Pediatrician Develops Innovative Blood-Based Treatment for RSV and Common Cold

Pediatricians play a critical role beyond just treating children’s illnesses. A recent study highlights their blood as a valuable source for developing treatments for common childhood diseases.

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In the battle against common childhood diseases, researchers have looked at an unexpected asset: the blood of pediatricians. This blood contains a treasure trove of potent antibodies that can serve as effective preventive treatments. Shockingly, these antibodies surpass current approved therapies for respiratory syncytial virus (RSV) and typical cold viruses.

Pediatricians frequently encounter respiratory viruses, making them a potentially underutilized resource in the search for robust antibodies against these pathogens. While existing antibody treatments for RSV protect against some strains, the quest for broader-spectrum options continues.

A collaborative team led by Hui Zai at Chongqing Medical University Children’s Hospital analyzed the blood samples of 10 pediatricians with more than a decade of experience. This led to the identification of 56 exceptionally effective antibodies against RSV within the pediatricians’ immune cells.

Next, researchers engineered versions of these antibodies and conducted laboratory tests, discovering that three specific antibodies demonstrated significant efficacy against various strains of RSV. Remarkably, one of these antibodies also neutralized the human metapneumovirus, a virus closely related to RSV that is a frequent cold culprit but can lead to severe illness in certain children.

Subsequent studies involving mice and rats revealed that injections of these three pediatric-derived antibodies, either alone or in combination, prevented the emergence of symptoms in animals infected with RSV or human metapneumovirus. Notably, the pediatrician-derived antibody exhibited a blocking efficiency up to 25 times greater than existing antibodies called nirsevimab and clethrovimab, while also neutralizing a broader array of strains.

The findings align with pediatric wisdom that suggests medical professionals become more resilient to respiratory viruses as they gain experience. Dr. Trent Calcutt from Port Macquarie Base Hospital, Australia, noted, “After a decade of working with pediatric patients, I’ve seen a marked decline in serious respiratory illnesses in myself.”

Dr. Calcutt views the pediatrician-derived antibody’s potential as promising enough to justify further exploration in human clinical trials, stating, “Given the unusual nature of this intervention, it deserves serious consideration.”

Presently, two primary methods exist to safeguard infants from RSV: administering a maternal vaccine during pregnancy to afford protection post-birth and providing injections of nirsevimab or clethrovimab to neutralize the virus upon infection. However, these treatments are limited to specific RSV strains.

Interestingly, nirsevimab and clethrovimab were developed by screening the blood of adults who have dealt with RSV without being healthcare workers, identifying antibodies generated through natural infection. As of now, there are no approved vaccines or antibody treatments available for human metapneumovirus.

Topics:

  • Children /
  • Infectious Disease

Source: www.newscientist.com

6 Expert Tips from a Pediatrician to Foster a Healthy Relationship with Food in Your Child

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Parents Can Foster Healthy Eating Habits in Children

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Nancy Bostock, a pediatrician at Cambridgeshire and Peterborough NHS Foundation Trust, is deeply concerned about the conflicting messages regarding food that children and parents receive. With her expertise in children’s weight management and mental health, she has co-led the creation of innovative food strategies. For more information, visit Cambridge Children’s Hospital.

“I worry that parents may feel overwhelmed by advice from various sources, leading them to adopt practices that might not serve their children’s best interests,” Bostock explains. In her interview with New Scientist, she shares six straightforward, science-based strategies to help children cultivate a healthy relationship with food.

1. Emphasize the Social and Emotional Dimensions of Eating

Eating, parenting, and anxiety are intertwined. This can manifest early in life. Some families experience food insecurity shortly after the birth of a child, pressuring parents to breastfeed. While breastfeeding is undoubtedly beneficial, it is also crucial for the mother’s mental health. Common early-life challenges such as hypoglycemia and jaundice can induce parental guilt over inadequate nourishment.

This stress often leads parents to excessively monitor their children’s eating habits, overshadowing the fundamental relationship between children and food. Remember, most children will eat when hungry and drink when thirsty.

Many parents fret about whether their children drink enough water. However, as long as your child is thriving, there’s no need to constantly check their hydration levels. Trust your child’s instincts.

Additionally, consider the social dynamics of family meals. Reflect on mealtime experiences: do you all eat together? Are meals enjoyable and relaxed? Foster a positive and communal atmosphere surrounding food.

2. Avoid Saying, “I Can’t Eat the Dessert Until I Finish My Dinner.”

Allowing children to regulate their own appetite fosters healthier eating habits as they grow. Minimize parental interference: promote that food is a source of nourishment and energy, and let your child understand their bodily needs.

Statements like “you can’t have dessert until finishing dinner” can lead to unhealthy binge eating. If dessert is always sweet and rich, children might favor less nutritious foods over time, sending a negative message about enjoying food. Instead, serve dinner followed by fruit if desired.

3. Refrain from Imposing Unnecessary Dietary Restrictions

Amidst abundant dietary advice, parents often seek guidance from nutritionists or behavioral specialists to manage children’s eating habits. However, many recommendations to restrict particular foods lack medical foundation. For instance, enforcing a gluten-free diet without celiac disease could have negative effects, including fiber loss and nutrient deficiencies.

Moreover, outright banning certain foods can create a perception of them being “unsafe.” Research suggests that a healthier approach is to prioritize the intake of nutrient-rich foods—fiber, fruits, vegetables, and whole grains—over eliminating food groups.

4. Prevent Children from Using Food for Manipulation

Parents often worry about their children’s eating habits or how their behavior might change if they don’t eat enough. Kids quickly pick up on their parents’ concerns and may manipulate situations with food. Phrases like “If I don’t have ice cream right now, I’ll be sad” can escalate the situation and, if parents give in, this only reinforces bad behavior. Instead, communicate that eating is for energy and health, not a bargaining tool. Offer choices without pressure, like fruit or yogurt if they don’t want the main meal.

5. Recognize That Likes and Dislikes Are Normal

It’s normal for children to become picky eaters as they develop. Research shows that a significant percentage of preschoolers exhibit selective eating behaviors. This phase helps children differentiate safe from unsafe foods. Rather than imposing restrictions, present new foods without pressure; studies suggest children typically need about 15 positive exposures to a new food before accepting it.

While it’s essential to avoid foods known to cause allergies, continued exposure to a range of foods is crucial for health, environmental sustainability, and diverse life experiences. Offer variety and understand that tolerance can precede acceptance.

6. Reflect on Your Own Eating Behaviors

Children mirror their parents’ attitudes and beliefs about food. It’s vital to model healthy perspectives. If you express negativity about your body or weight, children may internalize similar thoughts. Evidence shows kids often adopt their parents’ biases. Hence, the best way to nurture a positive relationship with food and body image in your child is to cultivate one in yourself.

As narrated by Helen Thomson

If your child’s diet is excessively restricted, or if they are not growing or gaining weight appropriately, please consult a healthcare professional.

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Source: www.newscientist.com