Scientists may have uncovered the key to solving a significant weight loss mystery

When it comes to weight loss, one universal truth stands out: losing body fat is challenging, and keeping it off can be even more difficult. A recent study may shed some light on why this is the case: adipose tissue, or body fat, retains a sort of “memory” even after cells have become obese.

“This discovery potentially helps explain the changes that occur in adipose tissue during weight fluctuations,” explained Dr. Ferdinand von Mayen, an assistant professor at ETH Zurich’s Faculty of Health Sciences and Technology, in an interview with BBC Science Focus.

Dr. von Mayen and his team observed transcriptional changes in human cells, which are responsible for regulating genetic material, in individuals’ adipose tissue before and after a 25 percent reduction in BMI. “We found that even after weight loss, the genetic regulation in adipose tissue did not fully return to normal, indicating that the body is programmed to regain lost weight,” he added.

While this news may be disheartening for those on a weight loss journey, Dr. von Mayen hopes that this study will help destigmatize weight fluctuations. “There is a molecular mechanism at play that influences weight regain, and it’s not simply a matter of willpower,” he emphasized.

He also stressed the importance of prevention in addressing the global obesity epidemic. “Early intervention is key, as it is much harder to lose weight once it has been gained. Implementing healthier lifestyle choices at a societal level is crucial in combating this issue,” Dr. von Mayen noted.

About our experts

Dr. von Mayen: I specialize in researching obesity and metabolic diseases at the Nutritional and Metabolic Epigenetics Laboratory at ETH Zurich.

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Source: www.sciencefocus.com

15 Exciting Science Riddles to Enjoy Solving with Your Family

1. The most common form of aluminum ore, wild goat, a rectangular array of numbers and radiation with wavelengths from 0.01 to 10 nanometers. What do they all have in common, and why did they make the news this year?

2. Four guests will be seated for Christmas dinner. One came from a valley in Germany. One was good with tools, one was said to be intelligent, and the other wanted a chair with a strong backrest. Three people leave the table one by one. Who will sit last?

3. In 2028, abolitionists and the God of Fire will be joined by crystallographers. where are they?

4. It’s time to gather around the table and bond. First, what can you make from these interesting food combinations?

Sweet nougat + chestnut udon

Chipolatas + Flaming Eggnog

Chocolate unicorn + tangy nachos

Angel gingerbread + Asian plum

5. How about going for a brisk walk to relieve the fatigue of your Christmas meal? Along the way, you’ll see a big dog that’s not on a leash, a big bear that’s not in a cave, and a ring that’s inside. I see a bull that is not there. where are you looking?

6. Hark! The pressure between the ship and its surroundings quickly equalizes, creating a wonderful, festive vibration. What just happened?

7. After receiving the clutch Tsugumi Merulaa trio of Gallus gallus domesticus and some Streptoperia turtlewhere do you think you can find it? Perdix?

8. Chinese giant SkyEye only has one, but labs tend to have a few and Christmas dinners have many. what is that? …

Source: www.newscientist.com

Solving the Enigma of Polycrystalline Materials

Researchers have used AI to uncover new insights into dislocations in polycrystalline materials, challenging existing scientific models and paving the way for improved material performance in electronics and solar cells. Credit: SciTechDaily.com

scientists of Nagoya University A Japanese research team is conducting research to understand tiny defects called dislocations in polycrystalline materials, materials widely used in information devices, solar cells, electronic devices, etc., that can reduce device efficiency. A new method was discovered using artificial intelligence.The research results were published in a magazine advanced materials.

Challenge of polycrystalline materials

Almost all devices we use in modern life contain polycrystalline components. From smartphones to computers to car metals and ceramics. Nevertheless, polycrystalline materials are difficult to utilize due to their complex structures. In addition to its composition, the performance of polycrystalline materials is affected by its complex microstructure, dislocations, and impurities.

A major problem when using polycrystals in industry is the formation of small crystal defects caused by stress and temperature changes. These are known as dislocations and can disrupt the regular arrangement of atoms in the lattice, affecting electrical conduction and overall performance. Understanding the formation of these dislocations is important to reduce the likelihood of failure in devices using polycrystalline materials.

Researchers used 3D models created by AI to understand complex polycrystalline materials used in everyday electronics.Credit: Kenta Yamakoshi

AI-powered discovery

A research team led by Professor Noritaka Usa of Nagoya University and consisting of Lecturer Tatsuya Yokoi, Associate Professor Hiroaki Kudo, and other collaborators is using new AI to investigate polycrystalline silicon, which is widely used in solar panels. We analyzed image data of a material called . AI created his 3D model in virtual space and helped the team identify areas where dislocation clusters were affecting the material’s performance.

After identifying regions of dislocation clusters, the researchers used electron microscopy and theoretical calculations to understand how these regions formed. They revealed the stress distribution within the crystal lattice and discovered a step-like structure at the boundaries between grains. These structures are thought to induce dislocations during crystal growth. “We discovered a special nanostructure in the crystal that is related to dislocations in the polycrystalline structure,” Professor Usami said.

Impact on crystal growth science

In addition to practical implications, this study may also have important implications for the science of crystal growth and deformation. The Hasen-Alexander-Smino (HAS) model is an influential theoretical framework used to understand the behavior of dislocations in materials. However, Professor Usami believes that he has discovered a dislocation that was missed by the Hasen-Alexander-Kakuno model.

New insights into the arrangement of atoms

Another surprise soon followed, as when the team calculated the arrangement of atoms within these structures, they discovered unexpectedly large tensile bond strains along the edges of the stepped structures that caused the creation of dislocations. .

Usami explains: “As experts who have been doing this research for years, we were surprised and excited to finally see evidence of the presence of dislocations in these structures. This suggests that we can control the formation of

Conclusions and implications for the future

“By extracting and analyzing, nanoscale “By combining experiment, theory, and AI, polycrystalline materials informatics has made it possible for the first time to elucidate phenomena in complex polycrystalline materials,” Usami continued. “This research is expected to shed light on the path towards establishing universal guidelines for high-performance materials and contribute to the creation of innovative polycrystalline materials. It extends beyond batteries to everything from ceramics to solar cells. semiconductor. Polycrystalline materials are widely used in society, and improving their performance has the potential to bring about social change. ”

Reference: “Polycrystalline informatics for polycrystalline silicon to elucidate the microscopic root cause of dislocation generation” Kenta Yamagoe, Yutaka Ohno, Kentaro Kutsukake, Takuto Kojima, Tatsuya Yokoi, Hideto Yoshida, Hiroyuki Tanaka, Liu Kin, Hiroaki Kudo, Noritaka Usa, December 2, 2023 advanced materials.
DOI: 10.1002/adma.202308599

Source: scitechdaily.com

Is Pulsar Light the Key to Solving the Dark Matter Mystery?

New research explores the possibility that dark matter is composed of theoretical particles called axions, and focuses on detecting them through additional light from pulsars. Although axions have not yet been confirmed in early observations, this research is critical to understanding dark matter.

A central question in the ongoing search for dark matter is: What is dark matter made of? One possible answer is that dark matter is made up of particles known as axions. A recent study by astrophysicists at the University of Amsterdam and Princeton University suggests that if dark matter is indeed made of axions, it could manifest itself in the form of subtle additional glow emanating from pulsating stars.

Dark matter may be the most sought-after building block in our universe. Remarkably, this mysterious form of matter, so far undetectable by physicists and astronomers, is thought to make up a huge portion of what exists on Earth. It is suspected that more than 85% of the matter in the universe is “dark”, and at the moment it is only recognized by the gravitational force it exerts on other celestial bodies. Naturally, scientists want to look directly detect its existence rather than just inferring it from gravitational effects. And of course they want to know what of course, solve two problems One thing is clear: dark matter cannot be the same kind of matter that makes up you and me. If so, dark matter would simply behave like ordinary matter. Dark matter will form star-like objects, will glow, and will no longer be “dark.” So scientists are looking for something new, a type of particle that no one has detected yet, and perhaps one that only interacts very weakly with the types of particles we know about.

One common hypothesis is that dark matter may be made of: Axion. This hypothetical type of particle was first introduced in the 1970s when he solved a problem that had nothing to do with dark matter. The separation of positive and negative charges inside a neutron, one of the building blocks of a normal atom, turns out to be unexpectedly small. Of course, scientists wanted to know why. It turns out that the presence of a previously undetected type of particle that interacts very weakly with components of neutrons can cause just such an effect. Frank Wilczek, who later won the Nobel Prize, came up with the name for this new particle. Axion – as well as similar to another particle name such as protons, neutrons, and electrons. photon, but it’s also inspired by the laundry detergent of the same name. Axion existed to solve problems. In fact, it might clean up the two even if it’s not detected. Several theories about elementary particles, including string theory, one of the leading candidate theories for unifying all the forces in nature, seem to predict the possibility of axion-like particles.

Fortunately, there appears to be a way out of this conundrum for axions. If the theory predicting axions is correct, not only would axions be expected to be produced in large quantities in the universe, but some axions could also be converted to light in the presence of strong electromagnetic fields. If there is light, we can see. Could this be the key to detecting axions and, by extension, dark matter? To answer this question, scientists first had to ask themselves where in the universe the strongest known electric and magnetic fields occur. The answer is known in the region around rotating neutron stars. pulsar. These pulsars (short for “pulsating stars”) are dense objects with a mass about the same as the Sun, but a radius about 100,000 times smaller, or only about 10 km. Because pulsars are so small, they rotate at enormous frequencies and emit bright, narrow beams of radio radiation along their axis of rotation. Just like a lighthouse pulsarThe beam can sweep across the Earth, making it easy to observe the pulsating star. But the pulsar’s massive rotation does more than that. it is, neutron star It turns into a very powerful electromagnet. That could mean Pulsar is a highly efficient axion factory. The average pulsar can produce 50 orders of magnitude axions per second. Because of the strong electromagnetic fields surrounding pulsars, some of these axions can be converted into observable light.

As always in science, carrying out such observations in practice is, of course, not so easy. The light emitted by axions (which can be detected in the form of radio waves) is only a fraction of the total light these bright cosmic lighthouses send back to us. Much less can we quantify the difference and turn it into a measurement of the amount of dark matter. This is exactly what a team of physicists and astronomers are currently doing. Through a collaboration between the Netherlands, Portugal, and the United States, the research team has uncovered details about how axions are created, how axions escape the neutron star’s gravity, and…

First observational tests were performed on the theory and simulation results…referencesystem, simulate a subtle glow

Next, first observational tests were performed on the theory and simulation results…referencesystem to show that it is very unlikely that axions are a component of…s

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Source: scitechdaily.com