Tag Archives: nasal

Nasal Drops: A Potential Solution for Preventing All Strains of Influenza

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Nasal Sprays Target the Main Entry Point of the Influenza Virus

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Recent research highlights a novel antibody nasal spray that showed promise in early trials with mice, monkeys, and humans for preventing influenza infections. This spray can neutralize various strains of influenza viruses, including those transmitted from animals, potentially aiding in the fight against future pandemics.

The primary method of combating the spread of influenza remains the annual vaccine, designed to stimulate the immune system to produce targeted antibodies against circulating virus strains. However, due to the constant mutations of influenza viruses, vaccines can only offer limited protection.

To enhance vaccine efficacy, pharmaceutical innovator Johnson & Johnson has developed a groundbreaking antibody, CR9114, capable of neutralizing diverse influenza strains. This antibody recognizes and binds to invariant components of the virus, allowing for consistent defense against mutations.

Initially, CR9114 was injected into animals, but it didn’t provide adequate protection due to insufficient concentrations reaching the nasal cavity—the virus’s primary point of entry. In 2022, the Leiden Institute licensed CR9114, creating a formulation suitable for nasal administration.

Subsequent studies demonstrated that administering CR9114 via nasal spray to mice and macaque monkeys shielded them from various influenza A and B strains, including one isolated during the 1933 flu outbreak.

In addition, preliminary tests involving 143 individuals aged 18 to 55 revealed that using the nasal spray twice daily maintained steady antibody levels in their nasal passages, showing no significant side effects. Mucus samples collected afterward successfully neutralized different strains of influenza, including the avian flu strain that affected humans in China in 2013.

The next phase of research will expose nasal spray users to live influenza viruses to determine its actual effectiveness in preventing illness.

While nasal sprays may not guarantee 100% effectiveness against all entry routes of the virus, they remain a crucial defense mechanism against influenza. According to Linda Wakim from the University of Melbourne, “Even if you block entry through the nose, you’ll still be eliminating the virus at its main access point for infection.”

Wakim also notes that while the nasal spray may require more frequent dosing than a standard flu shot, it could significantly benefit high-risk populations, such as immunocompromised individuals and frontline health workers, especially during pandemics when rapid public health responses are essential.

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Source: www.newscientist.com

Study Suggests Common Nasal Antihistamine Sprays Could Help Prevent Community Infections

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Nasal sprays available over-the-counter, historically noted for their safety and efficacy in treating seasonal allergies, could be perceived in a new light following clinical trial results released on Tuesday.

The antihistamine azelastine has been observed to have antiviral properties against various respiratory infections, including Influenza, RSV, and viruses responsible for COVID, according to a growing body of research.

Researchers from Saarland University Hospital in Germany conducted a study involving 450 adults, predominantly in their early 30s. One group of 227 participants used a nasal spray three times daily, while the other 223 received a placebo spray under the same regimen.

Throughout nearly two months, all participants underwent COVID rapid testing twice weekly. The results indicated that the incidence of symptomatic infections was 2.2% in the azelastine group, markedly lower than the 6.7% infection rate in the placebo group.

Furthermore, azelastine seemed to diminish the incidence of other symptomatic respiratory infections, as highlighted in a study published in JAMA Internal Medicine.

While researchers remain uncertain about the exact mechanism by which azelastine limits infections, they hypothesize that it may bind to the virus in the nasal mucosa.

Another possibility is that azelastine interacts with the ACE2 receptor, the primary entry point for COVID viruses into human cells, thereby preventing their attachment.

“Our findings imply that azelastine could serve as a scalable and commercially viable preventive measure against COVID, especially in high-risk scenarios such as crowded indoor events and travel,” the researchers noted.

However, the study had limitations, including that all participants were relatively young and healthy, according to the researchers.

Valz emphasized that azelastine should not replace vaccination and further research is essential before considering it as a standard precautionary measure for the public, particularly for vulnerable groups.

Dr. William Messer, associate professor at Oregon Health & Science University, found the results “rationally convincing” in terms of risk reduction, but pointed out the intensive regimen of daily sprays in the trial.

He questioned whether wearing a mask might be a simpler approach to preventing COVID infection.

“Masks can be inconvenient and bothersome, yet may be easier to adhere to than remembering to use three nasal sprays daily,” Messer remarked.

Nevertheless, he added, “I do not discourage anyone who wishes to try it.”

Other researchers are seeking more data to ascertain the effectiveness of nasal sprays in high-risk populations, such as the elderly and immunocompromised individuals who require additional preventive measures.

Dr. Peter Chin-Hong, a professor at UCSF Health specializing in Infectious Diseases, speculated that azelastine could serve as an additional COVID-blocking tool for individuals already using nasal sprays for seasonal allergies, although he believes the evidence is insufficient for broader recommendations.

“While the potential is promising, I believe now is not the appropriate time to recommend it as a COVID preventative,” he stated in an email. “For those over 65, I continue to advocate for vaccination as the primary defense against COVID.”

Nonetheless, Chin-Hong highlighted that the trial results underscore the importance of targeting the nasal mucosa in developing future vaccines against COVID and other respiratory viruses as a more effective means of infection prevention.

“Current COVID vaccines have not proven to be highly effective in preventing infection,” he remarked. “There is a need for more mucosal vaccines for respiratory viruses. While flu vaccines are widely used, ongoing efforts are being made to create mucosal vaccines for coronaviruses, necessitating continued advocacy for federal support and prioritization for these initiatives.”

Source: www.nbcnews.com

Study suggests nasal fungus may be the cause of your allergies

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It’s that time of the year again when runny nose season has already arrived. However, for some people, runny noses are a year-round struggle due to allergies. In fact, an estimated 25-40% of people worldwide are affected by allergic rhinitis, a condition that causes inflammation of the nose’s mucous membranes.

So, what’s behind this constant sniffing? Scientists may have an answer: individuals with allergies harbor a variety of fungi in their noses.

Despite this discovery, the presence of any fungus in our noses is quickly countered by our immune system. We all have fungi in our nasal mycobiome, a diverse community of fungal microorganisms that reside in our nostrils and sinuses, contributing to our overall microbial diversity essential for maintaining a healthy immune system and fighting off harmful pathogens.

In a study on nasal mycobiome, researchers collected nasal swabs from 214 allergic patients and 125 healthy individuals. The swabs showed significant differences in the prevalence and diversity of nasal fungi between the two groups, with allergic patients exhibiting more abundant and diverse mycobiomes.

“These findings suggest that the nasal cavity serves as a reservoir for fungi that may contribute to allergic rhinitis,” said Dr. Luis Delgado, a Professor at the University of Porto, Portugal, and one of the authors of a new study published in 2006 in the journal Frontiers of Microbiology.

The study also identified specific metabolic pathways more common in the fungal communities of allergic rhinitis patients, potentially paving the way for future allergy treatments.

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Source: www.sciencefocus.com

Saline nasal drops and sprays showing promise in treating the common cold

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Saline nasal sprays may stop children's sneezing faster

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Saline nasal sprays appear to help speed up cold recovery: In a new study, children who were given the homemade nasal spray recovered from cold symptoms like sneezing and stuffy nose two days faster than those who weren't.

More than 200 different viruses can cause cold-like symptomsTherefore, it is difficult to develop general and effective treatments that target them. As a result, most cold therapies only relieve symptoms but do not shorten the duration of symptoms.

But research increasingly suggests that saline may be the exception. Studies have shown that adults who use saline nasal drops or sprays to relieve cold symptoms: Reduces symptoms and speeds recovery and Less likely to spread infection.

now, Steve Cunningham Researchers at the University of Edinburgh in the UK tested this method on children. They asked the parents of 150 children with cold symptoms to place three drops of saline solution into their children's nasal passages at least four times a day within 48 hours of the onset of symptoms, until symptoms subsided. The water-based solution that the parents mixed themselves contained 2.6 percent salt.

Another group of 151 children received standard cold care from their parents, such as prescribing over-the-counter medicines and encouraging rest. All of the children were under the age of seven, and their symptoms were recorded by their parents.

The researchers found that children who started using the drops within 24 hours of the onset of symptoms recovered two days faster than those who never used the drops, and their families were also less likely to develop cold symptoms. But children who started using the drops later didn't get better and were less likely to spread the cold than those who never used the drops.

Cunningham, who will present his findings at the European Respiratory Society meeting in Vienna, Austria, on September 8, says that the chloride ions in saline could prompt cells to produce an antiviral substance called hypochlorous acid, though this may need to be started early in infection, before the virus can take hold, he says.

but William Shaffner Researchers at Vanderbilt University Medical Center in Tennessee are skeptical that this method will actually help cure viral infections. [evidence] They want me to believe that this is an antiviral effect, not just symptom relief,” he says.

Schaffner says the researchers could have also given another group of children regular water drops or a low-concentration saline solution, which would show whether the saline nasal spray targets the virus and speeds recovery or simply keeps mucous membranes moist to ease symptoms, he says.

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Source: www.newscientist.com

The Nasal Bones of Arctic Seals Are Unusual and Aid in Heat Retention

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Bearded seals have complex nasal bones that help retain internal heat.

Ole Jorgen Rioden/naturepl.com

Arctic seals have evolved clever adaptations to help them stay warm in frigid climates. The nose has a complex maze of bones.

Many birds and mammals, including humans, have a pair of thin, porous nasal bones called turbinates or nasal turbinates, which are covered with a layer of tissue.

“They have a scroll shape or a tree-like branching shape,” he says. Matthew Mason at Cambridge University.

When we breathe in, air first flows through the maxillary turbinates, allowing the surrounding tissues to warm and humidify the air before it reaches the lungs. When we exhale, the air follows the same route, trapping heat and moisture so it doesn’t get lost.

The more complex the shape, the larger the surface area and the more efficient it is at doing its job.

Animals that live in cold, dry environments, such as arctic reindeer, have been found to have more complex gnathonasal turbinates than animals that live in warmer climates.

Now, Mason and his colleagues have discovered that arctic seals have the most complex gnathonasal turbinates ever reported.

Researchers took a CT scan of a bearded seal (Elignathus barbatus), commonly found in the Arctic, and the Mediterranean monk seal (monax monax). Both species had complex turbinates, but the researchers found that the bearded seal’s nasal bones were much denser and more complex than anything seen before.

Mason and his colleagues used computer models to measure how much energy is lost as heat in physical processes at -30°C and 10°C (-22°F and 50°F). We compared how well the seals retain heat and moisture.).

With each breath at -30°C, Mediterranean monk seals lost 1.45 times more heat and 3.5 times more water than bearded seals. Similarly, at 10°C, monk seals lost about 1.5 times more water and heat than arctic seals.

“More complex structures evolved to make life in the Arctic possible,” he says. Sign Kelstrup At the Norwegian University of Science and Technology.

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Source: www.newscientist.com