Tag Archives: medication

New York County Clerk refuses to accept Texas Court filings targeting doctors over abortion medication

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The New York County Clerk recently prevented Texas doctors from taking legal action against New York doctors to provide abortion pills to Texas women.

This groundbreaking decision escalates the interstate abortion conflict to a new level, setting the stage for a legal showdown between states with differing views on abortion rights.

The dispute is expected to reach the Supreme Court, pitting Texas against New York. Texas has almost completely banned abortion. New York, on the other hand, has a Shield Law in place to protect abortion providers who supply medications to patients in other states.

Since the Supreme Court overturned the national abortion right in 2022, eight states, including New York, have implemented the Telehealth Abortion Shield Act. This law prohibits authorities from surrendering abortion providers to other states or complying with legal actions such as subpoenas.

The New York County Clerk’s action marks the first use of the Abortion Shield Act to oppose out-of-state judgments.

Dr. Margaret Daly Carpenter, based in New Paltz, New York, is involved in this case. She collaborates with telehealth abortion organizations to provide abortion medications nationally. Texas Attorney General Ken Paxton sued Dr. Carpenter in December for allegedly sending abortion pills to Texan women in violation of the state’s ban.

Dr. Carpenter and her legal team did not appear at a Texas court hearing last month. Consequently, Collin County District Court Judge Brian Gant issued a default ruling, imposing a $113,000 fine on Dr. Carpenter and mandating the sending of abortion pills to Texas.

Citing the New York Shield Act, Ulster County’s Deputy Clerk Taylor Brook refused to process Texas’ motion for enforcing the Collin County order. He also declined to file a subpoena demanding payment of the penalty and compliance with the Texas ruling.

“In accordance with the New York State Shield Act, I reject this submission and any similar future submissions,” Brooke stated in a release. “This decision may lead to additional legal action, and we must refrain from discussing specific case details at this time.”

Texas Attorney General Paxton has vowed to continue his efforts. He criticized New York for not cooperating in enforcing civil judgments against abortion providers who allegedly cross state lines with dangerous drugs.

Legal experts anticipate that Texas may challenge the Shield Act in New York state or federal courts next.

New York Attorney General Letitia James previously issued guidance to courts and officials statewide on adhering to the Shield Act’s requirements and restrictions.

“I commend the Ulster County Clerk for upholding the law,” James declared. “The New York Shield Act safeguards patients and providers from out-of-state attacks on reproductive rights. We must not allow anyone to hinder healthcare professionals from delivering essential care to patients. My office will always stand with New York healthcare providers and the individuals they serve.”

Texas became the first state to take legal action against abortion providers from other states using Shield laws. In a separate case, Louisiana also filed criminal charges against a Shield Act abortion provider earlier this year.

In the recent past, Louisiana officials requested Dr. Carpenter’s extradition, a request that New York Governor Kathy Hochul promptly rejected.

“We will not authorize the extradition request from the Louisiana governor,” affirmed Hochul.

Dr. Carpenter and her legal team have refrained from commenting on the Texas and Louisiana cases. The Abortion Alliance for Telemedicine, an organization co-founded by Dr. Carpenter, issued a statement expressing support for the Shield Act. “The Shield Act is crucial in ensuring access to abortion care regardless of location or financial status,” the coalition emphasized. “It upholds the fundamental right to reproductive healthcare for all individuals.”

The Telemedicine Abortion Shield Act has become a vital tool for advocates of abortion rights. Health providers in states where abortion is legal send over 10,000 abortion medications each month to patients in states with restrictive laws.

The Texas lawsuit against Dr. Carpenter accuses her of providing a 20-year-old woman with mifepristone and misoprostol, standard abortion medications used up to 12 weeks into pregnancy. Mifepristone blocks necessary pregnancy hormones, while misoprostol induces contractions akin to a miscarriage 24-48 hours later.

According to a complaint from the Texas Attorney General’s office, a woman nine weeks pregnant sought emergency care in July due to bleeding. The woman’s partner suspected that the miscarriage was induced by the woman’s mother and found abortion medications provided by Carpenter at their home.

During a court session in Colin County, Ernest C. Garcia from the Texas Attorney General’s Office revealed that the woman’s partner had lodged a complaint.

Source: www.nytimes.com

The Increased Importance of Exercise with Weight Loss Medication

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For decades, traditional wisdom has believed that in order to lose weight, you have to eat less and move more. Of course, that’s easier said than done. That’s why drugs like Wegovy are so innovative. By suppressing appetite, they help to tackle the first part of the equation, which usually leads to dramatic weight loss. But what about the second one? If weight loss pills are reducing the number of scales, should we still head to the gym? And how do these drugs affect our athletic ability?

What has become clear is that it may be even more important for those taking these medications than those who don’t. The ability of semaglutide to induce rapid weight loss (see “How do they work?” below) also leads to a significant decrease in muscle mass. For example, a 2021 study of 95 people who were overweight or obese taking semaglutide found that their lean body mass was reduced by almost 10% on average, 68 weeks later.

This article is part of a special series investigating the GLP-1 agonist boom. Click here for details.

Lean body weight covers body tissues such as muscles and bones. Therefore, these results suggest that both are affected when taking weight loss medications, Signee Sørensen Torekov at the University of Copenhagen explains. These drugs guide people to burn fewer calories, so the body needs to break down fat, muscle, and even bones for nutrients.

“Our understanding is that up to about 40% of the overall weight loss seen in semaglutide is thought to be due to the loss of muscle mass,” he said.

Source: www.newscientist.com

What is the best time to take cancer medication?

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Every year, scientists around the world offer research to cancer treatment. What if the answer is related to the time when cancer patients are taking medicine? Group of German scientists wanted to find out if a 24 -hour clock of the body was also known as itself. Approximately rhythmIt can affect the fight against cancer.

To test their hypothesis, scientists monitor how cancer cells behave with various drugs at various times. First, they collected a variety of cells from human milk cancer patients, including some healthy tissue cells and several tumor cells. They thoroughly monitored cell characteristics such as growth, drug reactions, and outline rhythm strength. They explained that the intensity of the rhythm of the day refers to cells that usually change the movement determined by the day and night cycle.

Scientists used the method called to determine the rhythmic intensity. Self -correlationWe measured how cells work at different times. They used the second method to identify the dominant frequency and time of the cellular signal. Continuous wavelength conversion。 They use this method to break down the signals into small parts, each represents different frequencies and time range.

Finally, they use another method to simultaneously look at both large and small cell processes and further disassemble the signals called. Multi -election analysis。 By combining these methods, we measured how the drug affected the growth of cells over time, and identified what has changed based on time -dependent or dunning effects.

Researchers have grown a group of special breast cancer cells, which are known to have biological watches incorporated in the controlled environment. They added drugs to fight a variety of cancers at different times of the day, and evaluated how they changed their effectiveness. They also administered a variety of drugs and found the best dosage for their daily time. In order to test how the cells react over time, the cell growth rate was measured by imaging with a microscope and growing fast under various conditions. Later, scientists organized cells and drugs into groups based on how they responded to the test.

In addition, researchers conducted tests to measure the efficiency of the administered drugs. First, we used a series of light dark cycle to synchronize the cells to a specific outline. Later, they used live cell imaging to monitor cell growth and survival, and administer drugs at a different period of one day, exceeding four hours. After that, the team compared the way cells react to drugs on various occasions and identified the best time to administer drugs for cancer treatment. Scientists have discovered a strong correlation between the aid clock and drugs.

In order to explore the influence of the outline clocks on cell treatment, scientists also tested the overall contribution of each gene component in cells to the overall drug reaction. They explained that the gene of our body decides how well the drug can suppress cancer and how strongly it can accept the drug. However, with almost 20,000 gene, scientists want to match each drug to the most effective target gene.

To do this, the team used two methods to collect very large datasets and create called forecasts. Linear discrimination analysis and Main ingredient analysis。 They used these methods to rank the cell gene according to how effectively the cells react to drugs, and identify the mutant pattern between gene. They discovered that different genes show different sensitivity to each drug.

Scientists concluded that the rhythm of the solar cells affects drug sensitivity and effectiveness. They suggested that future workers test other undeveloped gene and confirm that they are sensitive to specific cancer drugs. The team concluded that their results would help scientists to understand how the 24 -hour cycle of the body would affect cancer treatment, which is sensitive to time.


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Source: sciworthy.com

Research shows new medication similar to Ozempic results in 13% reduction in body weight

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Weight-loss medications like Ozempic and Wegovy have been under discussion for some time, but new research suggests there may be better alternatives. Enter Amicretin, a novel weight-loss treatment available in pill form rather than injection.

In the initial human trials of this new weight loss medication, the developer Novo Nordisk A/S (the company behind Ozempic) saw promising results: participants taking Amicretin lost an average of 13.1 percent of their body weight over a 12-week period.

So, how does this new weight loss pill function? Amicretin is a dual-acting drug that emulates the effects of two hormones crucial in weight loss: amylin and glucagon-like peptide-1 (GLP-1), which help curb hunger and regulate appetite.

Published in the journal Diabetology, the study compared average weight loss in three groups with BMIs between 25 and 39.9 who did not have diabetes.

By the end of the 12-week study, subjects taking two 50 mg tablets of Amicretin lost 13.1% of their body weight, compared to 10.4% in those taking one 50 mg tablet. In contrast, the placebo group only lost an average of 1.1% of their body weight throughout the study.

Compared to other weight loss drugs, a recent study in JAMA Internal Medicine found that patients taking another weight-loss drug, Maunjaro, lost 5.9% body fat in 3 months, while those on Ozempic saw a decrease of 3.6%.

“The difference from injectable treatments is significant,” states obesity expert Christopher Clemmensen. “The dual mode of action offers promise, making Amicretin a valuable advancement for Novo Nordisk.”

While weight-loss drugs show promise in combating obesity worldwide, further confirmation awaits larger trials on individuals with chronic conditions. Professor Navid Sattar emphasizes the importance of developing safe and accessible medications for the millions suffering from obesity.

Excitement surrounds this early-stage study of a novel oral weight-loss medication combination due to its rapid effects on body weight.

About our experts

Associate Professor Christopher Clemmensen leads the Clemmensen Group at the University of Copenhagen, studying biological weight regulation and developing obesity treatment strategies. His research appears in respected publications such as Natural Metabolism and Molecular Metabolism.

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Source: www.sciencefocus.com

Anti-inflammatory medication increases mice’s lifespan by 20%

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Inflammatory molecules (green) are found in liver tissue from aged mice.

Anissa A. Wijaya et al. 2024

Blocking an inflammatory molecule known as interleukin-11 (IL-11) extends the lifespan of mice, suggesting that drugs that block IL-11 may have anti-ageing effects in humans.

As we age, damage accumulates in our cells, triggering our immune system to release inflammatory molecules such as IL-11. While low levels of inflammation can protect us from disease and injury, excessive inflammation damages cells and is thought to accelerate aging.

“It's like pouring gasoline on a fire.” Stuart Cook Research from Duke-NUS Medical School in Singapore suggests that reducing inflammation could help slow the decline in health that comes with aging.

To test this idea, Cook and his colleagues injected 37 mice with a drug that uses antibodies to block IL-11. The mice received injections every three weeks from the age of 75 weeks (equivalent to about 55 years in humans) until they died. Another group of 38 mice received a different antibody therapy that did not target IL-11.

The researchers found that blocking IL-11 extended the lifespan of both male and female mice by more than 20 percent, and in further experiments, animals that received anti-IL-11 therapy were less likely to develop cancer: fewer than 16 percent of treated rodents had tumors, compared with more than 60 percent of controls.

The therapy also reduced cholesterol levels, frailty and body weight, and improved muscle strength and metabolism in the treated animals. Together, these findings suggest that blocking IL-11 may ameliorate age-related decline in health and extend lifespan in mice.

But until clinical trials are conducted, Cook says it won't be clear whether the same is true in humans. Although several trials are underway testing anti-IL-11 therapies in people with certain inflammatory diseases, such as pulmonary fibrosis, none are investigating their potential anti-aging effects, he said.

It's also important to remember that some inflammation is normal as we age. Shilpa Ravella Speaking at Columbia University in New York, she says the difficulty lies in knowing who might benefit from this type of anti-inflammatory therapy.

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Source: www.newscientist.com

Adopting a low FODMAP diet may be more effective than medication in reducing symptoms of irritable bowel syndrome

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Eating less of some types of foods and more of others may ease irritable bowel syndrome

Aamrya/Getty Images

Two types of diets are more effective at treating irritable bowel syndrome (IBS) than drugs, a trial has found.

One diet was designed to be low in FODMAPs, a group of carbohydrates similar to sugars found in dairy products, wheat, and certain fruits and vegetables. The second, less common approach used for IBS is an adaptation of a low-carbohydrate diet that is high in fiber and low in other types of carbohydrates, such as sugar and starch.

In a randomized trial, both diets showed better symptom improvement than standard drug treatment after four weeks.

IBS can cause mysterious symptoms such as diarrhea, constipation, bloating, and abdominal pain that increase or decrease over time. The underlying cause of this condition is unknown.

The usual advice is to avoid common triggers such as caffeine, alcohol and spicy foods. Symptomatic treatments such as laxatives for constipation and drug therapy for diarrhea may be given.

If these measures don’t work, you may want to consider cutting back on foods high in FODMAPs. FODMAPs tend not to be digested until they reach the colon, which is why they are thought to cause bloating and diarrhea. This encourages the colon to retain water, and when the molecules are consumed by bacteria, gas is produced and causes bloating.

Sanna Niebacka Researchers from the University of Gothenburg in Sweden wanted to find out how a regular low-FODMAP diet compared to an alternative approach: high in fiber but low in carbohydrates. In practice, this means eating high-fat, high-protein foods such as meat and dairy products, and sources of fiber include nuts, seeds, beans, and vegetables such as cabbage.

The research team asked around 300 people with IBS to use one of three approaches depending on their symptoms: take medication or adopt one of two diets. The diet provided people with free grocery delivery, as well as detailed meal plans and recipes.

After one month, 76% of the low-FODMAP group reported a significant reduction in symptoms, compared with 71% of the low-carbohydrate diet group and 58% of the drug treatment group.

The big surprise was that a low-carbohydrate, high-fiber diet that didn’t exclude FODMAP-containing foods was about as effective as a low-FODMAP approach, Nybacka says. “We can’t answer any questions as to why. It appears that altering carbohydrate content and reducing FODMAP intake may be beneficial.”

but hazel everitt Researchers at the University of Southampton in the UK say the trial would have been more informative if it had lasted longer. “The problem with many of the IBS diets that have been proposed is that they are very difficult to stick to long-term,” she says.

Participants were followed for up to six months, but during the last five months participants who were initially offered drug treatment were also given dietary advice.

Niebacka says one potential problem with the low-carbohydrate, high-fiber diet is that this group of people had slightly elevated blood cholesterol levels. Therefore, you should seek your doctor’s advice before adopting this diet, she says.

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Source: www.newscientist.com

ADHD Medication Errors in US Children Skyrocket with Alarming 300% Jump

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Medication errors in children with ADHD have increased dramatically, with the majority occurring at home and involving males between the ages of 6 and 12, a study has found. Enhanced education and improved medication management are needed to reduce these errors. Credit: SciTechDaily.com

Experts call for patient and caregiver education and the development of improved dosing and tracking systems that are tolerable in children.

attention-deficit/hyperactivity disorder (ADHD) is one of the most common childhood neurodevelopmental disorders. In 2019, nearly 10% of children in the United States were diagnosed with ADHD. Currently, about 3.3 million children in the United States, or about 5 in 100 children, are prescribed her ADHD medication.

Increase in ADHD medication errors

In a new study recently published in the journal Pediatricsresearchers from Nationwide Children’s Hospital’s Center for Injury Research and Policy and the Central Ohio Poison Center, investigated the characteristics and characteristics of out-of-hospital ADHD medication errors reported to U.S. poison centers from 2000 to 2021 in people under age 20. We investigated trends.

According to the study, the annual number of ADHD-related medication errors increased by 299% from 2000 to 2021. During the study period, 87,691 medication error incidents involving ADHD medications as the primary substance in this age group were reported to U.S. poison centers. An average of 3,985 individuals are born per year. In 2021 alone, he was reported for 5,235 medication errors, which equates to 1 child for every 100 minutes he received. The overall trend was that males accounted for 76% of medication errors and the 6-12 year age group accounted for 67% of medication errors. Approximately 93% of exposures occurred in the home.

Common medication error scenarios

Among medication errors involving ADHD medications as the primary substance, the most common scenarios include:

  • 54% – “I accidentally took or administered my medication twice.”
  • 13% – “I accidentally took or gave someone else’s medication.”
  • 13% – “I took/administered the wrong medication.”

“The increase in the number of reported medication errors is consistent with the findings of other studies that have reported an increase in the number of ADHD diagnoses among children in the United States over the past two decades, which reflects the use of ADHD medications. “It is likely associated with an increase in

Health effects and prevention strategies

In 83% of cases, the person was not receiving treatment in a health facility. However, 2.3% of cases were admitted to a health care facility, of which 0.8% were admitted to a critical care unit. Additionally, 4.2% of cases were associated with serious medical outcomes. Some children experienced agitation, tremors, seizures, and changes in mental status. Children under 6 years of age were twice as likely to experience a serious medical outcome and more than three times as likely to be admitted to a health care facility compared to children aged 6 to 19 years.

“Because medication errors in ADHD are preventable, more attention needs to be paid to educating patients and caregivers and developing improved medication and tracking systems that are resistant to children,” said the study’s senior author. said Center Director Gary Smith, MD, PhD. Contributes to injury research and policy at Nationwide Children’s Hospital. “Another strategy could be a move away from pill bottles to unit-dose packaging, such as blister packs, which could help people remember if a drug has already been taken or administered.”

Prevention efforts should focus on the home, but additional attention should also be paid to schools and other settings where children and adolescents spend time or receive medications.

References: “Pediatric ADHD Medication Errors Reported to U.S. Poison Centers from 2000 to 2021” Mikaela M. DeCoster, BS; Henry A. Spiller, MS, D.ABAT; Jaahnavi Badeti, MPH, BDS. Marcel J. Casavant, MD. Natalie I. Rein, Pharm.D., BCPS, BCCCP. Dr. Nicole L. Michaels. Motao Zhu, MD, MS, PhD. Gary A. Smith, MD, PhD, September 18, 2023; Pediatrics.
DOI: 10.1542/peds.2023-061942

Data for this study were obtained from the National Poison Data System (NPDS) maintained by the American Poison Centers (formerly the American Association of Poison Control Centers (AAPCC)). Poison Centers receive calls through the National Poison Helpline (1-800-222-1222) and document and report information to NPDS about the product, route of exposure, exposed individuals, exposure scenario, and other data.

Source: scitechdaily.com