How Wild Blueberries Can Help Combat Heart Disease and Diabetes

Wild blueberry (Vaccinium angustifolium) is a perennial plant native to North America. This berry is rich in polyphenols, particularly flavonoids, which offer significant health benefits. A recent study published in Critical Reviews in Food Science and Nutrition provides a comprehensive review of the evidence and insights shared at an expert symposium regarding wild blueberries and their link to cardiometabolic health.



Vaccinium angustifolium. Image credit: Σ64 / CC BY 3.0.

Known for their high nutrient content, wild blueberries, or lowbush blueberries, are celebrated for their abundance of anthocyanins and other beneficial compounds.

These polyphenols, contributing to the berries’ vibrant blue hue, have been thoroughly researched for their powerful antioxidant properties.

“Wild blueberries have been valued for centuries,” noted University of Maine professor Dorothy Krimis Zakas, co-lead author of the recent review.

“Traditional wisdom recognizes their significance, and modern research continues to investigate how the unique constituents of wild blueberries contribute to health when part of a balanced diet.”

This review analyzed 12 human clinical trials conducted across four countries and numerous additional studies on the health effects of compounds found in wild blueberries.

The most consistent result from these studies was an improvement in vascular function, indicating better blood vessel responsiveness.

Some trials noted enhanced endothelial function just hours after consuming wild blueberries, while others observed benefits from regular intake over longer periods.

Recent studies have also highlighted the impact of wild blueberries on the gut microbiome.

Thanks to their high fiber and polyphenol content, these berries resist early digestion and are processed by gut bacteria into metabolites that enter the bloodstream.

These metabolites can constitute a significant proportion of bioactive compounds in circulation post-consumption; one study demonstrated that daily intake of freeze-dried wild blueberry powder boosted levels of beneficial bioactive compounds such as Bifidobacterium.

Emerging evidence suggests that consistent blueberry consumption may enhance cognitive abilities, especially thinking speed and memory in older adults, possibly linked to improved circulation and other systemic effects.

For adults at higher cardiometabolic risk, several studies referenced in the review identified meaningful improvements in blood pressure, glycemic control, and lipid profiles, including reductions in total cholesterol, LDL (bad) cholesterol, and triglycerides, following weeks of regular blueberry intake.

“What’s remarkable about wild blueberries is their wealth of polyphenols and nutrients. Their health benefits appear to stem from multiple mechanisms,” explained Sarah A. Johnson, Ph.D., from Florida State University, co-lead author of the review.

“Evidence indicates that these berries may influence various biological pathways related to cardiometabolic health, including vascular function and inflammation, but individual responses may vary.”

“The recent focus on the gut microbiome’s role in health benefits is intriguing and might help researchers understand how to optimize gut health for enhanced wellness.”

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Sarah A. Johnson et al. Wild blueberries and cardiometabolic health: A current review of the evidence. Critical Reviews in Food Science and Nutrition, published online January 24, 2026. doi: 10.1080/10408398.2025.2610406

Source: www.sci.news

Score Review: Can We Combat the Challenges of a Rules-Based World? Insights from a New Book

Chef skillfully slicing tomatoes from an overhead perspective

Rules-based cooking is enticing due to its capacity to yield highly reproducible outcomes.

FG Trade/Getty Images

Score
C. Thi Nguyen
Allen Lane

Last year, I penned an article for New Scientist detailing how a physicist unveiled the precise method to flawlessly cook the Italian classic, cacio e pepe. The emulsion of black pepper, pecorino cheese, and water can often turn clumpy. Ivan di Terlizzi and his team at the Max Planck Institute for the Physics of Complex Systems experimented with cacio e pepe numerous times to perfect a method that guarantees consistent results.

This topic resonated with many readers. When I recently caught up with one of the scientists involved, he suggested the draw might stem from their research’s ability to unveil order in what can otherwise appear chaotic, especially when examined through the lens of mathematics and precision.

While this perspective is captivating, it also carries risks, as C. Thi Nguyen discusses in his book, Score: How to Stop Playing Someone Else’s Game. Formerly a food critic, Nguyen is now a philosophy professor at the University of Utah in Salt Lake City. He cautions that recipes promising flawless results can obscure the essential values of food as “an exercise of taste and preference.”

By employing scientific rigor—exact measurements and meticulous procedures—the outcomes might be repeatable, but this approach diminishes the diversity of culinary experiences and the delightful chaos that food can represent.

Cooking serves as merely one instance illustrating how modern tendencies to systematize and impose order on chaotic realities—often driven by state bureaucracies—can result in less-than-ideal outcomes. Nguyen constructs a vivid image of a world rife with such consequences.

Using his own academic journey as a reference, Nguyen contends with the rankings that universities and magazines impose. In philosophy, these ratings often derive from websites evaluating departments based on criteria like publishing prestige or scholars’ ability to address specialized queries, contrasting sharply with the “wild, unruly questions” that initially piqued his interest in philosophy. He began to sense a phenomenon he labeled “value capture,” where metrics intended to guide us begin to dictate our actions.

Nguyen argues for embracing these intricate rule-based systems by engaging in games as a means to explore and remain open to life’s experiences. This book encompasses a diverse array of his recreational pursuits, from Dungeons & Dragons to rock climbing, yoga, and yo-yo.

He effectively illustrates why choosing to abide by the rules within a game serves as a “spiritual vaccine” against societal pressures to conform to institutional scoring systems, like those found in educational assessments. While the notion that games can save us may seem optimistic, Nguyen compellingly presents it as a refreshing perspective.

Many of Nguyen’s concepts aren’t groundbreaking, drawing from numerous influential philosophers and scholars shaping his thought process—including Tim Marshall’s Prisoners of Geography, which explains the influence of geography on geopolitics, and James C. Scott’s Seeing Like a State, which scrutinizes the shortcomings of scientifically planned societies.

However, Nguyen’s imaginative approach to discussing the core themes of his book ensures the conversation remains engaging and thought-provoking. This work provides a compelling starting point for further exploration.

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Source: www.newscientist.com

How Bacteria and Viruses Collaborate to Combat Cancer: Insights from Sciworthy

The history of cancer can be traced back to ancient Egyptian civilizations, where it was thought to be a divine affliction. Over the years, great strides have been made in understanding cancer’s causes and exploring diverse treatment options, although none have proven to be foolproof. Recently, a research team at Columbia University has pioneered a novel method for combating cancerous tumors by utilizing a combination of bacteria and viruses.

The researchers engineered this innovative strategy by infecting bacterial cells with Typhimurium that were modified to carry the Seneca virus A. The theory posited that when tumor cells engulf these bacteria, they would also take in the virus, which would then replicate within the cells, leading to their death and the subsequent distribution of the virus to surrounding cells. This technique has been termed Coordinated Activities of Prokaryotes and Picornaviruses for Safe Intracellular Delivery (CAPPSID).

Initially, the research team verified that Typhimurium was a suitable host for Seneca virus A. They infected a limited number of these bacteria with a modified variant of the virus that emitted fluorescent RNA. Subsequently, they applied a solution that facilitated viral entry into the bacteria. Using fluorescence microscopy, they confirmed the presence of viral RNA inside the bacterial cells, validating the infection. To further assist the viral RNA in escaping the bacteria and reaching cancer cells, the researchers added two proteins, ensuring that viral spread was contained to prevent infection of healthy cells.

After optimizing the bacteria and virus, the team tested the viral delivery system on cervical cancer samples. They found that viral RNA could replicate both outside of bacterial cells and inside cancer cells. Notably, newly synthesized RNA strands were identified within tumor cells, confirming the successful delivery and replication of the virus through the CAPPSID method.

Next, the researchers examined CAPPSID’s impact on a type of lung cancer known as small cell lung cancer (SCLC). By tracking fluorescent viral RNA within SCLC cells, they assessed the rate of viral dissemination post-infection. Remarkably, the virus continued to propagate at a consistent rate for up to 24 hours following the initial infection, demonstrating effective spread through cancerous tissue without losing vigor.

In a follow-up experiment, the researchers evaluated the CAPPSID method on two groups of five mice, implanting SCLC tumors on both sides of their backs. They engineered the Seneca virus A to generate a bioluminescent enzyme for tracking purposes and injected the CAPPSID bacteria into the tumors on the right side. Two days post-injection, the right-side tumor glowed, indicating active viral presence. After four days, the left-side tumor also illuminated, suggesting that the virus had successfully navigated throughout the mice’s bodies while sparing healthy tissues.

The treatment continued for 40 days, leading to complete tumor regression within just two weeks. Remarkably, upon observation over a subsequent 40-day period, the mice demonstrated a 100% survival rate, with no recurrence of cancer or significant side effects. The research team observed that the CAPPSID virus, being encapsulated by bacteria, could circumvent the immune response, thus preventing cancer cells from building immunity against it.

Finally, to prevent uncontrolled replication of Seneca virus A, the researchers isolated a gene from a tobacco virus responsible for producing an enzyme that activates a crucial protein in Seneca virus A. By incorporating this gene into the Typhimurium bacteria, they were able to independently produce this enzyme, ensuring the virus could not replicate or spread without the bacteria’s presence. Follow-up tests confirmed that this modified CAPPSID method improved viral spread while maintaining confinement within cancer-affected areas.

The research findings hold promising potential for the development of advanced cancer therapies. The remarkable regression of tumors in mice and the targeted delivery system of CAPPSID—without adverse effects—could lead to safer cancer treatments for human patients, eliminating the need for radiation or harmful chemicals. However, the researchers also cautioned about the risk of viral and bacterial mutations that may limit the effectiveness of CAPPSID and cause unforeseen side effects. They suggested that enhancing the system with additional tobacco virus-derived enzymes could help mitigate these challenges, paving the way for future research into innovative cancer therapies.

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Source: sciworthy.com

Breakthrough Antibiotic May Combat Drug-Resistant Gonorrhea

gonorrhea

J. Marshall/Tribaleye Image/Alamy

Worldwide, drug-resistant gonorrhea is increasing, yet new antibiotics may provide a temporary solution until we face bacterial strains that cannot be treated at all, which heightens the risk of infertility.

Every year, it is estimated that sexually transmitted infections affect over 80 million individuals globally. Gonorrhea infections can spread to various body parts, including the anus, urethra, and genitals. Symptoms often include a burning sensation during urination and unusual discharge from genital areas. Untreated infections can lead to complications such as infertility and miscarriage.

Typically, the treatment for gonorrhea involves ceftriaxone injections, which remain effective against most strains. However, resistance is developing, and the World Health Organization reported that in 2024, about 5 percent of cases in 12 countries, including Thailand, South Africa, and Brazil, showed resistance to ceftriaxone—a sixfold increase since 2022.

When ceftriaxone fails, doctors typically resort to alternative antibiotics. However, it’s only a matter of time before completely untreatable strains appear. “We’re running out of options,” states Alison Luckey from the Global Antibiotic Research and Development Partnership. “It’s been decades since a new treatment for gonorrhea has been approved.”

To combat this escalating issue, researchers found that gepotidacin, an antibiotic pill used for urinary tract infections, can effectively treat gonorrhea, and the U.S. Food and Drug Administration (FDA) is now reviewing the drug for U.S. approval. However, as bacteria evolve resistance to new medications, expanding treatment options is crucial, according to Lackey.

She and her team are currently studying another medication, zoliflodacin, specifically created to combat drug-resistant gonorrhea. In a study, 744 gonorrhea patients from the U.S., South Africa, Thailand, Belgium, and the Netherlands were randomly assigned to receive either zoliflodacin or a combination treatment that includes ceftriaxone and a second antibiotic, azithromycin.

After six days of testing through swabs of participants’ cervixes or urethras, results showed that zoliflodacin effectively cleared roughly 91 percent of infections, while standard treatment had a similar success rate of around 96 percent. Hence, no significant differences were observed between the two treatments, with side effects like headache and nausea being similar and short-lived in both groups.

Most of the 744 tested cases involved strains that were not resistant to ceftriaxone or azithromycin, but prior research indicated that zoliflodacin can effectively target N. gonorrhoeae strains resistant to all standard antibiotics. These findings suggest that zoliflodacin may represent a promising new strategy for treating gonorrhea, both as a first-choice treatment and when traditional options fail, as Lackey observes. “In areas with frequent resistance, early implementation as a primary treatment option could be beneficial,” she adds. Furthermore, since zoliflodacin is administered orally, it may provide a more convenient alternative than ceftriaxone, which some patients avoid due to needle aversion.

Researchers have already submitted findings to the FDA, with a ruling anticipated by December 15, according to Lackey.

If the FDA grants approval, other regions, including the UK, Europe, and Asia, could follow suit shortly, as noted by Charlotte Eve Short from Imperial College London, who was not part of the research.

Alongside ongoing vaccination efforts against gonorrhea, including the recent rollout of the Meningitis Group B vaccine in the UK, the introduction of these two new drugs could signify a pivotal moment in the battle against drug-resistant gonorrhea, according to Short. “This is excellent news,” she states. “While the population-level implications remain uncertain, our dual focus on prevention and treatment should help us significantly reduce resistance rates.”

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  • antibiotics/
  • sexually transmitted diseases

Source: www.newscientist.com

Experts Urge Immediate Action to Combat Climate Change

Wildfires in California this January exacerbated by climate change

Josh Edelson/AFP via Getty Images

Famine, economic downfall, civil unrest, and conflict are serious threats we encounter unless we take urgent steps to curb further global warming and safeguard nature, leading climate, food, health, and security specialists cautioned in London today.

A national emergency briefing organized by climate activists and researchers aims to persuade politicians of the necessity for immediate and significant action regarding the intertwined crises of climate and biodiversity.

“I’m fearful for my life and future, and even more for my son’s,” stated Hugh Montgomery, a doctor at University College London focused on climate change’s impact on health.

“We require leadership on par with that of World War II, as if the survival of society depended on it—because it truly does,” remarked Mike Berners-Lee, who led the event at Lancaster University in the UK.

He indicated new evidence suggests the planet is heating up more rapidly than before, as noted by Kevin Anderson from the University of Manchester. “There exists a small but very real possibility that temperatures could reach 4°C by the end of this century.”

“The potential for 3°C or 4°C of warming is incredibly severe. We simply cannot afford to take that risk. It presents an extreme and unstable climate far beyond the conditions that have supported our civilization,” Anderson warned. “We will witness an unparalleled social and ecological breakdown at such levels. Geopolitical tensions will heighten, and there will likely be no viable economy left. A systemic collapse awaits us.”

Anderson cautioned against what he termed “delay technologies,” which aim to maintain the prosperity of the oil and gas sector. These encompass hydrogen and bioenergy with carbon capture and storage, according to him.

Hayley Fowler, a researcher at the University of Newcastle in the UK, stated that the impacts of warming are exceeding expectations. “Heat waves in Europe are escalating quicker than anywhere else globally and significantly faster than climate models predict,” she remarked.

The UK could face storms capable of releasing up to 35 centimeters of rain, leading to severe flooding as experienced in Germany in 2021. “However, like the people of Germany, we often fail to comprehend this until it occurs,” Fowler noted.

She emphasized that nations are unprepared for such extreme weather conditions. “We continue to construct infrastructure that cannot endure today’s climate, let alone what lies ahead.”

Tim Renton, a researcher from the University of Exeter in the UK, alerted about the danger of triggering critical tipping points, such as the potential collapse of the Atlantic Meridional Overturning Circulation (AMOC).

If the AMOC collapses, Arctic sea ice may extend southward as far as the North Sea during winter, Renton explained. London, for three months each year, could see temperatures plunge below freezing, with lows reaching -20°C (-4°F), but summers could be hotter than currently experienced.

Renton warned that Britain could face water shortages and an inability to produce food. “Globally, more than half of the area will become incapable of cultivating wheat and corn, leading to a major food security crisis,” he said.

He cited that food production has already been adversely impacted, as noted by Paul Behrens from Oxford University. “In the past decade, the UK has recorded three of its five worst grain harvests,” he pointed out.

Behrens cautioned that the situation is poised to worsen, leading to civil unrest. “We are at a crossroads: we can either allow our food system to collapse and continue our current trajectory, preparing for political and social turmoil, or we can take action now.”

Richard Nagy, a former British Army lieutenant general and national climate and security adviser, expressed concern over national security risks. “What troubles me most is not one crisis but a series of crises. Multiple crises converging—food, health, infrastructure, immigration, energy, extreme weather—where slow or ineffective responses erode public trust in government, resulting in a reactionary political climate that promises to tackle all these crises simultaneously.”

“We must realistically anticipate a future that others may fail to envision or wish to ignore, a future with monumental consequences if realized. Just because we may not like risk doesn’t mean it will disappear or that we can turn a blind eye to it,” Nuzi commented.

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Source: www.newscientist.com

Ofcom Calls on Social Media Platforms to Combat Fraud and Curb Online ‘Pile-Ons’

New guidelines have urged social media platforms to curtail internet “pile-ons” to better safeguard women and girls online.

Ofcom, Britain’s communications regulator, implemented guidance on Tuesday aimed at tackling misogynistic abuse, coercive control, and the non-consensual sharing of intimate images, with a focus on minimizing online harassment of women.

The measures imply that tech companies will limit the number of responses to posts on platforms like X, a strategy Ofcom believes will lessen incidents where individual users are inundated with abusive responses.


Additional measures proposed by Ofcom include utilizing databases of images to prevent the non-consensual sharing of intimate photos—often referred to as ‘revenge porn’.

The regulator advocates for “hash matching” technology that helps platforms remove disputed images. This system cross-references user-reported images or videos with a database of illegal content, transforming them into “hashes” or digital identifiers, enabling the identification and removal of harmful images.

These recommendations were put forth under the Online Safety Act (OSA), a significant law designed to shield children and adults from harmful online content.

While the advice is not obligatory, Ofcom is urging social media companies to follow it, announcing plans to release a report in 2027 assessing individual platforms’ responses to the guidelines.

The regulator indicated that the OSA could be reinforced if the recommendations are not acted upon or prove ineffective.

“If their actions fall short, we will consider formally advising the government on necessary enhancements to online safety laws,” Ofcom stated.

Dame Melanie Dawes, Ofcom’s chief executive, has encountered “shocking” reports of online abuse directed at women and girls.


Melanie Dawes, Ofcom’s chief executive. Photo: Zuma Press Inc/Alamy

“We are sending a definitive message to tech companies to adhere to practical industry guidance that aims to protect women from the genuine online threats they face today,” Dawes stated. “With ongoing support from our campaigners, advocacy groups, and expert partners, we will hold companies accountable and establish new benchmarks for online safety for women and girls in the UK.”

Ofcom’s other recommendations suggest implementing prompts to reconsider posting abusive content, instituting “time-outs” for frequent offenders, and preventing misogynistic users from generating ad revenue related to their posts. It will also allow users to swiftly block or mute several accounts at once.

These recommendations conclude a process that started in February, when Ofcom conducted a consultation that included suggestions for hash matching. However, more than a dozen guidelines, like establishing “rate limits” on posts, are brand new.

Internet Matters, a nonprofit organization dedicated to children’s online safety, argued that governments should make the guidance mandatory, cautioning that many tech companies might overlook it. Ofcom is considering whether to enforce hash matching recommendations.

Rachel Huggins, co-chief executive of Internet Matters, remarked: “We know many companies will disregard this guidance simply because it is not legally binding, leading to continued unacceptable levels of online harm faced by women and girls today.”

Source: www.theguardian.com

Empowering Young Gamers: Harnessing Online Skills to Combat Cybercrime and How Parents Can Support Them

The rapid technological advancements can widen the gap between parents and teens. Gen

Moreover, a rise in cyberattacks affecting major companies has been frequently reported. Interestingly, many of those who face these hacks are young individuals equipped with advanced digital skills. In fact, the National Crime Agency reports that one in five children engages in unlawful activities under the Computer Fraud Act, which penalizes unauthorized access to computer systems or data. This statistic rises to 25% among gamers.

To combat this, co-ops adopt a unique preventive strategy. As part of our long-term mission to empower young people to harness their technology skills, Co-op has teamed up with a hacking game aimed at helping talented gamers secure positions in the cybersecurity sector.

This collaborative model is crucial because, as Greg Francis, former senior officer at the National Crime Agency and director of 4D Cyber Security, puts it, “A digital village is necessary to nurture digital natives.” Early intervention is essential, and parents play a pivotal role. “Parents are vital as they wield significant influence, but they shouldn’t remain passive. They should grasp the fundamentals of the hacker universe,” notes Francis, who also serves as Hacking Game’s Cyber Ambassador. So, where to begin?

Show Interest Without Judgment

First and foremost, having an interest in hacking isn’t inherently negative.

“Ethical hacking is an exhilarating and rapidly evolving domain, making it completely understandable for children to find it intriguing,” says Lynne Perry, CEO of children’s charity Barnardo’s. The organization collaborates with co-ops to generate funds to support young individuals in forging positive futures.

Maintaining an open dialogue is just as critical as beginning discussions early. “The ideal moment to start is now,” states Perry. “Once your child shows an interest in online technology, it’s time. Frequent, age-appropriate discussions are essential to keep the lines of communication open.”

Activities that seem innocuous can lead to a path towards cybercrime. Composite: Stocksy/Guardian Design

Perry advises involving children in online activities from a young age. “Explore technology together and discuss what to do if something unusual or concerning occurs. As kids mature, they may seek more independence, but regular interaction allows them to steer conversations, ask questions, and express concerns.”

For parents who grew up in a simpler digital age, grasping the complexities of today’s online gaming, dominated by franchises like Roblox, Minecraft, and Call of Duty, might seem daunting. However, both Francis and Perry emphasize that you don’t need to have all the answers to provide support.

Parents should check game age ratings and utilize parental controls, such as friend-only features, to enhance the security of in-game chats. For online resources, check Ask About Games for detailed information on popular games and guides to setting up safety measures.

It’s also beneficial to inquire if your young gamer has ever experienced being “booted” offline. Booting refers to a DDoS (Distributed Denial of Service) attack, where someone hacks another gamer’s IP address and floods it with data, causing an Internet outage. While booting may seem innocuous among gamers, it is a serious issue. Francis clarifies: “They may not realize this infringes on the Computer Misuse Act.” In fact, booting is identified as one of the initial steps towards cybercrime, as noted during Francis’s work with various prevention programs.

Asking questions aligns with observing potential warning signs like excessive gaming, social withdrawal, unexplained tiredness, unusual purchases of equipment or technology (especially if you’re unaware of how it was paid for), and multiple email addresses. While one sign alone might not be serious, a combination of them can be concerning.

Mary* faced these warning signs firsthand. “I had a son engaged in hacking on the darknet. He isolated himself and avoided sleep. I truly had no clue about his activities,” she shares. “After consulting a cybersecurity expert and discussing my challenges, I discovered he was attempting to delve into the cryptocurrency world on the darknet at just 13 years old.”

Guidance from trusted sources inspires talented young individuals to utilize their skills positively. Composite: Getty Images/Guardian Design

A Transformative Path for Neurodivergent Youth

Particularly for neurodivergent youth, engaging with games and spending time online can yield significant advantages in terms of socialization and emotion regulation. Yet, it’s crucial to recognize that with these benefits come potential drawbacks, including the considerable risks of internet or gaming addiction and the associated allure of cybercrime.

However, over 50% of technology professionals identify as neurodivergent, according to the Tech Talent Charter, indicating vast opportunities for neurodivergent young individuals in this sector. This is why The Hacking Games directly targets “digital rebels” showcasing “raw talent” and “unconventional thinking,” matching them with cybersecurity job opportunities, mentors, and fostering community through Discord group chats.

As Mary can confirm, mentorship and career awareness can be life-changing. “Cyber experts supported my son as a credible source of information and ultimately coached him on my behalf,” she states. “They helped him realize that he could channel his skills for impactful purposes. Consequently, he began assisting others.”

While this situation may seem alarming, there are numerous ways for parents to intervene positively. Approaching the subject with curiosity and care, rather than judgment, is paramount for guiding your child in the right direction. Here are some suggestions for parents who are concerned about their kids.

1 Begin conversations regarding online gaming safety early, approaching the topic with sensitivity rather than judgment. Remaining calm fosters open communication.

2 You don’t need to be fully informed, but a genuine interest can lead to insightful discussions. Ask your child about their games and online activities. Just as you would inquire about who they play with at a park, ask the same about their online friends. Be vigilant for warning signs like strangers trying to befriend them, offering freebies, or inviting them to unfamiliar worlds or games, as these could indicate grooming.

3 Take proactive measures. Pay attention to age ratings for games, which are significant. The best way to ascertain what is suitable for your child is to play the game together or at least observe them while they play. Remember, just like in Call of Duty, children can also be recruited in games like Minecraft. Games with community or “freemium” options can entice young players seeking extra income through in-game purchases or upgrades.

4 Monitor for warning signs such as social withdrawal, excessive gaming, lack of sleep, unusual tech purchases, and multiple email accounts.

5 Engage with your child’s school. Consult their computer science teacher to learn how they promote digital responsibility. Teachers often have insight into which students may require specific support to enhance their skills. This could serve as an early opportunity to channel their talents positively through initiatives like Cyber First and Cyber Choices or coding communities such as Girls Who Code.

*Mary’s name has been changed to protect her family’s anonymity.

Discover more

Ensure online safety for children and young individuals with Barnardo’s online safety guidance

Source: www.theguardian.com

Bryan Cranston Appreciates OpenAI’s Efforts to Combat Sora 2 Deepfakes

Bryan Cranston expressed his “gratitude” to OpenAI for addressing deepfakes of him on its generative AI video platform Sora 2. This action follows instances where users managed to create his voice and likeness without his permission.

The Breaking Bad actor has voiced concerns to actors’ union Sag Aftra after Sora 2 users generated his likeness during the platform’s recent launch. On October 11th, the LA Times reported that in one instance, “a synthetic Michael Jackson takes a selfie video using an image of Breaking Bad star Bryan Cranston.”


To appear in Sora 2, living individuals must provide explicit consent or opt-in. Statements following the release from OpenAI confirmed it has implemented “measures to block depictions of public figures” and established “guardrails to ensure audio and visual likenesses are used with consent.”

However, upon Sora 2’s launch, several articles emerged, including those from the Wall Street Journal, Hollywood Reporter, and LA Times, which reported that OpenAI instructed several talent agencies that if they didn’t want their clients’ or copyrighted material to be featured in Sora 2, they needed to opt-out instead of opt-in, causing an uproar in Hollywood.

OpenAI contests these claims and told the LA Times its goal has always been to allow public figures to control how their likenesses are utilized.

On Monday, Cranston released a statement via Sag Aftra thanking OpenAI for “enhancing guardrails” to prevent users from generating unauthorized portraits of himself.

“I was very concerned, not only for myself but for all performers whose work and identities could be misappropriated,” Cranston commented. “We are grateful for OpenAI’s enhanced policies and guardrails and hope that OpenAI and all companies involved in this endeavor will respect our personal and professional rights to control the reproduction of our voices and likenesses.”

Hollywood’s top two agencies, Creative Artists Agency (CAA) and United Talent Agency (UTA), which represents Cranston, have repeatedly highlighted the potential dangers Sora 2 and similar generative AI platforms pose to clients and their careers.

Nevertheless, on Monday, UTA and CAA released a joint statement alongside OpenAI, Sag Aftra, and the Talent Agents Association, declaring that what transpired with Cranston was inappropriate and that they would collaborate to ensure the actor’s “right to determine how and whether he can be simulated.”


“While OpenAI has maintained from the start that consent is required for the use of voice and likeness, the company has expressed regret over these unintended generations. OpenAI has reinforced its guardrails concerning the replication of voice and likeness without opt-in,” according to the statement.

Actor Sean Astin, the new chair of SAG Aftra, cautioned that Cranston is “one of many performers whose voices and likenesses are at risk of mass appropriation through reproduction technology.”

“Bryan did the right thing by contacting his union and professional representatives to address this issue. We now have a favorable outcome in this case. We are pleased that OpenAI is committed to implementing an opt-in protocol, which enables all artists to decide whether they wish to participate in the exploitation of their voice and likeness using AI,” Astin remarked.

“To put it simply, opt-in protocols are the only ethical approach, and the NO FAKES law enhances our safety,” he continued. The Anti-Counterfeiting Act is under consideration in Congress and aims to prohibit the production and distribution of AI-generated replicas of any individual without their consent.

OpenAI has openly supported the No FAKES law, with CEO Sam Altman stating the company is “firmly dedicated to shielding performers from the misuse of their voices and likenesses.”

Sora 2 permits users to generate “historical figures,” which can be broadly defined as both well-known and deceased individuals. However, OpenAI has recently acknowledged that representatives of “recently deceased” celebrities can request for their likeness to be blocked from Sora 2.

Earlier in the month, OpenAI announced its partnership with the Martin Luther King Jr. Foundation to halt the capability of depicting King in Sora 2 at their request as they “strengthened guardrails around historical figures.”

Recently, Zelda Williams, the daughter of the late actor Robin Williams, pleaded with people to “stop” sending her AI videos of her father, while Kelly Carlin, the daughter of the late comedian George Carlin, characterized her father’s AI videos as “overwhelming and depressing.”

Legal experts speculate that generative AI platforms could enable the use of deceased historical figures to ascertain what is legally permissible.

Source: www.theguardian.com

Living at High Altitudes Could Help Combat Obesity

Research reveals obesity rates among children in Colombia’s hilly capital, Bogotá

Guillermo Legaria/Getty Images

A study involving over 4 million children in Colombia suggests that living at high altitudes may help in preventing obesity.

This outcome is consistent with existing research. Higher altitudes are thought to reduce obesity, potentially due to increased energy expenditure at lower oxygen levels. Most studies, however, have focused primarily on adults.

To explore the effect on children, Fernando Lizcano Rosada from Lhasavanna University in Chia, Colombia, along with his team analyzed data concerning 4.16 million children from municipalities up to age 5, sourced from the Colombian Institute of Family Welfare.

The participants were categorized into four groups based on the altitudes where they resided.

In two low-altitude areas, about 80 out of every 10,000 children were classified as obese. In contrast, at altitudes of 3,000 meters or higher since 2001, this rate dropped to 40 per 10,000.

However, at elevations above 3,000 meters, the prevalence rose again, reaching 86 out of 10,000. The researchers caution that this might be a statistical anomaly since it is based on data from only seven municipalities and 11,498 individuals, substantially fewer than the data for the other altitude groups.

“That’s a valid observation,” states David Stencel from Loughborough University, UK. He notes that a dose-response relationship would have strengthened the findings.

Stencel also underscores that the study is observational, meaning it does not definitively prove that high altitudes reduce obesity risk. “The research takes into account various confounding factors,” he explains, including measures of poverty. Yet, he adds, “we cannot account for everything.”

Nevertheless, he sees this research as a promising commencement. “It establishes a relationship that calls for more tailored studies to verify the hypothesis independently.”

Lizcano Rosada posits that metabolism may be heightened at higher altitudes, leading to increased energy expenditure.

This claim is plausible, Stencel agrees. “Some studies indicate that resting metabolic rates may be elevated at high altitudes,” he notes. For instance, a 1984 study found that climbers tended to lose more weight at high altitudes partly because fat from food was burned or expelled before being stored as tissue.

More recent studies suggest that lower oxygen levels may lead to accelerated metabolism and increased levels of leptin, the hormone related to satiety, while levels of ghrelin, often associated with hunger, are reduced.

If it is indeed true that high altitude diminishes obesity risk, Stencel notes that the practical application of this knowledge in combating obesity remains ambiguous. Nonetheless, Lizcano Rosada asserts that personalized advice could be beneficial, acknowledging that diverse environmental factors contribute to obesity across various locales.

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Source: www.newscientist.com

Arts and Media Groups Call for AI Training to Combat “Ramp Theft” of Australian Content

Arts, creative, and media organizations are urging the government to prohibit large tech companies from using Australian content and developing artificial intelligence models. There is growing concern that such a decision may “betray” Australian workers and facilitate the “widespread theft” of intellectual property.

The Albanese government has stated that it has no intention of altering copyright laws, but emphasizes that any changes must consider their effects on artists and news media. Opposition leader Sassan Ray has called for compensation for any use of copyrighted material.

“It is unacceptable for Big Tech to exploit the work of Australian artists, musicians, creators, and journalists without just compensation,” Ray asserted on Wednesday.


The Productivity Committee’s interim report titled “Utilizing Data and Digital Technology” proposes regulations for technologies, including AI in Australia, projecting a productivity increase of 0.5% to 13% over the next decade, thereby potentially adding $116 billion to the nation’s GDP.

The report highlighted that building AI models demands a substantial amount of data, prompting concerns from many players, including Creative Australia and copyright agencies, about the misuse of copyrighted content for AI training.

The committee outlined potential solutions, advocating for an expansion of licensing agreements, exemptions for “text and data mining,” and enhancements to existing fair trading regulations that are already in place in other countries.

This latter suggestion faced significant opposition from arts, creative, and media organizations. They expressed discontent at the idea of allowing wealthy tech companies to utilize their work for AI training without appropriate compensation.

Such a shift could jeopardize existing licensing agreements formed between publishers and creators with major tech firms and complicate negotiations for news media seeking fair compensation from social media platforms for journalism online.

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The Australian Labour Union Council (ACTU) criticized the Productivity Committee’s proposal, claiming it exploits the interests of large multimillion-dollar corporations, warning that it may mislead efforts to assist Australian workers.

“The extensive discussion surrounding text and data mining exemptions risks normalizing the theft of creative works from Australian artists and Indigenous communities,” said ACTU.

Joseph Mitchell, ACTU Secretary, indicated that such exemptions would allow “high-tech corporations to reap the full benefits of advanced technology without giving back to the creators.”

APRA Chair Jenny Morris is among those who have voiced concerns over potential exemptions for “text and data mining” used in AI training. Photo: AAP

Australia’s music rights organizations, Apra Amcos and the National Aboriginal and Torres Strait Islander Music Bureau, expressed disappointment regarding the committee’s recommendations, raising alarms about the implications for Australia’s $9 billion music sector.

APRA Chair Jenny Morris stressed that this recommendation highlights a recognition that these practices are already widespread.

Attorney General Michelle Roland, responsible for copyright legislation, stated that any advancements in AI must prioritize building trust and confidence.

“Any reforms to Australia’s copyright law must reflect the effects on the nation’s creative and news sectors. We remain dedicated to participating in dialogues around these issues, particularly with the copyright and AI reference groups initiated by the government last year,” she mentioned.

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When asked about the committee’s findings, Ray expressed concern regarding the absence of sufficient “guardrails” from the government to tackle AI-related issues.

“We need to safeguard content creators… their work rightfully belongs to them, and we must not take it without compensating them,” she added.

Ed Fushik, former Minister for Industry and Technology for Workers, defended the overall outlook for the economy on Wednesday. Treasurer Jim Chalmers later commented on ABC’s 7.30, saying, “The mechanism you deploy, whether one act or multiple existing acts… is not the crux of the issue.”

“I believe we can strike a balance between concerns that AI is harmful and those who pretend we can return to a previous state,” he indicated.

“There are no current plans to undermine or alter Australia’s copyright arrangements.”

Arts Minister Tony Burke highlighted a submission from Creative Australia regarding the review. He stated that, “It emphasizes the necessity for consent, transparency, and fair compensation concerning copyright and labeling.”

In a statement, Creative Australia asserted that the nation has the potential to lead globally in establishing “fair standards” for AI application.

“Artists and creatives whose work is utilized in training AI are entitled to proper compensation,” a spokesperson remarked.

“Innovation should not come at the cost of ethical business practices.”

The Australian Publishers Association (APA) has expressed worries about the possibility of works being utilized without authorization or compensation.

“While we support responsible innovation, this draft proposal favors infringers over investors,” stated Patrizia Di Biase-Dyson, CEO of APA.

“We oppose the idea that Australian narratives and educational materials integral to our culture and democracy should be treated as free resources for corporate AI systems.”

The copyright agency likewise spoke against the text and data mining exemption, emphasizing that it would adversely affect creators’ revenue.

“The movement towards revision of the Australian copyright system stems from large multinational corporations, and it does not serve the national interest,” remarked CEO Josephine Johnston. “To empower Australia’s high-quality content in the new AI era, it’s critical that creators receive fair compensation.”

Source: www.theguardian.com

Immobilized Lifestyle Changes Are the Most Common Approach to Combat Cognitive Decline

Regular exercise aids in maintaining cognitive sharpness

Yoshikazu Tsuno/AFP via Getty Images

Engaging in structured exercise programs, dietary changes, cognitive activities, and social interactions has proven more efficient in combating cognitive decline than casual, self-initiated efforts.

The brain’s capabilities for memory, language use, and problem-solving typically diminish with age, often resulting in dementia. Nevertheless, studies indicate that up to 45% of global dementia cases are preventable by addressing 14 risk factors, which include inadequate education, social isolation, and brain injuries.

To explore strategies for preventing cognitive decline, Laura Baker from Wake Forest University School of Medicine in North Carolina and her team studied the American Pointer Study.

They involved over 2,100 individuals deemed at high risk for cognitive decline aged between 60 and 79, who led sedentary lifestyles, had suboptimal diets, and met at least two criteria related to dementia, such as a family history of memory issues.

Participants were randomly placed into one of two groups. Both were designed to promote physical and cognitive activity, healthy eating habits, and social interaction, although their methods varied.

One group followed a highly structured format, with 38 small group sessions across two years, led by trained facilitators who devised plans. This regimen also incorporated regular exercise at a community center along with weekly online brain training exercises.

The other group was less structured, participating in only six group meetings over the same two-year period. They were provided with public education materials and $75 gift cards aimed at encouraging behavioral changes, like attending gym classes.

After two years, both groups demonstrated enhancements in cognitive assessments measuring memory, executive function, and processing speed. The structured group saw an improvement of 0.24 standard deviations per year compared to their initial scores, while the self-guided group improved by 0.21 standard deviations per year.

“It’s remarkable that the structured care group has shown improvement,” remarks Gil Livingston from University College London. However, she points out the absence of a control group that received no intervention, making comparisons challenging between structured and self-directed participants.

Baker estimates significant declines in cognitive scores would have occurred without either regimen, claiming the benefits are significant. “A two-year structured intervention can effectively delay cognitive aging by nearly one to two years,” she states.

Baker mentions that improvement in both groups aligns with a placebo effect, suggesting that participants might have expected positive outcomes regardless of their group assignments.

Claudia Sumoto from the University of São Paulo in Brazil suggests the minor differences in cognitive scores between groups are likely imperceptible to participants and their families, given that dementia progresses gradually; clear effects may take more than two years to manifest.

Baker notes the team will continue monitoring participants for a total of six years, as the US Pointer Study has a four-year extension. “We’re observing subtle changes because they are cognitively normal individuals, and we are effectively slowing the rate of decline over time. We’re genuinely excited about empowering individuals at risk of dementia to take control of their health,” she remarks.

She believes that a structured approach is practical beyond the study context, emphasizing the need for caregivers and health professionals to motivate individuals rather than assuming high public expenditure is necessary to instill healthy habits.

“Overall, dementia care can be highly costly, and mitigating the burden can save expenses,” Livingston adds. “This study is crucial because lifestyle enhancements have shown benefits, and while guided support aids improvement, it’s not the only approach.”

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Source: www.newscientist.com

A Healthy Baby Conceived with Three DNA Sources to Combat Hereditary Diseases

LONDON – Eight healthy babies have been born in the UK, aided by experimental techniques designed to prevent mothers from transmitting severe rare diseases to their offspring through DNA, researchers have announced.

The majority of DNA resides within the nuclei of our cells and is inherited from both our mothers and fathers—essentially, it shapes who we are. However, mitochondria, the cell’s energy-producing structures, also contain DNA outside the nucleus. Mutations in this mitochondrial DNA can lead to various illnesses in children, resulting in symptoms like muscle weakness, seizures, developmental delays, major organ failure, and even death.

In vitro fertilization (IVF) testing typically helps identify these mutations, although there are instances where this is not evident.

Researchers have pioneered methods to circumvent these issues by employing healthy mitochondria from donor eggs. They reported their findings in 2023 in an article detailing the birth of the first babies born using this technique, which involves extracting genetic material from the mother’s eggs or embryos and transferring it to a donor egg or embryo possessing healthy mitochondria, while discarding the bulk of its original DNA.

Dr. Zev Williams, head of the Fertility Center at Columbia University and not involved in this study, stated that this research “marks a significant milestone.” He believes that broadening reproductive choices will allow more couples to achieve a safe and healthy pregnancy.

This method results in an embryo containing DNA from the mother, the father, and the donor’s mitochondria—an approach that became legally viable in the UK after law changes in 2016. Similar procedures are also permitted in Australia, though they remain banned in many countries, including the US.

Experts from Newcastle University in the UK and Monash University in Australia reported in the New England Journal of Medicine that they successfully implemented these new methods for fertilizing embryos from 22 patients, with one woman still pregnant.

Footage released by the Newcastle Fertility Center shows delicate IVF procedures.
Fertility Centre in Newcastle

One of the eight babies born exhibited unexpectedly high levels of abnormal mitochondria, according to Robin Lovell-Badge, a stem cell and developmental genetics scientist at the Francis Crick Institute, who was not involved in the research. While these levels are not currently deemed harmful, monitoring is required as the baby grows.

Andy Greenfield, a reproductive medicine expert at Oxford University not associated with the research, emphasized its significance, noting that mitochondrial replacement techniques are primarily used in other settings aimed at avoiding genetic illnesses, like early-stage embryo testing.

“This technique was certified a decade ago, so we have all been anticipating this report,” he shared with NBC News via email. “Fortunately, the children appear to be healthy.”

Long-term follow-up with these children is essential as keeping them healthy is a priority, he emphasized.

Lovell-Badge noted that the donor DNA’s contribution is minimal, asserting that the child will not exhibit characteristics from the women who provided the healthy mitochondria. The donor genetic material constitutes less than 1% of the DNA in babies conceived using this technology.

“In comparison, if you received a bone marrow transplant from a donor, you would possess significantly more DNA from other individuals,” he explained.

In the UK, all couples seeking childbirth via donated mitochondria must obtain approval from the national fertility authority.

Concerns have been raised by critics, who warn that the long-term effects of such innovative techniques on future generations remain uncertain.

“At this time, clinical application in the US is not allowed, mainly due to regulatory restrictions regarding genetic modifications to embryos,” Dr. Williams from Columbia said via email. “Whether this situation will evolve remains unclear and is subject to ongoing scientific, ethical, and policy discussions.”

For almost ten years, Congress has included provisions in the annual funding bill that prevent the FDA from accepting applications related to clinical research protocols involving the intentional creation or modification of human embryos to incorporate genetic alterations.

However, in jurisdictions where such methods are allowed, advocates argue they can offer a promising option for some families.

Liz Curtis, whose daughter Lily passed away from mitochondrial disease in 2006, is collaborating with other families affected by these disorders. She expressed the devastation of receiving a diagnosis indicating that death was inevitable for an infant without intervention.

Curtis reflected on how the diagnosis “turned our world upside down, and yet there was minimal discussion about it, what it entailed, and how it would affect Lily.” Following this experience, she founded the Lily Foundation in her daughter’s honor to raise awareness and support regarding the disease, alongside her latest initiatives at Newcastle University.

“This development is incredibly exciting for families who have little hope for a positive outcome,” Curtis remarked.

The UK fertility authority, which oversees human fertilization and embryology, endorsed the findings, noting that this technique might only be accessible to individuals with a high risk of transmitting disease to their children.

As of this month, 35 patients have been approved to undergo the procedure.

Source: www.nbcnews.com

Fig Trees Could Help Combat Climate Change by Transforming Carbon Dioxide into Stone

Fig trees may excel at reducing carbon dioxide levels in the atmosphere

Raimund Link/Mauritius Images Gmbh/Alamy

Certain fig trees have the ability to transform significant quantities of carbon dioxide into solid forms, allowing carbon to remain in the soil even after the tree has perished. This indicates that fig trees used for timber or fruit cultivation could offer additional environmental benefits through this carbon sequestration process.

While all trees generally utilize carbon dioxide from the air, most of it is converted into structural molecules such as cellulose. However, some tree species also synthesize a crystalline substance known as calcium oxalate, and the bacteria within the trees and soil can convert it to calcium carbonate, a primary component of rocks like limestone and chalk.

Mineral carbon can remain in the soil significantly longer than organic matter derived from wood. Trees that store carbon in this manner include iron syrup (Milisia Excelsa), which is found in tropical Africa and is valued for its wood yet does not yield edible fruit.

Recently, Mike Rory from the University of Zurich and his team discovered that three fig species indigenous to Samburu County, Kenya, can also produce calcium carbonate through their own processes.

“Most trees generate calcium carbonate within the soil,” Laurie explains. “We [also] observe that high concentrations can transform the entire root structure into calcium carbonate in the soil, which is a remarkable finding.”

The research team initially identified the calcium carbonate-generating fig species by using a weak hydrochloric acid solution to detect its release from calcium carbonate. Subsequently, they could confirm the presence of calcium carbonate in the surrounding soil and analyze wood samples to pinpoint where calcium carbonate was being generated.

“What genuinely astonished me was how deep I was digging for [calcium carbonate],” Laurie remarked, as he presented his findings at the Goldschmidt conference in Prague, Czech Republic, this week.

Further investigations are needed to estimate the total carbon storage of these trees, the resilience of water in various climates, and the water requirement. Nevertheless, if fig trees can be integrated into future planting initiatives, they could serve as both a source of nourishment and a carbon sink, according to Laurie.

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Source: www.newscientist.com

Thousands of UK University Students Use AI to Combat Fraud

In recent years, a substantial number of university students in the UK have been identified for misusing ChatGPT and similar AI tools. While traditional forms of plagiarism appear to be declining significantly, a Guardian investigation reveals concerning trends.

The investigation into academic integrity violations has indicated a rise to 5.1 cases per 1,000 students, with nearly 7,000 verified instances of fraud involving AI tools reported between 2023 and 2024. This marks an increase from just 1.6 cases per 1,000 students in the previous academic year, 2022-23.

Experts anticipate these figures will increase further this year, estimating potential cases could reach around 7.5 per 1,000 students, although reported cases likely reflect only a fraction of the actual instances.

This data underscores the rapidly changing landscape for universities as they strive to update evaluation methods in response to emerging technologies like ChatGPT and other AI-driven writing tools.

Before the advent of generative AI in the 2019-20 academic year, plagiarism accounted for nearly two-thirds of all academic misconduct. Plagiarism rates surged during the pandemic as many assessments transitioned online. However, with advances in AI tools, the character of academic fraud has evolved.

Predictions suggest that for the current academic year, confirmed instances of traditional plagiarism could decrease from 19 per 15.2 to 15.2, falling to approximately 8.5 per 1,000 students.

A set of charts displaying verified fraud cases per 1,000 students. Plagiarism is expected to rise from 2019-20 to 2022-23 and then revert, while AI-related fraud is anticipated to rise from 2022-23 to a level comparable to plagiarism. “Other fraud” shows stability.

The Guardian reached out to 155 universities via the Freedom of Information Act, which mandates disclosure of confirmed cases of academic misconduct, including plagiarism and AI-related fraud over the past five years. Out of these, 131 responded; however, not all universities had comprehensive records of annual or fraud categories.

More than 27% of responding institutions did not categorize AI misuse as a distinct form of fraud in 2023-24, indicating a lack of acknowledgment of the issue within the sector.

Numerous instances of AI-related fraud may go undetected. A survey by the Institute for Higher Education Policy revealed that 88% of students admitted to utilizing AI for evaluations. Additionally, last year, researchers at the University of Reading tested their rating system and found that AI-generated submissions went undetected 94% of the time.

Dr. Peter Scarf, an associate professor of psychology at the University of Reading and co-author of the research, noted that while methods of cheating have existed for a long time, the education sector must adapt to the challenges posed by AI, creating a fundamentally different issue.

He remarked, “I believe the reality we see reflects merely the tip of the iceberg. AI detection operates differently from traditional plagiarism checks, making it almost impossible to prove misuse. If an AI detector indicates AI usage, it’s challenging to counter that claim.”

“We cannot merely transition all student assessments to in-person formats. Simultaneously, the sector must recognize that students are employing AI even if it goes unreported or unnoticed.”

Students keen to avoid AI detection have numerous online resources at their disposal. The Guardian found various TikTok videos that promote AI paraphrasing and essay writing tools tailored for students, which can circumvent typical university AI detection systems by effectively “humanizing” text produced by ChatGPT.

Dr. Thomas Lancaster, a researcher of academic integrity at Imperial College London, stated, “It’s exceedingly challenging to substantiate claims of AI misuse among students who are adept at manipulating the generated content.”

Harvey*, who has just completed his Business Management degree at Northern University, shared with the Guardian that he utilized AI for brainstorming ideas and structuring tasks while also incorporating references, noting that many of his peers have similarly engaged with these technologies.

“When I started university, ChatGPT was already available, making its presence constant in my experience,” he explained. “I don’t believe many students use AI simply to replicate text. Most see it as a tool for generating ideas and inspiration. Any content I derive from it, I thoroughly rework in my style.”

“I know people who, after using AI, enhance and adapt the output through various methods to make it sound human-authored.”

Amelia*, who has just completed her first year in a music business program at a university in the southwest, also acknowledged using AI for summarization and brainstorming, highlighting the tool’s significant benefits for students with learning difficulties. “A friend of mine uses AI for structuring essays rather than relying solely on it to write or study, integrating her own viewpoints and conducting some research. She has dyslexia.”

Science and Technology Secretary Peter Kyle recently emphasized to the Guardian the importance of leveraging AI to “level the playing field” for children with dyslexia.

It appears that technology companies see students as a key demographic for their AI solutions. Google is now providing free upgrades to university students in the US and Canada for 15 months to its Gemini Tools.

Lancaster stated, “Assessment methods at the university level may feel meaningless to students, even if educators have valid reasons for their structure. Understanding the reasons behind specific tasks and engaging students in the assessment design process is crucial.”

“There are frequent discussions about the merits of increasing the number of examinations instead of written assessments, yet the value of retaining knowledge through memorization diminishes yearly. Emphasis should be on fostering communication skills and interpersonal abilities—elements that are not easily replicable by AI and crucial for success in the workplace.”

A government spokesperson stated that over £187 million has been invested in the national skills program, with guidelines issued on AI utilization within schools.

They affirmed: “Generative AI has immense potential to revolutionize education, presenting exciting prospects for growth during transitional periods. However, integrating AI into education, learning, and assessment necessitates careful consideration, and universities must determine how to harness its advantages while mitigating risks to prepare for future employment.”

*Name has been changed.

Source: www.theguardian.com

Defending Against the Threat: How UK Banks Combat Cyber Attacks

For bank leaders, it’s their worst nightmare. Urgent communications have rapidly unleashed turmoil across the UK’s financial sector, as cyberattacks incapacitate IT infrastructures.

Bank executives recognize that their stakes are particularly high, especially as family names in other sectors, like Marks & Spencer, grapple with the repercussions of such breaches.

Within hours of a bank breach, millions of direct debits might fail, jeopardizing rent, mortgages, and salaries. Online banking access may be blocked, cash withdrawals denied, and commuters stranded as buses and gas stations refuse payments. News of such an attack often incites panic, prompting rival banks to react and customers to withdraw their funds in anticipation of disruptions.

While this may seem extreme, a well-executed cyberattack on a major UK bank is not far removed from the government’s “rational worst-case scenario.” The financial sector, categorized as one of the 14 “critical national infrastructure” sectors, is particularly vulnerable. Highlighted in the National Risk Register, it models the most significant threats confronting the UK.

This spring, billions of pounds were invested to prevent catastrophic incidents involving major retailers like Harrods, The Co-op, and M&S.

“The financial commitment will be substantial,” Ian Stuart, CEO of UK HSBC, mentioned to MPs last month. “We are under constant attack,” he added.


Following the cyberattack, M&S was compelled to halt online orders for six weeks. Photo: Yui Mok/Pa

According to Stuart, HSBC alone needs to invest hundreds of millions to bolster their security. “This represents our largest expenditure.”

Globally, banks are projected to dedicate 11% of their IT budgets to cybersecurity by 2025, as indicated by an EY survey. This budget is expected to reach $290 billion (about £21.4 billion). By December, banks may invest $32 billion in cybersecurity, according to Celent’s research.

Cybercriminals represent a new kind of threat in the banking sector, evolving from masked robbers targeting physical branches to state-sponsored hackers and independent cybercriminals aiming for ransom or widespread chaos.

“Banks likely comprehend risk more profoundly than many other industries, investing significantly more in security,” states Stuart McKenzie, managing director at Mandiant Consulting, a Google-owned cybersecurity firm that collaborates closely with various UK lenders.

Last month, the Governor of the Bank of England shared with the BBC that cybersecurity risks remain ever-evolving. “We are contending with adversaries who continually enhance their methods of attack, which I must remind the agency to prioritize,” said Andrew Bailey.

However, safeguarding systems is complex. Many high street banks operate on multi-layered IT architectures with numerous updates and add-ons. Incorporating third-party software and cloud services complicates matters further, leading to a convoluted system.

“We refer to it as the offensive side,” remarked Alan Woodward, a cybersecurity expert and professor at the University of Surrey. “The attack surface is expanding, resulting in more chances for attackers to exploit vulnerabilities.”

Historically, successful bank hacks have not been destructive enough to halt the economy completely. Instead, hackers typically target customer data and account information.

In 2021, a hacker from Morgan Stanley accessed personal information belonging to a corporate client by breaching a server operated by third-party consultancy firms.

Earlier, at the onset of the COVID-19 pandemic, an attacker compromised a staff email for the Italian bank Monte Dei Paschi, sending a client a voicemail with malicious attachments.


In 2016, hackers guessed bank card details from over 9,000 Tesco Bank accounts, managing to steal nearly £2.5 million. Photo: Murdo Macleod/The Guardian

Notably, one of the worst hacking incidents in UK banking occurred in 2016, where criminals speculated on card details, leading to the theft of approximately £2.5 million from Tesco Bank accounts. In the aftermath, Tesco had to stop all online and contactless transactions to mitigate fraudulent activity occurring globally, including in Spain and Brazil.

In the end, Tesco Bank fully refunded its customers.

The National Cyber Security Center advises customers who suspect a breach to reach out to their banks through official websites or social media channels, avoiding any links or contact details shared in suspicious communications. Organizations should be able to confirm the status of the breach and provide guidance on next steps.

Since 2013, the Bank of England has actively recognized cybersecurity as a financial stability risk and initiated supervision of cyber resilience standards for all regulated banks and insurance firms.

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The initiative includes the launch of CBEST, the first global program where ethical hackers evaluate the potential vulnerabilities of banks using advanced attack techniques.

“Nothing is absolutely secure,” emphasized Woodward, but he noted that the UK banking system is nearing that goal. “Much of this stems from oversight,” particularly by the central bank, which gathers intelligence from MI5, GCHQ, and NCSC, and conducts real-world scenarios to assess bank resilience.

Every two years, the central bank orchestrates the Multiday Cyberwar game as part of the Simex-Simulation Exercise program, assessing the security of businesses in London.

Additionally, authorities have been scrutinized, with banks, financial regulatory bodies, the Treasury, and the National Cybersecurity Centre evaluating their preparedness for various catastrophic incidents.

Regulators don’t just review bank defenses; they also encourage banks to develop response and recovery plans to mitigate long-lasting disruptions caused by potential cyberattacks, as it’s crucial for their success.

The Cross Market Business Continuity Group, connecting regulators with representatives from UK Finance in the banking sector, boasts the capability to convene approximately 100 firms for emergency discussions within an hour during potential threats.

Avoiding breaches is deemed essential for safeguarding industries that ultimately rely on trust. Customers expect banks to protect their data, incomes, and life savings from outside threats.

“If anyone can breach that security and execute a fraudulent transaction… you will lose trust in that bank, right?” remarked Woodward.

Banks have already faced backlash from mere IT disruptions, even without malicious intent aiming to undermine the banking system or steal sensitive information.

TSB has spent years rehabilitating its image after the IT collapse in 2018, caused by a failed separation from Lloyds’ internal systems, which led to millions of customers being locked out of their accounts for weeks. The bank was subsequently fined £48 million for “serious and widespread” failures.


TSB has been diligently working for several years to restore its standing following the 2018 IT crisis. Photo: Andrew Matthews/PA

Data gathered by the Parliamentary Treasury Committee indicates that the repercussions continue to affect some of the UK’s largest banks and their client bases, with significant IT failures over an extended period between January 2023 and February 2025.

“Customer money and data security are paramount for banks, not only due to regulatory demands but also as a cornerstone of their business model.”

“While I don’t dismiss the potential for cyber incidents, I remain confident in the level of cyber defense we maintain.”

Source: www.theguardian.com

Revolutionary Anti-Venom Solutions Combat the World’s Most Lethal Snakes

Treatment offers protection to mice against venom from common taipans and various other snakes

Matthijs Kuijpers/Alamy

Antibodies derived from inflammatory men exhibit effectiveness against a range of snake bites, suggesting that a universal treatment may soon be achievable.

Annually, snake bites result in the deaths of as many as 137,000 individuals. In addition, there are reported cases of significant complications. Currently, anti-venoms are being manufactured for individual snake species using antibodies sourced from sheep.

The use of non-human antibodies, however, can lead to serious adverse effects, including potentially fatal allergic reactions. Additionally, it necessitates the identification of the specific snake responsible for the bite before administering the anti-venom.

Jacob Granville from Centivax, a biotechnology firm in San Francisco, California, is exploring broadly neutralizing antibodies that could be developed into anti-venoms effective against multiple or all venomous snakes. “There are 650 venomous snake species, but their venoms involve just 10 common classes of toxins,” Granville explains.

Researchers began investigating individuals bitten multiple times by different snakes. “Perhaps a daring snake researcher,” remarks Granville. Media reports introduced the story of Tim Friede, who claims to have “self-administered escalating doses of venom from the world’s deadliest snakes over 700 times.”

“If anyone could yield a wide-ranging neutralizing antibody against snake venom, it would be Tim Friede,” Granville affirms.

From just 40 milliliters of Friede’s blood, the team “converted immune memory into a library of billions of antibodies,” he adds. They subsequently tested promising candidates against venom from 19 of the deadliest Elapidae family species, including several cobra varieties.

Ultimately, they treated two antibodies derived from Friede’s blood, known as LNX-D09 and SNX-B03, along with a toxin inhibitor named varespladib. In experiments on mice, this combination provided comprehensive protection against 13 species, including various cobras, the tiger snake (Notechis scutatus), and the general Thai bread snake (Oxyuranus scutellatus). It also offered partial protection against six additional species, including the notorious death adder (Acanthophis Antalcus).

The subsequent phase involves testing these treatments on animals brought into Australian veterinary clinics following a snake bite and identifying antibodies that can confer protection against vipers.

Tian Du from the University of Sydney emphasizes that “discovering two antibodies that can inhibit toxins makes for a universal treatment for closely related species.”

Additionally, after learning that the anticoagulant drug heparin can assist individuals in avoiding limb loss following a cobra bite, Du aims to determine whether their treatment can also avert skin and muscle necrosis.

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Source: www.newscientist.com

Washington’s Turmoil Hinders Efforts to Combat Avian Flu

Interviews with over a dozen scientists and federal officials reveal that the initiative to control bird flu on farms has been hindered by a tumultuous administration transition, which prioritized cost-cutting, reduced federal employment, and limited communication.

On one poultry farm alone, more than 168 million birds were culled to mitigate the outbreak. The virus, first identified in American dairy cows about a year ago, has spread to 17 states and is increasingly prevalent. A flock of 1,000 birds was affected.

In the early months, the Trump administration dismissed a team of scientists crucial for tracking the virus’s spread, canceling significant meetings and limiting data access for federal scientists.

The Department of Health and Human Services has not held a public briefing on bird flu since January and has not responded to inquiries for comments.

Health Secretary Robert F. Kennedy Jr. suggested letting the virus spread unchecked among poultry to distinguish vaccinated birds, an idea supported by Democratic lawmakers. This opened the survey into the federal response.

The Trump administration also removed funding for the Food and Agriculture Organization’s program, a UN body responsible for monitoring and controlling avian flu in 49 countries.

“We’ve noted considerable challenges,” highlighted Lindsay Mar, a specialist in airborne viruses at Virginia Tech.

“Animals and people provide strong warning signs. Yet we merely observe them and fail to act,” she remarked.

Avian influenza has impacted various mammal species, including 150 cats, with at least 70 cases across 26 states resulting in four hospitalizations and one death. Following the winter lull, the spring travel season has reignited the infection rates.

In the past 30 days, the Ministry of Agriculture has reported 47 new infectious cases across three states.

Currently, the H5N1 virus does not seem capable of human-to-human transmission. Nonetheless, a recent mutation appears to be edging closer to that possibility.

This week, an international group of virologists concluded that continuous monitoring of milk from dairy farms, wastewater, and individuals working with infected animals is vital.

Authorities are testing bulk milk to help identify infected herds. However, the agricultural sector’s strategy to counter bird flu is currently focused on lowering egg prices, with little mention of dairy cows.

Agriculture Secretary Brooke Rollins has proposed enhancements to farm biosecurity to assist farmers in ten states in curbing the virus’s spread on their premises.

“The initial emphasis of these ongoing efforts will be on egg-soaking facilities as part of USDA’s coordinated strategy to tackle egg prices, but we anticipate the inclusion of other poultry and dairy producers as the program expands,”

An early wave of federal layoffs impacted a veterinarian in the avian flu-focused agriculture sector, leading to both terminations and rehiring. Today, many continue to manage government-issued credit cards with restrictions that complicate travel and procurement of necessary supplies without seeking extended credit.

The Agriculture Department defended its policies, stating, “The restrictions on government-issued credit cards will automatically relax once personnel obtain travel approval,” according to a department spokesperson via email.

On April 1, the Trump administration dismissed veterinarians and scientists at the Food and Drug Administration investigating raw pet food contaminated with H5N1, which had adversely affected cats, and was pivotal in assisting veterinarians in developing proposals for vaccines and treatment of infected animals.

According to an anonymous official fearing retaliation, the CDC has begun withholding genetic analyses of virus samples collected from patients. Even some internal teams can no longer access this information.

Typically, federal agencies release data 242 days post-collection, as revealed by a recent analysis. Ideally, this process should only take a few weeks, according to scientists. Such delays complicate the tracking of the virus’s spread and accurate assessment of risks to the public.

Significant reports in the agency’s publications, such as weekly morbidity and mortality records, have been affected, mentioned the former anonymous official.

In February, instead of the scheduled reports on avian flu infections in domestic cats, agency scientists were instructed to prioritize a paper on the impact of LA wildfires on air quality.

While research on avian flu emerged weeks later, agency staff expressed their discontent with the delayed directives from superiors.

The Biden administration has been holding regular inter-departmental calls on avian flu, involving numerous external experts and state health officials, to share the latest findings. These discussions have been diminished, much like the CDC’s guidance on monitoring.

All communication from the CDC requires clearance from federal health officials in Washington. The agency has not held an avian flu press conference since January.

“There have been numerous health challenges,” remarked Dr. Adam Rowling, a virologist and infectious disease specialist at the University of Michigan.

The nation retains stockpiles containing millions of doses of human vaccines against avian influenza. However, amid budget cuts, agencies responsible for these stockpiles and rapid emergency distribution have shifted under the CDC.

Dawn O’Connell, who leads the administration for strategic preparation and response, an agency that has maintained its stockpile under the Biden administration, noted that this shift would “add a layer of bureaucracy instead of removing it.”

In interviews, several employees from the CDC and agricultural sector expressed low morale, worsened by successive layoffs. During a City Hall gathering on April 16, around a quarter of the veterinarians present indicated they would consider signing onto a deferred resignation program that offers full pay and benefits until September 30th.

Over the past year, it has been challenging to monitor cows infected with H5N1. They exhibited fever and produced thick yellow milk, with some cows suffering voluntary abortions.

However, reinfections have been found in cows, with second-round symptoms being subtle, complicating the identification of infected cows and protecting those who interact with them. Currently, rapid testing for the virus in cattle and humans is unavailable.

Reinfection indicates that the virus may permanently colonize dairy cows. Meanwhile, the virus continues to circulate among wild birds, evolving approximately twice as fast in birds as in cows.

A new variant, known as D1.1, which is believed to cause more severe illness, emerged in September and quickly became the dominant strain. The government’s response has not matched this rapid evolution.

In Nevada, milk samples collected on January 6th and 7th tested positive for avian influenza by January 10th. Ideally, the 12 farms contributing these samples would have been quarantined while confirming results.

Instead, further samples were gathered on January 17th, with results confirmed a week later.

The Agriculture Department stated that delays in test results would not impede the outbreak response. “It is crucial to note that response activities operate independently of the sequence of the results and occur as needed,” the department claimed.

Michael Warby, an evolutionary biologist at the University of Arizona, expressed skepticism, noting, “This appears to be a situation where the barn door is closed after the cows have escaped.”

He suggested that it’s still feasible to eradicate the virus on American farms if the Agriculture Bureau enhances containment measures.

For instance, a rapid testing method that detects H5N1 in bulk milk could provide officials with more time to eliminate outbreaks, compared to tests that yield results after several weeks.

“We believe this is a goal to pursue unless it proves futile,” Dr. Warby commented regarding the virus’s expulsion.

At present, removing the virus from farms is not straightforward.

For example, if an infected duck flies over a farm and defecates, an outbreak could commence among millions of birds. Farmers may inadvertently transport remains into chicken coops, and infected rodents can enter through small openings.

Chickens are densely packed and have weak immune systems; a single sneeze can quickly infect hundreds or even thousands.

Over the past two years, the Agriculture Department has collaborated with egg producers in four states: Iowa, Minnesota, South Dakota, and North Dakota.

Federal officials have assisted in identifying and removing surrounding wildlife, including mice, and have eliminated potential virus entry points that farmers might overlook. Notably, only two out of 108 facilities involved in the pilot program reported subsequent virus outbreaks.

This project is slated to expand this year to ten states, including California, Texas, Ohio, and Pennsylvania, with plans to reach all 50 states by 2027. Agricultural experts aim to help farmers identify even the smallest vulnerabilities against avian flu.

While this proposal has garnered praise from scientists, some experts, including veterinarians in agriculture, are uncertain about its implementation.

Department staff have been striving to combat bird flu since early 2022. There is already an insufficient workforce to detect facility weaknesses necessary for farm operation and readiness for reopening.

“We’ve been working continuously for three years, leading to increasing fatigue among staff,” noted a veterinarian who requested anonymity without permission to engage with the media.

Given the current situation on farms, even stringent measures may not suffice to bar the virus, remarked Andrew Decoriolis, executive director of Advocacy Group Farm Fight.

“The outbreak is likely to persist until the industry undergoes significant transformation,” he remarked.

Source: www.nytimes.com

NASA’s Budget Cuts Endanger Wildfire Combat Program

Hinesville, Ga. — From an elevation of 9,000 feet, NASA researchers observed extensive areas of prescribed burns at Fort Stewart Army Base this month, actively monitoring the flames and engaging with the landscape.

This burn is intentional and controlled, conducted as part of “prescription burns” to clear specific regions. The study, part of NASA’s FireSense project, aids firefighters in combating actual wildfires and may even help land managers avoid unnecessary ignitions.

However, initiatives like FireSense may face challenges as reports suggest significant budget cuts for NASA and other federal agencies under the Trump administration.

Last year, the U.S. experienced nearly 9 million acres consumed by wildfires, according to the National Interagency Fire Centre. Their annual report noted that wildfires and burned acreage in 2024 were “significantly higher than the five- and ten-year averages.”

Research indicates that climate change not only increases the frequency of wildfires but also exacerbates their destructiveness.

“The situation is deteriorating,” stated Michele Steinberg, director of the Wildfire Division at the National Fire Prevention Association. “We are witnessing fires in areas previously unaffected, burning hotter than ever.”

Severe wildfires pose substantial health, financial, and environmental threats, highlighting the importance of safeguarding lives and livelihoods through research.

NASA is not the only agency focused on wildfire issues. The U.S. Forest Service, the Department of the Interior, and the Bureau of Land Management are among the key federal entities engaged in wildfire response and prevention. What sets space agencies apart is their application of advanced technologies, including tools used in space, to bridge existing knowledge gaps.

“FireSense emerged from NASA’s recognition of wildfires as a significant issue. We are leveraging our expertise to assist the government in improving its wildfire management efforts.”

Project scientists will collaborate with local, state, and federal agencies, as well as academic partners, to enhance understanding of fire behavior, air quality concerns during and after wildfires, and ecosystem recovery post-ignition. Researchers are also exploring ways to manage vegetation in at-risk areas to minimize wildfire risks and curb rapid spread.

“Our objective is to adopt innovative technology, work closely with Wildland Fire Managers, and ensure this technology is accessible for wildfire situations,” explained Jacquelyn Shuman, a NASA Firesense project scientist.

The project employs equipment designed similarly to instruments used in low-Earth orbit on the International Space Station, providing detailed and accurate metrics to assist firefighters and land managers before, during, and after major fires.

At Fort Stewart, scientists monitored the prescribed burns, documenting the spread and mapping the flames with advanced infrared instruments known as Aviris-3 (short for Airborne Visible/Infrared Imaging Spectrometer 3). The fire ultimately consumed around 700 acres.

NASA scientists are studying prescribed burns at Fort Stewart on April 14th.
Milan P. Leikono / NASA

Researchers closely monitored fire spread, its ground position, and temperature variations.

Prescription burns are intentionally ignited to manage ecosystems that rely on regular fires for health. They also help diminish dry, combustible vegetation that could ignite uncontrollably.

These burns are meticulously planned and conducted under specific weather conditions to control their spread; they also serve as scientific experiments for wildfire researchers, according to Harrison Raine, a former elite firefighter and current project coordinator for FireSense.

“We’re aiming to integrate all aspects of the fire lifecycle and utilize scientific understanding to address ongoing issues,” said Raine, who has extensive wildfire experience across multiple states.

“This is a profoundly personal issue for me,” he shared. “Coming from Los Angeles, I’ve witnessed the devastation firsthand, and I am committed to tackling this critical challenge. It requires all available tools, and science is crucial.”

NBC News correspondent Jacob Soborov (left) visits FireSense burns with Department of Defense employees.
Milan P. Leikono / NASA

Nevertheless, the future of FireSense may be uncertain due to ongoing concerns regarding funding for NASA and other federal programs.

While the budget cuts could impact project viability, the precise effects remain unclear. Signals indicate significant reductions to NASA’s Science Mission Bureau, which includes geoscience initiatives.

“Funding decisions have not yet been finalized,” stated Rachel Courley, a spokesperson for the White House Office of Management and Budget. NASA declined to comment and referred questions about the budget to OMB.

As the administration gears up to unveil its budget proposals shortly, concerns about possible cuts intensify.

“As a former NASA leader, I take pride in the agency’s comprehensive efforts to monitor and respond to wildfires,” remarked Sen. George Whiteside (D-Calif) in a statement. “Cutting essential wildfire programs like FireSense poses a risk to rebuilding communities like mine after devastating fires in Southern California.”

Stanford University’s Wara emphasized the far-reaching consequences of NASA’s wildfire research, noting that space agencies have significantly contributed to contemporary wildfire models and fire-related data.

“There’s no doubt that FireSense has considerably enhanced our understanding of fire behavior and risk,” he commented. “Losing this initiative would be detrimental, as regaining that knowledge is exceedingly challenging.”

Source: www.nbcnews.com

British companies recommend conducting video and face-to-face interviews to combat North Korean employment scams.

British companies are being advised to conduct job interviews via video or in-person to avoid the risk of inadvertently hiring North Korean employees.

The caution comes after analysts noted that the UK has become a prime target for misinformed IT workers recruited by North Korea. These individuals are typically hired to work remotely, evade detection, and funnel earnings back to Kim Jong-un’s regime.

In a recent report, Google revealed an incident from last year involving a lone North Korean operative, with at least 12 aliases operating across Europe and the US. These IT workers were seeking positions in defense and government sectors. The new tactic involves fake IT professionals threatening to leak sensitive company data post-termination.

John Hultquist, chief analyst at Google’s Threat Intelligence Group, highlighted North Korea’s shift towards Europe, particularly targeting the UK.

He explained, “North Korea is feeling the heat in the US and has shifted its focus to the UK to expand its IT worker tactics. The UK offers a broad spectrum of businesses in Europe.”

Fraudulent IT worker schemes typically involve individuals with a physical presence in countries aided by “facilitators” or agents of North Korea.

These facilitators play crucial roles like providing fake passports and maintaining local addresses. Laptops used by these individuals often connect to servers in Pyongyang, not their current location. However, they seek jobs that offer unique devices for easier monitoring.

“Ultimately, having a physical presence in the UK is key to their expansion strategy across various sectors in the country,” mentioned Hultquist.

Hultquist suggested that conducting job interviews in-person or via video could disrupt North Korea’s tactics.

Sarah Kern, a North Korean specialist at cybersecurity firm SecureWorks, emphasized that the threat is more widespread than perceived by companies.

She recommended thorough candidate screening and HR education on deception tactics. Companies should prioritize in-person or video interviews to verify the legitimacy of potential employees.

“In the US, conducting in-person or video interviews to verify candidates’ background details is effective in ensuring you’re engaging with truthful candidates,” she added.

Kern noted that IT workers may propose unconventional methods like frequent address changes or the use of money exchange services over traditional bank accounts.

Bogus IT experts are infiltrating Europe through online platforms like Upwork, Freelancer, and Telegram. Upwork stated that attempts to use false identities go against their terms of service, and they take strict action to remove such individuals.

As pointed out by Kern, North Korean IT workers often try to avoid video interviews, likely due to their working conditions in cramped spaces resembling call centers.

Source: www.theguardian.com

State and energy experts unite in new debate to combat federal budget cuts

Scientists, lawmakers, and energy executives have warned that President Trump’s “energy control” agenda will be compromised by abrupt cuts in federal agencies reportedly planned by the Trump administration. Pleas from various quarters have inundated the Cabinet Secretary’s inbox urging them to preserve different departments of the agency. A deadline looms for federal officials to present a new plan for significant budget cuts today, with energy and environment-related agencies expected to bear the brunt.

Experts have cautioned that cuts to the Environmental Protection Agency, the Department of Interior, and the Department of Energy would severely impact efforts to combat climate change. Unfortunately, there seems to be little hope that these concerns will be heeded by Trump administration officials who either deny or disregard the threat of global warming. Instead, the proposed job cuts align with the administration’s priorities, arguing that the cuts jeopardize the expansion of nuclear energy, mineral production, and energy accessibility.

The Department of Energy is expected to face significant losses, particularly in programs like the Clean Energy Demonstration overseeing major projects such as plans to establish seven hydrogen hubs nationwide. Another target is the Loan Program Office, which provides federal funding for clean energy initiatives.

A coalition of energy producers and trade groups representing various sectors like nuclear, data centers, wind and solar energy, and carbon dioxide removal technology expressed concerns that the proposed cuts jeopardize America’s energy and industrial strategies. They highlighted critical projects such as the loan office’s funding for a new nuclear power plant, major lithium mining projects in Nevada, and grid upgrades in Arizona and the Midwest to meet increasing electricity demand from manufacturing.

Additionally, 20 former commissioners and directors of state environmental agencies raised alarm over reports that the EPA intends to eliminate its Scientific Research Division and Research and Development Agency.

EPA administrator Lee Zeldin has announced plans to slash the agency’s budget and workforce by approximately 65%. State officials criticized these cuts, stating that they would hinder the agency’s ability to conduct essential research and uphold its regulatory responsibilities.

They emphasized the pivotal role of the EPA’s science department in addressing issues like PFA removal from drinking water and developing technologies for cleaning toxins from environmental sites.

Democrats on the House Energy Commerce Committee expressed concern over the impact of what they described as “mass cuts” at the EPA. They warned that targeting professional civil servants would endanger public health and impede the agency’s mission to protect human health and the environment.

Reports indicate that thousands of government employees have already resigned, including personnel from agencies like the National Park Service and the Bureau of Land Management. The anonymity was requested to disclose details of the resignations that have not been publicly disclosed by the administration.

Source: www.nytimes.com

Prosecutors urged to step up efforts to combat revenge porn and protect victims from abusers depicted in images online

The Crown Prosecutor’s Office is planning to update its guidance on “revenge porn” crimes to ensure that explicit photos of the victim are no longer allowed to be retained.

observer reported last month that the Magistrates’ Court did not order the removal of content related to Image-based abuse cases, and prosecutors did not request such action.

An examination of court records revealed that out of 98 cases, only three resulted in deprivation orders requiring offenders to surrender their devices and delete private photos and videos.

In one case, a man was accused by a magistrate of engaging in “deeply disturbing” behavior to emotionally intimidate the victim. Despite receiving a suspended sentence, no order was issued to have him surrender his device for deletion, leaving the police without the legal authority to do so.

These findings prompted outcry from activists, demanding immediate action and stating that the failure to act left victims “living in fear.” The CPS acknowledged the need for more action to prevent these images from being used to perpetrate further crimes.

The prosecutor’s guidance on communication crimes is currently being revised. The new guidelines, released this week, urge prosecutors to utilize deprivation orders more effectively and consistently.

Prosecutors are advised to consider implementing the order early in their case strategies to strip offenders of their devices promptly and foster a more uniform approach to device confiscation from suspects from the outset.

Campaigners welcomed the change as a positive step forward.

Elena Michael from the campaign group #notyourporn commended the guidance as a helpful step but emphasized the need for further actions to be taken.

She highlighted additional areas for improvement, such as addressing issues related to evidence collection and advocating for a more comprehensive investigation process.

Furthermore, she urged clarity on whether the guidance would extend to hard drives, cloud storage, and physical devices in addition to mobile phones.

Law professor Claire McGlyn praised the updated guidance as a positive development and a step towards progress, emphasizing the importance of addressing image-based sexual abuse cases more effectively.

The Judgment Council, responsible for issuing guidance to judges and magistrates, stated that they are monitoring the government’s new intimate image law proposal and will consider necessary adjustments to guidelines once it is enacted.

Source: www.theguardian.com

New Therapies on the Horizon to Combat Autoimmune Diseases

Pere Santamaria was 15 years old when she developed myasthenia. This autoimmune condition can cause extreme muscle weakness and sometimes lead to difficulty breathing. In Santa Maria's case, it affected the muscles in the eye that controlled his vision, causing him to look double.

“It personally had a huge impact on me,” he says. “I was in adolescence and suddenly I couldn't play sports and couldn't live a normal life. I had to take very high doses of corticosteroids, so I was able to have balloons. It's inflated like that.”

Worse, these drugs simply attenuate the body's general immune response, rather than addressing the causes of autoimmune. In other words, Santa Maria did not expect that taking them would cure his condition.

As years went by, Santa Maria developed an additional autoimmune state. “I just wanted to understand the disease and mechanisms, and hopefully I can help others in the end,” he says.

He is now progressing towards that goal. He works as an immunologist at the University of Calgary, Canada. Santa Maria It is at the forefront of pushing to reprogram the immune system and develop new therapies to encourage the human body to end a destructive war against its own organization.

As these treatments move to clinical trials, there are signs of promise. Certainly, some are very effective, so with a single dose, in some cases, people have been symptomatically gone for years. So, is the end of an autoimmune state visible now?

Innate and Adaptive Immunity Systems

Our bodies have several lines of defense against pathogens. …

Source: www.newscientist.com

Artificial intelligence tools employed to combat child abuse imagery in home offices

The United Kingdom has become the first country to implement laws regarding the use of AI tools, as highlighted by a remarkable enforcement organization overseeing the use of this technology.

It is now illegal to possess, create, or distribute AI tools specifically designed to generate sexual abuse materials involving children, addressing a significant legal loophole that has been a major concern for law enforcement and online safety advocates. Violators can face up to five years in prison.

There is also a ban on providing manuals that instruct potential criminals on how to produce abusive images using AI tools. The distribution of such material can result in a prison sentence of up to three years for offenders.

Additionally, a new law is being introduced to prevent the sharing of abusive images and advice among criminals or on illicit websites. Border units will be granted expanded powers to compel suspected individuals to unlock and submit digital devices for inspection, particularly in cases involving sexual risks.

The use of AI tools in creating images of child sexual abuse has increased significantly, with a reported four-fold increase over the previous year. According to the Internet Watch Foundation (IWF), there were 245 instances of AI-generated child sexual abuse images in 2024, compared to just 51 the year before.

These AI tools are being utilized in various ways by perpetrators seeking to exploit children, such as modifying a real child’s image to appear nude or superimposing a child’s face onto existing abusive images. Victim voices are also incorporated into these manipulated images.

The newly generated images are often used to threaten children and coerce them into more abusive situations, including live-streamed abuse. These AI tools also serve to conceal perpetrators’ identities, groom victims, and facilitate further abuse.

Secretary of Technology, Peter Kyle, expressed concerns that the UK must stay ahead of the AI Revolution. Photo: Wiktor Szymanowicz/Future Publishing/Getty Images

Senior police officials have noted that individuals viewing such AI-generated images are more likely to engage in direct abuse of children, raising fears that the normalization of child sexual abuse may be accelerated by the use of these images.

A new law, part of upcoming crime and policing legislation, is being proposed to address these concerns.

Technology Secretary Peter Kyle emphasized that the country cannot afford to lag behind in addressing the potential misuse of AI technology.

He stated in an Observer article that while the UK aims to be a global leader in AI, the safety of children must take precedence.

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Concerns have been raised about the impact of AI-generated content, with calls for stronger regulations to prevent the creation and distribution of harmful images.


Experts are urging for enhanced measures to tackle the misuse of AI technology, while acknowledging its potential benefits. Deleclehill, the CEO of IWF, highlighted the need for balancing innovation with safeguarding against abuse.

Rani Govender, a policy manager at NSPCC’s Child Safety Online, emphasized the importance of preventing the creation of harmful AI-generated images to protect children from exploitation.

In order to achieve this goal, stringent regulations and thorough risk assessments by tech companies are essential to ensure children’s safety and prevent the proliferation of abusive content.

In the UK, NSPCC offers support for children at 0800 1111, with concerns for children available at 0808 800 5000. Adult survivors can seek assistance from Napac at 0808 801 0331. In the United States, contact Childhelp at 800-422-4453 for abuse hotline services. For support in Australia, children, parents, and teachers can reach out to Kids Helpline at 1800 55 1800, or contact Bravehearts at 1800 272 831 for adult survivors. Additional resources can be found through Blue Knot Foundation at 1300 657 380 or through the Child Helpline International network.

Source: www.theguardian.com

Illuminating the clouds: How enhancing brightness can combat climate change

The concept of Marine Cloud Brightening revolves around the idea that by making clouds brighter or whiter, more sunlight is reflected back into space. This ultimately helps reduce the amount of heat absorbed by Earth’s atmosphere and offers a respite from the effects of increased carbon emissions.

Clouds in marine environments are believed to benefit the most from such brightening efforts. But how exactly does one go about brightening clouds, and does it work as effectively as theorized?

Scientists primarily suggest spraying aerosols, such as fine sea salt particles, to brighten clouds. These aerosols act as “condensation nuclei” within the clouds, promoting water vapor to form more liquid droplets and creating denser, brighter clouds. A similar effect can be seen with pollution particles.

Fun fact: Some clouds can contain 500,000 kg (or £ 1.1 million) of water. That’s about 100 elephants -Photo Credit: Getty

However, the challenge lies in ensuring the particles sprayed are of the right size to effectively brighten the clouds at the appropriate time. Additionally, achieving significant sunlight reflection requires scaling up the operation sufficiently. There is also the concern of unforeseen impacts on clouds and climate.

Current research efforts mainly involve small-scale experiments and computer simulations, though some real-world studies have raised questions. For instance, a bright cloud experiment in Arameda, California was halted in May following warnings from local authorities reported in the media.

Experts have suggested that useful insights can be gleaned from “natural” experiments as well. Observations near the Kilauea volcano in Hawaii showed that aerosols generated naturally during the eruption led to a 50% increase in cloud cover.

Ultimately, the decision on whether to pursue large-scale marine cloud brightening rests with policymakers, who require convincing evidence. As scientific understanding and the climate crisis evolve, attitudes may shift.


This article addresses the question (I asked from Besariany Shepherd, Derbyshire) “Is Marine Cloud Brightening useful for fighting climate change?”

To submit a question, please email questions@sciencefocus.com or send a message via our Facebook, Twitter, or Instagram Page (remember to include your name and location).

For fascinating science facts, visit our fun fact page.


Read more:

Source: www.sciencefocus.com

Possible Title: Potential Evidence of ‘Sun Stones’ Used by Ancient Societies to Combat Volcanic Winters

A stone tablet with a sun motif discovered on the Danish island of Bornholm

Antiquity Publications/John Lee, National Museum of Denmark

Hundreds of mysterious carved “sun stones” excavated in Denmark may have been ritually buried after the sun disappeared in a volcanic eruption around 2900 BC.

A total of 614 stone tablets and fragments inscribed with decorative motifs of the sun and plants have been unearthed in recent years. Basagard West Ruins Located on the island of Bornholm in Denmark. They were discovered in geological formations dating back some 4,900 years, when Neolithic people were farming the region and building enclosures surrounded by earthworks of banks and ditches.

Most of the carved sun stones were found in ditches around these enclosures, which were covered with cobblestones containing pottery shards and other items. This pottery is typical of the Late Funnel Beaker culture, which existed in the area from about 2900 to 2800 BC.

It was originally proposed that the stone carving of the sun was buried to ensure a good harvest. They say the sun was central to early Nordic agricultural culture. Rune Iversen at the University of Copenhagen, Denmark.

“But why did they store all these images at the same time?” Iversen asks. “The last thing they basically did here was deposit these sun stones and cover them with animal bone fragments and all kinds of artifacts and stuff like that. And then it went from trench to trench. You can see it being repeated. So it's some kind of action or event.”

Now he and his colleagues have found the answer. They looked at data from ice cores taken in Greenland and Antarctica and found that high concentrations of sulfate were deposited in the years following volcanic eruptions around 2900 BC.

Researchers say the relative proportions of sulfate deposition in Greenland and Antarctica suggest the eruption was somewhere close to the equator, and its effects appear to have spread over a vast area. . Ash clouds may have blocked out the sun and cooled temperatures for years.

A severe cold period around 2900 B.C. is supported by sources such as preserved wood rings from the Main River Valley in Germany and long-lived rock pine tree rings from the western United States.

This eruption would have had a devastating impact on the Neolithic peoples of northern Europe. “If we don’t have a harvest and the crop is not accepted, we won’t be able to sow anything next year,” Iversen says. “They must have felt quite punished at the time, because endless catastrophe was just going to befall them.”

He and his colleagues say burying the sculptures may have been an attempt to bring back the sun, or a celebration after the skies finally cleared.

say “that's a good explanation” jens winter johansen At the Roskilde Museum in Denmark. “There is no doubt that our staunchly agricultural society must trust the sun.”

Lars Larsson Researchers from Sweden's Lund University asked why, if climate impacts are widespread, evidence of such behavior is only found on Bornholm and not elsewhere in southern Scandinavia. Ta.

That may be because the people there had an abundance of slate, a hard stone with which to carve statues of the sun, whereas much of the rest of southern Scandinavia is mostly clay and has fewer stones suitable for carving. The body, Iversen says. “They may have carved wood or leather from other locations,” he says, but these would not normally have been preserved.

Or it may reflect cultural differences, Johansen says. “These societies are not isolated, but they are more isolated on the islands. That may be why they developed their own customs and culture.”

topic:

Source: www.newscientist.com

Environmental organizations gear up to combat incoming Trump administration

overview

  • Environmental groups are gearing up to resist the anticipated policy changes from the incoming Trump administration.
  • They foresee President Trump expanding oil and gas drilling and attempting to undo or scale back some of the legislation passed during Biden’s presidency.
  • Environmental groups are bracing for legal battles ahead and are seeking donations to support their efforts.

Environmental groups are preparing for pushback against the upcoming Trump administration, expecting swift policy changes compared to when Donald Trump took office in 2017.

Based on Trump’s past actions and recent campaign comments, experts predict that he will expand oil and gas drilling, reduce land conservation efforts, and possibly aim to reverse Biden-era legislation like the Infrastructure Investment and Jobs Act and the Curbing Inflation Act.

Environmentalists are concerned about Trump’s Cabinet picks, who are likely to support increased drilling activities as per Trump’s statements. Legal battles are on the horizon, with groups like the Center for Biological Diversity gearing up for potential fights against unlawful changes.

The Brookings Institution reported that Trump’s first administration made around 74 moves that were seen as detrimental to environmental policies, a number that might rise in the next term given Trump’s promise to change regulations significantly.

Environmental groups like NRDC and the Center for Biological Diversity are readying themselves for legal disputes and are actively seeking donations to fund their fight against expected environmental policy changes.

Trump’s transition team has not provided any comments on the matter.

Both NRDC and the Center for Biological Diversity have a track record of successfully challenging Trump’s policies in court, winning a significant percentage of the cases they engaged in.

Conservation groups are anticipating conflicts over protected federal lands, particularly in the Southwest, with past battles over Bears Ears National Monument and Grand Staircase-Escalante National Monument in Utah serving as examples of potential future clashes.

The sun sets over Monument Valley in the distance, seen from Bears Ears National Monument outside Blanding, Utah, in 2021.George Fry/Getty Images File

Source: www.nbcnews.com

Childline Empowers Teens to Combat Financial Sextortion amid Growing Concerns

Recently, ChildLine counselors have been receiving an alarming number of calls regarding a specific issue.

In one case, a 17-year-old boy reached out for help after being blackmailed for sending intimate images to someone he thought was his age. This type of sextortion, driven by financial motives, is becoming more prevalent among UK teenagers.

Childline supervisor Rebecca Hipkiss revealed that these incidents have increased significantly over the past year, with over 100 cases reported. Victims often feel embarrassed and fear the repercussions of having their personal images shared with their friends and family.

Childline, operated by the NSPCC children’s charity, offers a “Report Remove” service to help victims of sexual blackmail take control of their images online. The service creates a digital fingerprint of uploaded images to prevent them from being circulated on major platforms.

With the rise of sophisticated AI tools, teenagers are now facing threats of deepfake content being created using their photos. These fake images are then used to extort money from victims, causing significant distress.

Victims of sex blackmail often feel helpless and worried about the consequences of these incidents. Childline advises them not to pay the scammers and to report the extortion attempts to the authorities.

It’s crucial for teens to be cautious and set boundaries in their online interactions. Understanding the risks and knowing when to say no are essential in protecting themselves from falling victim to such scams.

Source: www.theguardian.com

Utilizing Chatbots to Combat Phone Scammers: Exposing Real Criminals and Supporting True Victims

A scammer calls and asks for a passcode, leaving Malcolm, an older man with a British accent, confused.

“What business are you talking about?” Malcolm asks.

Again, I received a scam call.

This time, Ibrahim, cooperative and polite with an Egyptian accent, answered the phone. “To be honest, I can’t really remember if I’ve bought anything recently,” he told the scammer. “Maybe one of my kids did,” Ibrahim continued, “but it’s not your fault, is it?”

Scammers are real, but Malcolm and Ibrahim aren’t. They’re just two of the conversational artificial intelligence bots created by Professor Dali Kaafar and his team, who founded Apate, named after the Greek goddess of deception, through his research at Macquarie University.

Apetto’s goal is to use conversational AI to eradicate phone fraud worldwide, leveraging existing systems that allow telecommunications companies to redirect calls when they identify them as coming from scammers.

Kafal was inspired to strike back at phone scammers after he told a “dad joke” to the caller in front of his two children as they enjoyed a picnic in the sun. His pointless chatter kept the scammer on the line. “The kids had a good laugh,” Kafal says. “I thought the goal was to trick them so they would waste their time and not talk to other people.

“In other words, we’re scamming the scammers.”

The next day, he called in his team from the university’s Cybersecurity Hub. He figured there had to be a better way than his dad joke approach — and something smarter than a popular existing technology: Lennybot.

Before Malcolm and Ibrahim, there was Lenny.

Lenny is a rambling, elderly Australian man who loves to chatter away. He’s a chatbot designed to poke fun at telemarketers.

Lenny’s anonymous creator posted this on Reddit. They say they created the chatbot as “a telemarketer’s worst nightmare… a lonely old man who wants to chat and is proud of his family, but can’t focus on the telemarketer’s purpose.” The act of tying up scammers is called scamming.

Apate bot to the rescue

Australian telecommunications companies have blocked almost 2 billion scam calls since December 2020.

Thanks to $720,000 in funding from the Office of National Intelligence, the “victim chatbots” could now number in the hundreds of thousands, too many to name individually. The bots are of different “ages,” speak English with different accents, and exhibit a range of emotions, personalities, and reactions; sometimes naive, sometimes skeptical, sometimes rude.

Once a carrier detects a fraudster and routes them to a system like Apate, bots go to work to keep them busy. The bots try different strategies and learn what works to keep fraudsters on the phone line longer. Through successes and failures, the machines fine-tune their patterns.

This way, they can collect information such as the length of calls, the times of day when scammers are likely to call, what information they are after, and the tactics they are using, and extract the information to detect new scams.

Kafal hopes Apate will disrupt the call fraud business model, which is often run by large, multi-billion-dollar criminal organizations. The next step will be to use the information it collects to proactively warn of scams and take action in real time.

“We’re talking about real criminals who are making our lives miserable,” Kafal said. “We’re talking about the risks to real people.”

“Sometimes people lose their life savings, have difficulty living due to debt, and sometimes suffer mental trauma. [by] shame.”

Richard Buckland, a cybercrime professor at the University of New South Wales, said techniques like Apate were different to other types of fraud, some of which were amateurish or amounted to vigilante fraud.

“Usually fraud is problematic,” he said, “but this is sophisticated.”

He says mistakes can happen when individuals go it alone.

“You can go after the wrong person,” he said. Many scams are perpetrated by people in near-slave-like conditions, “and they’re not bad people,” he said.

“[And] “Some of the fraudsters are going even further and trying to enforce the law themselves, either by hacking back or engaging with them. That’s a problem.”

But the Apate model appears to be using AI for good, as a kind of “honeypot” to lure criminals and learn from them, he says.

Buckland warns that false positives happen everywhere, so telcos need a high level of confidence that only fraudsters are directing AI bots, and that criminal organisations could use anti-fraud AI technology to train their own systems.

“The same techniques used to deceive scammers can be used to deceive people,” he says.

Scamwatch is run by the National Anti-Fraud Centre (NASC) under the auspices of the Australian Competition and Consumer Commission (ACCC), and an ACCC spokesman said scammers often impersonate well-known organisations and use fake legitimate phone numbers.

“Criminals create a sense of urgency to encourage their targeted victims to act quickly,” the spokesperson said, “often trying to convince victims to give up personal or bank details or provide remote access to their computers.”

“Criminals may already have detailed information about their targeted victims, such as names and addresses, obtained or purchased illegally through data breaches, phishing or other scams.”

This week Scamwatch had to issue a warning about what appears to be a meth scam.

Scammers claiming to be NASC officials were calling innocent people and saying they were under investigation for allegedly engaging in fraud.

The NASC says people should hang up the phone immediately if they are contacted by a scammer. The spokesperson said the company is aware of “technology initiatives to productize fraud prevention using AI voice personas,” including Apate, and is interested in considering evaluating the platform.

Meanwhile, there is a thriving community of scammers online, and Lenny remains one of their cult heroes.

One memorable recording shows Lenny asking a caller to wait a moment. Ducks start quacking in the background. “Sorry,” Lenny says. “What were you talking about?”

“Are you near the computer?” the caller asks impatiently. “Do you have a computer? Can you come by the computer right now?”

Lenny continues until the conman loses his mind. “Shut up. Shut up. Shut up.”

“Can we wait a little longer?” Lennie asked, as the ducks began quacking again.

Source: www.theguardian.com

Chinese tech company promises to combat online hate speech following knife attack

Chinese internet companies have made a commitment to combat “extreme nationalism” online, specifically targeting anti-Japanese sentiment. This decision comes after a tragic incident in Suzhou, where a Chinese woman lost her life while trying to protect a Japanese mother and child.

The leading companies Tencent and NetEase have stated that they will actively investigate and ban users who promote hatred and incite conflict.

A spokesperson for Tencent, the operator of messaging app WeChat, mentioned that the incident in Jiangsu province has garnered significant public attention, with some internet users fueling tensions between China and Japan, leading to a surge in extreme nationalism.

Following the arrest of an unemployed man for the stabbing incident, which resulted in the death of the Chinese woman who intervened, there has been a mix of reactions online ranging from celebrating heroism to expressing nationalistic sentiments.

Social media platforms like Weibo and Douyin have highlighted the presence of extreme nationalistic and xenophobic content and are actively working to address these issues. This move marks a significant shift as such sentiments have been prevalent on China’s internet with minimal intervention.

In the wake of the Suzhou tragedy, online users have drawn parallels between xenophobic content online and real-world violence, emphasizing the need for regulation to prevent further incidents. Internet companies have reported removing a substantial amount of illegal content and taking action against violating posts.

Despite the efforts by internet companies, some individuals have criticized the crackdown on anti-Japan content, revealing differing perspectives within the online community. Chinese authorities have labeled the knife attack as an isolated event, in contrast to previous incidents involving foreigners.

Further research by Lin Zhihui

Source: www.theguardian.com

The Dangers of Overlooked Fatigue on Your Sleep and Ways to Combat It

You’ve probably experienced this scenario before: after a long day, feeling mentally and physically drained, all you want to do is crawl into bed and sleep.

However, your brain, the most powerful biological supercomputer in the universe, decides to play tricks on you. Instead of allowing you to rest, it keeps you wide awake, with thoughts racing through your mind at lightning speed.

So why does this happen? Why does it prevent us from sleeping when we need it the most? The answer is simple: when you’re too tired, your brain overrides the signals for sleep and keeps you awake.

If you’ve heard of being “over-fatigued” before, it’s often used to describe babies who become agitated and unsettled from being awake too long, leading to sleep disturbances and stress.

Similarly, adults can experience the same issues when unaddressed emotions interfere with the body’s natural sleep processes. The longer you stay fatigued, the more challenging it becomes to fall asleep.

Fortunately, there are ways to break this cycle. In the sections below, we’ll explore what causes excessive fatigue and share three scientifically proven steps to combat it for good.


Excessive fatigue impacts your sleep quality

Being overly tired is a paradoxical situation. When you’re physically and mentally drained, your brain is actually overstimulated and in a state of hyperarousal, making it difficult to transition to sleep.

This hyperarousal state affects essential functions that promote sleep, particularly hindering the buildup of sleep pressure in the brain.

Sleep pressure refers to the buildup of neurochemicals and hormones that increase throughout the day, signaling your body’s need for rest.

“Interestingly, as sleep pressure rises, the brain can become more excitable,” explains Professor Matt Jones, a Neuroscientist at the University of Bristol. “The neurons in the cerebral cortex tend to fire more frequently as wakefulness increases.”

“The primary theory is that sleep helps reset sleep pressure, preventing the brain from becoming overly excited and metaphorically ‘exploding!'”

When you’re vigilant and overwhelmed by racing thoughts, this process of resetting the brain for sleep is disrupted, particularly impacting the locus ceruleus area in the brainstem.

“In times of hyperarousal, the activity in this brain region remains high, impeding the transition to sleep and resisting mechanisms that facilitate falling asleep,” Jones clarifies.

Furthermore, persistent fatigue and sleep deprivation can exacerbate troubling thoughts, making it harder to sleep the following night.

“A study in 2019 found that individuals with insomnia were more likely to ruminate about recent embarrassing events and have disrupted sleep compared to healthy sleepers,” he explains.

“Insomniacs might even become hypersensitive to their heartbeat, showing how an unrested brain struggles to ignore irrelevant stimuli,” Jones adds.

“A well-rested brain can filter out unnecessary information, but insomnia disrupts this process, leading to increased mental strain,” he concludes.

©Getty

Strategies to prevent excessive fatigue

When you’re too tired and key brain regions remain hyperaroused while trying to sleep, essential processes for rest are disrupted.

Dr. Alex Scott, a Psychology lecturer at Keele University, explains that in today’s society, people struggle to regulate their emotions and process daily experiences effectively due to various distractions.

“At the end of the day, we are less inclined to deal positively with our emotions, often exaggerating worries and ruminating in bed,” he shares.

Scott suggests that when fatigued, individuals tend to use unhealthy coping mechanisms, like rumination and blame-shifting.

If rumination proves ineffective for alleviating fatigue, Scott recommends the following three strategies:

1. Avoid counting sheep

Paradoxically, trying too hard to fall asleep can make it even harder. Instead of using traditional methods like counting sheep, Scott encourages individuals to understand that sleep is an automated process that cannot be forced.

“Focus on processing your emotions through exercises like a worry journal,” Scott advises.

2. Maintain a worry diary

Although it may seem tedious, journaling your worries can significantly improve sleep quality for those with sleep issues, according to Scott.

Before bedtime, write down all your concerns in a journal, allowing you to acknowledge them and develop strategies to address them the next day.

“The act of writing down your worries may help you rationalize them and temporarily set them aside, promoting better sleep,” Scott explains.

3. Establish a bedtime routine

Creating a relaxation routine before bed, ideally starting an hour before sleep, can help alleviate mental fatigue and prepare your mind for rest.

“Engage in activities like reading, mindfulness, or journaling during this time to unwind and avoid associating your bed with worries,” Scott suggests.

Learn more about our experts

Professor Matt Jones: A Neuroscientist at the University of Bristol, delving into the science of sleep, memory, and decision-making. His research has been featured in numerous academic journals, such as Frontiers in Neurology, Sleep, and the Neuroscience Journal.

Dr. Alex Scott: As a Psychology lecturer at Keele University, Scott explores the relationship between sleep and mental health issues. His work has been published in esteemed journals like the British Journal of Health Psychology and the British Medical Journal.

Source: www.sciencefocus.com

Taiwanese fact-checkers combat Chinese disinformation and ‘unstoppable’ AI, transitioning from beef noodles to bots

CHarless Yeh’s fight against disinformation in Taiwan started with a bowl of beef noodles. It all began nine years ago when the Taiwanese engineer was dining at a restaurant with his family. His mother-in-law began removing scallions from his dish, claiming they were bad for the liver based on a text message she had received. This prompted Yeh to investigate and reveal the truth.

Confused by the misinformation, Yeh decided to expose the truth on his blog and share it with his family and friends via the Line messaging app. The information quickly spread, leading to requests from strangers who wanted to connect with his personal Line account.

Yeh recognized the demand for fact-checking in Taiwan, leading him to launch the website “MyGoPen” in 2015, which translates to “Don’t be fooled again” in Taiwanese. Within two years, MyGoPen gained 50,000 subscribers and now boasts over 400,000. In 2023, the platform received 1.3 million fact-check requests, debunking various myths and false claims.

Several other fact-checking organizations have also emerged in Taiwan, including the Taiwan Fact-Checking Centre, Cofacts, and DoubleThink Lab. However, as these organizations grow, the threat of disinformation also increases.

The growing and changing threat from China

A study by the Democratic Diversity Project at the University of Gothenburg identified Taiwan as the target of foreign disinformation more than any other democracy, with the most significant threat originating from across the Taiwan Strait, particularly during election seasons.

Doublethink Lab monitors China’s influence in various spheres across 82 countries, ranking Taiwan at the top for China’s impact on society and media and 11th place overall.

Despite the increasing threats, Yeh and his team at MyGoPen continue to combat disinformation using a combination of human fact-checkers and AI. They leverage advanced technologies to verify information and educate the public about evolving disinformation tactics.

Source: www.theguardian.com

Amazon’s Tactics to Combat Union Efforts: Exposing the Lawbreakers

Amazon is facing an anti-government campaign that could lead to increased unionization among its employees, with allegations of unethical behavior surfacing. Workers attempting to organize within the warehouse have reported instances of fear tactics, misinformation, and unlawful retaliation by the tech giant.


Nearly two years ago, workers in Staten Island, New York, made history by forming America’s first warehouse union. As the Amazon union gathered momentum nationwide, the company worked to avoid a similar outcome at other locations.

Nanette Plasencia, a long-time employee at Amazon’s ONT8 fulfillment center in Moreno Valley, California, expressed concerns about the company’s tactics. She mentioned that Amazon is willing to go to great lengths, even if it means breaking the law, to prevent unionization.

Documentation shared with the Guardian revealed how Amazon pushed back against union efforts within ONT8 by disseminating anti-union messages. Employees were subjected to propaganda on TV screens warning them about the negative impact of unions on their paychecks.

These actions have led to allegations of unfair labor practices against Amazon, with the unionization process at the company facing legal challenges from both sides. The situation is currently pending a lawsuit and verdict from the National Labor Relations Board.

Despite facing opposition from the company, Amazon workers in Moreno Valley attempted to hold a union vote in October 2022. However, the election petition was withdrawn following alleged violations of labor laws by Amazon administrators.

The case is set to be heard by an administrative law judge in August, with Amazon denying any wrongdoing at ONT8. They have dismissed the majority of the charges brought against them and are eager to prove their innocence as the legal proceedings unfold.

Source: www.theguardian.com

Global Coalition Formed by the US to Combat Foreign Government Disinformation and Cyber Warfare

The US special envoy addressing the issue announced the formation of a global coalition of democracies to defend against disinformation campaigns by foreign governments.

James Rubin, special envoy for combating non-state propaganda and disinformation at the US Department of State’s Global Engagement Center (GEC), mentioned that the coalition aims to establish a clear understanding of information operations and the rights of other governments. He also highlighted the importance of reaching a consensus on defining common opinion even in moments of disagreement.

The US, UK, and Canada have already signed a formal framework agreement, and there are expectations of more countries joining the coalition. The GEC primarily focuses on countering disinformation campaigns by foreign powers and has been working towards developing a global strategy while uncovering covert disinformation operations, like Russia’s activities in Africa discrediting US health services.

A framework signed between the United States, United Kingdom, and Canada aims to counter foreign manipulation of states by addressing disinformation as a national security threat, requiring a coordinated response from governments and civil society. This emphasizes the need for a collective approach to enhance resilience and response to foreign intelligence threats through information sharing and collaborative data analysis tools.

James Rubin, a seasoned US government official and journalist, serving as a special envoy, acknowledged the complexity of the issue of disinformation and its intellectual challenges. He emphasized the importance of distinguishing between hostile opinion and disinformation to determine the appropriate government interventions.

James Rubin wants to promote more fact-based information. Photo: Tayfun Salcı/ZUMA Press Wire/REX/Shutterstock

He emphasized the need for fact-based information promotion while also finding ways to label information operations originating from foreign governments like China and Russia. He stressed the importance of identifying the sources of covert disinformation without censoring thoughts or opinions.

This challenging issue raises questions about the dynamics between the government and social media companies, particularly in countries like the United States with constitutional guarantees of free speech. In contrast, the European Union has taken more interventionist measures with laws regulating digital services and social media content.

Rubin underscored that it is essential to expose foreign disinformation operations without dictating social media companies’ behavior. He advocated for the enforcement of terms of service by these platforms in combatting disinformation efforts.

Addressing the asymmetry in information space access, Rubin highlighted the challenges posed by closed-off information environments of countries like Russia and China.

Source: www.theguardian.com

Tiny robots may soon navigate human livers to combat cancer

Science fiction has often depicted microscopic robots, but these tiny machines have become a reality with a wide range of real-world applications such as disease prevention and building repair.

A Canadian research team is now focusing on using these small robots to target liver cancer in various fields. They are working on using them in conjunction with MRI equipment to treat diseases (source).

A series of small biocompatible robots, made of magnetizable iron oxide nanoparticles guided by an external magnetic field, could potentially deliver medical care in a highly targeted manner.

Despite the potential of this technology, it faces a major technical challenge. The gravity of these microrobots exceeds the magnetic force, limiting their guidance if the tumor is located higher than the injection site.

To address this challenge, Dr. Jill Soules, a researcher at the CHUM Research Center at the University of Montreal, developed an algorithm that combines gravity and magnetic navigation forces to guide the microrobots into the arterial branches that feed the tumor.


This research has the potential to change the way liver cancer is treated with radiation therapy, which is the most common type of cancer causing 700,000 deaths annually worldwide.

Dr. Soulez emphasized the advantages of the magnetic resonance navigation technique, indicating that the tumor is better visualized on MRI than on X-ray.

In an experiment using pigs to recreate anatomical conditions, the researchers successfully navigated the hepatic artery branches of the animals and arrived at their destination using the microrobots.

Furthermore, using an anatomical atlas of the human liver, the researchers were able to simulate microrobot maneuvers on 19 patients treated with transarterial chemoembolization, finding that in more than 95% of cases, the location of the tumors matched the navigation algorithm to reach the targeted tumor.

Despite these significant advances, clinical application of this technology is still in the distant future, as artificial intelligence models need further training and improvements for real-time navigation of microrobots to the liver.

read more:

Source: www.sciencefocus.com

French Village Votes to Ban Smartphone Scrolling in Public Places in Effort to Combat Intrusion


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A photo of a smartphone with a red line is displayed as a warning on the window of a beauty salon in a French village, after a law was passed to ban scrolling on a mobile phone in public. “Everyone is struggling with too much screen time,” said Rudivin, a cardiovascular nurse with her hair cut into a bob and her cellphone hidden out of sight in her bag. “I voted yes. This might be the solution.”

Seine-Port, a city of fewer than 2,000 people in the Seine-et-Marne region south of Paris, voted yes in a referendum last weekend. Limit the use of smartphones in public places, for adults and children alike, while walking down the street, sitting on park benches with others, and eating in shops, cafes, and restaurants. Forbid parents from scrolling on their smartphones while waiting for their children in front of the car. school gate. People who might check their phone’s maps when lost are encouraged to ask for directions instead.




Seine-Port Mayor Vincent Paul Petit, who pushed for the ban. Photo: Magali Delporte/The Guardian

The village also approved a family charter regarding children’s screen use. Don’t use screens of any kind in the morning, don’t use screens in the bedroom, and don’t use screens before bed or while eating. If a teenager’s parents sign a written agreement not to have a smartphone until the age of 15, City Hall will provide the child with an old-fashioned handset for making calls.

“I’m completely in favor of this,” said Ludivine, 34, who has two children, ages 1 and 4. “Some say this is an attack on freedom, but I don’t think so. It’s about raising awareness about the influence of phones in our lives.

“My 1-year-old doesn’t have a screen. My 4-year-old son doesn’t use a screen during class, and only for fleeting moments while my youngest naps. Many children and adults become addicted to screens. Babies in strollers also have scrolling phone calls. This is to replace that with more human contact. Before I had kids, the TV was always on in the background. Now I never turn it on.”

A total of 277 people, or about 20% of the electoral roll, turned out to vote, with 54% voting in favor of the charter. Mayor Vincent-Paul Petit, a member of the right-wing République party, plans to draw up France’s first municipal ordinance regarding the use of smartphones. The law is not enforceable by police, and there is no national law against smartphones, so police officers could not stop or fine people scrolling on the street, but the mayor said it would stop scrolling. The government explains that the guidance is intended to incite people to do so and restrict the use of telephones. Shop owners have placed stickers on their windows gently reminding people to stop scrolling.




Children walk past a sign prohibiting the use of smartphones outside a village school. Photo: Magali Delporte/The Guardian

At Village Bar, restaurant manager Angelique da Silva said she wouldn’t ask customers to stop scrolling, but she understood the purpose. “This is an interesting idea for kids,” she said. “But the younger generation does not accept this, because if their mobile phone is taken away, they will have nothing left. I did.”

Smartphones and screen time are becoming increasingly political issues in France. President Emmanuel Macron said last month that he would consult scientific experts to “determine the optimal use of screens” for young children, suggesting there could be bans or restrictions.




Angelique da Silva of the restaurant “Terrace” in the Port of Seine. Photo: Magali Delporte/The Guardian

“We want to protect public spaces from smartphone intrusion,” Mayor Paul Petit said. “This does not mean banning all mobile phones, but rather suggesting that people refrain from taking out their smartphones to scroll through social media, play games or watch videos in public places. and that is what we want to maintain for social life.

“This is about the addictive element of smartphones, where we can no longer take our eyes off the screen, whether it’s a game or a social network. We encourage people not to serve people. If you’re talking on the phone, finish your conversation outside and then come in and say hello.”




A sign outside the village school. Photo: Magali Delporte/The Guardian

He added: “Almost every teenager walking down the street has a cell phone in their hand. I understand that the word ‘ban’ may be offending to some people.” . But the important thing is to start the discussion. ”

Noemi, a psychologist waiting for her 8-year-old daughter outside a village school, was in favor of limiting scrolling. She said: “Recently, I brought in books and dolls for her daughter to play with in the waiting room, and everyone congratulated me that her daughter wasn’t on screen.”




Mary Landosy and her son Tao.

Mary Landosy, a school support worker for children with disabilities and the mother of 10-year-old twins, did not vote. “Screens are a part of this generation’s lives, whether we like it or not,” she said. “At the end of the day, if you spend your kids doing fun activities, especially outdoors, they actually don’t want to be on screens. My daughter is a soccer player and she likes being outside. What matters is what alternative activities we can offer.”

Young people in the village complained that there were not enough facilities for teenagers, who had little entertainment other than cellphones. The mayor promised to establish a film club, book exchange and sports facilities.

“There’s not much else to do. If we ban phones, we’ll have to create a serious structure for youth leisure, sports and games,” said Nahuel Dessilon, a history student and teacher intern. (21) says. Her mother Fatiha, a former shop manager, said: “Parents have a responsibility and they can deal with the screen issue themselves.”




Jean-Luc Rodier (right) supports the ban, but his son Gabriel thinks it makes no sense. Photo: Magali Delporte/The Guardian

Her son Gabriel, 20, also a postal worker, objected. “I spend five hours a day on my phone, which I think is reasonable. I also read proper books, but I like looking up things on my phone when I’m around town. You can’t ban knowledge that is readily available.”

Source: www.theguardian.com

The Potential of Marine Fungi: Harnessing Water Mushrooms to Combat Antibiotic Resistance and Pollution

Microscopic marine fungi are abundant, with approximately 2000 species discovered to date.

Dayarathne MC et al. (2020)

Take a walk along the coast almost anywhere in the world and you'll see colorful patches of life growing on rocks, seawalls, and driftwood. These are lichens, a mutualistic partnership between fungi and algae. In the UK, this may include brightly colored orange marine lichens and yellowish coastal sunburst lichens, as well as many other Drabber species.

Lichens are typically thought of as terrestrial organisms, and in fact, the majority grow inland on rocks, tree trunks, leaves, and soil. However, coastal organisms are not creatures that accidentally washed ashore from land; they are marine-adapted species found only on or in close proximity to shores. Until recently, they were considered to be outliers in the almost entirely terrestrial fungal kingdom. No more. “Fungi are present in every marine ecosystem we observe,” says Michael Cunliffe of the University of Plymouth in the UK.

Research on marine fungi is currently rapidly increasing, but their exact role and importance in marine ecosystems remains a mystery. Nevertheless, there are high hopes that it could save us from the two great scourges of the 21st century: antibiotic resistance and plastic pollution.

What are marine fungi?

The existence of marine fungi has been known for many years. The earliest descriptions were published in his mid-19th century to his early 20th century, but these were largely ignored by mainstream mycologists. Most of the species discovered are found on the roots of seaweed that live near the coast.

Source: www.newscientist.com

‘UK Artists Unite to Combat AI Image Generation Software’

Since the advent of Midjourney and other image generators, artists have been observing and wondering whether AI represents a major opportunity or an existential threat. Midjourney names 16,000 artists whose work is said to have been used to train its AI, including Bridget Riley, Damien Hirst, Rachel Whiteread, Tracey Emin, David Hockney, and Anish Kapoor. Now that the list has been revealed, the art world is calling to arms. For engineers.

British artists have contacted U.S. lawyers to discuss joining a class action lawsuit against Midjourney and other AI companies, other artists told a U.S. newspaper. observer They argued that they could bring legal action themselves in the UK.

“What we need to do is come together,” said Tim Flack, president of the Society of Photographers and an internationally acclaimed photographer whose name also appears on the list.

“Releasing this list of names to the public is a great opportunity for artists to come together and take on this issue. Personally, I am in favor of doing so.”

The 24-page list of names constitutes Exhibit J in a class action lawsuit filed by 10 American artists in California against Midjourney, Stability AI, Runway AI, and DeviantArt. “We’re seeing interest from artists around the world, including in the UK,” said Matthew Butterick, one of the artists’ lawyers.

Tech companies have until February 8 to respond to the complaint. Midjourney did not respond to requests for comment.




Bridget Riley and her painting Rajasthan (2012)
Photo: Nils Jorgensen/Rex Shutterstock

Source: www.theguardian.com

Harnessing Nature: Releasing Billions of Engineered Mosquitoes into the Wild to Combat Disease

Dengue fever is currently endemic in 100 countries, putting half of the world’s population at risk. The threat has increased dramatically, with the number of dengue fever cases increasing tenfold between 2000 and 2019, and the number of cases hitting an all-time high in 2023.

Bangladesh, Peru and Burkina Faso have all seen record outbreaks in the past 12 months, while France, Italy and Spain have also reported cases of mosquito-borne dengue fever.

What’s causing this? Scientists say global warming is making space more hospitable to insects, and that climate change is fueling the rise in this mosquito-borne viral disease. As mosquitoes become more common, we expect the time to outbreak of dengue fever to shorten and the transmission season to lengthen.

This is a worrying situation.But that’s what the sponsoring team decided world mosquito program There is a possible solution. They suggest treating mosquitoes with bacteria that can prevent the development of viruses in the body.

read more:

What are the symptoms of dengue fever?

There’s a good reason dengue fever has been labeled “breakbone fever.” 80% of cases are asymptomatic, but when symptoms develop, symptoms include high fever, muscle and joint pain, severe headache, pain behind the eyes, nausea, and vomiting.

Symptoms begin 4 to 10 days after infection and can last from 2 days to up to a week. DHF (severe dengue fever) manifests as severe abdominal pain, persistent vomiting, bleeding gums or nose, blood in the stool or vomit, pale, cold skin, and fatigue. Doctors can only alleviate these symptoms because antiviral drugs are not available.



How does dengue spread?

Dengue fever is spread through the bite of an infected female mosquito. Aedes aegypti, typically found in tropical and subtropical regions. Originating from the forests of West Africa, Aedes aegypti They spread around the world during the African slave trade and have continued to hitchhike as a means of human transportation ever since.

other Aedes Other species can also transmit dengue fever, although to a lesser extent. The highly invasive Asian tiger mosquito is the likely cause of dengue infections in Europe. Unlike malaria mosquitoes, which usually bite at night and can be prevented with insecticide-treated bed nets, dengue mosquitoes bite during the day and are very difficult to control.

Mosquitoes are now highly urbanized creatures, admirably adapted to coexist with humans, their preferred blood source. In cities, stagnant water is key to survival, providing spawning grounds and habitat for aquatic larval and pupal development. Mosquitoes breed in small puddles in garbage, used tires, and man-made containers such as flower pots. Thus, humans have been the main driving force behind the success of the dengue mosquito.

How can we fight the spread of infection?

Dengue prevention requires a multipronged attack on mosquitoes, with a focus on insecticide spraying. However, insecticide resistance is developing in mosquito populations around the world, threatening their effectiveness.

what else? Control strategies also include adaptations to eliminate breeding sites or prevent reproduction. Aedes aegypti Prevent spawning in stagnant water (remove debris that could trap water and install covers on water storage containers).

Bacterial toxins are also applied to bodies of water to kill mosquito larvae. These strategies are labor intensive because it is difficult to identify, treat, and eliminate all breeding sites. Therefore, new methods of mosquito control are desperately needed.

The World Mosquito Program (WMP) has devised a non-chemical and non-GMO-based approach for dengue control. Bacteria called Wolbachia which occurs naturally in many insect species; Aedes aegypti.

WMP was found to be “infected”. Aedes aegypti and Wolbachia Prevented the onset of dengue virus in adult women. From a logistical point of view, this method is self-sustaining. Wolbachia It can spread to wild populations because it infects eggs through mating.

WMP reports a significant decrease in dengue cases. Aedes aegypti carry Wolbachia has been released.given that Aedes aegypti Since Zika and Chikungunya viruses are also transmitted, WMP has developed a potential “three-for-one” method of disease control.

It’s no exaggeration to say that mosquitoes are the most hated insects, but despite their notoriety, only a handful of the 3,500 species of mosquitoes transmit disease. They are also important to the ecosystem.

Mosquitoes are a food source for fish, frogs, reptiles, bats, and birds, and they are also pollinators, as male insects suck nectar from flowers (only females drink blood). The WMP approach is species-specific and targeted only. Aedes aegyptiThis is in contrast to the “blunt force” approach with insecticides, which can affect insects other than the target.

The climate change trajectory we are currently on is leading to rising temperatures and changing rainfall patterns, which will benefit this terrifying little insect and her viral cargo. Therefore, we need as many weapons as possible in our arsenal to combat the growing global dengue threat.

read more:

Source: www.sciencefocus.com

New Strategy Revealed by Scientists to Combat Antibiotic Resistance







Document

The urgent crisis of antibiotic-resistant superbugs is being solved in groundbreaking research by the University of Massachusetts Amherst and Microbiotics. Their research focuses on disrupting the pathogen’s type 3 secretion system, providing a new approach to preventing infectious diseases. This strategy, supported by innovative luciferase-based technology, could pave the way for new drugs, improve our understanding of microbial infections, and lead to major advances in public health. Credit: SciTechDaily.com

The team is developing tests to identify new drugs that neutralize pathogens and provide substantial benefits to public health.

Antibiotic-resistant “superbugs” could overwhelm efforts to eradicate “superbugs” are an imminent public health crisis, with more than 2.8 million antibiotic-resistant infections occurring each year, according to the CDC disease is occurring. Researchers around the world are struggling to address this challenge.

Recently, a collaborative team of researchers led by the University of Massachusetts Amherst and including scientists from biopharmaceutical companies microbiologypublished in a magazine ACS infection They said they have successfully learned how to interfere with a key mechanism used by pathogens to infect host cells, called the type 3 secretion system. Additionally, the researchers report that they have developed a test to identify the next generation of drugs that target this vulnerable cellular machinery and have real benefits for public health.

A typical strategy when treating microbial infections is to attack the pathogen with antibiotics, which work by entering and killing harmful cells. This is not as easy as it sounds. New antibiotics need to be water-soluble so they can easily pass through the bloodstream, and oil-based to cross the cell membranes that are the first line of defense of pathogenic cells. Of course, water and oil don’t mix. It is difficult to design a drug that has enough of both properties to be effective.

The type 3 secretion system relies on two proteins, PopB and PopD (red and blue), which form tunnels in the host cell wall.

That’s not the only problem. Antibiotics can’t cause any harm because pathogenic cells have developed something called an “efflux pump” that can recognize them and safely pump them out of the cell. If an antibiotic cannot overcome the efflux pumps and kills the cell, the pathogen will “remember” what that particular antibiotic is and create additional efflux pumps to deal with it efficiently. Develop. This means that they become resistant to that particular antibiotic.

One way forward is to find new antibiotics or combinations of them to stay one step ahead of superbugs.

“Or you could change your strategy,” says Alejandro Heuch, associate professor of biochemistry and molecular biology at the University of Massachusetts Amherst and lead author of the paper. “I am a chemist and have always been interested in understanding how chemical molecules interact with living organisms. In particular, I understand the communication between pathogens and the host cells they try to invade. We have focused our research on molecules that make this possible. If we don’t try to kill the pathogen, there’s no chance that the pathogen will develop resistance. We’re just jamming that machine. The pathogen is still alive. It’s just ineffective, and the host has no chance of developing resistance. You have time to use your natural defenses to eliminate the pathogen.”

Heuck and his colleagues are particularly interested in a communication system called the type 3 secretion system, which so far is thought to be an evolutionary adaptation unique to pathogenic microorganisms. Understanding host-pathogen interactions.

Like pathogenic cells, host cells have thick and impermeable cell walls. To overcome these, pathogens first developed syringe-like machines that secreted two proteins known as PopD and PopB. Neither PopD nor PopB can break through the cell wall on their own, but together the two proteins can create a “translocon,” the equivalent of a tunnel through the cell membrane. Once the tunnel is established, the pathogenic cell can inject other proteins that serve to infect the host. This entire process is called the type 3 secretion system, and it cannot function without both PopB and PopD. “If you don’t try to kill the pathogen, there’s no chance of it developing resistance,” Huke says. We’re just jamming that machine. The pathogen is still alive. It’s just ineffective, and the host needs time to use its natural defenses to eliminate the pathogen.

Heuck and his colleagues realized that a type of enzyme called luciferase (similar to what makes lightning bugs glow at night) could be used as a tracer. They split the enzyme into two halves. Half of it was integrated into the PopD/PopB protein and the other half was integrated into the host cell.These engineered proteins and hosts can receive a large influx of different compounds. If the host cell suddenly glows, it means that PopD/PopB has broken through the cell wall and recombined her two halves of luciferase, causing it to glow. But what if the cells remain dark? “Then we can see which molecules disrupt the translocon,” Huke says.

Huke was quick to point out that his team’s research not only has obvious applications in the pharmaceutical and public health worlds, but also advances our understanding of exactly how microbes infect healthy cells. “We wanted to study how pathogens work, and suddenly we realized that our discoveries could help solve public health problems,” he said.

Reference: “Cell-based assay to determine translocon assembly of the type 3 secretion system in Pseudomonas aeruginosa using split luciferase” by Hanling Guo, Emily J. Geddes, Timothy J. Opperman and Alejandro P. Heuck , November 18, 2023 ACS infection.DOI: 10.1021/acsinfecdis.3c00482

This research was supported by the Massachusetts Amherst Applied Life Sciences Institute, a Healey Foundation grant, and National Institutes of Health.


Source: scitechdaily.com

Scientists Develop New “Cooling Glass” to Combat Climate Change by Channeling Heat from Buildings into Space

Innovative “cooling glass” developed by researchers at the University of Maryland provides a groundbreaking, non-electrical solution for reducing indoor heat and carbon emissions, and significantly advances sustainable building technology. It shows great progress.

Applying new coatings to exterior surfaces can reduce air conditioning usage and help fight climate change.

Researchers at the University of Maryland have developed an innovative “cooling glass” designed to reduce indoor temperatures without using electricity. This revolutionary material works by harnessing the cold air of outer space.

New technology, microporous glass coating, described in paper published in the journal sciencecan lower the temperature of the material beneath it by 3.5 degrees. Celsius According to a research team led by distinguished professor Liangbing Hu of the university’s School of Materials Science and Engineering, it has the potential to reduce the annual carbon dioxide emissions of mid-rise apartments by 10%.

Cooling mechanism with two functions

This coating works in two ways. For one, it reflects up to 99% of solar radiation, preventing buildings from absorbing heat. Even more interestingly, this universe emits heat in the form of long-wave infrared radiation into the icy universe, whose temperature is typically -270 degrees Celsius, or just a few degrees warmer. absolute temperature.

In a phenomenon known as “radiative cooling,” spaces effectively act as heat sinks for buildings. They use new cooling glass designs and so-called atmospheric transparency windows (the part of the electromagnetic spectrum that passes through the atmosphere without increasing its temperature) to dump large amounts of heat into the infinitely colder sky beyond. Masu. (Although the emissions are much stronger than those from the new glass developed at UMD, the same phenomenon causes the Earth to cool itself, especially on clear nights.)

State-of-the-art durable materials

“This is an innovative technology that simplifies the way we keep buildings cool and energy efficient,” said research assistant Xinpeng Zhao, lead author of the study. “This could help us change the way we live and take better care of our homes and the planet.”

Unlike previous attempts at cooling coatings, the new glass developed by UMD is environmentally stable, withstanding exposure to water, UV light, dirt, and even flame, and withstands temperatures up to 1,000 degrees Celsius. can withstand. Because glass can be applied to a variety of surfaces such as tile, brick, and metal, the technology is highly scalable and can be adopted for a wide range of applications.

The research team could use finely ground glass particles as a binder, bypassing polymers and increasing long-term durability outdoors, Zhao said. We then selected a particle size that maximizes the release of infrared heat while reflecting sunlight.

Climate change solutions and global impacts

The development of cooling glass is in line with global efforts to reduce energy consumption and combat climate change, Hu said, adding that this year’s Independence Day could have been the world’s hottest day in 125,000 years. He pointed out recent reports that it was a day of sex.

“This ‘cooling glass’ is not just a new material, it’s an important part of the solution to climate change,” he said. “By reducing the use of air conditioners, we have taken a big step towards reducing energy usage and reducing our carbon footprint. This is because new technology is helping us build a cooler, greener world. It shows how it can help.”

In addition to Hu and Zhao, Jelena Srebric and Zongfu Yu, professors of mechanical engineering in the University of Wisconsin-Madison’s Department of Electrical and Computer Engineering, are co-authors of the study, each contributing expertise in CO2 reduction and structural design. There is. .

The team is now focused on further testing and practical application of the cooled glass. They are optimistic about its commercialization prospects and have formed a startup company, CeraCool, to scale and commercialize it.

Reference: “Solution-processed radiatively cooled glass” Xinpeng Zhao, Tangyuan Li, Hua Xie, He Liu, Lingzhe Wang, Yurui Qu, Stephanie C. Li, Shufeng Liu, Alexandra H. Brozena, Zongfu Yu, Jelena Srebric, Liangbing Written by Hu, November 9, 2023, science.
DOI: 10.1126/science.adi2224

Source: scitechdaily.com