Tag Archives: Egg

Lab-Fertilized Egg Cells Created from Human Skin DNA

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Laboratories enable modification of human egg cell genetic identity

Science Photo Library / Aramie

Human embryos arise from eggs that utilize the DNA from adult skin cells. This was accomplished with mice. This advancement may offer a pathway for same-sex couples or women facing fertility challenges to have biologically related children.

Researchers have successfully replicated animals through cloning techniques. This involves substituting the nucleus of an egg cell with the nuclei from somatic cells such as skin cells. However, in addition to the legal hurdles surrounding human cloning, many couples desire children that carry genes from both partners, necessitating both sperm and eggs. Shoukhrat Mitalipov of Oregon Health and Science University.

This scenario is complicated by the nature of eggs and sperm being haploid, meaning they contain only one set of chromosomes. The challenge lies in halving the complete set of chromosomes found within cells such as skin cells after selecting an optimal combination of the original genes.

Females develop all of their eggs while still in the womb, where the progenitor cells initially containing 46 chromosomes undergo a complicated process of replication, mixing, and division to reduce to 23 chromosomes.

Mitalipov was intrigued by the possibility of employing natural chemical processes that facilitate chromosomal division in mature human eggs both before and after fertilization to replicate this process in his laboratory.

Having achieved this with mice, Mitalipov and his team are now trialing the method with human subjects. They started by extracting the nuclei from hundreds of eggs donated by healthy women, which were left at a specific development stage linked to chromosomal division. Next, the nuclei of skin cells, known as fibroblasts, from healthy female volunteers were inserted into these eggs. Microscopic images displayed the chromosomes aligned on the spindle and the internal structures necessary for chromosomal separation.

The team then injected sperm from a healthy donor to fertilize some of the eggs, utilizing a method akin to that employed in creating babies using third-party mitochondrial DNA, which can also minimize the risk of specific genetic disorders.

This injection typically causes the eggs to undergo chromosome selection and eliminate duplicate DNA, preparing them for additional reception from the sperm. Nonetheless, in the case of the skin-derived eggs, this process was interrupted, with chromosomes aligning but not separating. Consequently, the researchers attempted again with a new batch of fertilized eggs, applying an electrical pulse that allowed calcium to surge into the egg, emulating natural signals triggered when sperm contact the egg’s outer layer, alongside an incubation period with a drug to activate them from their dormant state pre-fertilization.

Through a series of trials, the researchers successfully halved the chromosome counts in the eggs, discarding any excess. By the conclusion of the experiment, 9% of the fertilized eggs had developed into blastocysts — a dense cluster of cells at about 5-6 days post-fertilization, typically moving into the uterus during IVF treatments. However, the team did not pursue the transfer or sustain the blastocyst beyond six days.

Despite the progress made, the mixtures of genes forming the remaining chromosomes appeared particularly susceptible to defects. “I believe this method is still in its early stages and is not presently suitable for clinical applications,” stated MITINORI SAITOU from Kyoto University in Japan.

Lin from Osaka University noted that while the techniques are “very sophisticated and organized,” they remain “inefficient and potentially hazardous for immediate clinical use.” Nevertheless, Hayashi remarked that the team has achieved a “substantial breakthrough in reducing the human genome.” “This advancement will herald new technologies,” he stated.

Mitalipov acknowledged the validity of the criticisms, emphasizing that his team is actively working to address the existing flaws. “At the end of the day, we’re making progress, but we aren’t there yet,” he remarked.

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Source: www.newscientist.com

Peer Review of the Egg Drop Experiment: A Critical Analysis

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Feedback is your go-to source for the latest news in science and technology from New Scientist. If you have intriguing items to share, please reach out to Feedback@newscientist.com.

Egg vs. Grind

Feedback takes us back to the early days of the 2020 lockdown, when we found ourselves learning alongside our children. This involved engaging in various science-related activities, including setting up experiments for “mini beasts,” which provided a diversion from the complexities of life. Thankfully, we avoided the mishaps of the egg drop experiment.

This hands-on activity challenges kids to create devices that protect eggs from breaking when dropped from a height onto a hard surface. Feedback humorously envisions using a cocktail umbrella as a makeshift parachute to soften the landing. However, there are more serious approaches to this experiment.

A study published in Communication Physics on May 8th highlights the peer-reviewed work of physicist Carmela Padavik Callaghan, who addresses the classic egg drop experiment.

The researchers challenge the common belief that eggs are strongest when dropped vertically from their edge. Traditional wisdom has suggested that the shell’s rigidity in this position reduces breakage. However, after conducting “hundreds of experiments” alongside “static and dynamic simulations,” they found that dropping eggs vertically increases the likelihood of breakage. Instead, they recommend dropping them horizontally for better results.

They note: “By orienting the eggs along the equator, there is a slight benefit, as they can survive a fall from about 0.3 mm above the vertical drop without cracking.”

For readers contemplating an egg toss at a celebrity, this research offers practical guidance for ensuring a successful impact!

Alien Mathematics

What exactly are Unidentified Aerial Phenomena (UAP), previously known as UFOs? According to research by Karim Daghbouche of the German nonprofit Gridsat Stiftung, reverse engineering these phenomena is incredibly complex.

If an unidentified flying object is under scrutiny, reverse engineering its operation could unveil its mechanics. However, Daghbouche highlights the significant challenges, as data collection difficulties and “unknown physics” complicate the process of understanding unconventional propulsion systems.

The mathematical hurdles are formidable, with “NP Complete” signifying a specific type of intricate problem. It may even escalate to Pspace-hard or an entscheidungsproblem, the latter being virtually unsolvable for those unfamiliar with advanced mathematics.

News editor Jacob Aron calls it “incredible,” and Feedback concurs. If potential explanations range from extraterrestrial technology to time travelers and dimensions, narrowing down a single answer becomes problematic.

This might illustrate the notion of “no kidding, Sherlock,” as scientific inquiries often culminate in seemingly obvious conclusions. Yet, if NP is complete, does that really signify a non-solution?

Alternatively, we could ponder a human-centric interpretation of UAPs, attributing them to “honest mistakes.” In that framework, NP would no longer be incomplete, and the situation could become far more manageable.

Feedback was surprised by the concluding remarks in the paper’s summary, which stated that “UAP is deemed UAP because it behaves like modern smartphones in the hands of Neanderthals.”

Feedback believes Neanderthals could likely figure out how to use an iPhone. Thus, more nuanced interpretations of UAPs could emerge.

I’ve Squared

In our mathematical mindset, Brendan Ash notes that we are in a “squared year”: 2025 is 45². The next one won’t come until 2116.

This got Brendan reminiscing about a curious incident from a few years ago during a lengthy road trip. He and his son had fun looking up famous individuals who were born one year and passed the next. Not many fit that description, but Russian neurologist Ivan Pavlov (famous for his dog and bell experiments) was “born in 43 squared” [1849] and died at 44 squared [1936].

A darker thought struck Brendan— “I was also intrigued that Pope Francis was born in 44 squared and quickly predicted his death in 2025.”

For those of us who make such throwaway jokes, there exists a peculiar psychological torment in having such ideas materialize. “My predictions are now fulfilled. I cannot fathom how sinful I should feel,” Brendan reflects.

Have you shared your feedback?

You can send your stories to feedback@newscientist.com. Don’t forget to include your home address. Previous feedback can also be found on our website.

Source: www.newscientist.com

Rice and egg whites transform wood into a translucent window alternative

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A nest box with windows made of transparent wood arranged with heat lamps to test the thermal properties of the material

Bharat Baruah et al. (2025)

The windows and smartphone screens can one day be built from clear wood mixed with egg whites and may be safely composted at the end of life.

Researchers are interested in using wood to make biodegradable alternatives to glass with better insulating properties or replacing plastics with electronic devices. Wood was previously transformed into a transparent material by altering or removing organic polymer lignin from it and injecting epoxy as a replacement, which produces a non-biodegradable product.

now Bharat Baruah Kennesaw State University in Georgia and his colleagues have developed a process of replacing synthetic epoxy with natural egg whites and rice extracts.

“[Previous examples of transparent wood are] It’s very difficult to integrate, it’s difficult to make, and you spend a lot of time, energy and money making them, so we thought of making something that can be easily made naturally,” says Barua.

He was urged to use egg whites in his home building in Assam, India, which dates back to the 1500s, using a cement-like mixture containing sand, sticky rice and egg whites. “It was cement from the time and those buildings are still there,” Barua says. “They are still there, over the fourth century and beyond, and after the fifth century, but that has always been fascinating to me.”

The team ingested a sheet of balsa wood, soaked sodium sulfate, sodium hydroxide, and diluted bleach in a vacuum chamber, removing lignin and hemicellulose, leaving only a paper-like cellulose structure. The voids of the ingredients were then filled with a mixture of rice extract and egg whites and then dried in an oven at 60°C (140°F) to create a translucent plate with a slight brown tint. “It’s not 100% transparent, but it’s translucent,” says Barua. “And it’s biodegradable.”

Barua and his colleagues built a small birdhouse equipped with clear wooden windows as a basic mockup, and found to remain cool at 5-6°C (9-11°F) when exposed to heat lamps than the same birdhouse equipped with glass windows. The study will be presented today at the American Chemical Society’s Spring Conference in San Diego, California.

Barua said further research will investigate technologies to improve the strength and thermal properties of the material, as well as transparency.

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Source: www.newscientist.com

Avian Influenza Detected in Chickens at Texas Factory, America’s Largest Raw Egg Producer Reports

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The largest producer of raw eggs in the nation has announced a temporary halt in production at its Texas factory on Tuesday due to avian influenza. The virus has been found in chickens, and authorities have reported cases at a poultry facility in Michigan as well.

Calmaine Foods, headquartered in Ridgeland, Mississippi, has euthanized about 1.6 million hens and 337,000 hens, or roughly 3.6% of its flock, after avian influenza cases were discovered at its Palmer facility in Texas. The company stated that it has been sanctioned in Texas County.

The plant is situated on the Texas-New Mexico border in the Texas Panhandle, about 85 miles (137 kilometers) southwest of Amarillo and 370 miles (595 kilometers) northwest of Dallas. CalMaine reported that most of its eggs are sold in the Southwest, Southeast, Midwest, and Mid-Atlantic regions of the United States.

The statement from the company mentioned, “We are collaborating closely with federal, state, and local authorities, as well as key industry organizations, to minimize the risk of further outbreaks and manage the response effectively.”

“Calmaine Foods is taking steps to ensure production from other facilities to mitigate any disruptions for customers,” the statement added.

The company clarified that there is no identified risk of avian influenza associated with eggs currently in the market, and no recalls have been issued for eggs.

According to the U.S. Department of Agriculture, properly processed and cooked eggs are safe for consumption. The department confirmed.

A day after the announcement by Cal-Maine, state health officials revealed that one person had been diagnosed with bird flu after potential exposure to an infected cow, but the risk to the public remains low. Federal health officials stated that the human case in Texas is the first documented instance globally of someone contracting this strain of bird flu from a mammal.

In Michigan, avian influenza was detected at a commercial poultry facility in Ionia County by the Michigan State University Veterinary Diagnostic Laboratory, as reported by the Michigan Department of Agriculture and Rural Development.

Ionia County is approximately 100 miles (161 kilometers) northwest of Detroit.

The department confirmed the disease on Monday following laboratory tests, marking the fourth instance since 2022 that the illness was identified at a commercial site in Michigan.

Department spokesperson Jennifer Holton stated on Tuesday that state regulations prohibit the disclosure of poultry types at the facilities. The facility is under quarantine, but no disruptions to the state’s supply chain are anticipated, according to Holton.

Dairy cows in Texas and Kansas reported Federal agriculture officials subsequently confirmed the infection in a Michigan dairy herd that had recently acquired cattle from Texas. An Idaho dairy herd was also added to the list after federal agriculture officials confirmed the presence of avian influenza, according to a USDA press release on Tuesday.

Source: www.nbcnews.com