Study suggests that high consumption of fruit may lower risk of depression

A new study led by scientists at the University of New South Wales confirms that eating fruit can help ward off depression – but eating vegetables does not.

High fruit intake is associated with a reduced risk of developing depression.

Depression is a major public health concern: the global impact of depressive disorders is estimated to be over 50 million years of life lived with disability, making depression the largest contributor to non-fatal disease burden.

More than 80% of this burden is borne by low- and middle-income countries.

Compared with depression in younger adults, depression in older adults has a greater impact on physical and cognitive abilities and is associated with reduced quality of life and increased all-cause mortality.

A growing body of evidence suggests that diet, particularly increasing fruit and vegetable intake, may be important in reducing the risk of depression.

“The aim of this new study was to examine the relationship between fruit and vegetable consumption and depression in adults aged 45 and over,” said researcher Dr Annabel Mattison, from the University of New South Wales.

The study involved 7,801 non-depressed, community-dwelling adults from multiple sites across six continents, including the United States, Sweden, Brazil, Nigeria, Malaysia and Australia.

The results showed a beneficial association between higher fruit intake and a lower risk of depression over a nine-year period.

“This intriguing finding of a protective relationship between fruit consumption and risk of depression points to the need for greater emphasis on diet in healthcare,” said Dr Mattison.

The results suggested a benefit to vegetable consumption, but the benefit was not statistically significant.

“The reason we found a beneficial association with fruit consumption but not with vegetable consumption may be because fruits are typically consumed raw, whereas vegetables are typically consumed cooked, which may affect their nutritional value,” Dr Mattison said.

“Fruit and vegetable intake was self-reported via a comprehensive food frequency questionnaire, a short food questionnaire, or a dietary history.”

“Depressive symptoms were assessed using validated scales, and depression was defined by applying validated cut-offs.”

“We used Cox regression to examine the association between baseline fruit and vegetable intake and incident depression over 3- to 9-year follow-up periods.”

It has been suggested that the high antioxidant, dietary fiber, and vitamin content of fruits and vegetables may have beneficial effects on depression through a variety of mechanisms, including their role in inflammation, oxidative stress, and gut microbiota.

Because fruits and vegetables contain different nutrients, it is also possible that different types of fruits and vegetables may have different effects on depression risk.

The evidence that citrus fruits and green leafy vegetables reduce the risk of depression is particularly strong.

“Future studies that take into account consumption of different types of fruit and vegetables using standardized measures and focus on a larger number of older people, particularly in low- and middle-income countries, are definitely needed,” Professor Henry Brodaty, from the University of New South Wales, said.

“The expanding research currently being conducted into genes associated with dietary intake provides a promising avenue for influencing fruit and vegetable intake.”

“To better understand the association, the types of fruits and vegetables consumed also need to be taken into account, and studies need to be designed to be more comparable across cohorts.”

of study Published in Journal of Affective Disorders.

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Annabelle P. Mathison others2024. Associations between fruit and vegetable intake and incident depression in middle-aged and older adults in 10 diverse international longitudinal cohorts. Journal of Affective Disorders 359: 373-381; doi: 10.1016/j.jad.2024.05.096

Source: www.sci.news

Wax Heads: A Videogame Bringing High Fidelity to Life in a Record Store

pictureEvery time I experience a breakup, I am drawn to revisit the 2000s classic, High Fidelity. The film follows John Cusack’s character as he nostalgically lists the top 10 worst breakups in his life, each accompanied by a fitting soundtrack. Rather than focusing on Cusack’s glamorous ex-partners, the film revolves around his record store, Championship Vinyl, a haven for lost souls in Chicago.

This DIY community spirit is echoed in Wax Heads, a narrative game centered around running a struggling record store. Described as a “cozy punk life sim,” the game captures the essence of High Fidelity as players navigate the chaos of their first shift at Repeater Records, a fictional store.




Geek mecca…John Cusack, Jack Black, Todd Louiso, and Tim Robbins in High Fidelity. Photo: Getty Images

Unlike traditional business sims, Wax Heads focuses on the joy of selling records rather than the mechanics of running a store. The game celebrates the local record store as a vibrant community hub, where music enthusiasts can connect and discover new sounds.

Murray Summerwolf, co-creator of Wax Heads, explains that the game revolves around the idea of a record store as a place of connection and community. Players engage with quirky characters, explore music recommendations, and immerse themselves in the everyday life of a record store.

The gameplay mirrors traditional point-and-click adventures, putting players in the role of a retail clerk and music detective. By deciphering clues and interacting with customers, players curate the perfect album recommendations, earning points based on customer satisfaction.




Crate digger…waxhead. Photo: Patati Games

Wax Heads is a refreshing take on music games, focusing on the cultural experience of music rather than pure gameplay mechanics. The game explores themes of community, empathy, and human connection through the lens of a record store.

Source: www.theguardian.com

Forecasts Predict a High Number of Storms for Hurricane Season

Initial predictions for the upcoming Atlantic hurricane season indicate that it could be particularly severe and potentially break records.

Colorado State University, a renowned center for hurricane and tropical weather forecasting, has released forecasts stating that there could be 11 hurricanes, with five of them potentially reaching Category 3, 4, or 5 status, which means wind speeds of at least 111 mph. In total, researchers anticipate 23 named storms for this season.

“This is the most accurate forecast we’ve made for April,” stated Colorado meteorologist and Atlantic hurricane forecaster Philip Klotzbach during a video news conference.

On average, an Atlantic hurricane season typically sees 14 named storms, seven hurricanes, and three major hurricanes (Category 3 or higher), according to the National Hurricane Center.

The primary reasons for the above-average expectations for the upcoming season (June 1 to November 30) are the unprecedented levels of warmth in the Atlantic Ocean and the natural fluctuations caused by La Niña. Ocean temperatures have hit record highs in the past year, enhancing the probability of potent storms and potentially intensifying them at a faster rate.

According to Colorado’s forecast, there is a 62% likelihood of a major hurricane striking the U.S. coastline, an increase of about 19% from the norm. However, this projection was disclosed earlier this year and will be updated as the season progresses. The National Oceanic and Atmospheric Administration has yet to release its forecast.

Other hurricane experts also express concerns about the combination of unnatural ocean warming and La Niña’s natural impacts.

“All signs point towards what could potentially be a highly active hurricane season in 2024, with very powerful hurricanes. That’s definitely something to be worried about,” remarked meteorologist and hurricane expert John Morales from NBC 6 South Florida.

Sea surface temperatures are climbing globally, setting new daily records for over a year. This trend has baffled marine scientists and is likely influenced by climate change. Some of the most significant temperature anomalies have been observed in the waters off the west coast of Africa, where many Atlantic hurricanes that hit the U.S. East Coast originate.

“The ocean heat content in the tropical eastern Atlantic is currently *3 months* ahead of the norm,” noted Brian McNoldy, a senior research scientist at the University of Miami’s Rosenstiel School of Ocean, Atmospheric, and Earth Sciences, in a tweet. In simpler terms, the ocean’s current heat levels resemble those of a typical July.

Ocean heat serves as fuel for extreme storms. If a hurricane’s winds intensify suddenly as it nears the coast, there is a heightened risk of rapid intensification. In recent years, there has been an observed uptick in such intensification. Last year, Hurricane Idalia rapidly strengthened from a Category 1 to a Category 4 storm within 24 hours.

Morales expressed that this swift intensification is “one of the greatest concerns I’ve had to keep to myself over the past 15, 20 years as a hurricane forecaster.”

“Eventually, we’ll witness a mundane tropical storm transform into a Category 4 hurricane by the time it makes landfall in Miami 36 hours later,” he warned. “And individuals may not have made the essential preparations.”

Source: www.nbcnews.com

High potency cannabis increases the likelihood of developing cannabis-induced psychosis

Anders Gillian was only 17 years old when he started to lose touch with reality.

“He believed there was a higher being communicating with him, telling him what to do and who he was,” said his mother, Christine Gillian, who lives in Nashville. ‘ he said.

Her son, who had been using marijuana since he was 14, was diagnosed with schizophrenia, a chronic mental illness with symptoms such as delusions, hallucinations, and incoherent speech.

He began taking antipsychotic medication but eventually stopped due to side effects. He turned to heroin to quiet the voices in his head and tragically died from an accidental drug overdose at age 22 in 2019.

“If he hadn’t started using marijuana, he might still be here today,” says Gillian, a neuroscientist at Vanderbilt University. Despite having a family history of schizophrenia, she believes her son’s marijuana use triggered a psychotic episode and led to his condition.

Anders was part of a group of young men at heightened risk of developing psychosis due to marijuana use. Studies from Denmark and Britain suggest a connection between heavy marijuana use and mental disorders like depression, bipolar disorder, and schizophrenia. Researchers believe that the increased potency of THC, the psychoactive compound in marijuana, may exacerbate these symptoms in individuals predisposed genetically. THC levels in marijuana have been rising over the years.

Kristen Gilliland holds a photo of her son Anders, who was diagnosed with schizophrenia due to marijuana-induced psychosis and died of an accidental overdose.NBC News

“We’re seeing a rise in marijuana-induced psychosis among teenagers,” said Dr. Christian Thurstone, an addiction expert and child psychiatrist at the University of Colorado School of Medicine in Denver.

Is higher potency marijuana more dangerous?

Nora Borkow, director of the National Institute on Drug Abuse, stated that the higher the potency of a cannabis product, the more negative effects it is likely to have on users.

“Those who consume higher doses are at a greater risk of developing psychosis,” she explained.

Research on the adverse effects of high THC levels is limited, but a 2020 study found that high-potency cannabis products were associated with an increased risk of hallucinations and delusions compared to lower-potency variants.

“There seems to be a correlation between potency and the risk of psychosis, but further research is needed,” said Ziva Cooper, director of UCLA’s Center for Cannabis and Cannabinoids.

Research suggests that a proportion of individuals with cannabis-induced psychosis may go on to develop schizophrenia or bipolar disorder.

Mr. Thurstone highlighted the particular concern regarding young people and adolescents.

“Current research shows that the risk of psychosis is dependent on the dose of marijuana, especially during adolescence. Higher exposure during this critical period increases the likelihood of psychosis, schizophrenia, and potentially severe mental illnesses,” he stated.

More news about marijuana and health

Another issue with high-potency products is the risk of developing cannabis use disorder or marijuana addiction. Increased exposure to stronger cannabis products may lead to addiction, although more research is required to definitively establish this connection.

“There is clear scientific evidence that marijuana can be psychologically addictive and habit-forming, and even physically habit-forming,” Thurstone warned. “It creates tolerance, requiring increased usage for the same effect.”

Approximately 1 in 10 individuals who start using cannabis may become addicted. According to the Centers for Disease Control.

How the potency of cannabis is related to psychosis

Marijuana overstimulates cannabinoid receptors in the brain, leading to a high. This stimulation can impair cognitive functions, memory, and problem-solving abilities.

While the exact mechanisms of how marijuana induces psychosis are not fully understood, scientists believe it interferes with the brain’s ability to differentiate between internal thoughts and external reality.

“In the ’60s, ’70s, ’80s, and early ’90s, marijuana had THC content of about 2% to 3%,” noted Thurstone, highlighting the significant increase in potency levels in recent years.

Patrick Johnson, an assistant store manager at Frost Exotic Dispensary in Colorado, has witnessed the rise in potency firsthand, especially after the legalization of recreational marijuana in 2014.

Since then, 24 states, two territories, and Washington, D.C., have legalized marijuana for medical and recreational use.

As cannabis consumption grows across the nation, the demand for high-potency products is increasing, experts suggest.

“After legalization, I’ve seen potency rise from 19-20% to 30-35%,” Johnson remarked.

Currently, his store offers strains ranging from 14% to 30%, with most customers preferring stronger varieties.

Mahmoud Elsohly, a cannabis researcher at the University of Mississippi, explained that one reason for increased potency is users developing tolerance to the drug over time. This has led to a steady increase in THC content over the years.

“People need more potent products to achieve the desired high,” he noted.

Previously, a joint with 2% THC might have been enough, but as tolerance develops, individuals may need multiple joints or higher THC concentrations for the same effect.

Are some forms of marijuana safer?

Cannabis potency primarily refers to the THC content in the smokable parts like the flower or bud.

THC levels in flowers can reach up to 40%, while concentrates and oils may contain levels as high as 95%.

The challenge, according to UCLA’s Cooper, lies in the absence of a standardized dose for cannabis products, making it hard to predict individual reactions.

Establishing unit doses for inhaled products is also complicated. A joint can contain 100 to 200 milligrams of THC, but factors like inhalation depth and frequency of puffs affect actual exposure.

On the other hand, edibles typically contain 5 to 10 milligrams per serving. Efforts are underway to standardize dosing for edibles and regulate THC intake. For example, New York State limits edibles to 10 mg per serving.

How high can THC go?

Borkow of the National Institute on Drug Abuse believes that excessively high THC levels may induce extreme reactions like agitation and paranoia, predicting that marijuana flower THC levels won’t exceed 50%.

Cooper added that there is a threshold for THC production, but manufacturers are finding innovative ways to increase potency.

“The industry is boosting THC levels in plant products by adding extra THC, like injecting it into pre-rolled cannabis cigarettes,” she said. “We’re witnessing higher THC exposure levels than ever before.


Source: www.nbcnews.com

Bitcoin reaches an all-time high above $70,000

Bitcoin has reached a new all-time high price exceeding $70,000 following the announcement from the UK financial regulator permitting trading in crypto-backed securities.

On Monday morning, the cryptocurrency was trading at $71,588, surpassing its previous peak of nearly $69,000 achieved last week in November 2021.

This recent price surge comes after the UK financial regulator stated that it has no objections to investment exchanges listing crypto-backed public market segments, such as cETNs – a financial product that can be traded similarly to stocks.


However, the Financial Conduct Authority clarified that the sale of cETNs to retail investors or the general public is not permitted.

In a statement, the FCA cautioned that crypto assets are highly risky and essentially unregulated, warning investors to be prepared for potential loss of all funds.

Bitcoin has gained support this year following the approval of exchange-traded funds (ETFs) by U.S. financial regulators. ETFs are a collection of assets that mirror cryptocurrency prices and are tradable like stocks on exchanges.

Despite approval, Securities and Exchange Commission Chairman Gary Gensler expressed doubts about Bitcoin, viewing it as a speculative and volatile asset often used for illicit activities like ransomware and terrorist financing.

The upcoming “halving” of Bitcoin, which reduces the creation of new Bitcoins, is anticipated to bolster the currency by diminishing supply and consequently driving up prices.

Neil Wilson, a principal analyst at brokerage firm Finalt, viewed the FCA’s decision as a positive development for the crypto market. He remarked on the potential risks of parabolic market movements leading to significant declines, but expressed uncertainties regarding Bitcoin’s future.

Wilson also raised concerns about the availability of surplus funds for Bitcoin investments.

Source: www.theguardian.com

Green Bitcoin presale reaches $1 million while Bitcoin hits near all-time high – Blockchain News, Opinion, TV, Jobs

London, UK, February 29, 2024, Chainwire

Environmentally friendly virtual currency project green bitcoin More than $1 million was raised during the limited-time presale phase.

With an innovative gamified staking model and energy-efficient foundation, Green Bitcoin offers token holders a way to stake their tokens and generate revenue.

Gamified staking model offers a unique way to earn money

Green Bitcoin’s gamified staking model has a unique twist that allows token holders to attempt to predict Bitcoin’s daily price movements, and if successful, they receive a reward based on their accuracy and staking size. You can earn different rewards.

This system resets daily, ensuring continuous engagement.

Unlike common staking protocols with fixed yields, Green Bitcoin’s model offers dynamic yields.

As outlined in green bitcoin white paper the project has allocated over 27% of its total token supply to staking rewards, ensuring a huge amount of incentives for accurate BTC price prediction.

This pool of funds will be distributed over two years.

Green Bitcoin raises over $1 million as crypto market rapidly grows

Based on the revival of the cryptocurrency market, green bitcoin presale has crossed the $1 million mark and is offering discounted tokens to potential investors.

Unlike typical pre-sale setups, the team at Green Bitcoin encourages long-term holding by allowing users to immediately stake their purchased tokens.

Coinsult, a reputable blockchain security company, audited Token smart contract.

According to the company, there is growing interest in the project on Green Bitcoin’s social channels. of the project telegram groups I have seen growth over the past week. green bitcoin twitter account The number of followers has increased to 3,400.

Green Bitcoin is also featured in YouTube videos named: crypto boy praised its “Predict-to-Earn” model.

About Green Bitcoin

Green Bitcoin is a new crypto project on the Ethereum chain that offers a greener and more sustainable alternative to Bitcoin, as well as innovative “earn predictions” including staking rewards and weekly challenges for holders provide the element.

The Green Bitcoin Project was launched in late 2023 with a pre-sale hard cap goal of $7 million and has raised over $1 million to date. Smart contracts are audited by Coinsult.

Users can access Green Bitcoin Presale here

Green Bitcoin is the source of this content. This press release is for informational purposes only. This information does not constitute investment advice or investment recommendations.

contact

green bitcoin
contact@greenbitcoin.xyz

Source: the-blockchain.com

Review: Skull and Bones – A Swashbuckling Adventure on the High Seas

TWhat's frustrating about this adventurous multiplayer game from Ubisoft? reportedly It was in development hell for about 10 years. largely good.some things about it teeth. It offers interesting customization and even thrills when playing against well-matched opponents, including ship battles that are more flexible than you might expect. And when you're sailing from the coast of Africa to the East Indies, or navigating river channels surrounded on all sides by tropical wilderness, you can't help but admire the beauty of this game. And some things about it could get better. For now the menu is confusing, slow and messy time. A few tweaks could further increase the pace before pirate exploration becomes more exciting. This is a live service game, so there is room for evolution.

But some things about Skull and Bones are never going to be good, at least not without tearing them down and starting over, and after years of costly delays, it seems unlikely that that will ever happen. Seems low. All characters in this game have dead eyes and only their lips move when they speak. The story is so boring that even after spending over 20 hours at sea, I can tell you the relative value of rough stones and where to sell cigarettes for the most money, but I can't remember the names of a single character or faction. not. And when you're on the ground, there's no sword fighting, no treasure hunting, no meaningful exploration. A lot of effort has gone into creating a small oasis of land, but there's nothing there except a few quest-givers and a campfire. He only has two more populous pirate-based settlements on the whole map, and while you can at least find a blacksmith and a tavern, it's hard to find other interesting places to anchor.

This means you will spend 90% of your time sailing as all the action takes place on the waves. And if you're not plundering merchant ships or trying to protect yourself from other pirates, all you need to sail is raising and lowering your sails and occasionally adjusting your trajectory. Although boring, I found it peaceful to actually carry things and enjoy the scenery. The best part of Skull and Bones is the Indian Ocean. Occasionally, I felt a sense of quiet awe, such as when I was maneuvering a narrow cutter down a narrow road, seeing rocks towering from all sides and waterfalls cascading around corners. As the sun set, a soundtrack could be heard coming from the crew's shack. At that moment, like Ubisoft's Assassin's Creed games sometimes do, Skull and Bones felt like a recreation of a lost time, breathing new life into the Golden Age of Piracy.

A few tweaks could really speed up the pace – Skull and Bones. Photo: Ubisoft/Keza McDonald

Unfortunately, Assassin's Creed is the elephant in the room here. Skull and Bones is a super fun pirate-flavored adventure inspired by 2013's Assassin's Creed Black Flag. Felt It's an adventure, with lots of islands to explore, things to discover, and interesting stories to discover along with the thrill of sailing and firing cannonballs at your enemies. 2018's Assassin's Creed Odyssey still features a stunning voyage through the deep blue waters of ancient Greece, but there's so much more to do. Skull and Bones levels up sailing ever so slightly, and ship building is much better – changing ships and weapons makes a big difference in how you play – but it has nothing else to offer. The game has no personality or plot at all. The game that inspired it.

Another game I can't help but mention here is Rare's Sea of ​​Thieves. This is another online pirate action game that launched in 2018 in Barren State, but has since evolved into something fun, chaotic, and unique, and a great time with friends. As you would expect from a pirate game. But Skull and Bones is much more serious, lonely, and a completely different game. It reminded me more of Sid Meier's Pirates than Sea of ​​Thieves in that most of the game involves actually transporting or interfering with cargo. A faction of colonialists. The deeper you go, the more Skull and Bones will be tasked with manufacturing, selling, and transporting goods in hidden markets, or sinking other players to steal their goods. This is more than just a pirate game, it's a trade and naval battle simulator. Although he is not overbearing, he is a good sailor and has a wide selection of three-cornered hats.

If publisher Ubisoft continues to support it, Skull and Bones will appeal to avid players of naval warfare enthusiasts who enjoy tinkering with ship construction, facing off against each other, and teaming up to take on deadly fleets and cargo. It will attract a lot of people. However, if you're looking for a game that feels like a pirate adventure, Black Flag is still a better choice.

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Source: www.theguardian.com

Alphabet’s high profits overshadowed by advertising recession, leading to decline in Google investor confidence

Alphabet shares experienced a more than 5% drop in after-hours trading on Tuesday due to the tech giant’s shortfall in key advertising sectors, despite narrowly surpassing overall revenue estimates for the fourth quarter of 2023.

Google’s parent company disclosed that advertising revenue fell short of forecasts at $65.52 billion compared to $65.8 billion, but the overall revenue exceeded expectations at $86.31 billion versus $85.36 billion. This marked a 13% increase from the previous year.

The chief financial officer of Alphabet described the company’s results as “very strong,” emphasizing the surpassing of overall revenue expectations. “We remain committed to permanently restructuring our cost base while making investments to support growth opportunities,” she stated.

The response to the report was subdued after Google’s parent company laid off 1,000 employees in January. CEO Sundar Pichai announced at the end of the month that the company will refocus on “investing in key priorities,” particularly in the artificial intelligence elements integrated into Google’s flagship products, in 2024, and hinted at further job cuts.

Investors expressed encouragement Analysts believe that the recent job cuts may reflect prudent cost-cutting efforts amidst rising interest rates. However, the impact of the layoffs is evident, with Porat stating that severance pay in the first quarter of 2024 is expected to be $700 million. Alphabet recorded $2.1 billion in severance-related expenses and $1.8 billion in severance-related expenses in 2023, freeing up office space.


Despite the overall advertising downturn, Alphabet announced that YouTube ad revenue reached $9.2 billion, exceeding analysts’ predicted $9.16 billion and a significant increase from the same period in 2022.

CEO Sundar Pichai, in a statement accompanying the earnings call, expressed Alphabet’s pleasure with “the growing contribution from YouTube.” He also highlighted the company’s digital subscription services, including YouTube and cloud storage service Google One, achieving $15 billion annually.

“The significant growth in our subscription revenue over the past few years demonstrates the ability of our team to deliver high value-added services and provides a strong foundation on which to build,” he stated. Ta.

Like many other companies in the technology industry, Alphabet is aiming to take advantage of the AI ​​boom, with the mention of the word “AI” occurring more than 70 times in Tuesday’s earnings call. Pichai outlined the company’s plans to integrate its new AI model Gemini across various products, including search, advertising, and cloud.

Alphabet’s emphasis on AI comes as the company seeks to diversify its revenue streams. Its core search advertising business has stalled, and it faces growing antitrust litigation threats. The US Department of Justice filed a lawsuit against Google, alleging a monopoly on digital advertising technology. A judge’s ruling in January confirmed that the company will be forced to stand trial for charges brought by multiple states regarding advertising market dominance. The company also faced an antitrust case last year related to its dealings with other technology companies, including payments to Apple of about $18 billion annually to keep Safari’s default search engine.

“Google could have its toughest year yet as antitrust threats loom and the death knell sounds for third-party cookies,” stated Evelyn Mitchell Wolf, a senior analyst at Insider Intelligence. “We need to prepare ourselves for the possibility that something may happen.”

Source: www.theguardian.com

Uncommon footage captures killer whale guiding its calf in hunting and launching a dolphin high into the air

A rare video was captured this week by a whale-watching trip off the coast of San Diego, showing an orca teaching its baby how to hunt by headbutting a dolphin and flipping it over multiple times in the air.

Wildlife filmmaker Domenic Biagini, who shot the footage, described the scene, saying: “The killer whale catches the dolphin, but when the dolphin slows down, he releases it after it is subdued and brings the baby killer whale with him to catch it himself.” “Seeing that level of communication and understanding was like watching a family.”

Biagini owns Gone Whale Watching, one of several companies that spotted a pod of six orcas off the coast of San Diego on Monday. He said the orca hunt took about 30 minutes, which was much longer than the average orca hunt because he was teaching orca pups.

According to marine biologist Alisa Shulman Janiger, killer whales are among the ocean’s apex predators and are known to incorporate their large size and speed into their hunting strategies. She added that it is common for orcas to slow down the prey and show the children how to hunt.

Shulman-Janiger explained that the killer whales in the video are so young that their eye patches are yellow instead of white, a color that eventually fades as they get older.

Where do whales come from?

Shulman Janiger said the whale in Biagini’s footage is an eastern tropical Pacific orca, which typically lives in waters off Mexico and Central America. They are rarely seen in the relatively warm, calm waters of Southern California.

Speaking about the hunting behavior, Biagini said, “We try to explain to our guests that while what whales do to dolphins can sometimes be very gruesome, this is normal and healthy.”

Biagini also mentioned that after Monday’s hunt, the killer whales approached the boat to see what was going on and began to poke their heads out of the water, which is a behavior known as spy hopping.

‘Remember us at your Thanksgiving feast’: Killer whales celebrate the hunt

Biagini said the killer whales often celebrate after a successful hunt and zigzag back and forth through the water. He compared it to the feeling of happiness and smiling after a Thanksgiving meal.

Additionally, Biagini expressed concern about the increasing number of boats getting close to orcas to film social media videos, urging people to film animals in the most ethical way.

Danger of flocking to whale watching

Biagini also raised concerns about the number of boats surrounding the pod of killer whales, stating that too many boats with inexperienced operators could interfere with their hunting behavior or lead to collisions.

In a video he shot, a man driving a boat by himself abandons the wheel to lean out onto the deck to record the video.

Overall, Biagini emphasized the importance of being stewards of animals and approaching them in an ethical way.

Source: www.nbcnews.com

Nighttime exposure to high levels of light linked with higher risk of anxiety and depression

A large-scale study involving 87,000 participants found that while excessive night-time light exposure increases the risk of mental illness, increasing daytime light can reduce these risks. This groundbreaking study highlights the importance of balancing light exposure for mental health and suggests simple lifestyle adjustments for better health.

Exposure to artificial light at night increases the risk of developing mental illnesses such as anxiety, bipolar disorder, and post-traumatic stress disorder.PTSD), with a tendency toward self-harm.

The world’s largest study of the effects of light exposure on mental health, involving nearly 87,000 people, found that increased exposure to light at night increases the risk of mental health conditions such as anxiety, bipolar disorder and PTSD. Not only that, but it has also been shown that the possibility of self-injury increases. harm. Importantly, the study also found that enhancing exposure to natural light during the day may serve as a non-drug approach to reducing the risk of psychosis.

Day and night light exposure: a balancing act

People exposed to high amounts of light at night had a 30 percent increased risk of depression, while those exposed to high amounts of light during the day had a 20 percent decreased risk of depression. A similar pattern of results was found for self-harm, psychosis, bipolar disorder, generalized anxiety disorder, and PTSD. These findings demonstrate that the simple practice of avoiding light at night and seeking brighter light during the day may be an effective non-pharmacological means of alleviating serious mental health problems. is showing.

The study, led by Associate Professor Sean Kane from the Monash School of Psychological Sciences and the Turner Institute for Brain and Mental Health in Melbourne, Australia, was published today in the journal Nature Mental Health.

“Our findings have potentially significant societal impact,” said Associate Professor Kane.

“If people understand that light exposure patterns have a huge impact on their mental health, they can take some simple steps to optimize their health. Let in bright light during the day. , it is important to get darkness at night.”

The study’s 86,772 participants, all from UK Biobank, were tested for light exposure, sleep, physical activity and mental health. Associate Professor Kane said the effects of night-time light exposure were independent of demographics, physical activity, season and employment.

“And our findings were consistent when considering shift work, sleep, urban versus rural living, and cardiometabolic health,” he said.

Challenging human biology with modern lighting

Modern, industrialized humanity has literally turned our biological systems upside down. According to Associate Professor Cain, our brains have evolved to function best in bright light during the day and little to no light at night.

“Humans today are challenging this biology, spending about 90% of their days under indoor electric lights that are too dim during the day and too bright at night compared to the natural light-dark cycle. It confuses our bodies and makes us feel sick,” he said.

Reference: “Day and night light exposure is associated with mental illness: an objective light study of over 85,000 people” Angus C. Burns, Daniel P. Windred, Martin K. Rutter, Patrick Olivier, Celine Vetter, Richa Saxena, Jacqueline M Lane, Andrew JK Phillips, Sean W. Kane, October 9, 2023; natural mental health.
DOI: 10.1038/s44220-023-00135-8

Source: scitechdaily.com

The Impact of High Blood Pressure on Brain Immunity




NINDS Research on High Blood Pressure and Cognitive Decline

NINDS Research on High Blood Pressure and Cognitive Decline

by National Institute of Neurological Disorders and Stroke (NINDS) December 14, 2023

NIH-funded researchers have found that high blood pressure leads to an increase in interleukin-17 in the brain, which activates immune cells and causes cognitive decline. The discovery, made using a mouse model, points to the possibility of new treatments by targeting T cells in the brain’s protective membranes. Credit: SciTechDaily.com

An NIH-funded study in mice suggests a potential new target for treating hypertension. Research supported by National Institutes of Health The findings suggest that a response of immune system cells within the protective membrane that surrounds the brain may contribute to the cognitive decline that can occur in people with chronic hypertension. This discovery is natural neuroscience, may shed light on new ways to counter the effects of high blood pressure on cognition. This study was funded by the National Institute of Neurological Disorders and Stroke (NINDS), part of the NIH. “Understanding the role of immune signaling in cognitive decline is critical,” said Dr. Roderick Corriveau, NINDS program director. “These findings provide insight into how signaling from the immune system contributes to the symptoms of cognitive decline that ultimately lead to the diagnosis of dementia.”

Global impact of hypertension and its impact on cognition

High blood pressure affects more than 1 billion people worldwide and can cause cognitive decline not only when a stroke occurs, but even when a person with high blood pressure does not have a stroke. However, efforts to control cognitive decline in people who have not had a stroke with blood pressure-lowering treatments have shown mixed results. The results of this mouse study suggest that under conditions that mimic common hypertension, immune cells around and within the brain become abnormally activated, and that this activation leads to impaired brain function. Fluorescent staining reveals an extensive vascular network of the dura mater. These blood vessels contain her T cells, which are activated in mouse models of chronic hypertension, causing a condition that can lead to dementia-like symptoms. Credit: Iadecola Lab

Research Insights: Mouse models of hypertension

Researchers led by Costantino Iadecola, MD, director and director of the Feil Family Brain and Mind Institute in New York City, used a mouse model of hypertension to investigate interleukin-17 (IL-17). It was discovered that the levels of A chemical normally released in the body, cerebrospinal fluid, and brain to activate the immune system. Previously, Dr. Iadekola’s team showed that a high-salt diet increases IL-17 in the intestine, followed by cognitive impairment. These new findings further deepen the story by showing that IL-17 is acting within the brain itself. It is also worth noting that these experiments used a different mouse model called the DOCA salt model, which more closely mimics common hypertension in humans. “This is the most realistic model of hypertension that we have at this time,” Dr. Iadecola said. “DOCA mice simulate low-renin hypertension, a type of hypertension that is common in people, especially black Americans.”

Role of IL-17 and brain macrophages

Further research has shown that when IL-17 enters the brain, it activates immune cells known as macrophages, which are responsible for activating inflammation and fighting infections. A series of experiments showed that both mice with brain macrophage deletion of IL-17 receptors and mice with brain macrophage depletion showed no effect of hypertension on cognitive function, and therefore these macrophages were not associated with the observed cognitive function. It was confirmed that this is important for the reduction of Functioning despite other hypertension symptoms. Researchers were still looking for a source of IL-17 that acts on brain macrophages. Based on previous studies, the researchers’ initial hypothesis was that the gut releases IL-17, which travels to the brain through the bloodstream. Once there, a reaction is triggered that damages the ability of the brain’s blood vessels to respond appropriately to increased brain activity. However, blocking the ability of cerebral blood vessels to respond to IL-17 only partially reversed the cognitive impairment, suggesting that another source of IL-17 is acting on the brain. Uncovering IL-17 pathways and protective barriers One clue suggests that one layer of the brain’s protective layer, known as the dura mater, contains immune T cells that secrete IL-17 and may influence mouse behavior. taken from other recent studies. Using special mice whose cells glow fluorescent green when they make IL-17, the researchers found that high blood pressure increases IL-17 in the dura mater, which is then released into the tissues. Normally, a barrier exists within the brain’s protective covering called the meninges to prevent unwanted spillage into the brain. However, in mice with experimentally induced hypertension, this barrier appears to be disrupted, allowing IL-17 to enter the cerebrospinal fluid. Two additional experiments helped confirm this hypothesis. First, drugs were used to block the migration of her T cells from the lymph nodes to the meninges. Second, antibodies were used to block the activity of her T cells within the meninges. In both cases, the hypertensive mice recovered cognitive function, suggesting that targeting hyperactive T cells may be a new therapeutic approach worth exploring. “Taken together, our data suggest that hypertension causes two distinct effects,” Dr. Iadecola said. “One is that IL-17 has an effect on blood vessels, but this seems to be relatively minor. The more prominent central effect is that IL-17 releases IL-17, which has a direct effect on immune cells in the brain. It is caused by cells in the meninges. These immune cells, activated by signaling from the meninges, affect the brain in a way that ultimately causes cognitive impairment.”

Future Research Directions

Dr. Iadekola and his team are now trying to connect the dots between activation of immune cells in the meninges and cognitive decline. Previous works by the group The researchers suggested a link between a high-salt diet, which suppresses the production of the chemical nitric oxide in brain blood vessels, and the resulting accumulation of tau, a toxic protein that forms clumps within affected neurons. Alzheimer’s disease disease. The findings also indicate suppression of nitric oxide production in cerebral blood vessels, and whether this also leads to increased tau production is currently being investigated.

Reference: “Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension” Monica M. Santisteban, Samantha Schaeffer, Antoine Anfray, Giuseppe Faraco, David Brea, Gang Wang, Melissa J. Sobanko , Rose Sciortino, Gianfranco Rachumi, Ali Wiseman, Rybaik Park, Joseph Anraser, Costantino Iadecola, December 4, 2023, natural neuroscience.DOI: 10.1038/s41593-023-01497-z of NINDS’ Mind Your Risks® Campaign This paper highlights the relationship between high blood pressure and brain health (including risk of stroke and dementia), particularly in Black men aged 28 to 45, and provides recommendations to prevent and reduce the impact of high blood pressure on brain health. We offer strategies. This research was funded by NINDS (NS089323, NS095441, NS123507), the Leon Levy Fellowship in Neuroscience, and the Feil Family Foundation.


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