Approximately 2% of the world’s fish species, or about 500 species, are known to change sex at some point during their adult life.
Some species, like the black-spotted fish (as shown above), switch from female to male periodically. Others, such as clownfish, can change from male to female, while species like coral-dwelling gobies switch genders based on environmental conditions.
This phenomenon is distinct in fish because, unlike mammals and birds, many fish species do not have their sex determined by sex chromosomes.
Environmental cues trigger changes in gene activity, influencing the production of essential hormones and enzymes. A key enzyme, aromatase, plays a critical role by converting male hormones into female ones and changing gonads into ovaries.
Social dynamics can also act as environmental signals. Clark clownfish, for instance, live among sea anemones in small groups during the breeding season. If a breeding female passes away, the largest subordinate male is known to change sex and assume her role.
Changes in water quality can signal a shift in gender as well.
Research indicates that pollutants entering rivers can induce male fish to exhibit female traits, such as spawning behaviors.
Furthermore, a 2008 study found that a mere 1 to 2 degrees Celsius increase in water temperature could skew the sex ratio of certain fish towards a higher male count.
Some sex changes are advantageous; for example, clownfish evolve to switch genders as a survival strategy to enhance reproduction. However, human activities are disrupting natural sex change processes.
Polluting rivers or warming oceans presents severe risks to future aquatic species.
This article addresses the question posed by Alex Jackson via email: “How can animals switch gender?”
For inquiries, feel free to email us at:questions@sciencefocus.com or connect with usFacebook,Twitter, orInstagramand include your name and location.
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Asteroids are an intrinsic aspect of our solar system. Millions of rocky bodies orbit the sun, including those categorized as near-Earth asteroids, which occasionally come close to our planet. While cinematic portrayals often depict asteroid strikes as abrupt, inevitable catastrophes, experts contend that in reality, the risk is significantly more manageable and frequently preventable.
But what are the actual probabilities of an asteroid colliding with Earth? Recent studies shed light on this issue and offer some unexpected insights.
What are the chances that an asteroid will hit Earth?
A major asteroid impact would have effects that could be felt globally. Depending on its landing site, it might either harmlessly drop into the ocean or inflict severe damage on populated regions.
“Most people on Earth are likely aware of moderate to large asteroid impacts,” explains Carrie Nugent, a planetary scientist at the Olin Institute of Technology in Massachusetts.
However, Nugent emphasizes that catastrophic outcomes are exceedingly rare. While our planet has faced significant asteroid impacts throughout its history, including a notable one that contributed to the extinction of the dinosaurs 66 million years ago, current scientific understanding suggests there is no immediate cause for alarm.
New research on asteroid impact probability
Nugent, along with a team from Aalborg University in Denmark, employed computer simulations to analyze the risks associated with asteroid impacts. Their research concentrated on asteroids akin to recognized Near Earth Objects (NEOs).
Utilizing the publicly available NASA JPL Horizons system, they simulated the orbits of these asteroids to determine the frequency with which they intersect Earth’s orbit, allowing researchers to estimate the likelihood of large asteroids striking our planet.
According to their findings published on August 12th in the Planetary Science Journal:
Asteroids over 140 meters (460 feet) – Roughly equivalent to the length of a small cruise ship
Collisions with Earth approximately once every 11,000 years
Keeping asteroid risks in perspective
Understanding probabilities like “once every 11,000 years” can be complex. To provide clarity, Nugent compared asteroid impacts to other more familiar real-world events.
Her analysis revealed that:
You are more likely to survive an asteroid impact than to be struck by lightning.
Conversely, your chances of dying in a car accident are significantly higher than from an asteroid collision.
There are also other low-probability but high-risk events, such as the collapse of a deep hole in dry sand, that can result in fatalities but remain largely unknown to the general public.
“This is an extremely rare cause of death that many are unaware of,” Nugent noted, underscoring how human perception often miscalculates risk.
Can asteroid collisions be prevented?
In contrast to popular narratives in films and literature, asteroid strikes are not fate-driven events. In fact, scientists have demonstrated that altering an asteroid’s trajectory is possible.
In 2022, NASA’s DART mission successfully changed the path of a small asteroid that posed no threat to Earth. This experiment showcased that, with sufficient warning, we could potentially deflect a hazardous asteroid and avert a collision entirely.
“This is the only natural disaster we can completely prevent,” Nugent asserts.
Why asteroid tracking is important
Continuous research and sky survey initiatives are crucial for planetary defense. Early detection and tracking of near-Earth asteroids provide scientists ample time to evaluate risks and take necessary actions if needed.
Modern asteroid detection systems are continually improving, diminishing uncertainty and enhancing Earth’s preparedness against cosmic threats.
Conclusion
Though asteroid strikes captivate public imagination, scientific evidence indicates that they are infrequent, quantifiable, and preventable. Advances in tracking technology and the success of missions like NASA’s DART test reassure us that Earth is better shielded than ever.
Experts suggest that asteroid research should foster confidence and continued investment in planetary defense rather than fear.
Warm waters from the Atlantic near Greenland are now heating the deep layers of the Arctic Ocean, an area once considered relatively insulated from climate change.
The Arctic Ocean has seen a reduction of about 40% in its sea ice cover over the past 40 years, primarily due to the impact of atmospheric warming on sea levels. Researchers at the Ocean University of China evaluated the latest data collected by icebreakers to assess the temperature increase of the ocean floor.
In the Eurasian Basin, which is one of the ocean’s two principal sections, temperatures at depths ranging from 1500 meters to 2600 meters have increased by 0.074 degrees Celsius since 1990.
While this temperature rise may seem minor, it equates to nearly 500 trillion megajoules of energy. Such energy could potentially melt up to one-third of the least extensive sea ice area.
“The deep ocean is more dynamic than previously assumed,” states Chen Xianyao, one of the research team members. “We suspected that the deep ocean was warming, but not at this pace.”
An underwater ridge separating Greenland and Siberia divides the Arctic Ocean into two basins. The Amerasian Basin is primarily cut off from the Pacific Ocean by the shallow Bering Strait. However, warm Atlantic waters can still flow north along the Scandinavian coast into the upper Eurasian Basin through an extension of the Atlantic Meridional Overturning Circulation (AMOC). During winter, when seawater freezes, the salts are released, resulting in denser water that sinks and drags some warmer Atlantic water down with it.
Geothermal heat from the Earth warms the deep waters of the Eurasian Basin.
Previously, these warming trends were balanced by cold water flowing down from a neighboring basin east of Greenland. Yet, as the Greenland ice sheet continues to melt, more freshwater is entering the Greenland Basin. This influx has slowed the downward movement of cold, salty water, raising the temperature of deep waters in the Greenland Basin from -1.1°C to -0.7°C—a significantly rapid increase. Consequently, the influx of cold Greenland waters is no longer counteracting the heat from geothermal sources or the warm Atlantic waters sinking into the Arctic.
“The rising temperatures in the Greenland Basin are now reaching the Arctic,” says Son Louise, another research team member.
This research uncovers new warming mechanisms deep within the Arctic Ocean, “indicating a broader trend of global warming,” according to James McWilliams from UCLA.
The ongoing warming might eventually contribute to the melting of both sea ice and permafrost found on the ocean floor, which contains ice-like structures known as clathrates. If disturbed, these can release methane into the atmosphere, a phenomenon believed to have contributed to the Permian mass extinction.
Astronomers have a limited timeframe to determine if they will intervene to stop asteroid 2024 YR4 from colliding with the moon in 2032. A brief observation period utilizing the James Webb Space Telescope is set to commence in February, as new findings indicate that the potential for impact is rising to over 30%, posing a significant threat to satellites and future lunar infrastructures.
Discovered late last year, 2024 YR4 quickly emerged as the most probable asteroid to strike Earth. The worst-case scenario initially estimated a collision probability of 1 in 32 for 2032. However, further observations have nearly eliminated the chance of an Earth impact, leaving a 4 percent possibility of a collision with the moon, which could endanger numerous vital satellites orbiting Earth due to debris.
Despite the considerable risk associated with this asteroid, space agencies have yet to take action, although NASA researchers are exploring potential deflection strategies, such as deploying a nuclear charge near the asteroid.
The asteroid has recently moved out of range for Earth’s telescopes, limiting astronomers’ ability to obtain further data on its orbit until it reappears in 2028, which may not allow enough time to execute a deflection mission.
Fortunately, the James Webb Space Telescope (JWST) anticipates a brief operational window to observe the asteroid in February 2026 and again in April 2024, offering a critical opportunity to plan a deflection mission. Andrew Rivkin from Johns Hopkins University in Maryland remarked, “By 2028, it will be in close proximity, so capturing data in early 2026 grants us additional time.”
This advantageous positioning will enable JWST to observe 2024 YR4, which follows a distinct orbit around Earth, undetectable by other ground-based telescopes, but the observation will still be challenging, as the asteroid is expected to be dim, even for JWST’s highly sensitive instruments. There will be two narrow windows for observation on February 18th and 26th.
Rivkin and his team computed how new data regarding the asteroid’s positions and velocities could alter the existing understanding based on these observations. Their findings indicate an 80% likelihood of reducing the probability of a lunar impact to under 1%, while there is a 5% chance that the risk could increase to 30% or higher. JWST should have a chance to repeat these observations in 2027, but this will provide less time for decision-making, according to Rivkin.
Nonetheless, it remains uncertain whether space agencies would opt to plan missions in the event of increased risks. “The question of whether planetary defense extends to the moon is entirely new, and different agencies may have varied responses,” Rivkin noted. “If a company operates many satellites, they might advocate for a particular course of action.”
Richard Moisle from the European Space Agency indicated that while the current budget does not allocate for deflection or reconnaissance missions regarding the asteroid, they will reevaluate if next year’s observations indicate a heightened risk of collision. “We chose to delay our decision until next year to allow for a thorough evaluation of our options,” Moisle stated.
Climate change is already impacting our lives negatively
Ahmad al-Rubaye/AFP via Getty Images
When considering the dangers posed by climate change, floods and violent storms might come to mind, or even unprecedented heat waves. A study conducted in the latter half of 2024 revealed that most Americans view extreme weather as the chief climate threat. Yet, climate change disrupts daily life in many other persistent ways.
“These events significantly impact people’s lives but often don’t make headlines,” states Jennifer Carman from Yale University.
These more subtle consequences of climate change may seem trivial compared to disasters, like worse allergies or increased commute times, but they collectively signify major shifts, according to Carman. Understanding these issues is crucial for individuals to brace for climate changes affecting their everyday experiences. Remarkably, around half of Americans report feeling the effects of climate change a decade ago—double the number of those who don’t.
“Not everyone is affected by severe events,” Carman remarks. “However, everyone experiences the impacts of daily life consistently.”
Climate change drives up food prices and more
Elevated temperatures associated with climate change inflate prices. In a study by Fridrikik and her team at the European Central Bank, they identified strong correlations between temperature and numerous global price indices. They discovered that higher average temperatures lead to both inflation and extreme weather, particularly in equatorial regions, with impacts persisting year-round.
They projected that by 2035, this would escalate annual price inflation rates by 0.5% to 1.2% for various goods, depending on global greenhouse gas emissions. Agriculture is notably susceptible to weather variations, meaning its price impacts may be about twice as significant. “This unpredictability complicates food production,” Carman notes.
Air conditioning usage is rising and becoming more costly
Increasing temperatures escalate air conditioning expenses. In hotter regions, users will need to operate their air conditioners longer and more frequently. This demand can exceed affordable energy bills.
Individuals in previously temperate areas, such as London or the US’s Pacific Northwest, find themselves needing to install air conditioning for the first time. Globally, soaring cooling expenses negate any reductions in heating costs.
Hot weather disrupts sleep
Even with air conditioning, high nighttime temperatures can hinder sleep quality. Research by Renjie Chen from the University of Hudan, along with colleagues, assessed over 20 million nights of sleep data from hundreds of thousands in China. They found that a 10°C rise in night temperature could raise the likelihood of insufficient sleep by 20%. Under severe emissions scenarios, they estimate that each individual in China might lose about 33 hours of sleep per year by the century’s end.
This isn’t just a localized issue. Research by Kelton Minor from Columbia University showed that elevated nighttime temperatures correlated with reduced sleep across tens of thousands of individuals in 68 countries. Findings suggest higher nighttime temperatures result in decreased sleep—mainly affecting older adults and women in hotter, poorer regions.
Climate change intensifies air pollution
Air pollution poses serious health risks, whether from PM2.5 particles or ozone. Recent research indicates that combining higher temperatures with existing pollutants can exacerbate the harmful effects of air quality, particularly among those who spend extended time outdoors.
Historically, fossil fuel-driven pollution has decreased as power grids have become cleaner, yielding public health benefits. However, as climate change fuels more frequent and severe wildfires, decades of progress may be undone, exposing communities to wildfire smoke. One study forecasts that increased smoke exposure could lead to around 700,000 additional deaths in the U.S. by 2050.
Supporting evidence aligns with anecdotal perceptions; William Andreg from the University of Utah and his team found that the pollen season in North America has lengthened since the 1990s, with overall pollen levels increasing by 21%. The majority of these changes have been attributed to human-induced warming.
Travel delays accumulate, whether long-haul or daily
Climate change is increasingly responsible for weather-related interruptions in transportation systems, leading to billions of wasted hours.
For instance, Valerie Mueller and colleagues from Arizona State University studied the impact of routine coastal flooding on commute times in the eastern U.S. They estimated individuals experience about 23 minutes of delays annually due to these floods, which is double the time recorded 20 years ago. Their analysis revealed these delays stem mainly from rising sea levels rather than extreme storm surges.
While a handful of extra minutes might seem negligible, it accumulates to billions of lost hours overall. Over the coming decades, further sea level rise could escalate delays to hundreds of minutes per person annually.
Weather-induced delays are also increasing in train services and airports. The International Air Transport Association reported that weather-related delays rose from 11% of total delays in 2012 to 30% in 2023. Additionally, even if passengers board their flights, climate change can exacerbate certain turbulence, contributing to rougher flights.
On Friday, the White House unveiled a budget proposal outlining significant reforms at NASA as part of its initiative to secure $163 billion in federal funding.
The suggested reductions include a nearly 25% cut, translating to over $6 billion, from NASA’s budget. The most substantial decreases target the agency’s Space Science, Earth Science, and Mission Support divisions.
The blueprint also advocates for a space launch system rocket and Orion spacecraft aimed at returning astronauts to the moon, but proposes to terminate the program after just two more missions.
The SLS Megarocket and Orion Spacecraft were fundamental components of NASA’s Artemis Moon initiative, named after the Greek goddess associated with the moon. This mission aimed to create a base camp on the lunar surface and facilitate regular missions.
Critics have pointed out that the SLS rocket exceeds the scale and capabilities of the historic Saturn V booster used in the Apollo missions, resulting in significant delays and budget overruns.
President Donald Trump’s budget draft seeks to terminate the Artemis II test flight, expected to launch in early 2026, as well as the Artemis III mission, planned for mid-2027.
A document outlining the budget requests indicates a shift in NASA’s funding priorities aimed at “returning to the moon and placing the first human on Mars.”
The proposal envisions a hub for space stations in lunar orbit, along with the cancellation of the lunar gateway project, which was intended to play a crucial role in upcoming deep-space missions.
Other significant changes include a $2.265 billion reduction in NASA’s Space Science budget, a $1.161 billion cut in Earth Science funding, and a $5 billion decrease for the International Space Station.
Additionally, these budget cuts will shrink the size of the crew aboard the space station and limit scientific research capabilities, while preparing for its decommissioning by 2030, as part of a transition to commercial space stations, dependent on budget requirements.
In an internal email obtained by NBC News, NASA’s acting administrator, Janet Petro, stated that the proposed budget “demonstrates the administration’s backing for our mission and sets the foundation for our next significant accomplishment.”
She encouraged NASA employees to “exercise patience, resilience, and the discipline needed to achieve unprecedented feats,” acknowledging the budgetary constraints as “difficult choices” that would result in some activities being discontinued.
Among other points, Petro highlighted that under the discretionary budget, NASA would dissolve the SLS rocket and Orion spacecraft programs, as well as the gateway initiative, and halt funding for the Mars sample return project.
Petro’s communications did not specify which aerospace and defense contractors might gain or lose federal support due to these proposed changes. However, companies such as SpaceX, led by Elon Musk, Blue Origin, founded by Jeff Bezos, and the United Launch Alliance (a collaboration between Boeing and Lockheed Martin) are positioned as leading launch providers in the absence of the SLS.
We've all seen it frequently in science fiction films, so the concept seems completely plausible. Characters enter commands, and spacecraft reverse speed, jump to hyperspace, and create wormholes through space and time.
Whatever the terminology, the outcome is always the same. They fly through fictional universes faster than the speed of light, so travel between star systems is not only possible, but practical.
But in the real universe we live in, a huge barrier appears to forbid this. According to Albert Einstein's special theory of relativity, it cannot travel faster than light.
The light travels at an incredible speed of approximately 3 x 108 meters per second. This means that when you look at the universe, you won't see the heavenly objects as they are currently appearing. You can see how light from them first emerged when they departed across the universe.
Within the solar system, these delays are relatively short. For example, it takes only one second of sunlight to bounce off the surface of the moon and reach the Earth, but it takes eight minutes to cover the distance between the sun and our world.
Due to the enormous distance from us, if the sun suddenly disappears, you won't notice until 8 minutes later – Photo Credit: Getty
The more visible the longer the delay, which gives rise to the light-year concept as a measure of distance. Our closest star, Proxima Centauri, is about 4.25 light years away. In other words, it takes 4.25 years to get there from there. Therefore, the stars are not as they are now, and look like 4.25 years ago.
Beyond the vast expanse of the universe, distance is ultimately measured in billions of light years. This is what makes cosmology possible. The more we see the universe, the older the objects we see, and we can diagrammaticize today's evolution into stars and galaxies.
But if you can travel there and see what those objects look like now, wouldn't that be great?
Having a warp drive may sound like it, but it has some pretty weird results. For one thing, it would ruin the notion of causality.
Causality is our common sense perception that precedes effectiveness. But if you saw a faster spaceship trip towards you, you will see the ship in two places at once. The light carrying information about the ship's departure would not have reached the eye before the ship could be seen along the way.
Worse, the mathematics of relativity shows that if the speed exceeds the speed of light, literally time travel is possible.
This creates a full-scale causal paradox such as the famous “grandfather's paradox.” And how does it work – will you just no longer exist?
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Negative energy inside
At first glance, Einstein's theory appears to protect us from such head-envelope challenges, as it appears to make it impossible to move faster than light. Masu.
According to the equation, the energy required to accelerate the ship to such a speed is infinite. However, researchers then began to look at mathematics in more detail.
A general theory of relativity – Einstein's extension of his special relativity – he proposes that the universe is made of adaptive fabrics called the space-time continuum, and he uses gravity to make this fabric I explained that it was distorted.
Who knows if tachyons exist, but if so, the theory suggests that it travels faster than light. – Image credits: Science Photography Library
1994, Physicist Dr. Miguel Alcubière At the University of Wales, and at Cardiff, we showed that solutions exist within the theory of general relativity that can be interpreted as warp drives. The problem was that it requires an exotic substance known as “negative energy” to make it work.
Astronomers have toyed using the concept of negative energy to explain why the universe appears to be accelerating, but with an understanding of physics, matter is comfortable to exist It cannot be done.
Then in May 2024, A group of researchers reexamined mathematics We will use only the types of particles and energy that make up the planet and people to see if the Alkbiere Warp phenomenon can be generated.
Their conclusion: Yes, they did. Dr. Jared Fuchs And colleagues at the University of Alabama in Huntsville, USA, discovered that they could arrange for normal material and energy to create warp phenomena and transport people through space. But there was a catch: they could only make it work at sub-light speed.
“It takes a lot of energy to make small changes to the space,” Fuchs says. To move the passenger seat, the size of a small room requires a small house-sized “warp bubble” for the size of a small room. And to make it, you need to narrow the mass of Jupiter several times. It becomes the volume that is the size of a small asteroid.
“now, [is that] Is it possible? perhaps. [Is it] Practical? I wouldn't say that,” says Fuchs. Even if it was possible to create such a device, the old boundaries still exist. To accelerate faster than the speed of light, you need an infinite amount of energy.
“We will not resolve the future of rapid transportation like Star Trek,” admits Fuchs.
Trouble with Tachon
Other researchers have conducted their own research into relativity. Professor Andrzej Dragan Collaborators at the University of Warsaw in Poland decided to consider possible solutions within the equation of particles that travel faster than light.
Physicists have previously messed with such concepts. They even called such virtual particles “tachyons,” but essentially considered them more than mathematical curiosity. However, Dragan and her colleagues found an equation explaining Tachyon's behavior.
“Mathematically, they make perfect sense,” says Dragan. In other words, our familiar world of secondary particle particles could coexist with the upper heart family of the second family, the tachyon.
Unfortunately, this does not mean that spacecraft can speed faster than light. To do that, Dragan explains that it requires the infinite energy that Einstein predicted, as well as the infinite energy to slow the Tachyon down to a sub-blue-minal speed.
“You can't exceed the speed of light in either direction,” says Dragan.
Nevertheless, the study We have proposed some fascinating results that may explain some of the most inexplicable observations physicists are working on.
When dealing with Tachon, Dragan and his colleagues encountered the causal issues they had been expecting. But the more I looked into these details, the more I realized that something surprising was happening. The strict lack of causes and effects was very similar to the behavior of normal, everyday subatomic particles.
The theory of relativity explains the behavior of the universe at its largest scale, while quantum theory describes the subatomic domain as a very different location.
Quantum theory introduces probability into particle interactions. For example, we know that an atom can absorb photons of light and at some stage it will re-emit that photon, but we cannot predict when or in which direction it will take.
In other words, the exact cause is hidden from us, and all we have left is an observable effect. Dragan suggests that when tachyon interacts with normal substances, the outcome of that interaction is unpredictable – like the emission of photons.
So, while these latest ideas do not seem to open a route to practical warp drives, they may only show a deeper look at the nature of the cosmos and the origins of quantum behavior.
About our experts
Dr. Jared Fuchs He is the CEO of Celedon Solutions Inc. and works in the Faculty of Physics at the University of Alabama in Huntsville, USA. His work has been published Classical and quantum gravity.
Professor Andrzej Dragan He is a filmmaker and professor of physics at the University of Warsaw in Poland, and a visiting professor at the National University of Singapore. His work has been published Physical review, Classic and Quatnam Gravity and New Journal of Physics.
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In the UK, thousands of people are currently experiencing issues making or receiving calls due to a network outage affecting Three.
Downdetector, a website that tracks outages, has received over 10,000 reports of problems across mobile networks on Thursday.
Customers of smaller mobile providers like Smarty and iD Mobile are also impacted as they rely on Three’s network.
While Three is working on resolving the issue, there is no specific timeline for a fix. iD Mobile has informed customers that engineers have identified and isolated the problem.
Three has approximately 10.5 million customers in the UK, with many expressing frustration on social media due to the disruption.
Some customers have reported missing important appointments or feeling stranded due to the inability to make calls.
It is uncertain if customers will receive compensation for the disruption, with Ofcom suggesting that refunds may be appropriate.
Following approval from the Competition and Markets Authority, Three’s merger with Vodafone has been finalized in a £16.5bn deal.
In a statement on X, Three acknowledged the issue with voice services and assured customers that data and emergency calls will not be affected.
Most of us are aware that our planet is constantly spinning around its own axis as it orbits the sun. However, the Earth actually rotates around a tilted axis of 23.44°, leading to changes in its slope over time due to natural oscillations and cycles.
Human activities, such as global warming and groundwater extraction for irrigation, are causing significant changes in Earth’s tilt. Scientists have found that as polar ice melts and water redistributes, it can affect the planet’s rotation.
Researchers estimate that pumping large amounts of groundwater for irrigation purposes has led to significant changes in Earth’s tilt over recent decades. This redistribution of water mass is impacting the planet’s rotation, with measurable effects on sea levels and pole shifts.
Experts like Professor Seo Ki-won note that even small changes in water mass can affect Earth’s rotation, leading to shifts in its axis. These changes have been observed over the past few decades, indicating the impact of human activities on a global scale.
While these changes may not directly impact the climate, they do have implications for systems that rely on precise measurements and timing, such as GPS and financial markets. As Earth’s rotation slows due to mass redistribution, adjustments will need to be made to prevent system failures.
It is becoming increasingly clear that human activities are influencing not just the climate, but also the fundamental movements of Earth within space. As we continue to alter the planet’s mass distribution, we must be prepared to adapt our technologies and systems to accommodate these changes.
The human genome consists of approximately 3 billion DNA base pairs. If these base pairs were letters grouped together on a single line, they would fill more than 6,000 novels, too large to fit in a cell. Instead, some proteins organize and reform DNA into a more functional 3D structure called DNA. chromatin. These proteins regulate how different parts of the genome interact, controlling which genes are activated and which remain silent within each cell. One such protein is CCCTC binding factor or CTCF.
For CTCF to work, it must first bind to a specific spot on the DNA called CTCF. binding site. Scientists report that these CTCF binding sites behave differently in each scenario. Some lose their binding ability due to chemical interactions within the DNA, while others remain stable. Scientists call something stable Persistent CTCF binding site.
Scientists have previously reported that mutations in CTCF binding sites are common in cancer cells and disrupt the normal 3D structure of the genome. However, it was unclear whether these mutations were concentrated at persistence sites or what role they played. Australian researchers sought to understand mutations in persistent CTCF binding sites and how they affect different cancers.
To address these questions, the research team developed a computational tool based on machine learning models. CTCF-INSITE. Their tool uses genetic data and the interactions of organic compounds such as methyl in the genome to predict which CTCF binding sites are likely to persist even as CTCF protein levels decline. Researchers will use this tool to determine which persistent CTCF binding sites across the genome may be particularly vulnerable to mutations and whether these mutations are associated with cancer growth. I mapped it.
Using data from several human cell culture samples, including prostate cancer cells, breast cancer cells, and lung cancer cells, researchers developed a tool that allows them to distinguish between stable and unstable CTCF binding sites. trained. They exploited characteristics such as protein binding strength, the relative location of binding sites within the genome, and how distant regions of DNA interact to produce proteins.
The researchers then looked at mutation data from 12 types of cancer. International Cancer Genome Consortium. To avoid imbalance, we filtered out data entries with too few or too many mutations. Next, we applied CTCF-INSITE.A tool to test whether persistent CTCF binding sites are more likely to mutate in cancer cells than other CTCF binding sites.
They found significantly more mutations in persistent CTCF binding sites in all cancer types examined. This means that there were more mutations at these sites than would be expected by random chance. The researchers noted that the mutations were specific to the CTCF binding site, rather than in parts of the DNA close to it. They also reported that these mutations were more prominent in breast and prostate cancer cells than in other types of cancer.
The researchers also sought to understand whether these mutations alter the 3D structure of the genome. Using experimental techniques such as fluorescence imaging, they examined some of these cancer-specific mutations and found that many of them alter the genome structure and reduce the strength and effectiveness of CTCF binding. It turned out that. They explained that this reduction could affect gene expression in a way that promotes cancer growth.
The researchers emphasized that their findings were not limited to one or two types of cancer, as similar results were found for stomach, lung, prostate, breast and skin cancers. Although the exact mutation patterns vary between cancers, persistent CTCF binding sites were reported to have consistently higher mutations overall.
The researchers concluded that their findings may help other cancer researchers understand similarities in the onset and progression of multiple cancer types. They also proposed that their machine learning tools could provide future researchers with CTCF binding site candidates relevant to experiments investigating undocumented causes of cancer.
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