Tag Archives: drops

Nasal Drops: A Potential Solution for Preventing All Strains of Influenza

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Nasal Sprays Target the Main Entry Point of the Influenza Virus

Tatyana Maksimova/Getty Images

Recent research highlights a novel antibody nasal spray that showed promise in early trials with mice, monkeys, and humans for preventing influenza infections. This spray can neutralize various strains of influenza viruses, including those transmitted from animals, potentially aiding in the fight against future pandemics.

The primary method of combating the spread of influenza remains the annual vaccine, designed to stimulate the immune system to produce targeted antibodies against circulating virus strains. However, due to the constant mutations of influenza viruses, vaccines can only offer limited protection.

To enhance vaccine efficacy, pharmaceutical innovator Johnson & Johnson has developed a groundbreaking antibody, CR9114, capable of neutralizing diverse influenza strains. This antibody recognizes and binds to invariant components of the virus, allowing for consistent defense against mutations.

Initially, CR9114 was injected into animals, but it didn’t provide adequate protection due to insufficient concentrations reaching the nasal cavity—the virus’s primary point of entry. In 2022, the Leiden Institute licensed CR9114, creating a formulation suitable for nasal administration.

Subsequent studies demonstrated that administering CR9114 via nasal spray to mice and macaque monkeys shielded them from various influenza A and B strains, including one isolated during the 1933 flu outbreak.

In addition, preliminary tests involving 143 individuals aged 18 to 55 revealed that using the nasal spray twice daily maintained steady antibody levels in their nasal passages, showing no significant side effects. Mucus samples collected afterward successfully neutralized different strains of influenza, including the avian flu strain that affected humans in China in 2013.

The next phase of research will expose nasal spray users to live influenza viruses to determine its actual effectiveness in preventing illness.

While nasal sprays may not guarantee 100% effectiveness against all entry routes of the virus, they remain a crucial defense mechanism against influenza. According to Linda Wakim from the University of Melbourne, “Even if you block entry through the nose, you’ll still be eliminating the virus at its main access point for infection.”

Wakim also notes that while the nasal spray may require more frequent dosing than a standard flu shot, it could significantly benefit high-risk populations, such as immunocompromised individuals and frontline health workers, especially during pandemics when rapid public health responses are essential.

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Source: www.newscientist.com

What Happens When Your Stomach Drops on a Roller Coaster

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While the exact reason remains uncertain, that “fast stomach” sensation you feel on a roller coaster, during a sudden drop on a lift, or when hitting a large bump in a car highlights how your body reacts to rapid shifts in movement and gravity.

Your organs are generally anchored by a network of tissues and muscles, with gravity constantly pulling everything downward. However, when you encounter a dip or bump, the sudden changes in speed and direction—especially a quick descent—can create a distinct experience.

In that instant, your organs do not descend at the same rate as the rest of your body, resulting in a brief moment of weightlessness akin to what astronauts experience in space.

The sharp turns and swift drops of a roller coaster can induce a bit of dizziness. – Illustration credits: James Clapham

Your stomach and intestines are relatively mobile, which is why these areas are more prone to the sensation. Since they are loosely suspended, they lag slightly behind when your body moves downward rapidly.

Nerves surrounding these organs react to their displacement, sending signals to your brain that create those peculiar, stomach-flipping feelings. This sensation is enhanced by the vestibular system in your inner ear.

The vestibular system struggles to adapt to the unexpected drops and shifts in direction, intensifying that disorienting feeling of “falling.” This explains why the quick curves and steep descents of roller coasters can also leave you feeling a bit dizzy.

So, the next time you experience that exhilarating rush, take a moment to appreciate the physics at play: gravity, acceleration, and the intricate balance of your internal organs contributing to the thrill.

This article answers a question sent to Lori Schafer: “Why does my stomach drop on a roller coaster or when I hit a bump?”

Please email us to submit your questions: Question @sciencefocus.com or Message Facebook, Twitter, or Instagram Page (don’t forget to include your name and location).

Check out our ultimate Fun fact and more amazing science pages.

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Source: www.sciencefocus.com

Investors React Poorly to CyberCab Self-Driving Car, Tesla’s Value Drops $60 Billion

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Tesla shares dropped almost 9% on Friday, erasing roughly $60 billion from the company’s market value following the underwhelming announcement of its highly anticipated robotaxis that failed to impress investors.

The electric vehicle manufacturer’s stock plummeted to $217 at the close of the market after CEO Elon Musk revealed a much-hyped self-driving car at an event in Hollywood. Since the start of the year, the stock price has declined by about 12%.

Musk stated that Tesla would commence the development of a fully autonomous CyberCab by 2026 priced under $30,000 and introduced a van capable of transporting 20 people autonomously within the city, aiming to revolutionize parking.

Prior to the event, he tweeted: “And within 50 years all transportation will be fully autonomous.”

During the presentation, he mentioned that parking would no longer be necessary in the city.

However, analysts were disappointed by the lack of specifics at the event concerning Tesla’s projects and other developments. Musk has a track record of making ambitious projections about future products that often fail to materialize within set deadlines or at all.

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Royal Bank of Canada analyst Tom Narayan remarked in an investor note that the event lacked specifics. He stated, “Investors we spoke to during the event felt that the event glossed over actual figures and timelines.”

“These shortcomings are common at Tesla events, which appear to focus more on promoting and branding Tesla’s vision rather than providing concrete data for analysis. Consequently, we anticipate a decline in the stock price.”

Narayan also mentioned that some investors were anticipating a preview of an affordable car equipped with pedals and a steering wheel set to be launched next year, but no such announcement was made.

Garrett Nelson, an analyst at investment research firm CFRA, expressed disappointment with the revelations about the CyberCab and the lack of information regarding more economical vehicles.

He said: “The event raised numerous questions but was surprisingly brief and resembled more of a controlled demonstration than a comprehensive presentation. We were unsatisfied with the absence of details about [Tesla’s] near-term product plans, which include a more affordable model and the Roadster. Musk previously mentioned on a conference call that production of these models is set for 2025.”

Source: www.theguardian.com

Saline nasal drops and sprays showing promise in treating the common cold

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Saline nasal sprays may stop children's sneezing faster

ONFOKUS.COM, Sebastian Court/Getty Images

Saline nasal sprays appear to help speed up cold recovery: In a new study, children who were given the homemade nasal spray recovered from cold symptoms like sneezing and stuffy nose two days faster than those who weren't.

More than 200 different viruses can cause cold-like symptomsTherefore, it is difficult to develop general and effective treatments that target them. As a result, most cold therapies only relieve symptoms but do not shorten the duration of symptoms.

But research increasingly suggests that saline may be the exception. Studies have shown that adults who use saline nasal drops or sprays to relieve cold symptoms: Reduces symptoms and speeds recovery and Less likely to spread infection.

now, Steve Cunningham Researchers at the University of Edinburgh in the UK tested this method on children. They asked the parents of 150 children with cold symptoms to place three drops of saline solution into their children's nasal passages at least four times a day within 48 hours of the onset of symptoms, until symptoms subsided. The water-based solution that the parents mixed themselves contained 2.6 percent salt.

Another group of 151 children received standard cold care from their parents, such as prescribing over-the-counter medicines and encouraging rest. All of the children were under the age of seven, and their symptoms were recorded by their parents.

The researchers found that children who started using the drops within 24 hours of the onset of symptoms recovered two days faster than those who never used the drops, and their families were also less likely to develop cold symptoms. But children who started using the drops later didn't get better and were less likely to spread the cold than those who never used the drops.

Cunningham, who will present his findings at the European Respiratory Society meeting in Vienna, Austria, on September 8, says that the chloride ions in saline could prompt cells to produce an antiviral substance called hypochlorous acid, though this may need to be started early in infection, before the virus can take hold, he says.

but William Shaffner Researchers at Vanderbilt University Medical Center in Tennessee are skeptical that this method will actually help cure viral infections. [evidence] They want me to believe that this is an antiviral effect, not just symptom relief,” he says.

Schaffner says the researchers could have also given another group of children regular water drops or a low-concentration saline solution, which would show whether the saline nasal spray targets the virus and speeds recovery or simply keeps mucous membranes moist to ease symptoms, he says.

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Source: www.newscientist.com

NVIDIA’s stock price drops as US ramps up antitrust probe

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Shares in AI chip designer Nvidia have been falling overnight following reports that US authorities are stepping up an investigation into whether the company has violated competition laws.

The company’s shares fell 2.4% in after-hours trading, supplementing a fall of nearly 10% in regular trading, sending its market capitalisation down by $279bn (£212bn) to $2.6trn, the biggest one-day fall ever for a US company.

Bloomberg reported that overnight, the Department of Justice sent subpoenas to Nvidia and other tech companies, taking steps to legally compel recipients to hand over information.

Nvidia executives are said to be concerned that the company is making it difficult for customers to switch to other semiconductor suppliers and penalizing buyers that refuse to give them exclusive use of Nvidia’s AI chips.

The moves mark an intensification of the U.S. antitrust investigation and bring the government one step closer to filing formal charges against Nvidia.

Tuesday’s sell-off came amid a market-wide sell-off sparked by weak U.S. manufacturing data that raised broader concerns among investors about the outlook for the U.S. economy. Manufacturing contracted at a moderate pace in August, with new orders, production and employment levels declining, according to the Institute for Supply Management’s monthly survey of factories.

That sent the S&P 500 down more than 2%, while the tech-heavy Nasdaq Composite Index fell nearly 3.3%. Uncertainty spread to Asia, where Japan’s Nikkei fell 4.2% on Wednesday and Australia’s S&P/ASX 200 index fell 1.9%.

This has exacerbated recent volatile trading for Nvidia and other AI-related stocks, including Google, Apple and Amazon, as investors worry that the real impact — and tangible benefits — of the much-touted AI revolution may still be a long way off.

Founded in 1993, Nvidia primarily designed chips for video games, but during the cryptocurrency boom it realized its processing technology could be used to mine digital coins. Since then, the company has shifted its focus to artificial intelligence, riding a new wave of excitement about the potential of large-scale language models.

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The company last week reported a 122% increase in second-quarter revenue, but signs of slowing growth, especially around its next-generation AI chip, code-named “Blackwell,” have spooked investors.

An Nvidia spokesman said: “We win on merit, as reflected in our benchmark results and value to customers, so they can choose the solution that’s best for them.”

Source: www.theguardian.com

Adobe drops support for Figma, Apple Watch sales paused, millions of accounts breached by hackers

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Welcome everyone to Week in Review (WiR). This is TechCrunch’s regular newsletter that recaps the top tech and tech-related stories from the past few days. With the holidays approaching, reporters expected a quiet week. But the opposite happened. I have no shortage of stories to write.

In this WiR, we learn that Comcast and Mr. Cooper’s customer data was stolen, electric scooter company Bird files for bankruptcy, Adobe ends its plan to acquire Figma, and Apple The report deals with the fact that the company is being forced to suspend sales by the International Trade Commission (ITC). apple watch. Also: Nikola founder Trevor Milton’s securities fraud conviction, Microsoft’s chatbot CoPilot now adding music-generating capabilities, and Consumer Reports’ impressions of Tesla’s Autopilot recall fix (spoiler: good news) We also highlight the

There are many things we need to overcome, so let’s do our best. But before that, if you haven’t already, here’s a reminder to subscribe here so you can receive his WiR in your inbox every Saturday.

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Hackers target Comcast: Comcast has confirmed that hackers who exploited a security vulnerability rated critical gained access to sensitive information of approximately 36 million Xfinity customers. The vulnerability, known as “CitrixBleed,” was discovered in Citrix networking devices commonly used by large enterprises and has been heavily exploited by malicious actors since August, Carly reports.

Mr. Cooper under fire: In related news, hackers stole sensitive personal information of more than 14.6 million of Cooper’s customers, Zack wrote. The mortgage and loan giant admitted that criminals stole customers’ names, addresses, dates of birth, and phone numbers, as well as social security numbers and bank account numbers.

Adobe gives up: Adobe finally makes a huge $20 billion bid to acquire rival Figma officially dead This comes after the companies announced this week that their acquisition plans had been scrapped due to regulatory resistance in Europe. The deal, first announced last September, has always attracted regulatory scrutiny due to its size and the fact that it removed one of Adobe’s major rivals from the shadows. Paul points out.

Apple stops selling Apple Watch: Apple has stopped selling its Series 9 and Ultra 2 smartwatches following an October ruling by the ITC over a patent dispute with California-based medical technology company Masimo. The controversy revolves around the blood sensor monitor in the latest flagship Apple Watch. Apple is appealing the ITC’s ruling.

Nikola’s founder declared: Trevor Milton, the disgraced founder and former CEO of electric truck startup Nikola, was sentenced Monday to four years in prison for securities fraud. Rebecca wrote that the ruling ended a years-long saga in which Nikola’s stock soared as much as 83% at one point, only to plummet months later amid fraud charges and contract cancellations.

The co-pilot learns the composition skill. Microsoft Copilot, Microsoft’s AI-powered chatbot, can now compose songs through integration with generative AI (GenAI) music app Suno. Users can enter prompts into Copilot, such as “Create a pop song about my adventures with my family,” and have her Suno bring their musical ideas to life through the plugin.

Tesla fixes ‘inadequate’: After the test, consumer report He said Tesla’s fixes for the Autopilot recall of more than 2 million vehicles were “insufficient.” Sean noted that while the test is not comprehensive, it shows that questions remain about Tesla’s approach to driver monitoring, the technology at the heart of the recall.

Bird files for bankruptcy: bird Submitted Under Chapter 11 Bankruptcy Code, capping off a turbulent year for the electric scooter company.in press releaseBird confirmed it had entered a “financial restructuring process aimed at strengthening its balance sheet” and said the company was continuing business as usual with the aim of “long-term, sustainable growth.”

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Want a listening ear as you prepare your holiday dishes? You’re in luck — TechCrunch’s podcasts are just the ticket.

this week’s capitalthe second in a two-part series looking back at 2023, in which our staff recapped the collapse of Silicon Valley Bank, the long and tedious trial of FTX founder Sam Bankman Fried, and the wild office politics of OpenAI .

meanwhile, found We focused on Charlie Hernandez and his journey building My Pocket Lawyer, an online platform aimed at giving people who can’t afford a lawyer democratic access to legal advice and guidance . Hernandez talked about why he decided to use his law degree to tackle this issue.

and Chain reaction Featuring Staci Warden, CEO of the Algorand Foundation, the organization behind the layer 1 blockchain Algorand. Algorand is a Singapore-based blockchain that aims to be fast, secure, decentralized, and “the greenest” with a carbon negative network.

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TC+ subscribers have access to in-depth commentary, analysis, and surveys. You probably know these if you’re already a subscriber. If not, please consider signing up. Here are some highlights from this week.

Etsy headcount reductions: Etsy recently announced it would lay off 11% of its workforce, which comes as no surprise to those who follow the e-commerce space closely, Anna writes. She predicts that “junkification” and fierce competition will chart a difficult future.

DEI backlash: Dom writes about the dispiriting backlash against DEI (diversity, equity, and inclusion), a framework for creating more conscious workplace efforts to support marginalized communities in the tech sector. I am.

Figma’s rosy outlook: Anna writes that things don’t seem too bad for Figma even without Adobe. CB Insights estimates that the startup’s value is still between $8.3 billion and $9 billion.

Source: techcrunch.com