During the Mesolithic Age in East Asia, the discovery of stone tools reveals a complex range of human dynamics

The Mid-Lestic Age is considered a dynamic period in European and African history, but is generally considered a static period in East Asia. The discovery of a series of refined stone tools at Long Tang Sight in southwestern China, 50,000-60,000 years ago, challenges that recognition.



A product from the Quina system located at Longtan Site, China. Image credits: Luan et al. , doi: 10.1073/pnas.2418029122.

The Paleolithic period in the Central era occurred about 300,000-40,000 years ago and is considered an important time in human evolution.

This period is related to the origins and evolution of modern African people.

In Eurasia, it is associated with the development of several archaic human groups, such as the Neanderthals and Denisovan.

However, there is a widely believed belief that in most of the Paleostemic period, China’s development had slowed.

“Our discoveries challenge our current understanding of human history and technological development in East Asia,” said Professor Beau Lee of the University of Wollongong.

“This finding challenges a long-established general theory among archaeologists that China-China tools are relatively simple and unchanged.”

Professor Li and colleagues unearthed a rich collection of stone tools at the Longtan archaeological site in Yunnan, China.

This tool revealed a complete kina technology system that includes the cores used to generate large and thick flakes.

The Kina Industry is one of the most representative tool creation strategies developed in the Mid Paleolithic period around 300,000-40,000 years ago.

It is characterized by a steeply scaled retouch of thick flakes, which often produces robust scrapers with heavy edge modifications associated with neanderthals, representing strategies developed during marine isotope stage 4 as a response to open forest grassland environments and cool/dry climates.

The Kina Technical System was discovered in Western and Southern Europe during this period, but was not thought to have existed in East Asia.

The wear traces of Longtanquina scrape suggest that they are used in a variety of materials, including bones, horns, wood, meat, skin, and non-slow plants.

“Evidence has shown that the discoveries at Longtan significantly broadened the geographical distribution of human species, the tools used, and the adaptability to adapt to a variety of climates and environments,” Professor Li said.

“The discovery of Longtan also provides a perspective to understand how the human-leeze species evolved and evolved in East Asia prior to the massive arrival of early modern people 45,000 years ago.”

“Understanding rather old artifacts forces us to rethink models of human migration patterns and technology evolution in this part of the world.”

“This opens an exciting new avenue for research and, as we know, can rewrite East Asia’s prehistoric period.”

a paper The survey results were published this week Proceedings of the National Academy of Sciences.

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Qi-Jun Ruan et al. 2025. Kinarithic technology demonstrates the diverse late Pleistocene human dynamics of East Asia. pnas 122 (14): E2418029122; doi: 10.1073/pnas.2418029122

Source: www.sci.news

Hubble sheds light on atmospheric composition and dynamics of Uranus

The 20-year Hubble study of Uranus provides valuable data to help you understand the atmospheric dynamics of this distant ice giant. This serves as a proxy for studying the deformation of similar sizes and compositions.



The image sequence shows changes in Uranus over the past four years when Hubble’s STIS instrument observed Uranus over 20 years. Over that period, astronomers saw Uranus season as the Antarctic region (left) entered winter shadows, and the Arctic region (right) brightened, and began to become more direct view as summer approached the north. The top row of visible light shows how Uranus’ colours look to the human eye, as can be seen by even amateur telescopes. In the second line, false-colored images of the planet are assembled from visible and near-infrared light observations. The color and brightness correspond to the amount of methane and aerosol. Both of these quantities were indistinguishable before STI first targeted Uranus in 2002. Generally, the green area has less methane than the blue area, and the red area does not show methane. The red area is in the limbs, where the stratosphere of Uranus is almost completely free of methane. The two bottom rows show the latitudinal structures of aerosols and methane, inferred from those visible from 1,000 different wavelengths (colors) to near-infrared. In the third row, bright areas show cloudy conditions, while dark areas show clearer conditions. In the fourth row, the bright areas show depleted methane, and the dark areas show the total amount of methane. At mid- and low-latitude latitudes, aerosol and methane depletion has a unique latitude structure that has changed little over 20 years of observation. However, in polar regions, aerosol and methane depletion behave very differently. In the third row, aerosols near the Arctic show a dramatic increase, becoming very dark in the early days of the Northern Spring and very bright in recent years. It appears that aerosols also disappear in their left limbs when solar radiation disappears. This is evidence that solar radiation alters aerosol haze in Uranus’s atmosphere. On the other hand, methane depletion appears to remain very high in both polar regions throughout the observation period. Image credits: NASA/ESA/Erich Karkoschka, LPL.

Uranus is a giant ice planet about four times the diameter of Earth.

It has a hydrogen and helium feel and has a bit of methane that gives it a blue tint.

Uranus lies to its side and rotates, its magnetic field is biased – it tilts at the center 60 degrees from its axis.

When Voyager 2 passed Uranus in 1986, it provided a close-up snapshot of the planet facing sideways. What it saw resembled a bland blue-green billiard ball.

In comparison, Hubble recorded the story of 20 years of seasonal changes from 2002 to 2022.

During that period, it was used by a team of astronomers led by Dr. Erich Karkoschka of the University of Arizona and Dr. Larry Slomovsky and Dr. Pat Free of the University of Wisconsin. Hubble Space Telescope Imaging Spectrometer (stis) Draw an accurate picture of Uranus’ atmosphere structure.

Researchers observed Uranus four times in 20 years: 2002, 2012, 2015, and 2022.

They found that unlike gas giants Saturn and Jupiter, methane was not evenly distributed on Uranus.

Instead, it is heavily depleted near the pole. This depletion remained relatively constant for 20 years.

However, the structure of aerosols and hazes changes dramatically, and brightens significantly in the Arctic region as the planet approaches the northern summer solstice in 2030.

Uranus takes Earth age just over 84 years to complete the single orbit of the Sun.

Therefore, for over 20 years, the team has seen the spring almost north to make the Northern Pole shine directly in 2030, before shining the equator of Uranus.

“Hubble’s observations suggest a complex atmospheric circulation pattern for Uranus during this period,” the scientists said.

“The data most sensitive to methane distribution shows polar inundation and upwelling in other regions.”

Source: www.sci.news

Argentina’s lithium industry accelerates to fulfill electric vehicle demand, reshaping competitive dynamics

IIn the vast white desert of Salinas Grandes, 45-year-old Antonio Carpanchay raises an axe and chips away at the earth. He has worked the land since he was 12, splitting and collecting salt, replenishing it for the next season and teaching his children to do the same.

“Our whole indigenous community works here, even the elders,” he says, shielding his sunburned face from the sun. “We’ve always done it. It’s our livelihood.”

As his son watches warily, Karpanchai points north, to a pile of black stones and mud that stands out from the stark whiteness of the plains. “They started mining for lithium in 2010,” he says. “We made them stop because they were destroying the environment and affecting the water quality. But now they’re coming back, and I’m scared. We could lose everything we have.”

Antonio Carpanchay and his son mine and sell salt in Salinas Grandes, Argentina.

The Salinas Grandes are the largest salt flats in Argentina, stretching over 200 miles and containing a biodiverse ecosystem. Sitting in the Lithium Triangle The same goes for parts of Chile and Bolivia.

Lithium is a silvery metal known as platinum and is a vital element in batteries for mobile phones and electric cars. By 2040, global demand is predicted to increase more than 40-fold. But that exploitation has also raised moral debates, pitting the transition to green energy against the rights of local and indigenous peoples.

The sign reads “No to Lithium.”

Thirty-three indigenous communities in the Atacama and Cola regions, fearful of losing or polluting their water resources and being forced off their lands, have banded together for 14 years to try to halt the mining operations. “Please respect our territory” and “No to lithium” are scrawled on dozens of road signs, abandoned buildings, and murals.

But now, with more than 30 global mining conglomerates moving into the region at the instigation of “anarcho-capitalist” President Javier Milley, the battle lines are being redrawn. Offers of jobs and investment are increasingly dividing communities, with some already reneging on agreements and more expected to follow.

“Businesses are moving in,” Karpanchai said. “I worry about my grandchildren’s future.”


TThe biggest concern for indigenous peoples is water. Approximately 2 million liters of evaporation is required per tonne of lithium. This threatens to dry up the region’s wetlands and already dry rivers and lakes. Industrial-scale pumping also threatens to contaminate fresh groundwater, endangering livestock and small-scale agriculture. The impacts will likely reach farther than the immediate source of the water: as locals say, “water knows no borders.”

Clemente Flores, a 59-year-old community leader, says water is the most important part of Pachamama, which means “Mother Earth.” “Water nourishes the air, the soil, the pastures for the animals and the food we eat,” he argues.

“If we used all the water for mining, the salt flats would dry up. We need water to grow salt. Without salt, there are no jobs,” said Karpanchai, who relies on the freshwater resources to raise llamas and sheep. “Chemicals from mining could pollute the water and pastures. We could lose everything.”

Flavia Lamas, 30, a tour guide on the salt flats, remembers when lithium companies began exploring around 2010. “They said mining lithium would not affect Mother Earth, but then water became a problem. Water was running off the salt flats and after just one month our land started to degrade,” she says.

Flavia Lamas, who guides tourists through the Salinas Grandes salt flats, compares the mining companies to the Spanish colonial army of the 1500s.

According to Pia Marchegiani, director of environmental policy at the NGO: Environment and Natural Resources Foundation (Fern) Environmental assessments leave gaps in understanding the full impact of large-scale development. “This region is a watershed. Water comes from everywhere, but nobody is looking at the whole picture,” Marchegiani says. “You have Australians, Americans, Europeans, Chinese, Koreans, but nobody is adding up their water use.”

Wildlife within the ecosystem may also be affected. A 2022 study found that flamingosLithium mining in Chile is slowly killing off coral reefs that feed on microorganisms in seawater.

Communities also fear their land will disappear. Indigenous people consider the land sacred and ancestral, and have lived on it for centuries, but they worry they will be forcibly removed. “We can’t sacrifice our community land. Do you think that’s going to save the planet? Instead, we’re destroying Mother Earth herself,” Flores says.

A painting welcoming visitors to the village of El Moreno features an anti-lithium message.

youUntil recently, the 33 communities fought together as one, but over the past year, cracks have appeared as mining companies have offered economic incentives. “Companies are approaching,” Karpanchai said. “They approach us alone, they come in disguise. People are feeling the pressure.”

Lamas says mining companies are descending on the region like conquistadors in the 1500s. “The Spanish brought mirrors as gifts. Now the miners come by truck,” she says. “We’ve been offered gifts, trucks, and houses in the city, but we don’t want to live there.”

Marchegiani accuses the companies of deploying “divide and conquer” tactics. Alicia Chalabet, an indigenous lawyer from Salinas Grandes, says the community is under “constant pressure” to agree to the demands. “We’re flooded with lithium companies here. It’s increased a lot in the last five years,” said Chalabet, who is currently handling 20 cases. “The community is just an obstacle.”

The community of Lipan was the first to agree to let mining company Rishon Energy explore the waters beneath the saltwater in exchange for promises of jobs and essential services, but some residents say the decision was controversial, and some community members claim not all residents were allowed to vote.

A facility set up by Rishon Energy to explore lithium potential near the village of Lipan. The company claims to employ staff from the local area and invest in their training.

Rishon denies that its decision to mine in Lipan was controversial and says it complied with all regulations that require it to seek local community support in lithium exploration. The company has previously told reporters that it has invested in 15 secondary school and 15 university scholarships, provided computers to local schools, and hired 12 workers from Lipan.

Anastasia Castillo, 38, grew up in Lipan and now lives in a nearby commune. She says neither she nor her parents, who remain in the village, agreed. “I’m very sad. My children’s future is ruined. We have 100 cows and 80 llamas in the area, which is my main job. I’m afraid they’ll die,” Castillo said. “Now we’re separated.”

Anastasia Castillo believes that

Source: www.theguardian.com

New UCLA study challenges traditional views of bioengineering and stem cell dynamics

Confocal microscopy images show mesenchymal stem cells (green) captured within nanovials (pink). Nanovial technology was developed by Dino Di Carlo and colleagues at UCLA. Credit: Shreya Udani/UCLA
University of California Los Angeles Stem cell scientists have uncovered surprising genetic instructions for promoting protein secretion, with major implications for biotechnology and cell therapy.
Mesenchymal stem cells present in the bone marrow secrete therapeutic proteins that may help regenerate damaged tissue.
The UCLA study examining these cells challenges conventional understanding of what genetic instructions drive the release of these therapeutic proteins.
The discovery could help advance both regenerative medicine research and the laboratory production of biological therapeutics already in use.
Expanding the possibilities of antibody-based medicineToday, drugs based on antibodies (proteins that fight infection and disease) are prescribed for everything from cancer to disease. COVID-19 (new coronavirus infection) For high cholesterol. Antibody drugs are supplied by genetically engineered cells that act as small protein-producing factories in the lab.
Meanwhile, researchers are targeting cancer, internal organ damage, and many other diseases with a new strategy that involves transplanting similarly engineered cells directly into patients.
These biotechnological applications rely on the principle of causing cellular changes. DNA When a cell produces more genetic instructions to make a particular protein, it releases more of that protein.
Challenging established biological principlesBut a groundbreaking study from UCLA challenges this long-held belief, at least when it comes to certain types of stem cells.
The researchers looked at mesenchymal stem cells, which reside in the bone marrow and can self-renew and grow into bone, fat, and muscle cells. Mesenchymal cells secrete a protein growth factor called VEGF-A. Scientists believe this may play a role in blood vessel regeneration, repairing damage caused by heart attacks, kidney damage, arterial disease in the extremities, and other diseases.
Amazing discoveries in stem cell researchWhen the researchers compared the amount of VEGF-A released by each mesenchymal cell to the expression of the gene encoding VEGF-A in the same cells, the results were surprising. There was only a weak correlation between gene expression and actual growth factor secretion. Scientists have identified other genes that better correlate with growth factor secretion, including genes that code for proteins on the surface of some stem cells. The research team isolated stem cells with the protein on their surface, cultured a population that secreted large amounts of VEGF-A, and continued to secrete it even after several days.
Biotechnology and its impact on medicineThe findings were published Dec. 11 in the journal natural nanotechnologyco-author Dino Di Carlo said, suggesting that fundamental assumptions in biology and biotechnology may be worth reconsidering. UCLA Samueli School of Engineering.
“The central dogma is that there are instructions in DNA, and these instructions are transcribed. RNAThe RNA is then translated into protein,” said Di Carlo, who is also a member of UCLA. California Nanosystems Institute and Eli and Edythe Regional Center for Regenerative Medicine and Stem Cell Research. “Based on this, many scientists assumed that if you had more RNA, you would get more protein, and more protein would be released from the cell. I had doubts.”
It seems inconceivable that when a gene is expressed at a higher level, there is more secretion of the corresponding protein. We found a clear example where this does not occur, and many new questions arise.” Ta.
“The results could help make the production of antibody-based therapeutics more efficient and define new, more effective cell therapies. Knowing the right genetic switches to flip could enable the manipulation and selection of highly productive cells to create or deliver therapeutics.
Breakthrough in single cell analysisThe UCLA study was conducted using standard laboratory equipment enhanced with technology invented by Di Carlo and his colleagues. Nanovials, microscopic bowl-shaped hydrogel containers, each capturing a single cell and its secretions. By leveraging a new analytical method using nanovials, scientists were able to measure the amount of VEGF-A released by each of 10,000 mesenchymal stem cells compared to tens of thousands of genes expressed by that same cell. I was able to link it to the mapped atlas.
“The ability to link protein secretion to gene expression at the single-cell level holds great promise for the fields of life science research and therapeutic development,” said David, a member of the Broad Stem Cell Research Group and a professor of biology at the University of California, Los Angeles. said chemistry professor Kathryn Plath. Center and co-corresponding author of the study. “Without that, we would not have been able to reach the unexpected results found in this study. Now we have learned something new about the mechanisms that underpin the fundamental processes of life, and we have We have an incredible opportunity to leverage this to improve human health.”
A new path in therapeutic drug developmentAlthough activation of genetic instructions for VEGF-A showed little correlation with protein release, the researchers identified a cluster of 153 genes with strong associations with VEGF-A secretion. Many of them are known for their functions in blood vessel development and wound healing. For others, their functionality is currently unknown.
One of the top matches encodes the cell surface protein IL13RA2, but its purpose is poorly understood. Its outer location made it easy for scientists to use it as a marker and separate those cells from other cells. Cells with IL13RA2 showed 30% more VEGF-A secretion than cells lacking the marker.
In a similar experiment, the researchers kept isolated cells in culture for six days. At the end of that period, cells with the marker secreted 60% more VEGF-A compared to cells without the marker.
Potential impact on clinical applicationsMesenchymal stem cell-based therapies have shown promise in laboratory studies, but many of these new options are safe but not effective in clinical trials with human participants. It is shown that there is no. Her ability to use IL13RA2 to sort VEGF-A-rich cells could help change this trend.
“Identifying the subpopulations that produce more and the markers associated with that population means that they can be separated very easily,” Di Carlo said. “If we had very pure populations of cells that produced high levels of therapeutic proteins, we would have better treatments.”The nanovials are commercially available from Partillion Bioscience, a company co-founded by Di Carlo and founded in CNSI’s on-campus incubator. Expand.
Reference: “Correlating growth factor secretion in nanovials with single cell transcriptome using SEC-seq” Shreya Udani, Justin Langerman, Doyeon Koo, Sevana Baghdasarian, Brian Cheng, Simran Kang, Citradewi Soemardy, Joseph de Rutte, Kathrin Plath, Dino Di Carlo, December 11, 2023; natural nanotechnology.
DOI: 10.1038/s41565-023-01560-7The study’s lead author is Shreya Udani, who received her PhD from UCLA in 2023. Other co-authors, all at UCLA, are staff scientist Justin Langerman; Doyoung Koo, who received his Ph.D. in 2023. graduate students Sevana Bagdasarian and Chitradewi Somardi; undergraduate student Brian Chen; Simran Kang received her bachelor’s degree in 2023. and Joseph de Rutte, who completed his PhD in 2020 and is co-founder and CEO of Partillion.This research was supported by: National Institutes of Health It also won the Stem Cell Nanomedicine Program Award, jointly funded by CNSI and the Broad Center for Stem Cell Research.
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Source: scitechdaily.com

‘Avatar’ and ‘Jurassic Park’ animatronics company collaborates with Boston Dynamics

Since its inception as an MIT spinoff, Boston Dynamics systems have consistently provided entertainment value. The Hyundai-owned company has long embraced this by releasing dozens of highly viral videos over the decades.

However, with a few exceptions, entertainment was more of a side benefit than the ultimate goal. But that will change in the near future. just announced the deal A collaboration with Singapore-based entertainment brand Neon.


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Specifically (at least for our purposes) Neon is the parent company of Animax Designs. The Nashville-based company has created theme park and exhibit animatronics for some of Hollywood’s biggest franchises, including Avatar, Jurassic Park, Marvel, and Harry Potter.

No actual details have been revealed about the deal, other than the fact that it is “scheduled to culminate in late 2024 with an announcement that will captivate, inspire and surprise viewers.” Whether this means theme park robots or something else is completely unclear at this point.

A big advantage for Neon/Animax is that Boston Dynamics can produce robust, untethered autonomous systems at scale. The world of theme park robots has changed in recent years, with Disneyland’s Star Wars Galaxy’s Edge featuring robots that interact with park visitors.

“We are excited to collaborate with Neon and Animax on the development of a fully untethered entertainment robot,” Mark Thurman, Boston Dynamics’ chief strategy officer, said in a release. “These highly interactive creatures are poised to captivate consumers through novel and exciting initiatives. By partnering with Neon, a pioneer in immersive storytelling, we are proud to share our cutting-edge technology and the company’s ’s expertise in engaging storytelling.”

The agreement marks another step in Boston Dynamics’ commercialization roadmap, which began with Spot, a quadrupedal robot, and Stretch, a truck-unloading robot. But the company’s entertainment roots go back even further.mark lybert and team I also made a robot For the set of the 1993 Sean Connery/Wesley Snipes/Michael Crichton film Rising Sun.

Source: techcrunch.com