Families of individuals who passed away following pig organ transplants are at peace with their decision.

David Bennett Jr. knelt at his bedside, phone in hand, anxiously waiting for the call he’d never received before: The hospital was supposed to update him on whether his father, who had received a new heart transplanted from a pig, was still alive.

It was the first time a living human had received a pig organ transplant.

“I don’t know what the news is, but my dad opened his eyes, he was awake and he was OK. It was unbelievable,” Bennett Jr. said.

Bennett’s father, David Bennett Sr., had severe congestive heart failure and was not a candidate for a transplant. He knew he would likely die soon. There was nothing else he could do but take a chance on a novel, cutting-edge procedure. Bennett Sr. and his son agreed it was worth the risk.

The achievement made headlines around the world following the transplant in January 2022. Initially, the results looked promising, with some family members beginning to entertain the idea that Bennett Sr. might eventually be released from the hospital.

“There were definitely future-oriented conversations about the home environment, who was going to care for him and what that was going to look like,” Bennett Jr. said. “Everyone was very optimistic and hopeful.”

David Bennett Jr. and his family.
Jesse Barber, NBC News

But two months later, Bennett Sr.’s body rejected the heart and he died at age 57. paperDoctors at the University of Maryland Medical Center said his body likely produced too many antibodies to fight the new organ. The drugs he was given may have also increased the chance of rejection, and a virus in the pig’s heart further complicates things.

Three other patients have followed in Bennett Sr.’s footsteps and received pig organs, most recently a pig kidney transplant in April. Together, they are pioneers in the burgeoning field of xenotransplantation. For them, the journey has been a roller coaster of emotions, from anxiety to blind hope and ultimately praise for their loved one’s decision, three family members told NBC News.

“Obviously, I wish my dad was still here, but I know his sacrifice was not in vain,” Bennett Jr. said.

None of the patients survived more than three months. To the public, it may have seemed a failure. But to their families, the transplants had accomplished a goal: to buy their loved ones more time and to advance research that may one day save their lives.

“Larry thought: He’s going to die. It’s inevitable, it’s coming,” says Anne Fawcett, whose husband of nearly 38 years, Laurence Fawcett, is the second person to receive a pig heart transplant. “So to gather as much data as we can, to do as much research as we can, why not use Larry’s body as a test subject, to give people in the future who need a transplant another option?”

The potential of xenotransplantation lies in the shortage of available human organs. 17 people die every day in the United States while waiting for an organ transplantBecause pig organs are more readily available, doctors expect such surgeries to become as common as hip replacements in the future, according to the Health Resources and Services Administration.

Source: www.nbcnews.com

Our Solar System passed through a frigid interstellar cloud approximately 2 million years ago, new research reveals.

A cold, dense cloud in the Milky Way’s interstellar medium is about four to five orders of magnitude denser than its diffuse counterparts, and a team of astronomers from Boston University, Harvard University, and Johns Hopkins University has found evidence that two to three million years ago, our solar system encountered one of these dense clouds, which may have been so dense that it disrupted the solar wind.



Offers othersThe interstellar material through which the Sun has traveled over the past few million years indicates the presence of cold, dense clouds that could have had dramatic effects on the heliosphere. Image credit: NASA/JPL-Caltech.

Most stars generate winds that move through the surrounding interstellar medium.

This motion creates a cocoon that protects the planet from interstellar material. The Sun’s cocoon is the heliosphere.

It’s made up of a constant stream of charged particles called the solar wind, which extends far beyond Pluto, enveloping the planet in what astronomers call a “local bubble.”

It protects us from radiation and galactic rays that can alter DNA, and scientists think it’s part of the reason why life on Earth evolved.

A cold interstellar cloud compressed the heliosphere, temporarily placing Earth and other planets in the solar system outside of its influence, according to a new study.

“Our paper is the first to quantitatively show that there was an encounter between the Sun and something outside our solar system that affected Earth’s climate,” said Professor Merab Auffar of Boston University.

“Stars move, and this paper shows that not only do they move, but they undergo dramatic changes.”

To study this phenomenon, Professor Orpher and his colleagues essentially went back in time and used advanced computer models to visualize where the Sun was located two million years ago, along with the heliosphere and the rest of the solar system.

They also mapped the path of a “localized cold cloud ribbon” system, a series of large, dense and very cold clouds made mainly of hydrogen atoms.

Their simulations showed that one of the clouds near the edge of the ribbon, a “local cold cloud,” may have collided with the heliosphere.

If this had happened, Earth would have been fully exposed to interstellar matter, where gases and dust would have mixed with atomic elements left over from the exploded star, such as iron and plutonium.

Normally, the heliosphere filters out most of these radioactive particles, but without protection they could easily reach Earth.

This is consistent with geological evidence showing increased levels of the isotopes iron-60 and plutonium-244 in the oceans, the moon, Antarctic snow and ice cores from the same period, according to the paper.

This timing also coincides with temperature records indicating a cold period.

“It is rare for our cosmic neighbors outside our solar system to have an impact on life on Earth,” said Harvard University professor Avi Loeb.

“It’s exciting to discover that our passage through dense clouds millions of years ago may have exposed the Earth to much greater amounts of cosmic rays and atomic hydrogen.”

“Our findings open a new window into the evolution of life on Earth and its relationship with our cosmic neighbours.”

“External pressure from localized lynxes of cold clouds could have continuously blocked the heliosphere for hundreds to millions of years, depending on the size of the cloud.”

“But as soon as Earth left the cold cloud, the heliosphere engulfed all the planets, including Earth.”

“It’s impossible to know exactly what effect the cold clouds had on the Earth, such as whether they caused ice ages.”

“But there are other cool clouds in the interstellar medium that the Sun likely encountered in its first few billion years.”

“And we’ll probably encounter many more over the next million years or so.”

The authors are currently working to determine where the Sun was 7 million years ago, and beyond.

Pinpointing the position of the Sun and cold cloud systems millions of years ago is made possible by data collected by ESA’s Gaia mission, which has produced the largest 3D map of the galaxy ever, showing in unprecedented detail how fast stars move.

“This cloud is certainly from our past, and if we passed through something this massive, we would have been exposed to interstellar material,” Prof Auffar said.

“This is just the beginning. We hope this paper opens the door to further exploration of how the solar system was influenced by outside forces in the ancient past, and how these forces may have shaped life on Earth.”

of paper Published in today’s journal Natural Astronomy.

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M. Offer othersIt is possible that Earth was directly exposed to cold, dense interstellar material 2 to 3 million years ago. Nat AstronPublished online June 10, 2024; doi: 10.1038/s41550-024-02279-8

Source: www.sci.news