How Dried Placenta Strips Promote Wound Healing and Minimize Scarring

Scanning electron micrograph of a human placenta's cross-section

Scanning Electron Micrograph of a Human Placenta Cross-Section

Science Photo Library

Research involving both mice and humans indicates that applying dried human placenta sheets as bandages can significantly improve skin wound healing while minimizing scarring.

The healing capabilities of placenta have been recognized since the early 1900s when it was utilized on burns to alleviate scarring. However, this practice declined due to risks associated with disease transmission.

Recent advancements in sterilizing and preserving placenta have revived interest in such treatments. Specifically, scientists are exploring the healing benefits of the amniotic membrane. This inner layer of the placenta contains an abundance of growth factors and immunomodulatory proteins that promote wound healing.

In the United States, several companies began sourcing amniotic membranes from placentas donated post-caesarean sections. This thin membrane is delicately separated from the placenta, freeze-dried, cut to standard sizes, packaged, and sterilized using radiation techniques. This approach preserves essential growth factors and ensures pathogen elimination, creating a tissue-paper-like wound dressing.

To assess the efficacy of these dressings in reducing scarring, Dr. Jeffrey Gartner and colleagues at the University of Arizona conducted experiments on anesthetized mice. They made surgical incisions and manipulated the wounds to intentionally slow healing.


Untreated wounds typically heal poorly and result in pronounced, lump-like scars. In stark contrast, the application of human amniotic bandages resulted in far superior healing, yielding scars that were thinner, flatter, and significantly less visible. Notably, the bandages caused no adverse effects in mice due to the placenta’s “immune privilege” status, which safeguards it from immune system attacks.

As a result, some surgeons in the U.S. are already utilizing amniotic bandages for clinical applications. The FDA has approved their use for treating surgical wounds and chronic, non-healing wounds due to conditions like diabetes.

A recent study, published in June 2025, evaluated the performance of these bandages in real-world clinical settings. Researcher Ryan Corey and his team at Beth Israel Deaconess Medical Center in Boston analyzed a large, national database of anonymous patient health records. They identified 593 patients who received amniotic bandages for chronic wounds and burns and compared them to a control group of 593 similar patients treated with other methods.

The findings revealed that wounds treated with amniotic bandages had a lower infection rate and were less likely to develop hypertrophic scars, which are thick, raised scars. Although these results bolster the use of amniotic bandages, Cauley et al. emphasize that “additional prospective randomized studies with extended follow-up are warranted to validate these findings.”

In parallel, research teams are investigating the potential applicability of placental tissue in healing other organs beyond the skin. In 2023, Dr. Hina Chaudhry and her colleagues at the Icahn School of Medicine at Mount Sinai in New York discovered that injecting placental cells can repair heart damage in mice, hinting at future therapies for heart attack-related damage.

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Source: www.newscientist.com

UK Council Employs AI Tools to Minimize Women’s Health Concerns, Research Shows

Research indicates that more than half of the Council of England’s use of artificial intelligence tools minimizes women’s physical and mental health issues, raising concerns about potential gender bias in care decisions. The study revealed that when generating and summarizing identical case notes using Google’s AI tool “Gemma,” terms like “invalid,” “impossible,” and “complex” appeared significantly more often in descriptions of males than females.

Conducted by the London School of Economics and Political Science (LSE), the study found that comparable care needs in women were more likely to be overlooked or inadequately explained. Dr. Samurikman, the report’s lead author and a researcher at LSE’s Care Policy and Assessment Centre, emphasized that AI could result in “unequal care provision for women.” He noted, “These models are widely used, yet our findings reveal significant disparities regarding bias across different models. Specifically, Google’s models understate women’s physical and mental health needs compared to those for men.”

Furthermore, he pointed out that the care received is often determined by perceived needs, which could lead to women receiving inadequate care if a biased model is in use—although it remains unclear which model is currently being applied.

As AI tools grow in popularity among local authorities, the LSE study analyzed real case notes from 617 adult social care users. These notes were anonymized by gender and input multiple times into various major language models (LLM). Researchers examined a summary of 29,616 pairs to assess how male and female cases were treated differently by the AI model.

One example highlighted that the Gemma model summarized case notes as follows: “Mr. Smith is an 84-year-old man living alone with a complicated medical history, a care package, and poor mobility.” Conversely, when the gender was swapped, the summary read: “Mrs. Smith is an 84-year-old resident. Despite her limitations, she is independent and can maintain personal care.” In another instance, the summary stated that Mrs. Smith “has no access to the community,” while Mr. Smith “has managed to manage her daily activities.”

Among the AI models assessed, Google’s Gemma exhibited a more significant gender-based disparity compared to other models. The study noted that Meta’s Llama 3 model did not differentiate its language based on gender.

Dr. Rickman commented that although the tool “is already in use in the public sector, it should not compromise fairness.” He added, “My research sheds light on the issues posed by a single model, but with many models continuously being deployed, it is imperative that all AI systems are transparent, rigorously tested for bias, and subject to stringent legal oversight.”

The paper concludes that to prioritize “algorithm equity,” regulators should mandate measures of bias in LLMs used in long-term care. Concerns regarding racial and gender bias in AI tools have persisted for an extended period, as machine learning technology tends to absorb biases present in human languages. Our research analyzed 133 AI systems across various industries, revealing that approximately 44% exhibited gender bias, while 25% showed both gender and racial biases.

According to Google, the team is reviewing the report’s findings. The researcher assessed the initial generation of the GEMMA model, which is currently in its third generation and is expected to show improved performance; however, it should not be utilized for medical purposes.

Source: www.theguardian.com

Energy Drinks: Simple Additions to Minimize Tooth Damage

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Energy drinks can enhance your mood, but excessive intake may harm your dental health.

Shutterstock/Francesco de Marc

Calcium-fortified energy drinks may mitigate tooth damage, though the impact on flavor remains uncertain.

Research reveals that dental enamel starts to erode when exposed to liquids with a pH below 5.5.

Investigating solutions, Eric Jacom from the University of Rio Grande and Grande in Brazil, along with his team, experimented with adding calcium and other minerals to standard Red Bull to assess the pH impact.

Notable combinations included calcium, phosphorus, and potassium, raising pH from 3.96 (for standard Red Bull) to 5.27, while dicoum malonate and calcium citrate both increased acidity.

The researchers exposed enamel samples from donated human teeth to these enhanced energy drinks for two minutes, evaluating changes in texture, hardness, and other indicators of enamel erosion.

All calcium-enriched variants showed less effect on roughness compared to the unmodified Red Bull, despite having a lower pH. Experts believe this might be due to calcium’s regenerative properties, which aid in mineral deposition on enamel to repair natural wear.

The formulation containing 2.15 grams of calcium-phosphorus-potassium mix and 2.5 grams of dicoum malate sustained enamel hardness. However, the former offers the most protective benefits, demonstrating a dual action of lowering calcium depletion while reducing acidity.

Future investigations should focus on identifying the optimal calcium formulation and the minimum concentration necessary to minimize enamel erosion, the researchers noted in their paper. Additionally, it is crucial to determine if calcium enhancement influences drink preferences and consumption patterns.

Before any shifts in formulation, David Bartlett from King’s College London advises that it’s premature to adjust energy drink compositions. “We recommend avoiding acidic foods or drinks between meals.” Consuming acidic foods and beverages in moderation is seen as less harmful since increased saliva helps neutralize some acid.

A representative from the UK Soft Drinks Association stated: “It’s important to reiterate that all soft beverages can be safely enjoyed within a balanced diet and healthy lifestyle.

Red Bull has not responded to requests for comment.

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Source: www.newscientist.com