MeO-DMT can enhance our understanding of consciousness and improve mental health. This compound, often sourced from North American toads, is particularly compelling due to its ability to rapidly disrupt mental processing without producing vivid visuals like other psychedelics.

Timmerman and his team conducted a detailed comparison between the altered states induced by 5-MeO-DMT and advanced meditation. They collaborated with lamas, experts in the Karma Kagyu tradition of Tibetan Buddhism, amassing over 54,000 hours of meditation data.

During three laboratory sessions, lamas meditated for 30 to 60 uninterrupted minutes, followed by either a placebo or varying doses of 5-MeO-DMT (5 or 12 milligrams). Their brain activity was meticulously measured during each scenario, alongside reports on their thoughts and sense of self post-session.


Findings revealed that low doses of 5-MeO-DMT (5 milligrams) created remarkable similarities in brain patterns to those observed during meditation. Both scenarios exhibited heightened alpha activity, which is often linked to a relaxed state, and a diminished response to external stimuli compared to placebo and baseline conditions. Gamma-ray activity, which relates to cognitive engagement, was also reduced.

Timmerman noted that while both experiences fostered a calm feeling where the lama’s thoughts “came and then vanished,” the meditative state offered a deeper sense of interconnectedness and mental clarity.

In contrast, higher doses (12 milligrams) of 5-MeO-DMT escalated gamma-ray activity, leaving the lama feeling entirely detached from his surroundings and even experiencing an overwhelming bright light. He remarked, “I’m not thinking about anything,” indicating a complete disconnect from awareness of his body and environment.

The higher dosage was linked to increased neuronal firing and entropy, suggesting overwhelming sensory input compared to both placebo and baseline conditions. Conversely, lower doses resulted in decreased neuronal firing and entropy.

Lama Records Brain Activity During Meditation

Christopher Timmerman

Researchers state that these findings are pivotal in connecting neural pathways to the “collapse of the ego” and the sensation of “contentless consciousness.” However, variations in brain activity do not fully capture the lama’s subjective experiences, acknowledges Matthew Sachet from Harvard Medical School.

This study focused on a single seasoned meditator, indicating potential limitations in broader applicability, particularly given the variability in brain activity-related studies. Additionally, ensuring participants are blinded in psychedelic studies poses challenges due to the identifiable side effects of psychedelics; fortunately, lamas reported no such effects.

Nonetheless, Timmerman asserts that if future research confirms safe integration of 5-MeO-DMT enhances the benefits of advanced meditation, it may have significant implications for a wider audience. He is conducting ongoing research to explore if the drug can facilitate faster progress for newbies to meditation but strongly advises against unregulated home use, as 5-MeO-DMT remains illegal in many jurisdictions.

Meanwhile, Sachet suggests that those seeking the mental health advantages attributed to 5-MeO-DMT might find meditation a practical alternative, offering overlapping experiences without the risks of toxicity or addiction.

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Source: www.newscientist.com

Psychedelics Create Brain States Comparable to Meditation in Spiritual Lamas

Meditation and Low Doses of 5-MeO-DMT: Comparable Effects on Spiritual Experiences

Janique Bros/Getty Images

A highly skilled meditator dedicated 15 years to mastering ego quieting techniques. Recent brain scans reveal that he may have achieved a similar state using low doses of psychedelic substances.

According to Christopher Timmerman from University College London, “At low doses, there appears to be significant alignment in brain activity between this psychedelic state and non-dual meditation practices,” a meditative form that transcends the self-world distinction.

The field of psychedelic research is rapidly evolving, as scientists seek to explore how substances like 5-MeO-DMT can enhance consciousness and mental well-being. Notably derived from North American toads, 5-MeO-DMT is under scrutiny due to its unique effects: Rapid disruption of mental processing without vivid hallucinations.

Timmerman and his team undertook a study comparing the psychedelic state induced by 5-MeO-DMT with advanced meditative practices. Collaborating with lamas from the Karma Kagyu school of Tibetan Buddhism, they recorded over 54,000 hours of meditation.

In a controlled setting, the lamas practiced meditation for 30 to 60 minutes, followed by either a placebo or low/high doses of 5-MeO-DMT. Brain activity was measured throughout these conditions, and post-session reflections on thoughts and self-perception were recorded.

They discovered that low doses (5 milligrams) of 5-MeO-DMT produced notable parallels in brain activity to meditative states. Scans indicated increased alpha activity, associated with a relaxed state of wakefulness, and reduced gamma activity linked to cognitive engagement, compared to both placebo and baseline conditions.

Timmerman pointed out that while both scenarios offer a calming effect where the lama’s thoughts “came and then vanished,” meditation provided a deeper sense of interconnectedness and mental clarity.

Higher doses (12 milligrams) of 5-MeO-DMT, however, boosted gamma activity. The lama described feelings of complete detachment from his surroundings, overwhelmed by intense white light. “I’m not thinking about anything,” he recounted, experiencing full disconnection from his body and environment.

This elevated dose also correlated with increased neuronal firing and entropy, indicating more unpredictable firing patterns compared to both placebo and baseline sessions, thus overwhelming his sensory perceptions. Conversely, lower doses resulted in decreased neuronal firing and entropy.

Lama Recording Brain Activity During Meditation

Christopher Timmerman

The research findings suggest a connection between different neural pathways, relating to the “collapse of the ego” and the sensation of “contentless consciousness.” However, changes in the lama’s brain activity do not necessarily account for his subjective experiences, as noted by Matthew Sachet from Harvard Medical School.

It’s essential to note that this study involved only one highly skilled meditator, potentially limiting the broader applicability of results, particularly as brain activity assessments can offer varying reliability. Additionally, blinding participants in psychedelic studies presents challenges due to the typical side effects of these substances, which can alert participants to their experience. Fortunately, no such effects were reported by the lamas.

Nonetheless, Timmerman emphasizes that if further research confirms the safe usage of 5-MeO-DMT can deliver comparable advantages to advanced meditation, the implications could benefit a wider audience. He is currently investigating whether this substance can expedite the learning curve for novice meditators, cautioning against unsupervised use, especially since 5-MeO-DMT remains illegal in several regions.

Meanwhile, Sachet posits that for individuals seeking mental health benefits from 5-MeO-DMT, meditation might provide “a viable path to a state that overlaps, at least partially, with some psychedelic effects,” sans the associated risks of toxicity or addiction.

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Source: www.newscientist.com