A man who underwent brain stimulation had previously tried 20 treatments for his depression
Damien Fair et al./cc-by 4.0
Men suffering from severe depression for over 30 years have seemingly found relief through a personalized brain “pacemaker” designed to selectively stimulate various brain regions.
“He’s felt joy for the first time in years,” states Damien Fair from the University of Minnesota.
Treatment-resistant depression is often characterized by minimal improvement after trying at least two antidepressants. While procedures like electroconvulsive therapy (ECT) may provide some benefits, they don’t always yield relief. “They’re effective for all sizes. You’ll target the same brain area,” Fair explains. Yet, as every brain is unique, he often doesn’t hit the exact target needed for individual relief.
Fair and his team have now created a tailored method for a 44-year-old man, who was first hospitalized for depression at 1 PM. He had attempted 20 different treatments, including antidepressants, therapy, ECT, and more, all without lasting success. “It’s one of the most severe depression cases I’ve seen; he has attempted suicide three times,” Fair notes.
Initially, the researchers conducted a 40-minute MRI scan to delineate the boundaries of four brain activity networks linked to depression. This particular network in the man was found to be four times more active than that of individuals without depression, potentially exacerbating his symptoms, according to Fair.
The team then surgically implanted clusters of four electrodes at these defined boundaries, entering through two small openings in the skull. Just three days later, they began sending weak electrical pulses through wires attached to the electrodes, stimulating each brain network separately.
Upon stimulating the first network—default mode, related to introspection and memory—the man cried tears of joy. “I felt so much better,” Fair recalls.
Stimulation of the Action Mode and Salience Networks also led to reduced feelings of anxiety, while the team noticed enhanced focus when targeting the parietal networks involved in decision-making.
Using the man’s feedback, the team connected the electrode wires to tiny batteries placed just beneath the skin near the collarbone, allowing him to maintain these benefits outside the hospital. This setup acts like a “brain pacemaker,” as Fair describes it, stimulating various networks for a minute each day.
For six months, the man utilized an app linked to the pacemaker to alternate between different stimulation patterns crafted by the team every few days. He also documented his depression symptoms daily. The team optimized the stimulation based on this data during the first six months post-surgery.
Even seven weeks post-surgery, the man reported no suicidal thoughts. By the nine-month mark, he was in remission as per the Hamilton Depression Rating Scale. This improvement persisted for over two and a half years, apart from a brief period when his symptoms slightly recurred after contracting Covid-19.
“This is an incredible outcome,” states Mario Juruna from King’s College London. “It serves as a crucial proof of concept for patients unable to tolerate traditional depression treatments.”
It’s plausible that the expanded salience network of the man played a role in the treatment’s success. This is often present in depression; however, it’s premature to conclude if individuals with a lower level of salience network expansion would respond similarly, Juruena states.
To confirm the safety and effectiveness of this approach, randomized controlled trials assigning various individuals with depression to either stimulation or placebo will be necessary, according to Juruena. The team aims to conduct these trials within two years after testing the method on additional individuals, according to Fair.
If you need someone to listen, reach out: Samaritans in the UK at 116123 (Samaritans.org); US 988 Suicide & Crisis Lifeline: 988 (988lifeline.org). Visit bit.ly/suicidehelplines for resources in other countries
Palestinian children wait for food prepared in a charity kitchen as food supplies run short in Rafah
Ismael Mohamad/UPI/Shutterstock
The situation in Gaza is rapidly evolving into the worst humanitarian crisis in modern memory, and international health organizations have no long-term plan to address the region’s post-war needs.
More than three-quarters of Gaza’s 2.2 million residents, half of whom are children, are internally displaced, trapped in one of the world’s most densely populated areas and without access to food, water, or health care. Since October 7, when Hamas militants in Gaza invaded Israel, killing more than 1,000 civilians, Israel has heavily bombed the enclave, disrupting the flow of humanitarian aid and destroying civilian infrastructure. As a result, more than 30,000 Palestinians, mostly women and children, were killed, and more than 72,000 were injured in Gaza, according to the United Nations.
But these numbers only mark the beginning of a public health disaster. Those who survive the war will face lifelong health effects. Thousands of Palestinians will be living with missing limbs, weakened immune systems, mental illnesses, and other chronic illnesses. Meeting their health needs will be a decades-long undertaking, and no global aid organization has adequately planned for it.
The World Health Organization, World Food Programme, UNICEF, Palestine Red Crescent Society, CARE International, Mercy Corps, and Médecins Sans Frontières all have specific projects to address health needs in the Gaza Strip, according to information shared by the organizations. Lack of long-term planning. new scientist. Save the Children and the International Committee of the Red Cross did not respond to questions about long-term plans.
unprecedented humanitarian disaster
The lack of planning for health needs in the coming decades contributes to the enormity of the current humanitarian crisis. Most of Gaza’s residents live in crowded conditions without sewage treatment or garbage removal. On average, people can consume less than 1 liter of clean water per day. As a result, infectious diseases spread.
A survey conducted in a limited number of shelters in December and January found that at least 90% of children under 5 years of age have one or more infections, and 70% have experienced diarrhea within the past 2 weeks. “And it doesn’t take into account the hundreds of thousands of people who are not in refugee shelters,” he says. Margaret Harris At WHO.
Hunger is also widespread. Almost two-thirds of households have one meal a day, and a quarter of the population faces imminent hunger and extreme malnutrition. The situation is most dire in northern Gaza, where one in six children is malnourished, according to the study. The Gaza Ministry of Health reported on March 7 that 20 people had died, including: 15 children Some died from malnutrition and dehydration. Inadequate monitoring means these numbers could be even higher.
“The problem with child malnutrition is that it causes further disease,” says Tanya Hadji-Hassan of Médecins Sans Frontières. Malnourished children are more susceptible to infections, and the lining of their intestines wears down, making it difficult to absorb nutrients. “So they become even more malnourished, their immune system weakens, and it just creates this vicious cycle that snowballs into death,” she says.
Bombing left much of the territory in danger. By December, UNICEF 1000 children On average, more than 10 children per day have lost one or both legs since the conflict began. And there are few options for receiving treatment for these injuries. As of February 21, only 18 of Gaza’s 40 hospitals are still functioning, but with reduced capacity. “They don’t have drugs. They don’t have machines. They don’t have power. They might have a few doctors running emergency rooms. So there’s not really a functioning medical system. I don’t,” he says. serena victor At Mercy Corps.
The overwhelming humanitarian crisis has thrown health institutions into chaos. “Never in modern history have we seen this level of violence, terror, fear, and deprivation perpetrated against any nation,” Harris said. “In a sense, we are exploring uncharted territory.”
Gaza’s impending public health crisis
Even if the war were to end tomorrow, survivors would face lifelong health consequences. Many will have physical disabilities. Some people suffer from severe mental illness. Some people develop chronic lung disease, heart disease, and cancer from chemical contaminants in bombs and destroyed buildings, Harris said.
The effects will be most severe on children. Sustained malnutrition early in life stunts growth and impairs brain development, leading to deficits in cognition, memory, motor function, and intelligence, Haji Hassan said. Your child’s immune system will also be weakened, making them more susceptible to illness. Studies have shown that malnutrition during pregnancy increases the risk of your baby developing obesity, high blood pressure, heart disease, and type 2 diabetes.a February report One in five pregnant women treated at Gaza clinics was malnourished, as was one in 10 children seen there, according to research by the international aid group Project Hope.
But the most widespread harm may be the impact on mental health, Harris said. “Imagine what it’s like for people who are going through this situation relentlessly every day. They feel terrible uncertainty. Where to go, what will happen next? You never know where your next bit of food is going to come from,” she says. Such traumatic experiences are associated with depression, anxiety, post-traumatic stress disorder (PTSD), and suicidal thoughts. For children, this trauma can disrupt brain and organ development and increase the risk of learning disabilities and mental health conditions. Without early intervention, these problems can persist into adulthood. “There’s going to be a huge burden of mental illness going forward, and it’s going to be very difficult to deal with,” Harris said.
Even adults who experienced adversity in childhood 12 times more risk Develop alcohol and drug use disorders and attempt suicide. They are also more likely to have physical health conditions such as heart disease and cancer. Young people who survive conflict are almost three times more likely to develop severe mental illness, including psychosis, than young people who have not experienced war.
Current postwar plans are not enough
Given these results, there is a need to establish a long-term health plan for Gaza. Such plans should address rebuilding infrastructure, developing mental and physical rehabilitation programs, and regular disease screening.
“It seems ridiculous for city officials to say what will happen now when people are dying trying to get a handful of bread for their families. It just doesn’t do the math,” Victor said. Masu. “But we need to think about it.”
But most organizations are just getting started. The few organizations that have protocols in place, such as the Palestinian Red Crescent Society and CARE International, are working for the next year or two, but not for decades. WHO is developing a plan to address health needs from April 2024 until the end of the year. “We are working on several different scenarios. A good scenario would be a ceasefire, so that we can really look at things. [long-term plans]” says Harris. Another possibility is that there is a war going on.
This uncertainty, along with the pressing question of who will govern Gaza in the aftermath of the conflict, makes preparing for the future extremely difficult. “The reason why we so desperately want not just a ceasefire, but a peaceful solution, is because until that happens, any plan or even consideration is just a castle in the air,” Harris said. says.
Israel restricts aid groups’ access to the area, making the few workers in Gaza unable to operate safely. “Half the time they can’t do anything. They can’t move around safely. Basic things like communications continue to be cut off,” Victor says. And many of them died. For example, a 29-year-old man who is a member of WHO’s limb reconstruction team in the Gaza Strip. Dima Abdullatif Mohammed AlhajiHarris said she was killed along with her six-month-old baby, two brothers, and her husband in an Israeli airstrike.
These risks and obstacles complicate long-term planning. “You can make any plan you want, but if you don’t know your needs, you won’t have a very useful plan,” he says.
Dealing with the widespread destruction in Gaza will require huge sums of money. Margaret Harris of the World Health Organization says early estimates suggest $204.2 million will be needed to fund health emergency planning in Gaza in 2024 alone. .
Meanwhile, a spokesperson for the Palestinian Red Crescent Society said the organization has a budget of $300 million for the campaign in Gaza, which is expected to run until the end of 2025. Approximately $38 million of this will be used for the health sector, including replenishing medical supplies. We are supplying supplies, deploying additional ambulances, and preventing infectious diseases.
This cannot begin to address the long-term health needs of Palestinians in Gaza. It’s difficult to estimate what will be needed now, but over the long term, “I think it’s safe to say it’s going to be in the billions of dollars,” Harris said.
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