Neuroscientist Advocates for Greater Kindness Towards Individuals with Mental Illness

When you think of a psychopath, you might envision a dangerous individual whose ruthless self-interest harms others while benefiting themselves. Surprisingly, psychopathy is more prevalent than most realize; approximately 1 percent of the general population exhibits psychopathic traits, equating to about 1 in 5 men. This is evident in both prison populations and links to corporate leadership where psychopathic traits can often be found.

While interacting with a psychopath can be distressing, living with psychopathy is equally challenging. According to Abigail Marsh, a psychology and neuroscience professor at Georgetown University, many individuals with psychopathic traits lead ordinary lives—but are often reluctant to embrace those traits.

Though the exact definition of psychopathy remains under study, it is generally characterized by traits such as insensitivity, lack of empathy, charismatic charm, and impulsivity. Screening tools often assess behaviors including pathological lying, grandiosity, manipulative tendencies, and a constant need for stimulation.

Research has shown that psychopaths may focus excessively on their own goals, failing to understand other perspectives. A study led by scientists, including Marsh, found that structurally, the brains of those with psychopathy differ significantly.

Marsh’s research examines individuals with high psychopathy scores from the general population rather than from prisons. In a groundbreaking study published last year, her team quantitatively measured how individuals with psychopathic traits perceive the well-being of others. She shared insights with New Scientist about these surprising findings and the nuances of psychopathy in relation to compassion.

Sabrina Weiss: How do psychopaths experience life?
Abigail Marsh: Generally, they report an inability to feel strong emotions such as fear, guilt, remorse, or love. While some may believe life would be simpler without these feelings, it often leads to greater challenges. Many individuals spend their lives concealing their true selves for various reasons—either to manipulate or to facilitate social interaction.

There is significant stigma surrounding psychopathy, often regarded as a permanent moral failing rather than a mental disorder rooted in genetics and life experiences. Understanding that psychopathy stems from treatable biological processes is crucial.

What do we know about the brains of psychopaths?
Although diagnosing psychopathy through brain scans alone is impossible, research has highlighted consistent differences. One notable difference is found in the amygdala, which tends to be smaller in individuals with psychopathy. Studies show that individuals with smaller amygdalae often exhibit more severe psychopathic traits over time, and these brain regions show reduced responsiveness to social cues indicating fear or danger.

Additionally, researchers have noted anatomical or functional variations in other brain areas, including the striatum, which influences our responses to potential rewards, and other regions in the prefrontal cortex, which are critical for decision-making and behavioral regulation.

Wolf of Wall Street: Notable characters with psychopathic traits.

Photo 12/Alamy

How can mental illness be treated?
Research indicates that years of therapy can assist individuals with psychopathy in managing their symptoms. However, accessible public health resources tailored for personality disorders, particularly those involving antisocial behaviors, are scarce. Society often neglects the needs of psychopaths, which is tragic, as these individuals deserve appropriate care akin to those with other mental disorders. It’s vital to recognize that some people actively seek out improvement methods.

Can a psychopath change?
Some individuals report using strategies like behavior modification to foster long-term changes. For instance, one person shared that by “faking it” as a good individual, he gradually developed a genuine sense of empathy. Clinical psychologists often advocate for practicing desired behaviors until they become habitual, which reflects the experiences shared by those striving for self-improvement amidst their psychopathic traits.

What moral codes do they develop?
An interesting case involved someone with aggressive tendencies who decided to channel those impulses towards social justice causes. He would confront people making offensive comments, but generally managed to control his actions through the personal principles he established.

How common is the desire for change among psychopaths?
While quantifying this interest is challenging, many interviewees expressed dissatisfaction with their lives and recognized their destructive behaviors. Although they desire change, they often grapple with a lack of effective remedies.

It’s significant to note that individuals contacted us after screening tests on our organization’s website; thus, we have preliminary insights into their perceptions. Research across various neurological and personality disorders indicates that many individuals may lack awareness of their conditions, a phenomenon referred to as agnosia.

Why avoid using the term “psychopath”? Referring to individuals as “mentally insane”?
Evolving clinical psychology seeks to adopt a more person-centered approach that refrains from labeling individuals by their disorders. Today, we prefer to describe people as having depression or schizophrenia instead of defining them solely by these conditions. Sadly, this perspective has not permeated societal views on personality disorders, where terms like “psychopath” or “narcissist” remain prevalent.

What motivated you to study psychopathy?
My journey began with a fascination about what drives people to care for one another. Part of my research involves highly altruistic individuals. A personal experience—a stranger helping me after a serious car accident—shaped my perspective on humanity.

However, a subsequent negative experience—being assaulted by a stranger—testified to the darker side of human behavior, igniting my curiosity about psychopathy and its implications.

Beyond screening tests, how do you recruit participants for your research?
My latest study successfully engaged over 700 individuals, including 288 with significant psychopathy scores from the Aggressive Disorder Prevention Association. Those scoring highly are invited to participate through website pop-ups.

In lab-based studies, we employ flyers with engaging phrases to attract participants, akin to an advertising campaign from the 1970s aimed at recruiting individuals with psychopathy.

In your recent study, you assessed how individuals with psychopathic traits evaluate the well-being of others. Why is this significant?
Antisocial behavior often derives from self-serving motives at the expense of others. Common forms include theft and dangerous driving. While most people may evaluate rewards based on proximity, those exhibiting psychopathy demonstrate a drastic valuation drop regarding strangers’ welfare compared to their own.

Individuals with psychopathy often engage in risky behaviors, such as stealing.

Jaco Brand/Getty Images

Were there any surprising results?
The findings were even more pronounced than anticipated. Our “social discounting task” evaluated how individuals value rewards based on their recipients. Most people don’t significantly reduce the value of a reward when a close one receives it. However, among participants with psychopathy, I observed an alarming rapid decline in the value they assigned to others’ welfare.

How does psychopathy impact daily life?
Many of us may unknowingly interact with individuals exhibiting psychopathic traits. Given that about 1 in 100 people are estimated to have clinically meaningful psychopathic traits, it is plausible that someone in your circle could be harmful or manipulative without being recognized as a threat.

What should you do if you suspect someone has a mental disorder?
It’s crucial to understand that psychopathy is indeed a genuine mental illness that can be effectively treated. Individuals with psychopathy often experience detrimental impacts on their health, relationships, employment, and overall quality of life. However, through knowledgeable therapy, behavioral improvements are achievable. For resources and information, individuals can visit the Aggressive Disorder Association website.

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Source: www.newscientist.com

Exploring the Impact of Illness on Our Lives: A Captivating Yet Imperfect Read

Healthcare professionals in protective masks stand near a triage tent for possible COVID-19 patients outside Santa María Hospital in Lisbon on April 2, 2020. Over 500 lives have been claimed by COVID-19 in Portugal, with more than 6,000 confirmed cases. (Photo by PATRICIA DE MELO MOREIRA/AFP via Getty Images)

Healthcare professionals stand near a COVID-19 triage tent in Lisbon, Portugal, April 2020.

Patricia de Melo Moreira/AFP via Getty Images

The Great Shadow
by Susan Wise Bauer, St. Martin’s Press

Publishing a book on the history of disease seems timely given the ongoing challenges with public health. As we face yet another tough winter in the Northern Hemisphere, we reflect on the previous harsh winter during the COVID-19 pandemic. Our vulnerability to illness has never been more evident.

Introducing The Great Shadow: A History of How Disease Shapes Our Actions, Thoughts, Beliefs, and Purchases, authored by Susan Wise Bauer. This work chronicles how disease influences individual lives and collective societal behaviors over centuries. From our guilty pleasures to our shopping habits, microbial influences are always at play.

However, the subject isn’t entirely new; similar works have emerged since the pandemic, such as Jonathan Kennedy’s comprehensive essays, along with updated versions of Sean Martin’s A Short History of Disease and Frederick F. Cartwright and Michael Biddis’s Disease and History. So, what sets this work apart?

The distinction lies in Bauer’s emphasis. She explores the shift from the “Hippocratic universe” to our contemporary understanding steeped in “germ theory.” The former relies on antiquated beliefs regarding bodily humors and inner balance, while the latter focuses on scientific evidence.

A key revelation of this book is the prolonged timeline for this transition; the acknowledgment that microbes cause disease took centuries to establish and only gained traction in the late Victorian era—resulting in millions of unnecessary deaths.

Yet, have we completely moved past Hippocratic medicine? The Great Shadow doubles as a discussion piece. Each chapter unveils a timeline, navigating through urbanization, the Black Death, and the trenches of World War I, before linking historical events to current beliefs surrounding disease.

At its best, this research provokes contemplation. Are we surprised that 19th-century anti-vaccination advocates resemble today’s skeptics? At its worst, some discussions may prove perplexing. For instance, Bauer confesses that following COVID-19, she avoided checkups out of fear of being criticized for her weight gain—a worrying reflection on the pressures surrounding health discussions.

Nevertheless, glimmers of insight are present in The Great Shadow. Despite moments of verbose writing, Bauer efficiently crafts narratives from historical archives. Her account of early germ theory proponents like Alexander Gordon and Ignace Semmelweis, often marginalized for their views, merits cinematic adaptation.

The final, memorable aspect of this book discusses our shift from superstition to science, presenting the current crisis termed the Third Epidemiological Transition. Bauer notes that we face not only epidemic failures with antibiotics but also the rapid emergence of novel diseases for which vaccines and treatments are yet unavailable, facilitated by modern global travel.

Peter Hoskin is the Books and Culture Editor at Prospect magazine.

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Source: www.newscientist.com

How AI is Set to Revolutionize Mental Illness Diagnosis

Vibrant chatbot icon representing AI in mental health

The most significant advancements in depression treatment have not occurred since the 1980s. Prozac, the first SSRI (Selective Serotonin Reuptake Inhibitor), marked a pivotal moment when it was introduced. This medication quickly spread globally, leading to hundreds of millions of individuals relying on SSRIs. Despite three-quarters of users reporting positive effects, not everyone experiences success with these treatments. As rates of depression continue to rise and with no substantial breakthroughs in therapies since SSRIs, an increasing number of people hope AI could revolutionize psychiatric care.

However, concerns remain. The effectiveness of chatbots hinges on the quality of data used for training. These AI tools are also susceptible to inherent biases and errors, often referred to as “hallucinations.” A recent study revealed that many well-known AI models fell short in providing reliable advice for 60% of women’s health inquiries.

Yet, AI could offer much-needed objectivity in the challenging realm of mental health diagnosis. Currently, depression diagnoses rely on ambiguous symptoms. By harnessing AI’s ability to analyze minor physical indicators, such as facial expressions and vocal patterns, psychiatry is on the path to establishing clearer biomarkers urgently needed in the field.


AI can finally impart the objectivity needed to tackle the challenging nature of diagnosis.

The consequences of inadequate treatment are profound. In the absence of novel biomarkers, recent studies have highlighted the crucial influences of relationships and exposure to nature in the prevention of depression. Notably, a recent review provided compelling evidence that physical exercise can be as effective as antidepressants and cognitive behavioral therapy in treating depression, although the reasons and ideal candidates for this approach remain unclear.

If AI can effectively determine which treatments suit individuals best, it may transform the lives of millions. Developers can learn to mitigate the numerous pitfalls associated with AI from the outset, ensuring that no patient encounters a “hallucinating” psychiatrist in the process.

Source: www.newscientist.com

DNA Uncovers the Illness that Plagued Napoleon’s Defeated Army

As Napoleon advanced into Russia in 1812, he commanded the largest army ever assembled in Europe. However, his return was marked not by gunfire, but by the chilling impact of microscopic foes.

Scientists examining DNA from the teeth of soldiers who perished during the retreat from Moscow have uncovered two diseases that devastated the Tsar’s grand army.

Historically, “typhus has been regarded as the most widespread illness in the military,” stated Nicolas Raskovan, director of the microbial paleogenomics department at the Pasteur Institute and lead author of the research. The findings were published in “Current Biology”.

Employing a method known as shotgun sequencing, Raskovan and his team investigated ancient DNA from the dental remains of 13 soldiers discovered near Vilnius, Lithuania, and identified two “previously undocumented pathogens.”

“We have confirmed the presence of Salmonella enterica, which is part of the Paratyphoid C strain,” he explained to NBC News, noting this bacteria is responsible for paratyphoid fever, along with Borrelia ricerentis, the agent of relapsing fever.

These diseases would likely have thrived in environments where “sanitation and hygiene were severely lacking,” he added.

The results align with historical accounts detailing symptoms like fever and diarrhea that plagued Napoleon’s troops, according to the study.

A “reasonable scenario” for the fatalities might include “extreme fatigue, cold weather, and multiple illnesses, such as paratyphoid fever or louse-borne relapsing fever,” the researchers noted.

“Although not necessarily deadly, louse-borne relapsing fever can be profoundly debilitating for someone already worn down,” they added.

In contrast to a 2006 study that discovered traces of bacteria causing typhus and trench fever in four out of 35 individuals, this research found no evidence of those illnesses.

However, Raskovan noted that while early research was constrained by the technology at the time, both old and new findings paint a clearer picture of the factors that led to the downfall of Napoleon’s forces.

“The discovery of four different pathogens in such a significant number of individuals strongly indicates that a variety of infections were widespread,” he remarked.

Approximately 300,000 lives were lost before Napoleon’s army retreated. It appears even an emperor cannot conquer the realm of microorganisms.

Source: www.nbcnews.com

Exploring a Unique XR Experience on Mental Illness in Melbourne’s Abandoned Mall

I recently explored Footscray, located just outside central Melbourne, and last week, I perceived it in an entirely new way. As a surreal, nightmarish realm, it’s unlike any ordinary reality. The idea of rejuvenating areas through art isn’t new, yet it’s captured in the profound dimensions of the door in question, characterized by intense, sometimes precariously unstable augmented reality, and productions that merge XR, immersive theatre, escape rooms, virtual reality, and mixed reality.

Creator and director Troy Rainbow labeled the door an “immersive journey into mental illness,” drawing from both his own experiences and those of his mother, who dealt with schizophrenia.


At 37, Rainbow utilized a letter he had penned to his mother, reflecting “her style of thought and the mindset I found myself in,” which shaped the central challenge of “adapting a paranoid belief system into the narrative.” The storyline features four delusional characters, each convinced that a man named Anton met his demise in a unique manner.

The term “immersive” has been thrown around frequently, yet this doorway truly embodies it, crafting an all-encompassing experience that captivates every sense—sight, touch, and even smell.

The experience unfolds within and around Footscray’s largely vacant Metro West Shopping Centre. Photo: Lauren Maa

The journey kicks off in a small room at the Metro West Shopping Centre, which Rainbow describes as filled with “lost dreams.” After a short guided meditation, I donned a VR headset, stepping out of that room to virtually navigate through the transformed center, discovering unique objects that hadn’t existed before. Some will later revisit these in physical form, blurring the lines between reality and illusion, triggering an uncanny sense of déjà vu.

Exchanging my headset for headphones, I ventured outside where a mysterious woman narrated stories related to the various locations around me.

Participants traverse a series of surreal outdoor rooms filled with dilapidated and decaying elements. One area resembles a lab, featuring dental chairs, while another is a security room where one can converse with an AI that mimics their voice. An unkempt kitchen is scattered with broken and oddly arranged objects, and a disquieting children’s room is filled with beautiful snakes and makeshift board games strewn across the bed.

Participants navigate through a multitude of surreal rooms throughout their adventure. Photo: Lauren Maa

The experience unfolds with voices emerging from unexpected corners, some activated by directional speakers. “It genuinely sounds like the thoughts in my head,” remarks Rainbow. These voices deliver peculiar and at times frenzied rants—one man discusses our souls transitioning into data, while a child marvels at God’s miracles. As you navigate these settings, you encounter unusual photographs and written materials, including religious texts, handwritten notes on the walls, and documents tucked into folders. It feels reminiscent of stepping into horror films or video games.


The door in question (which debuted in 2021 and has undergone several iterations since) resonates powerfully due to its intimate format. Throughout the experience, participants find themselves alone—with the exception of actors offering guidance—and left with their inner thoughts (and all the wild ideas bouncing off the walls). This intimacy, coupled with the participant’s role as co-author, renders the experience profoundly personal.

This approach to storytelling diverges significantly from traditional media, such as films and live theatre, with their fixed representational frameworks. Beyond the stark differences in dialogue, this form of storytelling uses space to unveil information and facilitate interactions between narratives and locations.

Troy Rainbow’s creations draw from personal letters and writings of his mother, who faced schizophrenia. Photo: Lauren Maa

Tech plays a crucial role in this endeavor, with Rainbow asserting, “I see technology as more than just a tool; it’s a co-creator.”

Selecting the appropriate real-world setting is equally vital, as utilizing abandoned, deteriorating spaces allows Rainbow to explore the question, “What does this inform the experience?” He adds, “Imagine how thrilling it would be if a more artistic endeavor was embedded within dormant spaces.”

Source: www.theguardian.com

Kennedy embarks on tour despite ongoing battle with chronic illness

Health Secretary Robert F. Kennedy Jr. will embark on a tour of the Southwest on Monday, focusing on nutrition and lifestyle choices as tools to combat disease. This tour, known as the Make America Healthy Tour, will take Kennedy through parts of Utah, Arizona, and New Mexico. The opening day of the tour is expected to be controversial.

Questions about the federal government’s response to the measles outbreak in West Texas have been raised, with the recent death of an unvaccinated child adding to the concerns. Kennedy attended the child’s funeral before continuing to Utah.

During the three-day tour, Kennedy’s staff plans to visit multiple health centers, a medical school teaching kitchen, meet with Navajo leaders, and visit a charter school in New Mexico to promote healthy lifestyles for students.

Since taking office, Health Secretary Robert F. Kennedy Jr.’s policies have stirred controversy, particularly his stance on vaccinations. His recent public statements indicate a shift towards supporting vaccines as an effective way to prevent diseases like measles.

While some public health experts remain skeptical of Kennedy’s position on vaccines, he plans to address the issue during a press conference in Salt Lake City. Kennedy will also discuss the importance of removing fluoride from drinking water, a topic he has advocated for in the past.

Kennedy’s views on vaccination and fluoridation have generated debate, but his tour aims to raise awareness about the role of nutrition and lifestyle in preventing diseases like measles. The tour is a platform for Kennedy to promote health initiatives and engage with communities in the Southwest.

Healthy foods and exercise play a role in limiting the outcomes of infectious diseases, but vaccination remains the best preventive measure. Dr. Michael Mina emphasizes the importance of vaccination in preventing measles infections.

Kennedy’s tour will address the importance of preventive measures like vaccination, while also focusing on issues like fluorination of drinking water. The debate around fluoridation has a long history, with conflicting views on its benefits and potential risks.

As Kennedy continues his tour of the Southwest, he will explore the intersection of nutrition, lifestyle choices, and public health initiatives. His approach to promoting health and wellness reflects a broader conversation about disease prevention and community well-being.

Source: www.nytimes.com