Tag Archives: combat

‘UK Artists Unite to Combat AI Image Generation Software’

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Since the advent of Midjourney and other image generators, artists have been observing and wondering whether AI represents a major opportunity or an existential threat. Midjourney names 16,000 artists whose work is said to have been used to train its AI, including Bridget Riley, Damien Hirst, Rachel Whiteread, Tracey Emin, David Hockney, and Anish Kapoor. Now that the list has been revealed, the art world is calling to arms. For engineers.

British artists have contacted U.S. lawyers to discuss joining a class action lawsuit against Midjourney and other AI companies, other artists told a U.S. newspaper. observer They argued that they could bring legal action themselves in the UK.

“What we need to do is come together,” said Tim Flack, president of the Society of Photographers and an internationally acclaimed photographer whose name also appears on the list.

“Releasing this list of names to the public is a great opportunity for artists to come together and take on this issue. Personally, I am in favor of doing so.”

The 24-page list of names constitutes Exhibit J in a class action lawsuit filed by 10 American artists in California against Midjourney, Stability AI, Runway AI, and DeviantArt. “We’re seeing interest from artists around the world, including in the UK,” said Matthew Butterick, one of the artists’ lawyers.

Tech companies have until February 8 to respond to the complaint. Midjourney did not respond to requests for comment.




Bridget Riley and her painting Rajasthan (2012)
Photo: Nils Jorgensen/Rex Shutterstock

Source: www.theguardian.com

Harnessing Nature: Releasing Billions of Engineered Mosquitoes into the Wild to Combat Disease

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Dengue fever is currently endemic in 100 countries, putting half of the world’s population at risk. The threat has increased dramatically, with the number of dengue fever cases increasing tenfold between 2000 and 2019, and the number of cases hitting an all-time high in 2023.

Bangladesh, Peru and Burkina Faso have all seen record outbreaks in the past 12 months, while France, Italy and Spain have also reported cases of mosquito-borne dengue fever.

What’s causing this? Scientists say global warming is making space more hospitable to insects, and that climate change is fueling the rise in this mosquito-borne viral disease. As mosquitoes become more common, we expect the time to outbreak of dengue fever to shorten and the transmission season to lengthen.

This is a worrying situation.But that’s what the sponsoring team decided world mosquito program There is a possible solution. They suggest treating mosquitoes with bacteria that can prevent the development of viruses in the body.

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What are the symptoms of dengue fever?

There’s a good reason dengue fever has been labeled “breakbone fever.” 80% of cases are asymptomatic, but when symptoms develop, symptoms include high fever, muscle and joint pain, severe headache, pain behind the eyes, nausea, and vomiting.

Symptoms begin 4 to 10 days after infection and can last from 2 days to up to a week. DHF (severe dengue fever) manifests as severe abdominal pain, persistent vomiting, bleeding gums or nose, blood in the stool or vomit, pale, cold skin, and fatigue. Doctors can only alleviate these symptoms because antiviral drugs are not available.

How does dengue spread?

Dengue fever is spread through the bite of an infected female mosquito. Aedes aegypti, typically found in tropical and subtropical regions. Originating from the forests of West Africa, Aedes aegypti They spread around the world during the African slave trade and have continued to hitchhike as a means of human transportation ever since.

other Aedes Other species can also transmit dengue fever, although to a lesser extent. The highly invasive Asian tiger mosquito is the likely cause of dengue infections in Europe. Unlike malaria mosquitoes, which usually bite at night and can be prevented with insecticide-treated bed nets, dengue mosquitoes bite during the day and are very difficult to control.

Mosquitoes are now highly urbanized creatures, admirably adapted to coexist with humans, their preferred blood source. In cities, stagnant water is key to survival, providing spawning grounds and habitat for aquatic larval and pupal development. Mosquitoes breed in small puddles in garbage, used tires, and man-made containers such as flower pots. Thus, humans have been the main driving force behind the success of the dengue mosquito.

How can we fight the spread of infection?

Dengue prevention requires a multipronged attack on mosquitoes, with a focus on insecticide spraying. However, insecticide resistance is developing in mosquito populations around the world, threatening their effectiveness.

what else? Control strategies also include adaptations to eliminate breeding sites or prevent reproduction. Aedes aegypti Prevent spawning in stagnant water (remove debris that could trap water and install covers on water storage containers).

Bacterial toxins are also applied to bodies of water to kill mosquito larvae. These strategies are labor intensive because it is difficult to identify, treat, and eliminate all breeding sites. Therefore, new methods of mosquito control are desperately needed.

The World Mosquito Program (WMP) has devised a non-chemical and non-GMO-based approach for dengue control. Bacteria called Wolbachia which occurs naturally in many insect species; Aedes aegypti.

WMP was found to be “infected”. Aedes aegypti and Wolbachia Prevented the onset of dengue virus in adult women. From a logistical point of view, this method is self-sustaining. Wolbachia It can spread to wild populations because it infects eggs through mating.

WMP reports a significant decrease in dengue cases. Aedes aegypti carry Wolbachia has been released.given that Aedes aegypti Since Zika and Chikungunya viruses are also transmitted, WMP has developed a potential “three-for-one” method of disease control.

It’s no exaggeration to say that mosquitoes are the most hated insects, but despite their notoriety, only a handful of the 3,500 species of mosquitoes transmit disease. They are also important to the ecosystem.

Mosquitoes are a food source for fish, frogs, reptiles, bats, and birds, and they are also pollinators, as male insects suck nectar from flowers (only females drink blood). The WMP approach is species-specific and targeted only. Aedes aegyptiThis is in contrast to the “blunt force” approach with insecticides, which can affect insects other than the target.

The climate change trajectory we are currently on is leading to rising temperatures and changing rainfall patterns, which will benefit this terrifying little insect and her viral cargo. Therefore, we need as many weapons as possible in our arsenal to combat the growing global dengue threat.

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Source: www.sciencefocus.com

New Strategy Revealed by Scientists to Combat Antibiotic Resistance

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The urgent crisis of antibiotic-resistant superbugs is being solved in groundbreaking research by the University of Massachusetts Amherst and Microbiotics. Their research focuses on disrupting the pathogen’s type 3 secretion system, providing a new approach to preventing infectious diseases. This strategy, supported by innovative luciferase-based technology, could pave the way for new drugs, improve our understanding of microbial infections, and lead to major advances in public health. Credit: SciTechDaily.com

The team is developing tests to identify new drugs that neutralize pathogens and provide substantial benefits to public health.

Antibiotic-resistant “superbugs” could overwhelm efforts to eradicate “superbugs” are an imminent public health crisis, with more than 2.8 million antibiotic-resistant infections occurring each year, according to the CDC disease is occurring. Researchers around the world are struggling to address this challenge.

Recently, a collaborative team of researchers led by the University of Massachusetts Amherst and including scientists from biopharmaceutical companies microbiologypublished in a magazine ACS infection They said they have successfully learned how to interfere with a key mechanism used by pathogens to infect host cells, called the type 3 secretion system. Additionally, the researchers report that they have developed a test to identify the next generation of drugs that target this vulnerable cellular machinery and have real benefits for public health.

A typical strategy when treating microbial infections is to attack the pathogen with antibiotics, which work by entering and killing harmful cells. This is not as easy as it sounds. New antibiotics need to be water-soluble so they can easily pass through the bloodstream, and oil-based to cross the cell membranes that are the first line of defense of pathogenic cells. Of course, water and oil don’t mix. It is difficult to design a drug that has enough of both properties to be effective.

The type 3 secretion system relies on two proteins, PopB and PopD (red and blue), which form tunnels in the host cell wall.

That’s not the only problem. Antibiotics can’t cause any harm because pathogenic cells have developed something called an “efflux pump” that can recognize them and safely pump them out of the cell. If an antibiotic cannot overcome the efflux pumps and kills the cell, the pathogen will “remember” what that particular antibiotic is and create additional efflux pumps to deal with it efficiently. Develop. This means that they become resistant to that particular antibiotic.

One way forward is to find new antibiotics or combinations of them to stay one step ahead of superbugs.

“Or you could change your strategy,” says Alejandro Heuch, associate professor of biochemistry and molecular biology at the University of Massachusetts Amherst and lead author of the paper. “I am a chemist and have always been interested in understanding how chemical molecules interact with living organisms. In particular, I understand the communication between pathogens and the host cells they try to invade. We have focused our research on molecules that make this possible. If we don’t try to kill the pathogen, there’s no chance that the pathogen will develop resistance. We’re just jamming that machine. The pathogen is still alive. It’s just ineffective, and the host has no chance of developing resistance. You have time to use your natural defenses to eliminate the pathogen.”

Heuck and his colleagues are particularly interested in a communication system called the type 3 secretion system, which so far is thought to be an evolutionary adaptation unique to pathogenic microorganisms. Understanding host-pathogen interactions.

Like pathogenic cells, host cells have thick and impermeable cell walls. To overcome these, pathogens first developed syringe-like machines that secreted two proteins known as PopD and PopB. Neither PopD nor PopB can break through the cell wall on their own, but together the two proteins can create a “translocon,” the equivalent of a tunnel through the cell membrane. Once the tunnel is established, the pathogenic cell can inject other proteins that serve to infect the host. This entire process is called the type 3 secretion system, and it cannot function without both PopB and PopD. “If you don’t try to kill the pathogen, there’s no chance of it developing resistance,” Huke says. We’re just jamming that machine. The pathogen is still alive. It’s just ineffective, and the host needs time to use its natural defenses to eliminate the pathogen.

Heuck and his colleagues realized that a type of enzyme called luciferase (similar to what makes lightning bugs glow at night) could be used as a tracer. They split the enzyme into two halves. Half of it was integrated into the PopD/PopB protein and the other half was integrated into the host cell.These engineered proteins and hosts can receive a large influx of different compounds. If the host cell suddenly glows, it means that PopD/PopB has broken through the cell wall and recombined her two halves of luciferase, causing it to glow. But what if the cells remain dark? “Then we can see which molecules disrupt the translocon,” Huke says.

Huke was quick to point out that his team’s research not only has obvious applications in the pharmaceutical and public health worlds, but also advances our understanding of exactly how microbes infect healthy cells. “We wanted to study how pathogens work, and suddenly we realized that our discoveries could help solve public health problems,” he said.

Reference: “Cell-based assay to determine translocon assembly of the type 3 secretion system in Pseudomonas aeruginosa using split luciferase” by Hanling Guo, Emily J. Geddes, Timothy J. Opperman and Alejandro P. Heuck , November 18, 2023 ACS infection.DOI: 10.1021/acsinfecdis.3c00482

This research was supported by the Massachusetts Amherst Applied Life Sciences Institute, a Healey Foundation grant, and National Institutes of Health.


Source: scitechdaily.com

Scientists Develop New “Cooling Glass” to Combat Climate Change by Channeling Heat from Buildings into Space

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Innovative “cooling glass” developed by researchers at the University of Maryland provides a groundbreaking, non-electrical solution for reducing indoor heat and carbon emissions, and significantly advances sustainable building technology. It shows great progress.

Applying new coatings to exterior surfaces can reduce air conditioning usage and help fight climate change.

Researchers at the University of Maryland have developed an innovative “cooling glass” designed to reduce indoor temperatures without using electricity. This revolutionary material works by harnessing the cold air of outer space.

New technology, microporous glass coating, described in paper published in the journal sciencecan lower the temperature of the material beneath it by 3.5 degrees. Celsius According to a research team led by distinguished professor Liangbing Hu of the university’s School of Materials Science and Engineering, it has the potential to reduce the annual carbon dioxide emissions of mid-rise apartments by 10%.

Cooling mechanism with two functions

This coating works in two ways. For one, it reflects up to 99% of solar radiation, preventing buildings from absorbing heat. Even more interestingly, this universe emits heat in the form of long-wave infrared radiation into the icy universe, whose temperature is typically -270 degrees Celsius, or just a few degrees warmer. absolute temperature.

In a phenomenon known as “radiative cooling,” spaces effectively act as heat sinks for buildings. They use new cooling glass designs and so-called atmospheric transparency windows (the part of the electromagnetic spectrum that passes through the atmosphere without increasing its temperature) to dump large amounts of heat into the infinitely colder sky beyond. Masu. (Although the emissions are much stronger than those from the new glass developed at UMD, the same phenomenon causes the Earth to cool itself, especially on clear nights.)

State-of-the-art durable materials

“This is an innovative technology that simplifies the way we keep buildings cool and energy efficient,” said research assistant Xinpeng Zhao, lead author of the study. “This could help us change the way we live and take better care of our homes and the planet.”

Unlike previous attempts at cooling coatings, the new glass developed by UMD is environmentally stable, withstanding exposure to water, UV light, dirt, and even flame, and withstands temperatures up to 1,000 degrees Celsius. can withstand. Because glass can be applied to a variety of surfaces such as tile, brick, and metal, the technology is highly scalable and can be adopted for a wide range of applications.

The research team could use finely ground glass particles as a binder, bypassing polymers and increasing long-term durability outdoors, Zhao said. We then selected a particle size that maximizes the release of infrared heat while reflecting sunlight.

Climate change solutions and global impacts

The development of cooling glass is in line with global efforts to reduce energy consumption and combat climate change, Hu said, adding that this year’s Independence Day could have been the world’s hottest day in 125,000 years. He pointed out recent reports that it was a day of sex.

“This ‘cooling glass’ is not just a new material, it’s an important part of the solution to climate change,” he said. “By reducing the use of air conditioners, we have taken a big step towards reducing energy usage and reducing our carbon footprint. This is because new technology is helping us build a cooler, greener world. It shows how it can help.”

In addition to Hu and Zhao, Jelena Srebric and Zongfu Yu, professors of mechanical engineering in the University of Wisconsin-Madison’s Department of Electrical and Computer Engineering, are co-authors of the study, each contributing expertise in CO2 reduction and structural design. There is. .

The team is now focused on further testing and practical application of the cooled glass. They are optimistic about its commercialization prospects and have formed a startup company, CeraCool, to scale and commercialize it.

Reference: “Solution-processed radiatively cooled glass” Xinpeng Zhao, Tangyuan Li, Hua Xie, He Liu, Lingzhe Wang, Yurui Qu, Stephanie C. Li, Shufeng Liu, Alexandra H. Brozena, Zongfu Yu, Jelena Srebric, Liangbing Written by Hu, November 9, 2023, science.
DOI: 10.1126/science.adi2224

Source: scitechdaily.com

New molecule developed by researchers to combat antimicrobial resistance – a game-changing antibiotic breakthrough

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Researchers at Maynooth University have used supramolecular chemistry to discover new molecules to fight drug-resistant bacteria. This new discovery suggests a potential new approach to antibiotic development and has important implications for public health.Credit: Ella Mar Studio

Researchers at Maynooth University have developed a new molecule designed to fight drug-resistant bacteria.

An international team including researchers from Maynooth University has developed a new molecule that has the potential to fight drug-resistant bacteria.

Antimicrobial resistance (AMR) is a phenomenon in which bacteria, viruses, fungi, and parasites evolve over time and become immune to drugs. This resistance makes infections more difficult to cure and increases the risk of prolonged illness and death. With predictions that traditional antibiotics will largely lose their effectiveness by 2050 due to rising AMR levels, finding new ways to eradicate bacteria has become a key scientific priority.

Supramolecular chemistry: the key to fighting AMR

The research leveraged the principles of supramolecular chemistry, a niche scientific field that studies interactions between molecules, to achieve the breakthrough. Most importantly, this study discovered a molecule that is efficient at killing bacteria, yet has very low toxicity to healthy human cells.

New research published in prestigious journal chemistry, in conjunction with World AMR Awareness Week, which will be held from November 18th to 24th. This global campaign, run by the World Health Organization, aims to raise awareness and understanding of AMR in the hope of reducing the emergence and spread of drug-resistant infections.

More than 1.2 million people, and likely millions more, died as a direct result of antibiotic-resistant infections in 2019, according to the most comprehensive estimate to date of the global impact of AMR. The research could pave the way for new approaches to tackling the problem, which kills more people each year than HIV/AIDS or malaria.

Luke Brennan, lead researcher in Maynooth University’s Department of Chemistry, said: “We are discovering new molecules and investigating how they bind to anions, negatively charged chemicals that are very important in the context of the biochemistry of life.” It’s laying a fundamental foundation that could help fight a variety of diseases, from cancer to cystic fibrosis.”

A “Trojan horse” approach to resistant bacteria

The study was based on the use of synthetic ion transporters, and the researchers found that the influx of salts (sodium and chloride ions) into bacteria can trigger a series of biochemical events that lead to bacterial cell death. was demonstrated for the first time. Strains of bacteria that are resistant to currently available antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA).

Study co-author Dr Robert Hermes from the Kathleen Lonsdale Institute for Human Health at Maynooth University said: “This study shows how our approach, a kind of ‘Trojan horse’ that causes salt influx into cells, can be used to effectively kill resistant bacteria. It eliminates bacteria in a way that counters known bacterial resistance methods.”

Bacteria work hard to maintain a stable concentration of ions within their cell membranes, and when this delicate balance is disrupted, normal cell function is wreaked havoc and the cell is no longer viable.

Elms continued, “These synthetic molecules bind to chloride ions, enveloping them in a ‘blanket of fat’ and making them easily soluble in bacterial membranes, taking the ions along with them and allowing them to function normally.” Disturbs the ion balance.” This study is a great example of fundamental knowledge of chemical fundamentals that has implications for an unmet need in human health research. ”

Professor Kevin Kavanagh, microbiologist in Maynooth University’s School of Biology, commented: This research is an example of chemists and biologists working together to pioneer the development of new antimicrobial agents with great promise.”

Such results pave the way for the potential development of anion transporters as viable alternatives to currently available antibiotics, which is urgently needed as the problem of AMR continues to grow. This is what has been done.

Reference: “Strong antimicrobial effects induced by disruption of chlorine homeostasis” Luke E. Brennan, Lokesh K. Kumawat, Magdalena E. Piatek, Airlie J. Kinross, Daniel A. McNaughton, Luke Marchetti, Conor Geraghty, Conor Wynne , by Hua Tong, Oisin N. Kavanagh, Finbarr O’Sullivan, Chris S. Hawes, Philip A. Gale, Kevin Kavanagh, Robert BP Hermes, August 23, 2023. chemistry.
DOI: 10.1016/j.chempr.2023.07.014

This research was supported by Science Foundation Ireland’s Pharmaceutical Research Center (SSPC) and the Irish Research Council (IRC).

Source: scitechdaily.com