Why Exercise Alone May Not Be Effective for Weight Loss: Key Insights

Benefits of Exercise vs Weight Loss

Exercise has numerous benefits, but weight loss might not be one of them.

Jeffrey Isaac Greenberg 5+/Alamy

Engaging in regular exercise is extremely beneficial for overall health; however, it may not effectively lead to weight loss. Recent studies provide compelling evidence explaining this phenomenon.

While individuals who up their exercise routine often burn extra calories, weight loss usually doesn’t align with the caloric expenditure expected. A meta-analysis of 14 trials indicates that our bodies often compensate by reducing energy expenditure in other activities.

Notably, the compensatory effects are pronounced when one combines reduced caloric intake with increased exercise, effectively negating the hoped-for weight loss benefits of physical activity. In simpler terms, while dietary restrictions can lead to weight loss, increasing exercise alongside dieting may yield minimal additional benefits.

“The real challenge here is that when you combine exercise and dieting, the body compensates more aggressively,” explains Herman Pontzer of Duke University, North Carolina. “Exercise is still beneficial, but weight loss isn’t guaranteed.”

In his research on the Hadza hunter-gatherers of Tanzania, Pontzer found that despite their high activity levels, they did not expend more energy than sedentary individuals. This led him to propose, back in 2015, that our bodies may have evolved to conserve energy through reduced expenditure when faced with increased physical activity.

Although some studies support this compensation theory, not all experts agree. Pontzer and fellow researcher Eric Trexler at Duke have examined existing studies that were designed for other purposes, ensuring their analysis was unbiased. They analyzed 14 trials involving around 450 participants—small due to the rigorous methods needed to monitor total energy expenditure.

Their findings revealed an average energy expenditure increase of only one-third of expectations based on increased physical activity levels. For instance, if a person’s workout routine burns an additional 200 calories daily, these trials reported an overall increase of only about 60 kilocalories.

Interestingly, the results varied significantly. Those who maintained their caloric intake saw about half of the expected increase in total energy expenditure, while individuals who increased their physical activity while reducing their caloric intake often did not observe any significant changes. “They’re exercising 200 calories a day but seeing no tangible results,” Pontzer noted.

The type of exercise also plays a crucial role; compensation predominantly occurs during aerobic activities like running. In contrast, strength training appears to result in greater-than-expected energy expenditure. For example, individuals who burn an extra 200 calories from weightlifting tend to increase their total energy expenditure by approximately 250 calories per day.

However, Pontzer advises caution in interpreting these findings, as energy expenditure measurement during weight training can be challenging. He hypothesizes that weightlifters may deplete energy while repairing and building muscle tissue.

Initially, Pontzer believed the type of exercise might be negligible, but he now finds the insights exciting as they reveal unrecognized aspects of energy compensation. Despite the gains in muscle, weightlifting participants exhibited minimal fat loss, indicating it may not be a practical approach for weight loss.

So, why does an increase in aerobic exercise not lead to expected increases in energy expenditure? This analysis suggests that the body compensates by reallocating energy expenditures across various systems. For instance, the resting metabolic rate, particularly during sleep, can decrease with increased aerobic activity.

“Our body adjusts how different organ systems function post-exercise,” Pontzer says. “Understanding these changes could provide insights into how exercise benefits different individuals unequally.”

While Pontzer’s findings provide support for energy compensation, skeptics remain. Researcher Dylan Thompson from the University of Bath emphasizes the results of a meta-analysis suggesting aerobic exercise does not significantly affect resting metabolic rates.

Additionally, there might be critical research limitations, as pointed out by Javier Gonzalez, also at the University of Bath. For example, additional exercise might replace other daily activities like gardening, which could account for the lack of increased energy expenditure.

Nevertheless, Pontzer asserts that some studies effectively rule out this possibility, as compensation effects have also been documented in animal studies, corroborating human findings. Nonetheless, Thompson and Gonzalez argue for the necessity of more rigorous studies. “We require meticulously designed randomized controlled trials involving humans,” Thompson concludes.

Topics:

Source: www.newscientist.com

Revolutionary Weight Loss Drug Launch: The Ultimate Solution is Here!

Ozempic is a well-known name, primarily approved for diabetes treatment in the UK and US, yet it is commonly prescribed ‘off-label’ for weight loss. This medication has essentially become synonymous with a groundbreaking new category of weight loss drugs.

Injectable medications like Ozempic, Wegovy, Mounjaro, Zepbound, Rybelsus, and Saxenda can facilitate significant weight loss, approaching 20% of a person’s body weight in certain individuals.

Now, the next generation of weight loss solutions has arrived, and they are available in pill form.

The debut of these tablets occurred in the United States, with Novo Nordisk (the producer of Ozempic) launching Wegovy tablets on January 5, 2026. Their quick rise in popularity resulted in over 18,000 new prescriptions issued in the first week alone.

But Wegovy won’t stand alone for long. Eli Lilly’s competing drug, orforglipron, is projected to gain FDA approval this spring, and several alternatives are in development.

(Currently, these tablets are not available in the UK; however, UK policies are anticipated to follow the FDA’s example.)

The mechanism of these tablets mirrors that of injectables. The active compounds, known as “incretins” (like Wegovy’s semaglutide and Mounjaro’s tirzepatide), deceive the body into feeling full by imitating natural satiety hormones.

As digestion slows down, you naturally consume less, leading to weight loss. Don’t let hunger hinder your journey to success.

Now available in pill form, this medication promises similar life-altering effects and protection against obesity-related illnesses, all while being more affordable than ever.

Is it too good to be true? Experts caution that while the pill presents notable risks, it also brings substantial benefits.

Read more:

Can Weight Loss Drugs Transform the Landscape of Treatment?

These tablets could signify a new chapter in the management of obesity, providing broader access to life-altering healthcare.

“Not everyone prefers injectable medications,” states Dr. Simon Cork, a senior lecturer in appetite and weight regulation at Anglia Ruskin University in the UK. “Injections can be uncomfortable for many patients, making oral administration a more appealing option.”

Besides comfort, switching from injections to pills could massively reduce monthly costs. Those using weight loss drugs today often spend hundreds of dollars each month on injections.

Weight loss pills can be stored at room temperature in standard pill blister packs, making them more accessible – Credit: Getty Images

Thanks to the absence of needles and refrigeration needs, these pills can be produced and distributed at lower costs, providing weight loss solutions to millions who previously faced exorbitant prices.

“Overall, these pills are expected to be significantly more affordable than current injection therapies,” says Cork.

This trend is already visible in the US, where Wegovy pens are priced at $349 (approximately £250) per month, whereas Wegovy tablets retail for $149 (around £110).

In the UK, nearly 95% of incretin users incur high private fees. According to Professor Giles Yeo from the University of Cambridge, the NHS often cannot prescribe these expensive medications to all patients who need them.

“Patients may need to maintain these drugs for extended periods, which exacerbates the financial barrier, particularly for those from disadvantaged backgrounds most susceptible to obesity,” Cork noted. “I hope that these oral medications will democratize access.”

Addressing Long-Term Challenges

However, these drugs may not be the most effective options, even as their availability increases.

Incretins tend to offer lower efficacy in pill form. Injectable Wegovy has demonstrated a capacity to help users lose 15% of body weight after 68 weeks, while Wegovy tablets showed only 13.6% weight loss across 64 weeks.

The efficacy of pills may not match that of modern injected solutions. Retatortide, still in development, has shown results of 24% body weight reduction in just 48 weeks.

Administering these drugs through pills poses inherent challenges. Oral medications must traverse the stomach and liver before entering circulation, resulting in the manufacturer needing to increase the amount of active ingredient to achieve desired outcomes.

Consequently, weight loss results from pills may not be as rapid as from injections. Nevertheless, a significant complaint regarding injections—that discontinuing them often leads to weight regain—may see improvement.

A 2022 study revealed that participants who halted Wegovy injections regained up to two-thirds of their lost weight within one year.

The emergence of the pill could provide a solution. A recent study, the Eli Lilly ATTAIN-MAINTAIN Trial, showed that Orforglipron tablets helped participants stabilize their weight after stopping injectable therapy.

“Many might rely on these medications to maintain weight loss,” Yeo suggests.

Cork adds, “Injectables can be utilized for optimal weight loss, and pills can help maintain this weight affordably.”

Most incretins mimic the natural satiety hormone GLP-1, but new treatments are targeting multiple hormones for enhanced effectiveness – Credit: Getty Images

The Risks and Concerns of the Pill Revolution

While these drugs possess the potential to catalyze significant positive change, their widespread availability also raises risks for vulnerable populations.

“The major danger is these drugs entering the wrong hands,” warns Yeo. “Since there’s no weight limit to how these drugs might impact individuals, a 300-pound person aiming to lose 50 pounds could utilize it as well as a 16-year-old girl weighing 75 pounds.”

“Pills can easily be trafficked, making them accessible to anyone. It’s essential to establish strict regulations around their distribution,” he urges.

Cork shares concerns over side effects. Incretins can provoke various symptoms, including nausea, vomiting, constipation, and diarrhea. Clinical trials found that three-quarters of participants experienced digestive issues.

Moreover, there are rare but serious risks such as pancreatitis, gallstones, and gastroparesis. Additionally, interactions with other medications, including contraceptives, could affect their efficacy.

“The risk of pancreatitis is low, around 1%,” Cork notes. “But with millions potentially using these drugs, this risk becomes concerning without appropriate oversight.”

Though these warnings are sobering, they remain speculative. The actual impact of these drugs is still uncertain.

“2026 is poised to be a crucial year in understanding the efficacy, prevalence, and applications of these medications,” Yeo concludes. “Time will tell how things unfold.”

Read more:

Source: www.sciencefocus.com

Polar Bears Increasingly Thrive in the World’s Hottest Regions: A Study on Weight Gains

Polar bears in Svalbard

Researchers Monitor Polar Bears’ Body Condition in Svalbard

John Earls, Norsk Arctic Institute

In the Svalbard archipelago of Norway, a region known for its climatic extremes, polar bears are surprisingly gaining weight despite the alarming reduction of sea ice. However, scientists warn this trend may not be sustainable.

The northern Barents Sea, located between Svalbard and Russia’s Novaya Zemlya, is warming disproportionately—seven times faster than the global average. Over the past two decades, sea ice around Svalbard has diminished, disappearing two months earlier each year. Currently, polar bears must swim over 200 kilometers between their hunting grounds and birthing caves.

<p>Despite this challenging environment, the overall size and weight of Svalbard’s polar bears has increased since 2000, presenting a puzzling contradiction. <a href="https://www.researchgate.net/profile/Jon-Aars-2">Jon Aars</a>, who led the research at the Norwegian Polar Institute, claims it's positive news for Svalbard. However, he cautions that areas most affected by climate change show severe decline in polar bear populations.</p>

<p>This widely dispersed solitary predator counts among its many challenges the difficulty of accurate population estimates. The numbers <a href="https://www.iucn-pbsg.org/wp-content/uploads/2024/11/PBSG-Status-Criteria-and-Report_Final_2024Oct7.pdf">are declining</a> in some regions while stable or even increasing in parts of Alaska, Canada, and Greenland; for nine populations, data remains insufficient.</p>

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<p>Estimations suggest the Barents Sea bear population ranges from 1,900 to 3,600 individuals, and appears stable or potentially increasing. From 1995 onward, researchers used tranquilizers via helicopter to study 770 bears, measuring their body length and thorax circumference to approximate weight.</p>
<p>Analysis of trends demonstrated a decline in body condition until 2000, followed by a gradual increase leading up to the last assessments in 2019.</p>

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                <p class="ArticleImageCaption__Title">Crucial Role of Sea Ice in Polar Bear Survival</p>
                <p class="ArticleImageCaption__Credit">Trine Lise Sviggum Helgerud, Norsk Arctic Institute</p>
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<p>In spring, the birth of seal pups on sea ice provides a vital food source for polar bears, allowing them to build fat reserves for the warmer months. Researchers like Earls speculate that diminishing ice may actually assist bears in hunting seals more easily.</p>
<p>With the retreating ice, bears are adapting by exploring new food sources. The approximately 250 bears remaining on Svalbard may increasingly hunt bearded and harbor seals along the coast, while thriving walrus populations might offer additional sustenance.</p>
<p>These adaptable "local bears" are now raiding nesting colonies for bird eggs and chasing reindeer, showcasing a remarkable resilience. According to researchers, such flexibility may be delaying their extinction, says <a href="https://www.researchgate.net/profile/Jouke-Prop">Jouke Prop</a> of the University of Groningen.</p>
<p>"This is a desperate tribe. They're doing unique things," he notes. "While this adaptability may not apply universally, it could suffice for a while in Svalbard."</p>
<p>Although polar bears have not yet reached Svalbard's ecological limits, thanks to the prohibition of hunting since 1973, warming temperatures threaten to disrupt the delicate food chain that begins with algae on sea ice, according to Prop.</p>
<p>"Should the sea ice vanish, sustaining a significant number of polar bears will become incredibly challenging," he warns.</p>
<p>"There exists a threshold beyond which continuous sea ice loss will negatively impact polar bears in Svalbard," Aars adds.</p>

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                 alt="Explore Northern Norway" 
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            <h3 class="SpecialArticleUnit__Heading">Uncover the Beauty of Svalbard and Tromsø</h3>
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                <p>Embark on an adventurous journey to Norway's Arctic region. Discover the scientific marvels behind the Northern Lights, the unique Arctic ecosystem, and how humans adapt to the challenges of the Far North.</p>
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    <p class="ArticleTopics__Heading">Topics:</p>
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Source: www.newscientist.com

Weight Regain: What to Expect After Discontinuing Obesity Medications in Two Years

Weight loss drugs effectiveness

Weight loss medications, including Munjaro (tirzepatide), are effective when taken consistently.

Alan Swart / Alamy

A recent study involving over 9,000 participants revealed that individuals who discontinue weight loss medications often regain the weight lost within two years. This finding underscores the notion that obesity should be viewed as a chronic disease necessitating ongoing treatment.

“These medications are very effective; however, obesity is a chronic, relapsing condition,” explained Susan Jebb, who addressed the press at the University of Oxford. “Similar to hypertension medications, these treatments are likely needed for life.”

It’s evident that weight loss medications can significantly aid individuals in combating obesity, particularly newer GLP-1 medications mimicking gut hormones such as glucagon-like peptide 1—examples include semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound). These drugs not only facilitate weight loss but also positively impact health metrics like blood pressure and cholesterol levels.

Nevertheless, many patients have ceased using GLP-1 medications due to side effects, including nausea, or a lack of availability triggered by heightened demand. “Approximately half of users discontinue these drugs within a year,” remarks Jebb.

While nations like the United States and parts of Europe permit long-term use of GLP-1 medications for weight control, frameworks like the UK’s National Health Service are restricting semaglutide usage for weight management based on cost-effectiveness evaluations over two years.

Previous studies indicate that individuals often regain weight post-semaglutide discontinuation. Yet, it remains unclear if this pattern extends to other weight loss interventions and the swift occurrence of weight gain upon cessation.

To investigate this, Jebb and colleagues reviewed 37 trials, combining data from over 9,000 participants, all classified as overweight or obese and using some form of weight loss medication (including GLP-1) for about 10 months, followed by a monitoring period of roughly 8 months.

From their analysis, the researchers noted that participants lost an average of 8.3 kilograms and experienced improvements in metabolic parameters like blood pressure, cholesterol, and blood glucose levels.

When examining weight patterns during the follow-up phase, the model suggested participants regained the average weight lost within 1.7 years after stopping their medications.

In trials specifically addressing semaglutide and tirzepatide, participants lost an average of 14.7 kilograms, yet it was anticipated they would regain all lost weight within a year and a half. Jebb points out that further insights are required to understand the accelerated weight gain associated with these drugs compared to others.

Additionally, the team discovered that the weight regain rate after ceasing weight loss drugs was about four times steeper than that observed following the termination of a structured behavioral weight loss program, which typically emphasizes healthy eating and increased physical activity.

However, this disparity may be attributed to the greater motivation for weight loss among individuals participating in behavioral programs compared to those relying on medications.

Another factor contributing to this swift weight regain may be the appetite suppression induced by these drugs. Users often report significant increases in hunger and cravings upon discontinuation, possibly leading to rapid weight resurgence, as noted by Taraneh Soleimani from Pennsylvania State University.

Yet, a separate analysis suggested that offering behavioral support during the follow-up phase did not effectively curb weight gain. Soleimani emphasizes that more research is essential to determine optimal strategies for supporting individuals transitioning off weight loss medications.

What Jebb’s research illustrates, according to her, is the critical need to consider obesity as a long-lasting condition. “Weight loss drugs demonstrate effectiveness, and weight regain is prevalent upon cessation,” states Professor Soleimani. “These results confirm obesity as a chronic condition that requires prolonged treatment.”

Topics:

  • obesity/
  • weight loss drugs

Source: www.newscientist.com

2026: The Next Landmark Year for Breakthrough Weight Loss Medications

Travel Pix Pro/Getty Images

Many individuals set New Year’s resolutions to lose weight, particularly following the holiday festivities. Traditionally, this involved adopting a new diet, waking up early for workouts, and other habits that can be challenging to sustain. Consequently, it’s no surprise that numerous people abandon their goals within weeks.

Today, however, an alternative has emerged: weight loss medications. Instead of solely depending on lifestyle changes, individuals can benefit from regular doses of GLP-1 agonists or other therapeutic tablets (as highlighted on page 6). Health professionals still recommend integrating these medications with consistent physical activity for optimal results.

GLP-1 drugs are not only transforming our cyclical health regimens. Restaurants are now crafting menus specifically for Ozempic diners, featuring smaller portion sizes for customers who experience reduced appetite. Additionally, supermarkets have reported declines in sales due to decreased demand from those using these medications. Airlines are also considering the implications, as decreased average passenger weight could lower fuel expenses.

While it’s unclear how much these trends can be attributed to GLP-1 drugs—which are currently used by a minority—and the extent of their impact on brands reacting to this health trend, the statistics surrounding obesity are alarming. Approximately 1 billion individuals globally are affected by obesity, and the adoption of these medications is expected to rise. According to World Health Organization estimates, fewer than 10 percent of people will utilize GLP-1 drugs by 2030, yet this still represents a substantial demographic.


Restaurants are designing menus featuring reduced portions for Ozempic diners.

New advancements in medication are in development (refer to page 7), and the potential impacts could be even more significant. Beyond weight reduction, GLP-1 agonists have shown promise in treating various conditions, from addiction to eye diseases like cataracts.

While there remain numerous uncertainties regarding the long-term consequences, the results of discontinuation, and enhancing accessibility, the future appears bright. As we advance further into the 21st century, weight loss drugs are poised to play a crucial role in shaping health and wellness trends.

Topics:

Source: www.newscientist.com

Essential Science-Backed Metabolic Strategies for Effective Weight Loss

If you’ve struggled with weight loss, you may have attributed it to your metabolism. This elusive concept seems to make losing weight effortless for some, while for others, it feels like an uphill battle.

However, this perception misrepresents how the body truly functions, neglecting the critical elements of fat loss.

Metabolism encompasses more than just “the number of calories burned.” It’s a complex network of chemical reactions occurring in your cells and tissues that power everything you do.

Many individuals simplify it to a single statistic: calories burned at a specific moment.

Here, “metabolic rate” becomes relevant. It’s the standard metric for gauging how quickly your metabolism operates. Essentially, it’s the energy expended at rest, representing the minimal energy required to keep bodily functions active.

A common belief is that lean individuals possess a “fast” metabolism, burning more calories effortlessly. In fact, larger bodies often exhibit a “faster” metabolism.

The metabolic rate largely hinges on body size—greater tissue requires more energy for maintenance.

However, weight alone is a rudimentary gauge. Two individuals may weigh the same, but differences in fat-to-muscle ratios can significantly influence their metabolic rates.

Lean mass, particularly organs, plays a pivotal role in energy expenditure. The liver and brain alone contribute about half of the body’s resting energy requirements, with the kidneys accounting for nearly 20 percent.

Though skeletal muscle has a lower metabolic activity than organs (approximately 20 times less active per gram), its substantial mass contributes significantly to resting energy expenditure.

Since organ masses are consistent among individuals of similar size, muscle and fat primarily dictate metabolic variations.

This distinction also elucidates the differences between men and women. Men generally have a higher muscle mass and lower fat percentage, leading to a greater metabolic rate at the same weight.

Once body composition and gender are factored, metabolic rates prove to be surprisingly predictable, challenging the notion that some individuals have substantially “faster” metabolisms than others.

Deceleration Myth

Age-related hormonal changes often promote fat gain – Photo credit: Getty

There’s a common belief that metabolic rates decline with age. However, this perception may not hold, particularly for middle-aged individuals.

Taking body composition into account, metabolic rates typically remain stable until about age 65. The earlier drop is more related to shifts in muscle and fat than a mysterious “aging metabolism.”

Changes in hormonal balance, particularly during menopause, can impact metabolism.

Hormonal changes often promote fat gain while contributing to muscle loss, particularly around the abdomen, both of which can lower metabolic rates.

Additionally, reduced estrogen levels can affect thermogenesis, potentially slowing metabolism and leading to hot flashes.

After age 65, energy expenditure tends to diminish, not because of metabolic “aging,” but due to broader physical changes.

Muscle mass typically declines faster, lessening both muscle and organ metabolic activity, resulting in lower calorie burning.

The good news? Staying active, eating healthily, and preserving muscle mass can help mitigate muscle loss.

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Built-in Balance Adjustment Function

If metabolism is mostly predictable, can it be entirely fixed? Not quite. Depending on circumstances, your body can gradually adjust its calorie burn.

For instance, someone who is overweight naturally burns more calories due to increased tissue maintenance. Research suggests their bodies might slightly ramp up calorie burning to eliminate excess weight.

Conversely, underweight individuals may consume fewer calories than anticipated because their metabolic rates decrease further, becoming very conservative with energy usage.

How does this occur? Some studies propose that the body can intentionally waste energy by generating heat, a process known as adaptive (or conditional) thermogenesis.

This process involves specialized fat cells called brown fat and certain proteins in muscles and other tissues, which can “leak” more (or fewer) calories as heat instead of storing them.

This heat dissipation is subtle—not felt as sweat or fever—but is a behind-the-scenes adjustment that fine-tunes energy balance.

Brown fat, or adipose tissue, burns energy to regulate body temperature – Photo credit: Getty

Adaptive thermogenesis does not mean being confined to a fixed body weight. This explains why dieting can feel like swimming against the tide. When calorie intake is cut, the body often retaliates by slowing metabolism, making it harder to sustain progress.

This leads to a pressing question: Can you truly change your metabolism, and if so, what methods are effective?

There Is No Magic Menu

You may have encountered claims that certain foods, like caffeine, polyphenols from spicy foods, or chili pepper extract, “boost” metabolism and increase calorie burn through thermogenesis.

However, the actual calorie increases from these ingredients are minimal, detectable only for short periods—lasting mere minutes to hours.

Another suggestion is to increase protein intake to speed up metabolism.

The premise is that digesting and absorbing protein requires more energy than digesting carbohydrates and fats, potentially resulting in fewer overall calories gained. However, this difference in calorie burn is often negligible.

While increased protein can help maintain and build muscle—supporting a higher metabolic rate—muscle growth is not solely reliant on protein.

Muscle repair and growth are stimulated primarily through exercise, especially resistance training.

In fact, exercise and physical activity are key to enhancing caloric usage, increasing your metabolism.

Moreover, exercise generates additional metabolic benefits beyond just the calories burned during the activity. Post-exercise, metabolism recovers at an accelerated rate as muscles adapt to the workout’s demands.

This phenomenon is known as excess post-exercise oxygen consumption (EPOC), commonly recognized as the “afterburn” effect.

This temporary spike in fuel and calorie usage can last for several hours, even up to 48 hours, particularly after workouts focused on muscle repair and growth.

While it may not be the shortcut many seek, when targeting metabolism and fat loss, exercise—particularly strength-building workouts—remains a far more effective strategy.

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Source: www.sciencefocus.com

Projected Decline in Weight Loss Drug Prices by 2026: What You Need to Know

Massive demand for weight loss medications

Surge in demand for drugs like Wegovy, Victoza, and Ozempic leads to shortages

Michael Silk/Alamy

The blockbuster weight loss drug semaglutide, along with competitors, offers potential solutions to the global obesity crisis. However, access remains limited for many who could greatly benefit from these innovations, though changes are on the horizon.

Historically, weight loss drugs have been scarce; yet, by the end of 2024, manufacturers are expected to meet the skyrocketing demand. Nevertheless, treatments like semaglutide (marketed as Wegovy or Ozempic) continue to carry hefty price tags, often reaching thousands of dollars annually.

This pricing structures keeps these essential medications out of reach for the over 1 billion individuals affected by obesity globally. In the U.S., a mere 3 percent of the population utilizes weight-loss medications, with the numbers dipping below 1 percent in other countries, according to Morgan Stanley.

Looking ahead, 2026 promises significant developments, including the approval of orforglipron in multiple countries. This new medication mimics the GLP-1 hormone, known for its appetite-reducing properties. Unlike semaglutide, orforglipron, as a small molecule, offers tablet-based administration.

“Tablets are inexpensive to produce, simple to store, and easy to distribute,” explains Dr. Laura Heisler from the University of Aberdeen, UK. “In essence, the medication can reach a broader audience in need.”

In contrast, semaglutide is a larger molecule and a type of protein. Polymer drugs like these are generally challenging and costly to produce. They often require injections, complicating their supply and driving up costs. This has been a significant barrier to fulfilling the demand for GLP-1 drugs.

It’s important to note that there is a semaglutide version in pill form, Rybelsus, approved for type 2 diabetes. Novo Nordisk, the manufacturer, has also sought approval for a weight loss variant.

However, Rybelsus isn’t just any medication; it includes semaglutide alongside sulcaprosate sodium, which neutralizes stomach acid to facilitate absorption into the bloodstream. To maximize effectiveness, it must be taken at least 8 hours post-meal, with no food or drink for 30 minutes.

This complexity is part of the reason orforglipron has a lower production cost compared to semaglutide—it can be taken without the stringent requirements of medications like Rybelsus.

Furthermore, the introduction of orforglipron will foster competition among pharmaceutical companies. While Lilly, the producer of Orforglipron, has yet to disclose pricing, it has been shown to be less costly than other GLP-1 alternatives.

The sole drawback is that orforglipron appears less effective; those on the highest doses typically lose about 10% of body weight over 72 weeks, compared to 14% with semaglutide. Further research is needed to validate these findings.

Another critical development is the anticipated expiration of semaglutide patents in nations such as China, India, Brazil, Canada, and Turkey—home to a significant population. This could pave the way for generic versions to enter the market.

Although generics must meet the same standards as their branded counterparts, they often come at a fraction of the cost. “Once a drug loses patent protection, generic competition usually leads to price reductions of up to 90%,” states Jeremy Durant of Medicines UK, the association for generic drug manufacturers.

This shift may expand access to these crucial treatments. That said, the World Health Organization (WHO) recently advised that patients should also receive counseling about behavioral modifications and lifestyle changes to maximize the efficacy of medications. “Drugs alone won’t address the global obesity crisis,” says Francesca Ceretti of WHO.

Topics:

Source: www.newscientist.com

2026 Weight Loss Drug Set to Outperform Ozempic and Zepbound: What You Need to Know

Innovative Weight Loss Treatments

Achieving a Healthy Weight: A Future of Possibilities

Merch Hub/Shutterstock

Recent advancements in obesity treatments have introduced highly effective medications, with the prospect of even more potent experimental treatments set for testing in 2026.

“We are witnessing an ambitious new phase in obesity treatment that promises improved health outcomes for numerous patients,” states Laura Heisler from the University of Aberdeen, UK. “Obesity is linked to severe health complications, including cancer, heart disease, and type 2 diabetes. A modest 5% reduction in body weight can significantly decrease these health risks.”

The first major weight loss drug, semaglutide, was initially approved as a diabetes treatment in 2017 under the name Ozempic. In 2021, it received approval for weight management as Wegovy.

Semaglutide functions by imitating the natural hormone GLP-1, which binds to brain and pancreatic receptors, helping to curb appetite and slow gastric emptying. Alongside its weight loss benefits, semaglutide has demonstrated positive cardiovascular effects and potential in managing conditions like substance addiction. However, common side effects like nausea can lead to discontinuation of the drug.

In 2023, Tirzepatide, marketed as Mounjaro for diabetes, secured approval for weight loss under the name Zepbound. Enhancing semaglutide’s effectiveness, Tirzepatide operates by mimicking both GLP-1 and another hormone, GIP, which is involved in energy management. Like semaglutide, it has comparable side effects.

In clinical trials, semaglutide resulted in an average weight reduction of 14% over 72 weeks, while participants using tirzepatide achieved a 20% reduction. Notably, regaining lost weight is common once the medication is stopped.

Looking ahead, more dual-action and even triple-action medications are in development. A promising candidate for 2024 approval is Kaglisema, which merges semaglutide with Caglilintide, a drug that stimulates fullness through amylin mimicry.

In a trial with over 3,400 adults, those taking Kaglisema achieved a weight loss of 20% after 68 weeks, outperforming both semaglutide (15%) and Caglilintide alone (12%), indicating strong potential.

Additionally, a drug named amicretin is undergoing development. Similar to CagliSema, it mimics both GLP-1 and amylin, but uses a single molecule that binds to both receptor types.

In preliminary trials involving 125 participants, amicretin users experienced an average weight loss of 24% after 36 weeks, suggesting superior effectiveness compared to tirzepatide, although final-stage trials won’t commence until 2026.

Moreover, the “triple G” drug letartortide activates three hormones to facilitate fat release: GLP-1, GIP, and glucagon. In a study of 338 individuals, those on the highest dose experienced an average weight loss of 24% after 48 weeks. Results from late-stage trials will be crucial for assessing letartortide’s approval timeline, expected in late 2026 or beyond.

It’s important to note that weight loss results from various clinical studies aren’t directly comparable due to differences in participant criteria, study durations, and dosages. Moreover, average results can mask significant variability in individual responses to GLP-1 drugs; while some experience negligible effects, others see remarkable weight loss.

As many as 100 new weight-loss drugs are currently in development for 2026 and beyond as companies strive to capture a share of the lucrative market. These innovations often focus on diverse combinations of existing targets, such as GLP-1, GIP, glucagon, and amylin receptors, or explore new mechanisms entirely.

Research is also addressing adverse effects, such as the evidence indicating some weight loss from GLP-1 drugs may come from muscle rather than fat. For instance, a recent trial earlier this year combined semaglutide with bimagrumab, a muscle growth inhibitor, seeking to counterbalance these effects.

“The prospect of emergent, highly effective drugs with fewer side effects is indeed exciting,” says Heisler.

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Source: www.newscientist.com

Daily Pills May Offer a Substitute for Weight Loss Injections

Pills may provide a more convenient method for taking weight-loss medications

H_Ko/Shutterstock

An oral pill could soon serve as an alternative to Wegovy and Ozempic injections after research demonstrated that it significantly reduces weight and enhances blood sugar levels in individuals with obesity and type 2 diabetes.

Created by the pharmaceutical giant Eli Lilly, Orforglipron mimics the action of semaglutide, the key ingredient found in Wigovy and Ozempic, by imitating a hormone known as GLP-1.

In a previous trial, researchers discovered that individuals who were obese but did not have type 2 diabetes could lose an average of approximately 11 percent of their body weight over 72 weeks while using Orforglipron. Although this is less than the 15% typically observed with similar treatments, many find the convenience of taking a pill more appealing. With semaglutide injections, the preference for oral medication becomes clear, as noted by Deborah Horn from the University of Texas.

To assess its effectiveness for those with obesity and type 2 diabetes, Horn and her colleagues enlisted over 1,600 individuals from ten countries, including India, Australia, China, Germany, Brazil, and the United States.

Approximately 900 participants were assigned to receive varying daily doses of orforglipron—low, medium, or high—while the remainder received placebo pills alongside lifestyle guidance.

After 72 weeks, individuals in the high-dose group lost nearly 10 percent on average, with 67 percent of that group achieving over 5 percent weight loss. The middle and low-dose groups recorded around 7 percent and 5 percent reductions, respectively, while the placebo group had less than a 3 percent decrease.

This study reaffirms that Orforglipron results in less weight loss compared to injectable GLP-1 medications; however, it may still enhance health and quality of life. Stefan Trapp from University College London, who did not participate in the study, remarked, “Even a modest 5% weight loss generally leads to clear benefits, such as increased exercise capacity, lifestyle changes, and reduced risk of other illnesses.”

Moreover, participants receiving high doses experienced an average drop of nearly 2 percent in blood sugar levels, with approximately 75 percent reaching levels typically aimed for diabetics, Horn shared. Conversely, those on lower doses saw a mere 0.1% reduction, while the placebo group exhibited no significant change.

Roughly 10% of the individuals taking high and medium doses had to discontinue use due to side effects like nausea, vomiting, and diarrhea—nearly double the occurrence seen in the low and placebo groups. Nonetheless, most participants deemed the side effects manageable, according to Horn. “The side effects were standard for other GLP-1 injectable medications,” she explained.

Horn mentioned that Eli Lilly anticipates the FDA will approve the drug for obesity and type 2 diabetes by early next year. As a physician, she hopes for approval of all three doses to provide patients with options to optimize their health while minimizing side effects.

Orforglipron does not necessitate refrigeration or syringes, which may lower manufacturing, storage, and distribution costs compared to injectable GLP-1 drugs. This, along with the elimination of injection-related discomfort, could enhance access to GLP-1 weight-loss drugs, which are currently costly and hard to obtain in many low- and middle-income nations, Trapp noted.

topic:

Source: www.newscientist.com

‘It Felt Disposable’: Models (Aged 27 and 62) Discuss Botox, Weight Loss, Creativity, and the Impact of AI

I
When we imagine models, they often appear as glamorous individuals who command high fees for their work. However, New York’s Daniel Maleka, 27, and London’s Dee O, 62, reveal that the reality is often a challenging quest for visibility.

The fashion industry is also rapidly evolving. Since O began her modeling career in 1983, the internet and social media have dramatically altered its dynamics. Currently, she’s adapting to trends such as:
AI models appearing in “VOGUE” and
the effects of GLP-1 weight loss drugs.
O and Maleka recently convened to reflect on their careers across different eras.

What’s your story?
D-O: I grew up in Birmingham, from a working-class Irish immigrant family. My boyfriend entered me in the “Face of 1983” contest without telling me. I was about 17 or 18 then. Out of the blue, Look Now magazine called, inviting me as a finalist in Birmingham. Though I didn’t win, the agency still wanted me to represent them, leading me to travel frequently from Birmingham and catch a bus from Victoria at 2 AM after a less than appetizing sandwich.




Composition: Christian Sinibaldi, The Guardian

Daniel Maleka: I was raised in New York by Guyanese-American parents and was inspired to model by watching America’s Next Top Model. Though my family urged me to focus on university first, I explored modeling a little during my teenage years. While studying public health at New York University and running track, a teammate who loved photography helped me take my first photos. As fashion week approached, we reached out to casting directors and designers via Instagram. I eventually signed with WeSpeak, a boutique agency founded by models.

How has your career evolved since then?
D-O:
At 29, I decided to step away from modeling for a regular job. I pursued education, but my daughter, now 27, inspired me to return to modeling, something I initially disliked. Five years later, I found my passion again and signed with Gray Agency, which offers a diverse range of models and continuing opportunities without the stress I once felt.

DM: After five years at WeSpeak, I felt I hadn’t reached my full potential, so I tried a more traditional agency for a year and a half. We clashed often, eventually parting ways. I found my way back to WeSpeak while scouting for a UK agent during a London show with a New York client. Many agencies don’t provide feedback, often leaving me to feel undervalued.




Danielle is wearing Christopher John Rogers’ Pre-Fall 2023 collection. Photo: Cesar Buitrago

Do: The situation is always murky! It’s challenging to navigate since I desire clarity, yet often, with competition being high, I wonder if I’m overlooked because there are countless others who resemble me.

Dee, how has modeling transformed since your initial days?
Do:
Back then, conversation was minimal. The agent handled all communications, often taking 20% commission. Models just needed to show up with looks. While there’s a surge of writers and stylists in the industry now, not all models fit the same mold. Leveraging platforms like social media is essential for job hunting today.

DM: I’ve cultivated a solid social media presence and experienced waves of viral moments during COVID-19. Much of my career has revolved around online networking and connections.

Does modeling affect how you perceive yourself?
DM:
Some shoots led me to question if others appreciated my looks. For a while, I struggled with my sense of beauty, which is quite a burden.

Do: It’s subtle but impactful. Prioritizing others’ needs and identity over our own can affect mental health significantly over time. When I began in the early 1980s, there was an evident class structure, making me feel like an outsider. There’s also the personal challenge of comparing oneself to other women.




Composition: Christian Sinibaldi, The Guardian

I think models are often seen and not heard, but does this lead to exploitation?
Do:
We witnessed predatory behaviors pre-MeToo in the ’80s. I was fortunate to have a strong voice, which made others wary of me. Yet, I recognized that social invitations might have led to more work, highlighting a power dynamic dominated by men, which made me feel expendable.

DM: I’ve always been progressive. At NYU, I collaborated with organizations on family planning and women’s rights. However, in that previous corporate environment, I often held back my opinions out of fear of agency rejection. Now, I advocate with the
Model Alliance, which fights for model rights. The
Fashion Worker Law passed in New York last year, enhancing protections. Despite this, I still see models being asked to sign contracts that exceed legal requirements, suggesting some continue to exploit the inexperience of newcomers.

Do: Absolutely, naivety, aspirations, and disillusionment.

DM: Joining the Model Alliance Worker Council comes with a warning: your agency could terminate you for being part of it. I had no idea such implications existed.

The Fashion Workers Act: What an impressive step forward!
Is progress occurring elsewhere?
Do:
There’s still a dominance of typical models in runway shows, often standing at 6 feet tall and size 8 or 6. Occasionally, I do see designers like
Ashish Gupta intentionally showcasing diverse models. His recent London Fashion Week show incorporated a troupe of dancers, a creative idea that excites me. It’s also gratifying to see growing awareness about ethical sourcing and environmental concerns in fashion, with greater salary attention for workers. I’m passionate about fashion and proudly represent vintage clothing.




JD Williams Dee model. Photo: JD Williams

DM: 2020 truly felt like a turning point in Black representation within modeling. After the Black Lives Matter protests, my bookings surged, creating a narrative of inclusivity. Now, however, it appears the trend is regressing, with fewer Black models in the spotlight. Additionally, I often find that stylists aren’t equipped to handle black hair, leading to detrimental outcomes, such as heat damage I experienced.

I’ve heard that models face pressure to remain thin. Have you experienced that?
Do:
I once knew a roommate who was an unhealthy size 12 in the UK (8 in the US). She lived on apples, battled rotting teeth, and suffered from bulimia, all in pursuit of agency approval for the desired height and size. Ultimately, she became sick and had to return home, a memory I’ll never forget.

DM: This issue has long affected model standards, and while I maintain a fit physique, I’ve gradually come to realize the pressures of being thinner. Initially, I was more muscular due to my athletics, but feedback like, “You need to change your dimensions,” during meetings hit me hard emotionally.

Do: Such standards have a profound impact on your mental state. Yet, we’re witnessing an emergence of diverse body shapes and sizes. Although it appears better than before, curvy models still face stereotypes, often expected to have hourglass figures.

With innovations like Botox and weight loss medications, have you noticed changes in the industry?
DM:
My peers who model plus sizes have expressed that these developments affect their runway bookings.


Do: On one job, they even taped my face to alter my skin. If my face isn’t good enough, why book someone older? These thoughts persist. I find myself torn about it; I have never undergone Botox or surgery, yet contemplate it. Models of my age at that shoot often shared similar feelings, emphasizing the contradictions we navigate.

Are you concerned about your images being used for deepfakes or AI training?
DM:
The Model Alliance included a clause in their legislation requiring written consent from models for such uses. There’s apprehension about the risk of my image being misused, especially with the vulnerability posed by sharing on platforms like Instagram.

Would you recommend modeling as a career?
DM:
Yes, it offers fulfillment and is often playful and fun, allowing you to embrace your inner child. However, if I had children, I’d prefer they start their modeling journey later, not at 15 or 16.

Do: I mirrored my parents’ approach with my daughter, insisting she finish college first. Nevertheless, her determination prevailed. I’m grateful for her resolve, especially as we now collaborate in the industry.




Photo: Christian Sinibaldi/Guardian

DM: I urge pursuing interests outside of modeling. After gaining recognition through TikTok, I perceived it as my sole identity for a while, which left me feeling disoriented.

Do: Traveling worldwide has been invaluable; even those experiences justify the journey. However, it’s critical to remember that success can vanish overnight.

Source: www.theguardian.com

Study Indicates That Certain Snacks May Contribute to Winter Weight Gain

Indulging in snacks rich in saturated fats during winter can mislead your body into accumulating more fat, as noted by recent findings.

Researchers at the University of California, San Francisco (UCSF) have uncovered that the types of dietary fat we consume can affect how our bodies recognize seasonal changes.

“Our research indicates that the food you eat plays a crucial role in informing your body clock about the time of year,” stated Dr. Dan Levin, a postdoctoral fellow in neurology at UCSF, in a conversation with BBC Science Focus.

They discovered that consuming more saturated fat—found in red meat, butter, cakes, pies, and various baked goods—activates a protein named PER2, signaling your body that it’s summer and that it needs to store energy for the forthcoming colder months.

Conversely, consuming unsaturated fats (present in nuts, seeds, fatty fish, and vegetable oils) influences PER2 to make your body believe it’s winter, prompting it to utilize the energy from food.

These conclusions arose from experiments where the UCSF researchers simulated seasonal transitions by altering light and dark periods for mice.

During the experiments that mimicked spring and fall, mice were exposed to 12 hours of light daily, 20 hours during summer, and only 4 hours in winter.

As the faux winter nights extended, the mice, on a balanced diet, exhibited normal nocturnal behaviors, such as running on wheels as darkness fell.

However, the mice on a high-fat diet took longer to wake up and began their running routine much later after the artificial sunset, indicating a misalignment of their internal clock with the simulated light conditions.

The scientists then assessed the impacts of various dietary fats. Mice consuming a diet abundant in saturated fat were found to wake up several hours later than their counterparts before engaging in physical activity.

Saturated fats are solid at room temperature and are found in butter, fatty meats, and many baked goods – Credit: Getty Images

As a result, increased saturated fat consumption during these simulated winter conditions appeared to further disrupt the synchronization of the body’s internal clock with the light cycles.

Professor Levin emphasized that, despite being conducted on mice, the relationship between dietary fats and the body clock via the protein PER2 is likely relevant across different species.

“We believe that many insights gained from our mouse studies can be translated to humans,” he remarked. “I am eager to discover any disparities that may exist between species.”

How Our Bodies Prepare for Winter

For both wild animals and hunter-gatherers, adapting to seasonal changes is vital for survival, especially during prolonged, harsh winters when food is limited.

“In nature, fluctuations in water availability, light, and temperature dramatically alter the environment each season, compelling all organisms within the food chain to adjust,” noted Levine.

“For instance, one adaptation is for plants to produce more unsaturated fats, aiding their survival in cold, which causes both herbivores and carnivores to consume and store greater amounts of unsaturated fats.”

Thus, our bodies might be biologically programmed to anticipate higher intake of unsaturated fats as daylight hours shorten.

However, because we have access to the same food options throughout the year, many individuals often disregard this natural dietary shift.

We can indulge in our favorite saturated fat-laden foods year-round, but excessive consumption in the fall or winter can mislead your body clock into thinking it’s still summer.

“In modern society, foods high in saturated fats are abundantly available,” asserted lead author Professor Louis Ptacek, a UCSF neurologist, in BBC Science Focus. “Moreover, we often eat at ‘unnatural’ times due to light conditions. Generally, adhering to a consistent circadian eating schedule during daylight is healthier.”

Levin added that consuming seasonally appropriate foods might also be advantageous, suggesting a potential shift in fat sources throughout the year. However, he stated that further research is needed to validate this strategy.

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Source: www.sciencefocus.com

Wegovy Improves Heart Health Even with Slight Weight Loss

Increasing evidence suggests that GLP-1 drugs like Wegovy offer benefits beyond treating obesity and type 2 diabetes.

Shelby Knowles/Bloomberg via Getty Images

Research indicates that the weight-loss medication Wegovy can lower the risk of heart attacks and other cardiovascular conditions, even in individuals who may not experience significant weight loss or those who aren’t severely obese.

Earlier findings from the SELECT trial hinted that Wegovy, a GLP-1 weight-loss drug, could have these heart health benefits, but it remained unclear if they were solely due to weight reduction. Studies involving pigs suggested a direct protective effect on the heart, now validated in humans.

“The important takeaway is that the cardiovascular advantages of these drugs occur independently of weight loss. This repositions them as drugs that modify diseases rather than merely aiding weight loss,” explains John Deanfield from University College London.

Wegovy contains semaglutide, a GLP-1 treatment, as well as Ozempic, which is designed for managing type 2 diabetes. While these treatments are approved for weight management and diabetes, they have shown promise in various other conditions, including dementia and alcoholism.

The SELECT trial assessed semaglutide against placebo regarding cardiovascular risks in 17,604 participants aged 45 and older who were overweight or obese. None were diabetic, yet all had some heart disease. In November 2023, Deanfield et al. announced that semaglutide reduced the likelihood of heart attacks, strokes, and other severe cardiac events by 20%.

Researchers are analyzing data to determine if these effects are solely due to weight loss, examining various body mass index (BMI) and weight loss ranges. They discovered that individuals starting with a BMI of 27—categorized as mildly obese—showed improved heart disease risk after using semaglutide, as did the severely obese with a BMI of 44.

Interestingly, the degree of weight lost seemed to have minimal impact on cardiovascular improvements, whether during the initial 20 weeks or throughout the nearly two-year study.

However, abdominal fat appears to play a significant role. Researchers noted that a slimmer waist at the study’s onset correlated with reduced heart disease risk, regardless of whether participants received semaglutide or a placebo. Moreover, after years on semaglutide, each 5-centimeter reduction in waist size was linked to a 9% decrease in cardiovascular event risk. The research team found that waistline reduction contributed to nearly one-third of the drug’s heart-protective effects, while the reasons for the other benefits remain unclear.

These results reinforce semaglutide’s potential beyond just weight management, as individuals in the placebo group even experienced a slight rise in heart disease risk while losing weight; this may be reflective of an underlying health issue, Deanfield notes.

Further studies are required to unpack how semaglutide and potentially other GLP-1 medications exert these benefits. Professor Deanfield speculates that enhancements in blood vessel function and blood pressure could be at play, alongside possible anti-inflammatory effects.

“Inflammation is a crucial mechanism influencing various diseases we want to avoid,” he mentions. “This appears to be a shared pathway targeted by these drugs.”

This advantage might also be linked to how semaglutide interacts with fat surrounding the heart, referred to as epicardial adipose tissue. Gianluca Iacobellis from the University of Miami highlights, “Semaglutide binds to epicardial adipose tissue receptors to enhance tissue health, consequently improving heart function and lowering cardiovascular event risks.”

“The query remains: What criteria should we establish to identify individuals most likely to benefit from these drugs?” questions Stefano Masi from the University of Pisa, Italy. “This is an ongoing challenge.”

topic:

  • Medical drugs /
  • heart disease

Source: www.newscientist.com

High Dosage of Wegovy: Impacts on Weight Loss and Side Effects

Weekly Wegovy Injections Facilitate Weight Loss

James Manning/PA Images/Alamy

Testing reveals that a higher weekly dosage of Wegovy is linked to an increased risk of side effects.

Prior research indicates that individuals receiving the standard weekly doses of Wegovy, which contains the active ingredient semaglutide, can lose up to 15% of their body weight over a year when combined with a healthy diet and exercise regimen. This medication mimics the action of GLP-1, a hormone akin to glucagon, which aids in numerous ways such as delaying stomach emptying and signaling the brain to suppress appetite.

Produced by the pharmaceutical company Novo Nordisk, Wegovy is approved for use among individuals with obesity or those who are overweight and possess at least one weight-related condition like type 2 diabetes. “However, some patients may not experience the desired level of weight loss or may seek more than the average 10-15% reduction,” says Lora Heisler, who was not part of the research team from the University of Aberdeen in the UK.

To explore the potential benefits of increased dosage, Shawn Wharton and colleagues, including scientists from the University of Toronto and Novo Nordisk, studied over 1,000 obese adults across 11 countries, including the United States, Canada, and parts of Europe.

Participants, all without diabetes, were randomly assigned to receive either a high dosage of 7.2 milligrams or the standard 2.4 milligrams of semaglutide, alongside a placebo injection mimicking Wegovy. Doses of semaglutide were gradually elevated over several weeks, and all participants were encouraged to maintain a caloric deficit of 500 calories per day and engage in physical activity for 150 minutes weekly.

After one year, those receiving the standard dosage lost an average of 16% of their body weight, while the high-dose group achieved about 19% weight loss. Conversely, the placebo group lost approximately 44% of their body weight.

One-third of participants in the standard dosage category experienced over 20% weight loss, compared to almost half in the high-dose group. Only 3% in the placebo group reached this threshold, indicating that higher dosages can significantly enhance weight loss outcomes, according to Heisler.

At the onset of the study, more than one-third of participants in each group had prediabetes, marked by elevated blood sugar levels without qualifying for type 2 diabetes. By the study’s conclusion, diabetes cases in the high-dose group decreased by 83%, while cases within the standard-dose group fell by 74%. “This is highly encouraging, as the main objective of weight loss is to enhance overall health,” Heisler remarks.

Nevertheless, there are noteworthy drawbacks. Bowel-related side effects, such as nausea, vomiting, and diarrhea, were reported by 61% in the standard-dose group, while 71% in the high-dose category experienced similar issues. In comparison, 40% of those taking the placebo also faced these symptoms, which might not be directly related to the treatment, according to Heisler.

Moreover, over 20% of the high-dose group reported unpleasant skin sensations known as dysesthesia. As a result, four participants discontinued their treatment. By contrast, only 6% of the standard-dose recipients and just one in the placebo group reported this side effect, with no one ceasing treatment.

These findings indicate that the advantages of higher dosages may outweigh the associated risks for certain individuals, according to Heisler. “For those requiring substantial weight loss who don’t experience many side effects, the higher dose may facilitate their goals,” she states. However, it may not be appropriate for individuals achieving sufficient weight loss on standard doses or those enduring severe side effects. She emphasizes the need for additional trials to validate these results before clinical application.

In a separate trial, Wharton and his team suggest that higher dosages might yield greater weight loss and enhanced blood glucose levels in individuals with both obesity and type 2 diabetes. However, the results were not statistically significant, indicating a need for further investigation, says Simon Cork from Anglia Ruskin University in the UK.

Topics:

  • obesity/
  • Weight loss drugs

Source: www.newscientist.com

Why Most Diets Fail According to Weight Loss Surgeons—and What to Eat for Success

Many individuals have attempted to trim their waistlines through calorie counting and frequent gym visits, yet often with little success. So, what’s the underlying issue?

According to Dr. Andrew Jenkinson, a consultant in bariatric surgery at University College London Hospital and author of Why We Eat (Too Much) and How to Eat (and Still Lose Weight), losing weight is less about the quantity of food consumed or the amount of exercise than previously thought.

He suggests that rather than obsessing over calorie counts and relentless gym sessions, a more practical approach to weight loss could be achieved by consuming foods that effectively regulate levels of the hormone leptin.

How does leptin function? What foods should fill your plate? Is there a straightforward way to combat cravings? Dr. Jenkinson addressed these topics in detail during our recent discussion.

BBC Science Focus: What is the global obesity crisis?

AJ: The Western world faces significant issues that are straining healthcare systems. In the U.S., about one-third of the population is considered morbidly obese, impacting their health drastically.

In Europe, the rate is around one-quarter. Many of these individuals face heightened risks of type 2 diabetes, hypertension, sleep apnea, joint problems, and certain cancers.



For the first time in history, life expectancy is declining due to obesity. New treatments, such as injections, are available, but they come at a hefty price.

Millions rely on them, and thus, obesity has become a major economic and health concern that requires urgent attention.

Obesity does not stem solely from the abundance of appealing, high-calorie food. These foods may act similarly to drugs, disrupting normal weight regulation mechanisms.

Wild animal populations face similar biological pathways, yet there’s no evidence that lions become inactive due to an oversupply of antelope.

Is the issue rooted in our hormones?

Yes. Leptin, often termed the ‘satiety hormone,’ is crucial in regulating the weight of wildlife and should ideally function in the same way for humans.

Leptin levels send signals to the brain’s weight control center, located in the hypothalamus. This hormone essentially dictates body weight: when leptin is detected, appetite diminishes and metabolism increases.

Leptin is produced by fat cells, meaning that higher leptin levels should correlate with reduced appetite and increased metabolism.

However, some food types can obstruct leptin signaling. While it’s well-known that sugar, refined carbohydrates, and processed foods contribute to obesity, the root cause isn’t merely their calorie content; it’s how they elevate insulin levels, which in turn inhibits leptin.

When leptin signaling fails, the brain loses track of whether we are overweight or underweight. You might look visibly overweight, but your brain might mistakenly signal that you need to eat more.

It’s akin to driving a vehicle and suddenly noticing the fuel gauge is empty. You panic and refuel, but the tank was never really empty to begin with—the gauge itself was faulty. Similarly, when leptin is blocked, your body undergoes a comparable malfunction.

What significance do calories hold for weight loss?

Calories are essential for survival, acting as energy units stored within plants. Plants predominantly store carbohydrates and energy within their cellular structures.

We utilize this energy for various bodily functions like heat generation, heartbeat, and movement. Interestingly, approximately 70% of the energy we consume is expended at rest, termed basal metabolism, which encompasses immune functions, maintaining body temperature, heart rate, and more.

There’s a common misconception among those who focus exclusively on calorie counts: the body can easily eliminate excess calories. For instance, you could adjust basal metabolism to burn an additional 600-700 calories daily through activity akin to enjoying a lavish three-course meal or engaging in a 10k run.

If you adopt a low-calorie diet, your body can also adapt to this lower intake, ultimately halting weight loss within weeks.

Moreover, while many individuals may overconsume, our bodies respond by increasing basal metabolism, leading to greater energy expenditure. This is a significant factor in the Western epidemic of hypertension, as our bodies heighten blood pressure to manage energy use.

Why do some people find it harder to lose weight than others?

This variation relates to the concept of a weight setpoint or weight anchor. Imagine it as an anchor that keeps a ship tethered to one location—similarly, your weight anchor dictates your body’s weight range.

Your weight anchor could be set within the “overweight” or “obese” zone. Even if you work hard at the gym or adhere to a low-calorie diet, your brain’s weight control center may pull you back to your setpoint.

This anchor is influenced by several factors, many of which you can change, but one is immutable: your genetics.

We all know individuals who remain naturally slim and can indulge in their favorite treats without gaining weight. However, about 25% to 33% of the population carries genes that predispose them to weight gain when exposed to Western dietary habits.

This genetic predisposition is heightened through easy access to sugar, refined carbohydrates, processed foods, fructose, vegetable oils, and more. Unfortunately, much of this unhealthy food is readily available in supermarkets, often overshadowing the fresh produce aisles.

This misunderstanding is prevalent among practitioners who advocate for calorie counting; it overlooks the fundamental principle that the type of food we consume acts on our bodies as a form of medicine.

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So, what should we be eating?

Remember, it’s about lifestyle changes rather than temporary dieting. Dieting implies short-term calorie restriction. However, if you comprehend how different foods impact your body like medications, you will naturally shed pounds. Avoid sugar, refined carbohydrates, and toxic vegetable oils that adversely affect insulin levels.

Opt for homemade meals, and without much struggle, your weight setpoints will begin to decrease. You may find you lose considerably more weight than through conventional exercise efforts. This doesn’t have to be a struggle or cause frustration.

For instance, you could effortlessly replace unhealthy snacks eaten while watching television with a plate of veggies sprinkled with a bit of salt. It is all about recognizing and transforming unhealthy habits into healthier alternatives.

Initially, giving up sugar or chocolate may trigger cravings. However, these can be managed through a technique called “Crave Surfing,” which involves acknowledging the craving without disregarding it. Focus on it, and you will find that these cravings will ebb and flow, becoming less intense over time.

What role should exercise play in weight loss?

If you can dedicate time to the gym for about an hour and a half, engaging in vigorous activities, you could potentially burn 1000 calories daily. Over six days a week, this can significantly impact your weight.

However, for most, this level of control is unattainable unless you are an athlete. Recommendations for 30 minutes of exercise, 3-4 times a week, have minimal effect on weight loss—you may only shed around 2 kilograms annually.

Just like limiting calories, exercise can enhance metabolism efficiency, causing the body to become more adept at conserving energy.

For example, if you engage in a 30-minute workout and burn about 400 calories, it may leave you feeling hungrier. Unless you maintain exceptional willpower, you are likely to consume those 400 calories back. Instead of burning these calories, your metabolism functions to regulate them.

The way to counter this effect involves a combination of calorie restriction and physical activity for optimal results. Our metabolism cannot typically adjust by more than 600 or 700 kilocalories a day. Hence, if you successfully reduce your intake beyond 1000 calories, weight loss is likely to follow—but it is a challenging task that can lead to fatigue and hunger.

This interview has been edited for clarity and brevity.


About our expert, Dr. Andrew Jenkinson

Andrew is a consultant specializing in obesity (weight loss) and general surgical procedures at University College London Hospital.

He is also the author of Why We Eat (Too Much) and How to Eat (and Still Lose Weight).

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Source: www.sciencefocus.com

Unseen Belly Fat Might Be Accelerating Your Aging Mind — Even If You’re at a Healthy Weight

Recent studies indicate that visceral fat (the concealed belly fat located deep within the abdomen) may contribute to the accelerated aging of your heart.

In contrast to subcutaneous fat, which resides just beneath the skin, visceral fat envelops vital organs like the stomach, liver, and intestines. Individuals with elevated visceral fat levels might present as slimmer or even possess a healthy body mass index (BMI) and weight.

“Staying active is crucial, but our findings reveal that this hidden fat can pose risks even for those who seem healthy,” states Professor Declan Olegan, who led the research.

Two MRI scans, showcasing more visceral fat (red) and subcutaneous fat (blue) in the left subject – Photo credit: AMRA Medical

This research has been published in European Heart Journal. Scientists at the Medical Research Council of London (MRC) Institute of Medical Sciences examined data from 21,241 participants in the UK Biobank.

Whole-body imaging was utilized to analyze fat distribution, along with an in-depth investigation of the heart and blood vessels. Artificial intelligence was implemented to estimate a “heart age” for each participant, reflecting signs of organ aging, such as hardened or inflamed tissue.

The study identified notable differences between genders. Men are prone to accumulating visceral fat in the abdomen, often resulting in expedited heart aging.

Conversely, women have a genetic tendency to store fat around the waist and thighs, resulting in a “pear shape,” which may decelerate heart aging. Elevated estrogen levels in premenopausal women are linked to reduced heart aging, indicating that hormones might play a significant role in organ protection.

Blood analyses revealed a correlation between visceral fat and increased inflammation, suggesting another factor that could contribute to premature aging.

Utilizing whole-body MRI scans to analyze fat distribution and examine the heart in detail (credit: MRC Laboratory of Medical Sciences)

Professor Brian Williams, Chief Science Officer and Medical Officer at the British Heart Foundation, stated: “We are already aware that excess visceral fat around the heart and liver can result in increased blood pressure and high cholesterol, which may further accelerate heart and blood vessel aging.”

“The typical pattern of fat distribution observed in women is influenced by estrogen, suggesting that hormones could be pivotal in developing future treatments for cardiac aging.

“Adopting healthier eating habits and increasing physical activity can aid in lowering visceral fat levels.”

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Source: www.sciencefocus.com

Could Cultivating Food on Strings with Fat-Confined Microbeads Aid Weight Loss?

Edible microbeads can absorb fat in the intestines

Vacharapong Wongsalab/Getty Images

Researchers are developing edible microbeads that can absorb fat, aiding weight loss. These beads may one day be introduced into foods and beverages to help manage or prevent obesity.

Despite ongoing efforts to address obesity, global rates continue to rise. While new weight loss medications like Wegovy and Zepbound have emerged, their high cost and potential side effects highlight the need for alternative solutions.

In this context, Yuu and her team from Sichuan University in China have crafted edible microbeads that capture fat before it’s absorbed by the body. These beads are composed of vitamin E and green tea compounds, coated with alginate, a seaweed-derived fiber. All components are food-safe and approved by the US FDA.

When these beads are ingested, the alginate layer expands in the stomach, allowing partially digested fats in the intestines to enter the beads and bind with their compounds. The beads, along with the captured fat, are then expelled during defecation.

In experiments, rats on a 60% fat diet consuming the microbeads lost an average of 17% of their body weight after 30 days. In contrast, a comparable group fed the same high-fat diet without beads showed no weight loss, and another group on a reduced-fat diet also did not lose weight. The microbeads-treated rats exhibited less fatty tissue and reduced liver damage.

Further analysis of the feces from rats given microbeads revealed fat content comparable to that of the group treated with Orlistat, a weight loss drug that blocks fat absorption. This suggests that the microbeads effectively inhibit visceral fat uptake without the gastrointestinal side effects associated with Orlistat.

“One reason [Orlistat] hasn’t gained much popularity is due to the difficulty in managing bowel movements,” notes Thunder Kirsten from Cornell University. Thus, these edible microbeads may present a viable alternative to pharmaceutical therapies, although human trials are still necessary.

A clinical trial with 26 participants is already in progress. “We anticipate preliminary results within the next year,” Wu remarked during a press release at the American Chemical Society Conference on August 21.

One concern raised is that these microbeads may interfere with the absorption of essential fat-soluble vitamins. Additionally, it’s unclear how palatable they will be to consumers. Similar strategies using synthetic indigestible fats called olestra were attempted in the late 1990s and early 2000s but failed to gain traction due to poor sales, leading to their withdrawal about a decade ago.

Researchers aim to create virtually flavorless beads that can be shaped like tapioca or boba, making them suitable for desserts and bubble tea. “We want to design something that fits seamlessly into people’s eating habits and lifestyles,” Wu stated.

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Source: www.newscientist.com

Achieve Double the Weight Loss with a Minimally Processed Diet

Items like cereal bars and protein bars can be either homemade or bought, potentially containing ultra-processed components.

Drong/Shutterstock

Following a super processed homemade diet may result in losing double the weight compared to an ultra-processed diet or snack.

Foods are generally classified as highly processed when they contain ingredients that aren’t typically found in home cooking, such as high fructose corn syrup or additives designed to enhance flavor and appearance, like flavorings and stabilizers.

Numerous studies have associated the consumption of ultra-processed foods with negative health impacts, including cardiovascular issues, type 2 diabetes, and weight gain. These studies have consistently noted that ultra-processed foods often contain high levels of sugar, salt, and fat, found in snacks like cookies and microwave dinners, raising questions about whether it’s just the ingredients that make them unhealthy, or if there’s something inherently harmful about the processing itself.

To explore this in relation to weight loss, Samuel Dicken and his colleagues at University College London conducted randomized trials where participants consumed either an ultra-processed or minimally processed diet. The study involved 55 overweight or obese individuals randomly assigned to one of the two diets.

“People often picture pizza and chips, but the researchers indicate that both diets align with the UK Eatwell Guide, which emphasizes a protein-rich diet including beans, fish, eggs, and meat, and encourages intake of at least five portions of fruits and vegetables. Both diets were matched to have similar levels of fat, sugar, salt, and carbohydrates,” Dicken explains.

Meals were provided to participants, marking the first study to compare such diets in a real-world setting rather than in controlled environments like hospitals or laboratories. The ultra-processed group consumed foods with lower fat and salt content, including breakfast cereals, protein bars, chicken sandwiches, and frozen lasagna, which are typically marketed with “healthy” nutritional claims in supermarkets,” Dicken notes.

The minimally processed group enjoyed homemade foods like overnight oats, chicken salad, homemade bread, and spaghetti bolognese. Both groups were given ample food, approximately 4000 calories per day, and instructed to eat to their satisfaction. Participants followed one diet for eight weeks, switched to the other after a four-week break, and alternated between both.

While the study aimed to examine the health impacts of balanced diets made in various ways rather than to focus solely on weight loss, both diets led to reductions in weight. The minimally processed food group lost 2% of their weight, while the ultra-processed group saw a 1% decrease.

“We observed greater weight loss with minimally processed diets, along with more significant fat reduction and lowered cravings,” Dicken says.

The research team also investigated other health metrics and discovered that the minimally processed diets decreased body fat volume and blood lipid levels. Interestingly, the ultra-processed diet was linked to lower levels of low-density lipoprotein (LDL), known as “bad” cholesterol.

However, Ciarán Forde from Wageningen University in the Netherlands points out that ultra-processed meals tend to be more calorie-dense than their minimally processed counterparts. “Fundamental questions remain regarding which types of processing or ingredients contribute to the effects observed,” he adds.

Forde suggests that it is unsurprising participants lost weight considering their starting point of being overweight and obese while transitioning to healthier diets. This may indicate that the weight loss results are not applicable to the general population.

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Source: www.newscientist.com

Achieve Weight Loss with a Highly Processed Food Diet

Cereal bars and protein bars can either be store-bought or homemade, often containing ultra-processed components.

Drong/Shutterstock

Research suggests that while it’s possible to shed weight consuming highly processed foods, the results may not be as significant as when they are eliminated from the diet.

Foods are categorized as extremely processed when they include ingredients such as high fructose corn syrup or additives meant to enhance flavor and presentation, such as flavoring agents and preservatives.

Numerous studies have connected the consumption of ultra-processed foods to adverse health effects, including cardiovascular issues, type 2 diabetes, and weight gain. However, it’s debated whether the unhealthy aspect is solely due to certain ingredients or if the processing itself is inherently damaging.

To explore this in relation to weight loss, Samuel Dicken from University College London and his team conducted randomized trials, assigning 55 overweight or obese individuals to either an ultra-processed or minimally processed diet.

“People often think of pizza and chips, yet the study incorporated meals from the UK Eatwell Guide, featuring protein sources like beans, fish, and meat, while encouraging a balanced diet with at least five portions of fruits and vegetables. The meals were matched in terms of fats, sugars, salt, and carbohydrates,” explained Dicken.

Participants received the meals, marking the first study to assess these diets under real-world conditions instead of clinical environments. The ultra-processed options included lower-fat and lower-salt items like breakfast cereals, protein bars, chicken sandwiches, and ready-made lasagna. “These are the types of foods that carry health claims in supermarkets,” says Dicken.

Meanwhile, the minimally processed meals encompassed homemade options such as overnight oats, chicken salad, freshly baked bread, and spaghetti bolognese. Both groups were provided around 4,000 calories daily, with the instruction to eat to their satisfaction. Participants switched between the diets after eight weeks, taking a four-week break before transitioning again.

Although the study’s primary aim focused on the health effects of balanced diets prepared in various ways rather than directly targeting weight loss, both diets resulted in weight reductions. The minimally processed diet led to a 2% weight loss, while those on the ultra-processed diet saw a 1% decrease.

“We observed greater weight loss from the minimally processed diets, as well as increased fat loss and a notable reduction in cravings,” stated Dicken.

Further evaluations revealed that minimally processed diets contributed to lower body fat volumes and improved blood markers. Interestingly, participants on the ultra-processed diet exhibited decreased levels of low-density lipoprotein (LDL), known as “bad” cholesterol.

However, Ciarán Forde from Wageningen University in the Netherlands pointed out that ultra-processed meals are typically more calorie-dense compared to minimally processed alternatives. “Fundamental questions remain regarding which specific treatments or ingredients drive the observed outcomes,” he noted.

Forde also emphasized that the weight loss observed might not be applicable to the general population since participants started as overweight or obese and transitioned to healthier eating habits.

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Source: www.newscientist.com

Why Food Noise, Not Willpower, Holds the Secret to Weight Loss

Among the countless enigmas of science, I find myself intrigued by the enticing toffee tucked away in the kitchen cupboard. It has me completely captivated—almost like I’m being swept into some metaphysical currents.

The pressing question is: how? How do chocolate bars diminish my willpower when I thought I was a seasoned adult who should know better?

The solution may be linked to the concept of “food noise.” This pervasive and disruptive phenomenon relates to the relationship between food and our perceptions of it.

In the case of my beloved toffee crunch, these fleeting thoughts are mere distractions that I inevitably give in to within an hour.

Food noise can be a serious issue

For some individuals, food noise is a substantial concern. Hayashi Daimon, a doctoral researcher at Penn State University, explains.

He notes that when the volume increases, food noise becomes a source of “a constant obsession that undermines an individual’s well-being and complicates healthy choices.”

Although research on food noise is sparse, in 2023, Hayashi and his colleagues published a paper aiming to connect established knowledge about food cues and anecdotal insights into food noise. Their team is actively pursuing further research.

“I believe that research on food noise is at a point where asking the right questions and seeking empirical data is more crucial than making presumptions,” Yayashi highlights.

“From our preliminary findings, I can tell you that most social media accounts describe food noise as a source of distress, with people indicating they would rather avoid it.”

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Individuals respond variably to food cues

Hayashi asserts that food noise is characterized by an ongoing, heightened reaction to food signals—ranging from social media advertisements to the aroma of someone’s dish, and the internal mechanisms that regulate appetite hormones.

While these cues serve to nourish us, some individuals exhibit quicker responses.

“A combination of personal attributes such as genetics, lifestyle, and stress can lead to heightened sensitivity to food noise, particularly as we are frequently subjected to strong external food signals.”

An intriguing study has emerged from research on GLP-1 agonists, a category of weight loss medications including Ozempic.

“Anécdotal evidence suggests that many individuals use the term ‘food noise’ to describe obsessive behaviors regarding food prior to starting such treatments,” says Hayashi.

“My hypothesis is that one of the impacts of these medications, which might clarify their efficacy in obesity treatment, is that they diminish the responsiveness to food cues and lessen susceptibility to food noise.”

Further research will address this inquiry and determine the extent of food noise’s impact on others.

Certain foods are rich in brain dopamine reactions termed “Bliss Points,” particularly those high in sugar, fat, and salt, like chocolate digestives – Credit: Peter Dazelly via Getty

What actions can we take regarding food noise now?

If you’re searching for approaches to manage intrusive thoughts about food (or intense cravings for forbidden toffee), Hayashi suggests consulting a nutritionist. They can assist in examining your dietary habits and devising strategies to enhance resistance to food cues.

These strategies may encompass mindful eating practices or ensuring sufficient meal consumption to avoid the discomfort of hunger at mealtimes.

Crucially, avoid falling into the trap of guilt surrounding the notion that struggling with food represents personal failure.

“We exist in a paradoxical society where cultural messages incessantly promote thinness and muscularity, while simultaneously compelling us to engage with external food cues that lead to poor dietary choices,” he explains.

“This creates an ideal scenario for suffering from food noise, compounded by a social structure that makes access to healthier options more challenging than opting for convenient, highly processed foods lacking in nutritional value.”

About our experts

Hayashi Daimon is a doctoral researcher at Penn State University in the United States. His work has been featured in Nutrients, Journal of Human Nutrition and Dietetics, and Surgery for Obesity and Related Diseases.

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Source: www.sciencefocus.com

You Can Lose Weight Without Regularly Using Medications Like Ozempic

Ozempic and other GLP-1 medications might not need as frequent dosing as currently prescribed

Associated Press/Alamy

Individuals using GLP-1 medications such as Ozempic can still achieve weight loss despite facing difficulties in obtaining their prescriptions.

Medications like Semaglutide, marketed under the names Ozempic and Wegovy, have transformed obesity treatment, yet the increasing demand has led to significant supply shortages. In the U.S., changes in insurance coverage for these drugs can lead to confusion. For instance, CVS Caremark, which assists insurers in managing their prescription plans, recently discontinued coverage for Eli Lilly’s Zepbound, linked to the GLP-1 drug tilzepatide.

To investigate the impact of this confusion, Kaelen Medeiros and a colleague from a New York firm analyzed data from over 6,000 participants in the U.S. who enrolled in their program for a year between 2021 and 2024.

The program provided access to an app delivering bi-weekly lessons aimed at optimizing lifestyle choices such as nutrition and physical activity. Additionally, participants enjoyed regular one-on-one consultations with a health coach who assisted in applying these lessons. For an extra charge, all participants received GLP-1 medications, like Ozempic, mainly on a weekly basis.

By the program’s conclusion, 73% of participants experienced at least one disruption in GLP-1 access, defined as missing the medication for a minimum of 13 weeks. These participants received, on average, eight months’ supply of GLP-1 over the year-long trial. Participants lost an average of 14% of their body weight, compared to a 17% reduction among those who did not face such disruptions. The findings were shared at the Endocrinology Society’s annual general meeting in San Francisco on July 14th.

A similar rate of weight loss was observed in the program’s second year, regardless of the consistency of GLP-1 supply. “Although this confusion is concerning, it’s encouraging to see significant clinically relevant weight loss achieved despite it,” Medeiros remarks.

“This study is promising,” says Priya Jaisinghani from NYU Langone Health, New York. However, further research is needed to assess how the health coaching and lifestyle lessons provided to participants influenced weight loss, she notes. The researchers didn’t measure the engagement levels of participants in this segment of the program. Medeiros pointed out that variations in adherence might have impacted the outcomes.

Some participants also took metformin, a medication for type 2 diabetes that can aid in weight loss. Nevertheless, metformin is associated with only about a 2% reduction in body weight.

Topics:

  • Medical drugs /
  • Weight loss

Source: www.newscientist.com

Zero-Calorie Foods Won’t Aid Your Weight Loss Journey

The concept of negative or zero-calorie foods, while popular on diet platforms, remains a topic of debate. The premise suggests that our bodies expend as much energy, if not more, digesting certain fruits and vegetables than the energy they provide.

However, there is no scientific backing for this notion. Even the foods lowest in calories, like celery and watercress, contain essential energy for their digestion.

In 2019, a researcher at the University of Alabama conducted a study involving celery and a bearded dragon. You can read the study here. Although the choice of a reptile may seem peculiar, bearded dragons have an omnivorous diet and a digestive process akin to humans.

The large lizard consumed 5% of its body weight in celery. Researchers monitored metabolic rates, gathered fecal and urinary samples, and assessed energy expelled through excretion.

The findings revealed that lizards only utilized about three-quarters of the energy provided by celery, which challenges the idea of negative calorie foods.

Nonetheless, some nutrition experts contend that emphasizing calorie count is not the best strategy for weight management, as the body employs different biological processes for digesting various food types.

For example, our bodies expend considerably more energy breaking down proteins compared to fats and carbohydrates, which are more easily accessible for energy. Thus, the type of food is more crucial than merely the calorie content.

Ultra-processed foods are often high in fats and carbohydrates, offering quick satisfaction but packing a lot of energy, much of which gets stored in fat cells.

In contrast, whole foods, particularly those rich in protein and fiber, generally require more energy for digestion than their processed counterparts.

Fruits and vegetables, often branded as negative or zero-calorie foods, are vital components of a balanced diet.

However, relying solely on these could deprive you of essential nutrients and lead to significant hunger and frustration.


This article addresses the inquiry (from Dani Sherman via email) regarding “Are Negative Calorie Foods Real?”

Feel free to email us your questions at Question@sciencefocus.com or message us on Facebook, Twitter, or Instagram (please include your name and location).

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Four Foods That Enhance Ozempic Weight Loss (and Ones That Hinder It)

There are no specific foods that are prohibited while using Ozempic (semaglutide), which is prescribed for managing type 2 diabetes and may assist in weight loss.

However, the following recommendations can help maximize your weight loss efforts and promote a sustainable, healthy diet over time.

Foods to Increase…

1. High-fiber foods

Fiber slows the digestion process and enhances the effectiveness of Ozempic in emptying the stomach, helping you feel full longer and preventing blood sugar spikes.

Examples of high-fiber foods include vegetables (like leafy greens, carrots, broccoli, etc.), fruits (such as apples, berries, oranges, etc.), and whole grains like oats.

High-fiber options like oats and fruits can slow sugar release and support gut health – Credit: Zeljkosantrac

2. Lean protein

Incorporating lean proteins such as chicken, fish, and plant-based proteins helps stabilize blood sugar levels.

3. Healthy fats

Sources of healthy fats like avocados, nuts, seeds, and olive oil provide sustained energy and assist in blood sugar regulation without causing spikes.

4. Low-glycemic foods

Foods with a low glycemic index, such as sweet potatoes and non-starchy vegetables, can help prevent rapid increases in blood glucose levels.

Processed and fried foods may exacerbate the side effects of semaglutide, including nausea – Credit: Alexander Spatari via Getty

Foods to Reduce…

1. Sugary treats

Candies, pastries, sodas, and other sweet snacks can cause spikes in blood sugar and contribute to nausea and other digestive issues.

2. Processed and Fried Foods

These foods are typically high in unhealthy fats, salts, and preservatives, which can worsen nausea and interfere with blood sugar control.

3. Spicy Foods

Due to the delayed gastric emptying caused by Ozempic, spicy or heavy foods may lead to nausea or gastrointestinal discomfort.

4. Alcohol

Individuals taking Ozempic may experience reduced alcohol tolerance, so it’s wise to be mindful of consumption. Additionally, alcohol contains calories that won’t aid in weight loss.


This article addresses the question posed by Jamil Pierce from Surrey: “What are the best and worst foods to eat while on Ozempic?”

Please reach out to submit your questions to Question @sciencefocus.com or message us via Facebook, Twitter, or Instagram (please include your name and location).

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Study Reveals Potential Weight Gain from Certain ‘Healthy Fats’

Recent studies indicate that the fats found in olive oil may contribute to weight gain more significantly than fats from other sources.

A recent report revealed that oleic acid, the primary fatty component in olive oil, can stimulate the formation of new fat cells.

Oleic acid is a type of monosaturated fat, often referred to as omega-9. While olive oil is the main source of oleic acid, this fatty acid is also present in other oils, such as canola and sunflower oil.

“You can think of fat cells as the army,” stated the study’s co-author, Dr. Michael Rudolph, Assistant Professor of Biochemistry and Physiology at the University of Oklahoma. “Dried oleic acid initially boosts the number of ‘fat cell soldiers’ in the army, enhancing the capacity to store surplus dietary nutrients.”

“If excess nutrients surpass the number of fat cells over time, it can lead to obesity, and if left unaddressed, may result in cardiovascular disease or diabetes.”

Olive oil is a key component of the Mediterranean diet and is renowned for promoting longevity, healthy aging, as well as optimal brain, heart, and metabolic health – Credit: Elena Noviero via Getty

Researchers from the University of Oklahoma, Yale University, and New York conducted a study where mice were fed a variety of high-fat diets that included coconut oil, peanut oil, milk, lard, and soy oils.

They found that elevated levels of oleic acid influenced the activity of two proteins, AKT2 and LXR, leading to an accelerated growth of progenitor cells that develop into new adipocytes. This effect was not observed with other types of fats.

Nevertheless, Dr. Rudolph emphasized that completely eliminating olive oil is not the answer.

“The key takeaway is moderation and diversifying fat sources,” he advised. “While a balanced intake of oleic acid can be beneficial, excessive and prolonged consumption may pose risks. For individuals at risk for heart disease, high oleic acid levels could be unfavorable.”

In moderation, oleic acid is linked with numerous health benefits. Previous studies have shown that olive oil consumption is associated with longer lifespans, healthy aging, reduced inflammation, and a decreased risk of obesity and heart disease.

It’s important to note that since this study was conducted exclusively on mice, its findings may not directly apply to humans.

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Source: www.sciencefocus.com

What Rodents Teach Us About Weight Loss and Hunger

Do we truly possess free will in our dietary choices? This perplexing question lies at the core of why so many struggle to adhere to their diets.

To explore this, neuroscientist Harvey J. Grill from the University of Pennsylvania turned to rats, investigating what would occur if all brains except the brainstem were removed. The brainstem regulates essential functions like heart rate and breathing, yet these animals lost their ability to smell, see, and remember.

Did they burn enough calories?

To assess this, Dr. Grill administered liquid food directly into their mouths.

“Once they reached a certain point, they allowed the food to flow out,” he explained.

Beginning decades ago, these studies laid the groundwork for ongoing research that continuously astonished scientists, challenging the notion that perfect animals are linked to consciousness. This is particularly relevant considering the GLP-1 drugs, such as Ozempic, which complicate our understanding of how weight-loss medications impact the brain’s feeding control system.

Emerging narratives do not clarify why some individuals become obese while others do not. Rather, they hint at when we begin eating and when we cease.

Obesity researcher Dr. Jeffrey Friedman from Rockefeller University in New York noted that although most studies involve rodents, it is a misconception to assume that humans are fundamentally different. We are shaped by billions of years of evolution, he stated.

As researchers delved into dietary control, they discovered that the brain receives consistent signals indicating that the body is adequately supplied with food. The body requires a specific calorie intake, and these signals ensure that it is fulfilled.

This process initiates even before an animal consumes its first bite. Light exposure from potential food prompts predictions regarding the caloric density of what is being offered. Neurons react more vigorously to high-calorie foods like peanut butter than to low-calorie options such as mouse chow.

Key control points emerge when an animal tastes food, as neurons recalculate calorie density based on signals transmitted from the mouth to the brainstem.

Ultimately, as food enters the intestines, a new wave of signals reaches the brain, allowing neurons to reassess the calorie content.

Zachary Knight, a neuroscientist at the University of California, San Francisco, found that the gut’s evaluation revolves around calorie content.

He observed this phenomenon when three distinct foods were injected directly into a mouse’s stomach—one being fatty food, another carbohydrate, and the third protein—each infusion containing the same caloric value.

In all cases, the brain received a uniform message regarding calorie levels, indicating that neurons registered energy in calorie terms rather than by food source.

When the brain concludes that sufficient calories have been consumed, neurons relay signals to halt feeding.

Dr. Knight expressed his surprise at these findings, having previously believed that satiety signals emanated from a “gut-brain communication” process, reflecting fullness and a conscious decision to stop eating.

Based on this understanding, some diets suggest drinking a large glass of water before meals or focusing on low-calorie foods like celery.

Nonetheless, these strategies often fail for many since they don’t address how the brain governs dietary habits. Dr. Knight found that mice do not send satiety signals to the brain; they only receive water.

It remains true that individuals can choose to eat even when satiated or refrain from eating while trying to lose weight. Dr. Grill noted exerting control not only on the brainstem but also on other areas of the brain.

However, Dr. Friedman ultimately suggested that brain control often overrides a person’s conscious choice regarding their feelings of hunger or fullness. He likened this to holding one’s breath—possible, but only for a limited duration—or suppressing a cough until unavoidable.

Scott Sternson, a neuroscientist at the University of California, San Diego, echoed this sentiment.

“We’re eager to help people initiate change,” said Dr. Sternson, co-founder of Penguin Bio, a startup focused on developing obesity treatments. While individuals can choose whether or not to eat in given moments, maintaining that control demands considerable mental resources.

“Ultimately, other things often overshadow these conscious decisions,” he remarked.

Researchers continuously uncover surprising insights into the brain’s dietary control system.

They gained knowledge about the brain’s rapid reactions to food stimuli, for instance.

Neuroscientists unearthed thousands of neurons within the hypothalamus of mice that respond to hunger. Yet how are these neurons regulated? Previous work confirmed that fasting activated these hunger neurons while neuronal activity was diminished post-feeding.

Their hypothesis posited that neurons reacted to existing fat storage in the body. For instance, low fat storage, as seen during fasting—accompanied by decreased leptin levels, a hormone released from fat—would activate hunger neurons. The assumption was that fat replenishment during eating would raise leptin levels and quiet neuronal activity.

The entire system was expected to respond gradually based on the body’s energy reserves.

However, three research groups, led by Dr. Knight, Dr. Sternson, and Mark Anderman of Beth Israel Deaconess Medical Center, investigated the immediate activity of hunger neurons.

Starting with hungry mice, they noted rapid firing of hunger neurons, signaling a need for food.

Surprisingly, when food was presented, those neurons ceased activation.

“Even before the first bite, those neurons powered down,” Dr. Knight observed. “Neurons were forecasting. Mice anticipate how many calories they would consume.”

The more calorie-dense the food presented, the more neurons silenced.

“All three laboratories were astonished,” recalled Dr. Bradford B. Lowell, who collaborated with Andermann at Beth Israel Deaconess. “It was remarkably unexpected.”

Dr. Lowell then investigated the outcome of intentionally deactivating hunger neurons, even when mice had limited food access. This was done using genetic modifications that allow for neuron activation and deactivation via drugs or blue light.

The mice refrained from eating for hours, despite the food present.

Dr. Lowell and Dr. Sternson independently executed opposite studies, activating neurons in mice post-meal, akin to a Thanksgiving feast. The animals were relaxed and satisfied.

However, Dr. Andermann, who replicated the experiment, noted “mice would rise and consume an additional 10-15% of their body weight” when their hunger neurons were activated, emphasizing that “these neurons compel focus on food.”

Researchers continue to be amazed by their findings. The complexities of brain control ensure meticulous regulation of dietary intake, leading to insights for developing new diet-controlling medications.

One notable discovery was made by Amber Aradeff, a neuroscientist at the Monell Chemical Senses Center and the University of Pennsylvania. She recently identified two distinct groups of neurons in the brainstem that respond to GLP-1 obesity medications.

One neuronal group indicated satiety, while the other triggered nausea in the rodents. Current obesity treatments target both neuronal groups, she notes. She proposes that drug development could focus on activating satiety neurons rather than those inducing nausea.

Columbia University’s Alexander Nectow made another surprising finding, identifying a distinct group of neurons in the brainstem that regulate meal volume based on bite size. “I am unsure how this functions,” he stated.

“I have spent over ten years studying this area of the brain,” Dr. Nectow shared.

He is currently exploring whether these neurons could become targets for a new class of weight loss drugs that may involve GLP-1.

“This is truly remarkable,” Dr. Nectow concluded.

Source: www.nytimes.com

New study suggests simple diet hacks are more effective than intermittent fasting for weight loss

A bowl of warm pasta, a fluffy white bread roll, or a bag of generously salted chips – these starchy delights are like dreams. No wonder many of us couldn’t imagine giving up carbs forever.

But according to Research by the University of Surrey, spending just one day without carbohydrates has a similar effect on the body as intermittent fasting.

Intermittent fasting, also known as time-limited feeding, involves alternating normal feeding periods with significantly reduced calorie intake periods. These fasting windows can be scheduled at specific times each day or throughout the week.

While this approach has various health benefits, consuming less than 800 calories a day, as recommended on the popular 5:2 diet, can be challenging for some individuals.

However, this new study suggests that reducing calories significantly on fasting days may not be necessary. Simply cutting out carbohydrates can provide similar fat-burning benefits.

“What we’re interested in is not necessarily weight loss, but the metabolic effect of this dietary intervention,” said Dr. Adam Collins, the study co-author and an associate professor of nutrition at the University of Surrey, in an interview with BBC Science Focus.

The study, which aimed to investigate the effects of carbohydrates on metabolic health, involved 12 overweight or obese adults aged 20 to 65.

Participants followed three different meal plans with five-day breaks between each diet day for 36 hours (one day and two nights of sleep). The meal plans included a normal meal, a low-carb diet with the same calorie intake as a regular diet, and a low-carb diet with reduced calories.

Results showed that consuming a low-carb diet, regardless of calorie intake, encouraged the body to burn fat for energy similar to a fasting diet.

Carbohydrates include starches such as potatoes and pasta, grains such as rice and oats, baked goods such as bread and pastries, fiber foods such as vegetables and fruits, and sugar confectionery such as sweets and chocolate.

Dr. Collins explained that the body is designed to use carbohydrates for energy after meals and fats between meals and overnight. Consuming carbs too frequently can lead to poor management of metabolism.

Intermittent fasting or reducing carbohydrate intake helps the body reset and start burning fat for energy. Dr. Collins also emphasized that while restricting carbs long-term may hinder glucose processing, alternating low-carb days with regular meal days can be a sustainable and beneficial approach for metabolic health.

He concluded by saying, “Food is not a sin. Carbs aren’t bad. Fats aren’t bad. It’s all about moderation.”

Read more:

About our experts:

Dr. Adam Collins: An associate professor of nutrition at the University of Surrey’s School of Biological Sciences. With over 20 years of experience as a qualified nutritionist, he leads BSC and MSC nutrition programs at Sally. His current research focuses on exercise intensity, energy balance, intermittent fasting, dietary timing and composition, and carbohydrate manipulation for metabolic health.

Source: www.sciencefocus.com

Physicists at Catlin determine the maximum weight of neutrinos

Physicists of the Karlsrue Tritium Neutrino (Catlin) experiment have reported so far the most accurate measurement of the upper mass limit of neutrinos, establishing it as 0.45 electron volts (EV), less than a millionth of the electron mass.



Interior view of the main spectrometer of catrin. Image credit: M. Zacher/Katrin Collaboration.

Neutrinos are the most abundant particles in the universe and exist as three different types or flavors: Electron Neutrino, Muon Neutrino, and Tau Neutrino.

These flavors vibrate. In other words, a single neutron can be converted to each type when it moves, providing compelling evidence that neutrinos have masses that contradict the original assumptions of massless neutrinos in the standard model.

But their exact mass remains one of the great mysteries of particle physics.

in New paper In the journal Sciencethe physicists from the Catlin collaboration present the results of the first five measurement campaigns of the Catlin experiment.

“The catrin experiment determines the mass of neutrinos by analyzing the beta decay of tritium,” they explained.

“During this decay, the neutrons are converted into protons, releasing both electron and electron antioxidant, the latter being neutrino antiparticles.”

“We can infer the mass of neutrinos by analyzing the distribution of total disintegration energy between the emitted electrons and the electron antioxidants.”

For 259 days between 2019 and 2021, Catlin physicists measured approximately 36 million electrons of energy. This is a dataset of 6 times the previous run.

The findings establish the strictest laboratory base upper limit for effective electron neutrino masses and place them below 0.45 eV at a 90% confidence level.

This result shows a third improvement in the mass limit of neutrinos, and doubles the previous limit.

“For this result, we analyzed five measurement campaigns. The total data collection from 2019 to 2021 is about a quarter of the total data expected from Catlin,” said Dr. Catlin Valerius, one of the two co-spokemens for the Catlin experiment and a physicist at the Karl-Thru Institute.

“In each campaign, we gained new insights and further optimized the experimental conditions,” said Dr. Suzanne Mertens, a physicist at the Max Planck Institute for Nuclear Physics and the Institute of Technology Munich.

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Max Aker et al. (Catlin collaboration). 2025. Direct neutrino mass measurements based on 259 days of catrin data. Science 388 (6743): 180-185; doi: 10.1126/science.adq9592

Source: www.sci.news

Rising Weight: Climate Change Muffles Storms and Rainfall

The heavy storm system that floods the central and southeastern US with heavy rain and winds fits a wider pattern as rainfall has increased over the eastern US half has increased in recent decades.

Data from the National Maritime and Atmospheric Administration from 1991 to 2020 show that on average the eastern part of the country received more rain, on average, than in the 20th century. At the same time, precipitation decreased in the west.

The sharp East-West division is consistent with predictions from climate scientists who expect wet areas to be wet, with dry areas becoming dry as the world warms.

Without further analysis, individual storms cannot be linked to climate change, but warming the air will result in greater rainfall. This is because warm air has the ability to retain more moisture than cooler air, and has the potential to be fueled due to overall average precipitation, and more intense storms.

The world’s temperatures are increasing year by year, driven by the combustion of fossil fuels that send greenhouse gases that warm the planets into the atmosphere. According to a recent report, the 10 people have been the hottest recordkeeping for nearly 200 years. World Weather Organization.

“When there are these very heavy rain events, trends refer to the heavy trends of these intense events,” said Deanna, an associate professor of climate and atmospheric sciences at the University of Illinois, Urbana-Champaign University.

Severe flooding could be an indirect effect of warming air and increased moisture, according to Gerald Brotzge, a Kentucky national climate scientist and director of the Kentucky Climate Center. If conditions stall a storm system, it can cause heavy rain in the same area, increasing the risk of flooding.

This is what happened when the storm recently stagnated in the region. “I think it’s a once-at-a-time event based on the amount and area covered,” Brotzge said.

Mark Jarvis, a meteorologist at the National Weather Service office in Louisville, Kentucky, described the storm as two. It brought tornadoes, strong winds and hail to the front end, then stalled and dropped historic amounts of rainfall. Western Kentucky, who saw some of the most serious effects of the storm, “it was in the eyes of the bull,” he said.

Heavy rain and flooding are common in Ohio Valley in late winter and early spring, but the system is as common as it is “very rare” for rain. “That’s what you normally see in hurricanes and tropical systems,” he said..

Storm damage is constantly happening, but the possibility that climate change is increasing them is Observed weather trendstherefore Mr.

She said that even in the western half of the United States, which is generally dry, the coming precipitation tends to drop at more extreme levels.

She called it “very eye-opening,” adding, “it’s not particularly comfortable to think we have more of this.”

Source: www.nytimes.com

Scientists suggest that this three-day diet is a crucial weight loss strategy

Dieting can become monotonous over time. While counting calories for a week or two may be manageable, doing it daily for months on end can be unbearable.

If you can relate to this struggle, a recent study conducted at the New Year’s trial might offer some relief. The research discovered that certain forms of intermittent fasting led to slightly more weight loss compared to traditional daily calorie counting.

Published in Internal Medicine Chronicles, the study compared two dietary approaches among 165 overweight or obese adults.

One group followed a 4:3 intermittent fasting plan (eating normally for four days, restricting intake for three days), while the other group reduced daily calorie consumption.

Calorie counting can result in deficits from weight loss, but the body’s metabolism is not an exact calculator, and individual responses to the same calorie intake can vary widely – Photo Credit: Getty

Both groups received exercise support and behavioral coaching, including food diaries, personalized feedback, and gym memberships.

After 12 months, participants in the fasting program lost an average of 7.6% of their body weight, compared to 5% in the daily calorie restriction group.

They also exhibited slightly positive changes in blood pressure, cholesterol levels, and fasting glucose levels.

4:3 What is intermittent fasting?

Intermittent fasting (IMF) focuses on significantly reducing food intake on a few days a week, unlike time-restricted eating (TRE), which involves eating within a daily window (e.g., 10 am to 6 pm).

In the 4:3 IMF plan, participants chose three non-consecutive “fast” days (e.g., Monday, Wednesday, Friday) during which they consumed only 20% of their usual calorie intake, amounting to approximately 400-600 kcal for women and 500-700 kcal for men. The remaining four days emphasized healthy food choices, but participants were free to eat as normal.

“Counting calories can be mentally taxing,” said Professor Daniel Ostendorf, a co-author of the study, to BBC Science Focus. “Limiting it to three days a week may have made it easier to follow over time.”

A 4:3 fasting approach can promote a decrease in calorie intake without conscious effort and show weight loss benefits.

Despite both groups having the same overall calorie target for the week, the fasting group achieved slightly greater weight loss. However, this study suggests that 4:3 intermittent fasting could be a promising option but is not a cure-all.

“The key finding of this study was that the 4:3 approach resulted in more weight loss than traditional calorie restriction,” commented Dr. Adam Collins, a nutrition scientist at the University of Surrey not involved in the research.

Collins pointed out that some unmeasured factors could impact calorie intake, emphasizing the potential benefits of intermittent energy restriction over daily calorie restriction.

Should you give it a try? According to Ostendorf and lead researcher Professor Victoria Catenacci, they advise choosing a dietary strategy that feels sustainable in the long term for weight loss goals.

“Our study suggests that 4:3 IMF can be a viable option based on additional evidence,” they concluded.

About our experts

Daniel Ostendorf is an assistant professor at the University of Tennessee, Knoxville, specializing in designing lifestyle intervention programs for adults. His research has been published in journals such as Nutrients and American Journal of Public Health.

Victoria Catenacci, MD is an associate professor at the Anschutz Medical Campus, Colorado, focusing on endocrinology, metabolism, and diabetes. Her research has been showcased in journals like Nature reviews endocrinology and Physiology and behavior.

Read more:

Source: www.sciencefocus.com

Scientists discover that indulging in junk food can aid in weight loss

It is common to assume that individuals who are overweight derive more pleasure from food compared to those with smaller bodies, but this is not accurate. Instead, individuals tend to experience increased pleasure from their diet as they gain weight.

Researchers have now identified the reasons behind this phenomenon, as well as how restoring the pleasure response can be facilitated by adopting a healthier diet.

“Obesity is often associated with an excessive enjoyment of food. People believe they cannot resist unhealthy food options,” explained Professor Stephan Lammel, a neuroscientist at the University of California, Berkeley and the senior author of the study, in an interview with BBC Science Focus.

“However, both our research and previous studies indicate the opposite: Over time, individuals may experience a decrease in food-related pleasure.”

These findings are linked to the role of dopamine, a brain chemical associated with rewards, motivation, and pleasure. Researchers have discovered that overweight mice have lower levels of a molecule called neurotensin, which impacts dopamine responses to food.

“Contrary to popular belief, individuals with obesity may not eat for pleasure. In reality, much of their eating habits are influenced by routines and emotional cues rather than pleasure or desire,” Lammel added.

To investigate this further, researchers fed a group of mice a high-fat, unhealthy diet and observed their eating behavior. The results showed that the mice preferred the high-fat diet over regular low-calorie foods, indicating a preference for unhealthy options.

However, when presented with high-calorie treats like butter, peanut butter, and chocolate, the mice showed less interest compared to those on a normal diet. This suggests that their food choices were driven by habits rather than pleasure.

Further experiments involving stimulating brain circuits connected to dopamine yielded interesting results. While normal weight mice responded positively to the treatment, overweight mice did not, indicating an issue with dopamine and neurotensin levels.

The researchers were able to correct this by switching some mice to a normal diet, resulting in a return to normal levels of neurotensin, dopamine function, and interest in high-calorie foods. Additionally, artificially restoring neurotensin levels in other mice led to weight loss and improved food motivation, mood, and mobility.

“Our findings suggest that targeting neurotensin signaling through genetic strategies could help rebalance food motivation and promote healthier eating habits,” Lammel stated.

It is important to note that this study was conducted on mice fed high-fat diets, so the results may not directly apply to obese individuals. Nevertheless, the implications for human health are promising.

When asked about the potential impact on people, Lammel commented, “It could potentially make it easier for individuals to maintain a healthy weight without solely relying on willpower or restrictive diets.”

About our experts

Stephen Lammel: Associate Professor of Neurobiology at the Department of Neuroscience at the University of California, Berkeley. Investigator at Weil Neurohub with a focus on neural circuits mediating motivation and reward. Member of the Helen Wills Neuroscience Institute.

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Source: www.sciencefocus.com

The Increased Importance of Exercise with Weight Loss Medication

For decades, traditional wisdom has believed that in order to lose weight, you have to eat less and move more. Of course, that’s easier said than done. That’s why drugs like Wegovy are so innovative. By suppressing appetite, they help to tackle the first part of the equation, which usually leads to dramatic weight loss. But what about the second one? If weight loss pills are reducing the number of scales, should we still head to the gym? And how do these drugs affect our athletic ability?

What has become clear is that it may be even more important for those taking these medications than those who don’t. The ability of semaglutide to induce rapid weight loss (see “How do they work?” below) also leads to a significant decrease in muscle mass. For example, a 2021 study of 95 people who were overweight or obese taking semaglutide found that their lean body mass was reduced by almost 10% on average, 68 weeks later.

This article is part of a special series investigating the GLP-1 agonist boom. Click here for details.

Lean body weight covers body tissues such as muscles and bones. Therefore, these results suggest that both are affected when taking weight loss medications, Signee Sørensen Torekov at the University of Copenhagen explains. These drugs guide people to burn fewer calories, so the body needs to break down fat, muscle, and even bones for nutrients.

“Our understanding is that up to about 40% of the overall weight loss seen in semaglutide is thought to be due to the loss of muscle mass,” he said.

Source: www.newscientist.com

Genetic Factors Could Contribute to Your Dog’s Weight Struggle, Just Like in Humans

Have you ever wondered why some dogs look naturally rounded, no matter how much they run around? After all, the same genes that contribute to human obesity are also found in our dogs.

in New genome researchscientists have identified several genes associated with obesity in dogs. This is a gene that we humans share. This means that our favorite furry friends (sorry, cats) will actually help researchers unlock new insights into weight gain, health and complex diseases.

Environmental factors such as Inexpensive availability of ultra-processed foods Scientists, commonly chosen for increased rates of obesity, emphasize that it is a complex condition with a large number of biological root causes. The main factor is hereditary Research from 2007 People estimate that there is 40-70% of people who develop obesity due to genes they inherit from their parents.

As Dr. Eleanor Rafansaid he will lead the academics with new research. BBC Science Focus, “If you're unlucky enough to get the genes that are prone to obesity, it manifests as a bigger appetite and makes it difficult to resist those drives. Slim people aren't morally good. You don't need to show that much willpower to maintain a healthy weight.”

To see if obesity in dogs is also hereditary, researcher Natalie Wallis and her team looked at the genes of a 241 pet Labrador retriever.

Oscar and Isla, and the Labrador used in this study. Photo credit: Natalie Wallis

Using a heterologous approach, they identified multiple obesity-inducing genes shared by dogs and humans. Among these, the gene dennd1b plays an important role in the way our cells process energy – has emerged as a particularly strong genetic association between human and dog obesity.

“By looking at just a few hundred Labrador retrievers, we discovered new biology about the associations of the whole species. We hope that more people will consider using dog genetic models for more scientific discoveries in the future, especially for complex diseases,” Wallis said. BBC Science Focus.

Not only does it provide scientists with new models to understand human diseases, but this study also helps to care for dogs. Pet obesity is on the rise, and at Royal Veterinary College in London Recently, we have reported 1 in 14 dogs It is recorded as overweight every year in the UK.

In the US, 2022 Pet Obesity Association (APOP) Survey It is found that 59% of dogs are overweight, indicating a wide range of issues in pet health. However, up until now, the genetic basis of dog obesity has not been extensively studied.

Dr. Eleanor Lafan takes chocolate Labrador retrievers. Photo credit: Dr. Eleanor Rafan

Understanding pet genetics may be a game changer for their care. “Our results underscore the importance of encouraging exercise and limiting food intake for pet dogs,” says Dr. Rafan.

“Many people still blame the owners of fat dogs, saying they are lazy or extravagant, and the same stereotypes are reflected on obese people. Our data shows that controlling food intake in high-risk dogs is much more difficult. It should actually change the way dogs deal with obesity. They should target high-risk dog owners and support effective management (rather than criticizing them).”

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Source: www.sciencefocus.com

Research: Elderberry juice high in anthocyanins may be an effective weight management aid

Consuming elderberry juice daily for one week (12 ounces of juice daily) significantly increases the gut microbial community associated with health benefits, according to a new randomized, placebo-controlled study. Compared to placebo, elderberry juice significantly increased Firmicutes and Actinobacteria and decreased Bacteroidetes. At the genus level, elderberry juice increased. FaecalibacteriumRuminococcaceae , and Bifidobacterium Bacteroidetes and lactic acid-producing bacteria decreased.

Elderberry is a small dark purple fruit that grows on the elderberry tree, which is native to Europe. Image credit: TheOtherKev.

More than 70% of adults in the United States are overweight or obese. The latest estimates indicate that 42% of adults suffer from obesity, and this is expected to increase to 48-55% by 2050.

Obesity has myriad and multifaceted causes. Proactive dietary management of obesity-related cardiometabolic complications includes dietary patterns that incorporate food sources rich in bioactive food components, such as the Mediterranean-style diet.

These dietary patterns include 5 to 10 daily servings of fruits and vegetables, which are rich sources of polyphenols that promote human health and longevity.

Anthocyanins are a diverse subclass of flavonoids that have been widely studied for health-promoting properties, including metabolic changes associated with obesity, such as diabetes, dyslipidemia, and cardiovascular disease.

Furthermore, research results ranging from translational studies in rodents to large prospective cohort studies show that anthocyanin-rich berries have a protective effect against obesity-related morbidity and mortality. It's proven.

The mechanisms of action of anthocyanin benefits include preventing the intestinal absorption of monosaccharides, promoting cellular metabolism in adipose and muscle tissue, and modulating the gut microbiome.

“We have previously shown that consuming 600 g of blackberries per day for one week increases insulin sensitivity as evidenced by dietary challenge testing and decreases in respiratory quotient by 24-hour indirect calorimetry. “We demonstrated that fat oxidation also increases.” Dr. Patrick Solverson and colleagues at Washington State University.

“The aim of this human study was to determine whether the metabolic benefits observed with other anthocyanin-rich berries also apply to elderberry.”

Researchers tested elderberry's effects on metabolic health in a randomized, placebo-controlled clinical trial of 18 overweight adults.

While maintaining a standardized diet, participants consumed either elderberry juice or a placebo with a similar color and flavor specifically designed by North Carolina State University's Food Innovation Lab.

Post-intervention clinical trials showed that participants who consumed elderberry juice had significantly increased amounts of beneficial gut bacteria, such as Firmicutes and Actinobacteria, and decreased amounts of harmful bacteria, such as Bacteroidetes. It was shown that

In addition to positive changes in the microbiome, elderberry intervention improved metabolism.

The results showed that elderberry juice lowered participants' blood sugar levels by an average of 24%, significantly improving their ability to process sugar after ingesting carbohydrates. Results also showed that insulin levels were reduced by 9%.

Additionally, the results suggested that elderberry juice may increase the body's ability to burn fat.

Participants who consumed elderberry juice showed a significant increase in fat oxidation, or the breakdown of fatty acids, after a high-carbohydrate meal or during exercise.

“Food is medicine, and science is catching up to that conventional wisdom,” Dr. Solverson said.

“This study contributes to a growing body of evidence that elderberry, which has been used as a folk medicine for centuries, has many benefits for metabolic as well as prebiotic health. .”

“Other berries also contain anthocyanins, but usually in lower concentrations,” he added.

“To get the same amount of anthocyanins found in 6 ounces of elderberry juice, you would need to consume 4 cups of blackberries a day.”

of findings appear in the diary nutrients.

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Christy Teets others. 2024. A 1-week elderberry juice intervention enhances fecal microbiota and suggests improved glucose tolerance and fat oxidation in a randomized controlled trial. nutrients 16(20):3555;doi: 10.3390/nu16203555

Source: www.sci.news

The reasons behind weight regain after losing it: a new understanding emerging

Losing weight can be difficult

Tero Vesalainen/Getty Images

Obese people often lose weight but gain it back, but this may be partly due to permanent changes in the DNA within fat cells, a discovery that could one day lead to new treatments. may lead to.

Approximately 85% of overweight or obese people lose at least one-tenth of their body weight get it back within a year.

Part of the reason is that low-calorie diets are difficult to maintain over long periods of time, but that likely plays a relatively small role, he said. Laura Katarina Hinte at the Federal Institute of Technology Zurich, Switzerland. “There's no way we all don't have enough willpower to keep off the weight we lose.”

Research shows that the brain interprets a sudden drop in body fat as dangerous; It responds by reducing the body's energy expenditure.

To learn more about this process, Hinte and his colleagues sampled adipose tissue from 20 obese patients, who were about to undergo bariatric surgery (a procedure that shrinks the stomach to help you feel full more quickly) and who had at least lost weight. It was analyzed two years later. 1/4 of the original weight. They also examined adipose tissue in 18 people with healthy weight.

Researchers have sequenced a type of genetic molecule called RNA that codes for proteins in fat cells. They found that obese people had increased or decreased levels of more than 100 RNA molecules compared to healthy weight people, and these differences persisted two years after weight loss.

These changes appear to exacerbate inflammation and disrupt the body's state. Fat cells store and burn fat, both of which increase the risk of future weight gain, according to team members. Ferdinand von Mayenalso at the Federal Institute of Technology Zurich.

To examine whether these RNA changes could cause rebound weight gain, the researchers first determined that similar changes persisted even after obese mice lost weight. These mice, as well as mice of healthy weight, were then fed a high-fat diet for one month. The previously obese mice gained an average of 14 grams, while the other mice gained only 5 grams.

The researchers also found that fat cells from previously obese mice took up more fat and sugar than fat cells from other mice when cultured in a laboratory dish. Taken together, these results show how obesity-related RNA changes can increase future weight gain, von Mayen said.

Finally, the research team found that molecular tags, or epigenetic marks, on the DNA within fat cells appear to drive RNA changes associated with obesity. They change RNA levels by changing the structure of the DNA that encodes it.

Although the study did not look for these molecular tags in the people studied or see if they regained the weight they lost, the findings likely apply from mice to humans. states. henriette kirchner At the University of Lübeck, Germany.

This is based on similarities between the physiology of these species and how the environment can change the way their genes work, known as epigenetics, she says. In the coming decades, Kirchner says drugs that target epigenetics could help treat obesity.

topic:

Source: www.newscientist.com

Scientists may have uncovered the key to solving a significant weight loss mystery

When it comes to weight loss, one universal truth stands out: losing body fat is challenging, and keeping it off can be even more difficult. A recent study may shed some light on why this is the case: adipose tissue, or body fat, retains a sort of “memory” even after cells have become obese.

“This discovery potentially helps explain the changes that occur in adipose tissue during weight fluctuations,” explained Dr. Ferdinand von Mayen, an assistant professor at ETH Zurich’s Faculty of Health Sciences and Technology, in an interview with BBC Science Focus.

Dr. von Mayen and his team observed transcriptional changes in human cells, which are responsible for regulating genetic material, in individuals’ adipose tissue before and after a 25 percent reduction in BMI. “We found that even after weight loss, the genetic regulation in adipose tissue did not fully return to normal, indicating that the body is programmed to regain lost weight,” he added.

While this news may be disheartening for those on a weight loss journey, Dr. von Mayen hopes that this study will help destigmatize weight fluctuations. “There is a molecular mechanism at play that influences weight regain, and it’s not simply a matter of willpower,” he emphasized.

He also stressed the importance of prevention in addressing the global obesity epidemic. “Early intervention is key, as it is much harder to lose weight once it has been gained. Implementing healthier lifestyle choices at a societal level is crucial in combating this issue,” Dr. von Mayen noted.

About our experts

Dr. von Mayen: I specialize in researching obesity and metabolic diseases at the Nutritional and Metabolic Epigenetics Laboratory at ETH Zurich.

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Source: www.sciencefocus.com

Study finds new weight loss drug decreases appetite without compromising muscle mass

Researchers have identified a new drug similar to Ozempic that aids in weight loss without causing muscle loss. This drug, known as NK2R, works by suppressing appetite and boosting calorie burning. According to scientists, it has been successful in promoting weight loss while avoiding negative side effects such as nausea. The team of 47 researchers believe that NK2R could be a valuable option for individuals who have not seen results with other weight loss treatments.

Associate Professor Zach Gerhart-Hines, a metabolic researcher at the University of Copenhagen and co-author of the study, noted that their drug, unlike Ozempic, did not trigger nausea and also resulted in muscle relief rather than muscle loss. The drug targets specific neural circuits in the brain and affects blood sugar, weight, and cholesterol levels.

While Ozempic mimics the hormone GLP-1 to reduce hunger, NK2R works differently by targeting a molecule naturally present in the body’s cells called NK2R. When tested on overweight mice, the drug led to weight loss and decreased food intake.

However, some health experts are cautious about the effects of this treatment on humans, as it is currently based on animal studies. Dr. Adam Collins, an associate professor of nutrition at the University of Surrey, expressed skepticism about the research’s applicability to humans.

Clinical trials of NK2R in humans are scheduled to begin within the next two years.

About our experts:

Dr. Zach Gerhart-Hines is an associate professor at the University of Copenhagen, Denmark, focusing on diet, circadian clocks, and metabolism.

Dr. Adam Collins is an Associate Professor at the University of Surrey with expertise in weight loss, metabolism, and nutrition.

read more:

Source: www.sciencefocus.com

Discovery of Metabolic Compounds that Control Appetite and Weight

Research has revealed a new metabolic pathway involving beta-hydroxybutyric acid (BHB). Previously known as a liver-produced fuel, BHB is now found to be attached to amino acids by the enzyme CNDP2. The most abundant BHB amino acid, N-β-hydroxybutyryl phenylalanine (BHB-Phe), can impact body weight and metabolism in animal models.



Beta-hydroxybutyric acid (BHB) is an abundant ketone body. All BHB metabolic pathways known to date involve the interconversion of BHB and primary energy intermediates. Moya Garzon others. BHB et al. identified a previously undescribed BHB secondary metabolic pathway via CNDP2-dependent enzymatic binding of BHB and free amino acids. Image credit: Moya-Garzon others., doi: 10.1016/j.cell.2024.10.032.

Mammals have developed intricate nutrient response pathways linking external energy sources with internal metabolic balance.

These pathways involve changes in cellular energy metabolites serving as both fuel sources and downstream regulators.

BHB, a ketone body, is a key example whose levels rise during low carbohydrate conditions like starvation, intermittent fasting, or ketogenic diet.

In a recent study, Professor Yong Xu of Baylor College of Medicine and team investigated how BHB-Phe, the most common BHB amino acid, affects eating habits and body weight in mice.

“Brain neuron groups regulate feeding behavior, so we mapped the brain to identify regions activated by BHB-Phe,” explained Professor Xu.

“BHB-Phe activated neural populations in the hypothalamus and brainstem, suppressing feeding and leading to weight loss.”

In contrast, mice lacking CNDP2 enzyme, deficient in BHB-Phe, ate more and gained weight.

Interestingly, CNDP2 also produces Lac-Phe, a compound discovered earlier by the research team.

“Lac-Phe from exercise can reduce food intake and obesity in mice,” added Professor Xu.

“But do Lac-Phe and BHB-Phe trigger effects by activating the same brain neurons?”

This discovery points to a possible disruption of the BHB-Phe pathway, present in humans, in obesity and other conditions, warranting further research to understand the mechanism.

“This study unveils new prospects,” commented Dr. Jonathan Long from Stanford.

“In the future, using BHB-Phe to promote weight loss without carbohydrate restrictions may be feasible.”

Featured in this week’s cell journal.

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Maria Dolores Moya-Garzon others. The β-hydroxybutyrate shunt pathway produces anti-obesity ketone metabolites. cell published online on November 12, 2024. doi: 10.1016/j.cell.2024.10.032

Source: www.sci.news

The unexpected weight loss caused by Canada’s gravity anomaly

In certain areas of the world, such as Canada’s Hudson Bay, gravity is slightly lower than in other areas.

This is because an object with more mass has more gravity, and since Earth’s mass is not uniform, gravity varies from place to place. However, you need a very accurate scale to notice it. Hudson Bay’s gravity is about four thousandths of a percent lower than Earth’s average.

When scientists discovered this anomaly in the 1960s, they developed two theories to explain it. The first is that the Earth’s crust is still recovering from the last Ice Age.

About 20,000 years ago, the huge Laurentide ice sheet covered North America. The weight of the ice, which was more than 3 kilometers (almost 2 miles) thick in places, pushed down on the continent’s crust.

When the Ice Age ended, the Laurentide melted rapidly, but the Earth’s crust slowly returned to normal. It rebounds by about 12 mm (0.5 inch) each year, meaning it will take another 300,000 years to return to its original position. This indentation left in the Earth’s crust means that Hudson Bay has slightly less mass and therefore slightly less gravity.

The second theory concerns the movement of the mantle beneath the Earth’s crust.

The mantle is made of molten rock heated by the Earth’s core. It rises over geological time scales and then sinks again as it cools. This creates convection currents that move the plates. Ocean currents can also pull continents downward, slightly reducing mass and gravity in the area.

Satellite measurements in 2002 revealed both theories to be correct. The Hudson Bay gravity anomaly is caused by a combination of mantle convection and the legacy of the Laurentide ice sheet. Therefore, even after the Earth’s crust has fully rebounded, gravity in this part of the world will remain slightly lower than average.

This article answers the question (asked by Victor Gregory via email): “Is it true that people in Canada weigh less?”
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Suppressing Appetite to Lose Weight: The Effects of Weight Loss Drugs on Eating and Exercising Desires

Weight loss drugs may reduce people's desire to exercise

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Semaglutide, found in medicines such as Ozempic and Wigovy, reduces the amount of movement in mice. This finding suggests that these weight loss drugs may reduce people's motivation to exercise.

Semaglutide helps treat type 2 diabetes and obesity by mimicking a hormone called GLP-1, which regulates blood sugar and suppresses appetite. GLP-1 also suppresses activity in brain areas involved in reward processing and craving. This may explain why people taking semaglutide-based drugs no longer find eating as rewarding or pleasurable as they did before taking the drug. This is also probably why some studies show that semaglutide may also be helpful in treating substance use disorders.

ralph dileone Researchers at Yale University wanted to know whether semaglutide also affects other rewarding behaviors, such as exercise, which is known to improve mood and memory. So they gave seven mice semaglutide and an equal number a placebo and measured how far the mice ran on an exercise wheel each day.

On average, patients treated with semaglutide ran about half the distance as those given a placebo. This suggests that motivation for exercise may be low.

To further test this, the researchers administered semaglutide to another group of 15 mice and a placebo for 5 days to another group of similarly sized mice, and investigated their willingness to exercise on a wheel. did. But this time, the exercise wheel locked up periodically while the animal was running on it. To release the lock, the mouse had to press a lever with its nose. Each time the wheel locked, it became progressively more difficult to unlock, requiring the mouse to press the lever many more times. “Eventually they quit,” says DiLeone, who presented these findings at the Society for Neuroscience meeting in Chicago on October 7. “We call that their breakpoint. It's a proxy for how willing they are to access the wheel.”

The maximum number of lever presses in the semaglutide-treated mice was, on average, 25% lower than in the control animals. The researchers repeated the experiment in obese mice and found similar results.

Taken together, these findings suggest that semaglutide-based drugs, such as Ozempic and Wigovy, may reduce motivation to exercise, similar to reducing food and drug cravings. Masu. But DiLeone says there's still no evidence that this applies to humans. This could be because most of the data on Wegovy and Ozempic comes from people participating in weight-loss programs that include exercise, he says.

Still, these findings highlight that these drugs can interfere not only with negative behaviors but also with positive ones. ”[This] Data suggests there are still motivated behaviors that can be changed [with semaglutide] I haven't heard it yet.'' Karolina Skibicka at Penn State University.

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Research shows new medication similar to Ozempic results in 13% reduction in body weight

Weight-loss medications like Ozempic and Wegovy have been under discussion for some time, but new research suggests there may be better alternatives. Enter Amicretin, a novel weight-loss treatment available in pill form rather than injection.

In the initial human trials of this new weight loss medication, the developer Novo Nordisk A/S (the company behind Ozempic) saw promising results: participants taking Amicretin lost an average of 13.1 percent of their body weight over a 12-week period.


So, how does this new weight loss pill function? Amicretin is a dual-acting drug that emulates the effects of two hormones crucial in weight loss: amylin and glucagon-like peptide-1 (GLP-1), which help curb hunger and regulate appetite.

Published in the journal Diabetology, the study compared average weight loss in three groups with BMIs between 25 and 39.9 who did not have diabetes.

By the end of the 12-week study, subjects taking two 50 mg tablets of Amicretin lost 13.1% of their body weight, compared to 10.4% in those taking one 50 mg tablet. In contrast, the placebo group only lost an average of 1.1% of their body weight throughout the study.

Compared to other weight loss drugs, a recent study in JAMA Internal Medicine found that patients taking another weight-loss drug, Maunjaro, lost 5.9% body fat in 3 months, while those on Ozempic saw a decrease of 3.6%.

“The difference from injectable treatments is significant,” states obesity expert Christopher Clemmensen. “The dual mode of action offers promise, making Amicretin a valuable advancement for Novo Nordisk.”

While weight-loss drugs show promise in combating obesity worldwide, further confirmation awaits larger trials on individuals with chronic conditions. Professor Navid Sattar emphasizes the importance of developing safe and accessible medications for the millions suffering from obesity.

Excitement surrounds this early-stage study of a novel oral weight-loss medication combination due to its rapid effects on body weight.

About our experts

Associate Professor Christopher Clemmensen leads the Clemmensen Group at the University of Copenhagen, studying biological weight regulation and developing obesity treatment strategies. His research appears in respected publications such as Natural Metabolism and Molecular Metabolism.

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The Guaranteed Method to Lose Weight and Maintain it: The Power of Fasting

In the past, intermittent fasting was not a choice due to scarcity of food. People would go hours or days without eating. Today, we have access to food whenever we want. This shift in eating habits has led to questions about the benefits of fasting and its potential reintroduction.

Intermittent fasting usually involves limiting food intake to specific times or days, like eating only for eight hours out of 24 (16:8 diet) or restricting calories for two days out of seven (5:2 diet).


Strong Points

Intermittent fasting can help with weight loss, particularly fat loss, as it reduces overall caloric intake. It also provides structure to eating days and can be flexible and intuitive. Some benefits include decreased hunger, lower levels of the hunger hormone ghrelin, reduced appetite, and improved fat burning.

Fasting may also lower the risk of type 2 diabetes and improve vascular health. Research shows that intermittent fasting is beneficial for cardiometabolic health and may have positive effects on long-term cardiovascular health.

There is evidence to suggest that fasting can protect against issues related to aging, improve autophagy, and potentially benefit brain health and cancer risk, but more research is needed to support these claims.

Cons

Concerns about fasting include potential muscle loss and the lack of long-term studies to support its safety. Some studies suggest that restricting eating to less than eight hours a day could increase the risk of death from cardiovascular disease, but data collection methods and sample sizes in these studies may be flawed.

There is also a risk of reduced protein intake with intermittent fasting, which could be problematic for some individuals, especially those with a history of eating disorders or health conditions that require regular meals.

Experts recommend ensuring adequate protein intake and incorporating strength training if trying intermittent fasting. It’s important to approach fasting like any other diet, not as a permanent solution, and to pay attention to food choices when breaking the fast.

About our experts

Dr. Jason Fung, Dr. Darryl Gioffre, Brady Holmer, and Drew Price are experts in their fields and have published work related to intermittent fasting, nutrition, and health.

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