CRISPR: Revolutionizing Genetic Code Editing – The Most Innovative Idea of the Century

New Scientist: Your source for the latest in science news and long-form articles from expert journalists covering advancements in science, technology, health, and environmental issues.

“The pain was like being struck by lightning and being hit by a freight train at the same time,” shared Victoria Gray. New Scientist reflects on her journey: “Everything has changed for me now.”

Gray once endured debilitating symptoms of sickle cell disease, but in 2019, she found hope through CRISPR gene editing, a pioneering technology enabling precise modifications of DNA. By 2023, this groundbreaking treatment was officially recognized as the first approved CRISPR therapy.

Currently, hundreds of clinical trials are exploring CRISPR-based therapies. Discover the ongoing trials that signify just the beginning of CRISPR’s potential. This revolutionary tool is poised to treat a wide range of diseases beyond just genetic disorders. For example, a single CRISPR dose may drastically lower cholesterol levels, significantly reducing heart attack and stroke risk.

While still in its infancy regarding safety, there’s optimism that CRISPR could eventually be routinely employed to modify children’s genomes, potentially reducing their risk of common diseases.

Additionally, CRISPR is set to revolutionize agriculture, facilitating the creation of crops and livestock that resist diseases, thrive in warmer climates, and are optimized for human consumption.

Given its transformative capabilities, CRISPR is arguably one of the most groundbreaking innovations of the 21st century. Its strength lies in correcting genetic “misspellings.” This involves precisely positioning the gene-editing tool within the genome, akin to placing a cursor in a lengthy document, before making modifications.

Microbes utilize this genetic editing mechanism in their defense against other microbes. Before 2012, researchers identified various natural gene-editing proteins, each limited to targeting a single location in the genome. Altering the target sequence required redesigning the protein’s DNA-binding section, a process that was time-consuming.

However, scientists discovered that bacteria have developed a diverse range of gene-editing proteins that bind to RNA—a close relative of DNA—allowing faster sequence matching. Producing RNA takes mere days instead of years.

In 2012, Jennifer Doudna and her team at the University of California, Berkeley, along with Emmanuelle Charpentier from the Max Planck Institute for Infection Biology, revealed the mechanics of one such gene-editing protein, CRISPR Cas9. By simply adding a “guide RNA” in a specific format, they could target any desired sequence.

Today, thousands of variants of CRISPR are in use for diverse applications, all relying on guide RNA targeting. This paradigm-shifting technology earned Doudna and Charpentier the Nobel Prize in 2020.

Topics:

Source: www.newscientist.com

Sam Altman Declares ‘Code Red’ for OpenAI Amidst ChatGPT’s Growing Competition

Sam Altman has issued a “code red” for OpenAI to enhance ChatGPT amid strong competition from other chatbots.

In a recent report from the technology news site Information, the CEO of the San Francisco-based startup informed staff in an internal memo: “We are at a critical time for ChatGPT.”

OpenAI is feeling the pressure from the success of Gemini 3, Google’s latest AI model, and is allocating additional resources to improve ChatGPT.

Last month, Altman informed employees that the launch of Gemini 3 had outperformed competitors. According to various benchmarks, this could result in “temporary economic headwinds” for companies. He added, “I expect the global atmosphere to remain stormy for some time.”

While OpenAI’s flagship product boasts 800 million weekly users, Google benefits from a profitable search business along with vast data and financial resources for its AI initiatives.




Sam Altman. Photo: Jose Luis Magaña/AP

Marc Benioff, CEO of the $220bn (£166bn) software company Salesforce, stated last month that he plans to switch to Gemini 3 and “never look back” after testing Google’s newest AI release.

“I’ve been using ChatGPT every day for three years. I just spent two hours on Gemini 3. I’m not going back. The leap is insane. Reasoning, speed, images, video… everything is clearer and faster. I feel like the world has changed again,” he remarked on X.

OpenAI is also scaling back its advertising efforts on ChatGPT as it prioritizes improvements to the chatbot, which recently celebrated its third anniversary.

Nick Turley, the head of ChatGPT, marked the anniversary with a post on X, committing to further innovations for the product.

“Our focus now is to further enhance ChatGPT’s capabilities, making it more intuitive and personal while continuing to grow and expand access worldwide. Thank you for an incredible three years. We have much work ahead!”

Despite not having the same cash flow support as rivals like Google, Meta, and Amazon, who fund competitor Anthropic, OpenAI has garnered substantial investments from firms like SoftBank Investment Group and Microsoft. At its latest valuation, OpenAI reached $500 billion, a significant increase from $157 billion last October.

OpenAI is currently operating at a loss but anticipates annual revenue to surpass $20 billion by year’s end, with Altman projecting that it will “grow to hundreds of billions.” The startup plans to allocate $1.4 trillion in data center costs over the next eight years to develop and maintain AI systems, aiming for rapid revenue growth.

Skip past newsletter promotions

“Considering the trends in AI usage and demand, we believe the risk of insufficient computing power at OpenAI is more significant and likely than the risk of excess computing power,” Altman stated last month.

Apple has also reacted to rising competitive pressure in the sector by appointing a new vice president of AI. John Gianandrea will be succeeded by Microsoft executive Amar Subramanya.

The company has been slow to integrate AI features into its products, while competitors like Samsung have been quicker to upgrade their devices with AI capabilities.

Subramanya comes to Apple from Microsoft, where he last served as vice president of AI. He previously spent 16 years at Google, including as head of engineering for the Gemini assistant.

Earlier this year, Apple announced that enhancements to its voice assistant Siri would be postponed until 2026.

Source: www.theguardian.com

Study: Bumblebees Can Be Trained to Understand Basic Morse Code

Bufftail Bumblebee (Western bumblebee): A recent study reveals that humans can determine foraging locations by analyzing variations in the length of visual cues.



The ability to process temporal information is essential for animal behaviors like foraging, mating, and avoiding predators. Although circadian rhythms are well-studied, there’s limited knowledge on how insects perceive durations in the second to subsecond range. Davidson and colleagues sought to assess the buff-tailed bumblebee’s (Western bumblebee) ability to distinguish between light flash durations in free-foraging tasks. Image credit: Miriam.

In Morse code, a brief flash or “dot” signifies the letter “E,” while a prolonged flash or “dash” indicates the letter “T.”

Previously, the capability to differentiate between “dots” and “dashes” was recognized solely in humans and certain vertebrates like macaques and pigeons.

Alex Davidson, a PhD student at Queen Mary University of London, and his team examined this ability in the Western bumblebee.

They designed a specialized maze to train the bumblebees to identify a sugar reward among two flashing circles, marked by long and short flashing intervals.

For instance, if a short flash, or “dot,” was linked with sugar, a long flash, or “dash,” would be associated with a bitter substance that bumblebees typically avoid.

Within each section of the maze, the locations of the “dot” and “dash” stimuli were altered, preventing the bumblebees from relying on spatial cues for their choices.

After mastering the task of approaching the flashing circles paired with sugar, the bumblebees were tested with flashing lights devoid of sugar, to determine if their selections were driven by visual cues instead of olfactory ones associated with sugar.

The results indicated that the bumblebees effectively learned to distinguish between light durations, as the majority headed straight to the “correct” blinking light duration that had been previously linked to sugar, irrespective of its spatial location.

“We aimed to investigate if bumblebees could distinguish among these various durations, and it was thrilling to observe them succeed,” Davidson noted.

“It’s astonishing that they excelled in this task, given that bumblebees encounter no blinking stimuli in their natural habitats.”

“The ability to track the duration of visual stimuli might imply enhanced temporal processing capabilities that have evolved for various functions, including spatial movement tracking or communication.”

“Alternatively, this impressive skill for encoding and processing time could be a fundamental feature of the nervous system, reflective of neuronal properties. Only further research can clarify this.”

The neural mechanisms that facilitate the tracking of these durations are still largely unclear. Current mechanisms known to align with solar cycles and seasonal changes are too slow to account for the distinction between dashes and dots of varying durations.

Numerous theories suggest the existence of either a singular or multiple biological clocks.

The revelation of insects’ capacity to differentiate between light flash durations will enable researchers to test various models using these “miniature brains” that measure less than a cubic millimeter.

“Numerous complex animal behaviors, including navigation and communication, rely on temporal processing capabilities,” comments researcher Elisabetta Versace from Queen Mary University of London.

“To explore the evolution of such abilities, adopting a comprehensive comparative approach across a range of species, including insects, is crucial.”

“Insect processing times highlight their utilization of minimal neural resources to accomplish complex tasks.”

“This insight holds implications for characteristics such as complex cognition in artificial neural networks, which should take cues from biological intelligence while striving for efficiency and scalability.”

This result was published in the Journal on November 12, 2025 in Biology Letters.

_____

Alexander Davidson et al. 2025. Bumblebee duration identification in the Western bumblebee. Biol. Let 21(11):20250440; doi: 10.1098/rsbl.2025.0440

Source: www.sci.news

Morse Code Messages Encased in Ice Bubbles

ICE can provide a method for long-term message storage in cold climates

Anton Petrus/Getty Images

Messages can be preserved in ice for millennia simply by altering the shape and positioning of the internal bubbles present.

Mengjie Song and his team at China’s Beijing University of Technology were exploring ice formation when they discovered that it influences the size and shape of bubbles encapsulated within. For instance, they found that freezing a layer of water between plastic sheets resulted in either oval or needle-shaped foam, depending on the freezing rate.

The researchers assigned specific bubble sizes, shapes, and positions to represent characters in Morse and binary code. By controlling the freezing rate of water, they created ice that conveyed messages through the embedded bubbles.

Transforming this ice image to grayscale revealed that white areas indicated the presence of bubbles, while black areas indicated the absence of them. This allowed computers to identify the size and location of bubbles for message decoding.

Currently, the amount of information that can be stored in conventional ice cubes is minimal with existing technology. However, Song suggests that by manipulating foam in materials like plastic, greater capacities could be achieved.

He mentions that beyond the novelty of reading messages embedded in ice cubes used in beverages, this research has diverse potential applications. “The strength of this study lies in its capability to sustain information over extended periods in frigid environments like the Arctic and Antarctic,” Song notes.

He envisions a future where bubbles could safely contain ozone for food preservation or act as carriers for slow-release medications. He is particularly intrigued by how bubbles can inhibit ice formation on airplane wings and how this knowledge could inform behavior in lunar environments.

However, Qiang Tang from the University of Sydney is more skeptical about the practical implications of this research, asserting that significant information can be long-term stored on hard drives and paper.

He comments, “This represents a novel method for conveying messages, but from a security and encryption standpoint, I see little value in it—unless, of course, a polar bear has something to communicate,” he adds.

Topic:

Source: www.newscientist.com

Review: “Source Code” by Bill Gay Tsu – Exploring the World of Computer Nerds and Their Struggles

tHe mystery surrounding William Henry Gates III is well-preserved. This book delves into the early years of Gates, from his birth in 1955 to the founding of Microsoft in 1975. The sequel will reveal the next chapter of his story.

The title of the book aptly captures its essence. In the era when only humans wrote computer programs, “source code” referred to the code that powered the programs. Understanding a programming language enabled one to decipher the workings of a computer program.

What can we learn from studying Gates’ journey? Essentially, it narrates the tale of a fortunate young man. He had supportive parents who provided him with the right environment to grow emotionally and intellectually. However, he faced internal battles due to his high IQ, rebellious nature, and anxiety.

Reflecting on his upbringing, Gates acknowledges the challenges he faced in social settings and how his parents supported him. He attended a progressive private school that nurtured his talents.

Notably, Gates and his friends had access to a computer in the 1960s, which was rare at the time. This early exposure to computing led them to develop software and write programs for companies in their region.

Gates’ journey took him to Harvard, where his programming skills stood out. He dabbled with a December PDP-10 but shifted focus when Allen discovered a new microcomputer based on Intel’s 8080 processor.

Together, Gates and Allen ventured into the world of software development, leading to the establishment of Microsoft. Their early success paved the way for future accomplishments.

The book hints at Gates’ institutional expansion and legal battles, setting the stage for what’s to come in the next volume.

Skip past newsletter promotions
Gates in 1983. Photo: DOUG WILSON/CORBIS/Getty Images

The book provides valuable insights into Gates’ formative years, shedding light on his complex personality. His early struggles and triumphs set the stage for his future endeavors.

One of the defining moments in Gates’ life was the tragic loss of his best friend and programming partner, Kent Evans. This loss deeply impacted Gates and influenced his career trajectory.

In a poignant moment, Gates reflects on his conversations with Evans’ father and imagines what could have been if Evans had lived. Their shared vision laid the foundation for what would become Microsoft.

Source: www.theguardian.com

Cracking the Code: Scientists on the Brink of Revealing the Secrets of Dark DNA

In the spring of 2003, the Human Genome Project completed the task of sequencing the human genome, marking a significant moment for science and life on Earth. The genetic revolution that followed raised questions about the meaning of the genome, particularly the fact that most of it seems to be non-coding. Less than 2% of the genome consists of genes that code for proteins, while the rest was once considered junk DNA.

However, recent research has shown that this “dark genome” plays a crucial role in regulating gene expression and has evolutionary significance. Long repeat sequences like transposons can impact genetic mutations and adaptation, leading to the development of features like opposable thumbs and the loss of tails in humans and apes. Understanding these once-neglected parts of the genome is now a focus of medical research for potential therapies for genetic diseases.

This article addresses the question of what makes up the other 98% of DNA, shedding light on the hidden functions of the dark genome. If you have further questions or want more information, you can reach out on our Facebook and Instagram pages.

Fun Facts: Check out this page for more amazing science and information.

For more details:or send us a message Facebook, Xor Instagram Page (be sure to include your name and location).

Ultimate Fun Facts For more amazing science, check out this page.

Source: www.sciencefocus.com

Researchers unravel the genetic code of the Etruscan shrew

Scientists sequenced and analyzed the genome. Etruscan shrew (Suncus etruscus), with an average weight of about 2 grams, it is one of the world’s smallest mammals. This reference-quality genome is an important resource for studies of mammalian development, metabolism, and body size control.

Etruscan shrew (Suncus etruscus). Image credit: Trebol-a / CC BY-SA 3.0 Certificate.

The Etruscan shrew, also known as the white-toothed pygmy shrew, is recognized as one of the smallest living mammals.

This species weighs 1.2 to 2.7 grams and has a body length of 3.6 to 5.3 cm (1.4 to 2.1 inches), with a very large surface area to volume ratio.

As a result, shrews have very high metabolic rates and must consume approximately 1.5 to 2 times their body weight in food each day.

These unique physiological characteristics make the Etruscan shrew a valuable species to the scientific community, contributing significantly to various research fields such as behavioral science and neuroscience.

“High-quality genome assemblies are essential references to enable accurate high-throughput data analysis,” said computational biologist Dr. Yuri Bukman of the Morgridge Institute.

“This will provide valuable insight into the mechanisms of body size control and metabolic rate and will facilitate comparative biological studies.”

In their research, Dr. Buchmann and his colleagues sequenced and assembled the genome of a male Etruscan shrew using protocols developed by the Vertebrate Genome Project.

“Our new Etruscan shrew genome is the first chromosome-level genome assembly for the order Shrews. lilypotyphra,” they said.

The authors manually inspected the primary assembly and identified 22 chromosomes, including the X and Y sex chromosomes.

They also identified 39,091 genes, 19,819 of which were protein-coding genes.

“We found that the shrew genome has relatively little duplication,” Dr. Buchmann said.

“This result does not necessarily correlate with the smallness of the shrew itself.”

“Although shrews belong to a different mammalian family, some similarly small rodents have a lot of overlapping body segments, and Mus musculus is like the champion in the sense that it has the most overlapping segments. So it’s not a question of size.”

of result It was published in the magazine scientific data.

_____

YV Buchman other. 2024. Chromosome-level genome assembly of the Etruscan shrew Suncus etruscus. scientific data 11, 176; doi: 10.1038/s41597-024-03011-x

Source: www.sci.news

The court orders Pegasus spyware creators to provide code to WhatsApp.

NSO Group, a maker of advanced cyberweapons, has been instructed by a US court to provide WhatsApp with the code for its Pegasus and other spyware products as part of an ongoing legal battle.

The ruling, issued by Judge Phyllis Hamilton, deals a significant blow to WhatsApp, owned by Mehta, who has been in a legal dispute with NSO since 2019 over allegations that the Israeli company’s spyware targeted 1,400 WhatsApp users over a two-year period, marking a major legal victory that lasted weeks.

NSO’s Pegasus code and other surveillance product codes sold by the company are considered highly classified national secrets. NSO is overseen by the Israeli Ministry of Defense, which must authorize all sales of licenses to foreign governments.

Despite NSO’s request to be exempt from the case’s discovery obligations due to US and Israeli restrictions, Judge Hamilton sided with WhatsApp. She ordered NSO to produce the spyware code and provide information on relevant spyware features used during a specified period.

However, on another issue, Hamilton ruled in favor of NSO, exempting the company from disclosing client names or server architecture details at this time.

A spokesperson for WhatsApp celebrated the court’s decision, stating that it marks a significant step in protecting users from illegal attacks by spyware companies. NSO declined to comment, and the legal battle continues.

NSO’s Pegasus software, once deployed against a target, grants unauthorized access to calls, emails, photos, location, and encrypted messages on mobile phones. The Biden administration blacklisted NSO in 2021, citing actions contrary to US foreign policy and national security interests.

NSO sells spyware to governments worldwide, claiming that the deploying agency is responsible for its use. Investigations have revealed countries like Poland, Saudi Arabia, Rwanda, India, Hungary, and the UAE using NSO technology against dissidents, journalists, activists, and civil society members.

Skip past newsletter promotions

NSO argues that Pegasus aids law enforcement and intelligence agencies in combating crime, protecting national security, and apprehending terrorists, child abusers, and violent criminals.

Concerned about the proliferation and misuse of products like Pegasus, the Biden administration announced a new policy imposing global visa restrictions on individuals involved in exploiting commercial spyware, extending to EU member states and Israel.

Source: www.theguardian.com

Researchers map the genetic code of sea cucumbers residing in hydrothermal vents

Chinese researchers have mapped the entire genome. chiridotaheheva a type of sea cucumber collected at a depth of 2,428 m during a submarine trip to a hydrothermal vent.



Chirodotaheheba In the Gulf of Mexico. Image credit: Aquapix and Expedition to the Deep Slope 2007.

The sea cucumber is echinoderm and as such are related to sea urchins and starfish, a group of animals with a very unusual body design.

They are found on the ocean floor around the world, where they devour detritus and use their tentacles to explore sediments.

Although other high-quality sea cucumber genomes are available, this study provides the first genome of a sea cucumber specimen. chiridotaheheva — collected at a hydrothermal vent.

beginning explained In 2004, chiridotaheheva It is known from the deep waters of the Western Atlantic Ocean, but has an international distribution.

It is one of the few echinoderms. occupy All three types of chemosynthetic ecosystems are included: hydrothermal vents, cold seeps, and organic fallouts. This suggests that this species is well adapted to the reducing environment of the deep sea.

Unlike most species that live in cold or hydrothermal vents; chiridotaheheva It does not host chemosynthetic bacteria.

It obtains nutrients from a variety of sources and extracts organic components from sediment debris, suspended solids, and wood debris when available.

“The organisms found in hydrothermal vents are among the most unique life forms on Earth, having evolved special adaptations to survive and reproduce in these harsh conditions,” said the lead author. Dr. Eugene Pu by Sanya Institute of Deep Sea Science and Technology and colleagues.

“For example, many microorganisms employ special metabolic functions to cope with the abundance of sulfur and iron and to withstand the enormous heat near the vent.”

“In addition to microorganisms, there are also multicellular and higher-order organisms that have adapted to the conditions of hydrothermal vents, such as various types of nematodes, snails, crabs, and shrimp.”

In the study, the authors sequenced the genome of an individual. chiridotaheheva collected from the ocean floor of the Indian Ocean Kairei Bent Field (2,428 meters deep).

“The water around the Kailey vent is particularly rich in dissolved iron, compounded by the harsh conditions of high hydrostatic pressure, darkness, and temperature fluctuations,” the researchers said.

“Initial comparative genomic analyzes showed that several gene families are expanded in this sea cucumber, meaning that this species has a higher repertoire of certain gene sets than closely related species. To do.”

“These expanded and unique genes are involved in DNA repair and iron metabolism, among other processes. It shows for the first time that it is reflected.”

“The genomic data will provide a valuable resource for further research on both sea cucumbers and unique spout animals.”

of result appear in the diary Giga Science.

_____

Y Pooh other. 2023. High-quality chromosome genome assembly of sea cucumber chiridotaheheva and its hydrothermal adaptation. Giga Science, in press. doi: 10.1093/gigascience/giad107

Source: www.sci.news

FTC warns of increasing QR code scams – Tips to safeguard against them

Since the COVID-19 pandemic, codes have grown in popularity and their use in the form of paperless menus and invoices has skyrocketed. But the convenience and efficiency of scannable codes comes with threats. Users can easily fall victim to fraud. According to a report by Check Point cybersecurity experts: 587% increase In phishing, or “kissing,” the Federal Trade Commission is also warning consumers who may be putting their personal information at risk. Cybercriminals send legitimate codes (also known as “quick response” codes, traditionally seen as a mix of white and black pixels that direct the scanner to a website) by sending the scanner to a fake site. It can be hidden with a unique code that steals personal and private information. Install malware. Fake codes can be found in public places, such as parking meters, or sent via texts or emails claiming there was suspicious activity on your account or there was a problem with your package delivery. There is also. The coronavirus pandemic has seen a surge in the use of codes, offering consumers a completely paperless way to view menus, pay bills, and fill out forms. adobe stock “We want you to scan a code and open a URL without thinking,” the FTC said. was warned about Wednesday’s blog post. To protect yourself, the FTC advised inspecting before opening them to make sure they haven’t been spoofed by misspellings or transposed characters. The agency also recommends not opening codes from unexpected communications (such as urgent messages indicating problems with your account), keeping your phone updated and enabling two-factor authentication. The FTC warned the public not to scan random codes and to be suspicious of unsolicited communications containing codes. adobe stock The Federal Bureau of Investigation’s September blog post also urged consumers to be skeptical and “suspicious” of codes that request login information after scanning, and further warned consumers not to scan codes that appear to have been “tampered with.” did.

Source: nypost.com