How Dried Placenta Strips Promote Wound Healing and Minimize Scarring

Scanning electron micrograph of a human placenta's cross-section

Scanning Electron Micrograph of a Human Placenta Cross-Section

Science Photo Library

Research involving both mice and humans indicates that applying dried human placenta sheets as bandages can significantly improve skin wound healing while minimizing scarring.

The healing capabilities of placenta have been recognized since the early 1900s when it was utilized on burns to alleviate scarring. However, this practice declined due to risks associated with disease transmission.

Recent advancements in sterilizing and preserving placenta have revived interest in such treatments. Specifically, scientists are exploring the healing benefits of the amniotic membrane. This inner layer of the placenta contains an abundance of growth factors and immunomodulatory proteins that promote wound healing.

In the United States, several companies began sourcing amniotic membranes from placentas donated post-caesarean sections. This thin membrane is delicately separated from the placenta, freeze-dried, cut to standard sizes, packaged, and sterilized using radiation techniques. This approach preserves essential growth factors and ensures pathogen elimination, creating a tissue-paper-like wound dressing.

To assess the efficacy of these dressings in reducing scarring, Dr. Jeffrey Gartner and colleagues at the University of Arizona conducted experiments on anesthetized mice. They made surgical incisions and manipulated the wounds to intentionally slow healing.


Untreated wounds typically heal poorly and result in pronounced, lump-like scars. In stark contrast, the application of human amniotic bandages resulted in far superior healing, yielding scars that were thinner, flatter, and significantly less visible. Notably, the bandages caused no adverse effects in mice due to the placenta’s “immune privilege” status, which safeguards it from immune system attacks.

As a result, some surgeons in the U.S. are already utilizing amniotic bandages for clinical applications. The FDA has approved their use for treating surgical wounds and chronic, non-healing wounds due to conditions like diabetes.

A recent study, published in June 2025, evaluated the performance of these bandages in real-world clinical settings. Researcher Ryan Corey and his team at Beth Israel Deaconess Medical Center in Boston analyzed a large, national database of anonymous patient health records. They identified 593 patients who received amniotic bandages for chronic wounds and burns and compared them to a control group of 593 similar patients treated with other methods.

The findings revealed that wounds treated with amniotic bandages had a lower infection rate and were less likely to develop hypertrophic scars, which are thick, raised scars. Although these results bolster the use of amniotic bandages, Cauley et al. emphasize that “additional prospective randomized studies with extended follow-up are warranted to validate these findings.”

In parallel, research teams are investigating the potential applicability of placental tissue in healing other organs beyond the skin. In 2023, Dr. Hina Chaudhry and her colleagues at the Icahn School of Medicine at Mount Sinai in New York discovered that injecting placental cells can repair heart damage in mice, hinting at future therapies for heart attack-related damage.

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Source: www.newscientist.com

People with Red Hair May Experience Slower Healing for Cuts and Scrapes.

Our hair color seems to influence wound healing in unexpected ways

Stock Enjoy/Shutterstock

Red-haired individuals might experience slower wound healing compared to those with blonde, brunette, or dark hair. Research conducted on mice indicated that genetic differences related to hair color may affect the speed at which wounds heal, insights that could lead to improved treatment strategies for various hair colors.

The genes responsible for our hair color play a significant role. The gene MC1R is critical as it produces a protein determining the balance of black-brown and red-yellow pigments within hair follicles.

Individuals with brown or black hair typically have an MC1R variant encoding the active version of this protein. In contrast, nearly all redheads possess a less active or entirely inactive variant due to MC1R mutations. The genetics of hair pigmentation is complex for blondes, too, as they can display either active or inactive protein forms.

This protein is also present in the skin and has an anti-inflammatory effect. This led Jenna Cash from the University of Edinburgh to explore its influence on wound healing. The healing process requires an initial inflammatory response to clear out pathogens and dead cells from the injury site; however, if this response is too intense or prolonged, it can hinder proper healing.

To examine this, she and her team surgically created 4-millimeter wounds on the backs of black and red-haired mice, the latter having completely inactive MC1R protein.

After a week, red-haired mice exhibited an average scar contraction of 73%, while dark-haired mice showed a 93% contraction.

With these results in mind, the researchers hypothesized that an experimental topical agent, which enhances the activity of the active protein form (without impacting the inactive form), could aid in healing chronic wounds. This is particularly relevant for diabetics, in whom persistent high blood sugar can lead to excessive inflammation and delayed healing.

To test this hypothesis, the researchers inflicted wounds on black-haired mice and treated them with medication and bandages, while other black-haired mice with similar wounds received saline and bandages instead.

After one week, wounds of the treated mice had closed by an average of 63%, significantly larger than those of control group mice. “Patients would likely be pleased if their scars were visibly smaller, especially in a short timeframe,” noted Cash. Further analyses revealed the drug’s mechanism: it reduces the number of inflammatory immune cells.

This approach offers potential for treating humans, including redheads, as healing processes show remarkable similarities between mice and humans, most of whom have the MC1R protein functioning to some extent, Cash notes. However, patients with completely inactive forms may not see benefits.

Drugs targeting this protein are currently used for conditions like erythropoietic protoporphyria, making the researchers optimistic about the safety profile of this approach, according to Cash. Nonetheless, further studies are necessary to confirm this, as highlighted by Cas Bogey from Case Western Reserve University. Plans for human trials will commence shortly.

Future studies should also investigate the drug’s safety and efficacy on infected wounds, as Bogey pointed out. “The medication might interfere with the infection response or cause unintended side effects,” she cautioned.

This news may not be received well by some redheads. Prior studies indicate that red-haired individuals might also experience heightened sensitivity to pain. However, Cash reassures, “There’s no cause for alarm. We currently lack human data. Even if individuals with red hair heal somewhat more slowly, the difference may be negligible and hardly noticeable.”

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Source: www.newscientist.com

Sexual Activity Might Alleviate Stress and Enhance Wound Healing

Regular intimacy may offer health advantages

Maria Kornieva/Getty Images

Engagement in sexual activity or even simple intimate contact might accelerate wound healing, especially when paired with oxytocin nasal spray.

Oxytocin, often dubbed the “love hormone” or “cuddle chemical,” is known for stimulating uterine contractions during childbirth and aiding breastfeeding. It’s also linked to social connections and intimacy. Previous studies suggest it can facilitate healing of conditions like oral ulcers, likely due to its anti-inflammatory properties.

Furthermore, a contentious relationship between partners may contribute to slower healing of blisters. Researchers, including Beate Ditzen from the University of Zurich, speculated whether a lack of oxytocin during these strained interactions could be a mediating factor.

To explore this, the team conducted a study involving 80 healthy heterosexual couples, averaging 27 years of age, all of whom had four small wounds created on their forearms through a suction device.

The couples were split into four groups, each assigned different interventions for the following week. One group received oxytocin nasal spray twice daily while engaging in a 10-minute Partner Appreciation Task (PAT) — a structured activity focusing on expressing gratitude and compliments up to three times a week.

The second group also used oxytocin but did not participate in PAT. The third group carried out PAT with a placebo spray, while the fourth group used a placebo without any PAT intervention.

Neither using oxytocin alone nor engaging in PAT with a placebo led to faster wound healing compared to the control group without spray and PAT. However, the combination of oxytocin and PAT showed some effectiveness in reducing scars’ size and depth, especially among couples who reported increased physical affection or sexual activity during the study week. This was also linked to lower cortisol levels, a stress hormone known to hinder immune function, observed in saliva samples.

“We observe enhanced wound healing in groups that incorporate PAT; however, the effects are significantly more pronounced when oxytocin is combined with spontaneous contact or intimate behaviors,”

Darryl O’Connor from the University of Leeds noted, “Our findings are intriguing as they imply that pairing oxytocin administration with positive interpersonal interactions might bolster physical recovery, opening promising avenues for future psychosocial interventions in healthcare settings.”

According to Anna Whitaker, researchers at the University of Stirling in the UK suggest that increased doses of oxytocin may yield similar benefits, particularly for older adults with generally weakened immune systems.

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Source: www.newscientist.com

A New Perspective on Oral Healing: Paving the Way to a “Woundless World”

Fibroblast cells that play a role in forming connective tissue and are also involved in scarring

Dr. Torsten Wittmann/Science Photography Library

Recent discoveries about how mouth injuries heal without bruising could lead to treatment methods that prevent permanent scars and improve skin appearance.

“Millions of individuals experience injuries, surgeries, burns, and various other traumas,” states Ophir Klein from Cedars-Sinai Medical Center in Los Angeles, California. “This represents a significant issue not only in cosmetic terms but also functional terms,” he adds. For instance, he mentions that a major wound can restrict leg movement due to skin tightening.

To explore this, Klein and his team took advantage of the fact that mouth wounds heal without scarring. “Injuries inside the mouth heal more quickly and with fewer scars compared to skin injuries,” he explains.

Upon investigation, the researchers created 2.5mm wide wounds both in the mouth and on the face of mice. They collected tissue samples as these wounds healed over the course of a week.

The team analyzed cells known as fibroblasts that are associated with scarring and discovered that fibroblasts in the mouth exhibited higher activity levels for genes encoding proteins such as Gas6 and Axl than those in the skin. These proteins are known to promote cell growth, migration, and survival.

The Gas6-Axl pathway seemed to inhibit the levels of a protein called FAK, which is involved in depositing proteins on wounds, leading to scar formation. “We were aware of this pathway’s existence, but its role in non-scarring wound healing was unknown,” Klein notes.

The next step for the researchers was to assess whether enhancing the Gas6-Axl pathway could minimize skin scarring. They administered a solution containing Gas6 to freshly created facial scars on mice. After two weeks, these treated wounds exhibited reduced FAK levels and fewer scars compared to those in untreated mice. “They have successfully shown that stimulating this pathway can diminish scarring,” says Jason Wong at the University of Manchester, UK.

“This is certainly a significant step towards what could be a scar-free future,” states Ines Sequeira from Queen Mary University in London. However, he cautions that further research is needed with larger animals like pigs, which have skin more similar to humans, before moving towards human trials.

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Source: www.newscientist.com

Chimpanzees Utilize Healing Plants for Wound Care

New research has revealed that wild chimpanzees are capable of self-medicating their wounds with plants, assisting injured companions, and freeing others from traps set by human hunters.

This behavior, documented in a study published in the journal Frontiers of Evolution and Ecology on Wednesday, offers new insights into the evolutionary roots of human medicine.

Over approximately eight months, the study combined video footage and photographs with historical data, revealing that chimpanzees engage in actions like biting plants, applying leaves to wounds as makeshift bandages, and grooming wounds of fellow animals. Observers noted a chimpanzee pressing a leaf against its wound for treatment.

The findings contribute to ongoing discussions about whether altruistic behaviors are exclusive to humans, as they show that even chimpanzees without familial ties can exhibit care toward one another.

Wild chimpanzees in Uganda grooming.
Elodie Freymann

“Humans often pride themselves on being unique in their capacity for empathy and altruism,” says Elodie Freyman, a postdoctoral researcher at Oxford University and the study’s lead author. “These animals demonstrate that they can identify others in need and respond appropriately.”

Chimpanzees and bonobos, the closest genetic relatives to humans, bolster the argument that healthcare concepts may have existed millions of years prior to the emergence of Homo sapiens.

“Our shared ancestors likely exhibited these caring behaviors,” Freyman stated.

An increasing number of studies indicates that various animal species can self-medicate with differing levels of sophistication. For instance, elephants have been observed to consume specific leaves for medicinal purposes, hinting that animals might be addressing health issues like digestion.

As research on animal medicinal behaviors expands, experts believe it provides crucial insights into our own evolutionary past.

“Evidence of healthcare behaviors exists among our ancestors, dating back to pre-Neanderthals, but the evolutionary pathways of such explorative behaviors remain unclear,” remarked Alessandra Mascaro, a primate researcher and doctoral candidate at the University of Osnabrueck in Germany. “We are only beginning to uncover these complexities.”

In 2022, Mascaro published findings illustrating that Gabonian chimpanzees applied insects to their own wounds and anticipates that further observations will clarify how these behaviors evolved.

Studying chimpanzee self-medication poses challenges due to the rarity of such behaviors.

Freyman dedicated two months to researching chimpanzees in Budongo Forest, Uganda, where observing these animals can be both physically taxing and demanding.

Wild chimpanzees in Uganda grooming.
Elodie Freymann

“Some days involve sitting at the base of a tree for hours, while others might have you stuck in a muddy hole while trying to observe them. The day’s tasks depend heavily on the group’s activities.

During her fieldwork, Freyman noted numerous instances of care behaviors among chimpanzees. She also discovered historical observational records from previous studies that revealed behaviors not documented until now, indicating a pattern of medicinal practices dating back to the 1990s.

“Collating these observations paints a remarkable picture of chimpanzee care,” she remarked.

From her findings and historical records, Freyman documented 41 instances of chimpanzee wound care, including four cases involving unrelated individuals.

“These results suggest that prosocial behaviors among nonkin may be more widespread than previously recognized,” noted Isabel Laumer, a cognitive biologist at the Max Planck Institute for Animal Behavior in Germany, who was not part of this study. “Further research is essential.”

Mascaro, who has studied chimpanzee healthcare behaviors in Gabon, acknowledged that the new findings from Uganda show similar medicinal behaviors across different populations of chimpanzees.

“Prior to this, we had limited knowledge about chimpanzees in that part of Africa,” Mascaro stated.

The phenomenon of self-medication has also been observed in other primates. Last year, Laumer documented that Indonesian orangutans apply leaves to facial wounds as a remedy for injuries sustained during conflicts. The plants they utilize often possess pain-relieving properties recognized by humans.

This body of research broadly indicates that primates are capable of identifying and utilizing plants with medicinal qualities.

“Chimpanzees consider forests not only as a food source but also as a repository for medicinal resources,” Freyman emphasized, underscoring the importance of preserving forest ecosystems.

She suggested that humans may have learned about medicinal plants from these primates, and that pharmaceutical companies could benefit from studying animal behavior to discover valuable medical compounds in the future.

“If you wish to refine the knowledge of these remarkable medicinal resources, observing and learning from animals is an effective, ethical, and responsible approach,” Freyman concluded.

Source: www.nbcnews.com

Experience the Healing Benefits of Forest Bathing for Better Health – Here’s How

Forest bathing is an ancient Japanese therapeutic technique dating back to the 1980s. It involves spending restorative time in forests and natural environments to connect with nature and achieve sensory relaxation. Despite sounding like hippie nonsense, there is scientific evidence emerging that supports the benefits of forest bathing.

This practice does not involve any nudity or water activities; instead, it encourages mindfulness, disconnecting from technology, light exercise, and escaping the sensory overload of the modern world. Research has shown that spending time in nature can have a positive impact on mental and physical health, reducing blood pressure, cortisol levels, and heart rate.

Studies on green space exposure have demonstrated significant improvements in various health markers, such as lower rates of diabetes, cardiovascular disease, and mortality. Forest bathing is taken seriously in Japan and South Korea, where doctors prescribe it as a therapeutic intervention for stress and hypertension.

A UK study on forest bathing led by Dr. Kirsten McEwan has shown promising results, including a 12% improvement in heart rate variability and enhanced mood. The mechanism behind these health benefits is believed to involve the stimulation of the parasympathetic nervous system and the release of chemicals by trees that boost the immune system.

Nature’s impact on long-term health outcomes is still being studied, but initial findings suggest that spending time in nature can have significant health benefits. Perhaps Western medicine is beginning to recognize and embrace the benefits of traditional practices like forest bathing, aligning with generations of knowledge that being outside in nature is good for overall well-being.

About our experts

Dr. Kirsten McEwan, Associate Professor of Health and Wellbeing at the University of Derby, is leading research on forest bathing through the Forest Therapy Hub.

Source: www.sciencefocus.com