30 years later, the Sega Saturn remains a groundbreaking console ready to be rediscovered in retro gaming enthusiasts.

IIt’s one of the biggest injustices in video game history that the Sega Saturn is widely considered to be a failure. The console was released in Japan on November 22, 1994, almost two weeks earlier than the PlayStation, but has always been compared disparagingly to its rival. We hear that while Sony built high-end machine lasers intended to produce high-speed 3D graphics, Sega engineers had to add extra graphics chips to the Saturn at the last minute. I read that Sony’s Ken Kutaragi has provided creators with an even easier to use development system. We know that Sony used its power as a consumer electronics giant to take a financial hit and drive down the prices of Sega’s machines. That’s all true, but what’s always left unmentioned is the huge success of Japan’s Saturn launch and the extraordinary legacy left by Sega’s 32-bit machines.

What I remember is this. The Edge magazine reported from Akihabara, Tokyo, that its Japanese correspondent joined a line outside a major Laox computer game center to pick up one of the thousands of machines that fans had not yet reserved. I was trying to get it. Two and a half hours later, the author showed up with my purchase. Among them was a copy of Virtua Fighter, the best arcade fighting game of the year. It was a lucky purchase. Shelves around town were quickly emptying. Sega shipped an unprecedented 200,000 units that day.




The Saturn brought the feel of arcade titles like Daytona USA into your home. Photo: Justin Layton/Alamy

The following September, I joined Edge as a writer and stayed there for two years, coinciding with the creative peak of Saturn’s short life. What was clear to me at the time, and what still rings true today, is that Sega’s first-party output on this machine was one of the best of the decade. Arcade megahits “Sega Rally” and “Daytona USA” set the challenge for a new era of stylish 3D racers, while “Virtua Fighter 2,” “Fighting Vipers,” and “The Last Bronx” challenge the 1-on-1 brings complexity and depth to fighting games. Sega’s platform-exclusive titles were similarly vibrant and groundbreaking. Panzer Dragoon, Night Into Dreams, and Burning Ranger reinvented stalwart genres for a new generation with imaginative and rich visuals. But I also loved wacky experiments. There’s the toy-like platformer Clockwork Knight, the weird and frenetic puzzler Bakubaku Animal, and the self-consciously stupid Virtua Fighter Kids.

It’s often said that what Saturn lacked was support from third-party developers, but that wasn’t the case in Japan. Veteran shooter creator Treasure developed two of their best titles for this machine, Radiant Silvergun and Guardian Heroes. If you still want to play classic 2D shooter games, the Saturn is the way to go. Batsugan, Battle Garegga, and Darius Gaiden are all considered staples of the genre.




X-Men vs Street Fighter: Sega Saturn was the beginning of Capcom and Marvel’s relationship. Photo: ArcadeImages/Alamy

Atlus adapted the arcade hit Donpachi and created the underrated role-playing adventures Shin Megami Tensei: Devil Summoner and Princess Crown. For horror fans, there’s Warp’s survival thriller Enemy Zero, and Capcom created a Saturn port of Resident Evil that included exclusive mini-games and new enemies and costumes. Capcom also produced many of the best fighting games of the time, including X-Men: Children of the Atom (originally a home exclusive), X-Men vs. Street Fighter, and Darkstalkers 3. I put it into Saturn.

Sega also had decent developer support in Europe, with programmers who grew up on home computers having experience programming in the assembly language supported by the Saturn (the PlayStation had a much rarer development environment based on C). Core Design originally targeted Tomb Raider for machines (and also made the unfairly forgotten action-adventure Swagman for consoles). WipeOut brought Psygnosis. Gremlins loaded top-down brawler for both consoles. And Knutsford-based Traveler’s Tales, who would go on to create the Lego series, co-created the underrated racer Sonic R with Sonic Team. This was a great technology showcase for Saturn, with smooth frame rates and gorgeous transparency effects.

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The Saturn was innovative in other ways as well. Saturn Bomberman remains arguably the best title in Hudson’s explosive series, especially considering its support for chaotic 10-player matches with two multi-taps. The Saturn was the first major console to offer online gaming via a Net Link modem, and in 1997 it allowed players to participate in direct sessions of Sega Rally Championship and Virtual-On over the Internet. A party title that supported this technology was Shadows of the Tusk, a deck-building strategy role-playing game (years before the genre became mainstream) that came with its own physical card pack. Additionally, Sega’s 3D Control Pad, an analog controller designed specifically for Nights Into Dreams, outperformed the Nintendo 64’s pad by several weeks by market launch.

There was a period, perhaps for a year or two, when Saturn’s disappearance was inevitable. It held its own and rivaled everything that Sony and its lead development partner Namco could offer. Daytona vs. Ridge Racer, Virtua Fighter vs. Tekken, Virtua Cop vs. Time Crisis. And this rivalry has been an absolute boon for gamers, driving 3D game design and creating the technical expertise needed for the next generation of open-world 3D console titles. There’s a reason why refurbished and modified Saturns are still being sold on eBay and retro gaming sites 30 years after its release. They are often region-free and come with a switch to toggle between European 50Hz or NTSC 60Hz TV options. And that’s because the games I’ve mentioned here are still worth playing in their original form, their original home. Although the Saturn never really caught on as a mass market device, it was successful in many ways. When we think about the history of video games, we need to talk more about it.

Source: www.theguardian.com

In 2024, the Nobel Prize in Physics will be given to the duo behind a groundbreaking AI technology

SEI 224873524

John Hopfield and Jeffrey Hinton jointly awarded 2024 Nobel Prize in Physics

Christine Olson/TT/Shutterstock

The 2024 Nobel Prize in Physics will be awarded to John Hopfield and Jeffrey Hinton for their work on fundamental algorithms that enable artificial neural networks and machine learning, which are key to today’s large-scale language models such as ChatGPT. was awarded.

Upon hearing the award announcement, Hinton told the Nobel Committee, “I’m shocked. I never expected something like this to happen.” “I’m very surprised.” Hinton, who has been vocal about his concerns about the development of artificial intelligence, also reiterated that he regrets the work he did. “I would do the same thing in the same situation, but I fear that the overall impact of this will ultimately be controlled by systems more intelligent than us.” he said.

AI may not seem like an obvious candidate for the Nobel Prize in physics, but the discovery of learnable neural networks and their applications are two fields closely related to physics, the Nobel Committee for Physics says. Committee Chair Ellen Moons said during the announcement. . “These artificial neural networks are being used to advance research across a variety of physics topics, including particle physics, materials science, and astrophysics.”

Many early approaches to artificial intelligence involved giving computer programs logical rules to follow to solve problems, allowing them to learn about new information and It has become difficult for me to encounter situations that I have never seen before. In 1982, Hopfield at Princeton University created an architecture for computers called the Hopfield Network. A Hopfield network is a collection of nodes or artificial neurons whose connection strengths can be changed by a learning algorithm invented by Hopfield.

This algorithm is inspired by the study of physics to find the energy of a magnetic system by describing it as a collection of small magnets. The technique involves repeatedly changing the strength of the connections between the magnets to find the energy minimum of the system.

That same year, Hinton at the University of Toronto began developing Hopfield’s ideas to help create a closely related machine learning construct called a Boltzmann machine. “I remember going to a conference in Rochester where John Hopfield was speaking and learning about neural networks for the first time.After this, Terry [Sejnowski] And I worked hard to find ways to generalize neural networks,” he said.

Hinton and colleagues showed that unlike previous machine learning architectures, Boltzmann machines can learn and extract patterns from large data sets. This principle, combined with large amounts of data and computational power, has led to the success of many of today’s artificial intelligence systems, such as image recognition and language translation tools.

However, although Boltzmann machines have proven to be capable, they are inefficient and slow, so they are not used in today’s modern systems. Instead, it uses faster, modern machine learning architectures like Transformer models that power large language models like ChatGPT.

At the Nobel Prize press conference, Hinton was bullish about the impact of his and Hopfield’s discoveries. “It will be comparable to the industrial revolution, but instead of surpassing humans in physical strength, we will surpass humans in intellectual ability,” he said. “We’ve never experienced what it’s like to have something smarter than us. It’s going to be great in many ways…but we have We also have to worry about the negative consequences of this, especially the threat that these things can get out of control.”

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Source: www.newscientist.com

Webb makes a groundbreaking discovery of a region on a centaur with active outgassing

Centaur is a former trans-Neptunian object that has been moved within Neptune's orbit by the planet's subtle gravitational influence over the past several million years, and could eventually become a short-period comet.

29P/An artist's concept showing the gas release activity of Schwassmann-Wachmann 1 from the side. Image credit: NASA/ESA/CSA/L. Hustak, STScI.

Centaurs are transitional objects between primitive transsolar system objects and Jupiter-based comets.

Their composition and activity provide fundamental clues about the processes that influence the evolution of and interactions between these small celestial bodies.

“Centaurs are likely part of the remnants of the formation of our planetary system,” said Dr. Sarah Fudge, a researcher at NASA's Goddard Space Flight Center and American University.

“Because they are stored at very low temperatures, they preserve information about the volatiles of the solar system's early stages.”

“The web really opened the door for us to impressive resolution and sensitivity. When we saw the data for the first time, we were excited. We had never seen anything like this before. I've never had one before.”

use Webb's NIRSpec (near infrared spectrometer) deviceDr. Fudge and colleagues observed 29P/Schwasmann Wachmann 1 (29P for short) is a centaur. known This is because very active, quasi-periodic explosions occur.

29P changes in intensity every six to eight weeks, making it one of the most active objects in the outer solar system.

They discovered a new jet of carbon monoxide and a jet of carbon dioxide gas never before seen, giving new clues about the nature of the centaur's core.

No signs of water vapor were detected in 29P's “atmosphere,” but this may be related to the extremely cold temperatures present on this object.

Based on the data collected by Webb, the researchers created a 3D model of the jet to understand its direction and origin.

Through modeling efforts, they discovered that the jets were emitted from different regions of the centaur's core, even though the nucleus itself could not be resolved by the web.

The angle of the jet suggests that the core may be a collection of separate objects with different compositions. However, other scenarios cannot be ruled out yet.

fudge others. collected data for 29P/Schwassmann-Wachmann 1 using Webb's spectrophotographic capabilities. Image credit: NASA/ESA/CSA/L. Hustak, STScI/S. Faggi, NASA's Goddard Space Flight Center and American University.

Dr. Jeronimo Villanueva, a researcher at NASA Goddard Space Flight Center, said: “The fact that there are such dramatic differences in the abundance of carbon monoxide and carbon dioxide across the surface of 29P means that 29P is This suggests that it may be possible.”

“The two parts probably merged to form this centaur, which is a mixture of very different objects that went through separate formation paths.”

“This challenges our ideas about how primitive objects are created and stored in the Kuiper belt.”

The reasons for 29P's brightness outburst and the mechanisms behind its outgassing activity through carbon monoxide and carbon dioxide jets remain two major areas of interest that continue to require further investigation.

In the case of comets, scientists know that their jets are often driven by the release of water gas.

However, Centaur's location means that the nature of its outgassing activity is different from that of comets, as it is too cold for water ice to sublimate.

“We only had time to look at this object once, and it was like a snapshot in time,” said Dr. Adam McKay, a researcher at Appalachian State University.

“I would like to go back and look at 29P over a longer period of time. Is the jet always pointing in that direction? Perhaps there is another carbon monoxide jet that turns on at a different point in the rotation cycle? Is there one?”

“Looking at these jets over time will give us better insight into what is causing these explosions.”

of the team paper Published in a magazine nature.

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S.Fudge others. Inhomogeneous outgassing regions were identified in active centaur 29P/Schwassmann-Wachmann 1. Nat Astronpublished online on July 8, 2024. doi: 10.1038/s41550-024-02319-3

This article is a version of a press release provided by NASA.

Source: www.sci.news

VLBA uncovers groundbreaking information on the magnetars with the fastest spin rates

Swift J1818.0-1617 is located about 22,000 light-years away in the constellation Sagittarius.



Artist's impression of magnetar Swift J1818.0-1617. Image courtesy of NSF/AUI/NRAO/S. Dagnello.

Swift J1818.0-1617, discovered in 2020, rotates with a rotation period of 1.36 seconds and is thought to be the fastest rotating magnetar yet discovered.

The star is located on the opposite side of the Milky Way galaxy's bulge, 22,000 light-years away, making it relatively close to Earth.

In fact, it's so close that we can use parallax to pinpoint its 3D location within the galaxy.

The lifespan of magnetars is currently unknown, but astronomers estimate that Swift J1818.0-1617 is only a few hundred years old.

“A magnetar's bright X-ray emission requires a mechanism of extremely high-energy outflow. Only the rapid decay of its powerful magnetic field can explain the force behind these spectral features,” said Dr. Hao Ding, an astronomer at the National Astronomical Observatory of Japan, and his colleagues.

“But again, this is an extreme process: for normal stars on the main sequence, bright blue stars burn through their fuel much faster than yellow stars, and therefore have very short lifetimes.”

“In the case of magnetars, although the physics are different, their lifetimes are also thought to be shorter than those of pulsars.”

“Magnetars are too young to continue releasing energy at this rate for long periods of time,” the researchers added.

“Moreover, magnetars can also exhibit radiation in the lower end of the electromagnetic spectrum, i.e. at radio wavelengths.”

“In these cases, the most likely energy source is synchrotron radiation produced by the magnetar's rapid rotation.”

“In synchrotron radiation, the plasma surrounding the neutron star itself is so tightly attached to the surface of the star that it rotates at very close to the speed of light and produces radiation at radio wavelengths.”

Astronomers NSF's Very Long Baseline Array (VLBA) was conducted over a three-year period to collect data on the position and velocity of Swift J1818.0-1617.

“The VLBA provided excellent angular resolution to measure this extremely small disparity, and the spatial resolution is unmatched,” said Dr Ding.

Swift J1818.0-1617's parallax is the smallest of any neutron star, and its so-called transverse velocity is the smallest of any magnetar (a new lower limit).

“Velocity in astronomy can be most simply described as having two components: direction and velocity,” the researchers explained.

“Radial velocity tells us how fast we're moving along the line of sight. In this case, radial velocity means the speed along the radius of the galaxy.”

“For magnetars like Swift J1818.0-1617, which are located on the opposite side of the central bulge, there is too much other material in the way to accurately measure the radial velocity.”

“Transverse velocity, sometimes called proper velocity, describes motion perpendicular to the galactic plane and is more easily identifiable.”

Astronomers are trying to understand the common (and different) formation processes between regular neutron stars, pulsars and magnetars, and hope to use precise measurements of the transverse velocities to analyse the conditions under which stars evolve along one of these three paths.

“This study adds weight to the theory that magnetars are unlikely to form under the same conditions as young pulsars, and suggests that magnetars are born from a more unconventional formation process,” Dr Ding said.

“We need to know how fast magnetars were moving when they were first born. The mechanism by which magnetars form is still a mystery, and we want to find out.”

Source: www.sci.news

New: Groundbreaking drill core penetrates 1.2 kilometers into Earth’s mantle

A rock sample from Earth’s mantle viewed under a microscope

Johan Lissenberg

In the middle of the North Atlantic, geologists have drilled 1,268 metres below the seafloor – the deepest hole ever drilled into Earth’s mantle – and analysis of the resulting rock core may provide new clues about the evolution of the planet’s outermost layers and even the origin of life.

The Earth is generally made up of several different layers, including the solid outer crust, the upper and lower mantle, and the core. The upper mantle, located just below the crust, is made up primarily of magnesium-rich rocks called peridotites. This layer drives important planetary processes such as earthquakes, the hydrological cycle, and the formation of volcanoes and mountain ranges.

“Until now, we’ve only been able to see fragments of the mantle,” Johan Lissenberg “However, there are many places on the seafloor where the mantle is exposed,” said researchers from Cardiff University in the UK.

One such region is an underwater mountain called Atlantis Mountains, located near a volcanically active area of the Mid-Atlantic Ridge. Pieces of the mantle constantly come to the surface and melt, giving rise to the region’s many volcanoes. Meanwhile, as seawater seeps deeper into the mantle, it is heated by higher temperatures, producing compounds such as methane, which bubbles up from hydrothermal vents and serves as fuel for microorganisms.

“There’s a kind of chemical kitchen beneath the Atlantis massif,” Lisenberg says.

To learn more about this dynamic region, he and his colleagues initially planned to use the drilling ship JOIDES Resolution to drill 200 meters into the mantle, deeper than researchers had gone before.

“We then started drilling and it went surprisingly well,” a team member said. Andrew McCaig “We retrieved a very long continuous fragment of rock and decided to go for it and go as deep as we could,” said researchers from the University of Leeds in the UK.

Ultimately, the team succeeded in drilling to a depth of 1,268 metres into the mantle.

When the researchers analyzed the drill core samples, they found that they had a much lower content of a mineral called pyroxene compared to other mantle samples from around the world, suggesting that this particular part of the mantle underwent significant melting in the past, depleting it of pyroxene, Lisenberg said.

In the future, he hopes to recreate this melting process, which will allow him to understand how the mantle melts and how that molten rock travels to the surface to feed oceanic volcanoes.

Some scientists believe life on Earth began deep in the ocean near hydrothermal vents, so by studying the chemicals that show up along the cylindrical rock cores, microbiologists hope to determine the conditions that may have led to the emergence of life, and at what depths below the ocean floor.

“This is a very important borehole because it will provide a reference point for scientists across many scientific disciplines,” McCaig says.

“While a one-dimensional sample from Earth cannot provide complete information about the three-dimensional migration paths of melt and water, it is still a major achievement,” he said. John Wheeler At the University of Liverpool, UK.

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Source: www.newscientist.com

Amazon Workers in UK Warehouses Vote for Union Recognition: A Groundbreaking Moment

Located on a traffic island on the outskirts of Coventry, a small yet dynamic organizing team from the GMB union is challenging Amazon with homemade signs and orange bucket hats.

In a historic vote last week, over 3,000 Amazon workers were given the opportunity to participate in a vote that could potentially lead to the company recognizing a trade union in the U.K. for the first time. This is part of a series of battles worldwide over union recognition at the retail-to-cloud conglomerate founded by Jeff Bezos in 1994, now valued at over $2 trillion.

If successful, the GMB victory would grant workers the right to negotiate with Amazon on matters such as wages, hours, and holidays, something the famously anti-union company opposes. GMB also believes that recognition would give them an advantage in addressing health and safety concerns within the expansive Coventry warehouse, known as BHX4.

The ongoing campaign at BHX4 sheds light on the barriers unions face, despite promises from the new Labour government to bolster trade union influence.

Results of the vote, held after a month-long process, are expected on Monday. Workers have received support from local Labour Party MP Taiwo Owateme, who commended their efforts.


Kate Gorton, GMB member, union To raise awareness about voting, snacks, drinks and gifts were distributed to employees at the end of each shift. Photo: Fabio De Paola/Observer

At the approach to BHX4, a dedicated GMB team welcomes workers as they arrive for the night shift amidst the sounds of dhol drummers creating a festive atmosphere.

These workers are encouraged to vote “Yes!” and many show support by honking or signaling approval from their vehicles. The campaign aims to bring positive change to the work environment at BHX4.

Meanwhile, GMB activists at another entrance offer refreshments and free hats to workers, urging them to vote in favor of recognition.

Despite some workers bypassing the activists, many engage in conversation, accept hats and drinks, and express their support for GMB.

The GMB’s current push for full authorization is their second attempt after withdrawing the initial application last year, citing Amazon’s strategic hiring practices to influence the outcome.

As the vote results await, GMB and other trade unions remain hopeful for meaningful changes under Labour’s New Deal for Workers, advocating for stronger collective bargaining and workers’ rights.

Amidst Amazon’s resistance to unions globally, the Coventry activists persevere, optimistic that they can achieve historic recognition. The company maintains that employees have the choice to join a union and emphasizes its commitment to direct engagement with employees.

Source: www.theguardian.com

Juno Makes Groundbreaking Discovery of ‘Hot Ring’ on Io, Jupiter’s Volcanic Moon

These bright (hot) “heat rings” are a common phenomenon and indicate active lava lakes. Jupiter Infrared Auroral Mapper (JIRAM) instrument aboard NASA’s Juno spacecraft.

Visible, infrared and temperature maps of Loki Patera and Dazhbog Patera. Image courtesy of Mura others., doi: 10.1038/s43247-024-01486-5.

Io is the innermost of Jupiter’s four Galilean moons and the fourth largest moon in the solar system.

Apart from Earth, it is the only known place in the solar system with volcanoes that spew hot lava like Earth’s.

Io has over 400 active volcanoes, which are caused by tidal heating due to gravity from Jupiter and the other Jovian moons.

There are many theories about the types of volcanic eruptions on the Moon, but little data to support them.

NASA’s Juno spacecraft will pass by Io in May and October 2023, coming within about 35,000 km (21,700 miles) and 13,000 km (8,100 miles), respectively.

Among Juno’s observational instruments giving a closer look at the fascinating moon was JIRAM.

JIRAM is designed to capture infrared light emitted from deep within Jupiter, studying the weather layer 50 to 70 km (30 to 45 miles) below Jupiter’s cloud tops.

However, during Juno’s long mission, the mission team also used the instrument to study moons such as Io, Europa, Ganymede, and Callisto.

JIRAM images of Io showed the presence of bright rings surrounding the base of many hotspots.

“The high spatial resolution of JIRAM’s infrared images, combined with Juno’s favorable position during the flyby, revealed that Io’s entire surface is covered by lava lakes in caldera-like formations,” said Dr Alessandro Mura, a researcher at the National Institute for Astrophysics in Rome and Juno co-investigator.

“In the area of ​​Io’s surface where we have the most complete data, we estimate that about 3% of it is covered by one of these lava lakes. Calderas are large depressions that form when volcanoes erupt and collapse.”

This image taken by NASA’s Galileo spacecraft shows volcanic eruptions on Io. Image credit: NASA/JPL/University of Arizona.

JIRAM’s flyby data will not only reveal Io’s rich lava reserves, but also provide a glimpse into what’s going on beneath the surface.

Infrared images of some of Io’s lava lakes show a thin circular layer of lava at the boundary between the central crust that covers most of the lake and the lake walls.

The lack of lava flows above or beyond the lake’s edge suggests melt circulation, demonstrating a balance between the melt erupted into the lava lake and that circulated back into the subsurface system.

“We now know what the most frequent volcanic activity on Io is: huge lava lakes with magma rising and falling,” Dr Mura said.

“The lava crust collapses against the lake wall, forming the typical lava rings seen in Hawaiian lava lakes.”

“The walls are thought to be hundreds of metres high, which explains why magma is not typically observed spilling out of pateras – bowl-shaped formations formed by volcanic activity – and moving across the lunar surface.”

JIRAM data suggests that the surfaces of these Io hotspots consist largely of a rocky crust that periodically moves up and down as one continuous surface due to central upwelling of magma.

In this hypothesis, friction between the crust and the lake wall would prevent it from sliding, causing it to deform and eventually break away, exposing the lava just below the surface.

Another hypothesis, which remains valid, is that magma wells up in the middle of the lake, spreading out and forming a crust that sinks along the lake’s edge, exposing the lava.

“We’re just beginning to look at the results from JIRAM’s approach to Io in December 2023 and February 2024,” said Juno principal investigator Dr. Scott Bolton from the Southwest Research Institute.

“These observations reveal fascinating new information about Io’s volcanic activity.”

“When we combine these new results with Juno’s long-term campaign to monitor and map Io’s never-before-seen north and south pole volcanoes, JIRAM is poised to become one of the most valuable tools for learning about the workings of this tormented world.”

of Investigation result Published in a journal Nature Communications.

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A. Mura others2024. Io’s hot ring as seen by Juno/JIRAM. Community Global Environment 5, 340; doi: 10.1038/s43247-024-01486-5

Source: www.sci.news

The groundbreaking project aiming to decipher and potentially reverse menopausal age

From the moment you begin as an immature egg in your grandmother’s womb, your fertility journey is limited. However, scientists at Cambridge University may soon change that reality in their bright labs.

Dr. Staša Stankovic is one of these scientists. Her research at Addenbrookes Hospital in Cambridge has uncovered valuable data in the field. Now, Stankovic is focused on unraveling the mysteries surrounding fertility and menopause.

Women’s ovaries hold a finite supply of eggs that represent their fertility. Stankovic compares this concept to an hourglass, where the sand (eggs) can only flow in one direction until it runs out, signaling the onset of menopause.

“In science, we aim to control the hourglass’s middle part,” she explains. “Our goal is to limit the eggs’ loss over time, preserving the highest quality eggs for as long as possible.”

Working with a team for five years, Stankovic is developing a method to predict the natural fertile period and age of menopause with 65% accuracy, aiming for 80% accuracy in clinical practice.

Additionally, the team is exploring potential drug solutions to address infertility and potentially delay menopause. The onset of menopause is influenced by the ovarian reserve and the rate at which eggs deplete over a woman’s lifetime, typically occurring around age 50 with fewer than 1,000 eggs left.

For women experiencing early menopause or premature menopause, these drug treatments could be life-changing.

Your Menopausal Age

Researchers are studying genetic factors using a blood sample rather than physical examinations to understand how genes impact fertility and menopause.


The research team analyzed data from over 200,000 women in the UK Biobank, which provided insights into menopause, fertility, and overall health metrics. This data will help researchers make connections with other health outcomes like dementia and diabetes.

By identifying over 300 genetic variations linked to menopause, researchers foresee potential solutions for ovarian diseases and early menopause using drug interventions.

Stankovic cautions against relying solely on IVF and egg freezing as magical solutions, emphasizing the need for more effective treatments with higher success rates.

Effects of Delaying Menopause

The research team is hopeful about developing infertility drugs that not only address symptoms but also regulate ovarian function. While the drug’s availability is estimated within the next decade, rigorous testing and validation are still required.

The team’s focus is on identifying crucial genes, conducting testing in ovarian models, and formulating drugs that maintain egg quality and quantity as women age.

Ultimately, the goal is to delay menopause and extend reproductive lifespan. Preliminary studies on mice have shown promising results, but further research is needed before human trials can begin.

Aside from fertility benefits, delaying menopause could also impact women’s overall health, offering insights into various diseases associated with menopause.

About Our Experts

Dr. Staša Stanković is an ovarian genomicist with a PhD in reproductive genomics from the University of Cambridge. Her groundbreaking research has been published in top scientific journals, shedding light on the biological mechanisms behind ovarian aging and menopause.

Read more:

Source: www.sciencefocus.com

Certi AI celebrates the successful debut of their groundbreaking decentralized AI infrastructure token

Portland, Oregon, March 13, 2024, Chainwire

ceτi AI, a pioneering decentralized artificial intelligence infrastructure provider, is pleased to announce the successful launch of the CETI token. Founded by a visionary team led by Dennis Jarvis (ex-Bitcoin.com and Apple), ceτi AI builds a globally distributed, high-performance, intelligent, and scalable infrastructure network that supports innovative technologies. Our mission is to democratize access to AI. Decentralized AI network. Through these efforts, ceτi AI fosters innovation and developer engagement around the world.

Launched on Uniswap on March 11, 2024, the CETI token contributes to the development of AI infrastructure and introduces a unique way to benefit from the value created by the ceτi AI network. The launch received widespread attention, achieving an initial market capitalization of $33 million and a significant trading volume of $5.6 million in the first 24 hours of trading, demonstrating strong market confidence in ceτi AI's vision. Ta. Early adopters can expect to be the first to realize the benefits of holding CETI tokens.

The token launch not only showed impressive early market performance, but also saw over 1,000 early adopters join the project's Discord and Telegram groups, engage with tens of thousands of users on X.com, and trend #1 It marked an important milestone in the growth of the community, including winning the. It will be added to the DEX tool's hot pair list. ceτi AI's commitment to responsible tokenomics, stable and secure token markets, and revenue-generating AI infrastructure capabilities has received enthusiastic support from both the cryptocurrency and AI communities.

Dennis Jarvis, CEO of ceτi AI, said: “Reflecting on the successful launch of the CETI token, our sights are set on the decentralized AI horizon.” “Soon, advanced machine intelligence will impact every aspect of our lives. This power should not be blindly given to centralized so-called “trust and safety” teams. We must build a decentralized and democratized future for AI. ceτi AI is deploying the infrastructure to make it possible for anyone, anywhere. ceτi AI remains dedicated to ensuring that token holders and community members are integral to our journey, receive continued value, and have a say in the evolution of the ecosystem. I'll go. By fostering an environment of open innovation and collaboration, we are paving the way to a future where the benefits of AI are available to everyone, ensuring that technology serves the greater good and empowers individuals around the world. To do.

Join us on our journey to accelerate progress in decentralized AI. To learn more about ceτi AI and how to get involved, please visit: http://taoceti.ai Follow us on X (https://x.com/ceti_ai),telegram(https://t.me/ceti_ai),discord (https://discord.gg/SvauY42HdT), and DEX tools (https://t.ly/sj5eB). Contact our team. https://calendly.com/ceti_ai/ To arrange a meeting at the NVIDIA GTC Conference on March 18, 2024 in San Jose, California.

contact

CEO
Dennis Jarvis
Chey Eye
press@taoceti.ai

Source: the-blockchain.com

A groundbreaking treatment on the horizon for controlling and preventing cancer

It is estimated that one in two people will develop cancer during their lifetime. However, advancements in diagnosis and treatment have led to more people surviving cancer than ever before. The question now is, will this trend of increasing survival rates continue, and how close are we to finding a cure?

The trend of improving survival rates is likely to continue, but the discovery of a cure for cancer is complicated due to the fact that cancer is not a single disease, but rather a group of over 200 diseases, each with its own unique characteristics. Despite this complexity, all cancers originate from mutant cells that divide uncontrollably.

While cancer cells evade normal controls on cell division, targeted cancer therapy has emerged as a promising treatment approach. This therapy focuses on inhibiting genetic mutations that drive cancer growth and has shown to be more effective with fewer side effects than traditional treatments like chemotherapy and radiation therapy.

Targeted therapies like hormone therapy and drugs such as imatinib have revolutionized the treatment of certain types of cancer, improving survival rates significantly. The development of new drugs and the repurposing of existing ones have been accelerated by genetic technologies that utilize big data to understand genetic changes driving cancer.

The power of big data

Advances in cancer treatment have been further propelled by genetic technologies and clinical trials that utilize big data to develop new drugs and repurpose existing ones. The Cancer Genome Atlas Project, for example, provides valuable genetic information for various types of cancer, allowing for targeted treatments based on individual genetic profiles.

Credit: Getty Images

While drug treatments have seen significant advancements, immunotherapy has also emerged as a promising approach in cancer treatment. Immunotherapy aims to boost the patient’s immune system to detect and destroy cancer cells more effectively. This field is rapidly evolving, with treatments like immune checkpoint inhibitors and adoptive cell therapy showing promising results.

Vax is on track

Developments in cancer immunization, including mRNA-based vaccines, are changing the landscape of cancer treatment by utilizing the body’s immune system to target cancer cells. Early diagnosis remains crucial in cancer treatment, with advancements in AI technology offering improved diagnostic capabilities.

Prevention is also a key focus in the fight against cancer, with vaccines against infectious causes of cancer such as HPV and HBV showing promising results. Additionally, cancer prevention strategies using drugs or vaccines to eliminate cancer cells before they form detectable tumors are gaining traction.

While a single “cure” for cancer may be unlikely, ongoing advancements in diagnosis, treatment, and prevention offer new hope to cancer patients worldwide. The future of cancer treatment holds the promise of personalized medicine, targeted therapies, and innovative approaches to combat this complex disease.

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Source: www.sciencefocus.com

Top 10 Groundbreaking Medical Advancements: Pure Moments of Eureka captured in Photos

The history of science is filled with moments of discovery, those “Eureka” moments when a theory is proven or a breakthrough is achieved. The latest image competition at Great Ormond Street Hospital, titled ‘A Moment of Discovery’, celebrates these breakthroughs.

Staff from Great Ormond Street Children’s Hospital NHS Foundation Trust (GOSH) and its partners have submitted images capturing significant milestones in research. The public voted on the three most popular images shortlisted by a panel of experts via social media.

The shortlisted images range from colorful micrographs to cartoon illustrations, offering a glimpse into the research conducted at GOSH. It is hoped that this research will lead to new treatments for rare and complex conditions, transforming the lives of children and young people with serious illnesses.

The winning image, taken by PhD student Giada Benedetti at the Zayed Pediatric Rare Disease Research Center (ZCR), shows exploding intestinal organoids revealing their inner workings.

Organoids are small three-dimensional tissue cultures derived from stem cells that can mimic different organs like the heart and liver in the human body.

In honor of Rare Disease Day on February 29, all winning and shortlisted images will be displayed at an event at the Zayed Pediatric Rare Disease Research Center.

Selected as a finalist – my lungs are on fire

These lung “mini-organs,” or organoids, were grown from stem cells to replicate the complexity of lungs. The image showcases cell nuclei in blue, cell membranes in red, and moving hair-like structures called cilia in yellow/orange. Photo courtesy of Giuseppe Cala at GOSH.

Shortlist – Active Glial Cells

The image showcases nerve helper cells, known as glial cells, with long fibrous structures that transport nutrients and oxygen to surrounding nerve cells. Photo courtesy of Lucien Bonfante at GOSH.

Finalist – Light of Life

The image shows the spinal cord of a zebrafish embryo with different neurons generated through asymmetric division. Photo courtesy of Atachapon Theppichaiyanond at GOSH.

Source: www.sciencefocus.com

Groundbreaking Discovery in Quantum Gravity May Lead to a Unified “Theory of Everything”

Curious about what goes on inside a black hole? Wondering about the origins of the Big Bang and how the forces of the universe came together? These are some of the biggest questions humanity has about the universe, and new discoveries are bringing us closer to the answers than ever before.

Scientists have made a breakthrough in measuring gravity in the quantum world, with British, Dutch, and Italian teams utilizing new technology to detect weak gravity on small particles. By suspending particles weighing just 0.43 mg at ultra-low temperatures, they were able to isolate the vibrations of the particles using magnets and superconducting devices.

This groundbreaking technique allowed scientists to measure weak attractive forces of only 30 attonewtons (aN), a force smaller than that of a bacterium on a table’s surface. Previously, understanding how gravity worked at the microscopic level had eluded scientists, but this discovery has shed light on the interaction of forces with particles at a small scale.

Lead author of the study, Tim Hooks from the University of Southampton, noted that scientists have been struggling for a century to understand how gravity and quantum mechanics interact. This new discovery brings us closer to unraveling the mysteries of the universe and potentially paves the way for further advancements in measuring quantum gravity.

By continuing to refine the method used in this study, researchers hope to delve deeper into the forces that govern the universe, ultimately leading to a better understanding of the very structure of our cosmos.

“We are on the brink of new discoveries about gravity and the quantum world,” said Professor Hendrik Ulbricht, one of the study authors.

For more information, visit Professor Hendrik Ulbricht’s profile.

Source: www.sciencefocus.com

Indian teenager creates ground-breaking device with potential to revolutionize dementia care on a global scale

IDuring the blissful summer that Hemesh Chadarabada spent with his grandmother in 2018, they watched endless movies and ate her grandmother's chicken biryani. Late one evening, while Chadaravada, then 12, was sitting alone in front of the television, Jayasree got up in her nightgown and went to her home in Guntur, southern India, to make her a cup of tea. Ta.

After returning to her bedroom, Chadarabada went into the kitchen and noticed that her grandmother, then 63, had left the gas on.

“She was recently diagnosed with Alzheimer's disease, and I was still in shock. What would have happened if I hadn't been there?” Chadaravada says.

Chadarabada shows her grandmother the prototype of the device. Photo: Handout

Chadaravada knows that Jayasree is not only a loving grandmother but also a dynamic and successful woman with a high-profile career as a civil servant who interacted with Telangana's top politicians and policy makers. Ta.

But Alzheimer's disease changed her forever. “She would wake up at 3 or 4 in the morning and she would go outside thinking she was on the train,” he says.

During that happy summer, Chadarabada, a self-confessed geek from Hyderabad who loves robotics, decided he wanted to invent a device to help people like his grandmother.

Now 17 years old, Chadarabada is ready to start building a device to detect falls and wandering in Alzheimer's patients, something that is not possible with currently available devices.

Light and compact, Alpha Monitor can be worn as a badge or armband and sounds an alarm when the wearer begins to move, alerting caregivers if the patient falls or wanders.

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Most similar devices work over Wi-Fi or Bluetooth, so if a person moves outside of the frequency's restricted range, they lose connectivity and, with it, monitoring. However, Alpha Monitor Lolait uses.

Chadarabada taught himself by watching YouTube videos about robotics and electronics and developed 20 prototypes.

Understanding the needs of Alzheimer's disease (Alzheimer's disease in India) patients Estimated 8.8 million people), spent time at a day center run by the Alzheimer's Disease Related Disorders Association of India.

Webb’s groundbreaking perspective on the concealed rings of Uranus

The James Webb Space Telescope captures revealing images of Uranus

The James Webb Space Telescope has taken detailed images of Uranus, revealing its dynamic atmosphere, including rings, moons, and storms. This enhanced view, in contrast to previous images, shows a more active Uranus, with a pronounced seasonal polar cloud cap and some storms. These observations are essential for understanding the planet’s complex atmosphere and may also provide insight into the study of exoplanets.

Credit: NASA, ESA, CSA, STScI

New view reveals strange and dynamic ice world

When Voyager 2 passed Uranus In 1986, the planet appeared as a featureless, bright blue sphere. Now, Mr. Webb shows a more dynamic and interesting infrared view. Tree rings, the moon, storms, and the bright polar cap grace these new images. Because Uranus is tilted sideways, its polar caps appear more prominent as Uranus’s poles point towards the Sun and receive more sunlight. This period is called the winter solstice. Uranus will reach her next summer solstice in 2028, and astronomers will observe changes in the planet’s atmosphere. Studying this giant ice cube can help astronomers understand the formation and meteorology of similarly sized planets around other suns.

This image of Uranus taken from the NIRCam (Near Infrared Camera) on NASA’s James Webb Space Telescope shows the planet and its rings in new clarity. The planet’s seasonal polar cap shines bright and white, and Webb’s exquisite sensitivity resolves Uranus’ dim inner and outer rings, including the planet’s closest very faint and diffuse ring, the Zeta ring.

Credit: NASA, ESA, CSA, STScI

Webb Space Telescope rings with ringed planet Uranus on holiday

NASA’s James Webb Space Telescope recently set its sights on the unusual and mysterious Uranus, an ice giant spinning on its side. Webb used other atmospheric features to capture this dynamic world, including rings, the moon, storms, and seasonal polar caps. This image expands on his two-color version released earlier this year, adding a wavelength range for an even more detailed look.

Uranus’ rings and moon in new light

With exquisite sensitivity, Webb captured Uranus’ dim inner and outer rings, including the elusive Zeta ring, the planet’s closest very faint and diffuse ring. It also photographed many of the planet’s 27 known moons, and several smaller moons were also visible in the ring.

At visible wavelengths observed by Voyager 2 in the 1980s, Uranus appeared as a gentle blue sphere. At infrared wavelengths, Webb reveals a strange and dynamic icy world full of exciting atmospheric features.

This image of Uranus taken with the Webb Near-Infrared Camera (NIRCam) shows a compass arrow, scale bar, and color key for reference.

Credit: NASA, ESA, CSA, STScI

Atmospheric phenomena and seasonal changes

One of the most impressive of these is the planet’s seasonal arctic cloud cap. Compared to images on the web from earlier this year, these new images make it easier to see some of the details on the cap. These include a bright white inner cap and dark lanes at the bottom of the polar cap toward lower latitudes. Several bright storms are also visible near and below the southern boundary of the polar cap. The number of these storms, and how often and where they appear in Uranus’ atmosphere, is likely due to a combination of seasonal and meteorological influences.

Polar caps become more visible as the planet’s poles begin to move toward the sun and receive more sunlight as the planet approaches the summer solstice. Uranus will reach her next summer solstice in 2028, but astronomers are keen to observe possible changes to the structure of these landforms. Webb helps disentangle the seasonal and meteorological influences that affect Uranus’ storms. This is important for helping astronomers understand the planet’s complex atmosphere.

Uranus’s unique tilt and future research

Because Uranus rotates on its side at an angle of about 98 degrees, it experiences some of the most extreme seasons in the solar system. For almost a quarter of Uranus’s year, the sun shines above one pole, and the other half of the Earth plunges into a dark winter that lasts her 21 years. Webb’s unparalleled infrared resolution and sensitivity now allows astronomers to observe Uranus and its unique features with groundbreaking new clarity. These details, especially those of the close Zeta ring, will be invaluable in planning future missions to Uranus.

Uranus: proxy for exoplanet research

Uranus also serves as a proxy for studying the nearly 2,000 similarly sized exoplanets discovered in the past few decades. this “exoplanet ‘In our backyard’ helps astronomers understand how planets of this size work, what their meteorology is like and how they formed Masu. This helps us understand our own solar system as a whole by placing it in a larger context.

The James Webb Space Telescope is the world’s highest space science observatory. Webb unravels the mysteries of our solar system, looks to distant worlds around other stars, and explores the mysterious structure and origins of our universe and our place in it. Webb is an international program led by: NASA With our partner ESA (european space agency) and the Canadian Space Agency.


Source: scitechdaily.com

Groundbreaking Model Opens Doors to Remarkable Drug Discoveries

Researchers have made significant progress in understanding neuromuscular diseases by developing a two-dimensional neuromuscular junction model using pluripotent stem cells. This model enables high-throughput drug screening and complements previously developed three-dimensional organoids. (Artist’s concept) Credit: SciTechDaily.com

Scientists have developed a groundbreaking two-dimensional model to study neuromuscular diseases. This has enabled efficient drug testing and improved our understanding of diseases such as spinal muscular atrophy and amyotrophic lateral sclerosis.

Researchers have so far identified about 800 different neuromuscular diseases. These conditions are caused by problems with how muscle cells, motor neurons, and peripheral cells interact. These diseases, such as amyotrophic lateral sclerosis and spinal muscular atrophy, can cause muscle weakness, paralysis, and even death.

“These diseases are very complex and the causes of dysfunction are diverse,” said Dr. Mina Gouti, head of the Max Delbrück Center’s Developmental Stem Cell Modeling and Disease Laboratory. The problem could be in the neurons, the muscle cells, or the connections between the two. “To better understand the causes and find effective treatments, we need human-specific cell culture models that allow us to study how motor neurons in the spinal cord interact with muscle cells.”

Innovative research using organoids

Researchers working with Gouti had already developed a three-dimensional neuromuscular organoid (NMO) system. “One of our goals is to use our cultures for large-scale drug testing,” Gouti says. “Three-dimensional organoids are so large that they cannot be cultured for long periods of time in the 96-well culture dishes we use to conduct high-throughput drug screening studies.”

Human self-assembling 2D neuromuscular junction model. Immunofluorescence analysis of the whole dish shows myocytes (magenta) organized into bundles surrounded by spinal neurons (cyan). Credit: Alessia Urzi, Max Delbrück Center

For this type of screening, an international team led by Gouti has now developed a self-organizing neuromuscular junction model using pluripotent stem cells. The model includes neurons, muscle cells, and chemicals. synapse It is called the neuromuscular junction, which is necessary for two types of cells to interact. The researchers have now published their findings in the journal. nature communications.

“The 2D self-assembled neuromuscular junction model allows us to perform high-throughput drug screening for various neuromuscular diseases and study the most promising candidates in patient-specific organoids,” says Gouti. .

2D neuromuscular model development

To establish a 2D self-organizing neuromuscular junction model, the researchers first needed to understand how motor neurons and muscle cells develop in the embryo. Although Minas’ team does not conduct embryo research themselves, they use a variety of human stem cell lines and induced pluripotent stem cell lines (iPSCs), which are allowed for research purposes under strict guidelines.

“We tested several hypotheses. We found that the cell type required for functional neuromuscular connections is derived from neuromesodermal progenitor cells,” says doctoral student and author of the paper. says lead author Alessia Urzi.

Urji discovered the right combination of signaling molecules that allow human stem cells to mature into functional motor neurons and muscle cells, and the necessary connections between them. “It was very exciting to see muscle cells contracting under the microscope,” Urji says. “That was a clear sign that we were on the right path.”

Another observation was that upon differentiation, cells organized into regions containing muscle cells and nerve cells, rather like a mosaic.

Optogenetic advances in neuromuscular research

Myocytes grown in culture dishes contract spontaneously as a result of their connections with neurons, but without any meaningful rhythm. Urji and Guti wanted to solve it. In collaboration with researchers at the Charité University of Berlin, they used optogenetics to activate motor neurons. Neurons activated by the flash of light fire and contract muscle cells in synchrony, causing them to move in a way that mimics the physiological conditions of an organism.

Modeling and testing for spinal muscular atrophy

To test the effectiveness of the model, Professor Urji used human iPSCs taken from patients with spinal muscular atrophy. Spinal muscular atrophy is a serious neuromuscular disease that affects children during their first year of life. Neuromuscular cultures generated from patient-specific induced pluripotent stem cells showed severe problems with muscle contraction similar to the patient’s disease state.

For Gooty, 2D and 3D cultures are important tools to study neuromuscular diseases in more detail and test more efficient and personalized treatment options. As a next step, Gouti and her team hope to conduct high-throughput drug screens to identify new treatments for patients with spinal muscular atrophy and amyotrophic lateral sclerosis. “We want to start by using new drug combinations to see if we can achieve more successful outcomes to improve the lives of patients with complex neuromuscular diseases. ” says Gooty.

Reference: “Efficient Generation of Self-Assembling Neuromuscular Junction Models from Human Pluripotent Stem Cells,” Alessia Urzi et al., December 19, 2023. Nature Communications.
DOI: 10.1038/s41467-023-43781-3

Source: scitechdaily.com

DeepMind AI integrates fact checker to make groundbreaking mathematical findings

DeepMind’s FunSearch AI can tackle mathematical problems

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Google DeepMind claims to have made the first ever scientific discovery in an AI chatbot by building a fact checker that filters out useless output and leaves behind only reliable solutions to mathematical or computing problems. Masu.

DeepMind’s previous achievements, such as using AI to predict the weather or the shape of proteins, rely on models created specifically for the task at hand and trained on accurate, specific data. I did. Large-scale language models (LLMs), such as GPT-4 and Google’s Gemini, are instead trained on vast amounts of disparate data, yielding a wide range of capabilities. However, this approach is also susceptible to “hallucinations,” which refers to researchers producing erroneous output.

Gemini, released earlier this month, has already shown hallucination tendencies and even gained simple facts such as: This year’s Oscar winners were wrong. Google’s previous AI-powered search engine even had errors in its self-launched advertising materials.

One common fix for this phenomenon is to add a layer on top of the AI ​​that validates the accuracy of the output before passing it on to the user. However, given the wide range of topics that chatbots may be asked about, creating a comprehensive safety net is a very difficult task.

Al-Hussein Fawzi Google’s DeepMind and his colleagues created a general-purpose LLM called FunSearch based on Google’s PaLM2 model with a fact-checking layer they call an “evaluator.” Although this model is constrained by providing computer code that solves problems in mathematics and computer science, DeepMind says this work is important because these new ideas and solutions are inherently quickly verifiable. is a much more manageable task.

The underlying AI may still hallucinate and provide inaccurate or misleading results, but the evaluator filters out erroneous outputs, leaving only reliable and potentially useful concepts. .

“We believe that probably 90% of what LLM outputs is useless,” Fawzi says. “If you have a potential solution, it’s very easy to tell whether this is actually the correct solution and evaluate that solution, but it’s very difficult to actually come up with a solution. So , mathematics and computer science are a particularly good fit.”

DeepMind claims the model can generate new scientific knowledge and ideas, something no LLM has ever done before.

First, FunSearch is given a problem and a very basic solution in the source code as input, and then generates a database of new solutions that are checked for accuracy by evaluators. The best reliable solutions are returned as input to the LLM with prompts to improve the idea. According to DeepMind, the system generates millions of potential solutions and eventually converges on an efficient result, sometimes even exceeding the best known solution.

For mathematical problems, a model creates a computer program that can find a solution, rather than trying to solve the problem directly.

Fawzi and his colleagues challenged FunSearch to find a solution to the cap set problem. This involves determining the pattern of points where three points do not form a straight line. As the number of points increases, the computational complexity of the problem increases rapidly. The AI ​​discovered a solution consisting of 512 points in eight dimensions, larger than previously known.

When tackling the problem of bin packing, where the goal is to efficiently place objects of different sizes into containers, FunSearch discovered a solution that outperformed commonly used algorithms. The result is a result that can be immediately applied to transportation and logistics companies. DeepMind says FunSearch could lead to improvements in more math and computing problems.

mark lee The next breakthrough in AI will not be in scaling up LLM to ever-larger sizes, but in adding a layer to ensure accuracy, as DeepMind has done with FunSearch, say researchers at the University of Birmingham, UK. It is said that it will come from.

“The strength of language models is their ability to imagine things, but the problem is their illusions,” Lee says. “And this study breaks that down, curbs that, and confirms the facts. It’s a nice idea.”

Lee says AI should not be criticized for producing large amounts of inaccurate or useless output. This is similar to how human mathematicians and scientists work: brainstorm ideas, test them, and follow up on the best while discarding the worst.

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Source: www.newscientist.com

Unprecedented Level of Internal Structure Exposed by Groundbreaking Human Brain ‘Atlas’

Global collaboration has led to the creation of the world’s most comprehensive primate brain atlas, consisting of 4.2 million cells. This atlas has provided insights into region-specific functions, associations with neurological diseases, and has guided future brain research and disease intervention. The project aims to explore the evolution of the human brain and discover new targets for disease treatment. The initiative, known as the “Brain Initiative Cell Census Network” project by the National Institutes of Health, has been working towards mapping the cell groups and understanding their functions for over 21 years. The recent breakthrough discovery has allowed scientists to gain a deeper understanding of the brain and the medical mysteries behind disorders such as autism and depression. The research team, led by scientists from Arizona State University, the University of Pennsylvania, the University of Washington, and the Brotman Beatty Institute, created the largest atlas of the primate brain to date. The atlas consists of profiles of over 4 million cells, providing valuable information on the evolution of human cognition and behavior, as well as the occurrence of neurological diseases. The data collected has been made publicly available for the scientific community and the general public. The research team utilized state-of-the-art single-cell techniques and analyzed gene expression and DNA regulatory regions to identify molecularly distinct brain cell types and their functional characteristics. They also investigated the genetic architecture of neurological disease risk at the cellular level. The atlas serves as a crucial resource for further research on the human brain and potential interventions for neurological diseases.

Source: scitechdaily.com