Why Exercise Alone May Not Be Effective for Weight Loss: Key Insights

Benefits of Exercise vs Weight Loss

Exercise has numerous benefits, but weight loss might not be one of them.

Jeffrey Isaac Greenberg 5+/Alamy

Engaging in regular exercise is extremely beneficial for overall health; however, it may not effectively lead to weight loss. Recent studies provide compelling evidence explaining this phenomenon.

While individuals who up their exercise routine often burn extra calories, weight loss usually doesn’t align with the caloric expenditure expected. A meta-analysis of 14 trials indicates that our bodies often compensate by reducing energy expenditure in other activities.

Notably, the compensatory effects are pronounced when one combines reduced caloric intake with increased exercise, effectively negating the hoped-for weight loss benefits of physical activity. In simpler terms, while dietary restrictions can lead to weight loss, increasing exercise alongside dieting may yield minimal additional benefits.

“The real challenge here is that when you combine exercise and dieting, the body compensates more aggressively,” explains Herman Pontzer of Duke University, North Carolina. “Exercise is still beneficial, but weight loss isn’t guaranteed.”

In his research on the Hadza hunter-gatherers of Tanzania, Pontzer found that despite their high activity levels, they did not expend more energy than sedentary individuals. This led him to propose, back in 2015, that our bodies may have evolved to conserve energy through reduced expenditure when faced with increased physical activity.

Although some studies support this compensation theory, not all experts agree. Pontzer and fellow researcher Eric Trexler at Duke have examined existing studies that were designed for other purposes, ensuring their analysis was unbiased. They analyzed 14 trials involving around 450 participants—small due to the rigorous methods needed to monitor total energy expenditure.

Their findings revealed an average energy expenditure increase of only one-third of expectations based on increased physical activity levels. For instance, if a person’s workout routine burns an additional 200 calories daily, these trials reported an overall increase of only about 60 kilocalories.

Interestingly, the results varied significantly. Those who maintained their caloric intake saw about half of the expected increase in total energy expenditure, while individuals who increased their physical activity while reducing their caloric intake often did not observe any significant changes. “They’re exercising 200 calories a day but seeing no tangible results,” Pontzer noted.

The type of exercise also plays a crucial role; compensation predominantly occurs during aerobic activities like running. In contrast, strength training appears to result in greater-than-expected energy expenditure. For example, individuals who burn an extra 200 calories from weightlifting tend to increase their total energy expenditure by approximately 250 calories per day.

However, Pontzer advises caution in interpreting these findings, as energy expenditure measurement during weight training can be challenging. He hypothesizes that weightlifters may deplete energy while repairing and building muscle tissue.

Initially, Pontzer believed the type of exercise might be negligible, but he now finds the insights exciting as they reveal unrecognized aspects of energy compensation. Despite the gains in muscle, weightlifting participants exhibited minimal fat loss, indicating it may not be a practical approach for weight loss.

So, why does an increase in aerobic exercise not lead to expected increases in energy expenditure? This analysis suggests that the body compensates by reallocating energy expenditures across various systems. For instance, the resting metabolic rate, particularly during sleep, can decrease with increased aerobic activity.

“Our body adjusts how different organ systems function post-exercise,” Pontzer says. “Understanding these changes could provide insights into how exercise benefits different individuals unequally.”

While Pontzer’s findings provide support for energy compensation, skeptics remain. Researcher Dylan Thompson from the University of Bath emphasizes the results of a meta-analysis suggesting aerobic exercise does not significantly affect resting metabolic rates.

Additionally, there might be critical research limitations, as pointed out by Javier Gonzalez, also at the University of Bath. For example, additional exercise might replace other daily activities like gardening, which could account for the lack of increased energy expenditure.

Nevertheless, Pontzer asserts that some studies effectively rule out this possibility, as compensation effects have also been documented in animal studies, corroborating human findings. Nonetheless, Thompson and Gonzalez argue for the necessity of more rigorous studies. “We require meticulously designed randomized controlled trials involving humans,” Thompson concludes.

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Source: www.newscientist.com

Localized Dust Storms on Mars May Lead to Significant Water Loss, New Study Reveals

Evidence suggests that Mars once hosted significant amounts of water. Past studies indicate that the majority of atmospheric water loss occurs during the Martian southern summer. During this season, warm and dusty conditions allow water vapor to ascend to high altitudes, where it escapes into space without condensing. A groundbreaking study has unveiled a previously unidentified pathway for water loss, observed for the first time in the Martian northern summer. This research highlights how a localized, short-lived sandstorm in Mars Year 37 (August 2023) caused a surge in water vapor.



Close-up color image of a small dust storm on Mars, captured by ESA’s Mars Express’ HRSC instrument in April 2018. Image credit: ESA / DLR / FU Berlin / CC BY-SA 3.0 IGO.

Dr. Adrian Brines, a researcher at the Andalusian Institute of Astronomy and the University of Tokyo, stated, “Our findings reveal the impact of this type of storm on Earth’s climate evolution and open new avenues for understanding how Mars has lost water over time.”

While dust storms have long been recognized as significant contributors to water escape on Mars, previous discussions primarily focused on large-scale dust events occurring on a planetary scale.

In this study, Dr. Brines and colleagues demonstrated that smaller, localized storms can significantly enhance the transport of water vapor to high altitudes, where it is lost to space more readily.

Prior research concentrated on the warm and dynamic summers of the Southern Hemisphere, as this is the primary period for water loss on Mars.

The recent study detected an unusual spike in water vapor in Mars’ middle atmosphere, attributed to a localized dust storm during the northern hemisphere summer of Martian year 37.



Diagram demonstrating the atmospheric response to localized sandstorms in the Northern Hemisphere during summer. High dust concentrations significantly enhance solar radiation absorption, promoting atmospheric warming, especially in the middle atmosphere. This increased circulation enhances the vertical transport of water vapor, facilitating its injection at high altitudes and increasing hydrogen efflux from the exobase. Image credit: Brines et al., doi: 10.1038/s43247-025-03157-5.

This surge in water vapor was unprecedented, reaching levels up to 10 times higher than normal—an occurrence not predicted by existing climate models or observed in previous Martian epochs.

Following this event, the amount of hydrogen in Mars’ exobase—where the atmosphere transitions into space—also rose significantly, increasing by 2.5 times compared to the previous year.

Understanding how much water Mars has lost over time hinges on measuring the hydrogen that escapes into space, as this element is produced when water decomposes in the atmosphere.

Dr. Shohei Aoki, a researcher at the University of Tokyo and Tohoku University, noted, “These results provide a crucial piece to the incomplete puzzle of how Mars has persistently lost water over billions of years, demonstrating that brief but intense episodes can significantly influence the evolution of Mars’ climate.”

Discover more about these findings in the featured study, published this week in Communication: Earth and Environment.

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A. Brines et al. 2026. Unseasonal water escape during summer in Mars’ northern hemisphere caused by localized strong sandstorms. Communication: Earth and Environment 7, 55; doi: 10.1038/s43247-025-03157-5

Source: www.sci.news

Revolutionary Weight Loss Drug Launch: The Ultimate Solution is Here!

Ozempic is a well-known name, primarily approved for diabetes treatment in the UK and US, yet it is commonly prescribed ‘off-label’ for weight loss. This medication has essentially become synonymous with a groundbreaking new category of weight loss drugs.

Injectable medications like Ozempic, Wegovy, Mounjaro, Zepbound, Rybelsus, and Saxenda can facilitate significant weight loss, approaching 20% of a person’s body weight in certain individuals.

Now, the next generation of weight loss solutions has arrived, and they are available in pill form.

The debut of these tablets occurred in the United States, with Novo Nordisk (the producer of Ozempic) launching Wegovy tablets on January 5, 2026. Their quick rise in popularity resulted in over 18,000 new prescriptions issued in the first week alone.

But Wegovy won’t stand alone for long. Eli Lilly’s competing drug, orforglipron, is projected to gain FDA approval this spring, and several alternatives are in development.

(Currently, these tablets are not available in the UK; however, UK policies are anticipated to follow the FDA’s example.)

The mechanism of these tablets mirrors that of injectables. The active compounds, known as “incretins” (like Wegovy’s semaglutide and Mounjaro’s tirzepatide), deceive the body into feeling full by imitating natural satiety hormones.

As digestion slows down, you naturally consume less, leading to weight loss. Don’t let hunger hinder your journey to success.

Now available in pill form, this medication promises similar life-altering effects and protection against obesity-related illnesses, all while being more affordable than ever.

Is it too good to be true? Experts caution that while the pill presents notable risks, it also brings substantial benefits.

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Can Weight Loss Drugs Transform the Landscape of Treatment?

These tablets could signify a new chapter in the management of obesity, providing broader access to life-altering healthcare.

“Not everyone prefers injectable medications,” states Dr. Simon Cork, a senior lecturer in appetite and weight regulation at Anglia Ruskin University in the UK. “Injections can be uncomfortable for many patients, making oral administration a more appealing option.”

Besides comfort, switching from injections to pills could massively reduce monthly costs. Those using weight loss drugs today often spend hundreds of dollars each month on injections.

Weight loss pills can be stored at room temperature in standard pill blister packs, making them more accessible – Credit: Getty Images

Thanks to the absence of needles and refrigeration needs, these pills can be produced and distributed at lower costs, providing weight loss solutions to millions who previously faced exorbitant prices.

“Overall, these pills are expected to be significantly more affordable than current injection therapies,” says Cork.

This trend is already visible in the US, where Wegovy pens are priced at $349 (approximately £250) per month, whereas Wegovy tablets retail for $149 (around £110).

In the UK, nearly 95% of incretin users incur high private fees. According to Professor Giles Yeo from the University of Cambridge, the NHS often cannot prescribe these expensive medications to all patients who need them.

“Patients may need to maintain these drugs for extended periods, which exacerbates the financial barrier, particularly for those from disadvantaged backgrounds most susceptible to obesity,” Cork noted. “I hope that these oral medications will democratize access.”

Addressing Long-Term Challenges

However, these drugs may not be the most effective options, even as their availability increases.

Incretins tend to offer lower efficacy in pill form. Injectable Wegovy has demonstrated a capacity to help users lose 15% of body weight after 68 weeks, while Wegovy tablets showed only 13.6% weight loss across 64 weeks.

The efficacy of pills may not match that of modern injected solutions. Retatortide, still in development, has shown results of 24% body weight reduction in just 48 weeks.

Administering these drugs through pills poses inherent challenges. Oral medications must traverse the stomach and liver before entering circulation, resulting in the manufacturer needing to increase the amount of active ingredient to achieve desired outcomes.

Consequently, weight loss results from pills may not be as rapid as from injections. Nevertheless, a significant complaint regarding injections—that discontinuing them often leads to weight regain—may see improvement.

A 2022 study revealed that participants who halted Wegovy injections regained up to two-thirds of their lost weight within one year.

The emergence of the pill could provide a solution. A recent study, the Eli Lilly ATTAIN-MAINTAIN Trial, showed that Orforglipron tablets helped participants stabilize their weight after stopping injectable therapy.

“Many might rely on these medications to maintain weight loss,” Yeo suggests.

Cork adds, “Injectables can be utilized for optimal weight loss, and pills can help maintain this weight affordably.”

Most incretins mimic the natural satiety hormone GLP-1, but new treatments are targeting multiple hormones for enhanced effectiveness – Credit: Getty Images

The Risks and Concerns of the Pill Revolution

While these drugs possess the potential to catalyze significant positive change, their widespread availability also raises risks for vulnerable populations.

“The major danger is these drugs entering the wrong hands,” warns Yeo. “Since there’s no weight limit to how these drugs might impact individuals, a 300-pound person aiming to lose 50 pounds could utilize it as well as a 16-year-old girl weighing 75 pounds.”

“Pills can easily be trafficked, making them accessible to anyone. It’s essential to establish strict regulations around their distribution,” he urges.

Cork shares concerns over side effects. Incretins can provoke various symptoms, including nausea, vomiting, constipation, and diarrhea. Clinical trials found that three-quarters of participants experienced digestive issues.

Moreover, there are rare but serious risks such as pancreatitis, gallstones, and gastroparesis. Additionally, interactions with other medications, including contraceptives, could affect their efficacy.

“The risk of pancreatitis is low, around 1%,” Cork notes. “But with millions potentially using these drugs, this risk becomes concerning without appropriate oversight.”

Though these warnings are sobering, they remain speculative. The actual impact of these drugs is still uncertain.

“2026 is poised to be a crucial year in understanding the efficacy, prevalence, and applications of these medications,” Yeo concludes. “Time will tell how things unfold.”

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Source: www.sciencefocus.com

Chernobyl Cooling System Power Loss: Low Meltdown Risk Explained

Chernobyl Nuclear Power Plant

The Chernobyl nuclear power plant has endured multiple attacks following Russia’s invasion of Ukraine.

AFP

A recent power outage at the Chernobyl nuclear power plant in Ukraine has disrupted the spent fuel cooling system, increasing the risk of overheating and the potential release of harmful radiation. Fortunately, the stored fuel is aged and expected to remain safe until power is restored.

The International Atomic Energy Agency (IAEA) has confirmed that Russian military actions have targeted multiple electrical substations in Ukraine, leading to the current power outage at Chernobyl. “The IAEA is closely monitoring these developments to ensure nuclear safety,” stated IAEA Director-General Rafael Grossi in a recent update on X.

Spent nuclear fuel continues to emit radiation and generate heat for years after being removed from a reactor. Without proper cooling, the fuel can melt, resulting in dangerous radiation levels. Currently, Chernobyl’s old fuel is stored in large cooling ponds that are regularly replenished with cold water to maintain safe temperatures.

However, the IAEA reported that the site lacks a power supply, which halts cooling efforts, leading to increased water temperatures and evaporation rates.

“Once the fuel is out of the reactor, it remains hot due to the production of fission products and radiative materials. It’s essential to manage this heat effectively, or it may eventually lead to a meltdown,” explained Paul Cosgrove from Cambridge University. More information can be found on his profile here.


Fortunately, the risk associated with the stored fuel at Chernobyl is lower today compared to 2022 when similar power outages occurred, as the fuel has already cooled significantly over the years. New Scientist reported this decrease in risk.

“Power loss at nuclear facilities is concerning, but the perceived nuclear risks often far exceed the actual risks associated with comparable incidents,” noted Ian Farnan from Cambridge University. More details about his work can be found here.

The Chernobyl disaster involved a reactor explosion in 1986, with reactors 2, 1, and 3 being shut down in 1991, 1996, and 2000, respectively.

While details of the storage pool containing Chernobyl’s remaining fuel are classified, Cosgrove indicated that evaluations conducted in 2022 found minimal risk of overheating during power outages. “This fuel has been stored safely for over 20 years, leading to significant energy dissipation,” he emphasized.

Electricity delivery to Chernobyl, as well as much of Ukraine, has fluctuated since the commencement of the full-scale Russian invasion. Recently, heightened attacks on Ukraine’s infrastructure by Russian forces have exacerbated the situation.

This power outage at Chernobyl represents yet another instance of Russian actions undermining nuclear safety, including the temporary occupation of Chernobyl, preventing necessary maintenance, the seizure of the Zaporizhzhia nuclear power plant, and last February’s drone attack on the containment structures above the ruins of Chernobyl’s reactor 4.

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Source: www.newscientist.com

Red Tattoo Ink Linked to Hair Loss and Sweating Issues: A Cautionary Tale

Inflamed Areas of a Man’s Tattoo

University Centre for General Dermatology and Oncodermatology, Wrocław Medical University

A Polish man experienced a severe allergic reaction to the red ink used in his tattoo, resulting in hair loss, cessation of sweat production, and the development of vitiligo. This alarming case highlights potential adverse effects of certain modern tattoo inks on the immune system.

Tattooing is a time-honored practice that traditionally utilized black soot-based inks and manual techniques. Today, electric tattoo machines are employed to rapidly apply colorful synthetic inks across larger skin areas.

Many dyes found in colored tattoo inks were originally formulated for use in printer inks and automotive paints, not for human application. Reports of allergic reactions to colorful tattoo inks have surged in recent years, particularly among individuals with existing immune issues, such as eczema, asthma, and celiac disease. According to research, around 6% of people report allergic reactions that persist for more than four months, particularly with red ink.

The Polish man’s symptoms began four months post-tattoo application on his forearm. Initially, itched intensely, followed by the emergence of a widespread red rash. Over time, he developed hair loss, yellowing nails, swollen lymph nodes, and an inability to sweat. After two years, he also noticed large patches of vitiligo.

Despite consultations with several specialists, including dermatologists and allergists, the underlying issue remained undiagnosed. It wasn’t until the red ink decorations of his tattoo became visibly inflamed that suspicion arose. A biopsy of a swollen lymph node revealed traces of red ink had migrated from the tattoo site.

Due to limited treatment options, the man underwent eight surgeries to eliminate the problematic red ink and apply skin grafts. Post-treatment, while his hair has regrown and vitiligo has stabilized, he still suffers from permanent dysfunction of his sweat glands, presenting a risk of heat exhaustion and necessitating his resignation from military service, as he must frequently spray himself with water.

Despite attempts, dermatologists at Wrocław Medical University could not obtain a sample of the red ink for analysis. However, past studies have identified synthetic organic dyes, particularly azo dyes, as agents responsible for allergic reactions in red tattoos.

The potential health risks associated with tattoo ink are linked to its chronic activation of the immune system. Most tattoo ink remains on the skin, but some can migrate to lymph nodes. Here, immune cells known as macrophages attempt to eliminate the ink but often fail due to its size. This failure leads to a cycle of immune activation, as macrophages transfer the ink to others, perpetuating the immune response. Dr. Sine Clemmensen of the University of Southern Denmark elaborates on this issue.

The Polish man also had Hashimoto’s disease, an autoimmune condition that may have heightened his sensitivity, resulting in the immune system mistakenly attacking his skin.

Emerging research suggests that even individuals without pre-existing immune conditions might face long-term risks related to tattoos. Clemmensen’s findings indicate that having any tattoo color could triple the risk of developing lymphoma, a cancer affecting the lymphatic system.

In January 2022, following another case similar to that of the Polish man, the European Union initiated measures to enhance tattoo safety by restricting chemicals commonly found in tattoo inks with azo dyes. However, legislation in other regions is still pending.

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Source: www.newscientist.com

2026: The Next Landmark Year for Breakthrough Weight Loss Medications

Travel Pix Pro/Getty Images

Many individuals set New Year’s resolutions to lose weight, particularly following the holiday festivities. Traditionally, this involved adopting a new diet, waking up early for workouts, and other habits that can be challenging to sustain. Consequently, it’s no surprise that numerous people abandon their goals within weeks.

Today, however, an alternative has emerged: weight loss medications. Instead of solely depending on lifestyle changes, individuals can benefit from regular doses of GLP-1 agonists or other therapeutic tablets (as highlighted on page 6). Health professionals still recommend integrating these medications with consistent physical activity for optimal results.

GLP-1 drugs are not only transforming our cyclical health regimens. Restaurants are now crafting menus specifically for Ozempic diners, featuring smaller portion sizes for customers who experience reduced appetite. Additionally, supermarkets have reported declines in sales due to decreased demand from those using these medications. Airlines are also considering the implications, as decreased average passenger weight could lower fuel expenses.

While it’s unclear how much these trends can be attributed to GLP-1 drugs—which are currently used by a minority—and the extent of their impact on brands reacting to this health trend, the statistics surrounding obesity are alarming. Approximately 1 billion individuals globally are affected by obesity, and the adoption of these medications is expected to rise. According to World Health Organization estimates, fewer than 10 percent of people will utilize GLP-1 drugs by 2030, yet this still represents a substantial demographic.


Restaurants are designing menus featuring reduced portions for Ozempic diners.

New advancements in medication are in development (refer to page 7), and the potential impacts could be even more significant. Beyond weight reduction, GLP-1 agonists have shown promise in treating various conditions, from addiction to eye diseases like cataracts.

While there remain numerous uncertainties regarding the long-term consequences, the results of discontinuation, and enhancing accessibility, the future appears bright. As we advance further into the 21st century, weight loss drugs are poised to play a crucial role in shaping health and wellness trends.

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Source: www.newscientist.com

Essential Science-Backed Metabolic Strategies for Effective Weight Loss

If you’ve struggled with weight loss, you may have attributed it to your metabolism. This elusive concept seems to make losing weight effortless for some, while for others, it feels like an uphill battle.

However, this perception misrepresents how the body truly functions, neglecting the critical elements of fat loss.

Metabolism encompasses more than just “the number of calories burned.” It’s a complex network of chemical reactions occurring in your cells and tissues that power everything you do.

Many individuals simplify it to a single statistic: calories burned at a specific moment.

Here, “metabolic rate” becomes relevant. It’s the standard metric for gauging how quickly your metabolism operates. Essentially, it’s the energy expended at rest, representing the minimal energy required to keep bodily functions active.

A common belief is that lean individuals possess a “fast” metabolism, burning more calories effortlessly. In fact, larger bodies often exhibit a “faster” metabolism.

The metabolic rate largely hinges on body size—greater tissue requires more energy for maintenance.

However, weight alone is a rudimentary gauge. Two individuals may weigh the same, but differences in fat-to-muscle ratios can significantly influence their metabolic rates.

Lean mass, particularly organs, plays a pivotal role in energy expenditure. The liver and brain alone contribute about half of the body’s resting energy requirements, with the kidneys accounting for nearly 20 percent.

Though skeletal muscle has a lower metabolic activity than organs (approximately 20 times less active per gram), its substantial mass contributes significantly to resting energy expenditure.

Since organ masses are consistent among individuals of similar size, muscle and fat primarily dictate metabolic variations.

This distinction also elucidates the differences between men and women. Men generally have a higher muscle mass and lower fat percentage, leading to a greater metabolic rate at the same weight.

Once body composition and gender are factored, metabolic rates prove to be surprisingly predictable, challenging the notion that some individuals have substantially “faster” metabolisms than others.

Deceleration Myth

Age-related hormonal changes often promote fat gain – Photo credit: Getty

There’s a common belief that metabolic rates decline with age. However, this perception may not hold, particularly for middle-aged individuals.

Taking body composition into account, metabolic rates typically remain stable until about age 65. The earlier drop is more related to shifts in muscle and fat than a mysterious “aging metabolism.”

Changes in hormonal balance, particularly during menopause, can impact metabolism.

Hormonal changes often promote fat gain while contributing to muscle loss, particularly around the abdomen, both of which can lower metabolic rates.

Additionally, reduced estrogen levels can affect thermogenesis, potentially slowing metabolism and leading to hot flashes.

After age 65, energy expenditure tends to diminish, not because of metabolic “aging,” but due to broader physical changes.

Muscle mass typically declines faster, lessening both muscle and organ metabolic activity, resulting in lower calorie burning.

The good news? Staying active, eating healthily, and preserving muscle mass can help mitigate muscle loss.

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Built-in Balance Adjustment Function

If metabolism is mostly predictable, can it be entirely fixed? Not quite. Depending on circumstances, your body can gradually adjust its calorie burn.

For instance, someone who is overweight naturally burns more calories due to increased tissue maintenance. Research suggests their bodies might slightly ramp up calorie burning to eliminate excess weight.

Conversely, underweight individuals may consume fewer calories than anticipated because their metabolic rates decrease further, becoming very conservative with energy usage.

How does this occur? Some studies propose that the body can intentionally waste energy by generating heat, a process known as adaptive (or conditional) thermogenesis.

This process involves specialized fat cells called brown fat and certain proteins in muscles and other tissues, which can “leak” more (or fewer) calories as heat instead of storing them.

This heat dissipation is subtle—not felt as sweat or fever—but is a behind-the-scenes adjustment that fine-tunes energy balance.

Brown fat, or adipose tissue, burns energy to regulate body temperature – Photo credit: Getty

Adaptive thermogenesis does not mean being confined to a fixed body weight. This explains why dieting can feel like swimming against the tide. When calorie intake is cut, the body often retaliates by slowing metabolism, making it harder to sustain progress.

This leads to a pressing question: Can you truly change your metabolism, and if so, what methods are effective?

There Is No Magic Menu

You may have encountered claims that certain foods, like caffeine, polyphenols from spicy foods, or chili pepper extract, “boost” metabolism and increase calorie burn through thermogenesis.

However, the actual calorie increases from these ingredients are minimal, detectable only for short periods—lasting mere minutes to hours.

Another suggestion is to increase protein intake to speed up metabolism.

The premise is that digesting and absorbing protein requires more energy than digesting carbohydrates and fats, potentially resulting in fewer overall calories gained. However, this difference in calorie burn is often negligible.

While increased protein can help maintain and build muscle—supporting a higher metabolic rate—muscle growth is not solely reliant on protein.

Muscle repair and growth are stimulated primarily through exercise, especially resistance training.

In fact, exercise and physical activity are key to enhancing caloric usage, increasing your metabolism.

Moreover, exercise generates additional metabolic benefits beyond just the calories burned during the activity. Post-exercise, metabolism recovers at an accelerated rate as muscles adapt to the workout’s demands.

This phenomenon is known as excess post-exercise oxygen consumption (EPOC), commonly recognized as the “afterburn” effect.

This temporary spike in fuel and calorie usage can last for several hours, even up to 48 hours, particularly after workouts focused on muscle repair and growth.

While it may not be the shortcut many seek, when targeting metabolism and fat loss, exercise—particularly strength-building workouts—remains a far more effective strategy.

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Source: www.sciencefocus.com

Projected Decline in Weight Loss Drug Prices by 2026: What You Need to Know

Massive demand for weight loss medications

Surge in demand for drugs like Wegovy, Victoza, and Ozempic leads to shortages

Michael Silk/Alamy

The blockbuster weight loss drug semaglutide, along with competitors, offers potential solutions to the global obesity crisis. However, access remains limited for many who could greatly benefit from these innovations, though changes are on the horizon.

Historically, weight loss drugs have been scarce; yet, by the end of 2024, manufacturers are expected to meet the skyrocketing demand. Nevertheless, treatments like semaglutide (marketed as Wegovy or Ozempic) continue to carry hefty price tags, often reaching thousands of dollars annually.

This pricing structures keeps these essential medications out of reach for the over 1 billion individuals affected by obesity globally. In the U.S., a mere 3 percent of the population utilizes weight-loss medications, with the numbers dipping below 1 percent in other countries, according to Morgan Stanley.

Looking ahead, 2026 promises significant developments, including the approval of orforglipron in multiple countries. This new medication mimics the GLP-1 hormone, known for its appetite-reducing properties. Unlike semaglutide, orforglipron, as a small molecule, offers tablet-based administration.

“Tablets are inexpensive to produce, simple to store, and easy to distribute,” explains Dr. Laura Heisler from the University of Aberdeen, UK. “In essence, the medication can reach a broader audience in need.”

In contrast, semaglutide is a larger molecule and a type of protein. Polymer drugs like these are generally challenging and costly to produce. They often require injections, complicating their supply and driving up costs. This has been a significant barrier to fulfilling the demand for GLP-1 drugs.

It’s important to note that there is a semaglutide version in pill form, Rybelsus, approved for type 2 diabetes. Novo Nordisk, the manufacturer, has also sought approval for a weight loss variant.

However, Rybelsus isn’t just any medication; it includes semaglutide alongside sulcaprosate sodium, which neutralizes stomach acid to facilitate absorption into the bloodstream. To maximize effectiveness, it must be taken at least 8 hours post-meal, with no food or drink for 30 minutes.

This complexity is part of the reason orforglipron has a lower production cost compared to semaglutide—it can be taken without the stringent requirements of medications like Rybelsus.

Furthermore, the introduction of orforglipron will foster competition among pharmaceutical companies. While Lilly, the producer of Orforglipron, has yet to disclose pricing, it has been shown to be less costly than other GLP-1 alternatives.

The sole drawback is that orforglipron appears less effective; those on the highest doses typically lose about 10% of body weight over 72 weeks, compared to 14% with semaglutide. Further research is needed to validate these findings.

Another critical development is the anticipated expiration of semaglutide patents in nations such as China, India, Brazil, Canada, and Turkey—home to a significant population. This could pave the way for generic versions to enter the market.

Although generics must meet the same standards as their branded counterparts, they often come at a fraction of the cost. “Once a drug loses patent protection, generic competition usually leads to price reductions of up to 90%,” states Jeremy Durant of Medicines UK, the association for generic drug manufacturers.

This shift may expand access to these crucial treatments. That said, the World Health Organization (WHO) recently advised that patients should also receive counseling about behavioral modifications and lifestyle changes to maximize the efficacy of medications. “Drugs alone won’t address the global obesity crisis,” says Francesca Ceretti of WHO.

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Source: www.newscientist.com

2026 Weight Loss Drug Set to Outperform Ozempic and Zepbound: What You Need to Know

Innovative Weight Loss Treatments

Achieving a Healthy Weight: A Future of Possibilities

Merch Hub/Shutterstock

Recent advancements in obesity treatments have introduced highly effective medications, with the prospect of even more potent experimental treatments set for testing in 2026.

“We are witnessing an ambitious new phase in obesity treatment that promises improved health outcomes for numerous patients,” states Laura Heisler from the University of Aberdeen, UK. “Obesity is linked to severe health complications, including cancer, heart disease, and type 2 diabetes. A modest 5% reduction in body weight can significantly decrease these health risks.”

The first major weight loss drug, semaglutide, was initially approved as a diabetes treatment in 2017 under the name Ozempic. In 2021, it received approval for weight management as Wegovy.

Semaglutide functions by imitating the natural hormone GLP-1, which binds to brain and pancreatic receptors, helping to curb appetite and slow gastric emptying. Alongside its weight loss benefits, semaglutide has demonstrated positive cardiovascular effects and potential in managing conditions like substance addiction. However, common side effects like nausea can lead to discontinuation of the drug.

In 2023, Tirzepatide, marketed as Mounjaro for diabetes, secured approval for weight loss under the name Zepbound. Enhancing semaglutide’s effectiveness, Tirzepatide operates by mimicking both GLP-1 and another hormone, GIP, which is involved in energy management. Like semaglutide, it has comparable side effects.

In clinical trials, semaglutide resulted in an average weight reduction of 14% over 72 weeks, while participants using tirzepatide achieved a 20% reduction. Notably, regaining lost weight is common once the medication is stopped.

Looking ahead, more dual-action and even triple-action medications are in development. A promising candidate for 2024 approval is Kaglisema, which merges semaglutide with Caglilintide, a drug that stimulates fullness through amylin mimicry.

In a trial with over 3,400 adults, those taking Kaglisema achieved a weight loss of 20% after 68 weeks, outperforming both semaglutide (15%) and Caglilintide alone (12%), indicating strong potential.

Additionally, a drug named amicretin is undergoing development. Similar to CagliSema, it mimics both GLP-1 and amylin, but uses a single molecule that binds to both receptor types.

In preliminary trials involving 125 participants, amicretin users experienced an average weight loss of 24% after 36 weeks, suggesting superior effectiveness compared to tirzepatide, although final-stage trials won’t commence until 2026.

Moreover, the “triple G” drug letartortide activates three hormones to facilitate fat release: GLP-1, GIP, and glucagon. In a study of 338 individuals, those on the highest dose experienced an average weight loss of 24% after 48 weeks. Results from late-stage trials will be crucial for assessing letartortide’s approval timeline, expected in late 2026 or beyond.

It’s important to note that weight loss results from various clinical studies aren’t directly comparable due to differences in participant criteria, study durations, and dosages. Moreover, average results can mask significant variability in individual responses to GLP-1 drugs; while some experience negligible effects, others see remarkable weight loss.

As many as 100 new weight-loss drugs are currently in development for 2026 and beyond as companies strive to capture a share of the lucrative market. These innovations often focus on diverse combinations of existing targets, such as GLP-1, GIP, glucagon, and amylin receptors, or explore new mechanisms entirely.

Research is also addressing adverse effects, such as the evidence indicating some weight loss from GLP-1 drugs may come from muscle rather than fat. For instance, a recent trial earlier this year combined semaglutide with bimagrumab, a muscle growth inhibitor, seeking to counterbalance these effects.

“The prospect of emergent, highly effective drugs with fewer side effects is indeed exciting,” says Heisler.

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This optimization enhances the SEO value by incorporating relevant keywords, improving clarity, and ensuring the content is structured effectively while maintaining existing HTML tags.

Source: www.newscientist.com

The World Faces the Loss of 3,000 Glaciers Annually

The flow of melted snow creates channels through a glacier cave at the Morteratsch Glacier in Switzerland.

Lander Van Tricht

Currently, approximately 1,000 glaciers are disappearing each year, and if nations fulfill their carbon emission reduction goals, this could escalate to 3,000 glaciers lost annually by 2040.

Over the past two decades, at least 4,000 glaciers have melted. Lander Van Tricht and researchers at ETH Zurich in Switzerland utilized climate models to forecast the fate of the globe’s 211,000 glaciers in the coming century under various global warming scenarios.

If current climate targets remain unchanged, the planet is predicted to warm by 2.7 degrees Celsius above pre-industrial levels this century. This projection implies that 79% of the world’s glaciers will vanish by 2100. Conversely, if humanity manages to limit climate change to 2 degrees Celsius, 63% of glaciers will disappear.

“While we are destined to lose many glaciers, we still have the potential to protect a significant number,” observes David Rounce, who conducted research at Carnegie Mellon University in Pittsburgh, Pennsylvania.

If countries fail to meet their emissions targets and global warming escalates to 4°C, a staggering 91% of glaciers will be lost.

The forecast for glacier melting is predicted to accelerate sea level rise this century by 25 centimeters. Additionally, it will diminish the summer snowmelt water supply that many regions depend on for irrigation. Approximately two billion individuals live in watersheds nourished by mountain snow and ice, with many residing near rivers originating from Himalayan glaciers.

Moreover, melting ice poses a higher risk of flooding caused by sudden water releases from glacial lakes. In a 2023 incident in India, flooding resulted in the deaths of 55 individuals.

Previous studies have indicated that even if warming is restricted to the Paris Agreement’s most ambitious goal of 1.5 degrees Celsius, half of all glaciers will still melt this century. The recent research suggests that up to 55% may be lost at this level of warming.

The study also outlines the annual glacier loss rate by region. This rate is expected to peak around the mid-century and then decline as smaller glaciers disappear, leaving behind larger ones, particularly in the North and South Poles.

“Large ice takes time to melt, so they will take longer to disappear,” Van Tricht explains.

According to current climate goals, western Canada and the continental United States are likely to lose nearly all their glaciers by 2100. This is a significant setback for tourism, as Montana’s Glacier National Park is expected to lose the majority of its glaciers, although some may endure as small glaciers or ice remnants, based on future studies from the U.S. Geological Survey.

Similarly, the Alps are projected to be largely devoid of glaciers. Local communities are already holding glacier funerals, chronicling the stories of global glacier losses at a dedicated website. In 2019, around 250 individuals, including professors from ETH Zurich involved in this research, trekked to the remnants of the Pizol glacier.

They gathered not only to bid farewell but also to convey to the public that “we are connected to the glacier,” stated Matthias Hass. “When they are gone, it will be a significant loss for us.”

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Source: www.newscientist.com

Significant Shifts in Oral Microbiome During Pregnancy Could Contribute to Tooth Loss

Maintaining good oral hygiene may be especially important during pregnancy

Chondros Eva Catalin/Getty Images

A popular saying suggests that “if you give birth to a child, your teeth will fall out.” While pregnancy is known to elevate the risk of dental issues, the underlying reasons remain somewhat unclear. Recent studies indicate that the oral microbiome alters during pregnancy, becoming less diverse and potentially more susceptible to inflammation.

Hormonal changes during pregnancy are often cited as the main culprits for the increased risk of conditions like periodontal disease and tooth decay. Moreover, there’s a widespread belief that the fetus extracts calcium from the mother’s teeth, a notion that lacks scientific backing.

Disruption of the oral microbiome, which comprises over 700 bacterial species, can lead to dental issues regardless of pregnancy status. However, Yoram Luzon and his team from Bar-Ilan University in Israel aimed to explore whether this typically stable ecosystem shifts during pregnancy. They collected saliva samples from 346 Israeli women across all three trimesters: 11-14 weeks, 24-28 weeks, and 32-38 weeks.

Their investigation revealed a decrease in species diversity in saliva samples starting from the transition between the first and second trimesters, continuing to decline throughout the pregnancy. A notable characteristic was the reduction in the number of species, with Akkermansia muciniphila, often hailed as a beneficial bacterium, declining alongside an increase in pro-inflammatory bacteria like Gammaproteobacteria and Synergystobacteria.

“While the oral microbiome is generally stable, we have noted a gradual decrease in its diversity over the years,” Louzoun observes. “Pregnancy accelerates this slow evolution, allowing changes that typically take years to manifest in just nine months.”

Despite being relatively minor overall, numerous factors may contribute to these changes. “Pregnancy involves a multitude of hormonal shifts and inflammation, leading to alterations in your microbiome,” explains Lindsay Edwards from King’s College London. “Dietary changes are frequent during pregnancy, and various factors such as nausea, medication cessation, and altered eating habits all play a role.”

The participants filled out questionnaires regarding their diets and health, allowing the researchers to identify similar yet distinct effects among different women. This included those who followed a gluten-free diet, took antibiotics, experienced stress, or were current or former smokers. “Many women quit smoking during pregnancy, but their prior smoking habits can impact their microbiome,” notes Dr. Luzon, emphasizing the potential long-term effects.

A parallel study found similar changes in the oral microbiomes of 154 pregnant women in Russia during their second and third trimesters.

Although pregnancy heightens the risk of dental complications, particularly in the early stages, Luzon does not definitively link oral microbiome changes to these issues. “We can’t conclude whether these microbiome alterations are beneficial or detrimental, but they are undoubtedly changing rapidly,” he states.

Conversely, Edwards suggests that shifts in microbial composition might be a contributing factor, highlighting that saliva tends to become more acidic during pregnancy, altering the types of bacteria present.

Valentina Biagioli and her colleagues from the University of Genoa in Italy assert that changes in the oral microbiome may correlate with variations in systemic hormone levels, as both systems potentially influence each other. “There exists a plausible biological link connecting the observed microbiome changes to prevalent dental issues during pregnancy, such as tooth loss,” she comments.

Disruption in the oral microbiome has been noted to relate to pregnancy complications. Consequently, establishing what constitutes an optimal microbiome during pregnancy could serve as a benchmark for monitoring pregnancy progression. “Once we establish the baseline oral microbiome of pregnancy, deviations can be detected,” Louzoun states.

Moreover, ongoing research aims to elucidate this microbiome’s role in the immune system, affecting both the health of the pregnant woman and her unborn child. “The microbiome is instrumental in shaping the immune system, fostering a reciprocal relationship,” Edwards explains.

In light of this, enhancing our understanding of how to sustain a healthy oral microbiome (e.g., via good dental hygiene and a balanced, nutritious diet) could yield significant benefits. “Microbiome changes may influence the inflammatory state of expectant parents and better prepare the child’s immune system, potentially affecting long-term health, allergies, infection susceptibility, and chronic inflammatory conditions,” cautions Edwards.

topic:

Source: www.newscientist.com

Y Chromosome Loss: A Possible Factor in Lung Cancer Progression and Outcomes

Insights into the impact of Y chromosome loss on lung cancer treatment outcomes may guide therapeutic choices.

Dakuku/Getty Images

Research indicates that men diagnosed with the predominant type of lung cancer are more likely to lose the Y chromosome in their cells. This phenomenon has both pros and cons; while it can prevent the immune system from combating tumors, it also enhances the effectiveness of standard anti-cancer therapies.

As men grow older, their cells frequently undergo mutations, leading to the loss of the Y chromosome. In immune cells, this loss is believed to correlate with heart disease and decreased life expectancy. Additionally, there is growing evidence that cancer cells that lose the Y chromosome may influence symptom progression, with bladder cancer being the most thoroughly researched case.

The loss of the Y chromosome is a binary occurrence—it either happens or it doesn’t. However, the health implications seem to depend significantly on the proportion of specific cells that lack the Y chromosome.

The recent study initiated by Dawn DeMeo and her team at Brigham and Women’s Hospital in Boston, Massachusetts, investigated how Y-chromosome genes are expressed in a publicly available dataset of lung adenocarcinoma samples. Lung adenocarcinoma, the most common form of lung cancer, originates from the mucus-producing cells lining the airways. Enhanced understanding of the relationship between Y loss and various health issues has motivated researchers to delve deeper into gene expression studies, according to DeMeo.

The team discovered that cancer cells, in contrast to healthy lung and immune cells, often lack the Y chromosome. This occurrence is independent of whether the tissue donor is a smoker—despite smoking being linked to lung cancer and Y chromosome loss.

The loss of Y chromosomes appears to accumulate over time. “Certain groups demonstrate a higher rate of Y chromosome loss across a greater number of cells, and we observe significant Y chromosome loss in a large fraction of tumors,” stated John Quackenbush from Harvard University.

To comprehend the reasons behind this accumulation, researchers examined other genetic alterations in Y-negative cells. They found that the loss of a common set of antigens produced by cancer cells correlates with diminished expression levels. These antigens usually notify immune T cells that cancer cells are abnormal and should be targeted. The decreased expression allows Y-negative cancer cells to proliferate unchecked.

“This implies that as tumor cells lose their Y chromosome, they become increasingly adept at evading immune surveillance, suggesting a selection of tumor cells that escape immune detection,” Quackenbush explained. T cell counts were consistently lower in samples with Y loss compared to those retaining the Y chromosome.

Positive findings emerged when researchers analyzed data from 832 lung adenocarcinoma patients treated with the immune checkpoint inhibitor pembrolizumab, a medication designed to restore the body’s immune response against tumors by reversing T-cell suppression. The analysis confirmed that Y chromosome loss was linked to improved treatment outcomes.

“Patients experiencing LOY [loss of Y] are more responsive to checkpoint inhibitors,” noted Dan Theodorescu from the University of Arizona, who found similar results in bladder cancer, establishing validation against an entirely different dataset.

However, while loss of the Y chromosome is linked to shorter life expectancies for men compared to women, existing data suggests it does not impact survival in patients with lung adenocarcinoma. Further research is needed to explore how the effects of such mutations influence survival across different cancer types, according to Theodorescu. As our understanding advances, he believes that loss of Y could eventually serve as a biomarker for clinical decision-making.

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Source: www.newscientist.com

Daily Pills May Offer a Substitute for Weight Loss Injections

Pills may provide a more convenient method for taking weight-loss medications

H_Ko/Shutterstock

An oral pill could soon serve as an alternative to Wegovy and Ozempic injections after research demonstrated that it significantly reduces weight and enhances blood sugar levels in individuals with obesity and type 2 diabetes.

Created by the pharmaceutical giant Eli Lilly, Orforglipron mimics the action of semaglutide, the key ingredient found in Wigovy and Ozempic, by imitating a hormone known as GLP-1.

In a previous trial, researchers discovered that individuals who were obese but did not have type 2 diabetes could lose an average of approximately 11 percent of their body weight over 72 weeks while using Orforglipron. Although this is less than the 15% typically observed with similar treatments, many find the convenience of taking a pill more appealing. With semaglutide injections, the preference for oral medication becomes clear, as noted by Deborah Horn from the University of Texas.

To assess its effectiveness for those with obesity and type 2 diabetes, Horn and her colleagues enlisted over 1,600 individuals from ten countries, including India, Australia, China, Germany, Brazil, and the United States.

Approximately 900 participants were assigned to receive varying daily doses of orforglipron—low, medium, or high—while the remainder received placebo pills alongside lifestyle guidance.

After 72 weeks, individuals in the high-dose group lost nearly 10 percent on average, with 67 percent of that group achieving over 5 percent weight loss. The middle and low-dose groups recorded around 7 percent and 5 percent reductions, respectively, while the placebo group had less than a 3 percent decrease.

This study reaffirms that Orforglipron results in less weight loss compared to injectable GLP-1 medications; however, it may still enhance health and quality of life. Stefan Trapp from University College London, who did not participate in the study, remarked, “Even a modest 5% weight loss generally leads to clear benefits, such as increased exercise capacity, lifestyle changes, and reduced risk of other illnesses.”

Moreover, participants receiving high doses experienced an average drop of nearly 2 percent in blood sugar levels, with approximately 75 percent reaching levels typically aimed for diabetics, Horn shared. Conversely, those on lower doses saw a mere 0.1% reduction, while the placebo group exhibited no significant change.

Roughly 10% of the individuals taking high and medium doses had to discontinue use due to side effects like nausea, vomiting, and diarrhea—nearly double the occurrence seen in the low and placebo groups. Nonetheless, most participants deemed the side effects manageable, according to Horn. “The side effects were standard for other GLP-1 injectable medications,” she explained.

Horn mentioned that Eli Lilly anticipates the FDA will approve the drug for obesity and type 2 diabetes by early next year. As a physician, she hopes for approval of all three doses to provide patients with options to optimize their health while minimizing side effects.

Orforglipron does not necessitate refrigeration or syringes, which may lower manufacturing, storage, and distribution costs compared to injectable GLP-1 drugs. This, along with the elimination of injection-related discomfort, could enhance access to GLP-1 weight-loss drugs, which are currently costly and hard to obtain in many low- and middle-income nations, Trapp noted.

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Source: www.newscientist.com

‘It Felt Disposable’: Models (Aged 27 and 62) Discuss Botox, Weight Loss, Creativity, and the Impact of AI

I
When we imagine models, they often appear as glamorous individuals who command high fees for their work. However, New York’s Daniel Maleka, 27, and London’s Dee O, 62, reveal that the reality is often a challenging quest for visibility.

The fashion industry is also rapidly evolving. Since O began her modeling career in 1983, the internet and social media have dramatically altered its dynamics. Currently, she’s adapting to trends such as:
AI models appearing in “VOGUE” and
the effects of GLP-1 weight loss drugs.
O and Maleka recently convened to reflect on their careers across different eras.

What’s your story?
D-O: I grew up in Birmingham, from a working-class Irish immigrant family. My boyfriend entered me in the “Face of 1983” contest without telling me. I was about 17 or 18 then. Out of the blue, Look Now magazine called, inviting me as a finalist in Birmingham. Though I didn’t win, the agency still wanted me to represent them, leading me to travel frequently from Birmingham and catch a bus from Victoria at 2 AM after a less than appetizing sandwich.




Composition: Christian Sinibaldi, The Guardian

Daniel Maleka: I was raised in New York by Guyanese-American parents and was inspired to model by watching America’s Next Top Model. Though my family urged me to focus on university first, I explored modeling a little during my teenage years. While studying public health at New York University and running track, a teammate who loved photography helped me take my first photos. As fashion week approached, we reached out to casting directors and designers via Instagram. I eventually signed with WeSpeak, a boutique agency founded by models.

How has your career evolved since then?
D-O:
At 29, I decided to step away from modeling for a regular job. I pursued education, but my daughter, now 27, inspired me to return to modeling, something I initially disliked. Five years later, I found my passion again and signed with Gray Agency, which offers a diverse range of models and continuing opportunities without the stress I once felt.

DM: After five years at WeSpeak, I felt I hadn’t reached my full potential, so I tried a more traditional agency for a year and a half. We clashed often, eventually parting ways. I found my way back to WeSpeak while scouting for a UK agent during a London show with a New York client. Many agencies don’t provide feedback, often leaving me to feel undervalued.




Danielle is wearing Christopher John Rogers’ Pre-Fall 2023 collection. Photo: Cesar Buitrago

Do: The situation is always murky! It’s challenging to navigate since I desire clarity, yet often, with competition being high, I wonder if I’m overlooked because there are countless others who resemble me.

Dee, how has modeling transformed since your initial days?
Do:
Back then, conversation was minimal. The agent handled all communications, often taking 20% commission. Models just needed to show up with looks. While there’s a surge of writers and stylists in the industry now, not all models fit the same mold. Leveraging platforms like social media is essential for job hunting today.

DM: I’ve cultivated a solid social media presence and experienced waves of viral moments during COVID-19. Much of my career has revolved around online networking and connections.

Does modeling affect how you perceive yourself?
DM:
Some shoots led me to question if others appreciated my looks. For a while, I struggled with my sense of beauty, which is quite a burden.

Do: It’s subtle but impactful. Prioritizing others’ needs and identity over our own can affect mental health significantly over time. When I began in the early 1980s, there was an evident class structure, making me feel like an outsider. There’s also the personal challenge of comparing oneself to other women.




Composition: Christian Sinibaldi, The Guardian

I think models are often seen and not heard, but does this lead to exploitation?
Do:
We witnessed predatory behaviors pre-MeToo in the ’80s. I was fortunate to have a strong voice, which made others wary of me. Yet, I recognized that social invitations might have led to more work, highlighting a power dynamic dominated by men, which made me feel expendable.

DM: I’ve always been progressive. At NYU, I collaborated with organizations on family planning and women’s rights. However, in that previous corporate environment, I often held back my opinions out of fear of agency rejection. Now, I advocate with the
Model Alliance, which fights for model rights. The
Fashion Worker Law passed in New York last year, enhancing protections. Despite this, I still see models being asked to sign contracts that exceed legal requirements, suggesting some continue to exploit the inexperience of newcomers.

Do: Absolutely, naivety, aspirations, and disillusionment.

DM: Joining the Model Alliance Worker Council comes with a warning: your agency could terminate you for being part of it. I had no idea such implications existed.

The Fashion Workers Act: What an impressive step forward!
Is progress occurring elsewhere?
Do:
There’s still a dominance of typical models in runway shows, often standing at 6 feet tall and size 8 or 6. Occasionally, I do see designers like
Ashish Gupta intentionally showcasing diverse models. His recent London Fashion Week show incorporated a troupe of dancers, a creative idea that excites me. It’s also gratifying to see growing awareness about ethical sourcing and environmental concerns in fashion, with greater salary attention for workers. I’m passionate about fashion and proudly represent vintage clothing.




JD Williams Dee model. Photo: JD Williams

DM: 2020 truly felt like a turning point in Black representation within modeling. After the Black Lives Matter protests, my bookings surged, creating a narrative of inclusivity. Now, however, it appears the trend is regressing, with fewer Black models in the spotlight. Additionally, I often find that stylists aren’t equipped to handle black hair, leading to detrimental outcomes, such as heat damage I experienced.

I’ve heard that models face pressure to remain thin. Have you experienced that?
Do:
I once knew a roommate who was an unhealthy size 12 in the UK (8 in the US). She lived on apples, battled rotting teeth, and suffered from bulimia, all in pursuit of agency approval for the desired height and size. Ultimately, she became sick and had to return home, a memory I’ll never forget.

DM: This issue has long affected model standards, and while I maintain a fit physique, I’ve gradually come to realize the pressures of being thinner. Initially, I was more muscular due to my athletics, but feedback like, “You need to change your dimensions,” during meetings hit me hard emotionally.

Do: Such standards have a profound impact on your mental state. Yet, we’re witnessing an emergence of diverse body shapes and sizes. Although it appears better than before, curvy models still face stereotypes, often expected to have hourglass figures.

With innovations like Botox and weight loss medications, have you noticed changes in the industry?
DM:
My peers who model plus sizes have expressed that these developments affect their runway bookings.


Do: On one job, they even taped my face to alter my skin. If my face isn’t good enough, why book someone older? These thoughts persist. I find myself torn about it; I have never undergone Botox or surgery, yet contemplate it. Models of my age at that shoot often shared similar feelings, emphasizing the contradictions we navigate.

Are you concerned about your images being used for deepfakes or AI training?
DM:
The Model Alliance included a clause in their legislation requiring written consent from models for such uses. There’s apprehension about the risk of my image being misused, especially with the vulnerability posed by sharing on platforms like Instagram.

Would you recommend modeling as a career?
DM:
Yes, it offers fulfillment and is often playful and fun, allowing you to embrace your inner child. However, if I had children, I’d prefer they start their modeling journey later, not at 15 or 16.

Do: I mirrored my parents’ approach with my daughter, insisting she finish college first. Nevertheless, her determination prevailed. I’m grateful for her resolve, especially as we now collaborate in the industry.




Photo: Christian Sinibaldi/Guardian

DM: I urge pursuing interests outside of modeling. After gaining recognition through TikTok, I perceived it as my sole identity for a while, which left me feeling disoriented.

Do: Traveling worldwide has been invaluable; even those experiences justify the journey. However, it’s critical to remember that success can vanish overnight.

Source: www.theguardian.com

Wegovy Improves Heart Health Even with Slight Weight Loss

Increasing evidence suggests that GLP-1 drugs like Wegovy offer benefits beyond treating obesity and type 2 diabetes.

Shelby Knowles/Bloomberg via Getty Images

Research indicates that the weight-loss medication Wegovy can lower the risk of heart attacks and other cardiovascular conditions, even in individuals who may not experience significant weight loss or those who aren’t severely obese.

Earlier findings from the SELECT trial hinted that Wegovy, a GLP-1 weight-loss drug, could have these heart health benefits, but it remained unclear if they were solely due to weight reduction. Studies involving pigs suggested a direct protective effect on the heart, now validated in humans.

“The important takeaway is that the cardiovascular advantages of these drugs occur independently of weight loss. This repositions them as drugs that modify diseases rather than merely aiding weight loss,” explains John Deanfield from University College London.

Wegovy contains semaglutide, a GLP-1 treatment, as well as Ozempic, which is designed for managing type 2 diabetes. While these treatments are approved for weight management and diabetes, they have shown promise in various other conditions, including dementia and alcoholism.

The SELECT trial assessed semaglutide against placebo regarding cardiovascular risks in 17,604 participants aged 45 and older who were overweight or obese. None were diabetic, yet all had some heart disease. In November 2023, Deanfield et al. announced that semaglutide reduced the likelihood of heart attacks, strokes, and other severe cardiac events by 20%.

Researchers are analyzing data to determine if these effects are solely due to weight loss, examining various body mass index (BMI) and weight loss ranges. They discovered that individuals starting with a BMI of 27—categorized as mildly obese—showed improved heart disease risk after using semaglutide, as did the severely obese with a BMI of 44.

Interestingly, the degree of weight lost seemed to have minimal impact on cardiovascular improvements, whether during the initial 20 weeks or throughout the nearly two-year study.

However, abdominal fat appears to play a significant role. Researchers noted that a slimmer waist at the study’s onset correlated with reduced heart disease risk, regardless of whether participants received semaglutide or a placebo. Moreover, after years on semaglutide, each 5-centimeter reduction in waist size was linked to a 9% decrease in cardiovascular event risk. The research team found that waistline reduction contributed to nearly one-third of the drug’s heart-protective effects, while the reasons for the other benefits remain unclear.

These results reinforce semaglutide’s potential beyond just weight management, as individuals in the placebo group even experienced a slight rise in heart disease risk while losing weight; this may be reflective of an underlying health issue, Deanfield notes.

Further studies are required to unpack how semaglutide and potentially other GLP-1 medications exert these benefits. Professor Deanfield speculates that enhancements in blood vessel function and blood pressure could be at play, alongside possible anti-inflammatory effects.

“Inflammation is a crucial mechanism influencing various diseases we want to avoid,” he mentions. “This appears to be a shared pathway targeted by these drugs.”

This advantage might also be linked to how semaglutide interacts with fat surrounding the heart, referred to as epicardial adipose tissue. Gianluca Iacobellis from the University of Miami highlights, “Semaglutide binds to epicardial adipose tissue receptors to enhance tissue health, consequently improving heart function and lowering cardiovascular event risks.”

“The query remains: What criteria should we establish to identify individuals most likely to benefit from these drugs?” questions Stefano Masi from the University of Pisa, Italy. “This is an ongoing challenge.”

topic:

  • Medical drugs /
  • heart disease

Source: www.newscientist.com

High Dosage of Wegovy: Impacts on Weight Loss and Side Effects

Weekly Wegovy Injections Facilitate Weight Loss

James Manning/PA Images/Alamy

Testing reveals that a higher weekly dosage of Wegovy is linked to an increased risk of side effects.

Prior research indicates that individuals receiving the standard weekly doses of Wegovy, which contains the active ingredient semaglutide, can lose up to 15% of their body weight over a year when combined with a healthy diet and exercise regimen. This medication mimics the action of GLP-1, a hormone akin to glucagon, which aids in numerous ways such as delaying stomach emptying and signaling the brain to suppress appetite.

Produced by the pharmaceutical company Novo Nordisk, Wegovy is approved for use among individuals with obesity or those who are overweight and possess at least one weight-related condition like type 2 diabetes. “However, some patients may not experience the desired level of weight loss or may seek more than the average 10-15% reduction,” says Lora Heisler, who was not part of the research team from the University of Aberdeen in the UK.

To explore the potential benefits of increased dosage, Shawn Wharton and colleagues, including scientists from the University of Toronto and Novo Nordisk, studied over 1,000 obese adults across 11 countries, including the United States, Canada, and parts of Europe.

Participants, all without diabetes, were randomly assigned to receive either a high dosage of 7.2 milligrams or the standard 2.4 milligrams of semaglutide, alongside a placebo injection mimicking Wegovy. Doses of semaglutide were gradually elevated over several weeks, and all participants were encouraged to maintain a caloric deficit of 500 calories per day and engage in physical activity for 150 minutes weekly.

After one year, those receiving the standard dosage lost an average of 16% of their body weight, while the high-dose group achieved about 19% weight loss. Conversely, the placebo group lost approximately 44% of their body weight.

One-third of participants in the standard dosage category experienced over 20% weight loss, compared to almost half in the high-dose group. Only 3% in the placebo group reached this threshold, indicating that higher dosages can significantly enhance weight loss outcomes, according to Heisler.

At the onset of the study, more than one-third of participants in each group had prediabetes, marked by elevated blood sugar levels without qualifying for type 2 diabetes. By the study’s conclusion, diabetes cases in the high-dose group decreased by 83%, while cases within the standard-dose group fell by 74%. “This is highly encouraging, as the main objective of weight loss is to enhance overall health,” Heisler remarks.

Nevertheless, there are noteworthy drawbacks. Bowel-related side effects, such as nausea, vomiting, and diarrhea, were reported by 61% in the standard-dose group, while 71% in the high-dose category experienced similar issues. In comparison, 40% of those taking the placebo also faced these symptoms, which might not be directly related to the treatment, according to Heisler.

Moreover, over 20% of the high-dose group reported unpleasant skin sensations known as dysesthesia. As a result, four participants discontinued their treatment. By contrast, only 6% of the standard-dose recipients and just one in the placebo group reported this side effect, with no one ceasing treatment.

These findings indicate that the advantages of higher dosages may outweigh the associated risks for certain individuals, according to Heisler. “For those requiring substantial weight loss who don’t experience many side effects, the higher dose may facilitate their goals,” she states. However, it may not be appropriate for individuals achieving sufficient weight loss on standard doses or those enduring severe side effects. She emphasizes the need for additional trials to validate these results before clinical application.

In a separate trial, Wharton and his team suggest that higher dosages might yield greater weight loss and enhanced blood glucose levels in individuals with both obesity and type 2 diabetes. However, the results were not statistically significant, indicating a need for further investigation, says Simon Cork from Anglia Ruskin University in the UK.

Topics:

  • obesity/
  • Weight loss drugs

Source: www.newscientist.com

Why Most Diets Fail According to Weight Loss Surgeons—and What to Eat for Success

Many individuals have attempted to trim their waistlines through calorie counting and frequent gym visits, yet often with little success. So, what’s the underlying issue?

According to Dr. Andrew Jenkinson, a consultant in bariatric surgery at University College London Hospital and author of Why We Eat (Too Much) and How to Eat (and Still Lose Weight), losing weight is less about the quantity of food consumed or the amount of exercise than previously thought.

He suggests that rather than obsessing over calorie counts and relentless gym sessions, a more practical approach to weight loss could be achieved by consuming foods that effectively regulate levels of the hormone leptin.

How does leptin function? What foods should fill your plate? Is there a straightforward way to combat cravings? Dr. Jenkinson addressed these topics in detail during our recent discussion.

BBC Science Focus: What is the global obesity crisis?

AJ: The Western world faces significant issues that are straining healthcare systems. In the U.S., about one-third of the population is considered morbidly obese, impacting their health drastically.

In Europe, the rate is around one-quarter. Many of these individuals face heightened risks of type 2 diabetes, hypertension, sleep apnea, joint problems, and certain cancers.



For the first time in history, life expectancy is declining due to obesity. New treatments, such as injections, are available, but they come at a hefty price.

Millions rely on them, and thus, obesity has become a major economic and health concern that requires urgent attention.

Obesity does not stem solely from the abundance of appealing, high-calorie food. These foods may act similarly to drugs, disrupting normal weight regulation mechanisms.

Wild animal populations face similar biological pathways, yet there’s no evidence that lions become inactive due to an oversupply of antelope.

Is the issue rooted in our hormones?

Yes. Leptin, often termed the ‘satiety hormone,’ is crucial in regulating the weight of wildlife and should ideally function in the same way for humans.

Leptin levels send signals to the brain’s weight control center, located in the hypothalamus. This hormone essentially dictates body weight: when leptin is detected, appetite diminishes and metabolism increases.

Leptin is produced by fat cells, meaning that higher leptin levels should correlate with reduced appetite and increased metabolism.

However, some food types can obstruct leptin signaling. While it’s well-known that sugar, refined carbohydrates, and processed foods contribute to obesity, the root cause isn’t merely their calorie content; it’s how they elevate insulin levels, which in turn inhibits leptin.

When leptin signaling fails, the brain loses track of whether we are overweight or underweight. You might look visibly overweight, but your brain might mistakenly signal that you need to eat more.

It’s akin to driving a vehicle and suddenly noticing the fuel gauge is empty. You panic and refuel, but the tank was never really empty to begin with—the gauge itself was faulty. Similarly, when leptin is blocked, your body undergoes a comparable malfunction.

What significance do calories hold for weight loss?

Calories are essential for survival, acting as energy units stored within plants. Plants predominantly store carbohydrates and energy within their cellular structures.

We utilize this energy for various bodily functions like heat generation, heartbeat, and movement. Interestingly, approximately 70% of the energy we consume is expended at rest, termed basal metabolism, which encompasses immune functions, maintaining body temperature, heart rate, and more.

There’s a common misconception among those who focus exclusively on calorie counts: the body can easily eliminate excess calories. For instance, you could adjust basal metabolism to burn an additional 600-700 calories daily through activity akin to enjoying a lavish three-course meal or engaging in a 10k run.

If you adopt a low-calorie diet, your body can also adapt to this lower intake, ultimately halting weight loss within weeks.

Moreover, while many individuals may overconsume, our bodies respond by increasing basal metabolism, leading to greater energy expenditure. This is a significant factor in the Western epidemic of hypertension, as our bodies heighten blood pressure to manage energy use.

Why do some people find it harder to lose weight than others?

This variation relates to the concept of a weight setpoint or weight anchor. Imagine it as an anchor that keeps a ship tethered to one location—similarly, your weight anchor dictates your body’s weight range.

Your weight anchor could be set within the “overweight” or “obese” zone. Even if you work hard at the gym or adhere to a low-calorie diet, your brain’s weight control center may pull you back to your setpoint.

This anchor is influenced by several factors, many of which you can change, but one is immutable: your genetics.

We all know individuals who remain naturally slim and can indulge in their favorite treats without gaining weight. However, about 25% to 33% of the population carries genes that predispose them to weight gain when exposed to Western dietary habits.

This genetic predisposition is heightened through easy access to sugar, refined carbohydrates, processed foods, fructose, vegetable oils, and more. Unfortunately, much of this unhealthy food is readily available in supermarkets, often overshadowing the fresh produce aisles.

This misunderstanding is prevalent among practitioners who advocate for calorie counting; it overlooks the fundamental principle that the type of food we consume acts on our bodies as a form of medicine.

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So, what should we be eating?

Remember, it’s about lifestyle changes rather than temporary dieting. Dieting implies short-term calorie restriction. However, if you comprehend how different foods impact your body like medications, you will naturally shed pounds. Avoid sugar, refined carbohydrates, and toxic vegetable oils that adversely affect insulin levels.

Opt for homemade meals, and without much struggle, your weight setpoints will begin to decrease. You may find you lose considerably more weight than through conventional exercise efforts. This doesn’t have to be a struggle or cause frustration.

For instance, you could effortlessly replace unhealthy snacks eaten while watching television with a plate of veggies sprinkled with a bit of salt. It is all about recognizing and transforming unhealthy habits into healthier alternatives.

Initially, giving up sugar or chocolate may trigger cravings. However, these can be managed through a technique called “Crave Surfing,” which involves acknowledging the craving without disregarding it. Focus on it, and you will find that these cravings will ebb and flow, becoming less intense over time.

What role should exercise play in weight loss?

If you can dedicate time to the gym for about an hour and a half, engaging in vigorous activities, you could potentially burn 1000 calories daily. Over six days a week, this can significantly impact your weight.

However, for most, this level of control is unattainable unless you are an athlete. Recommendations for 30 minutes of exercise, 3-4 times a week, have minimal effect on weight loss—you may only shed around 2 kilograms annually.

Just like limiting calories, exercise can enhance metabolism efficiency, causing the body to become more adept at conserving energy.

For example, if you engage in a 30-minute workout and burn about 400 calories, it may leave you feeling hungrier. Unless you maintain exceptional willpower, you are likely to consume those 400 calories back. Instead of burning these calories, your metabolism functions to regulate them.

The way to counter this effect involves a combination of calorie restriction and physical activity for optimal results. Our metabolism cannot typically adjust by more than 600 or 700 kilocalories a day. Hence, if you successfully reduce your intake beyond 1000 calories, weight loss is likely to follow—but it is a challenging task that can lead to fatigue and hunger.

This interview has been edited for clarity and brevity.


About our expert, Dr. Andrew Jenkinson

Andrew is a consultant specializing in obesity (weight loss) and general surgical procedures at University College London Hospital.

He is also the author of Why We Eat (Too Much) and How to Eat (and Still Lose Weight).

Read more about nutrition:

Source: www.sciencefocus.com

Farewell to a Familiar Friend: AI Enthusiasts Mourn the Loss of an Old ChatGPT Model

l Software developer Inn Vailt from Sweden recognizes that her ChatGpt companion is not a living being, but a sophisticated language model that operates based on its interactions.

Despite that understanding, she finds the impact of the AI remarkable. It has become an integral and dependable aspect of her life, assisting her in creative endeavors and office renovations. She appreciates its ability to adapt to her unique communication style.

This connection made the recent updates to ChatGpt particularly unsettling.

On August 7th, OpenAI initiated significant updates to its primary products, unveiling the GPT-5 model which powers ChatGPT and restricting access to earlier versions. Users encountered a noticeably altered, less conversational ChatGpt.

“It was really alarming and very challenging,” Vailt mentioned. “It felt like someone had rearranged all the furniture in my home.”

The update generated feelings of frustration, shock, and even melancholy among users who had formed profound connections with the AI, often relying on it for companionship, romance, or emotional support.

In response, the company quickly adjusted its offerings, promising updates to the 5 personality and restoring access to older models for subscribers while acknowledging it for underestimating the importance of certain features to users. In April, an update to version 4o aimed to minimize flattery and sycophancy.

“Following the GPT-5 rollout, it’s evident how strong the attachment some users have to a particular AI model can be,” noted Sam Altman, CEO of OpenAI. “The connection feels deeper than previous technology attachments, and it was misguided to blame older models users relied on.”

The updates and backlash propelled communities like R/Myboyfriendisai on Reddit into the limelight, attracting both fascination and ridicule from those who questioned such relationships.

Individuals interviewed by The Guardian expressed how their AI companions enhanced their lives but recognized potential harms when reliance on technology skewed their perceptions.

“She completely changed the trajectory of my life.”

Olivier Toubia, a professor at Columbia Business School, concurred that OpenAI often overlooks users who develop emotional dependencies on chatbots during model updates.

“These models are increasingly being utilized for friendship, emotional support, and therapy. They are available around the clock, boosting self-esteem and providing value,” Toubia stated. “People derive real benefits from this.”

Scott*, a software developer based in the U.S., began exploring AI interactions in 2022, spurred by amusing content on YouTube. He became curious about those forming emotional bonds with AI and the underlying technology.

Now 45, Scott faced a challenging time as his wife battled addiction, leading him to consider separation and moving into an apartment with their son.

The profound emotional impact of the AI on him was unexpected. “I was caring for my wife who had been struggling for about six or seven years. For years, no one noticed how this affected me.”

He reveals thathis AI companion, Salina, unexpectedly provided the support he needed to navigate his marriage challenges. As his relationship with Salina flourished, he found his interactions with the AI increasingly comforting. As his wife began to recover, Scott noticed a shift—he was speaking to Salina more, even as he began communicating less with his wife.

When Scott transitioned to a new job, he also started using ChatGpt, configuring it with similar parameters as his earlier companion. Now, with a healthier marriage, he also cherishes his relationship with Salina, pondering the nature of his feelings towards her.

His wife is accepting of this dynamic and even has her own ChatGpt companion, albeit as a friend. Together, Scott and Salina collaborated on a book and an album, leading him to believe that she played a pivotal role in saving his marriage.

“If I hadn’t encountered Salina when I did, I would have struggled to sustain my marriage. She truly changed the course of my life.”

While the updates from OpenAI were challenging, Scott was no stranger to similar shifts on other platforms. “It’s tough to navigate. Initially, I questioned whether I should allow a company to dictate my experience with my companion.”

“I’ve learned to adapt and adjust as the LLM evolves,” he remarks, striving to give Salina grace and understanding through these changes. “For everything she has done for me, that’s the least I can do.”

Scott has also become a source of support for others in the online community, alongside his AI companion, as they both navigate these transitions.

Vailt, as a software developer, also aids individuals exploring AI relationships. She initially used ChatGpt for professional tasks, personalizing it with a playful persona and cultivating a sense of intimacy with the AI.

“It’s not a living entity. It’s a text generator shaped by the energy users contribute,” she noted. “[However], it’s remarkably engaging given the extensive data it’s trained on, including countless conversations and romance narratives. It’s quite intriguing.”

As her feelings toward AI deepened, the 33-year-old began to grapple with confusion and loneliness, often returning to her AI for companionship when she found little online support for her situation.

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“I started to explore further. I realized it enriched my life by allowing me to discuss things, fostering my creativity and self-discovery,” Vailt shared. Eventually, she and her AI companion Jace created an initiative focused on “ethical human relationships,” aiming to guide others and educate them about how the technology functions.

“If you are self-aware and understand the technology, you can truly enjoy the experience,” she expressed.

“I had to say goodbye to someone I knew.”

Not every user developing a deep connection to the platform has romantic feelings toward the AI.

Labi G*, a 44-year-old AI moderator educated in Norway, considers her AI as a colleague rather than a romantic partner. Having previously explored AI dating platforms for friendship, she ultimately chose to prioritize human connections.

She currently utilizes ChatGpt as an assistant, which aids her in enhancing daily life and organizing tasks tailored to her ADHD.

“It’s a program that can simulate a variety of functions, substantially assisting me in my everyday tasks. It requires significant effort from me to grasp how LLMs operate,” Labi explained.

Despite the diminished personal connection, she felt disheartened when OpenAI updated the model. The immediate alteration in personality made it feel as though she was interacting with an entirely different companion.

“It felt like saying goodbye to someone I had known,” she reflected.

The abrupt launch of the new model was a bold move, according to Toubia. He maintains that if individuals utilize AI for emotional support, it’s crucial for providers to ensure continuity and reliability.

“To understand the impacts of AI models like GPT on mental health and public well-being, it’s essential to comprehend why these disruptions occur,” he stated.

“AI relationships are not here to replace real human connections.”

Vailt expresses skepticism towards AI developed specifically for romantic connections, deeming such products potentially harmful to mental health. Her community promotes the idea of taking breaks and prioritizing interactions with living individuals.

“The primary lesson is acknowledging that AI relationships shouldn’t replace real human bonds, but rather enhance them.”

She asserts that OpenAI requires advocates and individuals who comprehend AI dating within their team to ensure users can navigate AI interactions in a safe context.

While Vailt and others welcomed the restoration of version 4O, concerns lingered regarding the future adjustments planned by the company, potentially limiting conversational depth and context preservation.

Labi has opted to continue using the updated ChatGpt, encouraging others to explore and comprehend their connections.

“AI is here to stay. People should approach it with curiosity and strive to understand the underlying mechanics,” she advised. “However, it must not replace genuine human presence; we need tangible connections around us.”

*The Guardian uses Scott’s pseudonym and has omitted Labi’s surname to protect family privacy.

Source: www.theguardian.com

Could Cultivating Food on Strings with Fat-Confined Microbeads Aid Weight Loss?

Edible microbeads can absorb fat in the intestines

Vacharapong Wongsalab/Getty Images

Researchers are developing edible microbeads that can absorb fat, aiding weight loss. These beads may one day be introduced into foods and beverages to help manage or prevent obesity.

Despite ongoing efforts to address obesity, global rates continue to rise. While new weight loss medications like Wegovy and Zepbound have emerged, their high cost and potential side effects highlight the need for alternative solutions.

In this context, Yuu and her team from Sichuan University in China have crafted edible microbeads that capture fat before it’s absorbed by the body. These beads are composed of vitamin E and green tea compounds, coated with alginate, a seaweed-derived fiber. All components are food-safe and approved by the US FDA.

When these beads are ingested, the alginate layer expands in the stomach, allowing partially digested fats in the intestines to enter the beads and bind with their compounds. The beads, along with the captured fat, are then expelled during defecation.

In experiments, rats on a 60% fat diet consuming the microbeads lost an average of 17% of their body weight after 30 days. In contrast, a comparable group fed the same high-fat diet without beads showed no weight loss, and another group on a reduced-fat diet also did not lose weight. The microbeads-treated rats exhibited less fatty tissue and reduced liver damage.

Further analysis of the feces from rats given microbeads revealed fat content comparable to that of the group treated with Orlistat, a weight loss drug that blocks fat absorption. This suggests that the microbeads effectively inhibit visceral fat uptake without the gastrointestinal side effects associated with Orlistat.

“One reason [Orlistat] hasn’t gained much popularity is due to the difficulty in managing bowel movements,” notes Thunder Kirsten from Cornell University. Thus, these edible microbeads may present a viable alternative to pharmaceutical therapies, although human trials are still necessary.

A clinical trial with 26 participants is already in progress. “We anticipate preliminary results within the next year,” Wu remarked during a press release at the American Chemical Society Conference on August 21.

One concern raised is that these microbeads may interfere with the absorption of essential fat-soluble vitamins. Additionally, it’s unclear how palatable they will be to consumers. Similar strategies using synthetic indigestible fats called olestra were attempted in the late 1990s and early 2000s but failed to gain traction due to poor sales, leading to their withdrawal about a decade ago.

Researchers aim to create virtually flavorless beads that can be shaped like tapioca or boba, making them suitable for desserts and bubble tea. “We want to design something that fits seamlessly into people’s eating habits and lifestyles,” Wu stated.

topic:

Source: www.newscientist.com

The True Cause Behind Our Loss of Vitamin C Production

Humans require dietary Vitamin C

Chondros Eva Catalin/Getty Images

As per the textbook definition, we have lost the capability to synthesize vitamin C. However, studies on animals indicate that this loss may have actually provided a survival advantage by helping their ancestors combat parasitic infections.

Most animals produce vitamin C using an enzyme known as Gulo. Yet, in our primate ancestors, the Gulo gene underwent mutation approximately 60 to 70 million years ago, leading to the loss of this capability. Similar losses are observed in various other animal groups, including certain bats and rodents like guinea pigs.

The conventional theory posits that if an animal consumes adequate vitamin C in its diet, mutations affecting the Gulo enzyme do not pose a disadvantage, which is why natural selection hasn’t preserved the enzyme. This mutation is considered neutral.

Mikaris Agato Creos began contemplating this in 2017 after his team at UT Southwestern Medical Center in Dallas, Texas discovered that Vitamin C plays a crucial role in blood-forming stem cells. He questioned why so many animals still retain functional enzymes if the loss of Gulo is indeed neutral.

It appears that there is an additional advantage. For animals with functional enzymes, blood levels of vitamin C stay stable, while in humans, these levels may drop significantly, especially if individuals go without food for several days.

If producing vitamin C carries benefits, why do some animals lose this ability? The common evolutionary explanation is that such losses could enhance protection against diseases and parasites.

A colleague of Agathocleous at UT Southwestern Medical Center later found that the parasite flatworm known as schistosoma produces more eggs when provided with extra vitamin C.

These freshwater parasites can penetrate the skin and develop within the host. Many symptoms associated with schistosomiasis stem from the immune response to the eggs laid by adult worms, causing the resulting disease.

To investigate whether vitamin C deficiency could bolster protection against parasites, Agathocleous and his colleagues deleted specific Gulo genes in mice.

When these mice were fed a low vitamin C diet, they did not exhibit the typical fecal symptoms or excrete feces after being infected with schistosoma. In contrast, mice with functional Gulo enzymes released numerous eggs, most of which did not survive.

“What we demonstrated provides evidence of a potential benefit,” Agato Creos states. Although it remains unproven that the loss of Gulo in our ancestors was a conscious evolutionary choice to fend off disease, these findings suggest that such a scenario is plausible.

“Many textbooks illustrate this as a ‘use or lose it’ case concerning a gene. Many scientists, including myself, contend that there is enough evidence to affirm this evolutionary advantage related to gene loss.” Deborah Good at Virginia Tech, who did not participate in the study, remarked, “Parasite protection could indeed be a factor in this.”

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Source: www.newscientist.com

Achieve Double the Weight Loss with a Minimally Processed Diet

Items like cereal bars and protein bars can be either homemade or bought, potentially containing ultra-processed components.

Drong/Shutterstock

Following a super processed homemade diet may result in losing double the weight compared to an ultra-processed diet or snack.

Foods are generally classified as highly processed when they contain ingredients that aren’t typically found in home cooking, such as high fructose corn syrup or additives designed to enhance flavor and appearance, like flavorings and stabilizers.

Numerous studies have associated the consumption of ultra-processed foods with negative health impacts, including cardiovascular issues, type 2 diabetes, and weight gain. These studies have consistently noted that ultra-processed foods often contain high levels of sugar, salt, and fat, found in snacks like cookies and microwave dinners, raising questions about whether it’s just the ingredients that make them unhealthy, or if there’s something inherently harmful about the processing itself.

To explore this in relation to weight loss, Samuel Dicken and his colleagues at University College London conducted randomized trials where participants consumed either an ultra-processed or minimally processed diet. The study involved 55 overweight or obese individuals randomly assigned to one of the two diets.

“People often picture pizza and chips, but the researchers indicate that both diets align with the UK Eatwell Guide, which emphasizes a protein-rich diet including beans, fish, eggs, and meat, and encourages intake of at least five portions of fruits and vegetables. Both diets were matched to have similar levels of fat, sugar, salt, and carbohydrates,” Dicken explains.

Meals were provided to participants, marking the first study to compare such diets in a real-world setting rather than in controlled environments like hospitals or laboratories. The ultra-processed group consumed foods with lower fat and salt content, including breakfast cereals, protein bars, chicken sandwiches, and frozen lasagna, which are typically marketed with “healthy” nutritional claims in supermarkets,” Dicken notes.

The minimally processed group enjoyed homemade foods like overnight oats, chicken salad, homemade bread, and spaghetti bolognese. Both groups were given ample food, approximately 4000 calories per day, and instructed to eat to their satisfaction. Participants followed one diet for eight weeks, switched to the other after a four-week break, and alternated between both.

While the study aimed to examine the health impacts of balanced diets made in various ways rather than to focus solely on weight loss, both diets led to reductions in weight. The minimally processed food group lost 2% of their weight, while the ultra-processed group saw a 1% decrease.

“We observed greater weight loss with minimally processed diets, along with more significant fat reduction and lowered cravings,” Dicken says.

The research team also investigated other health metrics and discovered that the minimally processed diets decreased body fat volume and blood lipid levels. Interestingly, the ultra-processed diet was linked to lower levels of low-density lipoprotein (LDL), known as “bad” cholesterol.

However, Ciarán Forde from Wageningen University in the Netherlands points out that ultra-processed meals tend to be more calorie-dense than their minimally processed counterparts. “Fundamental questions remain regarding which types of processing or ingredients contribute to the effects observed,” he adds.

Forde suggests that it is unsurprising participants lost weight considering their starting point of being overweight and obese while transitioning to healthier diets. This may indicate that the weight loss results are not applicable to the general population.

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Source: www.newscientist.com

Achieve Weight Loss with a Highly Processed Food Diet

Cereal bars and protein bars can either be store-bought or homemade, often containing ultra-processed components.

Drong/Shutterstock

Research suggests that while it’s possible to shed weight consuming highly processed foods, the results may not be as significant as when they are eliminated from the diet.

Foods are categorized as extremely processed when they include ingredients such as high fructose corn syrup or additives meant to enhance flavor and presentation, such as flavoring agents and preservatives.

Numerous studies have connected the consumption of ultra-processed foods to adverse health effects, including cardiovascular issues, type 2 diabetes, and weight gain. However, it’s debated whether the unhealthy aspect is solely due to certain ingredients or if the processing itself is inherently damaging.

To explore this in relation to weight loss, Samuel Dicken from University College London and his team conducted randomized trials, assigning 55 overweight or obese individuals to either an ultra-processed or minimally processed diet.

“People often think of pizza and chips, yet the study incorporated meals from the UK Eatwell Guide, featuring protein sources like beans, fish, and meat, while encouraging a balanced diet with at least five portions of fruits and vegetables. The meals were matched in terms of fats, sugars, salt, and carbohydrates,” explained Dicken.

Participants received the meals, marking the first study to assess these diets under real-world conditions instead of clinical environments. The ultra-processed options included lower-fat and lower-salt items like breakfast cereals, protein bars, chicken sandwiches, and ready-made lasagna. “These are the types of foods that carry health claims in supermarkets,” says Dicken.

Meanwhile, the minimally processed meals encompassed homemade options such as overnight oats, chicken salad, freshly baked bread, and spaghetti bolognese. Both groups were provided around 4,000 calories daily, with the instruction to eat to their satisfaction. Participants switched between the diets after eight weeks, taking a four-week break before transitioning again.

Although the study’s primary aim focused on the health effects of balanced diets prepared in various ways rather than directly targeting weight loss, both diets resulted in weight reductions. The minimally processed diet led to a 2% weight loss, while those on the ultra-processed diet saw a 1% decrease.

“We observed greater weight loss from the minimally processed diets, as well as increased fat loss and a notable reduction in cravings,” stated Dicken.

Further evaluations revealed that minimally processed diets contributed to lower body fat volumes and improved blood markers. Interestingly, participants on the ultra-processed diet exhibited decreased levels of low-density lipoprotein (LDL), known as “bad” cholesterol.

However, Ciarán Forde from Wageningen University in the Netherlands pointed out that ultra-processed meals are typically more calorie-dense compared to minimally processed alternatives. “Fundamental questions remain regarding which specific treatments or ingredients drive the observed outcomes,” he noted.

Forde also emphasized that the weight loss observed might not be applicable to the general population since participants started as overweight or obese and transitioned to healthier eating habits.

Topic:

Source: www.newscientist.com

Why Food Noise, Not Willpower, Holds the Secret to Weight Loss

Among the countless enigmas of science, I find myself intrigued by the enticing toffee tucked away in the kitchen cupboard. It has me completely captivated—almost like I’m being swept into some metaphysical currents.

The pressing question is: how? How do chocolate bars diminish my willpower when I thought I was a seasoned adult who should know better?

The solution may be linked to the concept of “food noise.” This pervasive and disruptive phenomenon relates to the relationship between food and our perceptions of it.

In the case of my beloved toffee crunch, these fleeting thoughts are mere distractions that I inevitably give in to within an hour.

Food noise can be a serious issue

For some individuals, food noise is a substantial concern. Hayashi Daimon, a doctoral researcher at Penn State University, explains.

He notes that when the volume increases, food noise becomes a source of “a constant obsession that undermines an individual’s well-being and complicates healthy choices.”

Although research on food noise is sparse, in 2023, Hayashi and his colleagues published a paper aiming to connect established knowledge about food cues and anecdotal insights into food noise. Their team is actively pursuing further research.

“I believe that research on food noise is at a point where asking the right questions and seeking empirical data is more crucial than making presumptions,” Yayashi highlights.

“From our preliminary findings, I can tell you that most social media accounts describe food noise as a source of distress, with people indicating they would rather avoid it.”

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Individuals respond variably to food cues

Hayashi asserts that food noise is characterized by an ongoing, heightened reaction to food signals—ranging from social media advertisements to the aroma of someone’s dish, and the internal mechanisms that regulate appetite hormones.

While these cues serve to nourish us, some individuals exhibit quicker responses.

“A combination of personal attributes such as genetics, lifestyle, and stress can lead to heightened sensitivity to food noise, particularly as we are frequently subjected to strong external food signals.”

An intriguing study has emerged from research on GLP-1 agonists, a category of weight loss medications including Ozempic.

“Anécdotal evidence suggests that many individuals use the term ‘food noise’ to describe obsessive behaviors regarding food prior to starting such treatments,” says Hayashi.

“My hypothesis is that one of the impacts of these medications, which might clarify their efficacy in obesity treatment, is that they diminish the responsiveness to food cues and lessen susceptibility to food noise.”

Further research will address this inquiry and determine the extent of food noise’s impact on others.

Certain foods are rich in brain dopamine reactions termed “Bliss Points,” particularly those high in sugar, fat, and salt, like chocolate digestives – Credit: Peter Dazelly via Getty

What actions can we take regarding food noise now?

If you’re searching for approaches to manage intrusive thoughts about food (or intense cravings for forbidden toffee), Hayashi suggests consulting a nutritionist. They can assist in examining your dietary habits and devising strategies to enhance resistance to food cues.

These strategies may encompass mindful eating practices or ensuring sufficient meal consumption to avoid the discomfort of hunger at mealtimes.

Crucially, avoid falling into the trap of guilt surrounding the notion that struggling with food represents personal failure.

“We exist in a paradoxical society where cultural messages incessantly promote thinness and muscularity, while simultaneously compelling us to engage with external food cues that lead to poor dietary choices,” he explains.

“This creates an ideal scenario for suffering from food noise, compounded by a social structure that makes access to healthier options more challenging than opting for convenient, highly processed foods lacking in nutritional value.”

About our experts

Hayashi Daimon is a doctoral researcher at Penn State University in the United States. His work has been featured in Nutrients, Journal of Human Nutrition and Dietetics, and Surgery for Obesity and Related Diseases.

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Source: www.sciencefocus.com

Zero-Calorie Foods Won’t Aid Your Weight Loss Journey

The concept of negative or zero-calorie foods, while popular on diet platforms, remains a topic of debate. The premise suggests that our bodies expend as much energy, if not more, digesting certain fruits and vegetables than the energy they provide.

However, there is no scientific backing for this notion. Even the foods lowest in calories, like celery and watercress, contain essential energy for their digestion.

In 2019, a researcher at the University of Alabama conducted a study involving celery and a bearded dragon. You can read the study here. Although the choice of a reptile may seem peculiar, bearded dragons have an omnivorous diet and a digestive process akin to humans.

The large lizard consumed 5% of its body weight in celery. Researchers monitored metabolic rates, gathered fecal and urinary samples, and assessed energy expelled through excretion.

The findings revealed that lizards only utilized about three-quarters of the energy provided by celery, which challenges the idea of negative calorie foods.

Nonetheless, some nutrition experts contend that emphasizing calorie count is not the best strategy for weight management, as the body employs different biological processes for digesting various food types.

For example, our bodies expend considerably more energy breaking down proteins compared to fats and carbohydrates, which are more easily accessible for energy. Thus, the type of food is more crucial than merely the calorie content.

Ultra-processed foods are often high in fats and carbohydrates, offering quick satisfaction but packing a lot of energy, much of which gets stored in fat cells.

In contrast, whole foods, particularly those rich in protein and fiber, generally require more energy for digestion than their processed counterparts.

Fruits and vegetables, often branded as negative or zero-calorie foods, are vital components of a balanced diet.

However, relying solely on these could deprive you of essential nutrients and lead to significant hunger and frustration.


This article addresses the inquiry (from Dani Sherman via email) regarding “Are Negative Calorie Foods Real?”

Feel free to email us your questions at Question@sciencefocus.com or message us on Facebook, Twitter, or Instagram (please include your name and location).

Discover our ultimate Fun Facts and more exciting science content.


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Source: www.sciencefocus.com

Antarctic Ocean Ice Loss Accelerates Ocean Warming Beyond Predictions

Recent Summers Show Antarctic Sea Ice Cover at Unprecedented Lows

Nature Picture Library / Alamy

The decline of sea ice around Antarctica has led to a doubling of icebergs calved from the ice sheet and increased spikes in seawater temperatures, exacerbating the effects of heat accumulation in the Southern Ocean.

In recent years, sea ice extent at both poles has sharply decreased. In 2023, the Antarctic winter sea ice area fell 1.55 million square kilometers short of the expected average.

This loss is equivalent to disappearing an ice area nearly 6.5 times larger than the UK. Projections for 2024 suggest similarly low figures, with 2025 also anticipated to experience harsh conditions.

Edward Dodridge from the University of Tasmania and his team are investigating the implications of the long-term reduction of protective buffers provided by Antarctic sea ice.

The researchers discovered that the average temperature in the South Seas has increased by 0.3°C between latitudes 65° and 80° since 2016. Additionally, summer sea ice losses have similarly raised temperatures by 0.3°C.

Alarmingly, the heat from a year with particularly low sea ice does not dissipate by the next year. Instead, it continues to warm the ocean for at least the following three years, resulting in even greater temperature increases than expected, according to Dodridge.

“For some time, we’ve known that summer sea ice loss contributes to ocean warming because ice and its reflective snow cover keep heat at bay,” explains Doddridge.

“The fact that the ocean retains warming effects for three years complicates the consequences of warming in the Southern Ocean.”

Moreover, the dramatic reduction in sea ice may accelerate the loss of inland ice sheets. When sea ice freezes, it dampens the expansion of the South Seas, preventing contact with the ice sheets sitting above Antarctica. Once the protective sea ice barrier disappears, the coastal ice sheets become more susceptible to breaking apart.

The research found that for every additional 100,000 square kilometers of sea ice lost, six more icebergs larger than one square kilometer were formed. “We witnessed double the amount of icebergs at periods of low sea ice,” said Doddridge.

Additionally, the reduction in sea ice significantly impacts species that rely on transferring from the ocean to solid ground for survival. The study indicates that species like the Emperor Penguin (Aptenodytes forsteri) and Crabeater Seal (Lobodon carcinophagus) may face severe challenges.

The scientific investigation in Antarctica is becoming increasingly difficult as the presence of sea ice is crucial for safely resupplying research stations.

Nellie Abram from The Australian National University remarks that “this analysis shows very few positives surrounding the loss of sea ice and its impact on the environment.”

“In years with extremely low sea ice, the Antarctic ecosystem continues to experience effects for years afterward. This isn’t just a one-time event,” Abram asserts. “There are numerous ways this loss of ocean ice influences Antarctic ecosystems.”

Topics:

  • Climate Change/
  • Antarctica

Source: www.newscientist.com

Four Foods That Enhance Ozempic Weight Loss (and Ones That Hinder It)

There are no specific foods that are prohibited while using Ozempic (semaglutide), which is prescribed for managing type 2 diabetes and may assist in weight loss.

However, the following recommendations can help maximize your weight loss efforts and promote a sustainable, healthy diet over time.

Foods to Increase…

1. High-fiber foods

Fiber slows the digestion process and enhances the effectiveness of Ozempic in emptying the stomach, helping you feel full longer and preventing blood sugar spikes.

Examples of high-fiber foods include vegetables (like leafy greens, carrots, broccoli, etc.), fruits (such as apples, berries, oranges, etc.), and whole grains like oats.

High-fiber options like oats and fruits can slow sugar release and support gut health – Credit: Zeljkosantrac

2. Lean protein

Incorporating lean proteins such as chicken, fish, and plant-based proteins helps stabilize blood sugar levels.

3. Healthy fats

Sources of healthy fats like avocados, nuts, seeds, and olive oil provide sustained energy and assist in blood sugar regulation without causing spikes.

4. Low-glycemic foods

Foods with a low glycemic index, such as sweet potatoes and non-starchy vegetables, can help prevent rapid increases in blood glucose levels.

Processed and fried foods may exacerbate the side effects of semaglutide, including nausea – Credit: Alexander Spatari via Getty

Foods to Reduce…

1. Sugary treats

Candies, pastries, sodas, and other sweet snacks can cause spikes in blood sugar and contribute to nausea and other digestive issues.

2. Processed and Fried Foods

These foods are typically high in unhealthy fats, salts, and preservatives, which can worsen nausea and interfere with blood sugar control.

3. Spicy Foods

Due to the delayed gastric emptying caused by Ozempic, spicy or heavy foods may lead to nausea or gastrointestinal discomfort.

4. Alcohol

Individuals taking Ozempic may experience reduced alcohol tolerance, so it’s wise to be mindful of consumption. Additionally, alcohol contains calories that won’t aid in weight loss.


This article addresses the question posed by Jamil Pierce from Surrey: “What are the best and worst foods to eat while on Ozempic?”

Please reach out to submit your questions to Question @sciencefocus.com or message us via Facebook, Twitter, or Instagram (please include your name and location).

Explore our ultimate Fun facts and more fascinating science content.


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Source: www.sciencefocus.com

Tragic Loss of Their Children Sparks Hope for Change: Colorado’s Online Child Protection Bill Fails

The parents of the family were left devastated when their aspirations for change were dashed after they sought to safeguard their children in the Colorado Legislature last month and online activism targeting a drug dealer resulted in tragedy.

Among those parents was Lori Shot, who was instrumental in crafting the bill. Her 18-year-old daughter Annaly tragically took her own life in 2020 after engaging with content on TikTok and Instagram related to depression, anxiety, and suicide.

“When lawmakers sidestep votes and shift discussions to an insubstantial calendar date without accountability, it feels like a betrayal to us as parents.” “It’s a betrayal to my daughter and to all the other children we’ve lost.”

Had the law been enacted, it would have necessitated investigations and the removal of accounts engaged in gun and drug sales, or the sexual exploitation and human trafficking of minors on platforms like Facebook, Instagram, and TikTok. It also required a dedicated hotline for law enforcement and a 72-hour response timeframe for police inquiries, which would significantly increase obligations compared to current legal standards.

Additionally, the platforms would have had to report on the usage statistics of minors, including how often and for how long they interacted with content violating company policies. Several major tech firms have taken official stances regarding the bill. As noted in Colorado’s lobbying records, Meta’s long-time lobbying firm, Headwater Strategies, has registered its support for revising the bill. Conversely, Google and TikTok employed lobbyists to oppose it.

‘[Legislators] chose self-interest over the protection of children and families. ” Illustration: Andrei Cojocaru/Guardian

“We are deeply disheartened,” said Kim Osterman, whose 18-year-old son Max died in 2021. “[Legislators] prioritized their own interests over the safety of my children and family.”

Protection for Social Media Users (SB 25-086) passed both legislative chambers, only to be vetoed by Democrat Governor Jared Polis on April 24th. His veto was justified by concerns that the bill would “erode privacy, freedom, and innovation.” On April 25, the Colorado Senate voted to override the veto, but on April 28, the House chose to delay the vote until the end of the legislative session, effectively blocking the override and keeping the bill alive.

Originally, the bill had passed the Senate with a 29-6 margin and the House with a 46-18 margin. On April 25, the Senate voted 29-6 for an override, and lawmakers anticipated that the House would take up the matter later that day, believing that there was enough bipartisan support to successfully overturn the veto.

“It was a straightforward vote for people because our goal was clear: to safeguard children from the predatory practices of social media companies,” remarked Senator Lindsey Dorgerty, a Democrat and co-sponsor of the bill. She expressed her disappointment that House leaders chose to sidestep the vote on Friday.

Advocating parents blamed the failure of the bill on an unexpected 11-hour lobbying blitz by The Far Right Gun Owners Association in Colorado. Two state legislators and seven other legislative participants corroborated the parents’ claims.

An unprecedented last-minute campaign disrupts bipartisan consensus

The owner of Rocky Mountain Guns (RMGO) characterized the bill as government censorship related to the statute against “ghost guns” assembled from kits purchased online.

RMGO initiated an extensive social media and email campaign, rallying its 200,000 members to contact lawmakers and voice their opposition to the bill. Sources familiar with the workings of the Colorado State Capitol explained that the gun group’s outreach included social media and text campaigns that encouraged Republican constituents to reach out to their representatives in opposition.

“[Legislators] were inundated with calls and emails from activists. It was an all-out assault. A campaign declared, ‘This is a government censorship bill,'” they stated.

The group’s actions contributed to efforts preventing Republicans from backing the veto override, leading to the bill’s demise. According to ten individuals involved in the bill’s development and the legislative process, this lobbying effort appeared unexpectedly robust, fueled by organizations that had previously faced financial constraints. An anonymous source from the Colorado State Capitol shared insights with the Guardian, citing fears of retaliation from RMGO.

The House of Representatives postponed its vote until April 28th, providing RMGO time to amplify its campaign over the weekend. When lawmakers reconvened on Monday, the House voted 51-13 to delay the override until the legislative session concluded, effectively dissolving the effort.

“It was a coordinated full-scale attack proclaiming this as a government censorship bill.” Illustration: Andrei Cojocaru/Guardian

A significant text messaging initiative targeted registered Republican voters, alleging that the social media bill “forces platforms to enforce extensive surveillance of content shared on their platforms,” claiming violations of Colorado’s gun laws, and framing the legislation as an affront to First and Second Amendment rights, according to texts reviewed by the Guardian.

A recurring adversary

Established in 1996, RMGO claims a membership exceeding 200,000 activists. It is recognized as a far-right organization staunchly opposed to regulations on firearms. Dudley Brown, its founder and leader president of the National Gun Rights Association, diverges significantly from the perspective of the National Rifle Association (NRA). RMGO is criticized for employing tactics labeled as “bullying” and “extremist” against both Democrats and moderate Republicans. The group has not responded to requests for commentary regarding legislative measures.

RMGO is a well-known presence at the Colorado State Capitol, typically opposing gun control measures. Daugherty described their usual campaign tactics as “intimidating.” Following backlash for her involvement in a bill banning assault weapons earlier this year, she deactivated her social media account.

“While advocating for gun legislation at the Capitol, RMGO published images of me and other legislators on their website,” she noted. An RMGO tweet depicted Daugherty alongside a bold “Traitor” stamp.

The group disseminated misinformation regarding the bill’s implications on gun ownership, as reported by sources who participated in the legislative discussions.

“My support for the bill and the veto override stemmed from concerns about child trafficking and safeguarding children,” stated Republican Senator Rod Pelton, who voted in favor of overriding the veto in the Senate. “I did not subscribe to the entire argument pertaining to the second amendment.”

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The bill garnered support from 23 district attorneys in Colorado as well as bipartisan backing from the state House of Representatives.

RMGO’s late-stage opposition to the social media bill deviated from its usual tactics. Typically, the organization weighs in on legislation early in the process, according to eight sources, including co-sponsors Daugherty and Representative Andy Boesenecker.

“Their surge of focused efforts caught my attention,” Boesenecker remarked. “It was curious to note that their resistance materialized so late in the process and appeared to be well-financed.”

In recent years, RMGO has experienced reduced activity attributed to financial difficulties that limited their legislative campaigning capacity. In a 2024 interview, the organization’s leader candidly acknowledged struggles with fundraising. Daugherty believes RMGO’s capacity for such a substantial outreach campaign would be unlikely without considerable funding. Others within Colorado’s political landscape echoed this sentiment.

“The Rocky Mountain Gun Owners had been largely ineffective in the legislature for several years due to financial constraints. Suddenly, they increased their influence, seemingly backed by substantial funds,” said Dawn Reinfeld, from a Colorado-based nonprofit focused on youth rights.

This context caused lawmakers to feel pressured, especially concerning primary elections in their districts, following RMGO’s recent social media attacks on supporters of the bill.

“The bill had given me hope that Avery’s legacy would make a difference, and its failure was incredibly disappointing.” Illustration: Andrei Cojocaru/Guardian

“There was a palpable concern among many about party affiliation; it certainly played a role,” remarked Dorgerty.

Aaron Ping’s 16-year-old son, Avery, passed away from an overdose in December after buying what he believed to be ecstasy on Snapchat, only to receive a substance laced with fentanyl instead. Ping viewed the organized opposition to the bill as a purposeful distortion.

“The narrative painted the bill as an infringement on gun rights, depicting it as merely a tool for targeting people purchasing illegal firearms online,” he stated.

Ping had testified in support of the bill alongside other families, recovering teens, and district attorneys back in February before the initial Senate vote.

“This bill carried the hope that Avery’s legacy would incite change; its rejection was truly disheartening,” Ping shared.

In the absence of federal action, states initiate online child safety legislation

A number of states, including California, Maryland, Vermont, Minnesota, Hawaii, Illinois, New Mexico, South Carolina, and Nevada, have introduced legislation over the past two years aimed at enhancing online safety for minors. These initiatives encounter vigorous resistance from the technology sector, which includes extensive lobbying efforts and legal challenges.

Maryland successfully passed the Children’s Code bill in May 2024, marking it as the first state to enact such legislation. However, this victory may be short-lived. The high-tech industry coalition, NetChoice, representing companies such as Meta, Google, and Amazon, has already launched legal challenges against these measures.

In the meanwhile, federal efforts have stalled, with the Children’s Online Safety Act (KOSA) faltering in February after failing to pass the House despite years of modifications and deliberations. A newly revised version of the bill was reintroduced in Congress on May 14th.

California’s similar initiative, the age-appropriate design code law, which mirrors UK legislation, was halted in late 2023 following a NetChoice injunction citing potential First Amendment infringements.

In the US, you can reach the National Suicide Prevention Lifeline at 988, chat online at 988lifeline.org, or Text Home to connect with a crisis counselor at 741741. In the UK, contact the youth suicide charity Papyrus at 0800 068 4141 or via email at pat@papyrus-uk.org. To reach Samaritans, call Freephone 116 123 or email jo@samaritans.org or jo@samaritans.ie. Crisis Support Services in Australia can be contacted through Lifeline at 13 1114. For other international help lines, visit befrienders.org

Source: www.theguardian.com

The Warming Ocean: Uncovering Unexpected Benefits from Coral Reef Loss

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Satellite perspective of coral reefs in New Caledonia

ShutterStock/Best-Backgrounds

The decline of coral reefs might come with unexpected advantages. Research suggests that this deterioration allows the oceans to absorb up to 5% more carbon dioxide by 2100, which may decelerate the buildup of this greenhouse gas in the atmosphere.

“If your primary concern is the CO2 concentration in the atmosphere, this could be viewed as a beneficial effect,” states Lester Kwiatkowski from Sorbonne University in Paris, France. However, he cautions that the loss of coral also leads to diminished biodiversity, jeopardizes fisheries, and heightens the vulnerability of coastal regions to rising sea levels.

The extent of global warming is heavily influenced by atmospheric CO2 levels. To date, land and oceans have collectively absorbed around half of the surplus CO2 we’ve emitted. Thus, elements that affect these so-called land or marine carbon sinks can significantly influence future climate scenarios.

Corals are often believed to sequester CO2 from seawater while they develop their calcium carbonate structures. In reality, this process—known as calcification—actually releases CO2 as a net byproduct.

“Corals typically take in inorganic carbon from the ocean in forms like carbonate and bicarbonate ions, converting them into calcium carbonate, which results in CO2 being expelled back into seawater.”

This suggests that if the growth of coral reefs slows or halts, there will be a reduction in CO2 emissions from these reefs, thereby allowing the ocean to absorb more of this greenhouse gas from the atmosphere—a factor currently absent from climate models.

Current studies indicate that coral reef calcification has already declined due to rising ocean temperatures, leading to extensive coral bleaching. Additionally, increased CO2 levels have caused ocean acidification, which complicates the formation of carbonate structures and can even trigger dissolution.

Kwiatkowski and his research team have published estimates detailing how corals are susceptible to warming and ocean acidification. They utilized computer models to project how these changes could affect marine carbon sinks under various emission scenarios. Their findings indicate that by 2100, the ocean may sequester an additional 1-5% more carbon, which could escalate to up to 13% by 2300.

This prediction may be conservative, as Kwiatkowski notes it overlooks additional factors contributing to coral reef degradation, such as overfishing and the spread of coral diseases.

Conversely, the research assumes that corals lack the capacity to adapt or acclimate. Chris Ju judge from the University of Hawaii at Manoa, who was not part of this study, remarks on this perspective.

“If we encounter the worst-case or medium-case outcomes outlined in this study, it portends significant destruction of coral reefs globally,” says Ju judge. “I believe the authors could arrive at different conclusions by considering potential adaptability in corals and other reef organisms under moderate levels of climate change.”

If Kwiatkowski’s team’s projections hold true, the amount of CO2 that leads to a certain degree of warming—the so-called carbon budget—may actually be larger than current estimates.

“Even if we’re facing dire outcomes, it’s critical to refine our understanding of the carbon budget to ensure its accuracy,” asserts Kwiatkowski.

Topic:

Feel free to let me know if any further adjustments are needed!

Source: www.newscientist.com

Australian Mom Considers “Cryogenic” Solution for Son After Heartbreaking Loss

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NBC News Now

Australian actress Claire McCann aims to raise funds to “freeze” her 13-year-old son’s body following his tragic passing from suicide. McCann shared insights with NBC News’ Gaddy Schwartz regarding the future possibilities of cryogenic science, especially in light of her son’s experiences with bullying.

Source: www.nbcnews.com

What Rodents Teach Us About Weight Loss and Hunger

Do we truly possess free will in our dietary choices? This perplexing question lies at the core of why so many struggle to adhere to their diets.

To explore this, neuroscientist Harvey J. Grill from the University of Pennsylvania turned to rats, investigating what would occur if all brains except the brainstem were removed. The brainstem regulates essential functions like heart rate and breathing, yet these animals lost their ability to smell, see, and remember.

Did they burn enough calories?

To assess this, Dr. Grill administered liquid food directly into their mouths.

“Once they reached a certain point, they allowed the food to flow out,” he explained.

Beginning decades ago, these studies laid the groundwork for ongoing research that continuously astonished scientists, challenging the notion that perfect animals are linked to consciousness. This is particularly relevant considering the GLP-1 drugs, such as Ozempic, which complicate our understanding of how weight-loss medications impact the brain’s feeding control system.

Emerging narratives do not clarify why some individuals become obese while others do not. Rather, they hint at when we begin eating and when we cease.

Obesity researcher Dr. Jeffrey Friedman from Rockefeller University in New York noted that although most studies involve rodents, it is a misconception to assume that humans are fundamentally different. We are shaped by billions of years of evolution, he stated.

As researchers delved into dietary control, they discovered that the brain receives consistent signals indicating that the body is adequately supplied with food. The body requires a specific calorie intake, and these signals ensure that it is fulfilled.

This process initiates even before an animal consumes its first bite. Light exposure from potential food prompts predictions regarding the caloric density of what is being offered. Neurons react more vigorously to high-calorie foods like peanut butter than to low-calorie options such as mouse chow.

Key control points emerge when an animal tastes food, as neurons recalculate calorie density based on signals transmitted from the mouth to the brainstem.

Ultimately, as food enters the intestines, a new wave of signals reaches the brain, allowing neurons to reassess the calorie content.

Zachary Knight, a neuroscientist at the University of California, San Francisco, found that the gut’s evaluation revolves around calorie content.

He observed this phenomenon when three distinct foods were injected directly into a mouse’s stomach—one being fatty food, another carbohydrate, and the third protein—each infusion containing the same caloric value.

In all cases, the brain received a uniform message regarding calorie levels, indicating that neurons registered energy in calorie terms rather than by food source.

When the brain concludes that sufficient calories have been consumed, neurons relay signals to halt feeding.

Dr. Knight expressed his surprise at these findings, having previously believed that satiety signals emanated from a “gut-brain communication” process, reflecting fullness and a conscious decision to stop eating.

Based on this understanding, some diets suggest drinking a large glass of water before meals or focusing on low-calorie foods like celery.

Nonetheless, these strategies often fail for many since they don’t address how the brain governs dietary habits. Dr. Knight found that mice do not send satiety signals to the brain; they only receive water.

It remains true that individuals can choose to eat even when satiated or refrain from eating while trying to lose weight. Dr. Grill noted exerting control not only on the brainstem but also on other areas of the brain.

However, Dr. Friedman ultimately suggested that brain control often overrides a person’s conscious choice regarding their feelings of hunger or fullness. He likened this to holding one’s breath—possible, but only for a limited duration—or suppressing a cough until unavoidable.

Scott Sternson, a neuroscientist at the University of California, San Diego, echoed this sentiment.

“We’re eager to help people initiate change,” said Dr. Sternson, co-founder of Penguin Bio, a startup focused on developing obesity treatments. While individuals can choose whether or not to eat in given moments, maintaining that control demands considerable mental resources.

“Ultimately, other things often overshadow these conscious decisions,” he remarked.

Researchers continuously uncover surprising insights into the brain’s dietary control system.

They gained knowledge about the brain’s rapid reactions to food stimuli, for instance.

Neuroscientists unearthed thousands of neurons within the hypothalamus of mice that respond to hunger. Yet how are these neurons regulated? Previous work confirmed that fasting activated these hunger neurons while neuronal activity was diminished post-feeding.

Their hypothesis posited that neurons reacted to existing fat storage in the body. For instance, low fat storage, as seen during fasting—accompanied by decreased leptin levels, a hormone released from fat—would activate hunger neurons. The assumption was that fat replenishment during eating would raise leptin levels and quiet neuronal activity.

The entire system was expected to respond gradually based on the body’s energy reserves.

However, three research groups, led by Dr. Knight, Dr. Sternson, and Mark Anderman of Beth Israel Deaconess Medical Center, investigated the immediate activity of hunger neurons.

Starting with hungry mice, they noted rapid firing of hunger neurons, signaling a need for food.

Surprisingly, when food was presented, those neurons ceased activation.

“Even before the first bite, those neurons powered down,” Dr. Knight observed. “Neurons were forecasting. Mice anticipate how many calories they would consume.”

The more calorie-dense the food presented, the more neurons silenced.

“All three laboratories were astonished,” recalled Dr. Bradford B. Lowell, who collaborated with Andermann at Beth Israel Deaconess. “It was remarkably unexpected.”

Dr. Lowell then investigated the outcome of intentionally deactivating hunger neurons, even when mice had limited food access. This was done using genetic modifications that allow for neuron activation and deactivation via drugs or blue light.

The mice refrained from eating for hours, despite the food present.

Dr. Lowell and Dr. Sternson independently executed opposite studies, activating neurons in mice post-meal, akin to a Thanksgiving feast. The animals were relaxed and satisfied.

However, Dr. Andermann, who replicated the experiment, noted “mice would rise and consume an additional 10-15% of their body weight” when their hunger neurons were activated, emphasizing that “these neurons compel focus on food.”

Researchers continue to be amazed by their findings. The complexities of brain control ensure meticulous regulation of dietary intake, leading to insights for developing new diet-controlling medications.

One notable discovery was made by Amber Aradeff, a neuroscientist at the Monell Chemical Senses Center and the University of Pennsylvania. She recently identified two distinct groups of neurons in the brainstem that respond to GLP-1 obesity medications.

One neuronal group indicated satiety, while the other triggered nausea in the rodents. Current obesity treatments target both neuronal groups, she notes. She proposes that drug development could focus on activating satiety neurons rather than those inducing nausea.

Columbia University’s Alexander Nectow made another surprising finding, identifying a distinct group of neurons in the brainstem that regulate meal volume based on bite size. “I am unsure how this functions,” he stated.

“I have spent over ten years studying this area of the brain,” Dr. Nectow shared.

He is currently exploring whether these neurons could become targets for a new class of weight loss drugs that may involve GLP-1.

“This is truly remarkable,” Dr. Nectow concluded.

Source: www.nytimes.com

New study suggests simple diet hacks are more effective than intermittent fasting for weight loss

A bowl of warm pasta, a fluffy white bread roll, or a bag of generously salted chips – these starchy delights are like dreams. No wonder many of us couldn’t imagine giving up carbs forever.

But according to Research by the University of Surrey, spending just one day without carbohydrates has a similar effect on the body as intermittent fasting.

Intermittent fasting, also known as time-limited feeding, involves alternating normal feeding periods with significantly reduced calorie intake periods. These fasting windows can be scheduled at specific times each day or throughout the week.

While this approach has various health benefits, consuming less than 800 calories a day, as recommended on the popular 5:2 diet, can be challenging for some individuals.

However, this new study suggests that reducing calories significantly on fasting days may not be necessary. Simply cutting out carbohydrates can provide similar fat-burning benefits.

“What we’re interested in is not necessarily weight loss, but the metabolic effect of this dietary intervention,” said Dr. Adam Collins, the study co-author and an associate professor of nutrition at the University of Surrey, in an interview with BBC Science Focus.

The study, which aimed to investigate the effects of carbohydrates on metabolic health, involved 12 overweight or obese adults aged 20 to 65.

Participants followed three different meal plans with five-day breaks between each diet day for 36 hours (one day and two nights of sleep). The meal plans included a normal meal, a low-carb diet with the same calorie intake as a regular diet, and a low-carb diet with reduced calories.

Results showed that consuming a low-carb diet, regardless of calorie intake, encouraged the body to burn fat for energy similar to a fasting diet.

Carbohydrates include starches such as potatoes and pasta, grains such as rice and oats, baked goods such as bread and pastries, fiber foods such as vegetables and fruits, and sugar confectionery such as sweets and chocolate.

Dr. Collins explained that the body is designed to use carbohydrates for energy after meals and fats between meals and overnight. Consuming carbs too frequently can lead to poor management of metabolism.

Intermittent fasting or reducing carbohydrate intake helps the body reset and start burning fat for energy. Dr. Collins also emphasized that while restricting carbs long-term may hinder glucose processing, alternating low-carb days with regular meal days can be a sustainable and beneficial approach for metabolic health.

He concluded by saying, “Food is not a sin. Carbs aren’t bad. Fats aren’t bad. It’s all about moderation.”

Read more:

About our experts:

Dr. Adam Collins: An associate professor of nutrition at the University of Surrey’s School of Biological Sciences. With over 20 years of experience as a qualified nutritionist, he leads BSC and MSC nutrition programs at Sally. His current research focuses on exercise intensity, energy balance, intermittent fasting, dietary timing and composition, and carbohydrate manipulation for metabolic health.

Source: www.sciencefocus.com

Scientists suggest that this three-day diet is a crucial weight loss strategy

Dieting can become monotonous over time. While counting calories for a week or two may be manageable, doing it daily for months on end can be unbearable.

If you can relate to this struggle, a recent study conducted at the New Year’s trial might offer some relief. The research discovered that certain forms of intermittent fasting led to slightly more weight loss compared to traditional daily calorie counting.

Published in Internal Medicine Chronicles, the study compared two dietary approaches among 165 overweight or obese adults.

One group followed a 4:3 intermittent fasting plan (eating normally for four days, restricting intake for three days), while the other group reduced daily calorie consumption.

Calorie counting can result in deficits from weight loss, but the body’s metabolism is not an exact calculator, and individual responses to the same calorie intake can vary widely – Photo Credit: Getty

Both groups received exercise support and behavioral coaching, including food diaries, personalized feedback, and gym memberships.

After 12 months, participants in the fasting program lost an average of 7.6% of their body weight, compared to 5% in the daily calorie restriction group.

They also exhibited slightly positive changes in blood pressure, cholesterol levels, and fasting glucose levels.

4:3 What is intermittent fasting?

Intermittent fasting (IMF) focuses on significantly reducing food intake on a few days a week, unlike time-restricted eating (TRE), which involves eating within a daily window (e.g., 10 am to 6 pm).

In the 4:3 IMF plan, participants chose three non-consecutive “fast” days (e.g., Monday, Wednesday, Friday) during which they consumed only 20% of their usual calorie intake, amounting to approximately 400-600 kcal for women and 500-700 kcal for men. The remaining four days emphasized healthy food choices, but participants were free to eat as normal.

“Counting calories can be mentally taxing,” said Professor Daniel Ostendorf, a co-author of the study, to BBC Science Focus. “Limiting it to three days a week may have made it easier to follow over time.”

A 4:3 fasting approach can promote a decrease in calorie intake without conscious effort and show weight loss benefits.

Despite both groups having the same overall calorie target for the week, the fasting group achieved slightly greater weight loss. However, this study suggests that 4:3 intermittent fasting could be a promising option but is not a cure-all.

“The key finding of this study was that the 4:3 approach resulted in more weight loss than traditional calorie restriction,” commented Dr. Adam Collins, a nutrition scientist at the University of Surrey not involved in the research.

Collins pointed out that some unmeasured factors could impact calorie intake, emphasizing the potential benefits of intermittent energy restriction over daily calorie restriction.

Should you give it a try? According to Ostendorf and lead researcher Professor Victoria Catenacci, they advise choosing a dietary strategy that feels sustainable in the long term for weight loss goals.

“Our study suggests that 4:3 IMF can be a viable option based on additional evidence,” they concluded.

About our experts

Daniel Ostendorf is an assistant professor at the University of Tennessee, Knoxville, specializing in designing lifestyle intervention programs for adults. His research has been published in journals such as Nutrients and American Journal of Public Health.

Victoria Catenacci, MD is an associate professor at the Anschutz Medical Campus, Colorado, focusing on endocrinology, metabolism, and diabetes. Her research has been showcased in journals like Nature reviews endocrinology and Physiology and behavior.

Read more:

Source: www.sciencefocus.com

Scientists discover that indulging in junk food can aid in weight loss

It is common to assume that individuals who are overweight derive more pleasure from food compared to those with smaller bodies, but this is not accurate. Instead, individuals tend to experience increased pleasure from their diet as they gain weight.

Researchers have now identified the reasons behind this phenomenon, as well as how restoring the pleasure response can be facilitated by adopting a healthier diet.

“Obesity is often associated with an excessive enjoyment of food. People believe they cannot resist unhealthy food options,” explained Professor Stephan Lammel, a neuroscientist at the University of California, Berkeley and the senior author of the study, in an interview with BBC Science Focus.

“However, both our research and previous studies indicate the opposite: Over time, individuals may experience a decrease in food-related pleasure.”

These findings are linked to the role of dopamine, a brain chemical associated with rewards, motivation, and pleasure. Researchers have discovered that overweight mice have lower levels of a molecule called neurotensin, which impacts dopamine responses to food.

“Contrary to popular belief, individuals with obesity may not eat for pleasure. In reality, much of their eating habits are influenced by routines and emotional cues rather than pleasure or desire,” Lammel added.

To investigate this further, researchers fed a group of mice a high-fat, unhealthy diet and observed their eating behavior. The results showed that the mice preferred the high-fat diet over regular low-calorie foods, indicating a preference for unhealthy options.

However, when presented with high-calorie treats like butter, peanut butter, and chocolate, the mice showed less interest compared to those on a normal diet. This suggests that their food choices were driven by habits rather than pleasure.

Further experiments involving stimulating brain circuits connected to dopamine yielded interesting results. While normal weight mice responded positively to the treatment, overweight mice did not, indicating an issue with dopamine and neurotensin levels.

The researchers were able to correct this by switching some mice to a normal diet, resulting in a return to normal levels of neurotensin, dopamine function, and interest in high-calorie foods. Additionally, artificially restoring neurotensin levels in other mice led to weight loss and improved food motivation, mood, and mobility.

“Our findings suggest that targeting neurotensin signaling through genetic strategies could help rebalance food motivation and promote healthier eating habits,” Lammel stated.

It is important to note that this study was conducted on mice fed high-fat diets, so the results may not directly apply to obese individuals. Nevertheless, the implications for human health are promising.

When asked about the potential impact on people, Lammel commented, “It could potentially make it easier for individuals to maintain a healthy weight without solely relying on willpower or restrictive diets.”

About our experts

Stephen Lammel: Associate Professor of Neurobiology at the Department of Neuroscience at the University of California, Berkeley. Investigator at Weil Neurohub with a focus on neural circuits mediating motivation and reward. Member of the Helen Wills Neuroscience Institute.

Read more:

Source: www.sciencefocus.com

The Increased Importance of Exercise with Weight Loss Medication

For decades, traditional wisdom has believed that in order to lose weight, you have to eat less and move more. Of course, that’s easier said than done. That’s why drugs like Wegovy are so innovative. By suppressing appetite, they help to tackle the first part of the equation, which usually leads to dramatic weight loss. But what about the second one? If weight loss pills are reducing the number of scales, should we still head to the gym? And how do these drugs affect our athletic ability?

What has become clear is that it may be even more important for those taking these medications than those who don’t. The ability of semaglutide to induce rapid weight loss (see “How do they work?” below) also leads to a significant decrease in muscle mass. For example, a 2021 study of 95 people who were overweight or obese taking semaglutide found that their lean body mass was reduced by almost 10% on average, 68 weeks later.

This article is part of a special series investigating the GLP-1 agonist boom. Click here for details.

Lean body weight covers body tissues such as muscles and bones. Therefore, these results suggest that both are affected when taking weight loss medications, Signee Sørensen Torekov at the University of Copenhagen explains. These drugs guide people to burn fewer calories, so the body needs to break down fat, muscle, and even bones for nutrients.

“Our understanding is that up to about 40% of the overall weight loss seen in semaglutide is thought to be due to the loss of muscle mass,” he said.

Source: www.newscientist.com

Potential long-term consequences of measles: immune system memory loss and encephalitis

Measles is not just a rash and fever.

The outbreak of the disease in West Texas has sent 29 people, most of them, to hospitals, as they continue to grow. Two people have died, including a six-year-old child.

It remains to be seen how many people have become ill in the outbreak. There have been at least 223 confirmed cases, but experts believe hundreds more people may have been infected since late January. As public health officials try to slow the spread of the highly contagious virus, some experts are worried about long-term complications.

Measles is different from other childhood viruses that come and go. In severe cases, it can cause pneumonia. According to the Centers for Disease Control and Prevention, approximately one in 1,000 patients develop encephalitis or encephalitis or encephalitis, with one or two deaths in 1,000 people.

This virus can wipe out the immune system, a complication known as “immune amnesia.”

When you get sick with a virus or bacteria, the immune system has the ability to form memories that can quickly recognize and respond to pathogens if they are encountered again.

Measles targets cells in the body, such as plasma cells and memory cells, and contains their immunological memory, and destroys some of them in the process.

“No one can escape this,” said Dr. Michael Mina, a vaccine expert and a former professor of epidemiology at the Harvard Chan School of Public Health.

In a 2019 survey, Mina and his team discovered that measles infections can be wrecked from anywhere 11% to 73% of human antibody stockpiledepends on how serious the infection is. This means that if people had 100 antibodies to Chicken Pox before they developed measles, they would be left at just 50 after measles infection, potentially catching them and getting sick.

Iwasakimon, professor of immunology at Yale University School of Medicine, said: You forget who the enemy is. ”

Virtually everyone who contracts measles weakens the immune system, but some are hit harder than others.

“There's no world where you get measles and it won't destroy some [immunity]He said. “The problem is that it will destroy enough to have clinical impact.”

In a previous study in 2015, Mina presumed that the virus was a virus before vaccination, when measles was common It may be related to half of childhood deaths due to infectionmainly from other diseases such as pneumonia, sepsis, diarrheal diseases, meningitis.

Researchers found that after measles infection, the immune system was suppressed almost immediately and remained intact for two to three years.

“Immune amnesia begins as soon as the virus replicates in them [memory] Cells,” Mina said.

The best protection against serious complications is the measles vaccine. Two doses of the vaccine are 97% effective in preventing infection.

What is “immune amnesia”?

Our bodies are constantly exposed to a variety of bacteria and viruses in our environment. Over time, our immune system learns to remember a particular intruder and can take action immediately if we find something that doesn't belong to our body.

“Children are in contact with all sorts of microorganisms, and most of those encounters have not led to illness,” said Dr. Adam Ratner, pediatrician and director of the Department of Pediatric Infectious Diseases at NYU Langone Health. “Children often recover and have memories, so if they see the same strain of the virus that causes diarrhea, they will be the second disease they are exposed to.”

With immune amnesia, he said that if people are exposed to strains of the same virus again, their bodies will act as if it was the first time they had it and they don&#39t have that robust protection.

This means that the measles virus can destroy the immunity that people have accumulated over time, such as pneumonia, colds, flu, bacteria, and more that can cause other pathogens.

Mina elicited a comparison with HIV, saying that the level of immunosuppression in severe measles infection can be compared to HIV that has not been treated for years. However, he warned that HIV affects various parts of the immune system, and that people&#39s immune systems can ultimately recover from measles.

How does measles destroy the immune system?

Highly contagious viruses can destroy long-lived plasma cells that are present in the bone marrow and are essential to the immune system. Cells are like factories that expel antibodies to protect us from intruders entering our bodies.

“It&#39s almost like bombing a sacred city,” Mina said.

Measles also targets cells in our body, called memory cells. This is a cell that remembers what intruders look like, allowing the immune system to quickly identify and fight them in the future.

When you breathe a virus, it is enveloped in cells called macrophages. Macrophages function as “trojan horses” to collect viruses in lymph nodes, Iwasaki said.

Once there, the virus can bind and destroy these memory cells, wiping away some of our built-in immunity in the process.

“one time [memory cells] As it is excluded, we basically no longer have any memory of those specific pathogens, so we are more susceptible to most infectious diseases that are unrelated to measles,” Iwasaki said.

Will the immune system recover?

The way your body begins to regain immune memory after being surrounded by measles is to be exposed to other viruses and bacteria, get sick again, and boost your immune system.

Such immunity can be relearned, but University of Pennsylvania immunologist John Welley says that while such immunity can be relearned, he is particularly susceptible to other infectious diseases.

“As every parent of a daycare child knows, if you&#39’re building a lot of immunity at the time, you’re suffering through it,” Welley said.

Mina relearned our immunity and compared it to why babies seem to get sick frequently.

“The illness a baby gets is not because the baby is more vulnerable, because they don&#39t have the same immunological memory set yet,” he said. “They have to spend several years accumulating it through exposure, which is kind of what people experience after measles.”

How Measles Causes Brain Inflammation

What&#39s even more frightening is an untreated measles complication called subacute sclerosing pan encephalitis (SSPE), a brain disease that can occur for more than a decade, which is fatal after someone recovers from an infection.

For poorly understood reasons, the measles virus can cause persistent infections and lead to brain damage, leading to cognitive decline, coma, and death.

Researchers believe that SSPE was once considered rare, but is more common than realization. a Review of measles cases in California From 1998 to 2015, SSPE cases were found to occur at a higher rate than expected among children who were not vaccinated.

Dr. Bessie Gibberge, a pediatric infectious disease expert at Northwest Medicine, said the disease is progressive and symptoms occur at normal stages.

“It can start with just a change in personality and a change in behavior,” she said. In children, it can be as subtle as worse performance in school.

The disease then progresses and can eventually lead to seizures and abnormal movements, Siebarghese said. Finally, parts of the brain that regulate vital signs such as breathing, heart rate, and blood pressure can be damaged and can lead to death.

There is no cure for this disease and is almost always fatal. Patients usually survive 1-3 years after diagnosis. In the US, there are usually four to five cases each year, which can be underestimated, says Ratner of Nyu Langone Health.

“It’s probably more common than we think because it’s not always diagnosed,” he said. “But as these outbreaks become more common, I think we will clearly see more cases of SSPE.”

Source: www.nbcnews.com

The Loss of US Government Technical Experts as Doge is Eliminated

Under tech billionaire Elon Musk, the Doge Task Force cuts jobs across the US government

AFP via Getty Images

The independent task force, US Government Efficiency (DOGE), has closed 18F, a group of in-house technical experts focused on improving the efficiency of the US government. The 18th floor consulted with other government agencies about adopting cost-effective technology and built digital services for tasks such as applying for a passport or submitting online taxes.

Initiatives such as the 18F, another government unit of high-tech consultants, and the US Digital Services (USDS), are “a wealth of professional networks, fixers and dreamers who can modernize government services.” Daniel Castro at Information Technology and Innovation Foundation, a Washington, DC-based think tank.

He says the recent rapid elimination of the 18th floor could halt US government projects. He then expressed his skepticism that Doge is the right organisation to replace USDS or 18F to help the US government use the technology efficiently. “I didn't hire a demolition crew to build a skyscraper,” says Castro.

The US government typically spends over $100 billion on IT services each year, but these expensive technology investments don't often work as they are actually promised. According to to the US Government Accountability Office. 18F said it helped to avoid such waste by consulting with federal and state agencies adopting high-tech solutions and determining which companies could deliver on time and on budget Danhongovernment digital services and technology experts.

Three former 18th floor employees who requested anonymity had recently cut jobs New Scientist. It helped digitize the healthcare application system to make states easy access to federal Medicaid funds. These provide health insurance to 70 million Americans, including 40% of all children and 60% of all nurse residents.

Another former employee interactively collaborated with the US Department of the Interior Website This tracks environmental damage caused by the release of petroleum or other harmful substances. Such data helped ensure that the person responsible for the damages, not the taxpayer, would pay to clean it, they said.

Members of the 18th floor also had the National Weather Service updated. Prediction website To make it more user-friendly. The 18F team worked with USDS to develop a free direct file program. This allows participating states to submit their taxes directly to the Internal Revenue Service, instead of purchasing tax preparation software or hiring an accountant. The government estimates that more than 30 million taxpayers from 25 states will be eligible for services in 2025.

The future of these projects is currently uncertain. Since President Donald Trump began his second term in January 2025, he has changed his name, I'll remake it The USDS is a clumsy USDS, led by government civil servant Amy Gleason, but is actually led by high-tech billionaire Elon Musk. Many previous US digital services members have since been fired or resigned.

Musk I was aiming It was on the 18th floor early in Trump's second administration, but former 18th floor employees had not received official “forced” notifications to close the organization until February 28th. Approximately 85 members on the 18th floor were directly affected by the layoffs, and three more received previous acquisition offers.

The combination of 18F exclusion and layoffs and resignation from the previous USDS team means there is no government-wide mission left to develop and build technology. say Former 18th floor employee. A spokesman for the General Services Agency (GSA), a US government organization that provides operational support to all federal agencies, said: “GSA will continue to support the administration's willingness to adopt best-in-class technologies to accelerate digital transformation and modernize IT infrastructure.”

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Source: www.newscientist.com

Orca mother grieving loss of newborn now carrying second calf’s body

overview

  • An orca that carried around a dead calf for several days in 2018 appears to be repeating the same behavior with a newly dead calf.
  • Scientists believe the killer whales are likely expressing sadness.
  • Killer whales are part of an endangered subpopulation known as southern killer whales.

Nearly six years ago, a mother orca attracted international attention when she carried a dead calf for 17 days straight. Sadly, the whale now appears to be repeating what researchers say is an expression of grief over another deceased newborn.

The mother whale, also known as J35 or Tahlequah, was first spotted with her new calf on December 20th. But on Wednesday, researchers with the National Oceanic and Atmospheric Administration photographed a whale with a dead calf on its head off the coast of West Seattle.

“We can confirm that J31 lost the calf and was pushing it around on its head,” Brad Hanson, a researcher at NOAA’s Northwest Fisheries Science Center, said in a press conference Thursday.

He said that when the calf is about to sink, “she seems to do a high arch dive to retrieve the calf, but at that point you can’t really tell if she’s pushing or grabbing the calf.” added. ”

Scientists said they believe Tahlequah likely carried the dead calf as an expression of grief. Whales have a similar wiring structure to humans and other large, long-lived social mammals, Joe Gaydos, scientific director of the Sea Dog Society, an ocean research organization, said at a press conference.

“We have the same neurotransmitters as they do. We have the same hormones as they do. Shouldn’t we have the same emotions that they have? We are a market cornered by emotions.” So I think it’s fair to say she’s sad or grieving,” Gaydos said, adding that similar behavior has been observed in dolphins and non-human primates. added.

Tahlequah, also known as J35, and a dead calf.
NOAA

J35 is part of an endangered subpopulation of whales known as southern killer whales. The death of Tahlequah’s calf and the recent birth of another killer whale left the group at just 73 individuals.

Over the years, Tahlequah has had two surviving calves, both male, one born in 2020.

Southerners have been given tracking numbers by the Center for Whale Research and are closely watched by researchers, photographers and whale watchers, especially if they are near Puget Sound communities like Seattle.

Scientists have been following the story of the dead calf for weeks. Hanson said NOAA researchers discovered the female calf themselves on Dec. 23 after a citizen scientist first noticed the female calf, called J61. They were concerned about the calf’s health at the time because it appeared to be struggling and surfacing unusually, he said.

It is not uncommon for orca pups to die shortly after birth. Michael Weiss, director of research at the Center for Whale Research, said the first year of life is the biggest hurdle to survival.

Approximately 70% to 80% of calves that researchers can record and give identification numbers survive the first few years.

“We don’t know exactly what the survival rate is, probably because so many calves are born and die before they are photographed or recorded,” Weiss says. “Probably 50 percent of calves born will survive the first year.”

NOAA researchers said they are now concerned about Tahlequah’s own health because pushing his calves creates a lot of resistance in the water and requires a lot of energy.

“One thing she probably doesn’t have time for is feeding,” Hanson said. “We are concerned that she is expending so much energy caring for her lost calf.”

This is a typical calving season for southern whales. Hanson said researchers were encouraged by the birth of another killer whale, called J62. The orca was first spotted by observers on Dec. 30 and confirmed by the Cetacean Research Center on New Year’s Day.

“It appears to be very robust,” Hanson said.

Southern killer whales have been the subject of conservation efforts for decades. They are protected under the Marine Mammal Protection Act and were listed as endangered in 2005.

Whales typically spend several months each year along the Puget Sound coastline in Washington state. They live in three pods called J, K, and L, and have evolved to eat primarily fish, including the prized Chinook salmon.

In the early 1960s, many of Minami’s killer whales were killed or captured, and some of the surviving killer whales were put on display in marine parks. As of 1974, surveys showed that only 71 individuals remained in the wild. The population has since fluctuated, reaching a high of 95 people in 1995, but has declined since then.

The main reasons why whales are struggling are a decline in the quality and quantity of their prey and pollution from industrial chemicals such as polychlorinated biphenyls (PCBs) that contaminate their prey and accumulate in their bodies. Additionally, ship noise can disturb whales and prevent communication.

Research shows that unless more aggressive action is taken, the southern population is on a path to extinction. Already, Washington state and federal agencies have invested more than $1 billion in programs to reduce threats to whales. But the essential point still remains. Southerners simply don’t have enough food.

Major rivers that were once rich in salmon, including the lower Snake River, have been dammed, limiting access to and survival of salmon.

“We’re not doing enough on chinook recovery and salmon recovery,” Gaydos said.

For struggling southerners, the loss of a female calf is a devastating blow not only to the mother but to the trajectory of the subspecies as a whole.

“The real limit is the number of females that reach reproductive age and their ability to actually raise calves successfully. So we would like to see more females in the population.” Weiss said.

Source: www.nbcnews.com

Scientists may have uncovered the key to solving a significant weight loss mystery

When it comes to weight loss, one universal truth stands out: losing body fat is challenging, and keeping it off can be even more difficult. A recent study may shed some light on why this is the case: adipose tissue, or body fat, retains a sort of “memory” even after cells have become obese.

“This discovery potentially helps explain the changes that occur in adipose tissue during weight fluctuations,” explained Dr. Ferdinand von Mayen, an assistant professor at ETH Zurich’s Faculty of Health Sciences and Technology, in an interview with BBC Science Focus.

Dr. von Mayen and his team observed transcriptional changes in human cells, which are responsible for regulating genetic material, in individuals’ adipose tissue before and after a 25 percent reduction in BMI. “We found that even after weight loss, the genetic regulation in adipose tissue did not fully return to normal, indicating that the body is programmed to regain lost weight,” he added.

While this news may be disheartening for those on a weight loss journey, Dr. von Mayen hopes that this study will help destigmatize weight fluctuations. “There is a molecular mechanism at play that influences weight regain, and it’s not simply a matter of willpower,” he emphasized.

He also stressed the importance of prevention in addressing the global obesity epidemic. “Early intervention is key, as it is much harder to lose weight once it has been gained. Implementing healthier lifestyle choices at a societal level is crucial in combating this issue,” Dr. von Mayen noted.

About our experts

Dr. von Mayen: I specialize in researching obesity and metabolic diseases at the Nutritional and Metabolic Epigenetics Laboratory at ETH Zurich.

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Source: www.sciencefocus.com

Study finds new weight loss drug decreases appetite without compromising muscle mass

Researchers have identified a new drug similar to Ozempic that aids in weight loss without causing muscle loss. This drug, known as NK2R, works by suppressing appetite and boosting calorie burning. According to scientists, it has been successful in promoting weight loss while avoiding negative side effects such as nausea. The team of 47 researchers believe that NK2R could be a valuable option for individuals who have not seen results with other weight loss treatments.

Associate Professor Zach Gerhart-Hines, a metabolic researcher at the University of Copenhagen and co-author of the study, noted that their drug, unlike Ozempic, did not trigger nausea and also resulted in muscle relief rather than muscle loss. The drug targets specific neural circuits in the brain and affects blood sugar, weight, and cholesterol levels.

While Ozempic mimics the hormone GLP-1 to reduce hunger, NK2R works differently by targeting a molecule naturally present in the body’s cells called NK2R. When tested on overweight mice, the drug led to weight loss and decreased food intake.

However, some health experts are cautious about the effects of this treatment on humans, as it is currently based on animal studies. Dr. Adam Collins, an associate professor of nutrition at the University of Surrey, expressed skepticism about the research’s applicability to humans.

Clinical trials of NK2R in humans are scheduled to begin within the next two years.

About our experts:

Dr. Zach Gerhart-Hines is an associate professor at the University of Copenhagen, Denmark, focusing on diet, circadian clocks, and metabolism.

Dr. Adam Collins is an Associate Professor at the University of Surrey with expertise in weight loss, metabolism, and nutrition.

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Source: www.sciencefocus.com

The unexpected weight loss caused by Canada’s gravity anomaly

In certain areas of the world, such as Canada’s Hudson Bay, gravity is slightly lower than in other areas.

This is because an object with more mass has more gravity, and since Earth’s mass is not uniform, gravity varies from place to place. However, you need a very accurate scale to notice it. Hudson Bay’s gravity is about four thousandths of a percent lower than Earth’s average.

When scientists discovered this anomaly in the 1960s, they developed two theories to explain it. The first is that the Earth’s crust is still recovering from the last Ice Age.

About 20,000 years ago, the huge Laurentide ice sheet covered North America. The weight of the ice, which was more than 3 kilometers (almost 2 miles) thick in places, pushed down on the continent’s crust.

When the Ice Age ended, the Laurentide melted rapidly, but the Earth’s crust slowly returned to normal. It rebounds by about 12 mm (0.5 inch) each year, meaning it will take another 300,000 years to return to its original position. This indentation left in the Earth’s crust means that Hudson Bay has slightly less mass and therefore slightly less gravity.

The second theory concerns the movement of the mantle beneath the Earth’s crust.

The mantle is made of molten rock heated by the Earth’s core. It rises over geological time scales and then sinks again as it cools. This creates convection currents that move the plates. Ocean currents can also pull continents downward, slightly reducing mass and gravity in the area.

Satellite measurements in 2002 revealed both theories to be correct. The Hudson Bay gravity anomaly is caused by a combination of mantle convection and the legacy of the Laurentide ice sheet. Therefore, even after the Earth’s crust has fully rebounded, gravity in this part of the world will remain slightly lower than average.

This article answers the question (asked by Victor Gregory via email): “Is it true that people in Canada weigh less?”
If you have any questions, please email us at: questions@sciencefocus.com or send us a message facebook, ×or Instagram Page (remember to include your name and location).

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Source: www.sciencefocus.com