Boosting Vitamin D in Midlife Linked to Reduced Alzheimer’s Disease Biomarkers Later

In a groundbreaking study, Dr. Martin David Mulligan from the University of Galway and his team investigated the long-term effects of vitamin D levels on brain health by following nearly 800 participants from the Framingham Heart Study for over 15 years. Their findings revealed that individuals with higher circulating levels of vitamin D at age 30 exhibited significantly less accumulation of tau protein—a key factor in the development of Alzheimer’s disease—when retested approximately 16 years later. This association remained robust even after accounting for various factors such as age, gender, cardiovascular health, smoking, depression, and BMI.

Vitamin D deficiency in midlife may be a modifiable risk factor for preclinical dementia signs observed in neuroimaging. Image credit: Aloysio Costa Latoje.

Dementia currently ranks as a leading cause of morbidity worldwide, impacting an estimated 57 million individuals.

“Our research indicates that maintaining high vitamin D levels during midlife may safeguard against the formation of tau deposits in the brain, while insufficient vitamin D could serve as a modifiable risk factor for dementia,” stated Dr. Mulligan.

“Further validation through additional studies is essential to confirm these results.”

The study analyzed data from 793 adults (53% female, average age 39 years) who were dementia-free at the time of brain imaging.

Blood levels of 25-hydroxyvitamin D were measured between 2002 and 2005, followed by positron emission tomography (PET) scans assessing tau and amyloid deposits conducted from 2016 to 2019.

Accumulation of tau protein, particularly in regions like the entorhinal cortex and temporal lobe, is known to play a crucial role in the early onset of Alzheimer’s disease.

Researchers observed that elevated vitamin D levels correlated with reduced tau levels throughout the brain and in these vulnerable areas.

“Notably, 34% of participants exhibited low vitamin D levels, and only 5% were taking vitamin D supplements,” the researchers reported.

This study contributes to the growing body of evidence correlating vitamin D with brain health, focusing specifically on early preclinical changes rather than solely on clinical outcomes like dementia diagnosis and aging.

Scientists propose that ensuring adequate vitamin D levels in midlife may serve as a proactive strategy to mitigate neurodegenerative changes before clinical symptoms manifest.

However, it is important to note that this study does not establish a direct causal relationship between vitamin D and the prevention of tau accumulation or dementia. The researchers measured vitamin D at a single time point without tracking its changes over the years, and they did not assess whether supplementation influenced brain health.

“These promising findings suggest a significant association between increased vitamin D levels in early midlife and decreased tau load 16 years later,” Dr. Mulligan remarked.

“Midlife is a critical phase where modifying risk factors could yield substantial benefits.”

For more information, refer to the published results in the journal Neurology.

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Martin David Mulligan et al. 2026. Association of circulating vitamin D in midlife with increased tau-PET burden in adults without dementia. Neurology 2 (2): e000057; doi: 10.1212/WN9.0000000000000057

Source: www.sci.news

Why Olive Oil is the Ultimate Choice for Boosting Brain Health

Olive Oil: A Key Ingredient in a Brain-Boosting Diet

Alexander Prokopenko/Shutterstock

Understanding the health benefits of olive oil is essential, as it not only lowers “bad cholesterol” but also combats inflammation and safeguards against chronic diseases, including various cancers. Recent studies indicate that its advantages may extend to brain health.

What does this mean for cognitive function? Is extra virgin olive oil really necessary, and how much should one consume for optimal benefits? The answers may be more encouraging than you think, as other oils may also support brain health.

It’s important to remember that nutrition research is complex and often unreliable. For instance, participants may struggle to accurately track their food intake, leading to unreliable data. However, some patterns emerge from observational studies, especially when experimental research reinforces these findings.

Olive oil is a fundamental component of the widely acclaimed Mediterranean diet, renowned for promoting health. This diet encourages the consumption of tomatoes, whole grains, fresh fish, and generous amounts of olive oil, occasionally paired with red wine. Numerous studies link this lifestyle to reduced rates of heart disease, type 2 diabetes, and even dementia.

The Mediterranean diet is particularly high in fats, primarily from olive oil, prompting scientists to investigate its specific role. According to nutrition specialist Richard Hoffman from the University of Hertfordshire, England, “The Mediterranean diet is significantly more effective when enhanced by extra virgin olive oil.”

A landmark study in Spain involved over 7,000 participants aged 55 to 80. One group ingested 1 liter of extra virgin olive oil weekly while adhering to a Mediterranean diet. Others either supplemented their meals with nuts or were advised to reduce fat intake.

After five years, participants in the olive oil group exhibited markedly lower instances of heart disease and stroke. Daily consumption of just 10 grams of olive oil correlated with a 10% reduction in cardiovascular disease risk and a 7% decrease in mortality.

Current consensus among scientists suggests that olive oil can mitigate inflammation and enhance cardiovascular health. But how does it affect the brain?

A large-scale study published in 2024 examined over 92,000 adults, evaluating their olive oil consumption every four years for around 30 years. Findings revealed that higher olive oil intake was linked to a lower risk of dementia-related mortality.

Even after accounting for variables like BMI, physical activity, smoking, socio-economic status, and overall diet, a connection remained between olive oil consumption and reduced dementia risk.

Further analysis showed benefits from substituting other fats with olive oil. According to Marta Guasch-Ferré from Harvard University, “Replacing butter or other animal fats with olive oil resulted in an 8-14% decrease in dementia-related mortality risk.”

The Mediterranean Diet: Lowering Disease Risks with Olive Oil

Imaging Ltd./NurPhoto (via Getty Images)

Olive oil’s protective properties for the brain are attributed to polyphenols, which are abundant in this oil. These bioactive compounds shield plants from stress and pests and may do the same for humans by scavenging free radicals, reducing inflammation, and preventing harmful oxidation of fats that can lead to strokes.

Additionally, polyphenols nourish gut microbes, interacting with the immune system to minimize inflammation. Chronic inflammation is a major contributor to significant health issues, including heart disease and dementia, with growing evidence linking Alzheimer’s disease to inflammation in various organs.

According to Guash-Ferré, “Evidence is accumulating to support that olive oil may alleviate Alzheimer’s and other neurodegenerative conditions.”

Which Olive Oil is the Best for You?

It’s essential to differentiate among olive oils. Extra virgin olive oil is the least processed, retaining the most polyphenols. In contrast, virgin olive oil is subjected to more processing, while standard variety is processed extensively, losing many health benefits.

Is the type of olive oil significant? Guasch-Ferré indicates that any olive oil consumption correlates with a lower risk of mortality. The mix of healthy unsaturated fats and beneficial bioactive compounds positions olive oil as a premier plant-based oil.

A recent study explored how different olive oils impacted the microbiome and cognitive health of seniors. It evaluated 656 individuals, revealing that those consuming virgin olive oil showed cognitive improvements. In contrast, participants using standard olive oil experienced cognitive decline. Interestingly, this was linked to changes in the gut microbiome, with specific bacteria mediating some effects.

While this research is preliminary and involved a short follow-up period, it emphasizes the connection between diet, gut health, and brain function.

So what should you take away? While standard olive oil offers some cardiovascular benefits due to its favorable fat profile, extra virgin olive oil provides additional protective compounds. The great news is that other vegetable oils, such as canola and safflower, also contain beneficial fats and moderate polyphenol levels. In substitution models, Guasch-Ferré’s team found no cognitive health drawbacks from these oils compared to animal fats.

“Other vegetable oils can also provide health benefits, especially as they are typically more affordable than olive oil,” she notes. However, further research is warranted for conclusive guidance.

Ultimately, select the highest quality extra virgin olive oil that fits your budget. Although if that’s not feasible, replacing animal fats with other vegetable oils is a beneficial step toward brain health. If you aim for premium quality, pay attention to storage; light reduces polyphenol levels over time, so choosing a dark bottle is advisable for optimum health advantages.

I’m willing to invest a little more in high-quality extra virgin olive oil, not only for its rich flavor but also for its profound brain-health benefits.

Topics:

  • Neuroscience /
  • Nutrition

Source: www.newscientist.com

Tax Relief and Carmen Sandiego: Boosting Australia’s Former Video Game Industry

The perception that video games lack seriousness fails to recognize the benefits they provide to gamers who often feel disconnected.

“During the Covid pandemic, I realized that games serve as a vital means for people to connect and maintain relationships.”

Ross Simmons, CEO of Big Ali Studios, a Melbourne-based game development firm, recalls Tony Abbott’s dismissal of the national broadband network in 2010 when he referred to it as merely “internet-based television, video entertainment, and gaming.”

Simmons asserts that the industry’s marginalization has not endured over time.

Data from the Interactive Games and Entertainment Association (IGEA) indicates that Australians invested $3.8 billion in video games in the past year. Although this sector remains smaller compared to major development countries like Canada, it is gradually evolving.

In 2023, the Australian government introduced the Digital Game Tax Offset (DGTO), enabling local developers to claim a 30% refundable income tax offset for creating or porting games in Australia. This policy is applicable to companies that spend a minimum of $500,000 on development in Australia, with a cap of $20 million per company.

Ron Curry, CEO of IGEA, reports that the Australian gaming industry employed approximately 1,300 individuals between 2020 and 2021.




Industry experts believe that the government’s tax offsets and rebates are drawing international developers and fostering local talent.
Photo: Assanka Brendon Ratnayake/Guardian

The Game Development sector in Australia now employs 2,465 full-time staff and generated $3399.1 million in revenue for the fiscal year 2023-24. “This reflects nearly a 100% rise in employment and an approximate 85% increase in revenue,” he notes.

“The DGTO has activated numerous avenues. Previously, Australia was one of the most expensive places to develop games and the only developed nation lacking rebates or offsets. We have corrected this to align ourselves with other developed nations.”

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Curry expresses confidence in the industry, indicating that government support, along with state and territorial grants, has signified Australia as a “healthy environment for operation,” fostering trust among investors, game publishers, and prospective employees.

Interstate Competition and Legacy Building

Serge Xebian, a partner at Playlight Consulting which advises gaming firms on financial matters, states that the offset has substantially benefited companies hiring in Australia, spurring momentum in the sector.

“International studios are increasingly aware of this, particularly those with existing ties to Australian vendors. Now, many are actively looking toward Australia. My clients’ suggestions are rapidly moving up the agenda.”

Xebian notes that while New South Wales was once a film haven, Victoria now stands out as a game development center, although competition is intensifying. Queensland offers a 15% rebate in addition to the federal benefits, with a threshold set at $250,000, while Victoria’s rebates range from 10% to 15%, based on investment level, with a $500,000 threshold.

“We are seeing many independent game studios relocating to Queensland,” observes Xebian.

French game developer Gameloft inaugurated a studio in Brisbane in 2014, responsible for reviving the famous character Carmen Sandiego on Netflix, Xbox, PlayStation, PC, and Nintendo Switch this year.

Manea Castett, head of the Brisbane studio, reminisces about playing Carmen Sandiego games with his father, describing the character’s persona as both thrilling and adventurous. He appreciates the opportunity to reimagine the game and provide players with a “fun twist” on Sandiego’s adventures.

Castett mentions that their Brisbane studio stands out within the company for its rapid growth, expanding from 55 staff two years ago to 217 today. He highlights their ability to develop two games simultaneously, enabling a more comprehensive approach to game design, technology, audio, quality assurance, and marketing.

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“Globally, the landscape is shifting… there remains significant revenue potential. The Australian video game industry is on the rise.”

Development challenges

Big Ali’s studio became the center of a controversy during the launch of Rugby League 26 in July when users reported game bugs, which included incorrect jersey numbers and server issues that hampered gameplay.

Simmons described the day patches were deployed to enhance the game as “very satisfying,” explaining that the near deadline for release aligned with the NRL season forced hasty changes.




Simmons noted that Big Ant Studio’s latest rugby title temporarily overwhelmed its online servers, achieving sales over six times their anticipations. Photo: Assanka Brendon Ratnayake/Guardian

“In the week prior to the release, we implemented 1,200 changes, many of which involved alterations due to sponsorships related to betting, alcohol, and other elements,” he explains, describing the challenges involved.

Logos of gambling and alcohol companies present on player jerseys in real life were removed from the game due to increasing concerns about promoting these products to underage audiences. Simmons believes that they underestimated the game’s demand on launch day, which sold six times their initial projections, causing server issues they eventually addressed.

Before the tax offsets were introduced, Big Ant had around 50 employees; now, with the growth fueled by these initiatives, they expanded to 147. Simmons states, “This enables us to compete globally.”

The tight job market, wherein game development skills are sought after across diverse sectors including artificial intelligence, further complicates their growth trajectory.

Curry notes that while the industry boasts transferable skills that participants take pride in, it must vie for talent. Ensuring safe jobs, competitive salaries, and an immigration framework that attracts skilled professionals will aid in recruitment, he adds.

“Integrating senior talent into the country serves as an accelerator for the people they mentor,” he remarks. “In Canada, you can bring developers into the country in as little as two weeks. We’ve witnessed instances of individuals taking over two years to enter Australia.”

“In a fast-paced industry, such delays are problematic.”




Source: www.theguardian.com

Nvidia CEO: US Chip Export Controls Misfire by Boosting China’s Progress

Jensen Huang, head of Nvidia, stated that US chip export controls are a “fail” during his remarks at the High-Tech Forum on Wednesday.

In an effort to limit China’s military advancements and maintain US dominance in the AI sector, successive US administrations have placed restrictions on the sale of advanced AI chips to China. However, Huang indicated at the Computex Tech forum in Taipei that these controls have inadvertently motivated Chinese developers.

“The local companies are exceptionally skilled and highly motivated, and export control has provided them with the momentum, energy, and governmental backing to speed up their progress,” Huang shared at the Computex Tech Show in Taipei.

“On the whole, I believe export control has been a failure.”



“It’s crucial to acknowledge that China boasts a dynamic technological ecosystem, with 50% of the world’s AI researchers, and excels in software development,” Huang emphasized.

Nvidia, known for its high-performance GPUs, faces challenges due to US chip export regulations. Huang mentioned on Wednesday that the company has incurred “billions of dollars” in losses, with its share of the AI chip market in China plummeting from nearly 95% to 50% since the Biden administration took office.

According to the Financial Times, Huang made an unannounced trip to Beijing last month.

This visit took place shortly after new US restrictions prohibited the shipment of Nvidia’s H20 Datacentre GPU to China.

The US government informed NVIDIA that the new regulations aim to mitigate the risk of the product being “used in Chinese supercomputers.”

Huang’s Beijing conference reportedly focused on the AI company’s latest chip design, as per the FT report.

Last week, the Trump administration rolled back certain existing controls on chip sales to China after several countries expressed that they were being excluded from the essential technologies required for AI development.

Nonetheless, they issued new guidelines for other nations, warning that utilizing high-tech AI semiconductors produced in China, especially chips from Huawei, could breach existing US export regulations.

In retaliation, China accused the United States of “misusing export controls to suppress and restrict China.” The Commerce Department stated on Wednesday that the warning exemplifies “unilateral bullying and protectionism, significantly jeopardizing the stability of the global semiconductor industry and supply chains.”

Moreover, it cautioned that organizations or individuals enforcing or supporting such actions might be violating Chinese law.

Source: www.theguardian.com

Boosting Innovation and Competition in SMEs through AI: Redefining Work for More Efficiency and Engagement

Kevin Fitzgerald, managing director of UK Employment Heroes, emphasizes the importance of managers in businesses. He mentions that technology has advanced greatly, especially in the past decade, allowing for the digitization of many administrative tasks. According to Fitzgerald, AI should not be seen as a vague or scary new technology, but rather as a practical way to streamline and automate time-consuming tasks, enabling employees to focus on more valuable and interesting work.

The Employment Hero Survey revealed that 52% of respondents found the platform improved organizational efficiency, with 42% reporting faster processes and 65% using less paper.

By using AI to handle tasks like onboarding and data entry, employees have more time to focus on important aspects like welcoming new recruits and integrating them into the team quickly. Fitzgerald also mentions how AI can help with tasks like organizing employment contracts and setting up new employees in payroll systems swiftly.

Integrating AI into the workplace aligns with the shift towards flexible and hybrid work practices. This approach not only helps manage time effectively but also boosts employee engagement and energy levels.

Using AI for tasks such as payroll and HR automation is part of a long-term trend in digital transformation. Small and medium-sized businesses can now access tools like the Employment Operating System for Employment Heroes, consolidating multiple functions onto one platform for efficiency and cost savings.

AI’s ability to automate routine tasks and handle complex data processing makes it an invaluable tool in enhancing productivity and job satisfaction. By freeing up time and minimizing distractions, employees can engage in deep work, leading to improved efficiency and overall satisfaction.

Fitzgerald emphasizes that AI is user-friendly and embedded in platforms like Employment Heroes, providing powerful tools for staff to enhance their work. Embracing AI not only accelerates productivity but also empowers employees to work smarter, fostering a positive work environment.

Rethink what is possible with Employment Hero and revolutionize the way you work.

Source: www.theguardian.com

Boosting Creativity and Resilience by Embracing Your Shadow Self | BBC Science Focus Magazine

When you search the hashtag “mental health” on TikTok, you’ll come across a plethora of videos discussing “shadow work.” These videos have collectively amassed over a billion views and contributed to the success of The Shadow Work Journal, written by former TikTok employee Kayla Shaheen.

Despite its peculiar nature, the shadow work trend is actually a modern interpretation of a concept introduced by Swiss psychiatrist Carl Jung in the mid-20th century.


Jung, a colleague of Sigmund Freud, shared Freud’s belief in the significance of the unconscious mind in human psychology. One of Jung’s theories about the unconscious posits that everyone has a “shadow” self – a part of us comprised of characteristics we fear or dislike. He referred to it as the “shadow” to signify its dark and undesirable nature that we can’t escape.

Jung suggested that our shadow self is revealed when we speak or act thoughtlessly, and it can also manifest in our dreams.

The purpose of shadow work is to delve deeper into understanding your shadow self, learn from it, and integrate it into your being. By doing so, you can feel more authentic and whole as your shadow is a genuine part of who you are. Jung argued that the shadow possesses valuable attributes like raw power and insight, which can enhance creativity, personal understanding, and resilience when expressed.

Shadow work involves introspective exercises to connect with your shadow. For instance, Shaheen recommends spending time in a quiet, dimly lit space, listening to your inner voice, and reflecting on the words that come to mind.

Visualization exercises are also common in shadow work, such as imagining two doors leading to your ideal self and your shadow self, and envisioning the experience of walking through each door.

While some therapists appreciate the increased interest in self-reflection, others are concerned that the portrayal of shadow work on social media lacks depth and may not fully capture Jungian psychology. Additionally, for individuals with traumatic backgrounds, reflective practices may trigger distressing emotions best addressed in a therapeutic setting.

For skeptics, Jung’s theory, like Freud’s, lacks empirical evidence and may potentially harm individuals by attributing distressing thoughts to a supposed part of themselves.

This article explores the question “What is shadow work, and can embracing your shadow self enhance mental health?” posed by Lina McBride from Norwich.

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Source: www.sciencefocus.com