U.S. mRNA Cancer Vaccines: Projected Costs Exceed $75 Billion

Vaccine Development

Significant Economic Benefits of mRNA Cancer Vaccines Currently Under Development

Eugene/Getty Images

In August 2025, the United States announced a $500 million cut in funding for vaccine development, jeopardizing the potential advantages of mRNA cancer vaccine research. According to Alison Galvani from Yale University and colleagues, this reduction poses significant risks to future developments.

The team’s analysis indicates that the treatment advancements observed in current clinical trials could prevent nearly 50,000 deaths, translating to an economic value of $75 billion. “This estimate is based on just one annual cohort of patients for each cancer type,” stated the researchers.

Experts caution that diminishing federal investment in mRNA vaccine technology risks undermining these crucial benefits.

Recent research highlights that many of the most effective cancer treatments leverage the body’s immune response to combat tumors. mRNA vaccines can specifically activate the immune system to identify proteins unique to cancer cells, offering a tailored approach to cancer treatment.

To evaluate the potential impact of these vaccines, Galvani and her team analyzed 32 ongoing mRNA cancer vaccine clinical trials in the U.S. They identified the top 11 promising trials and estimated the additional years of life these treatments could provide if widely administered to eligible patients within a year.

Furthermore, the researchers calculated the annual value of an additional year of life, utilizing statistical measures regarding how much individuals would pay for such benefits. They applied values established by the U.S. Department of Health and Human Services to assess the implications of potential regulatory shifts.

Although the annual estimates may be optimistic—given that some vaccine candidates may not gain approval—Oliver Watson from Imperial College London employed a similar framework, estimating that COVID-19 vaccines have yielded global health and economic benefits ranging from $5 trillion to $38 trillion.

If researchers evaluated the cumulative value of multiple cohorts receiving cancer treatments and extended their analysis over a longer time frame, the potential benefits would be substantially greater. “These estimates are undoubtedly conservative,” Watson notes.

Topics:

Source: www.newscientist.com

Independent Estimates of Gaza’s Death Toll Exceed Official Figures

SEI 256827338

Buildings destroyed in Gaza, February 2025

Imago/Alamy

According to an independent survey derived from household interviews, about 75,000 individuals (3.6% of the population) in the Gaza Strip lost their lives due to violence between October 7, 2023, and January 5, 2025. This figure exceeds the Gaza Health Ministry’s estimate of 46,000 violent deaths in the same timeframe.

The research also indicated that approximately 9,000 additional non-violent deaths occurred during this period compared to expected norms in the Gaza Strip. This marks the first estimate of indirect deaths stemming from the conflict that began in October 2023.

The survey involved interviews with 2,000 randomly selected households, which detailed the current and prewar conditions for all household members. “We were present on-site and gathered data directly from the population,” says Debarati Guha-Sapir at Louban Catholic University in Belgium.

The research team encountered restrictions in several locations due to ongoing combat and Israeli evacuation orders, but they believe these limitations likely understate the actual figures rather than exaggerate them.

Guha-Sapir notes that Gaza’s Ministry of Health maintains strict death counting standards. For instance, deaths of unidentified bodies, such as those buried in tunnels, are excluded from the counts. This leads her to conclude that their estimates may closely reflect the true numbers.

Another independent study published in February determined that the death toll up to June 24, 2024, surpassed the official count. However, this study relied on online research and social media obituaries, making Guha-Sapir regard the current research approach as more credible.

Francesco Checchi from the London School of Hygiene & Tropical Medicine, which conducted the February research, disagrees, stating, “The findings aren’t necessarily more accurate than ours.” Nonetheless, he acknowledges that Guha-Sapir’s research is more recent and includes indirect deaths, providing a more comprehensive mortality picture.

The estimated 9,000 indirect deaths from the conflict is lower than previous estimates. For example, a letter in The Lancet in 2024 suggested that for every direct death, there could be four indirect deaths in Gaza, projecting a death toll of around 186,000.

However, Guha-Sapir points out that the direct death rates observed in countries like Sudan, where extreme poverty and inadequate healthcare predate the conflict, do not apply to Gaza’s context prior to the war. This distinction is crucial in interpreting the current situation.

Nevertheless, changes may occur if conditions continue to deteriorate. “As the situation worsens, the rate of non-violent deaths could escalate quickly,” warns team member Michael Spagat from Royal Holloway University in London.

Topics:

Source: www.newscientist.com

Confirmed: Global Warming to Exceed 1.5℃ Limit in 2024

The sun sets on a hot day in London in July 2024.

Guy Corbishley/Alamy

Hopes for keeping global warming below 1.5C above pre-industrial levels have all but disappeared after new data confirms that 2024 will be the first calendar year in which average temperatures exceeded that threshold.

Last year was the hottest year in human history, and the World Meteorological Organization (WMO) is expected to issue its latest stark warning later today that humans are pushing the Earth’s climate into uncharted territory.

Officials are also expected to confirm that this year’s average global temperature exceeded pre-industrial standards by 1.5 degrees Celsius for the first time, breaking the threshold set by the Paris Agreement.

The WMO assessment is calculated using global average temperatures across six datasets and uses the period 1850-1900 to provide a pre-industrial baseline. Temperature datasets collected by different agencies and agencies around the world vary slightly, mainly due to differences in how ocean temperatures are measured and analyzed over the decades. Some of these datasets fall just below the 1.5°C mark. new scientist I understand, but others are much better.

The Met Office predicts average temperatures in 2024 to be 1.53°C above pre-industrial levels, with a margin of error of 0.08°C. This is 0.07°C higher than the previous warmest year on record, in 2023. Meanwhile, according to the European Union’s climate change service Copernicus, temperatures in 2024 will be 1.6 degrees Celsius higher than before the industrial revolution and 0.12 degrees Celsius higher than the record set in 2023.

Scientists agree that the main causes of rising temperatures are continued human-induced climate change and El Niño patterns, which tend to push up global temperatures. But the scale and persistence of the heat has shocked many experts, who had predicted that temperatures would drop once El Niño ended in May 2024. Instead, Temperatures remained at record levels throughout the remainder of the year.

The world’s oceans are the most affected, with sea surface temperatures remaining at record levels through most of 2024, wreaking havoc on marine ecosystems. The year also saw no shortage of extreme weather events on the ground, including intense heatwaves, plummeting polar ice, deadly floods, and out-of-control wildfires. “This year was a year in which the effects of climate change were felt across the planet,” he says. david kingformer Chief Scientific Adviser to the UK Government and founder of the Climate Crisis Advisory Group.

Technically, the Paris Agreement goal of limiting global warming to below 1.5°C is calculated using a 20-year average, so even just one year above the threshold does not constitute a formal violation of the goal. It is not meant to be shown. But given the pace of warming in recent years, many scientists say the long-term Paris goal is no longer achievable.

At the press conference on January 9th, Samantha Burgess Professor Copernicus told reporters that it would probably be impossible to meet the goals of the Paris Agreement. “There is an extremely high possibility that the long-term average temperature will exceed 1.5 degrees Celsius and the upper limit of the Paris Agreement,” he said.

duochan from the University of Southampton in the UK is helping develop a new global dataset, DCENT, which he says uses cutting-edge technology to provide a more accurate historical picture of warming levels. It is said that a baseline is being generated. Although not included in WMO’s calculations, this new data set suggests global average temperatures in 2024 were 1.66°C above pre-industrial levels, he said.

As a result, Chan also believes that the 1.5°C target is probably no longer achievable. “We need to prepare for the broader future, and 1.5°C is not the only target we need to aim for,” he says. But he stressed that this is also an important time to be even more ambitious in reducing emissions. “It’s too early to give up,” he says.

The outlook for 2025 remains uncertain. There are early signs that global sea surface temperatures are finally starting to fall to expected levels. “This is a good sign that at least heat is dissipating from the ocean surface,” Burgess said. Meanwhile, after months of anticipation, La Niña phenomenon finally occurs near the Pacific equatorThis should reduce global temperatures until 2025.

But Chan cautions that if temperatures follow the pattern of past El Niño events, the world could have experienced a gradual change in warming. “Every time we have a major El Niño event… we are basically taking global warming to a new level,” he said, adding that 2024 could be the first time in years that average temperatures exceed 1.5 degrees Celsius. It suggests that there is.

topic:

Source: www.newscientist.com

Understanding the Purpose of Designing Cars to Exceed Speed Limits

Why are cars designed to go far above the speed limit? (Don’t tell me they’re built with the Autobahn in mind.) Andy Crosby, North Wales

Please send new questions to nq@theguardian.com.

Reader replies

Because for mechanical reasons, a car that can get to 100 will perform better at 70 than a car that can only get to 70. Also, an engine that can only reach 110 mph on flat ground may struggle on hills. I was riding a 1.2 Clio and had to anticipate the hills and lower gears so I wouldn’t run out of breath. My Golf Diesel ran smoothly on the same slope without any complaints. Of course, you can also install a speed limiter on your vehicle (I often drive minibuses with speed limits). But consider the problems that arise when a speed-limited truck tries to pass another truck, slowly weaving in the center lane of a freeway, and the resulting confusion and congestion. yorkshire expatriate

I think the Germans call this the “elephant race”. socialism now

Of course, men are embarrassed to buy Viagra. Greg KZ

Is it because you are selling it? Automotive journalists like to include acceleration and top speed performance as positive in their reviews. So perhaps car buyers want a faster car, even if they can’t use that performance (at least in theory). reggie pudding

I purchased a 2015 Audi A5 3.0TDi Quattro 5 years ago. With 245bhp it will reach 60mph in less than 6 seconds. When you need that oomph to pass a bloke going 40mph on the local highway, it’s also thanks to its bags of torque that it means overtaking is quick and easy.

Top speed is limited to 155 mph, but I’ve never seen one. In France, I hit 132 mph on the motorway, the legal maximum speed.

The best part is that despite the engine’s size, it literally ticks along at 110mph at 1,600rpm and gets over 50mpg on long trips. So it’s a good grand tourer, with the ability to drift, a decent slug of power, and the ability to growl when needed. This is called being flexible. I’m already looking forward to my next road trip to France! Chilled Gibo

You’re Jeremy Clarkson, I charge you £5! Tatty Bogle

I am disappointed that the transition to electric power is not seen as an opportunity to end our obsession with increasingly high-powered cars. We see advertisements boasting extraordinary acceleration rates and high power outputs, but as a result, batteries are increasingly required to be larger and heavier, and have a greater environmental impact during manufacturing and use. This is contrary to the potential of electric vehicles to reduce the impact of personal mobility. We will properly lower speed limits and introduce aggressive punitive taxes on large, powerful personal vehicles. evan 1

Highest efficiency point. Designed for 110 miles per hour, it runs at full capacity. Imagine sprinting endlessly on every trip. It is designed to have a top speed of 160 mph and then cruise at 110 mph. I can run comfortably. Seno j1

A significant number of EVs buck this trend by having very fast acceleration but relatively low top speeds. For example, in my case he is supposed to reach 60 in less than 7 seconds, and this acceleration corresponds to a top speed of 130-140. In fact, its top speed is around 108, more than enough to allow a comfortable margin of stress relief at legal speeds. It is also true that some EVs reach 60 points within his 3 seconds, which begs the question of how many drivers can handle this without crashing into a more solid vehicle. suspicious solipsist

Fuel Efficiency – If a car can go 240 km/h while redlining in 5th, it will rev much lower and consume less fuel, potentially reaching 120 km/h. mcknight

Is it because speeding fines are a valuable source of income? eddie miscellaneous post

Margin of error (also known as safety). You have to turn occasionally (at legal speeds) to avoid accidents, and you always have to use mechanical devices that aren’t working at stress points, because it’s not good for wheels to fall off. Speedy 95060

A car with an engine with a “design” speed of 130 mph can have a “smaller” carburetor fitted to the engine, which will limit power and speed accordingly, but with less impact on the engine and moving parts. It has the advantage of being less stressful. . Of course, this will be about the same price as the “unlimited” version, so boy racers will want to go over the speed limit, so I guess manufacturers choose the faster version to increase sales. balance and reason

Cars are sold as toys, but only incidentally as a means of transportation. Lochaber 1

I hope this is the answer they give as their “last word.” Doralicious

Source: www.theguardian.com