Why Intermittent Fasting May Not Be Effective for Weight Loss

Intermittent Fasting: A Closer Look at Its Effectiveness for Weight Loss

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Recent studies indicate that intermittent fasting may not be as effective for weight loss as previously thought, raising questions about its efficacy compared to other dieting methods.

Intermittent fasting has gained popularity as a weight management strategy, characterized by alternating fasting and eating periods. Popular methods include the 16:8 approach, which involves fasting for 16 hours and consuming food within an 8-hour window, and the 5:2 diet, where normal eating occurs for five days, followed by a significant calorie restriction on two days.

The hypothesis behind intermittent fasting is that it will lead to reduced caloric intake. However, a recent randomized controlled trial showed no significant difference in weight loss when compared to traditional calorie-counting methods.

In a comprehensive analysis led by Luis Garegnani, researchers from the Buenos Aires Italian Hospital reviewed data from 22 randomized controlled trials involving approximately 2,000 overweight or obese adults from regions including North America, Europe, China, Australia, and South America. Participants aged 18 to 80 were included in the study.

The results suggested that there was likely no significant difference in weight loss when comparing intermittent fasting to established dietary practices. Furthermore, when placed against a control group doing nothing, intermittent fasting showed similar results. “Intermittent fasting does not appear effective for individuals struggling to lose weight,” Garegnani stated in a press release.

Despite these findings, variability among trials complicates definitive conclusions. Nonetheless, when results were segmented by gender or by the type of intermittent fasting practiced, the overall effectiveness for weight loss remained questionable.

Furthermore, Satchidananda Panda from California’s Salk Institute for Biological Studies emphasized that many trials included in this review did not accurately monitor participants’ adherence to intermittent fasting protocols. He remarked, “What are we analyzing if we don’t even know if participants followed the fasting guidelines?”

Since the primary focus of this analysis was weight loss, it remains unclear if intermittent fasting offers additional health benefits or negative consequences. Some studies propose that it may elevate heart disease risk, while others suggest potential improvements in immunity and liver and gut health.

“Intermittent fasting should not be viewed as a panacea,” Garegnani concluded. “While it may serve as a strategy for some, it should complement broader public health initiatives aimed at combating obesity.”

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Source: www.newscientist.com

Weather Update from Titan, Saturn’s Moon: Partly Cloudy with Intermittent Methane Rain

With data from the NASA/ESA/CSA James Webb Space Telescope and the Keck II telescope, astronomers have found signs of cloud convection in Titan’s northern hemisphere. The majority of Titan’s lakes and oceans are situated in this region, replenished by sporadic rains of methane and ethane. Webb has also identified essential carbon-containing molecules that offer insight into Titan’s intricate atmospheric chemical processes.



These Titan images taken by Webb on July 11, 2023 show the Keck II telescope on July 14, 2023 (lower row), showing methane clouds (white arrows) appearing at various altitudes in Titan’s northern hemisphere. Image credit: NASA/ESA/CSA/STSCI/KECK Observatory.

Titan is a fascinating world enveloped in a yellowish smog haze. Its atmosphere, primarily composed of nitrogen, experiences weather patterns similar to those on Earth, such as clouds and rain.

In contrast to Earth, where weather is influenced by the evaporation and condensation of water, Titan’s chilly environment features a methane cycle.

Methane evaporates from the surface, rising into the atmosphere to condense into clouds.

Occasionally, icy particles fall to solid surfaces as a form of cold, oily rain.

“The Goddard Space Flight Center involves astronomers,” stated Dr. Connn Nixon, an astronomer at NASA’s Goddard Space Flight Center.

Utilizing both Webb and Keck II telescopes, Dr. Nixon and his team observed Titan in November 2022 and July 2023.

These observations revealed cloud formations in the northern and high northern latitudes of Titan, coinciding with its current summer, and indicated that these clouds were gradually rising to higher altitudes.

Previous research identified cloud convection in southern latitudes, marking the first evidence of similar convection in the northern hemisphere.

This finding is crucial, as most of Titan’s lakes and oceans are located in the northern hemisphere, making evaporation from these bodies of water a primary source for methane.

On Earth, the troposphere, the lowest atmospheric layer, extends to about 12 km in altitude.

However, due to Titan’s low gravity, its troposphere stretches to approximately 45 km.

By utilizing various infrared filters, Webb and Keck explored different atmospheric depths on Titan, enabling astronomers to estimate cloud altitudes.

Researchers noted that clouds seemed to migrate to higher altitudes over a few days, although direct observation of precipitation remains elusive.

“Webb’s observation occurred at the end of Titan’s summer, a season we couldn’t monitor during the NASA/ESA Cassini-Huygens mission,” remarked ESA researcher Dr. Thomas Cornet.

“Combined with ground-based observations, Webb is providing us with valuable new insights into Titan’s atmosphere. This ESA mission could explore the Saturn system in greater detail in the future.”

Titan is of significant astrobiological interest due to its intricate organic (carbon-containing) chemistry, despite its frigid temperatures of minus 180 degrees Celsius.

Organic molecules are the building blocks of life on Earth, and studying them in an environment like Titan may help scientists uncover the processes that contributed to the emergence of life on our planet.

Methane serves as a fundamental component driving much of Titan’s chemistry.

In Titan’s atmosphere, methane is broken down by sunlight or energetic electrons from Saturn’s magnetosphere, leading to the synthesis of ethane-like substances alongside more complex carbon-containing molecules.

The data from Webb provided a crucial missing piece for comprehending these chemical processes: the definitive detection of methyl radicals (CH)3, which form when methane breaks apart.

Identifying this compound signifies that scientists can now observe chemical reactions occurring on Titan for the first time, not just the initial ingredients or the end products.

“We are very enthusiastic about this world,” said Dr. Stephanie Millam, a researcher at NASA’s Goddard Space Flight Center.

This hydrocarbon chemistry will have lasting implications for Titan’s future.

As methane decomposes in the upper atmosphere, some of it recombines to form other molecules, eventually reaching Titan’s surface in one chemical form or another, while some hydrogen escapes into space.

As a result, methane reserves will diminish over time unless there is a source to replenish them.

A similar phenomenon has occurred on Mars, where water molecules were broken down, and the resulting hydrogen was lost to space, culminating in the arid desert planet we observe today.

“In Titan, methane is continuously consumable,” Dr. Nixon explained.

“It could be constantly replenished from the crust and interior for billions of years.”

“If not, eventually it will all disappear, leaving Titan as a desolate landscape of dust and dunes.”

These findings were published in the journal Natural Astronomy.

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Kanixon et al. The atmosphere of Titan in late northern summer from JWST and Keck’s observations. Nature Astronomy Published online on May 14th, 2025. doi:10.1038/s41550-025-02537-3

Source: www.sci.news

Incredible Ways Body Fat Affects Your Intermittent Fasting Experience

Intermittent fasting has emerged as a popular approach to enhance health and boost metabolism. However, recent research indicates that its advantages may be diminished by body fat due to inconspicuous disruptions in the liver’s hunger adaptation.

In a study, researchers assessed liver modifications in both healthy and obese mice that lacked leptin, the hormone responsible for regulating appetite, during food deprivation periods. Intermittent fasting entails extended calorie restriction followed by a regular eating window.

Both mouse groups exhibited similar metabolic networks, comprising liver molecules that collaboratively manage energy; however, significant differences in timing were observed.

“In a healthy liver, energy-centric molecules such as adenosine triphosphate (ATP) and adenosine monophosphate (AMP) quickly respond to starvation and modulate various metabolic reactions,” stated Professor Shinya Kuroda in BBC Science Focus.

“This mechanism appears to be deficient and confused in obese individuals.”

To put it differently, in healthy mice, energy-related molecules like ATP and AMP operate as primary hubs, swiftly adapting metabolic responses to conserve and redistribute energy. Conversely, in obese mice, these molecules did not exhibit a quick response, resulting in a sluggish and disoriented reaction to starvation.

A rapid response from ATP and AMP during periods of food scarcity enables the liver to utilize energy from stored reserves. This process is believed to facilitate several benefits of intermittent fasting, such as weight reduction and better glycemic control.

Through a combination of structural and temporal metabolic analyses, the research team elucidates how obesity induces metabolic “jet lag,” complicating not just the timing but also the manner in which crucial molecular events transpire.

“Our findings could have significant implications for enhancing the effectiveness of intermittent fasting in humans,” Kuroda remarked.

“Next, we aim to identify easily detectable blood-based biomarkers in humans,” Kuroda added. “Ultimately, clinical research is necessary to assess our findings. The journey is lengthy, but every thousand-mile journey begins with a single step.”

This research was published in Science Signaling.

About Our Experts

Shinya Kuroda is a professor at the Faculty of Science at the University of Tokyo, Japan, focusing on Systems Biology. His research includes publications in Cell, Journal of Biochemistry, and Natural Cell Biology.

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Source: www.sciencefocus.com

New study suggests simple diet hacks are more effective than intermittent fasting for weight loss

A bowl of warm pasta, a fluffy white bread roll, or a bag of generously salted chips – these starchy delights are like dreams. No wonder many of us couldn’t imagine giving up carbs forever.

But according to Research by the University of Surrey, spending just one day without carbohydrates has a similar effect on the body as intermittent fasting.

Intermittent fasting, also known as time-limited feeding, involves alternating normal feeding periods with significantly reduced calorie intake periods. These fasting windows can be scheduled at specific times each day or throughout the week.

While this approach has various health benefits, consuming less than 800 calories a day, as recommended on the popular 5:2 diet, can be challenging for some individuals.

However, this new study suggests that reducing calories significantly on fasting days may not be necessary. Simply cutting out carbohydrates can provide similar fat-burning benefits.

“What we’re interested in is not necessarily weight loss, but the metabolic effect of this dietary intervention,” said Dr. Adam Collins, the study co-author and an associate professor of nutrition at the University of Surrey, in an interview with BBC Science Focus.

The study, which aimed to investigate the effects of carbohydrates on metabolic health, involved 12 overweight or obese adults aged 20 to 65.

Participants followed three different meal plans with five-day breaks between each diet day for 36 hours (one day and two nights of sleep). The meal plans included a normal meal, a low-carb diet with the same calorie intake as a regular diet, and a low-carb diet with reduced calories.

Results showed that consuming a low-carb diet, regardless of calorie intake, encouraged the body to burn fat for energy similar to a fasting diet.

Carbohydrates include starches such as potatoes and pasta, grains such as rice and oats, baked goods such as bread and pastries, fiber foods such as vegetables and fruits, and sugar confectionery such as sweets and chocolate.

Dr. Collins explained that the body is designed to use carbohydrates for energy after meals and fats between meals and overnight. Consuming carbs too frequently can lead to poor management of metabolism.

Intermittent fasting or reducing carbohydrate intake helps the body reset and start burning fat for energy. Dr. Collins also emphasized that while restricting carbs long-term may hinder glucose processing, alternating low-carb days with regular meal days can be a sustainable and beneficial approach for metabolic health.

He concluded by saying, “Food is not a sin. Carbs aren’t bad. Fats aren’t bad. It’s all about moderation.”

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About our experts:

Dr. Adam Collins: An associate professor of nutrition at the University of Surrey’s School of Biological Sciences. With over 20 years of experience as a qualified nutritionist, he leads BSC and MSC nutrition programs at Sally. His current research focuses on exercise intensity, energy balance, intermittent fasting, dietary timing and composition, and carbohydrate manipulation for metabolic health.

Source: www.sciencefocus.com

Research indicates that intermittent fasting may have a major impact on slowing down hair growth

Intermittent fasting can be effective for weight loss, but it can also have negative effects on hair growth, as shown in a recent mouse experiment conducted by researchers at Westlake University in China. The study found that mice undergoing intermittent fasting experienced improved metabolic health but showed delayed hair regrowth. This link between restrictive eating and hair regrowth was also observed in a study published in Cell.

While similar effects may occur in humans, they are typically less severe due to differences in metabolic rate and hair growth patterns. Nevertheless, it is important to be aware of the potential unintended consequences of intermittent fasting, as highlighted by senior author and stem cell biologist Dr. Bing Zhang.

Further research is needed to fully understand the effects of fasting on hair growth, as current studies have primarily focused on its benefits for blood, muscle tissue supply, and metabolism. The research team at Westlake University conducted experiments on mice to explore the impact of intermittent fasting on hair regrowth, with findings suggesting that prolonged fasting stresses hair follicle stem cells, leading to delayed hair growth.

A small clinical trial involving 49 healthy young individuals showed that time-restricted eating with 18 hours of daily fasting reduced hair growth by an average of 18 percent. However, the researchers caution that the study’s small sample size and short duration may yield different results in larger-scale studies.

Future research will investigate how fasting affects other types of stem cells in the body and its implications for wound healing speed. Despite the potential drawbacks, intermittent fasting remains a popular and beneficial practice for many individuals.

Source: www.sciencefocus.com

Intermittent fasting linked to higher risk of heart disease-related death

Eating within eight hours, commonly known as the 16:8 diet, is a common form of fasting.

Christina Pedrazzini/Science Photo Library/Getty Images

Restricting eating time to eight hours a day (a common type of intermittent fasting) is associated with an increased risk of death from heart disease. However, some scientists believe that people with pre-existing health conditions may unconsciously eat intermittent meals if their symptoms or treatments affect their appetite and perhaps the quality of the meal is more important than the time of the meal. It claims that you may choose to fast.

It has long been reported that time-restricted eating can lead to improvement. blood pressure, Blood glucose level and cholesterol levelbut the long-term effects are unknown.

You can learn more about Chong Wenze Researchers from Shanghai Jiao Tong University in China and their colleagues surveyed about 20,000 adults (almost evenly split between men and women) who took part in the US National Health and Nutrition Examination Survey. Their average age was 49 years, and just under three-quarters were non-Hispanic white.

Each year from 2003 to 2018, study participants self-reported their dietary information. The researchers then matched this with U.S. Centers for Disease Control and Prevention death records from 2003 to 2019. Participants were eligible if they were 20 years of age or older and had completed two dietary questionnaires within one year of the study.

Over an average 8-year follow-up period, the research team found that even though intermittent fasting is often praised, people who ate in an 8-hour window per day were less likely to eat on a 12-hour daily eating schedule. They discovered that they cannot live longer than humans for ~16 hours. For longevity benefits.

Researchers also found that people who followed an eight-hour eating schedule were 91 percent more likely to die from heart disease during the follow-up period than those who ate for 12 to 16 hours or more.

Among people diagnosed with heart disease before the study, those who ate for more than 8 to 10 hours had a 66% higher risk of dying from heart disease than those who ate for more than 12 to 16 hours. Among people diagnosed with cancer, eating for more than 16 hours had a lower risk of dying from cancer than those on a more restrictive eating schedule.

The study, presented at the American Heart Association (AHA) Epidemiology and Prevention Conference in Chicago, does not prove that time-restricted eating caused these deaths, Zhong said. To tell.

They said it was important to consider why participants practiced time-restricted eating. benjamin horn at Intermountain Heart Institute in Salt Lake City, Utah. Some people may have adopted this pattern intentionally, he says, while others may have limited eating windows due to health conditions or treatments that affect their appetite.

He says some people may have restricted eating schedules because of limited access to food. jo ann carson, former chair of the AHA Nutrition Committee. According to research, Food insecurity is linked to unhealthy lifestyles that lead to heart disease. “We also don’t know anything about the health of the food they ate,” Carson said.

The authors acknowledge in their paper that their study relied on self-reported dietary information, which may be inaccurate. They plan to investigate whether this finding applies to a wider range of ethnic groups and how fasting may increase the risk of adverse health outcomes.

People who want to reduce their chances of dying prematurely “should aim for an overall heart-healthy eating pattern, regardless of mealtime,” Carson says. People who want to start intermittent fasting should talk to their doctor first, Horn says.

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Source: www.newscientist.com

Intermittent Fasting Linked to Higher Risk of Cardiovascular Mortality

A recent extensive study involving 20,000 adults discovered that time-restricted eating, a form of intermittent fasting, can significantly increase the risk of death, casting doubt on the efficacy of healthy eating.

The study, published by the American Heart Association, revealed that restricting eating to less than eight hours a day raised the risk of cardiovascular death by an alarming 91%. Over a span of up to 17 years, the study found no decrease in the risk of any specific cause of death by restricting meals to eight hours or less.

Lead author Professor Victor Wenze Zhong expressed surprise at the study’s results, stating, “We had anticipated that adopting an 8-hour time-restricted diet long-term would lead to reduced cardiovascular disease risk and overall mortality.” He added, “Although this diet has been popular for its short-term benefits, our study revealed that compared to the typical 12 to 16-hour eating window, shorter meal times showed no association with living longer.”


Although the reasons behind the increased risk of cardiovascular death from time-restricted eating are not fully understood, it is suggested that muscle mass loss due to dietary restriction may be a contributing factor.

In recent years, time-restricted eating has gained popularity for its potential health benefits, such as aiding weight loss and improving blood sugar and cholesterol levels. Many people follow a 16:8 schedule, consuming all meals within an 8-hour window and fasting for 16 hours.

However, despite short-term benefits, recent findings suggest potential long-term negative effects of time-restricted eating, especially an 8-hour window, on cardiovascular health.

Experts caution that further research is needed to fully understand the impact of time-restricted eating and its implications for long-term health. Specific recommendations regarding time-restricted eating should be made with caution based on current evidence.

About our experts:

Dr. Victor Wenze Zhong is a professor and chair at the School of Medicine, Shanghai Jiao Tong University, specializing in Epidemiology and Biostatistics. He is actively involved in nutritional epidemiology research and serves on various councils related to heart health.

Dr. Christopher Gardner is a professor at Stanford University focusing on the health benefits of different dietary components and patterns. With extensive research in cardiovascular health and nutrition, he provides valuable insights into the impact of diet on overall well-being.

Source: www.sciencefocus.com