New Research Identifies Additional Dog Breeds at Elevated Risk for Respiratory Diseases

Pekingese and Japanese Chin Dogs

Pekingese and Japanese Chin dogs are at an increased risk for respiratory diseases.

Michael Schultze, Catamount/Alamy

Dog owners are urged to consider a broader spectrum of breeds when seeking a puppy, as recent studies indicate that serious breathing issues are more common than once believed.

Brachycephalic breeds—dogs with short snouts and flat faces—have surged in popularity, according to Francesca Tomlinson from Cambridge University.

However, along with their rising popularity, these breeds face increasing health concerns, primarily Brachycephalic Obstructive Airway Syndrome (BOAS), which can present as noisy or labored breathing. This condition severely hampers activities like exercise, sleep, and managing heat and stress.

While concerns about BOAS frequently focus on breeds like English bulldogs, French bulldogs, and pugs, research led by Tomlinson explored 898 dogs from 14 breeds including the Affenpinscher, Boston Terrier, Boxer, and Pekingese.

All subjects underwent comprehensive respiratory evaluations and detailed body and facial measurements.


Findings revealed that Pekingese and similar breeds are exceptionally vulnerable to BOAS, with over 80% affected. Breeds like the Cavalier King Charles Spaniel, Shih Tzu, and others showed moderate risk, while only the Maltese and Pomeranian showed no significant health concerns.

Three major factors contribute to breathing issues: excess weight, narrow nostrils, and extreme facial flattening. Other traits, such as short or screw-shaped tails, may also be linked to BOAS-related anatomical changes. “It’s not solely flatness that influences risk; various factors play a role,” explains Tomlinson.

Prospective dog owners should seek puppies from health-tested parents and familiarize themselves with the potential health consequences of extreme physical traits, particularly those affecting the face.

“Our goal isn’t to eliminate defining breed characteristics but to support breeding that promotes function over mere appearance,” Tomlinson emphasizes.

She adds that the severity of physical trait exaggeration is crucial in determining health outcomes. “This suggests a practical approach: opting for less extreme physical traits may help lower disease risk.”

Anna Quine from the University of Sydney highlights that “cute” flat-faced dogs are more susceptible to chronic respiratory distress and heat stress.

Breeding dogs for a flat face is akin to “designing a car without a radiator,” she warns. “If we’re introducing dogs into the world, our first priority should be their welfare, not merely satisfying human aesthetic preferences.”

Paul McGreevey, also from the University of Sydney, concurs that the study validates what many veterinarians already suspect: compromised airways are common in flat-faced dogs, with variations across and within breeds.

“For dogs struggling with airway issues and carbon dioxide expulsion, breed labels become irrelevant,” he states, noting that classifications are human decisions.

Yet, he raises concerns regarding the study’s methodology, pointing out the subjective nature of classifying respiratory sounds. “This raises questions about consistency across the 14 distinct breeds,” McGreevy states. “Moreover, the authors admit that athletic assessments depend on individual speed and temperament.”

Tomlinson countered that the evaluation incorporates objective measures, including abnormal breath sound detection, following a standardized protocol. “The intention of the exercise test is not to assess exercise capacity but to observe how airways react to mild exertion,” she clarifies.

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Source: www.newscientist.com

Introducing EBCare: A Revolutionary Smart Mask for Monitoring Metabolic and Respiratory Health

Recent respiratory disease epidemics have attracted a lot of attention, yet most respiratory monitoring is limited to physical signals. Exhaled breath condensate (EBC) is packed with rich molecular information that can reveal various insights into an individual's health. Now, Professor Wei Gao and colleagues at California Institute of Technology have developed EBCare, a mask-based device that monitors EBC biomarkers in real time. For example, the EBCare mask can monitor asthma patients for their levels of nitrite, a chemical that indicates airway inflammation.

This diagram shows how the smart mask detects breathed chemicals, such as nitrite, an indicator of airway inflammation. Images by Wei Gao and Wenzheng Heng, Caltech.

“Monitoring a patient's breathing is routinely done, for example to assess asthma and other respiratory diseases,” Prof Gao said.

“However, this method requires patients to visit a clinic to have a sample taken and then wait for the test results.”

“Since COVID-19, people have started wearing masks. We can leverage this increased use of masks for remote, personalized monitoring to get real-time feedback on one's health from the comfort of one's own home or office.”

“For example, we could use this information to evaluate how effective a medical treatment is.”

To selectively analyze the chemicals and molecules in your breath, you first need to cool them down and condense them into a liquid.

In a clinical setting, this cooling step is separate from the analysis: Moistbreath samples are cooled in a bucket of ice or a large refrigerated cooler.

The EBCare mask, on the other hand, is self-cooling, according to the team.

The breath is cooled by a passive cooling system that integrates hydrogel evaporative cooling and radiative cooling to effectively cool the breath on the facemask.

“This mask represents a new paradigm for respiratory and metabolic disease management and precision medicine because wearing it daily allows for easy collection of breath samples and real-time analysis of exhaled chemical molecules,” said Wen-zheng Heng, a graduate student at the California Institute of Technology.

“Breath condensate contains soluble gases as well as non-volatile substances in the form of aerosols and droplets, including metabolic products, inflammatory indicators and pathogens.”

Once the breath is converted into liquid, a series of capillaries in a device called bioinspired microfluidics immediately transports the liquid to a sensor for analysis.

“We learned how to transport water from plants, which use capillary action to pull water up from the ground,” Professor Gao said.

“The analysis results are then sent wirelessly to an individual's phone, tablet or computer.”

“The smart mask can be prepared at a relatively low cost. The materials are designed to cost just $1.”

To test the masks, the authors conducted a series of human studies, focusing primarily on patients with asthma or COPD.

The researchers specifically monitored the patients' breath for nitrite, a biomarker of inflammation in both diseases.

Results showed that the masks accurately detected biomarkers indicative of inflammation in patients' airways.

In a separate experiment, the masks demonstrated that they could accurately detect subjects' blood alcohol levels, suggesting that they could potentially be used for field DUI checks and other alcohol consumption monitoring.

We also explored how the mask can be used to assess blood urea levels in the monitoring and management of kidney disease.

As kidney function declines, by-products of protein metabolism, such as urea, accumulate in the blood.

At the same time, the amount of urea in saliva increases, which breaks down into ammonia gas, leading to high ammonium concentrations in the breath condensate.

The study showed that the smart mask could accurately detect ammonium levels, closely reflecting the urea concentration in blood.

“Our smart mask platform for EBC collection and analysis represents a major advancement in the potential for real-time monitoring of lung health,” said Professor Harry Rossiter, director of the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center.

“This concept, with the potential to add biosensors for a wide range of compounds in the future, highlights the groundbreaking potential of smart masks in health monitoring and diagnostics.”

The team's work is paper In the journal Science.

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Wen-zhen Heng others2024. Smart masks for collection and analysis of exhaled breath condensate. Science 385 (6712): 954-961; doi: 10.1126/science.adn6471

This article is a version of a press release provided by Caltech.

Source: www.sci.news