Tag Archives: gut

New Research Reveals How Gut Microbes Influence Human Brain Evolution

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Humans have larger brains relative to body size compared to other primates, which leads to a higher glucose demand that may be supported by gut microbiota changes influencing host metabolism. In this study, we investigated this hypothesis by inoculating germ-free mice with gut bacteria from three primate species with varying brain sizes. Notably, the brain gene expression in mice receiving human and macaque gut microbes mirrored patterns found in the respective primate brains. Human gut microbes enhanced glucose production and utilization in the mouse brains, suggesting that differences in gut microbiota across species can impact brain metabolism, indicating that gut microbiota may help meet the energy needs of large primate brains.

Decasian et al. provided groundbreaking data showing that gut microbiome shapes brain function differences among primates. Image credit: DeCasien et al., doi: 10.1073/pnas.2426232122.

“Our research demonstrates that microbes influence traits critical for understanding evolution, especially regarding the evolution of the human brain,” stated Katie Amato, lead author and researcher at Northwestern University.

This study builds upon prior research revealing that introducing gut microbes from larger-brained primates into mice leads to enhanced metabolic energy within the host microbiome—a fundamental requirement for supporting the development and function of energetically costly large brains.

The researchers aimed to examine how gut microbes from primates of varying brain sizes affect host brain function. In a controlled laboratory setting, they transplanted gut bacteria from two large-brained primates (humans and squirrel monkeys) and a smaller-brained primate (macaque) into germ-free mice.

Within eight weeks, mice with gut microbes from smaller-brained primates exhibited distinct brain function compared to those with microbes from larger-brained primates.

Results indicated that mice hosting larger-brained microbes demonstrated increased expression of genes linked to energy production and synaptic plasticity, vital for the brain’s learning processes. Conversely, gene expression associated with these processes was diminished in mice hosting smaller-brained primate microbes.

“Interestingly, we compared our findings from mouse brains with actual macaque and human brain data, and, to our surprise, many of the gene expression patterns were remarkably similar,” Dr. Amato remarked.

“This means we could alter the mouse brain to resemble that of the primate from which the microbial sample was derived.”

Another notable discovery was the identification of gene expression patterns associated with ADHD, schizophrenia, bipolar disorder, and autism in mice with gut microbes from smaller-brained primates.

Although previous research has suggested correlations between conditions like autism and gut microbiome composition, definitive evidence linking microbiota to these conditions has been lacking.

“Our study further supports the idea that microbes may play a role in these disorders, emphasizing that the gut microbiome influences brain function during developmental stages,” Dr. Amato explained.

“We can speculate that exposure to ‘harmful’ microorganisms could alter human brain development, possibly leading to the onset of these disorders. Essentially, if critical human microorganisms are absent in early stages, functional brain changes may occur, increasing the risk of disorder manifestations.”

These groundbreaking findings will be published in today’s Proceedings of the National Academy of Sciences.

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Alex R. Decassian et al. 2026. Primate gut microbiota induces evolutionarily significant changes in neurodevelopment in mice. PNAS 123(2): e2426232122; doi: 10.1073/pnas.2426232122

Source: www.sci.news

Discover What a Healthy Gut Microbiome Looks Like

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The trillions of microorganisms that inhabit our intestines significantly impact our health.

Tom Leach/Science Photo Library

We frequently hear about the benefits of certain foods for your microbiome and overall health. However, the exact composition of a healthy gut microbiome has not been fully understood until now. A recent study involving over 34,000 individuals has advanced our knowledge of the microbial combinations that indicate low inflammation, robust immunity, and healthy cholesterol levels.

The gut microbiome influences various aspects of health, including the immune system, aging, and mental well-being. While many home testing kits claim to analyze gut composition, their effectiveness remains questionable, as defining a “healthy” microbial balance is complex.

Earlier efforts have mainly concentrated on species diversity, under the assumption that a greater variety of bacteria is beneficial. However, since microbiomes differ significantly between individuals, pinpointing specific microbial communities linked to particular health outcomes is challenging.

“The interplay between our diet, gut microbiome composition, and health is intricate. The only way to unravel these connections is through large sample sizes,” explains Nicola Segata from the University of Trento, Italy.

To develop a comprehensive understanding, Segata and his team analyzed data from over 34,500 participants in the PREDICT program, conducted in the UK and the US by the microbiome testing company Zoe, and cross-referenced the findings with data from 25 additional cohorts in Western nations.

Among the thousands of bacterial species in the human gut, researchers focused on 661 species present in over 20% of Zoe participants. They identified 50 bacteria closely linked to health markers, such as BMI and blood glucose levels, as well as 50 associated with poor health.

The 50 “good” bacterial species (22 of which are newly identified) seem to affect four key areas: inflammation and immune function, body fat distribution, and blood sugar regulation.

Healthy participants, with no known medical issues, carried approximately 3.6 more of these beneficial species than those with health conditions, while individuals at a healthy weight had about 5.2 more species compared to those who were obese.

Researchers propose that the gut microbiome plays a crucial role in releasing chemicals that influence health outcomes, including cholesterol transport, inflammation reduction, fat metabolism, and insulin sensitivity.

Among the species analyzed, most bacteria classified as either “good” or “bad” belong to the genus Clostridium. Within this group, 40 species from the family Lachnospiraceae were highlighted; 13 showed positive impacts while 27 were linked to negative effects.

“This research identifies a subset of bacteria worth further exploring for their potential impacts on health conditions like high blood sugar and obesity,” states Ines Moura from the University of Leeds, UK.

The connection between these microorganisms and diet is analyzed through food questionnaires and data collected via the Zoe app, which suggests aiming for at least 30 different plant types each week and consuming three servings of fermented foods daily, promoting fiber intake and reducing ultra-processed food consumption.

The findings indicate that most microorganisms tend to enhance health with a balanced diet or exacerbate health issues with a poor diet. However, 65 of the 661 microorganisms exhibited an inconsistent relationship.

“These 65 bacteria highlight the complexity of our microbiome,” remarks Segata, who also consults for Zoe. “Their effects might depend on the presence of other microorganisms, specific bacterial strains, or particular dietary factors.”

This classification of “good” and “bad” bacteria enables researchers to assess an individual’s gut health on a scale from 0 to 1000, which is already being applied in Zoe’s gut health assessments.

“Think of a healthy gut microbiome as a network of chemical factories. We need a diverse range of species and a predominance of beneficial bacteria to generate health-promoting chemicals that benefit the entire body,” says Tim Spector, PhD from King’s College London and co-founder of Zoe.

Nonetheless, establishing a definitive model of a healthy gut microbiome is challenging. “Defining a healthy microbiome is not straightforward, as gut composition is impacted by diet and can shift due to environmental factors, age, and health conditions requiring long-term treatment,” adds Moura.

“We need to view our bodies and microbiomes as two intricate systems that combine to create an even more complex system,” says Segata. “A change in one element can subtly affect everything else. Understanding the causative relationships is often quite complicated.”

Segata advocates for larger studies to further clarify these links and represent a wider global population. However, once a health and microbiome baseline is set, he believes it should be feasible to recommend specific foods to optimize gut bacteria.

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Source: www.newscientist.com

The Gut Microbiome: Influencing Our Personality Traits

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Fecal bacteria observed through an electron microscope

Science Photo Library / Alamy Stock Photo

Rats that received gut microbiomes from energetic human infants seem more inclined to explore their surroundings. This research suggests that the bacteria present in our guts during childhood may influence our personalities.

“This indicates that our microbes play an active role in emotional development, rather than merely being passive presence,” explains Harriet Scherekens from University College Cork, Ireland, who was not involved in the study.

Increasing research identifies a link between the microbial communities in our guts and various aspects of our well-being, emotions, and mood. For instance, individuals lacking certain gut bacteria types seem to face a higher risk of depression and anxiety.

While it remains uncertain whether bacteria are the cause of these emotional shifts or if the microbial communities alter in response to user actions, some evidence suggests that changes in the microbiome can influence an individual’s mood. For example, fecal transplants from depressed individuals to rats appear to induce depressive behavior. Conversely, depressed rodents receiving fecal transplants have shown improved symptoms upon preliminary examination.

To delve deeper into how the gut microbiome relates to temperament, Anna Artshinki and colleagues at the University of Turku in Finland conducted fecal transplants from infants into young rats.

Initially, the team evaluated the personalities of 27 toddlers aged 2.5 years using standard temperament assessments and an activity that encouraged play with bubble guns.

“Although we couldn’t study anxiety in 2-year-olds directly, we anticipated assessing behavioral differences, such as levels of inhibition versus sociability,” notes Artosinki.

From their evaluations, researchers classified 10 infants as energetic and 8 as inhibited and withdrawn. They then selected four energetic and four restrained infants (split evenly between genders) for fecal sample collection.

Fecal samples spiked with glycerol, alongside control samples, were transplanted into 53 22- or 23-day-old rats whose intestines had been pre-cleaned.

Artshinki’s team then subjected the rats to a variety of behavioral tests. They discovered that rats with microbiomes from energetic infants displayed a greater exploratory tendency compared to those receiving control implants or feces from inhibited infants.

To investigate how gut bacteria might influence the brain, the researchers also examined rat brain tissues for gene activity changes. This analysis indicated that rats receiving microbiomes from inhibited infants showed reduced activity in dopamine-producing neurons, a neurotransmitter linked to rewarding risk-taking behavior.

“This study effectively illustrates how the early childhood gut microbiome contributes to shaping behavioral tendencies,” Scherekens remarks. “By transferring microbiomes from children to rodents, researchers have created a valuable translation between microbes, human temperament, and brain function.”

This indicates a gut-brain pathway that impacts curiosity, reward, and motivation through the dopamine system, Scherekens adds.

Nonetheless, Artshinki cautions against overstating the implications. “Overall, adult temperament traits are strongly correlated with genetics, yet environmental factors—potentially including the microbiome—may play a role in certain behavioral distinctions.”

Artosinki emphasizes that whether microbes drive the differences in children’s behaviors remains an open question. It’s possible that children exhibiting more active traits interact with their environment and new foods in unique ways, thereby developing distinct microbiomes as a result.

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Source: www.newscientist.com

Substituting Sugar with Artificial Sweeteners Could Enhance Your Gut Microbiome

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Artificial sweeteners might support gut microbiome health

Robert K. Chin/Alamy

Using low-calorie sweeteners instead of sugar may stimulate beneficial gut bacteria and aid in weight loss maintenance. This conclusion emerges from one of the longest studies on sweeteners, suggesting these alternatives might not be as detrimental as some previous reports indicate.

Several recent analyses have cast doubt on the health benefits of various low-calorie sweeteners. Although they are widely favored by those wishing to shed pounds, research indicates they may increase hunger, elevate blood sugar, and heighten the risk of heart-related illnesses. In 2023, the World Health Organization issued recommendations against using low-calorie sweeteners for weight management.

Nonetheless, there is a deficit of extensive research on sweeteners, particularly within the framework of a healthy diet. To investigate further, Ellen Black from Maastricht University in the Netherlands monitored their effects in individuals who substituted them for sugar. She and her team enlisted 341 overweight or obese adults in Europe and provided them with a low-calorie regimen for two months, resulting in an average weight loss of 10 kilograms.

Participants then adapted to a balanced diet with less than 10% of their caloric intake from sugar. During this weight maintenance phase, 171 participants were advised to completely forgo sweeteners, while the rest were motivated to swap sugary foods and beverages for lower-calorie sweetener options. Each participant had the option to use at least 16 different sweeteners, with no limit on their usage.

After 10 months, the group utilizing low-calorie sweeteners managed an average of 1.6 kilograms more weight loss compared to the sugar group. They also exhibited a higher presence of gut bacteria that produce short-chain fatty acids—beneficial compounds previously linked to blood sugar regulation, heart health support, and weight loss maintenance.

“This indicates that replacing sugar with non-caloric sweeteners in the diet may aid in weight maintenance,” says Braak. The outcomes of this study may vary from earlier research due to its extended duration and the examination of sweeteners alongside a healthy diet, she notes. Furthermore, prior studies often focused on just a few low-calorie sweeteners, many of which were not concurrently consumed.

Regarding the differences in gut bacteria, our grasp of the microbiome is still developing, according to Elan Elinav at the Weizmann Institute of Science in Israel. Thus, it remains challenging to decipher how the changes observed in the sweetener-consuming group will influence their health. He added that it is uncertain whether these transformations stemmed from weight loss, the intake of low-calorie sweeteners, or a combination of both.

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Source: www.newscientist.com

Resistance Training Could Enhance Gut Microbiota Health

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Strength training

Strength training can support your gut microbiome

Juliana Yamada/Los Angeles Times via Getty Images

While noticeable muscle growth, like bulging biceps, is a clear advantage of weightlifting, research indicates that strength training can also be beneficial for your gut microbiota.

No singular cluster of microorganisms ensures good health, yet certain compositions are linked with enhanced medical outcomes, including a stronger immune system and healthier aging. Key players include faecalibacterium, Akkermansia, and Rose Buria Hominis, all of which generate short-chain fatty acids such as butyric acid that support the intestinal lining and combat inflammation.

While diet is undeniably significant, studies suggest that aerobic exercise—like cycling and running—can create an environment favorable for these microbial species to thrive. This may occur via improved blood flow, hormonal shifts, or metabolic by-products associated with physical activity, including lactic acid. Research on resistance training has yielded mixed results; some studies indicate significant changes, while others show negligible effects. “Current research is somewhat limited,” notes Matieu Krauss from the Norwegian Sports Science School in Oslo.

For clarity, Sven Nahnsen, from the University of Tübingen in Germany, along with his team, studied a sizable group of 150 sedentary adults who underwent an eight-week training regimen that included a variety of resistance exercises like lateral pulls, seated rows, chest presses, and leg curls.

In contrast to past research, participants utilized an “intelligent” machine that automatically adjusted weights and range of motion based on individual performance, thereby keeping a meticulous record of progress. “The data is precise as every lift is digitally documented,” shares Nahnsen.

Prior to starting, and at intervals during the program, participants submitted stool samples, which researchers analyzed for genetic and metabolic fingerprints of commonly found gut microorganisms.

Across the group, there was no average alteration in microbiome composition post-program. The outcome seemed to vary based on each individual’s training response, showing a correlation between increased intensity and microbiota changes.

High-achieving participants who reaped significant muscle strength benefits exhibited an increased percentage of faecalibacterium and Rose Buria Hominis by the program’s conclusion. “These species were more abundant in those who gained substantially more strength,” summarized Nahnsen.

The reasons why some individuals responded better to the training compared to others remain ambiguous. One might assume it relates to their effort, yet compliance levels were similar across low and high performers. An alternative explanation could be that successful participants altered their diets following their exercise routines. This lifestyle adjustment could reasonably influence both microbiota and muscle strength. However, despite attempts to account for this through dietary assessments, researchers found no substantial differences in food intake, “a factor we couldn’t completely discount,” according to Nahnsen.

Another intriguing prospect is that the microorganisms themselves may partially facilitate the improvements in strength. In high-performing individuals, changes in the microbiome may enhance the production of short-chain fatty acids, enabling muscles to better respond to the eight-week training regimen. However, Nahnsen emphasizes that this warrants further investigation.

He aspires that this research will serve as a foundation for exploring potential mechanisms. “Our goal was to establish a ‘dictionary’ of microorganisms likely affected by resistance training to assist other researchers in uncovering the mechanisms,” he stated. Strategies to promote beneficial shifts in the microbiota post-training could represent a novel approach to enhancing exercise’s health benefits and sports performance.

It’s worth noting that the trial did not include a control group of participants who remained inactive. Nevertheless, Klaus, who did not participate in the study, is optimistic about the findings. “These results reinforce the idea that exercise positively impacts gut health, regardless of the specific type, and highlight that resistance training can induce microbiome-related changes tied to specific health benefits,” he remarked. “This underscores the importance of integrating both endurance and resistance training into health promotion strategies aimed at improving microbiome health.”

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Source: www.newscientist.com

The Negative Impact of Excessive Fiber on Gut Health

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You might have come across the term “fibremaxxing.” This recent health craze, popularized on platforms like TikTok, involves individuals significantly increasing their daily fiber intake. The recommended amount is 25-30g (0.9-1 oz) per day with the goal of enhancing gut health.

Influencers are now dubbing fiber as the “new protein,” promoting high-fiber foods such as beans, lentils, whole grains, fruits, and vegetables. Some even resort to fiber supplements to meet their daily targets.

This theory suggests that such increases have potential health benefits, including improved digestion, more regular bowel movements, increased gut bacteria, and relief from symptoms associated with irritable bowel syndrome (IBS).

This trend arises from the belief that modern diets often lack sufficient fiber, and there is certainly some truth to this.

Current data indicates that 91% of individuals in the UK, and likewise in the US, do not meet the recommended fiber intake. 95% of people lack adequate fiber.

So, ramping up fiber consumption must be beneficial, right? However, it’s not that straightforward, particularly in relation to diet and health.

Intestinal Reactions

Fiber plays a crucial role in gut health for several reasons.

Though it is a carbohydrate, fiber differs from other carbs like starch and sugar; it is not digested in the small intestine. Instead, it travels to the large intestine where gut bacteria utilize it. These bacteria offer various health benefits by producing short-chain fatty acids (SCFAs) that contribute positively to our health.

Non-decomposable fibers absorb liquid, increase stool bulk, and make elimination smoother. Thus, boosting fiber intake can help prevent constipation and regulate bowel movements.

Individuals with IBS often believe enhanced fiber intake soothes symptoms, particularly if they experience more constipation than diarrhea.

Vegetables offer a variety of fibers, both soluble and insoluble, beneficial for gut health.

Research suggests that adequate fiber intake can reduce the risk of colon cancer. One SCFA produced in the large intestine, butyrate, is believed to have anti-inflammatory and protective properties for colon cells.

By facilitating stool passage, fibers minimize the contact time colon cells have with harmful substances, potentially explaining the rising incidence of colon cancers worldwide. Particularly among young individuals who consume insufficient fiber-rich foods.

Nonetheless, while incorporating more fiber into your diet is generally beneficial, “fibremaxxing” requires a nuanced understanding of nutrition. It’s akin to running a marathon without proper training for your gut.

The Risks of Overconsumption

The gut is a complex ecosystem, finely tuned to maintain balance, and introducing excessive specific nutrients can lead to unintended consequences. Some proponents of “fibremaxxing” advocate for fiber intakes exceeding 50g (1.8oz) daily, possibly resulting in side effects such as bloating, cramps, and diarrhea.

There’s also a variety of fiber types to contemplate. Soluble fibers absorb water and slow digestion, while insoluble fibers pass through largely intact, hastening digestion. Moreover, fermentable fibers feed bacteria in the large intestine.

A healthy gut requires a balance among these fibers. Excessive insoluble fiber (found in wheat bran and some vegetables) may bulk up stool but irritate sensitive digestive organs. Certain fermentable fibers, like oligosaccharides, disaccharides, monosaccharides, and polyols (known as FODMAPs), can complicate absorption and potentially aggravate IBS symptoms.

To effectively support gut health, a balance of different fiber types is essential. By aiming excessively high, such as 50g (1.8oz) daily, “fibremaxxers” might confine their diet to a limited array of fiber-rich foods.

For example, high-fiber breakfast cereals provide 12.4g of fiber per 100g (0.5 oz per half cup); to reach their lofty goals, individuals may feel compelled to consume multiple bowls throughout the day. However, cereal mainly offers insoluble fiber, lacking soluble and fermented fiber.

Consequently, excessive fiber can lead to increased digestive discomfort and disrupt the delicate equilibrium required for a healthy gut, particularly if individuals neglect to consider how to balance their nutrient intake.

Cleansing Trends

By prioritizing one nutrient for specific health benefits, fibremaxxing fits into a long tradition of cleansing and detox trends targeting digestive health.

While various gut cleansing rituals frequently trend on social media and appear enticing, they often cause more harm than good. For instance, juice cleanses can strip away vital nutrients, and “detox” teas and laxatives may result in dehydration and long-term harm to the intestinal lining.

Additionally, recent trends involving enemas can disrupt the natural rhythm of the intestines and eliminate beneficial bacteria.

Juice cleansing is neither a healthy nor a safe dieting approach.

Experts advise caution regarding trendy supplements and extreme elimination diets that exclude entire food groups without proper oversight, as these may reduce microbial diversity and impair digestion. Your gut won’t appreciate these drastic resets; what it truly needs is ongoing, careful, and balanced support.

Monitoring Your Fiber Intake

How can you determine if you’re consuming enough fiber in your diet and if you need to increase your intake?

Signs such as fatigue and weight gain are often early warnings. Soluble fiber slows digestion, contributing to prolonged feelings of fullness while gradually releasing sugar into the bloodstream.

In its absence, blood sugar levels can fluctuate unpredictably, leading to fatigue shortly after meals. Such energy dips can tempt you into snacking, resulting in weight gain.

While fibremaxxing may have begun as a sincere effort to boost well-being, like many health trends that go viral, it oversimplifies complex bodily processes and poses risks by overdoing things.

It’s evident that most individuals will benefit from increasing fiber consumption, especially from plant-based foods, which can aid digestion, lower disease risk, and help maintain healthy weight. However, this must be done cautiously; excessive, sudden, or unbalanced increases can be detrimental.

Your gut is a finely tuned ecosystem that flourishes through diversity, consistency, and balance—not through drastic changes or quick fixes.

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Source: www.sciencefocus.com

Gut Microbiota Alterations Associated with Fertility Challenges in PCOS Patients

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Restoring the levels of specific intestinal microorganisms may help treat fertility problems in people with PCOS

Science Photo Library / Alamy Stock Photo

Women diagnosed with polycystic ovarian syndrome (PCOS) seem to face a heightened risk of pregnancy complications linked to lower levels of gut microorganisms.

PCOS stands as the most prevalent hormonal disorder among women of reproductive age and is a leading cause of infertility. Yet, the underlying causes and effective management remain somewhat elusive. For instance, it remains unclear why women with PCOS who do conceive are more susceptible to complications such as miscarriage, premature birth, and gestational diabetes.

Aixia Liu from Z Jiang University in China and her research team tracked the pregnancy outcomes of 220 women across 44 cities, half of whom had PCOS. All were younger than 35 and provided blood samples as well as stool and tissue samples from the endometrial (internal lining of the uterus).

Despite having comparable pregnancy rates, women with PCOS exhibited nearly double the likelihood of facing pregnancy complications, including miscarriage, premature birth, gestational diabetes, and delivering babies with low birth weight. Furthermore, researchers determined that women with PCOS have roughly half the quantity of gut bacteria, particularly Parabacteroides merdae, which was more closely linked to pregnancy outcomes than in those without the condition.

P. merdae aids in converting specific nutrients, like the amino acid isoleucine, into beneficial compounds known as short-chain fatty acids, which are crucial for reproductive health. This likely accounts for the 39% higher average isoleucine levels in the blood samples of PCOS participants and their 10% lower levels of short-chain fatty acids. Additionally, high isoleucine concentrations were noted in the endometrial tissue.

In laboratory settings, when researchers cultured the participants’ endometrial cells and introduced isoleucine, they observed increased markers of cell senescence, indicating wear or damage in the cells that compromised their function. Isoleucine seemed to disrupt the processes endometrial cells typically undergo during pregnancy.

“These findings suggest age-related changes within the uterus,” Li remarked in a statement from the annual meeting of the European Breeding Association, where the data was revealed. “Our research points to high levels of isoleucine from P. merdae potentially impairing endometrial health, even in women under 35.”

Such results suggest that alterations in the gut microbiome could play a role in PCOS-related fertility challenges; however, Andrea Dunaif at the Icahn School of Medicine at Mount Sinai, New York, expresses skepticism. Her studies indicate that reproductive aging in PCOS is more delayed than accelerated. “Reproductive issues often improve in your 30s,” Dunaif notes. “This leads me to doubt the significance of endometrial findings and their true responsibility for pregnancy outcomes.”

Nonetheless, these insights could pave the way for enhanced fertility treatments for women with PCOS. “Where might we intervene in the microbiome and adjust with various probiotics?” Dunaif suggests.

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Source: www.newscientist.com

Common Gut Bacteria Can Transform Everyday Plastic Waste into Paracetamol

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Paracetamol, also known as acetaminophen, is a pain reliever traditionally produced from a diminished supply of fossil fuels, such as crude oil. Every year, thousands of tons of fossil fuels, alongside numerous drugs and chemicals, are utilized to transport painkillers to manufacturing facilities. Professor Stephen Wallace from the University of Edinburgh and his team discovered that E. coli bacteria can transform molecules derived from waste plastic bottles into paracetamol.

Johnson et al. Reporting the reorganization of phosphate-catalyzed loss of biocompatibility in bacteria E. coli Activated acylhydroxamate is transformed into primary amine-containing metabolites in living cells. Image credit: Johnson et al. , doi: 10.1038/s41557-025-01845-5.

The issue of plastic waste is increasingly pressing, making the quest for sustainable plastic upcycling solutions a priority.

Metabolic engineering combines organic chemistry with the exploitation of biological cell chemical reaction networks to create new small molecules.

However, it remains uncertain whether these reactions can be effectively combined to convert plastics into useful products.

“Our research indicates that polyethylene terephthalate (PET) plastic is not merely waste, but can be converted by microorganisms into valuable new products with potential applications in disease treatment,” stated Professor Wallace.

In their study, Professor Wallace and co-authors found that a specific type of chemical reaction, known as loss rearrangement, occurs within living cells and is catalyzed by internal phosphates in E. coli.

This reaction produces nitrogen-containing organic compounds that are vital for cellular metabolism.

The researchers demonstrated that chemical processes can decompose PET plastic to yield starting molecules for further reactions, allowing cellular metabolism to regenerate these plastic-derived molecules.

Additionally, they discovered that this plastic-derived compound can serve as a precursor for paracetamol production in E. coli, achieving a yield of 92%.

This finding may mark the first instance of paracetamol synthesized from E. coli waste materials.

Future research will focus on exploring how other bacteria and types of plastics can yield beneficial products.

“Thus, biocompatible chemistry should be viewed as a complement to early enzyme design research and non-biological chemistry engineering, integrating collaboratively as a tool for biological cells to enhance potential synthetic chemistry within biological systems,” the scientists noted.

The team’s study was published in the journal Nature Chemistry on June 23, 2025.

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NW Johnson et al. Relocation of loss of biocompatibility in E. coli. Nat. Chem. Published online on June 23, 2025. doi:10.1038/s41557-025-01845-5

Source: www.sci.news

Your Rectum Isn’t Made for Coffee: Insights from Dr. Probeticoc on the Latest Gut Health Trends

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When TikTok declares it’s run out of bizarre ideas, enter the world of coffee enemas.

Indeed, people are brewing fresh coffee pots and introducing them into the colon via the rectum to stimulate bowel movements. This trend claims to “detox” the body, enhance energy levels, and improve digestion.

This isn’t a new phenomenon: coffee enemas have long been associated with the Gerson Therapy diet and energy-based cancer treatments since the 1950s.

Despite its TikTok resurgence, there’s scant credible evidence supporting its effectiveness, while reports of unpleasant and potentially harmful side effects abound.

Firstly, the rectum is not meant to handle coffee. Caffeine and acids can irritate delicate tissues, leading to inflammation, pain, and possible burns if the coffee is cold enough. Over time, frequent use can damage the mucosal lining, heightening the risk of chronic issues.

Although this trend touts “detoxification,” you don’t need to resort to such risky methods, as your liver and kidneys are already efficient at eliminating toxins.

Moreover, there are significant risks associated with DIY procedures. Engaging in invasive actions can result in injuries like infections and rectal tears. Severe infections can lead to sepsis, posing life-threatening consequences.

There is no credible evidence supporting the efficacy of coffee enemas – Illustration by Jessley

Thus, if you’re seeking to feel lighter or healthier, it’s best to rely on the basics: consume more fiber, stay hydrated, and stay active. If digestion troubles persist, consult a healthcare professional rather than an influencer.

Despite its newfound popularity, reliable evidence supporting the benefits of coffee enemas is lacking, and the associated risks are significant. “Bottom” line? Enjoy your coffee in a mug, not through a colon.

This article responds to the question (I emailed Sarasolomon) “Should I try a coffee enema?”

Feel free to email us to submit your inquiries Question @sciencefocus.com or Message Facebook, Twitteror Instagram Page (please include your name and location).

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Preserving Gut Health: Using Gut-Friendly Antibiotics to Treat Lyme Disease

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Lyme disease can spread to people through mites

Heico Birth/Shutterstock

Antibiotics commonly used to absorb pneumonia remove Lyme disease mice at doses 100 times lower than standard antibiotic therapy. This small dose was combined with the targeted effect of the drug on infection, meaning that the animal’s gut microbiota was largely unaffected.

Lyme disease is caused by bacteria in the genus Borelia It spreads mostly among birds and small rodents, but people can get infected via the bites of mites that have given the blood of such animals. Infections generally lead to flu-like symptoms and a “bull” rash. Without treatment, it can cause serious long-term complications such as fatigue and pain.

Standard treatment involves taking the antibiotic doxycycline twice daily at high doses for up to three weeks. This will stop the production of the proteins needed for bacteria to survive, but will not selectively target them Borelia seed. “It will cause chaos normally [gut] It says microbiome. Brandon Footlas At Northwestern University, Illinois.

Looking for a more selective alternative, Jutras and his colleagues first tested how effective it is to have more than 450 antibiotics all approved by the US Food and Drug Administration. Borrelia burgdorferi – The most common type of lab dishes that causes Lyme disease.

They then evaluated how best-performing drugs affected the growth of harmless or beneficial bacteria commonly found in people and mouse visceral organs, such as certain strains. E. coli. This revealed that piperacillin is associated with penicillin, commonly used in the treatment of pneumonia and is the most selective target. B. burgdorferi.

Next, the researchers injected 46 mice. B. burgdorferi. Three weeks later, they treated the animals with various doses of either doxycycline or piperacillin for a week. The researchers found that mice received either high doses of doxycycline or 100 times lower doses of piperacillin, with no signs of infection.

They also analyzed stools from mice before and after antibiotic treatment and found that low doses of piperacillin had little effect on bacterial levels. B. burgdorferi In the gut, high doses of doxycycline significantly altered the gut microbiota.

This is probably due to the low amount of antibiotics, which has less impact on intestinal microbial diversity and is the target action of piperacillin. “We found that using piperacillin is targeting certain proteins. B. burgdorferiit is very efficient to kill this Lyme disease agent at low concentrations, not other bacteria, to survive,” says Jutras.

But mice can respond differently to antibiotics than people, John Ocotte at Johns Hopkins University in Maryland. For example, they often break down the drug faster, which can change its effectiveness. The Jutras team hopes to test piperacillin in human Lyme disease tests in the coming years.

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Source: www.newscientist.com

Research shows that consuming citrus fruit can help protect against depression by influencing the gut microbiome

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New research reveals a potential protective role for citrus fruits in preventing depression. Faecalibacterium prausnitzii, a type of bacteria found in the human intestine, and its metabolic activity, may influence the impact of citrus fruits and their flavonoids on mood.

Samuthpontorn et al. We report that citrus intake and its ingredients are positively associated with changes in abundance of 15 intestinal microbial species, including reduced risk of depression and enrichment Faecalibacterium prausnitzii. Image credit: Hans.

Depression is a widespread and debilitating condition that affects more than 280 million individuals around the world.

The exact cause of depression is unknown, and treatment is often ineffective.

70% of patients with depression are unable to respond to initial antidepressant treatment and experience unbearable side effects of the drug.

Diet may be a promising tool for preventing and managing depression.

Mediterranean diets are associated with a nearly 35% reduction in the risk of depression, and similar diets show a reduction in mood symptoms.

While the specific food groups underlying these findings remain unknown, recent studies have linked citrus fruits, such as oranges and grapefruits, with a reduced risk of depression.

However, the mechanisms explaining the relationship between diet and depression prevention remain unclear.

In a recent study, Dr. Raaj Mehta, a medical instructor at Harvard Medical School and a physician at Massachusetts General Hospital, along with colleagues, analyzed the interactions between citrus consumption, gut microbiome, and risk of depression in over 32,427 participants.

They prospectively examined the long-term effects of citrus intake on depression, the abundance of gut microbial species, and the potential metabolic pathways related to depression.

“I was collaborating with a talented postdoc named Chatpol Samuthpontorn. He came across a paper from 2016 suggesting that citrus fruits could reduce the risk of depression,” explained Dr. Mehta.

“This finding intrigued us, as we had access to extensive datasets that could help us investigate further.”

“One of these datasets was the Nurse Health Study II (NHS2), which began in 1989 to identify risk factors for major chronic diseases in women.”

“We found evidence in this dataset that nurses who consumed higher amounts of citrus fruits had a lower incidence of depression in the future.”

The authors found that consuming one medium orange per day could reduce the risk of developing depression by about 20%.

“When examining total fruit and vegetable consumption, or other individual fruits like apples and bananas, we did not observe a significant relationship with depression risk,” Dr. Mehta noted.

A unique aspect of this study was that a subset of NHS2 participants provided stool samples over a year for researchers to analyze.

“We used DNA sequencing results from these stool samples to identify links between citrus intake and specific bacterial species in the gut microbiota,” said Dr. Mehta.

“One bacterial species, Faecalibacterium prausnitzii, stood out.”

“People who were not depressed had higher levels of this bacterium, and consuming more citrus was also linked to increased levels of Faecalibacterium prausnitzii.”

“This bacterium may play a key role in connecting citrus consumption with good mental health.”

“We also investigated similar studies involving men, as NHS2 only included women, and found an inverse correlation between Faecalibacterium prausnitzii and depression risk scores in this group,” Dr. Mehta added.

“This raises the question: Does Faecalibacterium prausnitzii contribute to positive mood?”

“One possible explanation is that these bacteria use metabolic pathways, such as the S-adenosyl-L-methionine cycle I pathway, to influence the production of neurotransmitters like serotonin and dopamine in the intestine,” Dr. Mehta explained.

“These neurotransmitters not only influence digestion but can also travel to the brain, where they affect mood.”

“We hope our findings encourage further research into the link between diet and mental health,” Dr. Mehta stated.

“People generally understand that food can impact mood, but researchers are just starting to unravel the specifics.”

A paper detailing these findings was published in the journal Microbiome.

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C. Samuthpontorn et al. 2024. F. Prausnitzii Potentially modulates the association between citrus intake and depression. Microbiome 12, 237; doi:10.1186/s40168-024-01961-3

Source: www.sci.news

Unexpected connection between gut microbiota and quality sleep

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A bad night's sleep can be caused by many things, including screen time, stress, and drinking too much alcohol. Now, there's another culprit. It's the microorganisms in your intestines.

This article is part of a special series exploring important questions about sleep. Click here for details.

It's long been known that our microbiome has a powerful influence on our health, but new research has revealed that this extends to our sleep as well. But it's a complex two-way relationship. “The microbiome influences your sleep, and sleep influences the microbiome,” he says. elizabeth holzhausen At the University of Colorado Boulder. The good news is that there are ways we can intervene.

At first glance, the connection between your stomach and sleep patterns may not be obvious, but a growing body of research is revealing how they influence each other. For example, a 2023 study of 720 people found that: Diversity of microorganisms in the gut It was associated with improved sleep quality. Similarly, researchers at King's College London (KCL) and other institutions, in collaboration with personalized nutrition company Zoe, surveyed nearly 1,000 people and found that irregular sleep patterns are associated with sleep disorders. It turned out. Increase in the number of “undesirable” bacterial species It is associated with poor health.

Furthermore, changes in the composition of the gut microbiome are associated with several sleep states. For example, rapid eye movement sleep behavior disorder, in which sleepers physically act out their dreams during REM sleep, Decrease in intestinal bacteria It produces the short-chain fatty acid butyrate, which causes an increase in bacteria that worsens inflammation.

Source: www.newscientist.com

Gamers Uncover Traits of Human Gut Microbiota

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Scientific research revolves around solving complex problems, and so do computer games. In 2008, a group of scientists developed the first video game that allows non-scientists to aid research by solving puzzles based on real scientific data. That’s what they called the game foldit.

Since then, other scientists have developed similar games and contributed to fields such as genetics and physics. These games are collectively called: citizen science games Or CSG. Traditionally, researchers designed CSG games to focus on science elements rather than game elements. However, they report that this approach limits user engagement and primarily appeals to participants who already have a strong interest in science.

To overcome this challenge, a group of researchers from Switzerland, Canada, and the United States developed a CSG using game-first design principles. This means that they prioritized the entertainment aspect of the game before incorporating any scientific questions into it. They used this approach in their next game. borderlands science or BLS. The scientific objective of this game is to help researchers analyze the genome sequences of one million microorganisms from the human digestive system to understand their relationships and functions in human health. Scientifically, the analysis that the player was assisting with is called: Multiple sequence alignment.

The researchers used 953,000 sequenced fragments of genetic material called . 16S rRNA From human stool samples provided by participants. american gut project. These fragments are part of specific regions within the genome that are used to identify and compare different microorganisms. They first grouped the sequences into over 10,000 clusters, then removed outliers, and finally focused on a final set of 9,667 clusters for the game.

They designed puzzles for the BLS game based on sequences within these clusters. Players saw a grid of colorful bricks, each representing a DNA base such as A, T, C, or G. Their goal was to insert gaps between bricks based on unique patterns to improve matching and alignment of different colors and arrangements. – Matching skills used by humans when playing the game. Players had a limited number of moves, each level of the game had a score to clear before moving on to the next level, and players were challenged to find the best placement with as few moves as possible.

The researchers explained that they were not recruiting people to play the game. Instead, they released the game through an existing commercial video game called Borderlands 3. They noted that the game was released in 2020 and the data reported in the paper represents the first 16 months after release.

Researchers collected over 1.4 million puzzle solutions and filtered them based on how well they were ordered and how well they matched other players' solutions to keep only the highest quality ones. Ta. They combined the filtered solutions to create a composite alignment, which they used to construct a family tree showing the evolutionary relationships among gut microbes.

The team validated the results by comparing the alignment and tree to the results of existing alignment and tree construction methods. They showed that player-generated solutions outperformed these existing methods and improved their ability to infer microbial relationships. The researchers also investigated how BLS results can help detect meaningful biological patterns from these microorganisms. relationship. They reported that the BLS alignment grouped gut microbes based on several lifestyle factors, such as diabetes and alcohol intake, that influence the host's digestive health.

Researchers reported that more than 4 million participants have completed real-world scientific tasks since the release of BLS. This is a high retention rate compared to previous CSG efforts. They proposed that this BLS performance demonstrates that scientific tasks can be embedded within video games and achieve high levels of player engagement.

Additionally, the researchers sought feedback from players as part of the game's quality assurance. Players cited curiosity about science as the most common reason for participating. The team argued that a game-first design approach to developing citizen science games like BLS has benefits, including increasing scientific literacy among the public.

The researchers reported that BLS outperformed traditional sequence alignment methods in terms of scientific output without compromising data integrity. They concluded that the results showed that video games can provide the human resources needed to analyze vast amounts of genomic data that would otherwise be completed by small teams of scientists. Ta.


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Source: sciworthy.com

Are fermented foods like kimchi and kombucha truly beneficial for gut health?

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Humans have been fermenting foods and drinks for at least 13,000 years and touting their health benefits for almost as long. However, even though we have a long history with these foods, we are only just beginning to determine whether these foods are actually beneficial to our health.

But unlike our ancestors, we now know how fermentation works. Microorganisms such as certain yeasts and bacteria break down the sugars in grains, fruits, vegetables, and dairy products in ways that prevent them from spoiling and create their unique flavors. But what does this mean for our health?

This article is part of a series on nutrition that delves into today’s hottest trends. Click here for details.

Many studies have shown that fermented foods, especially dairy versions, Reduced risk of heart disease, type 2 diabetes and obesity. for example, 2023 survey A study of more than 46,000 adults living in the United States found that eating fermented foods was associated with lower blood pressure, body mass index, and waist circumference.

However, much of the research lumps all types of fermented foods together, and given the health effects of these products, it is likely that people who consume fermented foods are also more likely to take care of their health in other ways. I understand. Both of these factors make it difficult to determine what is actually driving the observed benefits.

benefits of yogurt

However, the most likely case is yogurt. Many large-scale studies have linked its consumption to: Improving immunityimprove bone density and longevity, and reduce the risk of: cardiovascular disease and high blood pressure. However, determining cause and effect from these observations…

Source: www.newscientist.com

The success of a racehorse may rely on its gut microbiome in early life

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Gut microbiota of racehorses may affect health and performance

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Racehorses who have a more diverse gut microbiome as foals appear to perform better and have a lower risk of health complications.

The findings suggest that, as suspected in humans, there are critical periods in the horse’s gut microbiome for establishing a bacterial composition that may contribute to an individual’s long-term health and fitness.

Christopher Proudman Researchers from the University of Surrey in the UK analysed DNA sequences from fecal samples from 52 thoroughbred foals born at five stud farms in 2018.

The researchers took samples nine times over the first year of life: at 2, 8, 14 and 28 days of age, and at 2, 3, 6, 9 and 12 months of age. Once the animals were a year old, they were transferred to 29 racing training centres across the UK.

The researchers then measured the athletic performance of the two- and three-year-old horses during the races, and collected data on rankings and total prize money, as well as recording the horses’ respiratory systems, orthopedic health, and soft tissue health.

The team found that greater bacterial diversity at 28 days of age was associated with better performance in the race. The researchers also detected two bacterial families: Anaeroplasmataceae and Bacillaceae was associated with having a competitive advantage.

In contrast, low bacterial diversity at 1, 2 and 9 months of age was found to be associated with an increased risk of orthopedic and other problems, such as muscle strains and “hairline” fractures. The team also found that certain bacterial families, when abundant around the first week or two of life, were associated with an increased risk of respiratory and musculoskeletal diseases later in life.

Foals treated with antibiotics (which can affect gut microbiomes) during the first few weeks of life had significantly lower bacterial diversity than untreated foals at day 28, Proudman said. These animals subsequently produced fewer winnings and developed respiratory disease at 10 times the rate of untreated foals from age 6 months onwards.

The early health problems that prompted antibiotic treatment may have actually affected later performance and health. Simon Daniels Researchers from the Royal Agricultural University in Gloucestershire, UK, say it’s realistic to think that antibiotics themselves reduce bacterial diversity, leading to poorer health and performance.

“Although more evidence is needed before any firm conclusions can be drawn, it appears that how young horses are managed is particularly important for their later athletic performance,” Daniels says.

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Source: www.newscientist.com

What insights can a home fecal test kit provide about our gut microbiome?

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Feces can reveal the bacteria in your intestines, but we don’t yet know which ones are best.

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The science of our gut microbiome is often portrayed as one of medicine’s hottest new areas, but some argue that this research is overhyped. The latest aspect of this field to gain traction is test kits that allow you to send in a stool sample to find out if your gut bacteria are impacting your health.

Analysis found that these kits made claims that were not supported by evidence and that their testing procedures were not rigorous enough. So should companies even be allowed to sell them?

Research into the microbiome began about 20 years ago, with advances in DNA sequencing allowing scientists to learn more about our bodies and the bacteria that live within them.

Doctors have long known that some infectious diseases are caused by an overgrowth of harmful pathogens. The innovative idea is that more subtle microbiome disturbances can lead to conditions normally thought to have nothing to do with our gut, such as obesity, cancer and depression. did.

Despite the hype, this field has yet to change the world of medicine. Fecal transplants (transferring one person’s stool to another’s to increase beneficial bacteria) have so far been approved for only one rare medical condition. It is a severe form of diarrhea that usually affects hospitalized patients taking strong antibiotics. Additionally, probiotic products that purport to deliver “good bacteria” to the gut have generally not yet been shown to be effective in randomized trials, the gold standard of medical evidence.

But that hasn’t stopped some companies from selling microbiome-related products directly to the public. In response, the US National Institutes of Health launched an investigation into the increased use of fecal test kits by the general public.

Diane Hoffman Researchers from the University of Maryland identified 31 companies around the world that offer direct-to-consumer microbiome analysis kits. Based on the results of these analyses, users may be provided with a comprehensive report on their gut health, for example in the form of a numerical score, or told that their gut bacteria are associated with certain medical conditions. there is.

The big problem, Hoffman says, is that the science behind fecal DNA analysis is not yet advanced enough to draw reliable conclusions. Previous research has shown that Giving the same sample to different laboratories can give different results. This may be due to differences in how samples are processed or the reference databases companies use to determine someone’s microbiome.

Companies typically do not provide details about how they conduct their analysis, considering it commercially sensitive. “They don’t have to provide any information,” Hoffman said.

A further problem is that even if we could accurately quantify how much of each bacterial species is in someone’s feces, there is still no debate among doctors about which bacteria are associated with specific medical conditions or gut health. There’s a lack of consensus, Hoffman said. “They don’t have the data they need to determine whether someone’s gut microbiome is healthy or unhealthy.”

Some of the companies selling these tests have conflicts of interest. The research team found that nearly half of manufacturers sell supplements and probiotic products that claim to improve gut health and recommend them to consumers based on test results.

The findings are not surprising. leslie hoyles He is co-author of a review on the field at Nottingham Trent University in the UK. natural microbiology Last year, it concluded that the country was susceptible to “hype and misinformation.” When it comes to fecal testing, “it varies so much from person to person that it’s meaningless,” she says. “We don’t know what a healthy microbiome is.”

It might be tempting to think that if people want to waste money on fecal test kits, they should be allowed to do so. However, many other types of direct-to-consumer medical tests, such as pregnancy tests and COVID-19 tests, are regulated by government agencies and require sufficient supporting evidence. It’s time for microbiome testing to meet the same standards, Hoffman says.

No one is arguing that microbiome research should be abandoned. Although there is great promise in this field, it is clear that it is still in its early stages. So for now, it may be wise to just continue flushing your stool down the toilet.

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Source: www.newscientist.com