Many Individuals Carrying the High Cholesterol Gene Are Unaware, Study Reveals

Experts caution that you might be unintentionally increasing your risk for a hereditary condition that leads to elevated cholesterol levels, according to new findings. Familial hypercholesterolemia can remain undetected for generations, thereby heightening the risk of heart attack and stroke for affected individuals, as reported.

This condition impacts approximately 1 in 200-250 individuals globally and leads to elevated levels of low-density lipoprotein (LDL) cholesterol from birth. LDL is often referred to as “bad” cholesterol because it contributes to arterial plaque buildup. However, researchers indicate it frequently goes unnoticed by standard testing methods.

To assess how many cases of familial hypercholesterolemia remain undiagnosed, Mayo Clinic researchers conducted an analysis involving 84,000 individuals. They specifically examined exome sequencing data, a genetic test that evaluates the segments of DNA that code for proteins.

Among these participants, 419 were identified as being at risk for familial hypercholesterolemia, with 90% unaware of their condition.

Adding to the concern, one in five of these individuals had already developed coronary artery disease.

The findings suggested that these patients would likely not be identified through standard genetic testing methods.

At present, genetic testing in the United States is only conducted on those exhibiting sufficiently high cholesterol levels or possessing a recorded family history of such levels—an issue identified by Mayo Clinic researchers as a “blind spot” in national guidelines. Seventy-five percent of those diagnosed in this study would not have qualified under these criteria.

The study emphasizes that regular screenings can reveal symptoms and potentially save lives, though other researchers highlight that this is not straightforward.

“The challenge is that screening everyone who would benefit from a genetic test can be prohibitively expensive, necessitating certain thresholds,” remarked cardiometabolic medicine researcher Professor Naveed Sattar in an interview with BBC Science Focus.

“Broadening screening efforts for familial hypercholesterolemia will only be feasible if testing costs decrease significantly. Nonetheless, we still need more individuals to undergo blood tests and seek genetic evaluations.”

Most individuals with familial hypercholesterolemia exhibit no symptoms. However, Sattar points out that yellowish deposits beneath the skin or, if under 45, a grayish-white ring around the eye’s cornea can indicate the condition.

“Yet, many people have no visible signs. If there is a strong family history of early heart attacks—especially if a first-degree relative experienced one before age 50—you should consider getting a lipid test earlier than the typical midlife screening.”

The findings were published in the journal Circulation: Genomic Medicine and Precision Medicine.

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Source: www.sciencefocus.com

Orca mother grieving loss of newborn now carrying second calf’s body

overview

  • An orca that carried around a dead calf for several days in 2018 appears to be repeating the same behavior with a newly dead calf.
  • Scientists believe the killer whales are likely expressing sadness.
  • Killer whales are part of an endangered subpopulation known as southern killer whales.

Nearly six years ago, a mother orca attracted international attention when she carried a dead calf for 17 days straight. Sadly, the whale now appears to be repeating what researchers say is an expression of grief over another deceased newborn.

The mother whale, also known as J35 or Tahlequah, was first spotted with her new calf on December 20th. But on Wednesday, researchers with the National Oceanic and Atmospheric Administration photographed a whale with a dead calf on its head off the coast of West Seattle.

“We can confirm that J31 lost the calf and was pushing it around on its head,” Brad Hanson, a researcher at NOAA’s Northwest Fisheries Science Center, said in a press conference Thursday.

He said that when the calf is about to sink, “she seems to do a high arch dive to retrieve the calf, but at that point you can’t really tell if she’s pushing or grabbing the calf.” added. ”

Scientists said they believe Tahlequah likely carried the dead calf as an expression of grief. Whales have a similar wiring structure to humans and other large, long-lived social mammals, Joe Gaydos, scientific director of the Sea Dog Society, an ocean research organization, said at a press conference.

“We have the same neurotransmitters as they do. We have the same hormones as they do. Shouldn’t we have the same emotions that they have? We are a market cornered by emotions.” So I think it’s fair to say she’s sad or grieving,” Gaydos said, adding that similar behavior has been observed in dolphins and non-human primates. added.

Tahlequah, also known as J35, and a dead calf.
NOAA

J35 is part of an endangered subpopulation of whales known as southern killer whales. The death of Tahlequah’s calf and the recent birth of another killer whale left the group at just 73 individuals.

Over the years, Tahlequah has had two surviving calves, both male, one born in 2020.

Southerners have been given tracking numbers by the Center for Whale Research and are closely watched by researchers, photographers and whale watchers, especially if they are near Puget Sound communities like Seattle.

Scientists have been following the story of the dead calf for weeks. Hanson said NOAA researchers discovered the female calf themselves on Dec. 23 after a citizen scientist first noticed the female calf, called J61. They were concerned about the calf’s health at the time because it appeared to be struggling and surfacing unusually, he said.

It is not uncommon for orca pups to die shortly after birth. Michael Weiss, director of research at the Center for Whale Research, said the first year of life is the biggest hurdle to survival.

Approximately 70% to 80% of calves that researchers can record and give identification numbers survive the first few years.

“We don’t know exactly what the survival rate is, probably because so many calves are born and die before they are photographed or recorded,” Weiss says. “Probably 50 percent of calves born will survive the first year.”

NOAA researchers said they are now concerned about Tahlequah’s own health because pushing his calves creates a lot of resistance in the water and requires a lot of energy.

“One thing she probably doesn’t have time for is feeding,” Hanson said. “We are concerned that she is expending so much energy caring for her lost calf.”

This is a typical calving season for southern whales. Hanson said researchers were encouraged by the birth of another killer whale, called J62. The orca was first spotted by observers on Dec. 30 and confirmed by the Cetacean Research Center on New Year’s Day.

“It appears to be very robust,” Hanson said.

Southern killer whales have been the subject of conservation efforts for decades. They are protected under the Marine Mammal Protection Act and were listed as endangered in 2005.

Whales typically spend several months each year along the Puget Sound coastline in Washington state. They live in three pods called J, K, and L, and have evolved to eat primarily fish, including the prized Chinook salmon.

In the early 1960s, many of Minami’s killer whales were killed or captured, and some of the surviving killer whales were put on display in marine parks. As of 1974, surveys showed that only 71 individuals remained in the wild. The population has since fluctuated, reaching a high of 95 people in 1995, but has declined since then.

The main reasons why whales are struggling are a decline in the quality and quantity of their prey and pollution from industrial chemicals such as polychlorinated biphenyls (PCBs) that contaminate their prey and accumulate in their bodies. Additionally, ship noise can disturb whales and prevent communication.

Research shows that unless more aggressive action is taken, the southern population is on a path to extinction. Already, Washington state and federal agencies have invested more than $1 billion in programs to reduce threats to whales. But the essential point still remains. Southerners simply don’t have enough food.

Major rivers that were once rich in salmon, including the lower Snake River, have been dammed, limiting access to and survival of salmon.

“We’re not doing enough on chinook recovery and salmon recovery,” Gaydos said.

For struggling southerners, the loss of a female calf is a devastating blow not only to the mother but to the trajectory of the subspecies as a whole.

“The real limit is the number of females that reach reproductive age and their ability to actually raise calves successfully. So we would like to see more females in the population.” Weiss said.

Source: www.nbcnews.com

Orca successfully delivers healthy calf after carrying deceased newborn over 1,000 miles

The orca who captured hearts worldwide in 2018 by refusing to let go of her deceased calf has now welcomed her second baby in the last four years.

The Whale Research Center has confirmed that their team has started monitoring the new baby girl on Monday, giving her the alphanumeric name “J61.” They are closely monitoring and observing the calf’s well-being.

The mother, known as Tahlequah with the designation number J35, is an experienced mother. The center is concerned about the health of both J61 and her mother during this critical period.

The early years are especially risky for newborn calves, with high mortality rates in the first year. The Center for Whale Research expressed their hope that J35 will be able to keep J61 safe through this challenging time.

Tahlequah made headlines globally in 2018 when she carried her deceased calf for 17 days, moving people around the world with her display of grief. Her actions prompted Washington State Governor Jay Inslee to establish the Southern Resident Killer Whale Task Force for conservation efforts.

J61 is Tahlequah’s third surviving calf, following J47 or “Notch” born in 2010 and J57 or “Phoenix” born in 2020. They belong to the J pod of killer whales, residing in the coastal waters between Washington state and Vancouver Island, British Columbia.

The J-Pod is one of three pods of Southern Resident killer whales, totaling about 73 orcas across the pods. Conservation groups are working to protect and restore the declining population of these majestic creatures.

Threats to killer whales include entanglement in fishing nets, food scarcity, human interference, and environmental pollution. The declining population highlights the urgent need for conservation efforts to protect these endangered animals.

Contaminants in the water pose a significant threat to orcas, with industrial chemicals accumulating in the food chain and affecting the health of the whales. Female southern whales and their offspring are particularly vulnerable to these pollutants.

NOAA’s 2022 pod health assessment raises concerns about the impact of contaminants on the Southern Resident killer whale population, emphasizing the need for immediate action to protect these magnificent creatures.

Source: www.nbcnews.com

Las Vegas sees surge in mosquitoes carrying West Nile virus

summary

  • A record number of mosquitoes in and around Las Vegas are testing positive for the West Nile virus as mosquito populations across the region soar.
  • Local health officials are urging residents to take precautions to avoid being stung.
  • The situation in Las Vegas is a case study as climate change expands the reach of vector-borne diseases.

Record numbers of mosquitoes are carrying the West Nile virus in and around Las Vegas, prompting local health officials to issue a public warning. Take precautions To avoid getting bitten.

West Nile virus causes fever, headache, vomiting and diarrhea and is fatal in about 1 in 150 cases. There is no vaccine or medicine to treat or prevent the mosquito-borne disease.

In recent weeks, 169 of more than 24,000 mosquito swarms tested for West Nile virus in 25 Southern Nevada ZIP codes tested positive, meaning at least one mosquito in the swarm was carrying the virus. The number of mosquitoes and positive swarms recorded this early in the season broke the regional records for both indicators set in 2019.

“The mosquito population is huge and we've already seen significant numbers of mosquitoes carrying the West Nile virus,” said Vivek Raman, environmental health inspector for the Southern Nevada Health Department.

Health officials also identified six swimming pools in the Las Vegas area where people had tested positive for the St. Louis encephalitis virus, a mosquito-borne disease that causes potentially fatal inflammation of the brain.

For decades, climate scientists and public health officials have warned that climate change could increase the range of various infectious diseases, particularly those transmitted by mosquitoes. The Las Vegas mosquito surge and regional increase in West Nile virus outbreaks provide an important case study in how climate affects human health.

Climate change will increase the global average temperature and precipitation, creating ideal conditions for mosquitoes, who breed in still, warm water. It will also lengthen the warm season, lengthening the mosquito season. These changes will Human exposure risk Even in places where no cases have been recorded before, there is an increased risk of contracting diseases such as West Nile virus.

The first case of West Nile virus was recorded in Las Vegas in 2004, five years after the first case in the United States was recorded in New York City in 1999. The most recent West Nile virus outbreak in Las Vegas was five years ago, when 43 people were infected, and area health officials fear the situation could get even worse this summer.

Spring weather is coming to Nevada and much of the Southwest. It gets warmer Summer heat waves have become more intense in recent decades. In Las Vegas, the average spring temperature is 6.2 degree increase since 1970This month, the city has already A week of record-breaking heatwave.

Rising temperatures in Southern Nevada are creating favorable conditions for mosquitoes, said Nishay Mishra, an assistant professor of epidemiology at Columbia University. Additionally, the state's ongoing drought has lowered groundwater levels throughout the Colorado River basin, including Lake Mead, which could unexpectedly benefit the insects.

“Mosquitoes typically breed in places that are moist and hot,” Mishra says, “but in Nevada, when small bodies of water dry up, they create shallow water that's perfect for mosquito breeding.”

Las Vegas' mosquito surge has been enormous: Last year, local health officials counted 6,000 mosquitoes in traps set across Clark County between April and June. This year, the number is already over 24,000.

Most of these mosquitoes are Culex mosquitoes, which are the primary vectors of the West Nile virus. But another mosquito species that doesn't carry the virus, Aedes aegypti, has also become common in Las Vegas. It was first spotted in the area in 2017, and Raman attributes its spread in part to climate change.

Along with climate, human behavior also plays an important role in the spread of vector-borne diseases. Culex mosquitoes and Culex pipiens mosquitoes breed in many Las Vegas backyards, the former breeding in small pools of water such as those left by sprinklers, and the latter often breeding along the surface of untended swimming pools.

Raman said the best ways to prevent infection are to empty water containers outside, take care of swimming pools, wear protective clothing and use bug repellent to prevent insect bites.

Louise Ivers, professor of global health and social medicine at Harvard Medical School and director of the university's Global Health Institute, said situations like the one in Las Vegas will become more common as infectious diseases continue to rise around the world due to climate change.

“We expect to see new infections, the resurgence of old ones, and changes in the transmission patterns of existing ones like West Nile virus,” Ivers said. “We may no longer be able to do things that we were previously free to do without worrying as much about protection from vectors like mosquitoes and ticks.”

Source: www.nbcnews.com