I
When the COVID-19 pandemic hit in 2020, it forced Krista Castro and Bryan Shin to rethink their lives. The couple, an animation director and programmer, had been working for major studios but wanted to create their own games. They decided to quit their jobs in 2021 and form A cozy gaming companion. They also became parents around the same time.
They set a goal to create a game in two years. By 2023, they had completed Fear the Spotlight, a ’90s-style horror adventure game. Although it received positive reviews on Steam, they struggled to market it and considered moving on. Then, Blumhouse, the successful horror film production company, approached them.
Blumhouse saw potential in Fear the Spotlight and offered to help. The couple was thrilled to collaborate with them as they shared a passion for horror. Together, they worked on an expanded version of the game set to release soon.
Fear the Spotlight captures the essence of ’90s horror with its atmospheric design and slow pace. Inspired by classic horror games and movies, the game aims to appeal to all horror enthusiasts, even those not typically into gaming.
The couple’s love for horror shines through in the game, incorporating elements from various horror media. With Blumhouse’s support, they look forward to sharing their vision with a wider audience.
The rats in John Cryan's lab were withdrawn and anxious, behaving in ways that mirrored those who had been bullied at work and who feared they might encounter the bully again.
Believe it or not, the good news is that they fed some of these rodents a slurry of microbes extracted from their own feces. This may sound unpleasant, but it had a surprisingly positive effect on their behavior. “That was surprising,” says Cryan, a neurobiologist at University College Cork in Ireland. “We found that the behavioral changes that were induced by stress were normalized, and they started to behave like normal animals.”
Even more surprising, the mental changes weren't brought about by changes to gut bacteria, but by modifying another key aspect of the microbiome whose importance is only now being recognized: viruses.
After all, our bodies are full of these viruses – trillions of stowaways that do no harm to our health, but instead play a key role in nurturing a beneficial microbiome and making us healthier. Recent studies have found that the influence of this “virome” can be found throughout the body, from the blood to the brain. The hope is that tweaking it might lead to new ways of treating a variety of ailments, from inflammatory bowel disease and obesity to anxiety.
Microbiome Diversity
Over the past decade, there has been a surge in interest in the microbiome (all the tiny organisms that live on and in our bodies), but that interest has focused primarily on bacteria. Until recently, the assumptions were that…
TOny, who is in his 50s, recently did a quick calculation of how much time he’s spent watching porn in his life. “The results were horrifying,” he says. Eight years. “It’s hard to even think about. The frustration is intense.”
Tony saw his first “hardcore” movie on VHS in the 1980s, when he was 12 years old. It was in his 20s that he first got online, which turned his habit into a “full-blown addiction.” For the past 30 years, he’s managed to maintain a double life: he works in care, has friendships and relationships with men and women. But there’s one side of him he keeps completely secret.
“So far, I’ve only told three people about this: two therapists, and now you,” he says. “I’ve kept it a complete secret from everyone I’ve ever known. I’m very careful to cover my tracks, even in relationships. My lack of interest in sex with my partner might be the only thing that makes her wonder.”
Tony has tried many times to stop watching porn but has never been able to go more than a month without it. He’s tried cutting down, banned masturbation, blocked porn sites, and tried to quit completely. But “the addict’s brain is very cunning and manipulative,” he says. He also tried therapy, but found it difficult to keep up with the costs long-term.
Still, Tony is grateful for one thing: he was young before the internet. “At least I had a normal youth. Parties, shows, adventures with friends. I had a girlfriend. I had a sex life. A guy like me doesn’t have that chance now.”
All statistics on pornography use in the UK and globally have skyrocketed due to the widespread use of mobile phones: in May 2023 alone, around 13.8 million people, a third of all internet-using adults, viewed pornography online. According to Ofcom
Of these, two-thirds were male. Although pornography companies do not report (or acknowledge) statistics on underage viewers, on average, children in the UK first see pornography at age 12. In a recent study, the Children’s Commissioner for England said: Much of what young people see is violent and extreme.
'TThe part where the mother and child get separated on the Red Mountain is a level fairly early in the game where you have to go back and find the mother. I was completing the sound design and music in the hospital. She was right next to my mother as she slept while she was recovering from open heart surgery. ”
Todd Baker pauses for a moment. He recalls the development process for Monument Valley 2, a 2017 indie puzzle game. Biggest success stories It will remain in the history of mobile games. The second game is more experimental than the first. The number of stories has increased and the atmosphere has changed. While the first title was all optical illusions and impossible objects, the sequel moves away from his MC Escher-inspired towers and spiers to non-Euclidean geometry and brutalism.
At the center of it all are a mother and daughter, wordlessly walking back and forth in each other's paths, desperately trying to stay together as the world heaves and undulates and does its best to tear them apart. It's about women's heritage and relationships, and for Todd there were parallels between fiction and reality. “The fact that this game is about a mother and a child, and the fact that I lost my mother at the end of the year when I was making this game, is very heartbreaking.”
“I wanted the music to speak and tell the story”…Monument Valley 2. Photo: ustwo
Monument Valley 2's soundtrack is the kind of music you want to listen to when you're not playing. Even when separated from the parent game, it's still very enveloping, very rich and textured, and provides a comfortable background for whatever you're doing. Waves of warm, organic tones and ambient, soothing sounds wash over you. This was always Baker's intention. Even before the unfortunate coincidence of fictional and real losses, Monument Valley 2's soundtrack was designed to be soothing, familiar, and gorgeous.
“Basically, what I was trying to do was create the sound of a really warm hug,” Baker said with a laugh, referring to one of the early stages of the game, when the child first comes to his mother. He described the moment he was held in his mother's arms. “At that moment, the kid comes in and I hug him, and there’s a lot of bass going on…I needed a really warm, fuzzy feeling, like this is where I want to be right now. .”
This moment in the game is very important. It's all about setting what's at stake. Yes, this story is abstract and minimalistic, but this moment has such power. Baker creates an impromptu acoustic guitar melody that he layered on three tracks and played on an EBow for a slightly supernatural sound, all backed up by an intoxicating supporting bass note, but it's not unlike the visuals here. I am doing a very important job. Establish everything that's at risk, Apple/iOS friendly, “bright on white”. If you don't watch the game to the end, you'll never see these two reunite.
That resonated with the audience, Baker said. “What's amazing is that now I get messages from people saying, 'This was the soundtrack of my childhood,'” Baker laughs. “They talked to me as adults now who were playing this game when they were 11 or 12 years old and said this is nostalgic and it's a safe space for them. It touches people's hearts. , they have a lot of nostalgia for it now.”
'It touched people's hearts'…Todd Baker performs music from Monument Valley 2 at London's V&A. Photo: ustwo
Baker was responsible for not only the music for Monument Valley 2, but also the entire sound design. Things like how a chime sounds when you swipe or tap on certain interactive elements, or how a little music plays as you explore a curious geometric world. It gets sucked in. This was an opportunity for him to emulate the approach Martin Stig Andersen took with Limbo and Inside. Both games had a huge influence on Monument Valley 2's audio, even though they couldn't be more different in tone.
“From the beginning, I was confident that I could do this. We were able to do the whole project holistically, including discussions about whether to license the music or use other artists for the trailer.” But for this one…I had to bring it myself. I wanted the music to speak and tell the story, and I wanted the rest of the development team to be really excited about it.”
As Baker says this, he imitates a hug and brings it around himself, recreating the hug he tried to evoke in the hearts and ears of players in the game's early moments. A decade after the original game was released, Apple still promotes both Monument Valley and the sequel on the App Store, with the latter installed on at least 30 million of his devices. There's no doubt that millions of people heard echoes of that hug and Baker's relationship with his mother. If you've never played this game with the sound on, find your headphones, head over to the App Store, and give it a try. I promise you, it's worth the effort.
A total solar eclipse is a great opportunity to learn about the sun
ESA/Royal Observatory of Belgium
A total solar eclipse occurs somewhere on Earth approximately every 18 months, and that has been the case throughout human history. Not surprisingly, people have been studying these dramatic events for just as long, with the first records of solar eclipses dating back more than 3,000 years. During that time, we learned an amazing amount about the Sun, Earth, and even the basic laws of physics from total solar eclipses.
For most of history, humans could only see the faint outermost layers of the sun during total days (periods when the moon covers the entire sun’s disc). This faint blanket of plasma, called the corona, has been central to the scientific advances resulting from the study of solar eclipses.
Solar eclipse in 2024
On April 8th, a total solar eclipse will pass over Mexico, the United States, and Canada. Our special series covers everything you need to know, from how and when to see a solar eclipse to the strangest solar eclipse experience of all time.
The corona is home to many of the sun’s most fascinating phenomena, including coronal mass ejections (CMEs), which occur when the sun’s swirling magnetic fields blast bundles or clumps of matter into space. If a CME were to hit Earth, it could damage satellites and power grids, and could be extremely dangerous to astronauts in space, beyond the protection of Earth’s atmosphere.
“The Sun’s magnetic activity changes over time and changes across the star’s surface.” meredith mcgregor at Johns Hopkins University in Maryland. Currently, there is no good way to predict this activity. But by studying the coronavirus, we may be able to start doing just that.
A total solar eclipse isn’t the only way to see the outermost layer of the sun. There is also a device called a coronagraph, which uses a shade to block the sun’s disk in a type of artificial solar eclipse. These instruments are used not only to study our own star, but also to study other stars that are more distant and look for planets around them that would otherwise be hidden in the glare of starlight. It is also important. “The idea of using coronagraphs to block out the light of other stars and look for extrasolar planets comes from natural solar eclipses,” MacGregor says.
The same dimness that makes the corona difficult to observe in totality also makes it an excellent target for spectroscopy. Spectroscopy works by splitting light into its constituent wavelengths. This allows researchers to determine which elements are present in a material by the unique pattern of wavelengths each element emits or absorbs. Helium was discovered using spectroscopy during a solar eclipse in 1868. This was the first time an element had been discovered by studying the sky.
Shortly thereafter, astronomers discovered what appeared to be another new element in the corona, which they named corona, but it turned out that it was simply iron heated to extraordinary temperatures of several million degrees. found. Even though it was not a new element, it was a puzzling discovery. The surface of the sun is only about 5,600 degrees Celsius, so why is the outermost layer so hot?
I said, “Imagine you’re at a campfire and you start walking away from the campfire. It’s supposed to be cold, but it’s much hotter.” Frederick Bartley at the Ohio State Science and Industry Center. “That’s what’s happening with coronavirus, but no one knows why.”
The eclipse also provided some of the first proofs of Albert Einstein’s theory of general relativity, which governs the behavior of large-scale gravity. One of the key predictions of general relativity is that massive objects should bend the trajectory of light as they pass by. Einstein first published the theory in his 1915, and evidence of its truth came in his 1919 when astronomer Arthur Eddington observed starlight bending around the sun during a solar eclipse.
As a total solar eclipse passes over Central and North America this month, astronomers will continue a long-standing tradition of using the totality to observe the sun and precisely how it affects the space around it. It turns out. The sun still has many secrets to unravel, and eclipses are one of the best times to study them.
It has been 100 days since the war in Gaza began, and it has become increasingly difficult to read the news. Her husband told me it might be time to talk to a therapist. Instead, on a cold winter morning, after fighting back tears as I read another tale of human tragedy, I turned to artificial intelligence.
“I’m pretty depressed about the state of the world,” I typed into ChatGPT. “It’s natural to feel overwhelmed,” the magazine responded, offering a list of practical advice, including limiting media exposure, focusing on the positive and practicing self-care.
I closed the chat. I was sure that I would benefit from doing all this, but at that moment I didn’t feel much better.
It may seem strange that an AI would even try to provide this kind of assistance. But millions of people have already turned to his ChatGPT, a professional therapy chatbot that provides convenient and inexpensive mental health support. Even doctors are said to be using AI to create more empathetic notes for patients.
Some experts say this is a boon. After all, AI may be able to express empathy more openly and tirelessly than humans, unhindered by shame or burnout. “We admire empathetic AI” by a group of psychological researchers I wrote recently.
But others are not so sure. Many people question the idea that AI can be empathetic and worry about the consequences if people seek emotional support from machines that can only pretend to care. Some even wonder if the rise of so-called empathic AI might change the way we think…
WWho is behind the most notorious ‘deepfake’ apps on the internet? The Guardian’s new podcast series ‘Black Box’ has been trying to answer that question for months now, as we explore a hall of mirrors. It was like wandering.
The app, ClothOff, has hundreds of thousands of followers and has already been used to generate dozens of images of underage girls in at least two cases. The photos have traumatized the girls, outraged their parents and left police at a loss as to how to stop it.
Producers Josh Kelly, Alex Atack and I followed Cross-Off’s footsteps to a nondescript, seemingly vacant address in central London. We’ve encountered fake businesses, distorted voices, and fake employee photos.
This was a frightening insight into the future we’re all heading into in our careers. In the age of artificial intelligence, is everything you see and hear on your screen real?
The search for ClothOff is just one story to tell about the times we live in. We’re in the first few years of AI infiltrating our lives, but it’s not yet deep enough that we can’t remember what life used to be.
We wanted to take a snapshot of this moment in time to explore the impact AI is already having on the world and look for clues about what’s to come. We met the scientists who pioneered AI software until they dramatically turned against it last year. We’ve heard stories of people reminiscing about their first dates with their boyfriends (smartphone chatbots), and stories of heartbreaks when the same lover turned cold due to system girlfriend updates. Ta.
We’ve been hearing about the prospect of AI systems that can detect cancer years before doctors and machines could offer desperate people what no one else has: humanity.
Everywhere we go, we encounter an even bigger mystery: people using AI. What has fascinated us again and again is the way in which we are already reshaping what it means to be human in a series about artificial intelligence that is not just about technology, but actually about us.
michael safi Presenters, today’s highlights
This week’s picks
Ash Sarkar, one of the hosts of If I Speak. Photo: Antonio Olmos/Observer
Hear Me Out Wide range of weekly episodes available Get to know some of the dramatic talents of multiple stars in this chatty theater podcast from actor Lucy Eaton. They each choose their favorite speech and act it out in a private chat, giving it a Desert Island Disc feel for the stage. In the first episode of the new series, hear Mark Gatiss perform Hamlet’s “Longing” and “Rage” “Speech the Speech” soliloquy from Jack Thorne’s Motives and Clues. Alexi Duggins
dead river Wide range of weekly episodes available This alarming story focuses on one of the most devastating environmental catastrophes in history: the 2015 Mariana Dam disaster in Brazil. The disaster led to the largest class action lawsuit in British history involving 700,000 claimants. It’s an emotional and worrying listen, packed with music that tugs at your heartstrings as you hear locals talk about their fears that the dam is sick. advertisement
The Blame of Fame: Milli Vanilli Wide range of weekly episodes available You may already know the story of Rob Pilatus and Fab Morvern, but Insecure’s Amanda Seales brings you the inside story in this fun podcast. When German producer Frank Farian asks the tight-trousered pop duo to make a deal with the devil, they are exposed as impostors, leading to exploitation and tragedy. Hannah Verdier
Time Capsule: Silver Chain Wide range of weekly episodes available The 1970s swing scene is the stuff of myth and legend, so when Paul Ditty heard that the secret club Silver Chain had kept a stash of newsletters in a safe deposit box, he couldn’t resist investigating. His brilliant unraveling of the mysterious Minnesota club begins with a simple question. How did they find the time to swap partners? HV
if i speak Wide range of weekly episodes available Novara Media journalists Ash Sarkar (above) and Moya Lothian-McLean have questions on their minds, including “Can I really be friends with my boss?” and “Are dating apps dead?” By grappling with questions, he swaps politics with personal (of sorts) issues. “Should I give my mom some money?” As Sarkar says, this is “the place where we can reveal our most free and nosy selves without judgment.” Holly Richardson
There’s a podcast for that
Comedian Paul Sinha hosts new podcast Pub Quiz. Photo: Martin Godwin/The Guardian
this week, robin winter choose the best five Comedy podcasts that actually teach you somethingfrom comedy quizzes with Chase star Paul Sinha to investigating urban legends in black culture.
Do Go On It’s surprising how little-known this Australian podcast is despite its longevity. Hosted by incredibly likeable Melbourne comedians Matt Stewart, Jess Perkins and Dave Warneke, each week one of them chooses a topic to report on. Recent episodes include History of Monopoly, Pirate Queen of Ireland, Eurovision, and more. Unlike many other long-running podcasts (Do Go On is entering its ninth year), the inside jokes are easy to follow and there’s a genuine, contagious enthusiasm from the trio.Rare podcasts that will make you laugh out loud and Full of fascinating stories.
Paul Sinha’s Perfect Pub Quiz The Chase’s Paul Sinha is also a popular touring comedian and combines these pursuits in this clever BBC Radio 4 podcast. If you can imagine him doing his set of tight 20-minute stand-up encyclopedias, you’ll be able to get pretty close to this vibrant show. In series two, Sinha takes his trivia skills to different parts of the country, testing Ipswich residents on their most famous politicians and Manchester’s tallest buildings. However, there is not much time to think, so the listener needs to respond quickly.
mom taught me Comedians Langston Carman and David Goboly explore black conspiracy theories, superstitions, urban legends, and, in their words, “the old lady’s story that your uncle told you about who wore jeans to the beach.” Dive deep into the world of “public pool. They often have hilarious guests to discuss reader suggestions. After almost 300 episodes, there’s no sign of running out of material.
big flop With only a handful of episodes to date, The Big Flop explores everything from the laughably bad movie Cats to the banned Four Loko, an alcoholic energy drink invented by a bunch of frazzled boys. It’s a show that focuses on events that didn’t go well. Hosted by actor, singer, and TikTok star Misha Brown, it was produced by pod giant Wonderly. Two weekly guests (mostly American stand-ups and performers) bring freshness to each episode, and thanks to an experienced behind-the-scenes team, it’s well-researched and well-produced.
That’s not true fish If you love comedy podcasts, you’ll be spoiled for choice with No Such Thing As a Fish, created by the writers of the long-running BBC quiz show QI. The authors started the podcast in 2014 after discovering interesting facts that weren’t aired during their research. Now his 500-episode podcast is the granddaddy of the genre, unapologetically nerdy but beautifully accessible even for non-Oxbridge fans. Winner of many well-deserved awards and published as a book, No Such Thing As a Fish is a must-listen for anyone looking for quirky facts to share at the pub table.
Why not try it…
In an 8-part series show on the streetcelebrities are taken out of the studio and presenter and veteran podcaster Alex Lugui takes the driver’s seat as they embark on a personal road trip through the places that shaped them.
just jack and will is the ultimate Will & Grace rewatch podcast with Sean Hayes and Eric McCormack.
Who is a good person? So who is the bad guy? alphabet boys Revealing secret investigations by the FBI, DEA, ATF, and other three-letter agencies in the United States.
Researchers at St. Jude Children’s Research Hospital have uncovered the structure of VMAT2, a crucial neurotransmitter transporter, shedding light on its interaction with drugs used to treat conditions like Tourette syndrome. This pioneering study offers insights into neurotransmitter transport and advances the field of neuropharmacology.
Neurons communicate through neurotransmitters, and experts at St. Jude Children’s Research Hospital have utilized their knowledge in structural biology to reveal the structure of vesicular monoamine transporter 2 (VMAT2), an essential component of neurotransmission.
By visualizing VMAT2 in different states, researchers can now better comprehend its function and how its different conformations impact drug binding. This knowledge is crucial for the development of drugs to treat hyperactivity disorders such as Tourette syndrome.
This work was recently published in the journal Nature. Monoamines, including dopamine, serotonin, and adrenaline, play a central role in neurotransmission by influencing various brain functions. Before they can be released, these molecules must be packaged into vesicles, which are compartments in cells that store neurotransmitters.
VMAT2 is a protein that moves monoamines into these vesicles, acting like a loading crane on a cargo ship. The study, led by researchers such as Dr. Chia-Hsueh Lee, Dr. Shabareesh Pidathala, and Dr. Yaxin Dai, utilized cryo-electron microscopy to analyze the structure of VMAT2 and its interactions with serotonin and drugs used to treat certain conditions.
The study revealed that different drugs bind to specific conformations of VMAT2, providing detailed insights that can aid in developing treatments for various disorders. The research also identified amino acids that facilitate neurotransmitter transport, laying the groundwork for future studies to fully understand the mechanisms involved.
The study was supported by grants from organizations such as the National Institutes of Health and the National Natural Science Foundation of China.
A new study investigated the relationship between shift work patterns, sociodemographic factors, and sleep disorders. They found that shift work, especially night shifts, significantly disrupted sleep, with about a third of all participants reporting at least one sleep disorder. The study also found that demographic factors such as gender, age, and education level influence sleep health.
A new study shows that working night shifts increases the incidence of sleep disorders, especially in young people with low levels of education.
Sleep is important not only for physical and mental health, but also for daytime and neurocognitive function. When people work in shifts (21% of workers in the European Union worked shifts in 2015), their circadian sleep-wake rhythms are often disrupted. Now, Dutch researchers have investigated the relationship between different shift work patterns, sociodemographic factors, and sleep disorders.
“Compared to working regular shifts during the day, working other shift types has been shown to have a higher incidence of sleep disturbances, especially those working rotational or regular night shifts,” GGZ Drenthe said Dr. Marike Lancel, a state mental health researcher.Institute and lead author of the study published in frontiers of psychiatry. “Notably, 51% of those working night shifts tested positive for at least one sleep disorder.”
ask about sleep
“There is a lot of evidence that shift work reduces sleep quality. However, there is little evidence of the impact that different types of shifts have on the prevalence of different sleep disorders and how this varies depending on demographic characteristics. “We know very little about whether they will,” Lancel continued.
To fill these gaps, researchers recruited more than 37,000 participants and provided demographic information indicating their shift work patterns (regular morning, evening, night, or switching between shifts).
They also completed a questionnaire screening on six common sleep disorder categories: insomnia, hypersomnia, parasomnias, sleep-related breathing disorders, sleep-related movement disorders, and circadian rhythm sleep-wake disorders.
Responses suggested that regular night shifts are the most debilitating condition when it comes to sleep. Half of night shift workers reported sleeping less than 6 hours in a 24-hour period, 51% reported one sleep disorder, and 26% reported two or more sleep disorders.
In the overall study population, approximately one-third tested positive for at least one sleep disorder and 12.6% tested positive for two or more sleep disorders.
Demographic factors and sleep health
Researchers also investigated whether demographic factors such as gender, age, and highest level of education influenced sleep health. We also considered whether participants lived alone, with a partner or children, or with others, such as friends or parents.
The results showed that although men slept less than women, sleep problems were more common in women. Age also affected sleep health. Although older participants tended to sleep less, most sleep disorders and their comorbidities were found to be more prevalent in the youngest participant group, those under 30 years of age.
Researchers found a correlation between education level and the likelihood of having disrupted sleep. “The effects of shift work on sleep are most pronounced among young people with low levels of education,” Lancel said. This group had shorter sleep duration and significantly higher prevalence of sleep disorders and their comorbidities.
Night shifts and sleep challenges
Researchers found that some people who work night shifts may have fewer sleep-related problems than others, but for the average night shift worker, this irregular work pattern can lead to less regular sleep-related problems. They said they would be more likely to struggle with healthy sleep. sleep. “People who work night shifts are unlikely to be completely immune to all the negative effects of night shifts, as they remain focused on their day jobs and out of sync with the environment in which they live,” Lancell said. explained.
The researchers also noted that their study had certain limitations. For example, people with sleep disorders may be more likely to participate in studies focused on sleep than people who sleep well. Nevertheless, the authors said their findings may provide important information for employers in occupations where shift work is common. It may also be used to educate strategies on how to best address and reduce the effects of night work and sleep days.
References: “Shift work is associated with widespread sleep disturbances, especially when working at night,” GJ Boersma, T. Mijnster, P. Vantyghem, GA Kerkhof, Marike Lancel, October 17, 2023. frontiers of psychiatry. DOI: 10.3389/fpsyt.2023.1233640
This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.
Strictly Necessary Cookies
Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings.
