Tag Archives: Pig

Transplanting Pig Livers into Living Humans Achieves Near-Normal Functionality

Posted on by
Reply

Surgeons carry out a pig liver transplant at the First Affiliated Hospital of Anhui Medical University in China in May 2024.

Lu Xianfu

Transplants of organs from non-human animals to human recipients could transform medicine and potentially save countless lives each year as many die awaiting transplants. Past experiments have seen pig hearts and kidneys transplanted into humans, but this marks the first instance of an animal liver being transplanted into a living person.

“This is truly groundbreaking,” remarks Heiner Wedemeyer from Hannover Medical School in Germany, who was not involved in the procedure. “The patient was critically ill, but thanks to the transplant, he survived for six months.”

The complexities of the liver have prevented previous surgeries of this kind. Earlier studies were conducted on brain-dead individuals, but indications of success were observed. “The heart acts merely as a muscle for pumping blood,” Wedemeyer explains. “Kidneys are simpler as they filter waste. The liver, however, is unique as it synthesizes a variety of proteins essential for numerous metabolic functions.”

Similar early successes were noted in heart and kidney transplants, although subsequent complications arose. In the realm of heart transplantation, risks potentially include the spread of swine viruses.

Recently, Hokujo Taiyo and colleagues at Anhui Medical University reported a pig liver transplant performed on a 71-year-old man. His liver was deemed too damaged for a traditional transplant due to severe tumor growth and significant scarring from hepatitis B. Thousands perish annually awaiting liver transplants, so each surgical case must be meticulously justified, according to Sun.

However, Sun indicated that the man required some form of transplant as there was a risk of the tumor rupturing, which could be life-threatening. With the patient’s consent, Sun and his team replaced the affected portion of the liver with one harvested from an 11-month-old minipig in May 2024. During a five-hour procedure, they connected the blood vessels of the pig liver to those of the left side of the recipient’s own liver.

To mitigate the risk of rejection by the immune system, three pig genes were disabled while seven human genes were introduced, enhancing compatibility. The patient was also administered immunosuppressants while the team diligently examined his liver to ensure it was free from swine viruses.

Almost immediately post-surgery, the new liver began to produce bile. Bile is crucial for the digestion of fats. Within weeks, levels of bile and albumin (a protein that retains fluid within blood vessels) in the patient rose to healthy ranges, as reported by Sun.

Nevertheless, about a month post-transplant, a life-threatening blood clot formed in a blood vessel, necessitating the removal of the graft. This complication likely stemmed from an overactive immune response, leading to abnormal blood-clotting protein levels—a challenge that may be common in pig transplants given the biological differences between species.

The patient lived for roughly five additional months with only the left side of his liver remaining before succumbing to gastrointestinal bleeding, a frequent issue associated with liver scarring, according to Sun. Both Sun and Wedemeyer believe this bleeding was probably not related to the transplant.

Despite the outcome, the operation is seen as a partial success because the patient would likely have died very soon after the tumor’s removal, noted Wedemeyer. Furthermore, he added that the patient’s liver may have partially regenerated during the successful functioning of the transplant, enabling survival for several months after the graft removal.

Wedemeyer emphasized that this procedure enhanced the understanding of xenotransplantation and opened up the possibility of pig livers providing temporary solutions for patients awaiting human transplants. There may even be a chance that the remaining liver tissue could grow sufficiently to negate the need for further treatment, indicated Sun.

However, Sun cautioned that it may take at least ten years before pig livers can replace human livers permanently. He stressed the need to minimize potential complications through further genetic advancements.

topic:

Source: www.newscientist.com

After a record-breaking 130 days, doctor successfully removes pig kidneys from Alabama woman

Posted on by
Reply

An Alabama woman lived with pig kidneys for a record-breaking 130 days before her body began rejecting them, leading to their removal and a return to dialysis, doctors announced Friday.

Following her removal surgery on April 4 at Nyu Langone Health, Towana Rooney steadily recovered and went back to her home in Gadsden, Alabama. Rooney expressed gratitude to the doctors for allowing her to take part in the study.

Rooney stated, “While the outcome was not what anyone would have hoped for, I have learned a great deal from having pig kidneys for 130 days. I believe this experience can benefit and inspire many others on their journey to overcome kidney disease.”

Scientists are working on genetically modifying pigs so that their organs are more similar to human organs, addressing the significant shortage of transplantable human organs. With over 100,000 people on the US transplant list, most in need of kidneys, and thousands waiting and dying, this advancement is crucial.

Prior to Rooney’s transplant, only four other Americans had received experimental xenotransplants using gene-edited pig organs – two hearts and two kidneys – all of which failed within two months. The recipients, who were severely ill before the surgery, did not survive.

Currently, researchers are attempting to transplant these pig organs into patients with less severe illnesses, like Rooney. A man from New Hampshire who received pig kidneys in January is doing well, and a comprehensive study of pig kidney transplants is scheduled for this summer. A Chinese researcher also reported successful renal xenotransplants recently.

Since 2016, Rooney has been on dialysis and was ineligible for conventional transplants due to her body’s predisposition to reject human kidneys. Turning to pig kidneys proved successful for her, allowing her to extend her life significantly. She referred to herself as a “superwoman” and lived longer than anyone with gene-edited pig organs before her body began rejecting them in early April.

Dr. Robert Montgomery, a pioneer of Nyu XenoTransplant and Rooney’s surgeon, stated that the rejection is being investigated. He emphasized that removing the pig kidneys was a safer option than continuing with high-risk rejection drugs.

Montgomery explained, “We took a safe approach. Rooney is not worse off post-XenoTransplant. In fact, she feels better as she had a four-month break from dialysis.”

Prior to the rejection, Rooney experienced infections associated with dialysis, while her immunosuppressive anti-rejection drugs were slightly reduced, allowing her immune system to revitalize after the transplant. These factors likely contributed to the rejection of the new kidneys.

Rejection is a common concern following organ transplants, which can result in the loss of new organs. Doctors must strike a delicate balance between suppressing the patient’s immune system, fighting infections, and maintaining the new organs.

This challenge is even greater with xenotransplants, where patients still require immunosuppressive medications despite modifications made to pig organs to prevent immediate rejection. Researchers are exploring different combinations of medications to find the most effective approach.

Montgomery believes Rooney’s experience will yield valuable insights for future clinical trials. Achieving successful xenotransplants would be a significant achievement with benefits for patients in need of organ transplants.

Source: www.nbcnews.com

Oldest living recipient of pig organ transplant in Alabama is a woman

Posted on by
Reply

An Alabama woman achieved a significant milestone on Saturday by becoming the longest surviving recipient of a pig organ transplant. After receiving a new kidney, she has been healthy and full of energy for 61 days.

Twana Rooney, who jokingly referred to herself as a “superwoman,” shared with The Associated Press her excitement about her recovery as she took a long walk through New York City. She expressed that the transplant has given her a fresh perspective on life.

Rooney’s remarkable progress following the transplant has provided hope in the advancement of animal-to-human organ transplants. While only four other individuals in the United States have received experimental pig organ transplants (including two hearts and two kidneys), none of them survived for over two months.

Dr. Robert Montgomery of Langone Health, who led Rooney’s transplant, expressed that her kidney function is now “absolutely normal.” The medical team is optimistic about her continued progress, enabling her to eventually return to her home in Gadsden, Alabama.

There is ongoing research involving genetically modified pigs to create more human-like organs to address the critical shortage of transplantable human organs in the US. With over 100,000 people on the US transplant waiting list, most in need of a kidney, and thousands dying while waiting, pig organ transplants have been implemented as acts of compassion.

Hospitals conducting these transplants are collaborating to share insights on the outcomes, paving the way for an upcoming formal study. United Therapeutics, the provider of Rooney’s kidney, has recently sought FDA approval to commence a trial.

Rooney’s experience of donating a kidney to her mother in 1999, subsequent pregnancy complications, and eight years on dialysis led her to explore pig organ transplants. Her journey has been closely monitored by medical professionals, demonstrating the possibility of successful long-term pig organ functionality in humans.

As an advocate and source of support for those navigating the transplant process, Rooney aims to inspire and educate others through her unique story. While the longevity of her new kidney remains uncertain, her resilience and determination offer hope for the future of organ transplantation.

Source: www.nbcnews.com

Families of individuals who passed away following pig organ transplants are at peace with their decision.

Posted on by
Reply

David Bennett Jr. knelt at his bedside, phone in hand, anxiously waiting for the call he’d never received before: The hospital was supposed to update him on whether his father, who had received a new heart transplanted from a pig, was still alive.

It was the first time a living human had received a pig organ transplant.

“I don’t know what the news is, but my dad opened his eyes, he was awake and he was OK. It was unbelievable,” Bennett Jr. said.

Bennett’s father, David Bennett Sr., had severe congestive heart failure and was not a candidate for a transplant. He knew he would likely die soon. There was nothing else he could do but take a chance on a novel, cutting-edge procedure. Bennett Sr. and his son agreed it was worth the risk.

The achievement made headlines around the world following the transplant in January 2022. Initially, the results looked promising, with some family members beginning to entertain the idea that Bennett Sr. might eventually be released from the hospital.

“There were definitely future-oriented conversations about the home environment, who was going to care for him and what that was going to look like,” Bennett Jr. said. “Everyone was very optimistic and hopeful.”

David Bennett Jr. and his family.
Jesse Barber, NBC News

But two months later, Bennett Sr.’s body rejected the heart and he died at age 57. paperDoctors at the University of Maryland Medical Center said his body likely produced too many antibodies to fight the new organ. The drugs he was given may have also increased the chance of rejection, and a virus in the pig’s heart further complicates things.

Three other patients have followed in Bennett Sr.’s footsteps and received pig organs, most recently a pig kidney transplant in April. Together, they are pioneers in the burgeoning field of xenotransplantation. For them, the journey has been a roller coaster of emotions, from anxiety to blind hope and ultimately praise for their loved one’s decision, three family members told NBC News.

“Obviously, I wish my dad was still here, but I know his sacrifice was not in vain,” Bennett Jr. said.

None of the patients survived more than three months. To the public, it may have seemed a failure. But to their families, the transplants had accomplished a goal: to buy their loved ones more time and to advance research that may one day save their lives.

“Larry thought: He’s going to die. It’s inevitable, it’s coming,” says Anne Fawcett, whose husband of nearly 38 years, Laurence Fawcett, is the second person to receive a pig heart transplant. “So to gather as much data as we can, to do as much research as we can, why not use Larry’s body as a test subject, to give people in the future who need a transplant another option?”

The potential of xenotransplantation lies in the shortage of available human organs. 17 people die every day in the United States while waiting for an organ transplantBecause pig organs are more readily available, doctors expect such surgeries to become as common as hip replacements in the future, according to the Health Resources and Services Administration.

Source: www.nbcnews.com

Oldest known narrative art is a pig painting dating back 50,000 years

Posted on by
Reply

Traces of cave paintings depicting pigs and human-like figures from Leang Karampuang, Sulawesi, Indonesia

Griffith University

An Indonesian cave painting depicting a pig with a human-like figure dates back at least 51,200 years and is known to be the oldest known example of figurative art in the world.

“I like to define us as a storytelling species, and this is the earliest evidence of that.” Maxime Oberle Griffith University, Gold Coast, Australia.

The pig artwork was discovered on the ceiling of a limestone cave in Leang Karampuang, Sulawesi, in 2017.

In 2019, Obert and his colleagues dated a hunting scene discovered in a nearby cave called Leang Bru Shipon 4 to at least 43,900 years ago.

Now, researchers have used new, more precise techniques to date both works of art, finding that the paintings at Reang Bulu Siphon 4 are actually more than 4,000 years older than previously thought, and the artwork at Reang Karampuan is even older.

According to Obert, the artwork at both sites predates the oldest known rock art in Europe by at least 10,000 years.

Modern people, Homo sapiens“We know they were in the area at that time, because they reached Australia by 60,000 to 65,000 years ago,” Obert said. “We think these art works were done by modern humans.”

The same cave contains depictions of creatures with both human and animal attributes, indicating spiritual beliefs.

“These rock art are not just little symbols,” team members say. Renaud Joanne Boyau “They were actually depicting scenes from the hunt and life, and were already using art to tell stories, inhabit a spirit world and try to make sense of their environment. This tells us a lot about human evolution,” said researchers from Southern Cross University in Lismore, Australia. Homo sapiens.”

Previous methods for dating artworks relied on chemical extraction of samples, which required crushing and destroying large portions of the rock.

The new technique involves taking a 5-millimeter-diameter core from the rock’s crust. A laser is used to remove material from the surface of this core, less than half the thickness of a human hair, which is then examined to measure the isotopic decay of the minerals. Once this is done, the core can be inserted into the rock art, much less disruptive than traditional methods.

Karampuang Hills, Reang Karampuang Cave site

Google Arts & Culture

Joannes Boyau says the new technique could lead to a major revision of the history of rock art around the world.

Kira Westaway Researchers from Macquarie University in Sydney, Australia, say improved dating methods have allowed them to more accurately assess when the Sulawesi art was actually created.

“This is really significant given that the first period was already considered groundbreaking,” she says. “This has huge implications for understanding the capabilities of these early artists who passed through Indonesia and the types of skills and tools they already had when they entered Australia.”

Homo sapiens They probably weren’t the only species with complex symbolic practices. Martin Pore “It is highly likely that other hominins had at least some capabilities in this regard, as can be inferred from the highly sophisticated material culture of Neanderthals,” say researchers from the University of Western Australia.

“It will be important to study further archaeological evidence from this region in the future to understand and confirm the social, economic and cultural context of these statues during the Late Pleistocene,” Poa said.

topic:

Source: www.newscientist.com

Researchers Successfully Grew Human Kidneys in Pig Embryos

Posted on by
Reply

Research led by Liangxue Lai from China’s Guangzhou Institute of Biomedical and Health Research has successfully extended the survival time of human stem cells in animal embryos. The team is focused on a five-year project to cultivate human organs for transplantation, bypassing the need for donor organs. To date, no scientist has been able to grow an organ within an animal embryo composed entirely of human cells.

Utilizing pig embryos due to their physiological and developmental similarities to humans, Lai’s team injected human stem cells into pig embryos. By deactivating specific genes in the pig embryos responsible for organ development, human stem cells could replace pig cells during organ growth.

The team also applied a small amount of the antibiotic doxycycline to the embryos, allowing them to control the activation of genes in the stem cells. This antibiotic helped activate genes that enhanced the survival and development of stem cells within the embryo, increasing the likelihood of organ formation.

The research aimed at growing kidneys, which are frequently transplanted organs and among the first to develop in human fetuses. The team implanted about 2,000 pig embryos into 13 surrogate pigs, resulting in kidney development within 20 days. After full growth, the embryos were analyzed for human stem cell content.

Despite efforts to minimize cell death, only a few embryos survived. Genetic testing confirmed the presence of human genetic sequences in the surviving embryos, indicating the potential for organ development from human stem cells within the pig embryos.

While the embryos showed signs of developing human kidneys, compatibility issues were identified, and human cells were found in other parts of the fetus’s body. The researchers concluded that the technique shows promise for growing human-compatible organs in the future.


Post views: 162

Source: sciworthy.com

First-ever pig kidney transplant performed on a living human

Posted on by
Reply

The kidney transplant surgery is the first of its kind in a living person.

Michelle Rose/Massachusetts General Hospital

Surgeons successfully transplanted a pig kidney into a 62-year-old man with end-stage renal disease. Recipient Richard Suleiman is recovering well and is expected to be discharged from the hospital soon, just a few days after surgery.

Is this your first pig kidney transplant?

This is the first time a pig kidney has been transplanted into a living human, marking a major milestone in the field of xenotransplantation, or transplanting animal organs into humans.

“This successful transplant is the culmination of decades of hard work by thousands of scientists and doctors.” Tatsuo Kawai At Massachusetts General Hospital statement. “Our hope is that this transplant approach will provide a lifeline to the millions of patients around the world suffering from kidney failure.”

However, strictly speaking, this is not the first time a kidney has been transplanted from a pig to a human. This surgery has been performed five times in the past, each time on a person declared brain dead and placed on life support. The most recent of these was conducted by Robert Montgomery and colleagues at New York University Langone Health in July 2023. The kidney continued to function for over a month with no signs of rejection or infection.

When was the surgery performed?

Kawai and his colleagues performed the surgery on March 16th. reported that the procedure lasted four hours, and shortly thereafter the kidneys began producing urine and the waste product creatinine. new york times. Suleiman was also able to stop dialysis, which is a further indication that his kidneys are functioning properly.

Where do pig kidneys come from?

The organs were donated by the pharmaceutical company EGenesis. The company breeds pigs that are genetically engineered to carry certain human genes and lack a specific set of pig genes that are harmful to humans. These genetic modifications reduce the chance of transplant rejection, where the immune system attacks the organ and causes it to malfunction. Suleiman is also being given a cocktail of immunosuppressants to further reduce this risk. So far, there are no signs of rejection and Suleiman is able to walk on his own. His doctors hope he will be discharged soon.

What do we know about the recipient?

Suleiman has type 2 diabetes, high blood pressure, and kidney disease. He had previously received a human kidney from a donor in December 2018. However, the organ showed signs of malfunctioning after about five years. He started dialysis in May last year, but complications arose, and he needed to go to the hospital every two weeks. This seriously affected his quality of life while awaiting his second transplant.

is more than 100,000 people in the US They are waiting for organ transplants, and 17 of them die every day. The U.S. Food and Drug Administration approved the experimental transplant for Suleiman due to a lack of other treatment options.

“I saw it as a way not only to help me but also to give hope to the thousands of people who need transplants to survive,” Suleiman said in a statement.

Have xenotransplant surgeries involving other organs been performed?

Only two other people received xenotransplants, and both received genetically modified pig hearts. The first, a man named David Bennett, died two months later from complications believed to be caused by a swine virus called porcine cytomegalovirus. So scientists genetically inactivated a virus similar to the pig virus from which Suleiman's kidneys came.

The second recipient, a man named Lawrence Fawcett, died six weeks later from transplant rejection.

topic:

Source: www.newscientist.com