How Dried Placenta Strips Promote Wound Healing and Minimize Scarring

Scanning electron micrograph of a human placenta's cross-section

Scanning Electron Micrograph of a Human Placenta Cross-Section

Science Photo Library

Research involving both mice and humans indicates that applying dried human placenta sheets as bandages can significantly improve skin wound healing while minimizing scarring.

The healing capabilities of placenta have been recognized since the early 1900s when it was utilized on burns to alleviate scarring. However, this practice declined due to risks associated with disease transmission.

Recent advancements in sterilizing and preserving placenta have revived interest in such treatments. Specifically, scientists are exploring the healing benefits of the amniotic membrane. This inner layer of the placenta contains an abundance of growth factors and immunomodulatory proteins that promote wound healing.

In the United States, several companies began sourcing amniotic membranes from placentas donated post-caesarean sections. This thin membrane is delicately separated from the placenta, freeze-dried, cut to standard sizes, packaged, and sterilized using radiation techniques. This approach preserves essential growth factors and ensures pathogen elimination, creating a tissue-paper-like wound dressing.

To assess the efficacy of these dressings in reducing scarring, Dr. Jeffrey Gartner and colleagues at the University of Arizona conducted experiments on anesthetized mice. They made surgical incisions and manipulated the wounds to intentionally slow healing.


Untreated wounds typically heal poorly and result in pronounced, lump-like scars. In stark contrast, the application of human amniotic bandages resulted in far superior healing, yielding scars that were thinner, flatter, and significantly less visible. Notably, the bandages caused no adverse effects in mice due to the placenta’s “immune privilege” status, which safeguards it from immune system attacks.

As a result, some surgeons in the U.S. are already utilizing amniotic bandages for clinical applications. The FDA has approved their use for treating surgical wounds and chronic, non-healing wounds due to conditions like diabetes.

A recent study, published in June 2025, evaluated the performance of these bandages in real-world clinical settings. Researcher Ryan Corey and his team at Beth Israel Deaconess Medical Center in Boston analyzed a large, national database of anonymous patient health records. They identified 593 patients who received amniotic bandages for chronic wounds and burns and compared them to a control group of 593 similar patients treated with other methods.

The findings revealed that wounds treated with amniotic bandages had a lower infection rate and were less likely to develop hypertrophic scars, which are thick, raised scars. Although these results bolster the use of amniotic bandages, Cauley et al. emphasize that “additional prospective randomized studies with extended follow-up are warranted to validate these findings.”

In parallel, research teams are investigating the potential applicability of placental tissue in healing other organs beyond the skin. In 2023, Dr. Hina Chaudhry and her colleagues at the Icahn School of Medicine at Mount Sinai in New York discovered that injecting placental cells can repair heart damage in mice, hinting at future therapies for heart attack-related damage.

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Source: www.newscientist.com

Sexual Activity Might Alleviate Stress and Enhance Wound Healing

Regular intimacy may offer health advantages

Maria Kornieva/Getty Images

Engagement in sexual activity or even simple intimate contact might accelerate wound healing, especially when paired with oxytocin nasal spray.

Oxytocin, often dubbed the “love hormone” or “cuddle chemical,” is known for stimulating uterine contractions during childbirth and aiding breastfeeding. It’s also linked to social connections and intimacy. Previous studies suggest it can facilitate healing of conditions like oral ulcers, likely due to its anti-inflammatory properties.

Furthermore, a contentious relationship between partners may contribute to slower healing of blisters. Researchers, including Beate Ditzen from the University of Zurich, speculated whether a lack of oxytocin during these strained interactions could be a mediating factor.

To explore this, the team conducted a study involving 80 healthy heterosexual couples, averaging 27 years of age, all of whom had four small wounds created on their forearms through a suction device.

The couples were split into four groups, each assigned different interventions for the following week. One group received oxytocin nasal spray twice daily while engaging in a 10-minute Partner Appreciation Task (PAT) — a structured activity focusing on expressing gratitude and compliments up to three times a week.

The second group also used oxytocin but did not participate in PAT. The third group carried out PAT with a placebo spray, while the fourth group used a placebo without any PAT intervention.

Neither using oxytocin alone nor engaging in PAT with a placebo led to faster wound healing compared to the control group without spray and PAT. However, the combination of oxytocin and PAT showed some effectiveness in reducing scars’ size and depth, especially among couples who reported increased physical affection or sexual activity during the study week. This was also linked to lower cortisol levels, a stress hormone known to hinder immune function, observed in saliva samples.

“We observe enhanced wound healing in groups that incorporate PAT; however, the effects are significantly more pronounced when oxytocin is combined with spontaneous contact or intimate behaviors,”

Darryl O’Connor from the University of Leeds noted, “Our findings are intriguing as they imply that pairing oxytocin administration with positive interpersonal interactions might bolster physical recovery, opening promising avenues for future psychosocial interventions in healthcare settings.”

According to Anna Whitaker, researchers at the University of Stirling in the UK suggest that increased doses of oxytocin may yield similar benefits, particularly for older adults with generally weakened immune systems.

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Source: www.newscientist.com

Chimpanzees Utilize Healing Plants for Wound Care

New research has revealed that wild chimpanzees are capable of self-medicating their wounds with plants, assisting injured companions, and freeing others from traps set by human hunters.

This behavior, documented in a study published in the journal Frontiers of Evolution and Ecology on Wednesday, offers new insights into the evolutionary roots of human medicine.

Over approximately eight months, the study combined video footage and photographs with historical data, revealing that chimpanzees engage in actions like biting plants, applying leaves to wounds as makeshift bandages, and grooming wounds of fellow animals. Observers noted a chimpanzee pressing a leaf against its wound for treatment.

The findings contribute to ongoing discussions about whether altruistic behaviors are exclusive to humans, as they show that even chimpanzees without familial ties can exhibit care toward one another.

Wild chimpanzees in Uganda grooming.
Elodie Freymann

“Humans often pride themselves on being unique in their capacity for empathy and altruism,” says Elodie Freyman, a postdoctoral researcher at Oxford University and the study’s lead author. “These animals demonstrate that they can identify others in need and respond appropriately.”

Chimpanzees and bonobos, the closest genetic relatives to humans, bolster the argument that healthcare concepts may have existed millions of years prior to the emergence of Homo sapiens.

“Our shared ancestors likely exhibited these caring behaviors,” Freyman stated.

An increasing number of studies indicates that various animal species can self-medicate with differing levels of sophistication. For instance, elephants have been observed to consume specific leaves for medicinal purposes, hinting that animals might be addressing health issues like digestion.

As research on animal medicinal behaviors expands, experts believe it provides crucial insights into our own evolutionary past.

“Evidence of healthcare behaviors exists among our ancestors, dating back to pre-Neanderthals, but the evolutionary pathways of such explorative behaviors remain unclear,” remarked Alessandra Mascaro, a primate researcher and doctoral candidate at the University of Osnabrueck in Germany. “We are only beginning to uncover these complexities.”

In 2022, Mascaro published findings illustrating that Gabonian chimpanzees applied insects to their own wounds and anticipates that further observations will clarify how these behaviors evolved.

Studying chimpanzee self-medication poses challenges due to the rarity of such behaviors.

Freyman dedicated two months to researching chimpanzees in Budongo Forest, Uganda, where observing these animals can be both physically taxing and demanding.

Wild chimpanzees in Uganda grooming.
Elodie Freymann

“Some days involve sitting at the base of a tree for hours, while others might have you stuck in a muddy hole while trying to observe them. The day’s tasks depend heavily on the group’s activities.

During her fieldwork, Freyman noted numerous instances of care behaviors among chimpanzees. She also discovered historical observational records from previous studies that revealed behaviors not documented until now, indicating a pattern of medicinal practices dating back to the 1990s.

“Collating these observations paints a remarkable picture of chimpanzee care,” she remarked.

From her findings and historical records, Freyman documented 41 instances of chimpanzee wound care, including four cases involving unrelated individuals.

“These results suggest that prosocial behaviors among nonkin may be more widespread than previously recognized,” noted Isabel Laumer, a cognitive biologist at the Max Planck Institute for Animal Behavior in Germany, who was not part of this study. “Further research is essential.”

Mascaro, who has studied chimpanzee healthcare behaviors in Gabon, acknowledged that the new findings from Uganda show similar medicinal behaviors across different populations of chimpanzees.

“Prior to this, we had limited knowledge about chimpanzees in that part of Africa,” Mascaro stated.

The phenomenon of self-medication has also been observed in other primates. Last year, Laumer documented that Indonesian orangutans apply leaves to facial wounds as a remedy for injuries sustained during conflicts. The plants they utilize often possess pain-relieving properties recognized by humans.

This body of research broadly indicates that primates are capable of identifying and utilizing plants with medicinal qualities.

“Chimpanzees consider forests not only as a food source but also as a repository for medicinal resources,” Freyman emphasized, underscoring the importance of preserving forest ecosystems.

She suggested that humans may have learned about medicinal plants from these primates, and that pharmaceutical companies could benefit from studying animal behavior to discover valuable medical compounds in the future.

“If you wish to refine the knowledge of these remarkable medicinal resources, observing and learning from animals is an effective, ethical, and responsible approach,” Freyman concluded.

Source: www.nbcnews.com