The wiring of our neurons evolves over the decades
Alexa Mousley, University of Cambridge
Our brain’s functionality isn’t static throughout our lives. We know that our capacity for learning and the risk of cognitive decline fluctuate from infancy to our 90s. Recently, scientists may have uncovered a possible reason for this change. The wiring of our brains seems to experience four key turning points at ages 9, 32, 66, and 83.
Previous studies indicate that our bodies undergo three rapid aging cycles around the ages of 40, 60, and 80. However, the complexity of the brain complicates our understanding.
The brain consists of distinct regions that communicate through white matter tracts. These tracts are wire-like structures formed by long, slender projections known as axons, which extend from neurons, or brain cells. These connections significantly influence cognitive functions, including memory. Nevertheless, it was uncertain if this substantial change in wiring transpires throughout one’s life. “No one has combined multiple metrics to characterize stages of brain wiring,” states Alexa Mousley from Cambridge University.
In an effort to bridge this knowledge gap, Maudsley and his team examined MRI scans of roughly 3,800 individuals from the UK and US, primarily white, spanning ages from newborns to 90 years. These scans were previously gathered as part of various brain imaging initiatives, most of which excluded individuals with neurodegenerative diseases or mental health issues.
The researchers discovered that the brain wiring of individuals reaching 90 years old typically progresses through five significant stages, separated by four primary turning points.
In the initial stage, from birth to age nine, the white matter tracts between brain areas seem to become longer, more intricate, and less efficient. “It takes time for information to travel between regions,” explains Mausley.
This may be due to the abundance of connections in our brains as young children. As we age and gain experiences, we gradually eliminate unused connections. Mausley notes that the brain prioritizes making broader connections, beneficial for activities like piano practice, though at the expense of efficiency.
However, during the second stage, from ages 9 to 32, this trend appears to reverse, potentially driven by the onset of puberty and hormonal shifts affecting brain development. “Suddenly, your brain’s connections become more efficient. Connections become shorter, allowing information to traverse more swiftly,” says Mausley. This could enhance skills such as planning and decision-making, along with improved cognitive abilities like working memory.
The third stage, which spans from 32 to 66 years, is the longest phase. “During this stage, the brain continues to change, albeit at a slower rate,” Mausley explains. Specifically, she notes that connections between regions have a tendency to become less efficient over time. “It’s unclear what exactly triggers this change; however, the 30s often involve significant lifestyle alterations, like starting a family, which may play a role,” she adds. This inefficiency might also stem from general physical wear and tear, as noted by Katia Rubia from King’s College London.
From ages 66 to 83, the connections between neurons in the same brain area tend to remain more stable than those among different regions. “This is noteworthy, especially as the risk of developing conditions like dementia increases during this period,” Mausley remarks.
In the final stage, from ages 83 to 90, connections between brain regions weaken and rely more frequently on “hubs” that link multiple areas. “This indicates that there are fewer resources available to maintain connections at this age, leading the brain to depend on specific areas to serve as hubs,” Mausley explains.
Understanding these alterations in the brain could provide insights into why mental health issues arise, typically before the age of 25, and why individuals over 65 are particularly vulnerable to dementia, she states.
“It’s vital to comprehend the normal stages of structural changes in the brain throughout the human lifespan, so future research can explore deviations that occur in mental health and neurodegenerative disorders,” Rubia notes. “Grasping the causes of these deviations can assist us in pinpointing treatment strategies. For instance, we might examine which environmental factors or chemicals are responsible for these differences and discover methods to counteract them through treatments, policies, and medications.”
Nevertheless, Rubia emphasizes the need for further research to determine whether these findings apply to a more ethnically and geographically diverse population.
Complex problem solving can arise sooner in child development than previously believed
PlusOnevector/Alamy
Research reveals that four-year-olds can devise efficient strategies for complex challenges, such as independently creating sorting methods akin to those used by computer scientists. The researchers assert that these abilities appear much earlier than once thought, warranting a reevaluation of developmental psychology.
Past experiments led by Swiss psychologist Jean Piaget popular in the 1960s, required children to physically arrange sticks by length. His findings indicated that structured strategies didn’t emerge until around age seven, as children tended to experiment haphazardly through trial and error.
Contrarily, recent work by Huiwen Alex Yang and his team at the University of California, Berkeley, shows that a notable fraction of four-year-olds can create algorithmic solutions for the same task, with more than a quarter exhibiting these skills by age five.
“Perhaps we haven’t given our children enough credit,” Yang states. “We must delve deeper into their reasoning capabilities.”
In a study involving 123 children aged 4-9, researchers asked them to sort digital images of bunnies by height. Initially, they could view groups of bunnies and directly compare their heights, allowing all children to sort them aptly using straightforward methods.
However, once the heights were obscured, the children had to compare only two bunnies at a time while being informed whether their order was correct. This approach necessitated the development of new strategies, as they couldn’t see the entire group simultaneously.
The researchers examined the children’s application of these new strategies, looking for evidence of known solutions and demonstrated instances where children utilized established algorithms. It was found that overall, children frequently outperformed random chance. Remarkably, they independently identified at least two efficient sorting algorithms recognized in computer science: Selection Sort and Shaker Sort.
In 34% of trials, children employed various comparisons, signaling their use of known sorting algorithms for a portion of the time. Out of a total of 667 tests run, the children utilized selection and shaker sorting in 141 instances, with some employing combinations of both strategies. Notably, 67 out of 123 children demonstrated at least one recognizable algorithm, and 30 children used both at different stages in the experiment.
Nonetheless, the age of the children directly influenced how many used algorithms. Only 2.9% of four-year-olds applied identifiable methods, while this rose to 25.5% among five-year-olds and 30.7% for six-year-olds. By age nine, over 54% were using identifiable algorithms.
“This has long been a challenge to Piaget,” remarks Andrew Bremner from the University of Birmingham, UK. He acknowledges Piaget’s groundbreaking contributions to developmental psychology in setting stages for learning but emphasizes that Piaget often designed experiments without proper controls. “Critics have been eager to illustrate that children can achieve more than Piaget claimed.
Essentially, while Piaget initially had a correct understanding of child development, his assessments of the ages at which children achieve certain milestones were overly pessimistic. This latest study strengthens the evidence supporting earlier development stages. Interestingly, it revolves around sorting. Bremner indicates this as the last bastion of Piaget’s work, proving applicable to younger children than once believed.
“Children can successfully navigate this particular problem much sooner than we anticipated,” states Bremner. “They do not approach the world as mere blank slates, but rather implement strategic techniques in problem-solving.”
Sam Wass from the University of East London points out that Piaget contended that children needed a comprehensive grasp of complex systems before they could devise strategies to engage with them, a notion he is finding increasingly unnecessary.
“This research signifies a significant trend in psychology that contests the assumption that intricate thoughts and understanding are prerequisites for executing complex behaviors,” notes Wass. “The study illustrates that complex behaviors may emerge from a far simpler array of rules.”
The rapper 50 Cent (born Curtis Jackson) became a household name in 2005. British classrooms were filled with teenagers sporting Jackson’s G-Unit attire, while his catchy tracks dominated the airwaves. His remarkable journey—from surviving being shot nine times to becoming one of the world’s biggest hip-hop stars—is the stuff of legends.
That year, 50 Cent sold over a million copies of his sophomore studio album, *The Massacre*, in just one week. To capitalize on this superstar’s success, his label Interscope Records devised a dual strategy: a Hollywood biopic (*Get Rich or Die Tryin’*) and a licensed video game, *50 Cent: Bulletproof*, both set for release by November 2005. “It feels like an action movie,” he remarked.
The game, developed by a British company previously known for the *Fight Club* tie-in, aimed to create a thrilling escape through the 128-bit era. Unfortunately, the project only lasted 11 months. “I remember arriving at the office at 7am and not leaving until around 11pm,” recalls game artist Hanlandawa. “We all lived on a KFC diet. 50 Cent became my obsession. I even read a doctor’s report of his shooting.”
Game designer Haydn Dalton added, “It’s amusing because this game revolves around guys from the hood, yet here I am—a white guy from northwest England—writing the in-game dialogue.”
Take a photo first and ask questions later… Photo: THQ
As of November 20th, this year, 50 Cent finds himself embroiled in a shadowy underworld filled with dangerous terrorists, vicious biker gangs, and mobsters. He navigates the cityscape—shooting first and asking questions later—tracking down the individuals who shot him and aiding his G-Unit crew (including Tony Yayo, Young Buck, and Lloyd Banks).
Similar to the *A-Team*, each G-Unit member provides unique skills (Yayo as the explosives expert, Banks as the lock-pick). The script, penned by *Sopranos* writer Terrence Winter, features cinematic cutscenes where 50 Cent interacts with the corrupt Detective McVicar, adding to the game’s intensity.
He voices a corrupt cop, spurred on by Madcap Eminem, who constantly demands cash to fund his children’s expensive karate lessons. Accompanying the troubled McVicar is Dr. Dre, providing the voice for a hardened arms dealer, who cryptically remarks “it’s serious shit” every time 50 Cent purchases a rocket launcher. The game is further enhanced by a soundtrack filled with licensed 50 Cent tracks, pushing players to immerse themselves in the action while songs like *Wanksta* play in the background.
“We were fortunate because 50 Cent felt like more than just a rapper—he felt like a superhero,” explains game director David Broadhurst. “The goal was to make him the Black James Bond.” However, Broadhurst acknowledges that the UK development team missed out on some of the glamour and sheen of the project. “Vivendi kept us somewhat distanced from both 50 Cent and G-Unit. All audio was sent to us. I remember how invested 50 was in vitamin water, which meant I had to include drinks in the game as purchasable items.”
50 Cent concept art: Bulletproof. Photo: Vivendi Universal Games
Randhawa recalls unique requests too, such as G-Unit member Tony Yayo, who constantly sought revisions to perfect his character’s appearance. “I knew I did a good job on Yayo,” laughs Randhawa. “The executive producer even remarked that other G-Unit members thought I completely captured Yayo’s distinct look!”
According to Dalton, the initial vision for *50 Cent: Bulletproof* leaned toward an open-world format similar to *Grand Theft Auto: San Andreas*. Early iterations allowed 50 to navigate the subway system to traverse New York City, but tight deadlines necessitated a more straightforward experience. Dalton elaborated, “One of our concepts was to have 50 managing street-level employees, raising drug funds for him.”
Unlike other rap-themed games such as the *Def Jam Fighting* series, which often portrayed rappers as adversaries, *Bulletproof* presented 50 Cent in a hero’s role. “It was refreshing to see a project where rappers were depicted as complete heroes instead of anti-heroes,” commented Sha Money XL, a former executive producer at G-Unit Records.
“If I filmed a G-Unit in 2005, we were ready to roll.” Photo: Vivendi Universal Games
Sha Money XL led the soundtrack for *50 Cent: Bulletproof*, acknowledging that the game’s title could easily be perceived as inciting violence by some of 50 Cent’s adversaries. “Perhaps some wanted to test whether 50 Cent was genuinely bulletproof. But if they were filming G-Unit in 2005, we were prepared to shoot.”
This polarizing aspect likely explains the mixed critical reception of *50 Cent: Bulletproof*. The game garnered a mere 52% score on Metacritic, with reviewers pointing to its cumbersome aiming system. Broadhurst believes there was an underlying bias against productions led by black heroes.
“It was evident that many reviewers didn’t fully engage with *Bulletproof*,” Broadhurst remarked. “Maybe they had issues with the black hero who was associated with licensed games or had ties to the drug trade. I’m still surprised that when people picked it up, they found it surprisingly enjoyable.”
Plans for a direct sequel to *Bulletproof*, focused on urban conflict and G-Unit’s survival in America amidst a Civil War backdrop, were scrapped. However, *50 Cent: Bulletproof* paved the way for the 2009 sequel, *50 Cent: Blood on the Sand*, which has since gained a reputation as an underrated title.
These two titles featuring 50 Cent did not spark a wave of hip-hop video games. Dalton reflects, “50 Cent was truly the last global mainstream rap superstar. Despite our game generating significant revenue, the genre hasn’t produced a clear successor in terms of rap games.”
A complicated licensing agreement makes a remaster of 50 Cent unlikely. However, for those looking to relive 2005, securing an original copy on eBay is a must.
Dalton concludes, “Yes, our game was sprung together quickly, but I have no regrets. If you check Reddit, you’ll find a nostalgic community reminiscing about what we created. I doubt a Drake game would ever reach the same popularity, especially if it lacked the grit of earlier titles.”
Dean Spears and Michael Geruso (Bodley Head (UK); Simon & Schuster (US))
Current estimates suggest that four-fifths of all humans who will ever be born have already come into existence. The global number of births peaked at 146 million in 2012 and has been on a decline ever since, indicating that the world population is set to peak and decrease by the 2080s.
This decrease won’t be gradual. Fertility rates are already below replacement level in several nations, including China and India, leading to a rapid decline in population as quickly as it rose. This new controversial book argues that the planet could hold fewer than two billion people in the coming centuries.
“There’s no scenario where individuals worldwide are likely to opt for fewer children than required to replace themselves, leading to a drastic population reduction,” assert economists Dean Spears and Michael Geruso in After the Spike: Risks of Global Depopulation and Cases for People.
You might consider this a positive development. Could it help alleviate pressing environmental challenges? Not according to the authors. They assert that while population size does hold significance, adjusting other factors, such as the speed of global warming, is even more critical. The chance to lessen our carbon footprint through population reduction has mostly passed.
Spears and Geruso highlight numerous advantages of a large population. More individuals can lead to greater innovation and economies of scale, making technologies like smartphones feasible. “The abundance of neighbors enhances our potential,” they state.
Thus, their perspective is not about reducing the global population but rather stabilizing it. The challenge lies in the fact that even with the right political determination, the path to achieve this is unclear.
As we become more affluent, we are increasingly hesitant to give up career and leisure opportunities for parenthood.
The authors contend that while some government strategies may yield short-term results, no country has sustainably altered long-term demographic trends. Consider China’s one-child policy—it is often credited with curtailing population growth but did it genuinely do so? Spears and Geruso present ambiguous data on China’s population in relation to its neighbors before, during, and after these policies were enacted, raising the question of discernible differences based on their observations.
Efforts to reverse the declining fertility rates have also faced failure, they argue. In Romania, after the ban on abortion in 1966, birth rates surged but soon declined again. Sweden’s approach has been to incentivize through subsidies for childcare, yet its fertility rates remain below replacement level.
Attempts to boost fertility with financial incentives are likely doomed to fail, according to Spears and Geruso. While some claim that they would have more children if financial means allowed, the reality is that as people gain wealth, the tendency to have fewer children increases.
The focus should be on addressing what individuals need to balance rather than simply financial capability, according to the authors. As affluence grows, there is a reluctance to sacrifice careers and leisure for childbearing. Even technological advancements are not expected to change this trajectory, they conclude.
This book presents an unwaveringly optimistic viewpoint regarding many issues, but it acknowledges the complexity of stabilizing population levels. It effectively demonstrates that dire predictions of widespread famine with population growth have proven incorrect and suggests long-term trends toward healthier, longer lives remain possible. “Fears of a depleted, overpopulated future are outdated,” they argue.
But is that truly the case? Spears and Geruso also emphasize that food prices play a key role in determining hunger levels, yet it’s worth noting that food prices are presently rising as a consequence of escalating climate change. For a substantial portion of the population, uncertainty persists regarding whether conditions will continue to improve.
This book is undoubtedly provocative and may not provide an easy read, as Spears and Geruso delve into their primary assertions. However, if you believe that understanding the impact of a declining population is simple, and if you consider it a positive trend, this book is essential reading.
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Enthusiasts of Marvel movies and comics might recognize the tale of Thor’s Hammer, Mjolnir. This metal was crafted from the core of a dying star. While the power of the God of Thunder is not accessible to anyone, some of the heavy metals around us might originate from a long-dormant planet.
Similar to living beings, stars experience a life cycle. For stars with less than about 10 times the mass of the sun, the concluding phase is a White Dwarf. At this point, stars are compressed to the density of Earth and reach temperatures of around 100,000 Kelvin, approximately 100,000°C or 180,000°F. Unlike other stars, they cease to fuse elements in their cores for energy. Instead, they maintain their structure through Quantum mechanical principles and slowly release heat. This is why scientists often refer to white dwarfs as The dead star.
Nevertheless, under certain conditions, a white dwarf can experience one last surge of energy. There exists a limit to a white dwarf’s size, specifically 1.4 times the mass of the sun. If a star exceeds this threshold, gravitational forces can overpower its structural support, caused either by accumulating surrounding gas and dust or by merging with another white dwarf. This rapid compression ignites a chain reaction of fusion, culminating in an explosion known as a Type IA Supernova. Researchers estimate that such an explosion occurs in the Milky Way every 100-700 years.
A group of astrophysicists aimed to explore this phenomenon along with a rarer alternative. If a star is spinning while accumulating material, it can collapse into something even denser, a Neutron Star, and eject excess material without undergoing an explosion. The team simulated the aftermath of six different scenarios where the white dwarf collapsed after surpassing the size limit, known as Post Bounce. In these simulations, they adjusted various parameters, such as speed, width, temperature, and size thresholds of the white dwarfs.
They then controlled the initial conditions, including the mass of the white dwarf. Alkar simulated the behavior of low-energy particles referred to as liquid physics Neutrino 2D. Given the computational demands, astrophysicists typically simulate only a fraction of a second of post-bounce behavior. However, this team extended their simulation to 4.5-7 seconds to gain a deeper understanding of how ejected layers from white dwarfs behave.
The simulated white dwarf quickly collapsed, transitioning from a slower rate of 0.8 seconds to a rapid 0.04 seconds. The scenario diverged, with the unspinning white dwarf erupting into a supernova, while the spinning white dwarf transformed into a neutron star. In this latter case, the remnants of the stars were so densely packed that neutrinos collided with them, heating them up and ejecting them from the star.
The focus then shifted to the ejected material. The mass of material expelled ranged from 0.005 times to 0.05 times the mass of the sun, equivalent to about 1,700 to 17,000 Earth masses. Heavier elements like nickel can form during this process.
The researchers concluded that the outer layers ejected from collapsing white dwarfs could change rapidly during these events. They discovered that the material released was initially rich in protons and formed lighter elements but later became enriched in neutrons and heavier elements.
The team recommended developing more advanced 3D models of white dwarfs prior to their collapse for future studies. They suggested that astrophysicists could utilize these models to estimate the contribution of elements in the solar system originating from white dwarf collapses.
Every year, tens of thousands of young women opt to freeze their eggs. This procedure can be costly and at times painful, with numbers rising as more Americans delay childbirth.
However, many uncertainties surround the process: What is the optimal donor age for egg freezing? What are the success rates? And importantly, how long can frozen eggs remain viable?
Finding reliable answers to these questions is challenging. During the significant downsizing at the Centers for Disease Control and Prevention, the Trump administration disbanded a federal research team dedicated to collecting and analyzing data from fertility clinics aimed at enhancing outcomes.
According to Aaron Levine, a professor at Georgia Tech’s Jimmy and Rosalyn Carter School of Public Policy, who collaborated with the CDC team on research, the dismissal of the six team members was “a real, serious loss.”
“They held the most extensive data on fertility clinics, focused on ensuring truthfulness in patient advertising,” stated Barbara Collura, CEO of the National Infertility Association.
Collura emphasized that losing the CDC team is a significant blow to both couples facing infertility and women contemplating egg freezing.
These layoffs come amidst rising political interest in declining U.S. fertility rates. President Trump has dubbed himself the “infertile president” and signed an executive order aimed at expanding access to in vitro fertilization.
“The White House is committed to IVF and remains focused on it,” Collura noted.
With one in seven married or unmarried women experiencing infertility, she remarked, “Looking at these statistics, it’s disheartening—and not surprising—that our public health agencies have chosen to sidestep this issue.”
When asked about the team’s elimination, a health and welfare spokesperson commented that the administration is “in the planning stage” of transitioning maternal health programs to a new Healthy America initiative, offering no further details.
The scientists from the National Assisted Reproductive Technology Surveillance System were working to address numerous questions surrounding IVF research.
“We lack comprehensive data on the success rates of egg freezing for personal use because it’s relatively new and tricky to track,” Dr. Levine explained.
This uncertainty weighs heavily on women wishing to have children. Simeonne Bookal, who collaborates with Collura at Resolve, froze her eggs in 2018 while waiting to find the right partner.
She got engaged earlier this year, with her wedding scheduled for next spring. At 38, she expressed that having her eggs banked offers her a “security blanket.”
Though she still has reservations about her chances of conceiving, the frozen eggs provide her some assurance.
The precise success rate of the egg freezing procedure remains ambiguous, as many published studies are based on theoretical models that utilize data from infertile patients or egg donors, which differ significantly from women preserving their eggs for future use.
Some studies provide limited insights, often involving fewer than 1,000 women who thaw their eggs and undergo IVF, according to Dr. Sarah Druckenmiller Cascante, a Clinical Assistant Professor of Obstetrics and Gynecology at Nyu Langone and author of a recent review paper on this topic.
“The available data is scant, and it’s crucial to be transparent with patients about this,” she said.
“I wouldn’t regard it as a guaranteed insurance policy. While it could lead to a baby, it’s more about improving the chances of having a biological child later in life, especially if done at a younger age.”
The CDC team maintained a database known as the National ART Surveillance System, established by Congress in 1992. This tracked success rates for various fertility clinics but now faces an uncertain future without continuous updates.
While the Society for Assisted Reproductive Technology offers similar databases to researchers, they are not as comprehensive as the CDC’s since they contain data from approximately 85% of U.S. fertility clinics.
According to Sean Tipton, Chief Advocacy and Policy Officer for the American Association of Reproductive Medicine, no dedicated research team oversees the database.
The surge in women opting to bank their eggs for future use has intensified the scrutiny regarding the risks and benefits of freezing eggs.
This procedure was regarded as non-experimental as of 2012. In 2014, only 6,090 patients opted to bank their eggs for fertility preservation. Fast forward to 2022, and that number soared to 28,207, with 39,269 recorded in 2023, the latest year for which data is available.
Amidst the Trump administration’s focus on declining US fertility rates, recent data from the Centers for Disease Control and Prevention indicates that births remained relatively stable in 2024, increasing by 1% compared to the previous year.
In the United States last year, there were 3,622,673 births, according to a CDC report published on Wednesday. From 2015 to 2020, births experienced an average annual decline of 2%, with fluctuations in subsequent years.
The report also outlines the birth rates for women aged 15 to 44, known specifically as the birth rate. This rate declined between 2014 and 2020, fluctuating until 2024, where it reached 54.6 births per 1,000 individuals—an increase of 0.2% from 2023.
Brady Hamilton, the primary author of the report and a CDC statistician, noted that the data continues the ongoing downward trend in teenage births and the upward trend in births among older women observed in the past three decades. However, the CDC refrained from offering specific explanations for this trend.
An analysis of CDC data by a sociologist suggests that this trend largely reflects women delaying childbearing in their 20s and opting to do so in their 30s and 40s. Birth rates increased last year among women aged 25 to 44, while declining in teenagers and individuals under 25.
“There are various factors at play,” explained Karen Benjamin Guzzo, director of the Carolina Population Center at the University of North Carolina, Chapel Hill. These factors include considerations about partners, financial stability, job security, and overall expenses.
According to a CDC report, the average woman in 2024 had one or two biological children compared to three or more in 1960. Since 2007, overall birth rates in the US have been decreasing, with sociologists anticipating this trend to persist despite a slight increase last year.
Sarah Hayford, director of Ohio State’s Institute of Population, highlighted that economic improvements post-Great Recession have not necessarily translated into enhanced financial conditions for many individuals, impacting decisions around childbearing.
Guzzo noted that the Trump administration’s policies, including tariffs and federal programs supporting women and children, could impact the environment for childbearing decisions. The administration has expressed concerns over declining fertility rates, with Vice President JD Vance advocating for increased births in the US.
President Donald Trump himself has championed family formation, signing an executive order to expand access to in vitro fertilization. The administration is reportedly considering incentives, such as a $5,000 cash bonus after birth, to encourage more births, although experts suggest these efforts may not reverse declining fertility rates.
Sociologists opine that low fertility rates are not inherently problematic, and the decline in teenage birth rates is viewed as a positive trend. Guzzo expressed optimism that individuals today have more autonomy in deciding the right time for childbearing.
This article is part of It’s overlookedno obituaries were reported in the times about the astonishing people who died in 1851.
Katherine Dexter McCormick was born into a life of wealth that has deteriorated through marriage, but may have simply enjoyed many of the benefits that flowed in her way. Instead, she placed her considerable fortune, in line with her considerable intentionality, to make the woman’s life better.
Activist, philanthropist and benefactor McCormick strategically used her wealth. Most notably, he undertook basic research that led to the development of contraceptives in the late 1950s.
Previously, contraception in the US was very limited, with diaphragm and condoms being banned. The advent of pills made it easier for women to plan when and whether they have children, and promoted the explosive sexual revolution of the 1960s. Today, the pill is despite some side effects Most widely used A reversible form of birth control in the United States.
McCormick’s interest in birth control began in the 1910s when she learned of Margaret Sanger, a feminist leader who was imprisoned for opening the country’s first birth control clinic. She shared Sanger’s passionate belief that women should be able to diagram their biological fate.
The two met in 1917 and soon hatched an elaborate scheme for smuggling diaphragms into the United States.
Diaphragm was prohibited under the Comstock Act of 1873, resulting in a federal crime of mailing or delivering “indecent, indecent or crude” material, including pornography, birth control, and items used for abortion. (I have received laws that still prohibit mailing items related to abortions New attention (Because the federal rights to abortion were overturned in 2022)
Fluent in French and German, McCormick traveled to Europe, where the diaphragm was commonly used. She studied biology at the Massachusetts Institute of Technology and was able to possibly possibly in a meeting with the diaphragm maker. “She bought hundreds of devices and hired a local tailor to sew it on her dresses, evening dresses and coats.” Articles from 2011 MIT Technology Review. “Then she wrapped her clothes around and stuffed them neatly into the trunk for shipping.”
She and her steamer trunks passed through customs. If authorities had stopped her, they would have said, “Only the slightly fluffy dresses that own the boss’s socialites would ooze such self-importance, grandly restraining Porter and doubting nothing.”
From 1922 to 1925, McCormick smuggled over 1,000 diaphragms into Sanger’s clinic.
After her husband passed away in 1947, she took over a significant amount of money, and she asked Sanger for advice on how to put it to use birth control advances. In 1953, Sanger introduced Gregory Goodwin Pinkus and Min Chew Chan, a researcher in Worcester experimental biology in Massachusetts.
She was excited by their work and provided what she needed to provide almost all of the funding (about $23 million today). She even moved to Worcester to monitor and encourage their research. Pincus’ wife Elizabeth explained that McCormick was a warrior.
Katherine Moore Dexter was born on August 27, 1875 in Dexter, west of Detroit, to a family of wealthy social activists. The town is named after his grandfather, Samuel W. Dexter. Samuel W. Dexter founded it in 1824, maintaining an underground railway stop in the home where Catherine was born. Her great grandfather, Samuel Dexter, was the Secretary of Treasury under President John Adams.
Catherine and her brother, Samuel T. Dexter, grew up in Chicago. Their mother, Josephine (Moore) Dexter, was a Boston Brahmin who supported women’s rights. Their father, Wirt Dexter, was a powerful lawyer who served as president of the Chicago Bar Association and director of the Chicago, Burlington and Quincy Railroads. He also later led the relief committee. Amazing Chicago Fire In 1871 he was a major real estate developer.
He passed away when Catherine was 14 years old. A few years later, her brother died of meningitis while attending Harvard Law School. Those early deaths directed her into a medical career.
She attended MIT and majored in biology. A rare achievement for women of that era. She arrives with her own heart and successfully completes the rule that female students must always wear hats, claiming that they always pose a fire risk at the Institute of Science. She graduated in 1904 and was planning to attend medical school.
But by then she had begun dating the dashing Stanley Robert McCormick, whom she knew in Chicago. She knew in Chicago. As a young lawyer, he helped negotiate the merger that became his family. Main owner of International HarvesterBy 1909 it was America’s fourth largest industrial company and was measured by assets.
McCormick persuades Katherine to marry him instead of going to medical school. They married at their Swiss mother Chateau and settled in Brookline, Massachusetts.
However, even before they got married, he showed signs of mental instability, so he began to experience violent and delusional delusions. He was later admitted to hospital with what was later determined to be schizophrenia and remained under psychiatric care – almost Riven Rock, Until his death, McCormick Family Estate in Montecito, California. She never divorced him and never remarried. They had no children.
Katherine McCormick spent decades in personal, medical and legal disputes with her husband’s siblings. They fought about his treatment, his protection, and ultimately his property, Prologue Magazine’s 2007 articlePublications of the National Archives. She is his sole beneficiary, inheriting about $40 million ($563 million in today’s dollars). She combined with the $10 million inherited from her mother (more than $222 million today) made her one of America’s wealthiest women.
As her husband’s illness consumed her personal life, McCormick threw herself into social causes. She contributed financially to the suffrage movement, gave speeches, demonstrated leadership and demonstrated leadership to become treasurer and vice president. National Women’s Suffrage Association. After women gained the right to vote in 1920, the association evolved into a federation of women’s voters. McCormick has become vice president.
In 1927 she founded the Neuroendocrine Research Foundation at Harvard Medical School. She provided funding for 20 years, gaining expertise in endocrinology, and later conveyed her interest in the development of oral contraceptives.
After the FDA approved the pill, McCormick turned his attention to funding the first on-campus residence for women at MIT when he studied there. The women did not have a home. “If we can properly accommodate them, the best science education in our country will be open forever,” she said.
Named after her husband, McCormick Hall opened in 1963 on the Institute’s Cambridge campus. At the time, women accounted for about 3% of the school’s undergraduate students. Today they make up about 50%.
By the time she died of a stroke at her Boston home on December 28, 1967, McCormick was playing a major role in expanding opportunities for women in the 20th century. She was 92 years old.
Apart from the short Boston Globe article, she barely noticed her death. The later obituaries of birth control researchers she supported did not mention her role in their achievements.
At her will, she left $5 million in the planned Parent-Child Relations Federation (more than $46 million today) and $1 million in the Pincus Institute (more than $9 million today). Previously, she had donated Swiss successive property to the US government for use by diplomatic missions in Geneva. She left most of the rest of her property
The US has ended financial support for family planning programs in developing countries, separating nearly 50 million women from access to birth control.
This policy change has attracted little attention in the wholesale demolition of US foreign aid, but it has great significance, including mother deaths and an overall increase in poverty. It derails the efforts that have in recent years brought long-acting birth control pills to some of the world’s poorest and most isolated regions.
The US contributed to family planning programs in 31 developing countries last year, providing about $600 million in 2023, according to the health research institute KFF.
According to an analysis by the sexual health research institute, the US funding provides birth control pills and medical services to deliver them to more than 47 million women and couples, reaching over 47 million women and couples. Without this annual contribution, 34,000 women could die from preventable mother deaths each year, Guttmacher’s calculation concluded.
“The magnitude of the impact is daunting,” said Mariva, who leads the coordination team for the Ouagadougou Partnership, an initiative to accelerate access to investment and family planning in nine West African countries.
The funding ended as part of the Trump administration’s breakdown of the US International Development Agency. The State Department, whose USAID skeletal remains were absorbed on Friday, did not reply to a request for comment on its decision to cease funding for family planning. Secretary of State Marco Rubio explains that he wasted the fired aid project and is not in line with America’s strategic interests.
Supporting family planning in the world’s poorest and most populous countries has been a consistent policy priority for both Democrats and Republican administrations for decades, considered a breakwater against political instability. It also reduced the number of women seeking abortions.
Among the countries that will be heavily affected by the decision are Afghanistan, Ethiopia, Bangladesh, Yemen and the Democratic Republic of the Congo.
Funds to support the International Family Planning Program have been allocated by Congress and have been extended to the latest expenditure bill, which the government is operating until September. Moves by the State Department to cut these and other aid programs are now the subject of multiple lawsuits before federal courts.
The Trump administration has also fired US funding for UNFPA, the UN’s sexual reproductive health organization, the world’s largest procurement of birth control pills. The United States was the organization’s largest donor.
The US was not the sole supplier of birth control in any country, but the sudden termination of US fundraising has created disruption to the system and has already run out of products in clinics.
The estimated $27 million worth of family planning products already raised by USAID are stuck at various points in boats, ports and warehouses. Programs and employees have no programs or employees left to take them down or hand them over to the government. One plan proposed by Washington’s new USAID leadership is for the rest of the employees to destroy them.
Supply chain management is a major focus for USAID in all areas of health, with the US paying for transporting contraceptive products such as hormone implants, for example, from Thai manufacturers to ports in Mombasa, Kenya.
“It will be extremely difficult to put your work back on,” said Dr. Natalia Kanem, executive director of UNFPA.
The US has also paid for data and information systems that help the government track what is in stock and what needs to be ordered. None of these systems have been working since the Trump administration sent halt work orders to all programs that received the USAID grant.
Bellington Wwalika, a professor of obstetrics and gynecology at the University of Zambia, said contraceptives have already begun running in some parts of the country, with the US supplying a quarter of the national family planning budget.
“Wealthy people can buy the products they want. It is the poor who have to think, ‘What should I get between food and birth control?'” he said.
Even before the US retracted its family planning program, the survey found that globally, 1 billion women of reproductive age wanted to avoid pregnancy, but modern methods of birth control were inaccessible.
At the same time, there have been great progress. Demand for contraception is steadily increasing in Africa, a region of the world with lowest coverage, in long-acting ways that provide women with greater privacy and safe protection. Supply has been improved with better infrastructure and helped deliver products to rural areas. And the “Demand Creation” project, which is the main funder in the US, used ads and social media to inform people of the various options available and the benefits of pregnancy intervals or delays. The rise in education levels among women has also increased demand.
Two weeks ago, Thermasibanda, a 27-year-old engineering graduate who lives in a low-income community on the edge of Zimbabwe’s capital, Harare, received a hormone implant that prevents pregnancy for five years.
Shibanda has a two-year-old son and says he can’t afford more children. She can’t find a job in Zimbabwe’s broken economy and her husband can’t. They follow the $150 presence he earns from the vegetable stand every month. She relied on “hope, faith and natural methods” to prevent another pregnancy from happening after her son was born, Shibanda said, hoping for something more reliable, but that was simply impossible on her family’s budget – until a free clinic came to her neighborhood.
With USAID funding, the Zimbabwean organization that provided implants last year has been able to purchase six robust Toyota vehicles and camping equipment so that outreach teams can travel to the country’s most remote parts and provide vascular removal and IUD at pop-up clinics. Since Trump’s executive order, they have had to stop using all of that equipment.
International nonprofit MSI reproductive options intervened with temporary funds to ensure that they could continue to provide free care to women they could reach, such as Shibanda.
Shibanda said her priorities are to provide her son with the best possible education and that there are no more children as tuition costs. However, many African women have no way of making this choice. In Uganda, the national fertility rate is 4.5 children per woman, but it is not uncommon to meet women in rural areas with limited education with eight or 10 children, said Dr Justin Bukenya, lecturer in community health and behavioral sciences at Makerele University in Kampala. These women become pregnant for the first time as teenagers, with little space between pregnancy.
“By the time they were 30, they were able to get their 10th pregnancy. These are the women affected,” she said. “We’re missing the opportunity to make progress with them. The United States was doing a very strong job of creating the demands of birth control with these women here and mobilizing young men and women to go to family planning.”
Some women who rely on free or low-cost services through the public health system may now seek to buy birth control pills in the private market. However, the prices of tablets, IUDs and other devices are likely to rise significantly without guaranteed to buy large quantities from the US.
“As a result, women who relied on free or affordable options through the public health system could now be forced to rely on private sector sources.
The next biggest donor to post-US family planning is the Netherlands, which provided about 17% of donor government funding in 2023, and the UK provided 13%. The two countries recently announced plans to cut their aid budget by more than a third.
BA said the focus of the West African countries she works for is to mobilize domestic resources and come up with ways for governments to try and relocate money to cover what the US supplies. Charities such as the Gates Foundation and financial institutions, including the World Bank, which are already important contributors to family planning, could provide additional funding to try to move products into the country.
“We were very optimistic. Even with all the political instability in our area, we’ve been using modern methods to add millions of women over the last few years,” BA said. “And now, it’s all, US support, policy, it’s all gone completely. The gap is too big to fill.”
More than a quarter of the world’s women, which is over one billion women, are in need of contraception, as reported by a 2021 global organization report. Source.
Thankfully, there are numerous options available for women seeking contraception. With over 13 different methods of birth control and more than 200 different brands of birth control pills worldwide, women have a variety of choices. The majority of birth control methods in use today are hormonal, including birth control pills, implants, and intrauterine devices.
Women use contraception for various reasons beyond preventing pregnancy. Some reasons include managing painful or heavy periods, irregular periods, and acne.
Each woman’s contraceptive needs are unique, and variables such as ethnicity, postpartum status, menopausal stage, or other medications can further complicate the selection process.
On average, women try 3.4 different contraceptive methods during their lifetime, according to a US study. Study reference.
The most common issue faced by women using hormonal contraceptives is the side effects, which can be severe and lead to discontinuation of the pills. Side effects may include migraines, blood clots, irregular bleeding, nausea, and mood changes.
Choosing the right birth control method can take years due to the changing hormonal states in a woman’s body throughout life stages. Personalized medicine could provide a solution by customizing contraceptives to individual needs based on genetics and other factors.
read more:
In a groundbreaking study, researchers at the Yale School of Medicine identified genetic variations that affect the efficacy and side effects of hormonal contraception. Genetic mutations, such as the CYP3A7 gene mutation, can impact the metabolism of contraceptive hormones, leading to contraceptive failure in some women.
Another study by the same research team found that genetic mutations in the ESR1 gene may contribute to weight gain associated with using contraceptive implants.
Understanding these genetic factors could pave the way for personalized medicine in women’s health, reducing side effects and enhancing satisfaction with contraception.
Further research and large-scale studies are needed to unlock the full potential of personalized medicine in women’s health and ensure optimal healthcare delivery to women.
A new study led by Western Washington University suggests that sister city relationships have been around for longer than we thought.
Jack H. McBride and Tesla A. Monson conducted a comprehensive study of primate offspring numbers using life history data from 155 primate species and offspring numbers from an additional 791 mammal species. Image by Jason Brougham.
“Nearly all primates give birth to a single litter,” say Tesla Monson, a professor at Western Washington University, and Jack McBride, a doctoral student at Yale University.
“However, some genera, such as marmosets, tamarins, lemurs, lorises, and galagos, regularly give birth to twins or triplets.”
“Although humans most often give birth to singletons, twin pregnancies occur naturally at a rate of approximately 1.1-1.5% worldwide.”
“Advances in assisted reproductive technology have increased twin birth rates to around 3% in some areas over the past 50 years.”
“There is an urgent need to understand the impact of twins on pregnancy, mothers, and newborns.”
In this study, the authors collected data on reproduction and body size from nearly 1,000 different mammalian species to investigate the evolutionary history of twinning in primates.
The traits they analyzed included offspring size (number of offspring), gestation period, body size, and lifespan.
Contrary to previous assumptions, the analysis demonstrates that the earliest primates likely gave birth to twins.
The researchers also found that birth size and gestational age (the length of pregnancy) were closely related.
“Animals that give birth to more pups on average tend to have shorter gestation periods,” Professor Monson said.
“This also applies to humans. In the United States, full-term twins are considered to be born at 38 weeks, not 40 weeks, and many twins are born earlier than that.”
“This may be related to maternal energy limitations.”
“The next step is to look more broadly at offspring number across mammals and see which other reproductive, brain, and body size traits are associated with twinning.”
“We are particularly interested in understanding the relationship between twinning and tooth morphology.”
Scientists used fitness tracker WHOOP to monitor heart rate during pregnancy
Oops
Wearing a wrist-strap heart rate tracker during pregnancy may help doctors predict who is at risk for premature birth.
In previous research, shon rowan Researchers at West Virginia University recruited 18 women to wear heart-tracking wrist straps from the brand WHOOP throughout their pregnancies.
They were all born at term, and tracking data showed that heart rate variability (the variation in the time interval between heartbeats) decreased clearly during the first 33 weeks of pregnancy, and then steadily increased until birth. It became clear.
Rowan was curious to see if the same pattern occurred in people who give birth prematurely. Emily Capodilupo A larger study is being conducted at WHOOP in Boston, Massachusetts. They and colleagues analyzed tracker data provided by 241 pregnant women between the ages of 23 and 47 in the United States and 15 other countries. It is unclear whether this data includes data for transgender men.
All participants were pregnant with one child born between March 2021 and October 2022. In total, more than 24,000 heart rate variability records were provided.
Similar to the previous study, those who gave birth at term showed an obvious switch in heart rate variability around 33 weeks of gestation, or an average of seven weeks before delivery.
However, the 8.7% who were born prematurely had much less consistent patterns of heart rate variability, Rowan said. This change from decrease to increase in variability occurred at different times during pregnancy, but similar to those born at term, the change occurred on average about 7 weeks before birth, although the birth was premature. It seemed like there was.
In the future, the device could identify pregnancies that require closer monitoring or benefit from administering drugs such as steroids to help the fetus' lungs develop, Rowan said.
You can also plan to stay near hospitals that provide specialized care, which can be especially helpful for people who live in remote areas, he says.
“Once we are able to remotely monitor some of their health using things like the WHOOP tracker, and we start to see changes in that. [in heart rate variability]Then you might be able to be a little more proactive,” says Rowan.
Its mauve, suction cup-covered arms gently unfold to grab an egg shaped like an elongated ping-pong ball. A jet of water from a siphon next to the octopus's head ensures that the unhatched cubs get enough oxygen.
From a distance, she is surrounded by hundreds of females, living up to her nickname. The pearl octopus (Muusoctopus robotus) resembles a spherical gem that sits on the ocean floor. This is the largest known assemblage of eight-armed molluscs on Earth, numbering approximately 20,000 individuals, and has been witnessed by people all over the world in astonishingly high resolution. “Oceans” episode BBC series Planet Earth III.
This view would have been amazing enough even if it were from shallow water, including tropical coral reefs and kelp forests. But these octopus mothers tend to their eggs in freezing cold and darkness, about 2 miles below the surface. of the deep sea.
“The fact that there is life there is amazing in itself,” says the producer and director. Will Ridgeon They spent two years photographing the octopus, collaborating with scientists and technicians at California's Monterey Bay Aquarium Research Institute (MBARI).
The aptly named pearl octopus rears its eggs in an octopus garden surrounded by flower-like anemones. – Credit: Monterey Bay Aquarium Research Institute
The octopus farm, as the site is now known, is located on a hill in the eastern Pacific Ocean, 160 km (100 miles) southwest of Monterey Bay, near a giant underwater mountain called Davidson Seamount. This place was discovered during his expedition in 2018. live streamed over the internet.
It was the first time I had ever seen so many creatures in one place, let alone in the deep sea. (Octopuses are notoriously solitary animals and tend to be cannibalistic when kept together in captivity.) ).
Ridgeon watched the livestream of the discovery and immediately knew it was a story to be filmed in a new BBC series.he teamed up with Dr. Jim Barrya senior scientist at MBARI, began regularly visiting octopus farms in 2019 to learn more about why so many octopuses congregate in certain areas.
“The question is, why is it there?” Barry says. Barry and his colleagues gathered specialized tools and began a series of detailed studies. They created a photomosaic of his 2.5-hectare (about 27,000 square feet2) portion of the property and stitched together high-resolution images that allowed them to count the octopus population.
They also installed time-lapse cameras on the ocean floor, taking close-up photos every 20 minutes at a time for months to show what the octopuses were doing, and Barry's team gradually expanded the octopus park's largest began to unravel some of the mysteries.
Octopus farm location. – Image credit: MBARI
work remotely
Ridgeon took part in an expedition to an octopus farm early on. Initially, filming took place during lockdown, so he participated via live video link from his bedroom in Bristol, England (with occasional interruptions from his five-year-old daughter).
Once COVID-19 restrictions allowed, Ridgeon joined Barry and his team aboard MBARI's vessel, the research vessel Western Flyer. However, no one visited the octopus farm directly. All surveys and filming were done using a car-sized remotely operated vehicle (ROV) equipped with a camera and a robotic arm.
The dive began around 6 a.m., and the ROV was lowered into the ocean through a hole in the Western Flyer's hull called the moonpool. “It's very James Bond,” Ridgeon says. The descent to the octopus garden can take up to two hours, and the ROV will remain there all day.
The pilot controls the ROV via a cable connected to a control room on the ship on the ground, and everyone watches the video feed to see what's happening below.
Researchers survey the octopus farm from the Western Flyer's ROV control room. – Credit: Monterey Bay Aquarium Research Institute
“You forget you're looking at a screen,” Ridgeon says. “You think you're there,” says the MBARI engineer. He worked with the BBC to find the ideal camera setup to photograph the octopus garden. It was not possible to use footage from a camera fixed to the ROV due to too much vibration.
“I think the BBC will do a little bit about that.” [shivering]“But not as much as we had,” Barry says. ROVs “shudder” not because of the cold temperatures of the deep ocean, but because the thrusters must be activated constantly to ensure they stay close to the ocean floor (ROVs are positively buoyant, so if they fail they will ). .
To get around this, Barry and Ridgeon used a separate 4K camera mounted on a specially designed stand that could be placed on the ocean floor.
“I think that's the secret behind the images,” Ridgeon says. Unlike the ROV cameras used by scientists, which can only reach within a few meters of objects on the ocean floor, the 4K camera's focal length of about 20 centimeters (7 to 8 inches) allows it to precisely navigate between octopuses. can be captured.
But it was difficult to use. It took up to 40 minutes to get into position, and the team had to hope it wouldn't fall over and the action would happen in front of it. Ridgeon operated the camera from the ship using his PlayStation controller, which MBARI engineers adapted for the job. “At first it's like trying to film him with his hands tied behind his back,” Ridgeon said.
Another challenge with deep-sea photography is light. “Put the light as far away from the camera as possible, ideally around the sides so it’s three-quarters backlit. [the scene]That way, there are no reflections from any debris in the water,” explains Ridgeon.
The octopus garden provides insight into the life and reproduction of molluscs. – Credit: Monterey Bay Aquarium Research Institute
Those “fragments” are marine snow. These are organic particles that constantly rain down from the shallow ocean above. Marine snow is made up of dead plankton and their feces stuck together by microbial glue, and is the main food source for deep-sea animals. However, it makes filming difficult as the movie can look like it was shot in a snowstorm.
To see through the snowstorm and achieve the desired three-quarters backlighting effect, the MBARI team built a lighting system that the ROV could hold on its side, away from the camera. “That's how we got some really great shots,” Barry says.
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Accelerate development
As Barry's investigation and BBC filming progressed, the team made some surprising discoveries. First, no medium-sized octopus ever visited this location, and there were no signs of it feeding. It was only a fully grown adult octopus.
They were here to breed and for no other purpose. It may be called an octopus farm, but this place is definitely an octopus farm. The researchers also collected evidence that incubating females use on-site hot springs to speed up the development of their offspring.
For octopuses, there is a strong relationship between temperature and hatching time. The colder it is, the longer it will take and the more dangerous it will be. This is because there are scavengers that prey on unborn, unprotected octopus eggs.
Temperature studies have shown that the seawater surrounding each octopus nest can reach 10°C (50°F), much warmer than the 1.6°C (34°F) seawater just a few meters away. It was shown. By observing specific octopuses (identifiable by scratch and scar patterns) in the field, Barry and his colleagues determined that their eggs take an average of 1.8 years to hatch.
During this time, the female does not move but is constantly fighting off predators and guarding her approximately 60 eggs. “Once you plant an egg on a rock, that's it. You can't leave that spot,” Barry says. At just under two years, it's not the longest parenting period for an octopus. This record is given to another species that other MBARI scientists discovered nearby, Graneledon boreopafica, clinging to the sides of Monterey She Canyon 1.4 km (just under a mile) deep. I did.
Researchers watched one female incubate her eggs for four and a half years, longer than any other recorded animal. However, she was growing her eggs in water that was much warmer than the octopus park's ambient temperature of 1.6 degrees Celsius. Without the hot springs, the eggs in the octopus garden would take more than 10 years to hatch. When this site was discovered, biologists were surprised to find octopuses nesting there.
But geologists were fascinated by warm water seeping through the ocean floor, something they had never seen before. These springs are much cooler than the red-hot hydrothermal vents that form at the edges of tectonic plates where new molten ocean floors are created.
Although the enormous pressure will not cause the water to boil, the temperature around the vent can reach hundreds of degrees. These were first discovered in his 1970s, and plumes of hydrothermal water rise up to hundreds of meters in the water column, making them relatively easy to detect with temperature probes. In contrast, hot springs are more difficult to find because they form away from these tectonically active regions and have much cooler temperatures.
But geologists believe they could exist in the thousands and are highly stable, likely remaining in the same location for hundreds or even thousands of years. Therefore, biologists believe that more octopus farms may be established around these springs.
birth and death
In the final scene of the “Octopus Garden” episode Planet Earth III, a cluster of tiny sucker-like arms appears beneath the brooding female, then a wobbling young octopus swims away into the darkness like a mini-umbrella. More chicks follow and begin life at sea.
No one knows where they're going…yet. “That's what I want to understand next,” Barry says. The hatchlings are large for a newborn octopus, at about 6 cm (2 inches), so they have the best chance of survival. But as anyone who has seen the Octopus documentary knows, this comes at a heavy cost to mothers.
“These mothers are trying so hard to protect their bloodlines, and they're just dying out,” Barry says. Her father died a few years ago, shortly after mating. On the screen, we see the women's eyes cloudy and their bodies wrinkled. Ridgeon saw what happened next, but she decided it was not suitable for an evening television audience.
Dead octopuses are quickly attacked by scavengers such as fish, snails, sea anemones, and shrimp. For Barry, this is another important part of his discovery at the octopus farm. The nesting season is asynchronous, with octopuses hatching and mothers dying throughout the year. Approximately 9 each day. The female octopus' body nourishes the rest of the ecosystem and helps supplement the energy input from marine snow by 72 percent.
Graneledon boreopafica (a species of octopus that incubates eggs in cold water) has a 4.5 year rearing period, which holds the record for the longest rearing period of any animal. – Credit: Alamy
“This is clearly a huge food subsidy for the local ecosystem,” Barry says. “That wouldn't happen in shallow water,” he added. Because there is a lot of food around. But in the more barren depths, nothing goes to waste.
The BBC has finished filming at the octopus farm, but Barry's research continues. One of the things he wants to know is the age of the sea anemone. These are giant orange flower-like animals that make the octopus garden look like a real garden.
Barry studies sea anemones, which live for decades in shallow coastal waters, and finds that deep-sea species can survive for centuries, in contrast to octopuses, which are relatively short-lived. That's what I'm thinking.
“They're like sentinels that just sit there while the octopus cycles,” he says. There are many more questions Barry would like to answer. “Are octopuses confined to this breeding form in warm areas, or are they able to breed elsewhere with cooler ambient temperatures? Is there fidelity to specific nest sites? ?Will they return to their place of birth?'' he asks.
No one knows how far the octopuses travel before they reach the garden or how they found them, but Barry said he was surprised by the large number of dead and dying octopuses floating around. I suspect I smelled it. “We'll definitely be back,” he says.
A new study has found that women using NSAIDs with hormonal contraceptives, especially high-risk types and those using diclofenac, have an increased risk of blood clots. This study calls for increased awareness and careful consideration of safer pain relief and contraceptive options.
Researchers advise that while the absolute risk remains low, women should be informed accordingly.
People using nonsteroidal anti-inflammatory painkillers in combination with hormonal contraceptives may be at a slightly higher risk of venous thromboembolism (VTE), according to a recently published comprehensive Danish study. There is a gender. BMJ.
The risk was higher for women using combination oral contraceptives containing third- or fourth-generation progestins, but the nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen, diclofenac, and progestin-only tablets; Women with implants and coils had a smaller risk. Naproxen.
Researchers stress that the absolute risk of developing serious blood clots is low, even for women using high-risk hormonal contraceptive methods. However, they say that given the widespread use of both hormonal contraceptives and NSAIDs, women should be informed of this potential drug interaction in a timely manner.
Classification of hormonal contraception and NSAID use
Although NSAIDs have been linked to blood clots, little is known about whether their use affects the risk of venous thromboembolism in healthy women using hormonal contraceptives. not.
To address this, the researchers used national medical records to find 49 children aged 15 to 49 with no history of blood clots, cancer, hysterectomy, or infertility treatment living in Denmark between 1996 and 2017. Two million women aged 20-30 years were tracked for their first diagnosis of venous thromboembolism.
Hormonal contraception was classified as high-risk, intermediate-risk, and low-risk according to its association with VTE based on previous studies.
High-risk hormonal contraception includes patches that combine estrogen and progestin, vaginal rings, and tablets containing 50 mcg of estrogen or third- or fourth-generation progestins. Moderate-risk contraception includes all other combination oral contraceptives and medroxyprogesterone injections, but progestin-only pills, implants, and hormonal intrauterine devices (coils) are classified as low-risk or no risk. I did.
Various potentially influencing factors were also taken into account, including age, education level, pregnancy history, previous surgical history, hypertension, and diabetes.
In this study, 529,704 women using hormonal contraceptives used NSAIDs. The most frequently used NSAID was ibuprofen (60%), followed by diclofenac (20%) and naproxen (6%).
Over an average 10-year monitoring period, 8,710 cases of venous thromboembolism (2,715 pulmonary embolisms and 5,995 deep vein thromboses) occurred, and 228 (2.6%) women died within 30 days of diagnosis.
Meaning and recommendations
In absolute terms, NSAID use is associated with 4 additional venous thromboembolic events per week per 100,000 women not using hormonal contraception and using intermediate-risk hormonal contraception. It was associated with 11 additional events in women and 23 additional events in women using high-risk hormonal contraception.
Among individual NSAIDs, diclofenac had the strongest association compared with ibuprofen and naproxen.
Because this is an observational study, it is not possible to determine cause, and the researchers highlight several limitations, such as missing information on smoking and obesity, which may influence the results. It is said that there is a possibility that
Nevertheless, this was a large study based on high-quality registry data, allowing the researchers to adjust for a wide range of potentially influencing factors. Furthermore, the associations persisted after further analysis, suggesting that they are robust.
Therefore, the researchers concluded that: “By using high-quality, linkable national registries, this national study shows that potentially fatal events occur when two drugs commonly prescribed to healthy women are taken together. It adds new knowledge about the risks involved.”
They added: “Women who require both hormonal contraception and regular use of NSAIDs should be advised accordingly.”
These data raise important concerns about the combined use of NSAIDs, particularly diclofenac, and high-risk hormonal contraceptives, writes Morten Schmidt. Aarhus University Hospital, linked editorial.
She said health authorities and regulators should include these findings in safety assessments of over-the-counter diclofenac, and that women using hormonal contraceptives and their clinicians should consider alternatives to NSAIDs for pain relief. I suggest that you should.
“If treatment with an NSAID is necessary, it may be preferable to use drugs other than diclofenac in conjunction with low-risk hormonal contraceptives, such as progestin-only tablets, implants, or intrauterine devices.” He concludes.
This study was funded by the Danish Heart Foundation.
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