Study Reveals Chemicals Permanently Change DNA in Unhatched Ducklings

According to a researcher, thousands of synthetic chemicals could be disrupting the genetic makeup of birds before they hatch, as highlighted in recent research on ducklings.

Scientists from the Norwegian University of Science and Technology (NTNU) injected small doses of per- and polyfluoroalkyl substances (PFAS) into mallard duck eggs to investigate their effects.

The findings revealed that these chemicals could alter the ducklings’ DNA, switching genes on and off in various organs, ultimately reducing their chances of survival.

PFAS, often referred to as “forever chemicals,” are a category of synthetic substances that are notably resistant to environmental degradation.

In this experiment, researchers injected three different persistent chemicals into the duck eggs to evaluate their impacts. The eggs were then sealed in wax and incubated until they hatched.

Although the study was conducted in a controlled lab setting, the aim was to replicate the type of exposure these eggs might naturally receive from their mothers.

Immediately after hatching, scientists collected samples from the ducklings’ livers, hearts, and a unique organ known as the bursa of Fabricius, which plays a crucial role in the immune system.

Mother ducks exposed to PFAS in their environment can transfer the contamination to their offspring through their eggs – Credit: Getty Images

Results indicated that in the liver, two of the three persistent chemicals triggered genetic modifications in the ducklings, affecting genes related to fat metabolism.

The study’s lead author, En Fleur Brand, emphasized, “Mallards need to regulate fat storage and consumption precisely during both breeding and migration seasons.”

“Alterations in fat metabolism may hinder survival or reproductive success.”

Meanwhile, scientists were surprised to find no significant changes in the hearts of the ducklings, although bursa of Fabricius showed effects in all PFAS-exposed individuals.

Brand remarked, “We observed increased activity in genes typically involved in viral infection detection. However, the implications for the birds remain unclear.”

The researchers concluded that PFAS could be detrimental to young wildlife, such as ducklings, and advocated for stricter regulations on these chemicals.

While some PFAS have been permanently banned, thousands remain in use, and their impacts on animals, humans, and the environment are still not completely understood.

In their study, scientists assessed one widely regulated or banned permanent chemical, applicable in the European Union, the United Kingdom, and the United States, along with two others still in circulation.

Brand stated, “These substances are prevalent in a multitude of products, ranging from frying pans and waterproof clothing to fire extinguishers, food packaging, and antifouling coatings.”

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Source: www.sciencefocus.com

Revolutionary Single Treatment May Permanently Eliminate High Cholesterol

Cholesterol management may be achievable by altering just one switch in an individual’s genetic code—potentially for a lifetime.

A pilot study featured in the New England Journal of Medicine demonstrated a novel gene therapy that decreased patients’ low-density lipoprotein (LDL) cholesterol, commonly known as “bad” cholesterol, by nearly 50%, while also reducing triglycerides by an average of 55%.

If forthcoming trials yield similar results, this one-time therapy could serve as an alternative to the combination of medications that millions currently rely on to manage their cholesterol.

LDL cholesterol and triglycerides are lipids produced by the liver; however, excessive accumulation in the bloodstream can lead to fat deposits that may result in cardiovascular diseases, which account for about one-third of deaths in the United States.

“Both LDL cholesterol and triglycerides are linked to severe cardiovascular risks, such as heart attacks, strokes, and mortality,” remarked Steven Nissen, a professor of medicine at the Cleveland Clinic Lerner School of Medicine. BBC Science Focus.

Nissen was part of a research team focusing on lowering cholesterol levels by targeting the ANGPTL3 gene, associated with LDL cholesterol and triglycerides.

About 1 in 250 individuals possess a mutation that deactivates this gene, leading to lower lipid levels in their blood. Nissen noted, “Importantly, the occurrence of cardiovascular diseases in these individuals is also minimal.”

Thanks to CRISPR gene-editing technology, identifying individuals who might benefit from this mutation is no longer just a matter of chance.

CRISPR selectively modifies DNA by targeting specific genes. – Credit: Getty

Utilizing CRISPR, Nissen and his team developed a treatment to deactivate the ANGPTL3 gene in the liver, which was then infused into 15 patients during an initial safety study.

The treatment significantly reduced participants’ LDL and triglyceride levels within two weeks, and these reductions remained stable after 60 days. Nissen stated, “These changes are anticipated to be permanent.”

Healthcare professionals recommend maintaining LDL cholesterol levels below 100mg/dL to promote heart health. While lifestyle changes can assist, many individuals, particularly those with genetic tendencies to high cholesterol, find it challenging to reach this target.

While existing medications are effective, no drugs simultaneously lower both LDL cholesterol and triglycerides, often requiring patients to take multiple medications daily for life to manage their cholesterol.

“The next phase of the trial is set to commence in the coming months, involving more patients with elevated LDL cholesterol or triglycerides,” Nissen stated.

If the trials continue to succeed, this therapy could serve as a lasting solution against some of the most significant health threats globally.

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Source: www.sciencefocus.com