Daily Pills May Offer a Substitute for Weight Loss Injections

Pills may provide a more convenient method for taking weight-loss medications

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An oral pill could soon serve as an alternative to Wegovy and Ozempic injections after research demonstrated that it significantly reduces weight and enhances blood sugar levels in individuals with obesity and type 2 diabetes.

Created by the pharmaceutical giant Eli Lilly, Orforglipron mimics the action of semaglutide, the key ingredient found in Wigovy and Ozempic, by imitating a hormone known as GLP-1.

In a previous trial, researchers discovered that individuals who were obese but did not have type 2 diabetes could lose an average of approximately 11 percent of their body weight over 72 weeks while using Orforglipron. Although this is less than the 15% typically observed with similar treatments, many find the convenience of taking a pill more appealing. With semaglutide injections, the preference for oral medication becomes clear, as noted by Deborah Horn from the University of Texas.

To assess its effectiveness for those with obesity and type 2 diabetes, Horn and her colleagues enlisted over 1,600 individuals from ten countries, including India, Australia, China, Germany, Brazil, and the United States.

Approximately 900 participants were assigned to receive varying daily doses of orforglipron—low, medium, or high—while the remainder received placebo pills alongside lifestyle guidance.

After 72 weeks, individuals in the high-dose group lost nearly 10 percent on average, with 67 percent of that group achieving over 5 percent weight loss. The middle and low-dose groups recorded around 7 percent and 5 percent reductions, respectively, while the placebo group had less than a 3 percent decrease.

This study reaffirms that Orforglipron results in less weight loss compared to injectable GLP-1 medications; however, it may still enhance health and quality of life. Stefan Trapp from University College London, who did not participate in the study, remarked, “Even a modest 5% weight loss generally leads to clear benefits, such as increased exercise capacity, lifestyle changes, and reduced risk of other illnesses.”

Moreover, participants receiving high doses experienced an average drop of nearly 2 percent in blood sugar levels, with approximately 75 percent reaching levels typically aimed for diabetics, Horn shared. Conversely, those on lower doses saw a mere 0.1% reduction, while the placebo group exhibited no significant change.

Roughly 10% of the individuals taking high and medium doses had to discontinue use due to side effects like nausea, vomiting, and diarrhea—nearly double the occurrence seen in the low and placebo groups. Nonetheless, most participants deemed the side effects manageable, according to Horn. “The side effects were standard for other GLP-1 injectable medications,” she explained.

Horn mentioned that Eli Lilly anticipates the FDA will approve the drug for obesity and type 2 diabetes by early next year. As a physician, she hopes for approval of all three doses to provide patients with options to optimize their health while minimizing side effects.

Orforglipron does not necessitate refrigeration or syringes, which may lower manufacturing, storage, and distribution costs compared to injectable GLP-1 drugs. This, along with the elimination of injection-related discomfort, could enhance access to GLP-1 weight-loss drugs, which are currently costly and hard to obtain in many low- and middle-income nations, Trapp noted.

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Source: www.newscientist.com

The Great Multivitamin Myth: How Pills Can Harm Your Immune System

The immune system is intricate, consisting of a vast network of cells, proteins, and organs that serve as the body’s primary defense against infections. Given its vital role, it’s essential to maintain its health.

So, how can you achieve that? Similar to other crucial bodily functions, numerous supplements and products claim to enhance your immune system’s performance. However, the reality is that your body may not require these so-called enhancements. In fact, it often functions best when left to its natural processes.

Misconceptions About Immune Boosting

The idea of vitamins that “boost” immunity can be quite misleading. In theory, the immune system is self-sufficient and operates optimally if you maintain a healthy lifestyle.

Moreover, “boosting” the immune system is a somewhat ambiguous notion. Simply increasing the quantity of immune cells or similar components in your body may not be beneficial and could potentially be harmful.

Consider your immune system as a finely tuned machine, operating at peak efficiency as long as it receives proper maintenance. Attempts to push this machine into overdrive may lead to overheating or malfunction.

The same principle applies to the immune system; an overstimulated immune response can inadvertently attack healthy cells, resulting in autoimmune disorders.

“The immune system can typically maintain its own balance. As long as you adhere to a relatively healthy lifestyle, no additional enhancement is necessary,” stated Dr. Bobby Cherayil, author of The Logic of Immunity, in an episode of BBC Science Focus.

“This includes a nutritious diet, sufficient sleep, regular physical activity, and avoiding harmful practices such as smoking or excessive alcohol consumption.”

Though a decline in lifestyle can affect our immune system, this deterioration is gradual, often requiring severe circumstances for visible infection to occur.

“A diet lacking essential nutrients or severe vitamin deficiencies can negatively impact your immune system, but such deficiencies are generally quite extreme.”

Risks Associated with Vitamin Supplements

If you maintain a healthy lifestyle—eating well, sleeping adequately, and exercising regularly—what risk is there in taking supplements aimed at enhancing your immune system?

Often, the risks are minimal, with the primary concern being the lack of effectiveness. The body can only absorb a certain amount of vitamins, and excess amounts typically pass through the body and are expelled in urine.

This applies mainly to water-soluble vitamins; however, vitamins A, D, E, and K do not leave the system so easily, and an excess can lead to toxicity. For instance, too much vitamin D can cause nausea, weakness, and may ultimately lead to bone and kidney pain if left untreated.

Many immune-boosting supplements are categorized as “multivitamins,” which encompass various vitamins and minerals in a single tablet or capsule.

A significant study associated multivitamins with a high rate of placebo effects. Research indicates no significant health statistics difference from a control group.

Clinical trials revealed no notable variation in mental or physical health outcomes between those taking multivitamins and those who were not. However, individuals consuming multivitamins often believe these products contribute positively to their health.

The danger is that individuals might assume multivitamins can substitute for other health-boosting practices, leading to neglect in other health areas such as maintaining a balanced diet.

Long-term effects of excessive vitamin intake remain less understood, with some studies suggesting a connection between multivitamin use and increased risk of cancer, heart failure, or cardiovascular issues.

Research indicates risk may increase with age. A study from the University of Minnesota found that among over 38,000 women aged 62 and older, those taking supplements had a 2.4% higher mortality risk.

This area of research continues to evolve, and not all studies reach such dire conclusions. For instance, another study found no significant correlation between multivitamin use and overall mortality rates.

Vitamins Have Their Place…for Some

For many, a healthy lifestyle is all that’s needed to keep the immune system in optimal condition. However, there are individuals with significant vitamin deficiencies that require attention.

Globally, over 2 billion people lack essential vitamins, and certain demographic groups may require additional support.

Vitamin supplements can be beneficial, particularly for older adults who struggle with chewing or swallowing. This is also true for pregnant individuals or those with digestive issues (always consult a healthcare professional).

Ultimately, the immune system remains a highly advanced, self-regulating entity. For the average person, it functions effectively on its own. Immune-boosting supplements may not pose significant risks, but they often result in “expensive urine.”


About Our Expert, Bobby Cherayil

Cherayil is an associate professor of Pediatrics at Harvard University and author of The Logic of Immunity. His research focuses on the immune system and its response to infection and inflammation.

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Source: www.sciencefocus.com

How Tinsel Science is Pushing to Restrict Access to Abortion Pills

Secretary of Health and Human Services Robert F. Kennedy Jr. has tasked the Food and Drug Administration with conducting a safety assessment of Mifepristone, the primary medication used in most abortions in the U.S. This week, Kennedy indicated that the review was prompted by a “surprising” report on significant adverse events that was released last month.

“At the very least, it clearly indicates that we need to modify the labeling,” he stated during the Senate budget hearing on Wednesday, addressing Senator Josh Hawley (R-Mo). “We requested FDA Director Marty McCurry to carry out a comprehensive review and provide a report.”

The report suggests that neither peer-reviewed studies nor medical journals have identified a higher rate of serious complications from Mifepristone than that reported by the FDA. It calls for “further investigation into the harm Mifepristone may cause to women” and urges a “reconsideration of its approval entirely.”

Published online in April by the Center for Ethics and Public Policy, a conservative think tank that endorses Jewish and Christian values, the center is associated with the Advisory Committee for Project 2025, which pushes right-wing policy initiatives allegedly influencing many recent actions by President Donald Trump.

A few days before the report’s release, FDA Commissioner Marty McCurry mentioned that he had no intention of taking action against Mifepristone unless new data indicated safety concerns.

Hawley has consistently voted to restrict abortion access, and called on McCurry last month to restore certain restrictions that have made obtaining Mifepristone challenging, including requiring doctors to handle the process directly.

Conversely, data shows that fewer than 0.5% of women taking Mifepristone experience serious side effects, while the report claims the actual figure is about 11%.

Researchers studying reproductive health have criticized the report as junk science, exaggerating the medication’s risks.

Dr. Ushima Upadyyay, a public health scientist from the University of California, San Francisco, expressed on Thursday, “We should be cautious about public health officials demanding a review of science.”

“A rigorous study, which involved my own consultation with a clinician, ensured that the medication is safe for use at home,” she added.

The report claims its analysis is based on 865,727 insurance claims for women prescribed abortion medications, yet it does not disclose the database used, failing to adhere to standard scientific research protocols. Multiple external researchers have noted that the definition of a “serious adverse event” is broad enough to capture minor side effects like daily bleeding. However, the report’s authors assert that they excluded mild or moderate events.

Regardless, complications after medication abortions were categorized as “serious” in contradiction to medical consensus. The Mifepristone label already indicates that the treatment fails in roughly 2.6% of cases, with the physician community suggesting the failure rate may reach up to 5%. Additionally, the report classified ectopic pregnancies as serious incidents, even in the context of Mifepristone use.

Alina Salganicoff, the director of the Women’s Health Policy Program at KFF—a health policy research and news organization—asserted that the report “does not meet generally accepted research standards,” noting that using insurance claims to evaluate abortion outcomes is ineffective as “many abortions, especially early ones, are not covered by insurance.”

Rachel Jones, a leading research scientist at the Guttmacher Institute, an organization advocating for abortion access, remarked that the report seems to stem from ideology rather than science.

“The FDA typically relies on clinical trials and studies, but this isn’t the case here. It should not influence current policies,” she stated.

The authors of the report responded to these criticisms in a post on the Center’s website, claiming the peer review system is biased against anti-abortion groups, leaving “no opportunity to publish peer-reviewed analyses that provide critical views on abortion medications.”

“As the largest ever study on abortion drugs reveals they are neither safe nor effective, the abortion industry has opted to misrepresent our findings to protect their financial interests, jeopardizing women’s health,” said the report.

Dr. Christina Francis, CEO of the American Pro-Life Physicians Association, indicated that the report sends a message for the FDA to conduct a thorough reassessment of Mifepristone’s safety.

“We have long urged the FDA to conduct a more detailed review of the real-world complication rates,” she explained. “In my view, this report is timely and much needed.”

HHS, which handles media inquiries for the FDA, did not provide comments upon request.

Reproductive health researchers argue that disseminating flawed research represents one of the many strategies employed by anti-abortion groups to restrict access to Mifepristone, alongside litigation and lobbying federal officials.

“Organizations wishing to ban abortions often produce these types of studies,” said Jones.

Misleading research has previously contributed to legal challenges against Mifepristone access, which were ultimately withdrawn by the Supreme Court. In a 2023 decision temporarily revoking Mifepristone’s approval, U.S. District Judge Matthew Kakusmalik cited a study from an anti-abortion group that was later retracted by a medical publisher.

Attorneys General from Idaho, Kansas, and Missouri sought to revive a lawsuit in October against Mifepristone in the same Texas federal court. However, earlier this month, the Trump administration requested the judge dismiss the case.

Julia Kaye, a senior staff attorney with the ACLU Reproductive Freedom Project, indicated at a press conference that this might complicate the administration’s legal arguments in other ongoing cases. Other legal experts view this as a strategy to sidestep taking a definitive stance on abortion.

During his confirmation hearing, Kennedy pledged to align with Trump on abortion issues, proposing on Wednesday that Trump would ultimately determine how Mifepristone is managed in the U.S.

“We believe that policy shifts will ultimately pass through President Trump,” he stated.

Source: www.nbcnews.com

Norovirus Vaccine Pills Guard Against Winter Vomiting Bugs

Illustration of Norovirus Particles

J Marshall/Tribaleye Images/Alamy

In a few years, vaccine pills for norovirus that lower infection risk may become available, following promising trials where participants were deliberately exposed to the virus.

This highly contagious virus affects the stomach and intestines, resulting in vomiting and diarrhea, usually subsiding within a few days. “The economic impact is significant, with billions lost globally annually due to work absences and hospital visits,” stated Sarah Cady from Cornell University in Ithaca, New York.

Shawn Tucker from the biotech company Vaxart in San Francisco and his team have developed an oral vaccine that appears to increase IgA antibody levels, which can block noroviruses from infecting cells.

The current study involves 141 individuals aged 18 to 49, with half receiving the vaccine pill and the others a placebo. One month later, all participants ingested a high dose of the Gi.1 strain of norovirus in liquid form during quarantine. “Typically, to infect someone in a real-world scenario, you need to introduce 10 to 100 virus particles; we used 1 million particles,” Tucker explained, ensuring a sufficient infection rate.

Results showed that 82% of the placebo group became infected, whereas only 57% of those vaccinated were infected.

“Most people seem interested in receiving the vaccine if it can reduce risks by [25 percentage points] and lessen debilitating symptoms,” said Cady, who was not part of the research.

Additionally, vaccinated participants expelled considerably less stool and viral particles compared to the placebo group. This indicates the vaccine may help slow the virus’s spread, but further testing is needed, according to Cady.

Another analysis suggested the vaccine possibly works by boosting IgA antibodies in saliva, intestines, blood, and nasal passages.

However, the duration of this protection remains uncertain. More research is required to explore its effects on young children and the elderly, who are particularly vulnerable to hospitalization, said Cady.

Most human-infecting noroviruses belong to two clusters known as GI and GII. Based on preliminary findings, Tucker believes the GI.1 vaccine will likely offer protection against other closely related GI variants. The team is also working on vaccines that could shield against both GI and GII viruses.

If everything progresses positively, Tucker anticipates the GI.1 vaccine could be released in two to three years.

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Source: www.newscientist.com

Catherine McCormick: Unleashing the Power of Birth Control Pills

This article is part of It’s overlookedno obituaries were reported in the times about the astonishing people who died in 1851.

Katherine Dexter McCormick was born into a life of wealth that has deteriorated through marriage, but may have simply enjoyed many of the benefits that flowed in her way. Instead, she placed her considerable fortune, in line with her considerable intentionality, to make the woman’s life better.

Activist, philanthropist and benefactor McCormick strategically used her wealth. Most notably, he undertook basic research that led to the development of contraceptives in the late 1950s.

Previously, contraception in the US was very limited, with diaphragm and condoms being banned. The advent of pills made it easier for women to plan when and whether they have children, and promoted the explosive sexual revolution of the 1960s. Today, the pill is despite some side effects Most widely used A reversible form of birth control in the United States.

McCormick’s interest in birth control began in the 1910s when she learned of Margaret Sanger, a feminist leader who was imprisoned for opening the country’s first birth control clinic. She shared Sanger’s passionate belief that women should be able to diagram their biological fate.

The two met in 1917 and soon hatched an elaborate scheme for smuggling diaphragms into the United States.

Diaphragm was prohibited under the Comstock Act of 1873, resulting in a federal crime of mailing or delivering “indecent, indecent or crude” material, including pornography, birth control, and items used for abortion. (I have received laws that still prohibit mailing items related to abortions New attention (Because the federal rights to abortion were overturned in 2022)

Fluent in French and German, McCormick traveled to Europe, where the diaphragm was commonly used. She studied biology at the Massachusetts Institute of Technology and was able to possibly possibly in a meeting with the diaphragm maker. “She bought hundreds of devices and hired a local tailor to sew it on her dresses, evening dresses and coats.” Articles from 2011 MIT Technology Review. “Then she wrapped her clothes around and stuffed them neatly into the trunk for shipping.”

She and her steamer trunks passed through customs. If authorities had stopped her, they would have said, “Only the slightly fluffy dresses that own the boss’s socialites would ooze such self-importance, grandly restraining Porter and doubting nothing.”

From 1922 to 1925, McCormick smuggled over 1,000 diaphragms into Sanger’s clinic.

After her husband passed away in 1947, she took over a significant amount of money, and she asked Sanger for advice on how to put it to use birth control advances. In 1953, Sanger introduced Gregory Goodwin Pinkus and Min Chew Chan, a researcher in Worcester experimental biology in Massachusetts.

She was excited by their work and provided what she needed to provide almost all of the funding (about $23 million today). She even moved to Worcester to monitor and encourage their research. Pincus’ wife Elizabeth explained that McCormick was a warrior.

Food and Drug Administration Pill has been approved For birth control in 1960.

Katherine Moore Dexter was born on August 27, 1875 in Dexter, west of Detroit, to a family of wealthy social activists. The town is named after his grandfather, Samuel W. Dexter. Samuel W. Dexter founded it in 1824, maintaining an underground railway stop in the home where Catherine was born. Her great grandfather, Samuel Dexter, was the Secretary of Treasury under President John Adams.

Catherine and her brother, Samuel T. Dexter, grew up in Chicago. Their mother, Josephine (Moore) Dexter, was a Boston Brahmin who supported women’s rights. Their father, Wirt Dexter, was a powerful lawyer who served as president of the Chicago Bar Association and director of the Chicago, Burlington and Quincy Railroads. He also later led the relief committee. Amazing Chicago Fire In 1871 he was a major real estate developer.

He passed away when Catherine was 14 years old. A few years later, her brother died of meningitis while attending Harvard Law School. Those early deaths directed her into a medical career.

She attended MIT and majored in biology. A rare achievement for women of that era. She arrives with her own heart and successfully completes the rule that female students must always wear hats, claiming that they always pose a fire risk at the Institute of Science. She graduated in 1904 and was planning to attend medical school.

But by then she had begun dating the dashing Stanley Robert McCormick, whom she knew in Chicago. She knew in Chicago. As a young lawyer, he helped negotiate the merger that became his family. Main owner of International HarvesterBy 1909 it was America’s fourth largest industrial company and was measured by assets.

McCormick persuades Katherine to marry him instead of going to medical school. They married at their Swiss mother Chateau and settled in Brookline, Massachusetts.

However, even before they got married, he showed signs of mental instability, so he began to experience violent and delusional delusions. He was later admitted to hospital with what was later determined to be schizophrenia and remained under psychiatric care – almost Riven Rock, Until his death, McCormick Family Estate in Montecito, California. She never divorced him and never remarried. They had no children.

Katherine McCormick spent decades in personal, medical and legal disputes with her husband’s siblings. They fought about his treatment, his protection, and ultimately his property, Prologue Magazine’s 2007 articlePublications of the National Archives. She is his sole beneficiary, inheriting about $40 million ($563 million in today’s dollars). She combined with the $10 million inherited from her mother (more than $222 million today) made her one of America’s wealthiest women.

As her husband’s illness consumed her personal life, McCormick threw herself into social causes. She contributed financially to the suffrage movement, gave speeches, demonstrated leadership and demonstrated leadership to become treasurer and vice president. National Women’s Suffrage Association. After women gained the right to vote in 1920, the association evolved into a federation of women’s voters. McCormick has become vice president.

In 1927 she founded the Neuroendocrine Research Foundation at Harvard Medical School. She provided funding for 20 years, gaining expertise in endocrinology, and later conveyed her interest in the development of oral contraceptives.

After the FDA approved the pill, McCormick turned his attention to funding the first on-campus residence for women at MIT when he studied there. The women did not have a home. “If we can properly accommodate them, the best science education in our country will be open forever,” she said.

Named after her husband, McCormick Hall opened in 1963 on the Institute’s Cambridge campus. At the time, women accounted for about 3% of the school’s undergraduate students. Today they make up about 50%.

By the time she died of a stroke at her Boston home on December 28, 1967, McCormick was playing a major role in expanding opportunities for women in the 20th century. She was 92 years old.

Apart from the short Boston Globe article, she barely noticed her death. The later obituaries of birth control researchers she supported did not mention her role in their achievements.

At her will, she left $5 million in the planned Parent-Child Relations Federation (more than $46 million today) and $1 million in the Pincus Institute (more than $9 million today). Previously, she had donated Swiss successive property to the US government for use by diplomatic missions in Geneva. She left most of the rest of her property

Source: www.nytimes.com

Promising Norovirus Vaccine Pills Show Effectiveness Against Winter Vomiting Bug

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Impressions of Norovirus artists

Science Photo Library/Aramie

Early trials of the norovirus vaccine pill are committed to protecting against the infamous “winter vomiting” bug, and researchers say it could be used in a few years.

The virus is highly contagious and infects and causes the stomach and intestines Vomiting and diarrhea. Most people recover within a few days, but very young people and older people, especially going to the hospital, costing a considerable amount of medical care. “In the US alone, it’s 10 billion.[dollar]- A problem of one year.” Shawn Tucker At Biotech Company Vaxart in San Francisco, California.

This has spurred scientists to develop vaccines, but so far, efforts have failed. This is because previous attempts focused on developing injectable vaccines. This isn’t very good for producing protective antibodies in the intestines where the virus replicates. Tucker says.

To deal with this, Tucker and his colleagues Previously developed oral norovirus vaccines This will supply proteins to the intestines from the Gi.1 norovirus mutant. The first trials in adults under the age of 50 found that tablets can produce norovirus-specific antibodies in the intestines, but it is probably not a vaccine priority given that people in this age group generally recover easily from the virus.

Researchers are currently testing vaccines in people in the US between the ages of 55 and 80. The team gave 11 people the pills, while the other 22 took the placebo. About a month later, the researchers collected blood and saliva samples from the participants.

They found that people who took the vaccine had higher levels of IgA antibodies. These antibodies were increased by more than 10 times in the blood and about 7 times in saliva compared to samples just before vaccination. In contrast, the placebo group showed little change in antibody levels.

Importantly, antibodies are still present in people who took the pills, albeit at lower levels after 6 months, suggesting that they can provide permanent immunity. “The fact that they have this robust antibody response makes me hope that it can provide protection. [against infection]”I say Sarah Cady At Cornell University in New York. “In particular, the salivary antibody response is a way to get a snapshot of what’s going on in the intestines because of similar immune responses,” she says.

However, further research should investigate whether the vaccine actually prevents infection or reduces spread spread of norovirus, she says. The team wants to explore this.

Furthermore, this study focused only on one norovirus variant. “In the real world, there are a number of different strains you may encounter. The vaccine may not protect all of them,” says Caddy. In an unpublished study, researchers found that versions of vaccines containing both Gi.1 and Gii.4 norovirus variants (the latter currently surges in the UK) produce antibodies against multiple variations.

This suggests we may soon have norovirus vaccines, Tucker says. “If there’s no funding hiccups, if everything goes smoothly, the vaccine could be available in a few years,” he says.

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Source: www.newscientist.com

The brain’s waste removal process disrupted by sleeping pills

During sleep, your brain eliminates toxins that have accumulated throughout the day.

Robert Reeder/Getty Images

Sleeping pills may help you doze off, but the sleep you get may not be as restorative. When mice were given zolpidem, which is commonly found in sleeping pills such as Ambien, their brains were unable to effectively remove waste products during sleep.

Sleep is important for removing waste from the brain. At night, a clear fluid called cerebrospinal fluid circulates around brain tissue and flushes out toxins through a series of thin tubes known as the glymphatic system. Think of it like a dishwasher, which turns on your brain while you sleep, says Miken Nedergaard at the University of Rochester Medical Center in New York. However, the mechanisms that push fluid through this network have not been well understood.

Nedergaard and his colleagues implanted optical fibers into the brains of seven mice. By irradiating chemicals in the brain, the fibers can track the flow of blood and cerebrospinal fluid during sleep.

They found that elevated levels of a molecule called norepinephrine cause blood vessels in the brain to constrict, reducing blood volume and allowing cerebrospinal fluid to flow into the brain. As norepinephrine levels decrease, blood vessels dilate and cerebrospinal fluid is pushed back. Thus, fluctuations in norepinephrine during non-rapid eye movement (NREM) sleep stimulate blood vessels to act like pumps in the glymphatic system, Nedergaard said.

This discovery reveals that norepinephrine plays an important role in clearing waste from the brain. Previous research has shown that when we sleep, the brain releases norepinephrine in a slow, oscillating pattern. These norepinephrine waves occur during NREM, a sleep stage important for memory, learning, and other cognitive functions.

Next, the researchers treated six mice with zolpidem, a sleeping pill commonly sold under the brand names Ambien and Zolpimist. The mice fell asleep faster than those treated with a placebo, but the flow of cerebrospinal fluid in the brain was reduced by about 30 percent on average. In other words, “their brains aren't being cleaned very well,” Nedergaard said.

Although zolpidem was tested in this experiment, almost all sleeping pills inhibit the production of norepinephrine. This suggests that they may interfere with the brain's ability to eliminate toxins.

It is too early to tell whether these results apply to humans. “Human sleep architecture is still quite different from mice, but they have the same brain circuits studied here,” he says. laura lewis at Massachusetts Institute of Technology. “Some of these basic mechanisms may apply to us as well.”

If sleeping pills interfere with the brain's ability to eliminate toxins during sleep, Nedergaard says, that means new sleeping pills must be developed. Otherwise, your sleep problems may worsen and your brain health may deteriorate in the process.

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Source: www.newscientist.com

Debunking the Multivitamin Myth: How Pills May Hurt Your Immune System

The immune system is a complex network of cells, proteins, and organs that acts as the body’s last line of defense against infection. Maintaining a healthy immune system is crucial for overall well-being.

While there are numerous supplements and products available to boost immune function, it’s important to understand that the immune system is a well-regulated system that typically functions optimally when you lead a healthy lifestyle.

Misconceptions about increasing immunity

Boosting immunity may seem like a good idea in theory, but in reality, the immune system is equipped to function efficiently on its own with the right lifestyle habits.

Attempting to supercharge the immune system with supplements can have negative consequences, as excess immune cells can lead to autoimmune diseases and other health issues.

According to Dr. Bobby Cherail, an expert in immunology, living a healthy lifestyle through proper diet, exercise, and avoiding harmful habits is the best way to support the immune system.

It’s important to note that the immune system may weaken with poor lifestyle choices, but infections typically occur only in extreme cases of malnourishment or deficiency.

Potential risks of vitamin supplements

While vitamin supplements may seem like a harmless way to boost immunity, there are risks associated with overconsumption of certain vitamins, such as vitamin A, D, E, and K.

Excess water-soluble vitamins are generally excreted by the body, but fat-soluble vitamins can accumulate and lead to toxicity if consumed in excess.

Studies have shown that multivitamins may not provide significant health benefits and can lead to a false sense of security, causing individuals to neglect other aspects of their health.

Long-term use of multivitamins has been linked to an increased risk of certain health conditions, especially in older individuals.

Vitamins still play a role…for some people.

While a healthy lifestyle is typically sufficient for maintaining a strong immune system, certain individuals with vitamin deficiencies may benefit from supplements.

People with difficulty chewing, swallowing, pregnant women, and those with digestive issues may require additional vitamin support to maintain optimal health.

Ultimately, the immune system is a highly efficient self-regulator, and for most people, immune-boosting supplements may not offer significant benefits.


About our expert Bobby Shereyle

Dr. Bobby Cherail is an associate professor of pediatrics at Harvard University, specializing in immunology and the immune system’s response to infection and inflammation.

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Source: www.sciencefocus.com

Telemedicine and doctor’s office have the same safety for abortion pills.

Abortion pill pills contain mifepristone and misoprostol

Brigette Supernova / Alamy

Abortion pills are just as safe and effective when obtained through telehealth services as they are when obtained in a doctor's office, according to the largest study ever on telemedicine abortions.

Access to abortion is a contentious political issue in the United States. In 2021, the U.S. Food and Drug Administration (FDA) eliminated in-person dispensing requirements for the abortion drug mifepristone, allowing people to obtain the pill through telehealth services or by mail. Anti-abortion groups are currently challenging this ruling in the U.S. Supreme Court.

Previous studies of hundreds of pregnancies have shown that telemedicine abortions are safe. For further investigation with a larger sample size, Ushma Upadhyay Researchers from the University of California, San Francisco, collected data on more than 6,000 telemedicine abortions performed in 20 U.S. states and Washington, DC. All participants were less than 10 weeks pregnant, and approximately 72% of them obtained the abortion pill through a secure text message rather than a video call.

The researchers followed the participants for three to seven days after the abortion, and then again two to four weeks later. The research team found that nearly 98 percent of abortions effectively ended the pregnancy. Additionally, only 0.25 percent of participants experienced serious side effects, such as uncontrolled bleeding or infection. By comparison, personal use of mifepristone is more than 97% effective and has a 0.3% chance of causing adverse events. There was also no difference in outcomes between abortions obtained via text message or video.

“These findings are consistent with the growing body of evidence that mifepristone is safe and effective and that FDA's decision to eliminate the in-person dispensing requirement was scientifically sound.” says Upadhyay.

“The outcomes for patients who come to telemedicine and brick-and-mortar clinics are essentially indistinguishable,” he says. samuel dickman at Planned Parenthood of Montana, a reproductive health nonprofit. Telemedicine abortions are essential to providing care to rural populations and people who are uncomfortable going to an abortion clinic because of an abusive partner, he says.

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Source: www.newscientist.com