Lung Association finds that 131 million Americans live in areas with unhealthy pollution levels

Nearly 40% of Americans live in areas with unhealthy levels of air pollution, and the U.S. is set to regress in air-cleaning progress as the effects of climate change intensify, according to a new report from the American Lung Association. It’s coming. The group’s report, its 25th annual analysis of the nation’s “state of the air,” estimates that between 2020 and 2022, 131 million people will live in areas with unhealthy levels of air pollution. It turned out that it was. This number is an increase of nearly 12 million people from the previous survey a year ago. The report also found that people in the United States are experiencing the most “very unhealthy” or “hazardous” air quality day in the study’s history. Katherine Pruitt, national senior director of clean air policy at the American Lung Association, said the process has been in place for decades through the Clean Air Act, a federal law passed in 1963 to regulate air pollution and set air quality standards. He said that the cleanup efforts that have been made are gradually being undermined by climate change.

“Climate change, including heat, drought and especially wildfires, is starting to undo some of the progress we’ve made,” Pruitt said. “It’s sad to know that so many people live with air quality that threatens their health.” Wildfires are a rapidly growing source of pollution that policymakers are struggling to address. Climate scientists predict that wildfire smoke will increase in the future as greenhouse gas emissions raise temperatures. The Lung Association’s analysis reached the same conclusion as a peer-reviewed study published last year in Nature. The study’s author, Marshall Burke, suggested that wildfire smoke has undone about 25% of the Clean Air Act’s progress.

“If you take a step back and think about what the root cause is, it’s the burning of fossil fuels,” says Dr. Lisa Patel, a pediatrician and clinical associate professor at Stanford Medicine Children’s Health. “We don’t have to be in this situation. We have the technology and the federal investment to harness renewable energy. What we need now is the political will.”

Each year, the “State of the Air” report analyzes air quality data from the past three years. This analysis focuses on ozone exposure and short-term and annual exposure to particulate pollution. The report issues a rating for each measure and summarizes the number of areas that passed or failed for each rating. According to the report, nearly 44 million people currently live in areas that do not meet all three criteria.Small particles are a serious concern because they can enter a person’s lungs, circulate in the bloodstream, and affect other organs. Although these particles are only a fraction of the size of a human hair, they have been shown to increase the risk of asthma, lung cancer, chronic lung disease, premature birth, and miscarriage. Patel, who is also executive director of the Medical Societies Consortium on Climate and Health, has noticed an increase in preterm births during wildfire seasons and is educating parents about how heat and smoke are risk factors during pregnancy. He said he has started giving advice.

“After several weeks of poor air quality, more people will become pregnant and give birth before 37 weeks,” Patel said, adding that parents may wonder whether their actions led to premature birth. He added that he often thinks about this. “When people ask me about the risk of premature birth, I say climate change. Heat and wildfires are both risk factors. They are not within your control.” Additionally, Patel said she has noticed that when wildfire smoke incidents occur in California, patients at her pediatric clinic often complain of nasal infections, eye irritation, and asthma exacerbations, among other ailments. Pruitt said concerns about particle pollution used to be concentrated in the industrial Midwest and Northeast. But in this report, for the first time, all 25 cities with the highest daily particle pollution are in the West. Most were in California.

“Early in our history, we had a lot of particulate pollution coming from coal-fired power plants, transportation sources, and industrial processes,” Pruitt said. “Particle pollution problems in the eastern United States are less severe because the Clean Air Act has cleaned up these sources. But Western countries, of course, have similar access to regulation and cleanup; We are also affected by climate change and wildfires.” Daniel Mendoza, an assistant professor of atmospheric science at the University of Utah, said many communities in Western states are dealing with acute, short-term pollution episodes rather than long-term chronic exposure. Scientists are still trying to figure out how much damage wildfire outbreaks cause compared to long-term exposure from industrial sources. “Not all bad air pollution is created equal,” Mendoza said. Pollution from traffic and industrial sources could continue to decline if the Environmental Protection Agency’s proposed stricter standards could be implemented.

Last year, the EPA proposed a rule that would require nearly all coal and large gas plants in the country to reduce or capture about 90% of their carbon emissions by 2038. In March this year, the agency introduced stricter rules to reduce tailpipe emissions from passenger cars. Another EPA policy aimed at curbing nitrogen oxide pollution that spreads across states was challenged in the U.S. Supreme Court. In 2022, the Supreme Court limited the government’s ability to use the Clean Air Act to reduce greenhouse gas emissions. There is one bright spot in this report. That means ozone pollution continues to improve dramatically. Compared to last year, about 2.4 million fewer people live in areas with unhealthy ozone pollution. Since this analysis was completed, wildfire smoke has gotten even worse.

Americans in 2023 inhaled more wildfire smoke than in any other year on record, Stanford University researchers found last year.

Source: www.nbcnews.com

UK AI Safety Association: Setting Standards, Not Tests, is Essential for Artificial Intelligence Safety

The UK should prioritize setting global standards for artificial intelligence testing, instead of attempting to conduct all reviews itself, as suggested by the company responsible for the government’s AI Safety Institute.

Mark Warner, CEO of Faculty AI, emphasized the institute’s commitment to AI safety and its development of technologies for chatbots like ChatGPT. He cautioned that excessive scrutiny of AI models could be limiting.

Last year, Rishi Sunak announced the establishment of the AI Safety Institute (AISI) ahead of a global AI safety summit. This initiative involved collaboration with large tech companies from the EU, UK, US, France, and Japan to prioritize testing of advanced AI models before and after deployment.

The UK’s leading role in AI safety was underscored by the establishment of the Institute, according to Warner, whose London-based company also works with a British lab to test AI model compliance with safety guidelines.

Warner stressed the importance of the institute becoming a global leader in setting testing standards: “I think it’s important to set standards for the wider world rather than trying to do everything ourselves,” he said.

He also expressed optimism about the institute’s potential as an international standard setter, promoting scalability in maintaining AI security and describing it as a long-term vision.

Warner cautioned against the government taking on all testing responsibilities, advocating for the development of standards that other governments and companies can adopt instead.

He acknowledged the challenge of testing every released model and suggested focusing on the most advanced systems.

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The Financial Times reported that major AI companies are urging the UK government to expedite safety testing of AI systems. Notably, the US also announced the establishment of an AI Safety Institute participating in the testing program outlined at the Bletchley Park summit.

The UK’s Department for Science, Innovation and Technology emphasized the role of governments in testing AI models, with the UK taking a leading global role through the AI Safety Institute.

Source: www.theguardian.com

Hippocampal Taurine Levels Decrease by 20% in Association with Depression

A groundbreaking study by South Korean researchers has revealed a link between lower levels of taurine in the hippocampus and depression in young women. This discovery, using 7T MRI technology, opens new avenues in the treatment and understanding of depression and highlights the importance of taurine in brain health. Credit: SciTechDaily.com

Precise observation using ultra-high magnetic field 7T MRI. A South Korean research team has discovered for the first time that there is a significant relationship between depression and taurine levels in the hippocampus, an area of the brain responsible for memory and learning functions. This discovery provides an opportunity to promote the role and importance of taurine in the prevention, diagnosis, and treatment of depression in the future. (source)

Advanced imaging technology reveals important insights. Researchers from the Korea Basic Science Institute (KBSI, Director Sung-kwan Yang) biochemical analysis team (Dr. Young-kyu Song, Dr. Ji-hyun Cho, and Dr. Chae-joon Jeong) used ultra-high magnetic field 7T human MRI (7T MRI). (source)

The study was conducted in collaboration with a research team led by Dr. Kim Hyun-jun from the Korea Institute of Oriental Medicine (KIOM) and Professor Song Jin-hoon from Chungnam University (CNU), and compared two groups of female participants. It is, a group of 36 female patients with major depressive disorder, and a control group of 40 healthy women. All participants were between 19 and 29 years old. (source)

(A) Brain regions where spectra were measured (yellow box) (B) 1H MR spectrum of the hippocampus: taurine signal in the hippocampus shown at 3.4 ppm (arrow). Black line: actually measured spectrum. Red line: LCModel fitting spectrum. Credit: Korea Basic Science Institute (KBSI)

Global impact of depression. Depression is an illness that causes serious damage and loss, not only personally, but also socially and economically. According to the World Health Organization (WHO), more than 260 million people worldwide suffer from depression, and more than 800,000 people take their own lives each year. (source)

What is taurine? Taurine is an aminosulfonic acid acid unlike most others, amino acid, does not build proteins. Instead, it plays several important roles in the body. It is naturally present in the brain, heart, eyes, and muscle tissue. Taurine can be synthesized in the body and can also be obtained from the diet, especially meat, fish, and dairy products. It is also a common ingredient in energy drinks. (source)

Taurine acts as a neurotransmitter in the brain and has a calming effect on the nervous system. It also plays a role in regulating calcium levels in certain cells, contributes to heart function, and has antioxidant properties that protect cells from damage. Taurine’s role in health, particularly heart and brain health, has been the focus of numerous medical studies. (source)

Taurine concentrations in the hippocampus, frontal cortex (anterior cingulate cortex, ACC), and occipital cortex (OCC) (red: depressed patient group, blue: healthy control group). The average taurine concentration within the hippocampus was 0.91 mM in the depressed patient group and 1.13 mM in the healthy control group. Credit: Korea Basic Science Institute (KBSI)

Pioneering research methods. MRI is widely used in brain disease research because it can accurately scan specific locations within the body and obtain a variety of quantitative information. Previous MRI studies of depression have focused on uncovering changes in metabolites mainly confined to areas of the cerebral cortex at the edges of the brain. This study is the first to reveal the relationship between metabolites in the hippocampus, located inside the brain, and depression. (source)

Detailed analysis of brain metabolites. To identify substances closely associated with depression, the research team identified seven substances that are present in the frontal, occipital, and hippocampal regions of depression: taurine, choline, creatine, glutamine, glutamic acid, myo-inositol, and N-acetylaspartate. The concentrations of two metabolites were measured and compared. young woman. (source)

When performing MRI scans, there are technical limitations to measuring metabolite concentrations within the hippocampus due to the location of the hippocampus in the brain. Taurine is also particularly difficult to obtain magnetic resonance spectroscopy (MRS) signals due to its low concentration compared to other metabolites. The research team used 7T MRI, which provides high signal sensitivity and resolution, and an sLASER pulse sequence designed to reduce chemical shift displacement errors, to detect subtle differences in taurine signals in the hippocampi of patient and control groups. succeeded in measuring. (source)

(Left) Dr. Cho Ji-hyun (Right) Dr. Song Young-gyu.Credit: Korea Basic Science Institute (KBSI)

Implications for future research. Concentrations of metabolites were also precisely measured, taking into account the precise distribution of components of white matter, gray matter, and cerebrospinal fluid (CSF), which is individual-dependent. In the future, it is expected that these measurement results will be applied to brain disease research customized to individual characteristics. (source)

KBSI research team leader Dr. Jee-Hyun Cho said, “This study will advance research on the role of taurine in the hippocampus and its relationship with depression, and will contribute to etiological research and diagnostic development of depression.” he declared. Furthermore, “Using KBSI’s cutting-edge research equipment, we plan to conduct follow-up research on changes in taurine concentration in the brain through long-term observation of patients with depression, as well as the effects of taurine intake as a treatment.” Ta. depression. (source)

collaborative efforts. The KBSI research team proposed an initial research idea on the relationship between depression and hippocampal taurine levels, performed measurements of brain metabolites using 7T MRI, and conducted an analysis of the obtained data. . The research team from KIOM and CNU participated in the recruitment of depressed patients and a healthy control group, conducted psychological tests and clinical interviews, and controlled demographic, (source)

Reference: “Association between hippocampal taurine levels and major depressive disorder in young women: A proton magnetic resonance spectroscopy study at 7 Tesla” Yong-Gyu Song, Ji-Hyun Cho, Hyun-Jung Kim, Yong-Jim, Yi-Hae Chung, Sunyoung Choi , Jeong-Hon Park, Sungho Tak, Bumwoo Park, Jin-Hun Sohn, Gyunggoo Cho, Chaejoon Cheong, September 5, 2023, biological psychiatry.[source]

DOI: 10.1016/j.biopsych.2023.08.025[source]

Source: scitechdaily.com