Tag Archives: produces

Miraculous Recovery: Man Saved by Fecal Transplant After Intestine Produces Alcohol

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A corrective approach to alter a man’s microbiome prevented excessive alcohol production in his body.

Science Photo Library / Alamy

A Massachusetts man experienced severe inebriation due to his intestines autonomously producing alcohol, a condition known as autobrewer syndrome. His recovery began after ingesting fecal bacteria from a healthy donor.

This retired U.S. Marine, in his 60s, faced unusual symptoms following multiple antibiotic treatments for prostate inflammation. Until then, he maintained good health and only occasionally drank alcohol. His sudden, overwhelming intoxication left him disoriented and lethargic.

He sought help at emergency rooms repeatedly, but medical staff were skeptical about his claims of not drinking. Eventually, a diagnosis of autobrewer syndrome—a rare condition where gut microbes produce excessive alcohol—was confirmed.

His severe inebriation hindered routine activities, and he even required breathalyzer locks on his vehicles to avoid legal issues.

After connecting with a patient support group, he discovered fecal transplants could potentially treat his condition. This led him to contact Dr. Elizabeth Homan from Massachusetts General Hospital.

Initially, Dr. Homan dismissed his voicemail messages, as he sounded intoxicated. Eventually, the man’s wife reached out, explaining the situation, which prompted a collaboration with Dr. Bernd Schnabl, an expert on autobrewer syndrome. Together, they planned a fecal transplant for him.

Prior to the procedure, Homan, Schnabl, and their team conducted a comprehensive study on the causes of autobrewer syndrome. They analyzed stool samples from 22 patients with the condition and 21 healthy relatives, looking for variations in gut bacteria. “Our lab had a distinct smell,” Schnabl recollects.

The research revealed that fecal samples from patients produced significant alcohol when cultured, likely due to high levels of specific intestinal bacteria such as Escherichia coli and Klebsiella pneumoniae, which ferment sugars to create alcohol. Previous cases had primarily linked the syndrome to excessive yeast growth.

To treat the Massachusetts man, Homan administered oral capsules derived from a healthy male donor’s fecal matter, known for having an optimal gut microbiome. “This donor has been carefully selected and is a personal trainer who prioritizes fitness,” she explains. When the capsules were analyzed, researchers noted exceptional gut microbiota within them.

Gradually, the man’s autobrewer syndrome resolved as the harmful alcohol-producing bacteria in his gut were replaced with healthier strains from the donor. “One of the highlights of this case was meeting his daughter, a medical school graduate, who expressed gratitude for bringing her ‘old dad back,'” Homan shared.

Schnabl mentions that most individuals likely produce minimal alcohol in their intestines due to the presence of Escherichia coli and Klebsiella pneumoniae. However, significantly elevated levels lead to inebriating alcohol production, often triggered by long-term antibiotic use that disrupts the microbiome, which was the case for this patient.

Currently, Homan and Schnabl are conducting a large-scale trial to assess the effectiveness of oral fecal transplants for other patients with autobrewer syndrome.

Topics:

  • Gut Health /
  • Intestinal Microbiota

Source: www.newscientist.com

Queen Ant Produces New Male Species for Daughter’s Mating

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Male ants of distinct species laid by the same mother: Messor ibericus (left) and Messor structor (right)

Jonathan Romiguier

In the clutches of the Iberian Harvester Ant queens, another male species, the Builder Harvester Ant, emerges. These males are responsible for siring all the workers in the colony.

“This assertion appears utterly unbelievable, akin to the impossible,” remarks Jonathan Romiguier from the University of Montpellier, France. Nonetheless, he has confirmed its validity.

Romiguier’s curiosity was piqued by the Iberian harvester ants (Messor ibericus) after he discovered that all the workers were hybrids. About half of their DNA aligned with that of the builder harvester ant (Messor structor).

The most plausible explanation is that the queen of M. ibericus mated with a male of M. structor. This occurrence is seen in other ant species. The reasons remain unclear, but two main theories have emerged. One is that hybrids of closely related species could benefit from what’s known as hybrid vigor, where various genes can compensate for each other’s deficiencies.

Another theory suggests this may address a peculiar challenge faced by M. ibericus and several other harvester ant species: whenever M. ibericus queens mate with males of their own species, all offspring become queens. This might stem from a genetic tendency to secure their lineage, but it becomes detrimental for colonies that need worker ants for survival. Breeding with another species may provide a solution.

However, M. ibericus colonies are widespread across various Mediterranean locales, unlike M. structor colonies, which are exclusive to Sicily. Nonetheless, Romiguier and his team encountered peculiar, hairless males of M. structor within an M. ibericus nest. So, where did they originate?

The genetic examination of these unusual males yielded perplexing insights. A tiny segment of the mitochondrial DNA—passed solely from the mother—indicated that these males derive from the M. ibericus queen.

This hinted that the eggs produced by the queen of M. ibericus could encompass males of a different species. To verify this theory, Romiguier brought several M. ibericus colonies into his lab. “Under laboratory conditions, it’s nearly impossible to find a male,” he comments. “We maintained about 50 colonies and observed one male for two years without success. Then, fortune smiled upon us.”

From three M. structor males born in the lab, the evidence was undeniable: the queen of M. ibericus produced males from both species. The only explanation for this phenomenon is that the queen ant cloned M. structor males using stored sperm in specialized organs called spermathecae. The resulting eggs were almost entirely devoid of M. ibericus DNA, except for its mitochondrial component.

This also clarifies the origin of M. structor sperm: by producing two types of males, the queen guarantees that her daughters who evolve into queens can mate with both male types. The females use M. ibericus sperm to generate new queens, while M. structor sperm is utilized for hybrid workers and new male ants.

There are notable instances from other species—including ants, mollusks, and stick insects—where female eggs are manipulated by male sperm from different species, leading to the elimination of egg DNA and the production of unrelated individuals. However, this scenario mainly benefits males. This is the sole known instance where both male and female offspring from distinct species rely on each other for reproduction.

“The queen of M. ibericus is entirely dependent on her cloned males. Without them, she cannot produce workers,” states Romiguier. Moreover, the clones of M. structor need the males of M. ibericus for rearing workers and sustaining their colonies—there is no sign that they mate exclusively within their species.

While these findings may seem far-fetched, they have garnered the support of other specialists. “The researchers conducted thorough investigations into these ants,” comments Nathan Law from the University of Sydney. “Their results robustly affirm their conclusions.”

He speculates that cloned males could accumulate harmful genetic mutations that may not be purged over time due to the lack of interbreeding with other strains. “Eventually, this system may start to decline, especially as environmental conditions shift.”

Romiguier agrees that this exceptional situation might eventually lead to collapse. Yet, at present, it appears that M. ibericus and M. structor have navigated their relationship with ingenious adaptability, propelling their expansion throughout the Mediterranean, while M. structor colonies have not established themselves elsewhere.

Insects and Ecosystem Expedition Safari: Sri Lanka

A voyage into the depths of Sri Lanka’s vast biodiversity through a unique entomology and ecosystem-centered expedition.

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Source: www.newscientist.com

Study Finds One Nation Produces Its Entire Food Supply.

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According to a recent study, out of 186 countries, only Guyana is capable of producing sufficient food for itself without relying on foreign imports.

This study, published in Natural Food, assessed how effectively countries can supply their populations with seven food groups: fruits, vegetables, dairy products, fish, meat, plant-based proteins, and starchy staples.

Globally, the research revealed that 65% of countries produce meat and dairy in alignment with their population’s dietary needs.

It also determined that Guyana, situated in South America, stands as the sole country achieving complete self-sufficiency, while China and Vietnam can sufficiently produce food across six out of the seven food groups.

However, only one in seven individuals in the surveyed countries was deemed self-sufficient in five or more categories.

Surrounded by lush greenery, Guyana was identified as the only nation in this study that produces enough food to nourish its people across all seven food groups. – Credit: Jonas Stehl, Nature Food 2025, doi: 10.1038/S43016-025-01173-4 Data published

Meanwhile, there is a global deficiency of nutrient-dense plants, as fewer than half of the countries involved in the study produce adequate plant-based proteins, such as beans, chickpeas, lentils, nuts, and seeds, as well as sufficient starchy carbohydrates and vegetables.

Europe and South America tended to be closer to achieving self-sufficiency compared to other regions. In contrast, small island nations, countries in the Arabian Peninsula, and low-income nations were more likely to depend on food imports.

Six nations—Afghanistan, the United Arab Emirates, Iraq, Macau, Qatar, and Yemen—produced inadequate food groups to be categorized as self-sufficient.

“Low self-sufficiency is not inherently negative,” stated Dr. Jonas Stehl, a researcher from Göttingen and the first author of the study, in an interview with BBC Science Focus. “There are effective and often advantageous reasons why a country may not meet all its food production needs.”

For instance, a country may lack sufficient rainfall, quality soil, or stable temperatures necessary for growing adequate food for its population.

Stehl added that importing food from suitable regions can also be cost-effective.

“However, low levels of self-sufficiency can compromise a country’s ability to respond to sudden global food supply shocks, such as droughts, conflicts, and export bans,” he noted.

A team from the University of Göttingen in Germany and the University of Edinburgh in the UK conducted the study, evaluating the food output of various countries.

The researchers compared this data to the nutritional needs of each nation’s citizens, referencing the World Wildlife Fund’s Livewell Diet.

The Livewell Diet recommends “a flexible eating pattern that emphasizes plant-based protein sources, consumes vegetables, legumes, whole grains, and limits foods high in fat, salt, and sugar.”

The Covid-19 pandemic and the onset of the Russia-Ukraine conflict have sparked discussions about the merits of self-sufficiency, as these global crises have disrupted consistent food supplies to importing countries.

Stehl concluded that “the increased attention on national food self-sufficiency may signal broader political changes.”

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About Our Experts

Dr. Jonas Stehl is a doctoral researcher at the University of Göttingen in Germany, focusing on the food system and its implications for sustainability, nutrition, and health from a global viewpoint. He is part of an interdisciplinary research training group named Sustainable Food Systems. Stehl’s research interests include development, health, the environment, group economy, nutrition, and food security.

Source: www.sciencefocus.com