Numerous methods Kennedy is currently undermining vaccines

At a Senate confirmation hearing to become Health Secretary, Robert F. Kennedy Jr. presented himself as a vaccine advocate. But he, and the agency he leads, have taken widespread, sometimes subtle steps to undermine confidence in the effectiveness and safety of the vaccine.

National Institutes of Health I stopped the funds For researchers who wanted to study vaccine hesitancy and find ways to overcome it. They also cancelled a program aimed at discovering new vaccines to prevent future pandemics.

The Centers for Disease Control and Prevention shelved an advertising campaign for influenza shots. Kennedy inaccurately says that scientists advising the CDC on vaccines have it “Serious, serious conflict of interest” Advertising your product means you can’t trust it.

Ministry of Health and Welfare It cuts billions of dollars to state health agencies, including the funds needed to modernize state programs for childhood immunization. Kennedy said in a televised interview Wednesday that he was unaware of the widely reported development.

The Food and Drug Administration canceled a public meeting with its scientific advisor on the flu vaccine and later kept it behind closed doors. a Top Official Pause Agency Reviews Novavax Covid Vaccine. In a TV interview last week, Kennedy mistakenly stated that a similarly created vaccine would not work against the respiratory virus.

Some scientists say they saw the pattern: efforts to erode support for everyday vaccination, and scientists who have long maintained it as a public health goal.

“It’s a simultaneous process that increases the likelihood of hearing him and reducing the likelihood of hearing other voices,” said Kathleen Hall Jamieson, director of the Annenberg Public Policy Center, of Kennedy.

He “recognizes the voices of other authorities,” she said.

The HHS opposed Mr Kennedy’s opposition to the vaccine.

“Secretary Kennedy is not an anti-vaccine, he’s safe,” department spokesman Andrew Nixon said in a statement. “His focus has always been to ensure that the vaccines were rigorously tested for efficacy and safety.”


Source: www.nytimes.com

Researchers have identified numerous instances of snow leopards dispersing from the Tibetan Plateau.

of snow leopard (panthera uncia) It is a large cat endemic to the Qinghai-Tibetan Plateau and surrounding areas. How this apex predator gradually adapted to its extreme environment remains a mystery due to Tibet’s sparse fossil record. In a new study, scientists examined five records outside Tibet of the snow leopard lineage. Their findings suggest that snow leopards dispersed from the Tibetan Plateau multiple times during the Quaternary period. The anatomy of modern snow leopards shows adaptation to steep slopes and cold/high-altitude environments. The new results suggest that snow leopards gradually strengthened such adaptations, especially since the Middle Pleistocene (800,000 years ago).

We predicted the appropriate distribution and morphospace of extant and fossil snow leopards. Image credit: Jianhao Ye.

The snow leopard is one of the emblematic animals of the Tibetan Plateau and is also distributed in the mountainous regions of Central Asia as well as the Mongolian Plateau.

It has distinctive features that clearly distinguish it from other members of the genus, including long, dense fur, long tail, short face, steep, broad forehead, and large cheek teeth. pantera.

Snow leopards typically live in alpine regions above 3,000 meters above sea level or above the tree line, but can also be found much lower, below 1,000 meters in some areas of Siberia.

The snow leopard’s status on the IUCN Red List is: vulnerablethere are 4,000 individuals. However, as global warming progresses, their distribution is expected to shift northward or to higher altitudes, which will have a major impact.

“Although the unique characteristics of the snow leopard have long been recognized, the correlation between these characteristics and their adaptation to the environment of the Tibetan Plateau, as well as their evolutionary history, remains largely unknown,” said the institute’s researchers. said Dr. Qigao Jianzuo. Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences and Peking University, and colleagues.

“This gap in understanding is primarily due to the rarity of snow leopard fossils on the Tibetan Plateau and surrounding areas.”

In this study, researchers described snow leopard fossils collected from five archaeological sites in Longdan, Gansu Province, China; Arago in France. Zhoukoudian area 3, Beijing, China. Manga Larga, Portugal. Niuyan Cave, Mendougou, Beijing, China.

With the exception of the Uyan Cave fossil, which can be classified as a modern snow leopard, the others show significant differences compared to extant snow leopards.

Scientists concluded that the snow leopards found outside the Qinghai-Tibetan Plateau are not an independent lineage, but rather consist of smaller branches from the main snow leopard branch.

These branches may indicate multiple dispersions of snow leopards from Tibet at different times.

To study the evolution of key morphological characters, the authors conducted a systematic analysis of the functional morphology of modern snow leopards using anatomy, geometric morphometrics, and finite element analysis. carried out.

Their findings show that snow leopards have large eye sockets and highly developed binocular vision, and have advanced stereopsis that allows them to quickly focus on prey even in complex terrain. It suggests that.

“Snow leopards have short snouts and steeply angled jaws, with canine teeth characterized by an approximately circular cross-section,” the researchers said.

“This structure allows them to exert great force and subdue strong prey, but it can also reduce their flexibility.”

“Furthermore, the snow leopard’s well-developed frontal sinus system warms the air it breathes, increasing its respiratory efficiency, making it a well-adapted animal to cold, low-oxygen environments.”

“Additionally, snow leopards have a prominent tympanic sac, which increases their sensitivity to infrasound and allows them to detect prey sounds from greater distances in open areas.”

“Thanks to their large cheek teeth (i.e. premolars and molars), they are able to eat most of the meat of their prey before it freezes in cold environments.”

“Additionally, these teeth improve the snow leopard’s ability to chew on already frozen carcasses.”

“The snow leopard’s scapula and pelvis are relatively small, but the bones in its distal limbs are elongated.”

“This suggests that although their forelimb strength is low, they have high movement flexibility, making them suitable for running and jumping in mountainous areas.”

“Most of these traits represent adaptations to the mountainous environment and their primary prey, Caprinae (sheep and their relatives). Capriidae tend to be slower, but shorter and shorter. It has sturdy limbs and strong horns that provide excellent resistance.

“Only some of the snow leopard’s adaptations are related to high-altitude, low-oxygen conditions.”

The researchers also studied the functional form of the fossil snow leopard by correlating its various morphological features with its functions.

They discovered early snow leopards, including the early Pleistocene. pantera Ah. Pirenaica From Longtan and early Middle Pleistocene Panthera Pirenaica The Frenchman’s lower jaw was already steeply angled, but not yet shortened.

Additionally, their cheek teeth were not enlarged. This suggests an early adaptation to caprine prey. However, no significant specialization for cold environments was evident at this stage.

Fossils from later periods such as the late Middle Pleistocene pantera Ah. anthea Zhoukoudian locality 3 and from the late Pleistocene Panthera Uncia Lusitanawas found to be very similar to modern snow leopards and exhibit comparable adaptations.

However, certain characteristics, such as the development of the ectotympanic cavity and the degree of forehead enlargement, were generally less pronounced in Europeans. Panthera Uncia Lusitana Compare it to the modern snow leopard.

“Bayesian analysis of the rate of morphological evolution indicates that snow leopards began to change rapidly during the Middle Pleistocene,” the authors said.

“This period coincides with the appearance of large ice sheets on the Qinghai-Tibet Plateau.”

“Since the Middle Pleistocene, global climate change has increased, resulting in more severe and prolonged ice ages.”

“These conditions have allowed the snow leopard to expand its range beyond the Qinghai-Tibet Plateau.”

“Notably, the Middle Pleistocene was also the time when many members of the Capriinae began to migrate from the Qinghai-Tibetan Plateau to northern China and Europe, paralleling the migration of snow leopards from the plateau.”

To determine whether fossil snow leopards have similar ecological adaptations to modern snow leopards, researchers analyzed the relationship between the distribution of modern snow leopards and climate data.

They took a random forest approach and trained a model known as species distribution modeling to predict how snow leopards would adapt based on climate conditions.

They then applied climate data from the Last Glacial Maximum to assess the potential maximum distribution of extant snow leopards during that period.

“This result indicates that the potential suitable distribution of snow leopards during the Last Glacial Maximum was significantly larger than it is today,” the scientists said.

“However, regions such as Europe and Beijing were outside of areas considered suitable for distribution.”

“This suggests that fossil snow leopards may have developed different ecological adaptations than modern snow leopards.”

“Therefore, the distribution of fossil snow leopards cannot be fully predicted using modern snow leopard models.”

“Furthermore, it should be noted that these fossil remains are generally located at relatively low altitudes (below 500 meters), but in mountainous environments, and usually contain fossils of the family Caprinae.” It’s important.”

“The only exception is archaeological sites in Portugal, where there are no animal records. This observation suggests that mountainous terrain and associated prey availability may be more important for snow leopards than high altitude, low oxygen conditions. This suggests that there is a possibility that

“Uuyan Cave is the only known place in the world that contains both snow leopard and leopard fossils.”

“We know that today’s snow leopards sometimes share habitat in transition zones near tree lines, so the Niuyang Cave discovery suggests that similar environmental conditions existed there when the fossils were deposited. It suggests possibility.”

“Tracing the evolutionary history and functional-morphological adaptations of the snow leopard, an important target for ecological conservation on the Qinghai-Tibetan Plateau, by integrating paleontology, molecular biology, finite element analysis, and species distribution modeling. I was able to do that.”

“Our findings reveal the evolutionary path of snow leopards and suggest that mountainous terrain may have played a more important role in their survival than climate factors alone.”

These insights are important for ongoing snow leopard conservation efforts and also demonstrate the utility of paleontological conservation.

Dr João Madurell Malapeira said: “Our analysis shows that altitude and snow are definitely not the limiting factors for the distribution of this species, but rather the presence of open and steep spaces. I have come to the conclusion that this may be the case.” Researchers at the University of Florence and the Autonomous University of Barcelona.

“In other words, snow leopards have always adapted to life in the mountains, but they don’t necessarily have to live at high altitude or in places with snow.”

“And this is an encouragement to ensure their survival in climate change conditions like the current one.”

team’s paper Published in a magazine scientific progress.

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Qigao Jiangzuo others. 2025. Insights into the evolution and adaptation to high altitude and cold environments in the snow leopard lineage. scientific progress 11(3);doi: 10.1126/sciadv.adp5243

Source: www.sci.news

Plastic chemicals have been connected to numerous deaths globally

New scientist. Our website and magazine feature science news and long reads by expert journalists covering developments in science, technology, health and the environment.

Plastic food packaging can expose people to chemicals such as bisphenol A (BPA)

Shutterstock/Trong Nguyen

Hundreds of thousands of deaths and millions of heart disease cases worldwide may be linked to chemicals found in common plastic products, and stricter regulations on such toxins are needed. This suggests that there may be potential benefits to public health.

Maureen Cropper researchers from the University of Maryland investigated the effects of oxidation on three chemicals primarily used in plastics: bisphenol A (BPA), di(2-ethylhexyl) phthalate (DEHP), and polybrominated diphenyl ethers (PBDEs). The public health impact of exposure was assessed. BPA and DEHP are used in plastic food packaging, and PBDE is a flame retardant used in some household products such as furniture and electronics.

Based on more than 1,700 studies published to date, the researchers estimated how much people in 38 countries, representing about a third of the world’s population, are exposed to these three chemicals. Three of these countries, the United States, Canada, and South Korea, also have public databases that monitor levels of these chemicals in urine and blood samples, providing more accurate data.

Researchers calculated the health effects caused by these chemicals by combining them with medical records and toxicology reports. Researchers found that in 2015, approximately 5.4 million coronary artery diseases and 346,000 strokes were linked to BPA exposure, and approximately 164,000 deaths among people aged 55 to 64 were caused by DEHP. I discovered that it could be.

Thanks to you rules Since their enactment in the 2000s, the prevalence of these chemicals has decreased in many countries, including the United States, Canada, and Europe. Researchers estimate that approximately 515,000 deaths could have been avoided if exposure to BPA and DEHP in the United States had remained at post-regulation levels since 2003. This highlights the importance for governments and manufacturers to limit the use of hazardous chemicals in plastic products before they reach consumers. says Cropper.

However, it is important to remember that these results are only approximations. “Frankly, I think one of the real limitations is the lack of exposure data on these substances,” Cropper said. This means that estimates may be less accurate for some countries than for others. “It would be a good idea for more countries to actually monitor it.” [exposures to] Examining these and other substances will improve our understanding of their public health burden, she says.

topic:

Source: www.newscientist.com

New review highlights the numerous health benefits of staying well-hydrated

Drinking enough water can help with weight loss and prevent kidney stones as well as migraines, urinary tract infections, and low blood pressure, according to a new systematic review of 18 randomized clinical trials.

A systematic review of 18 randomized clinical trials found that interventions that increased water intake (or decreased intake in some studies) were associated with statistically significant increases in weight loss and reductions in kidney stone events. A single study suggested benefits related to migraine prevention, urinary tract infections, diabetes management, and lower blood pressure, but did not reach statistical significance. Image credit: Günther.

Water is a major component of the human body and is considered an essential nutrient that cannot be produced in sufficient quantities through metabolism.

The National Academy of Medicine recommends a daily fluid intake of approximately 13 8-ounce cups for men and 9 cups for women.

A common public health recommendation is to drink 8 cups of water per day, but the evidence supporting this is not clear.

Determining a single optimal daily water intake is a difficult concept, given the wide variation in body weight, activity levels, and health status at the population level, and the numerous mechanisms that regulate water balance.

Because of the known negative effects of dehydration, behavioral factors and hydration status have been widely studied in relation to health conditions.

Professor Benjamin Breyer of the University of California, San Francisco, and colleagues aimed to summarize the evidence from randomized clinical trials on the effects of increasing daily water intake on health-related outcomes.

“We wanted to take a closer look at such a ubiquitous and simple intervention, as the evidence is not clear and the benefits are not well established,” Professor Breyer said.

“Although the amount of rigorous research turned out to be limited, there were statistically significant benefits in some specific areas.”

“To our knowledge, this is the first study to broadly evaluate the benefits of water intake on clinical outcomes.”

Researchers have found the most evidence supporting drinking water to prevent kidney stones and lose weight.

Drinking 8 cups of water a day significantly reduced the chance of kidney stones recurring.

Some studies have found that drinking about 6 glasses of water a day can help adults lose weight.

However, a study of adolescents found that drinking just over 8 cups of water a day had no effect.

Still, encouraging people to drink water before meals is a simple and inexpensive intervention that could have significant benefits, given the rise in obesity.

Other studies have shown that water can help prevent migraines, manage diabetes and low blood pressure, and prevent urinary tract infections.

Adults with recurring headaches felt better after drinking more water for three months.

Drinking about 4 more cups of water a day helped diabetics with elevated blood sugar levels.

Drinking an additional 6 cups of water per day also helped women with recurrent urinary tract infections. The number of infected people has decreased and the time between infections has increased.

And drinking more water helped young people with low blood pressure.

“Dehydration has been shown to be particularly harmful for people with a history of kidney stones or urinary tract infections,” says Professor Breyer.

“On the other hand, people who sometimes suffer from frequent urination may benefit from drinking less alcohol. There is no one-size-fits-all approach when it comes to water consumption.”

of the team paper Published in a magazine JAMA network open.

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Nizar Hakam others. 2024. Results of randomized clinical trials testing changes in daily fluid intake: a systematic review. JAMA Net Open 7 (11): e2447621;doi: 10.1001/jamanetworkopen.2024.47621

Source: www.sci.news

Lawyer Exposes: US Police Allegedly Prevented Access to Numerous Online Child Sexual Abuse Reports

The Guardian has revealed that social media companies relying on artificial intelligence software to manage their platforms are producing unworkable reports on child sexual abuse cases, leaving U.S. police unable to uncover potential leads, which is delaying the investigation into suspected looters.

By law, U.S.-based social media companies are required to report child sexual abuse content detected on their platforms to the National Center for Missing and Exploited Children (NCMEC), which serves as a national clearinghouse for child abuse information and forwards information to relevant law enforcement agencies in the United States and around the world. The company said it received more than 32 million reports of suspected child sexual exploitation and approximately 88 million images, videos, and other files from businesses and the general public in 2022.

Meta is the largest reporter of this information, with over 27 million (84%) generated by Facebook, Instagram, and WhatsApp platforms in 2022. NCMEC is partially funded by the Department of Justice and also receives private sources of corporate donations.

Social media companies, including Meta, use AI to detect and report suspicious content on their sites and employ human moderators to send some flagged content to law enforcement. However, U.S. law enforcement agencies can only disclose AI-generated child sexual abuse material (CSAM) by serving a search warrant on a company that has filed a report, which can add days or even weeks to the investigation process.

“If a company reports a file to NCMEC and does not indicate that it viewed the file before reporting, we will not be able to open the file,” said Staka Shehan, vice president of analytical services at NCMEC.

To protect your privacy under the Fourth Amendment, neither law enforcement officials nor the federally funded NCMEC will issue a search warrant unless the contents of the report are clear and first reviewed by a social media company representative.

NCMEC staff and law enforcement agencies cannot legally see the content of AI-generated content that is not seen by humans, which can stall investigations into suspected predators for several weeks, resulting in the loss of evidence that may be possible to connect.

“Any delay [in viewing the evidence] “The longer criminals go undetected, the more detrimental it is to ensuring community safety,” said an assistant U.S. attorney in California, who spoke on condition of anonymity. “They are dangerous to all children.”

In December, the New Mexico Attorney General’s Office filed a lawsuit against Meta, alleging that its social network has become a marketplace for child predators and that Meta has repeatedly failed to report illegal activity on its platform. woke up. In response, Meta said its priority was to combat child sexual abuse content.

The state attorney general laid the blame for the fight to send actionable information at the feet of Meta. “Reports showing the inefficiency of the company’s AI-generated cyber information systems prove what we said in the complaint,” Raul Torrez said in a statement to the Guardian.

To ensure the safety of children, keep parents informed, and enable law enforcement to effectively investigate and prosecute online sex crimes against children, the company is reforming, staffing levels, and policies. , it’s long past time to implement algorithmic changes,” Torrez added.

Despite legal limitations on moderation AI, social media companies are likely to increase its use in the near future. In 2023, OpenAI, developer of ChatGPT, announced they claimed that large-scale language models can do the job of human content moderators and have roughly the same accuracy.

However, child safety experts say that the AI software used by social media companies to moderate content already knows the digital fingerprints of images, known as hashes, and that the AI software used by social media companies to moderate content cannot be used to detect known cases of child sexual abuse. It claims to be effective only when identifying images of Lawyers interviewed said AI would be ineffective when newly created images or when known images or videos are altered.

“There is always concern about cases involving newly identified victims, and because they are new, the materials do not have a hash value,” said the director of the Zero Abuse Project, a nonprofit organization focused on combating child abuse.
said senior lawyer Kristina Korobov. . “If humans were doing the work, there would be more discoveries of newly discovered victims.”

In the US, please call or text us. child help Abuse Hotline 800-422-4453 or visit
their website If you need more resources, please report child abuse or DM us for help. For adult survivors of child abuse, support is available at the following link:
ascasupport.org. In the UK,
NSPCC Support for children is available on 0800 1111 and adults who are concerned about a child can call 0808 800 5000. National Association of Child Abuse (
napak) offers support to adult survivors on 0808 801 0331. In Australia, children, young people, parents and teachers can contact the Kids Helpline on 1800 55 1800.
brave hearts Adult survivors can contact 1800 272 831
blue knot foundation 1300 657 380. Additional sources of help can be found at:
Child Helpline International

Source: www.theguardian.com

Excessive Cannabis Use Associated with Numerous Health Problems According to New Study

A Yale University study that analyzed the genomes of more than 1 million people revealed genetic factors associated with cannabis use disorder and potential links to psychiatric problems, substance abuse, and lung cancer risk. The importance of understanding the health effects is emphasized.Credit: Illustration by Michael S. Helfenbein

A comprehensive study conducted by researchers at Yale University and involving the analysis of the genomes of more than 1 million people has provided new insights into the biology of cannabis use disorder. The study also investigated links to various mental illnesses, the propensity to abuse other substances such as tobacco, and the potential increased risk of lung cancer associated with cannabis use.

For this study, researchers analyzed genome-wide genetic variation in individuals from multiple ancestry groups enrolled in the U.S. Department of Veterans Affairs’ Million Veterans Program, one of the world’s largest genetic databases. set and incorporated additional information from several other genomic databases. . They were able to identify dozens of genetic variants associated with cannabis use disorder, as well as a variety of behavioral and health problems associated with cannabis use disorder.

Understand the risks of marijuana use

The study was led by Daniel Levey, assistant professor of psychiatry, and Joel Gelernter, Foundation Professor of Psychiatry and Professor of Genetics and Neuroscience, and was published Nov. 20 in the journal Psychiatry. natural genetics.

“Understanding the biology of cannabis use disorder can help us better understand associated disorders and inform the public about the risks associated with cannabis use,” said Levy, lead author of the study. .

According to the U.S. Centers for Disease Control and Prevention, marijuana is the most commonly used federally illegal drug in the United States, with more than 48 million people (18% of Americans) using marijuana at least once in 2019. There is. Previous research has shown that approximately one-third of marijuana users develop cannabis use disorder, a pattern of problematic cannabis use that results in clinically significant impairment and distress. Defined.

Genetic factors and health risks associated with cannabis use

The new findings provide insight into the genetic factors underlying this phenomenon and other health risks that may be associated.

For example, researchers found that variants in genes encoding three different types of receptors on neurons are associated with an increased risk of developing cannabis use disorder.

They found that these mutations associated with cannabis use disorder were also associated with the development of lung cancer. However, the authors added that more research is needed to distinguish the effects of marijuana use from the effects of tobacco use and other environmental factors on cancer diagnosis.

“This is the largest genome-wide study of cannabis use disorder ever conducted, and as more states legalize or decriminalize marijuana use, studies like this one will “This could help us understand the public health risks associated with this increase,” said Gelernter.

Reference: “Multi-ancestral genome-wide association study of cannabis use disorder provides insight into disease biology and public health implications” Daniel F. Levey, Marco Galimberti, Joseph D. Dieck, Frank R. Wendt, Arjun Bhattacharya, Dora Koller, Kelly M. Harrington, Rachel Quaden, Emma C. Johnson, Priya Gupta, Mahantesh Birader, Max Lamb, Megan Cook, Veera M. Rajagopal, Stephanie LL Empke, Han Zhou, Yaira Z. Nunez, Henry R. Kranzler, Howard J. Edenberg, Alpana Agrawal, Jordan W. Smaller, Todd Lentz, David M. Hougaard, Anders D. Borglum, Ditte Demotis, Veterans Affairs Million – Veterans Program, J. Michael Gaziano, Michael J. Gandal, Renato Polimanti, Murray B. Stein, Joel Gelernter, November 20, 2023, natural genetics.
DOI: 10.1038/s41588-023-01563-z

Source: scitechdaily.com