One of the study participants fell asleep during the experiment.
Mia Lux
Your brain can be gently nudged to tackle complex problems in your sleep, enhancing your ability to solve them upon waking.
Neuroscientists and psychologists are increasingly employing techniques involving sound, touch, movement, and particularly olfactory stimuli to influence dreams. This innovative approach demonstrates potential for applications like helping smokers quit, treating chronic nightmares, and even enhancing creativity.
Now, Karen Koncoly and her team at Northwestern University in Illinois have revealed that this technique may also aid in problem-solving. The researchers enlisted 20 self-identified lucid dreamers—individuals aware that they are dreaming and able to control their narratives—and tasked them with solving puzzles in two sessions within a sleep lab. Each puzzle was associated with unique soundtracks, featuring soothing elements like birdsong and steel drums.
The researchers meticulously monitored participants’ brain and eye movements to pinpoint when they transitioned into the rapid eye movement (REM) phase of sleep, which is known for its vivid and imaginative dreams. Upon entering this phase, a selection of unresolved puzzles was paired with the corresponding soundtracks. Participants were prompted to demonstrate lucidity by executing at least two rapid eye movements from left to right, indicating they were aware of the sound cues while striving to solve the puzzles in their dreams.
The following morning, participants reported that those who listened to the soundtracks during sleep found the puzzle features prominently featured in their dreams, significantly boosting their chances of solving them. Approximately 40% of participants who dreamed about puzzles managed to solve them, while only 17% who didn’t dream of the puzzles could achieve the same.
While the exact reasons behind these findings remain unclear, it’s suggested that pairing sound stimuli with learning tasks while awake may activate the memory of the puzzle when hearing the same sound during sleep, through a process known as targeted memory reactivation. This appears to activate the hippocampus—an essential brain region for memory—prompting what may resemble a spontaneous reactivation of memories that facilitates learning.
Although dreams can manifest at any stage of sleep, Konkoly indicates that targeting REM sleep may enhance problem-solving capabilities. “REM dreams are highly associative and atypical, blending new and prior memories with imaginative thought,” she states. “During this stage, your brain is quite active, potentially allowing for unrestricted access to various sections of your mind.”
Researcher Karen Concoly prepares a participant for the study by fitting a cap to their head that records brain activity.
Karen Konkoly
Tony Cunningham and researchers at Harvard University affirm that this study indicates “individuals may consciously focus on unresolved issues while dreaming.”
However, some experts caution that dream engineering could interfere with the critical functions of sleep, such as clearing toxins from the brain. There are concerns about the potential for companies to exploit these findings by placing ads within personal devices, which Cunningham particularly highlights. “Our senses are already bombarded during waking hours by advertisements, emails, and work stress; sleep remains one of the few times of respite,” he notes.
Koncoly plans to explore why certain individuals exhibit varying responses to sound stimuli on different days. “During this study, I stayed up all night monitoring brainwaves and providing cues during REM sleep. Sometimes participants would signal a response, and other times, they wouldn’t. Occasionally, they would wake and incorporate relevant puzzles into their dreams, while at other times, they simply processed the sound without any further reaction. Why do identical stimuli manifest differently in the same state of consciousness?”
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Spotify has revealed a collaboration with the globe’s largest music enterprise to create “responsible” artificial intelligence tools that honor artists’ copyrights.
The leading music streaming service is teaming up with major labels Sony, Universal, and Warner to develop innovative AI solutions, featuring renowned artists like Beyoncé, Ed Sheeran, and Taylor Swift.
While Spotify has yet to disclose specifics about the new product, the company assures that artists will not be compelled to participate and that copyright protections will be upheld.
In a blog post announcing the partnership, Spotify pointedly referenced the radical views on copyright present in some segments of the tech industry. Ongoing tensions have already prompted three major labels to initiate lawsuits against AI companies that offer tools for generating music from user input.
“Some in the tech sector advocate for the elimination of copyright,” Spotify stated. “We do not. Artist rights are important. Copyrights are vital. Without leadership from the music industry, AI-driven innovations will occur elsewhere, lacking rights, consent, and fair compensation.”
Copyright, a legal protection preventing unauthorized use of one’s work, has become a contentious issue between creative sectors and technology firms. The tech industry often utilizes publicly accessible copyrighted material to build AI tools, such as OpenAI’s ChatGPT and Anthropic’s Claude.
Three key music companies are suing two AI music startups, Udio and Suno, for alleged copyright violations, alongside similar legal actions in other creative domains. Both Udio and Suno maintain that their technology aims to generate original music rather than replicate the works of specific artists.
Universal Music Group’s head, Sir Lucian Grainge, indicated in a memo to staff that the label will seek approval from artists before licensing their voices or songs to AI firms.
One notorious music deepfake emerged in 2023: “Heart on My Sleeve,” featuring AI-generated vocals by Drake and The Weeknd, was removed from streaming platforms after Universal criticized it as infringing on rights related to AI-generated content.
With 276 million paid subscribers, Spotify also announced the establishment of an advanced generative AI research laboratory to create “innovative experiences” for fans and artists. The company from Stockholm stated that these products will open new revenue avenues for artists and songwriters, ensuring they receive fair compensation for their work while also providing clarity regarding their contributions.
In conjunction with its AI initiative, Spotify is also collaborating with Merlin, a digital rights organization for independent labels, and Believe, a French digital music label. Currently, Spotify employs AI to curate playlists and create customized DJs.
Leaders from the three prominent companies welcomed the agreement, with Sony Music Group Chairman Rob Stringer noting that this would necessitate direct licensing of artists’ work prior to introducing new products. Universal’s Grainge expressed his desire for a “thriving commercial ecosystem” in which both the music and tech industries can prosper. Warner Music Group’s Robert Kinkle voiced support for Spotify’s “considerate AI regulations.”
I have been rearranging my home lately and encountered issues common among cyclists: where to store your bike? According to research, around 5.5 million individuals in the UK would cycle more if they had the appropriate space to store their bicycles at home. Specifically, 23% of flat residents and 58% of those living in detached houses struggle with finding accessible storage locations.
Fortunately, there are numerous bike storage options available, ranging from simple floor anchors in small outdoor areas to high-security sheds and designated parking zones offered by local authorities. One innovative entrepreneur even won £100,000 on Dragons’ Den for his “Space Isle” concept. Below are some of the top storage solutions I’ve discovered, suitable for both indoor and outdoor settings.
Top Bicycle Storage Solutions
Outdoor
If your bike needs to be parked outside and security is a concern (as it should be), opt for products with a solid safety rating. This indicates that they have undergone thorough testing to resist theft.
Additionally, if you’re considering a shed, be cautious: metal can become extremely hot in the sun. Avoid letting parts of the bike that may melt (like the handlebars and tires) come into contact with metal during the summer. Either strategically place fabric between the bike and metal or consider insulation.
For those with access to a front or rear garden, Asgard’s sheds offer secure, aesthetically pleasing, and durable options. Prices for a two-bike shed start at £649. I trialed the Mammoth Annex Plus E (with E-Bike charging capabilities) in my front yard. It’s been police approved and certified by the Loss Prevention Certification Board (LPCB) for security.
The Plus E can accommodate 3-4 bikes (make sure to check your bike size first). It also features optional plug sockets for charging, gear shelves, and hooks. For an additional cost, Asgard offers installation services. Initially hesitant to leave an expensive bike in my front garden, I found the shed to be incredibly secure, thanks to a five-point locking double door with two deadbolts.
The design includes ventilation to prevent moisture buildup and is spacious enough to conceal overflowing bins from neighbors. Weighing 176kg (27st 10lb), it’s quite a challenge to move.
Lifting Lid Shed
£629.99 on Shedstore£629.99 with Buy Sheds Direct
Trimital’s bike sheds are robust and well-constructed but lack fixed design and LPCB rating, requiring individual padlocks to secure them when closed. The dimensions of the 6ft 4in x 2ft 9in (193cm x 88cm) model allow it to house up to three adult bikes, and it boasts a 25-year panel warranty. This model features a spring-assisted lid that lifts both the roof and front of the shed, reducing the need to duck while loading and unloading bikes. However, managing two padlocks can be tricky during rain or when you’re in a hurry; the floors are sold separately (£89.99).
For models like the Fortress shed, special metal anchors can be affixed to solid floors with the bike locked to it.
Simple Wooden Shed
£434 at Powersheds£445 at Wicks
Numerous affordable wooden sheds start at £200-300, but investing in a higher-quality model is advisable. The cycle insurance company Bikmo recommends opting for a tongue-and-groove design, as overlapping wooden styles can warp and become vulnerable to both the weather and thieves. Internal hinges are preferable since they prevent burglars from easily removing the doors.
Positioned in the mid-range sector is Powersheds’ Apex Bike Shed, with the 6 x 2ft (183 x 61cm) model starting at £434. It can store two bikes, but remember to verify your bike sizes prior to purchase. Powersheds’ products come with a 10-year warranty, galvanized metal components, and easily accessible doors. However, the hinge is situated on the outside.
The Bike Shed Company offers high-end wooden sheds that accommodate up to five adult bicycles, along with garden shelving and custom wooden builds. The most affordable model, the Pedalbase 2, fits two bikes (again, be sure to check your bike dimensions). Both the doors and roof open and stay lifted via gas struts, making it effortless to access. There’s even a model designed to fit beside your bay window. This wood is sustainably sourced from FSC-certified forests in the UK.
On-Street Solutions
Photo: Nathaniel Noir/Aramie
While most councils do not provide public bike storage, and waitlists can be lengthy, we luckily share a cycling parking space on the street near our home. These Hemisil Shared Bicycle Huts are available in cities like London, Bristol, and Salford. Places like Brighton, Edinburgh, and Glasgow have efficient setups accommodating six bikes in the space of a single car. These bike storage spots are typically set up by councils and can be borrowed by residents. In London, one such spot averages £57.90 a year in 2022.
Their popularity is evident: Bristol introduced 40 new hangars that were nearly fully booked within 90 minutes. Waltham Forest currently has 4,305 individuals on its waiting list, with 150 new applications each month (the council anticipates offering 300 additional units next year).
You can join a waiting list or coordinate with your neighbors and local councils. If enough people express interest in CycleHoop, they may inform your council of the demand. There’s even a Jumbo Cargo Bike Model catering to non-standard cycles.
Time for Anchors!
For minimalist solutions in tight outdoor spaces like alleys, consider metal floor or wall anchors that can be secured into the ground and allow chains to loop through the bike. Check here for Safe-approved ground anchors currently available. You can also opt for a bike cover to shield your bike from the elements (details below).
Diamond Secure
£63.84 in Halford£56.99 on Amazon
Hiplok’s ANKR is on the pricier side but carries a diamond safety rating, which is the highest security classification for bike protection. For your investment, you’ll receive maximum security steel anchors for both bikes and motorcycles. The rubberized cap ensures no damage to your bicycle’s frame and is backed by a 10-year warranty—ideal if a bike thief has a determined mission or comes equipped with an angle grinder.
Silver Secure
£25 at Argos£19.99 on Amazon
Oxford Locks’ Anchor10 features secure silver-rated wall and floor anchors made from hardened steel. Its design includes bolts shielded by ball bearings, which are concealed when the locks are installed to thwart theft attempts. The manufacturer claims it undergoes a “5-minute attack test.”
Outdoor Bike Cover
Leaving your bike exposed to the elements is less than ideal, but may be necessary at times. Many Dutch cyclists do this year-round. Bike covers come in various styles and price ranges, providing an economical solution to reduce rust and wear. Budget options start under ten pounds, while premium covers for larger cycles can exceed seventy pounds. A mid-range option is often the best compromise.
Stylish Cover
£39.30 at Santa Fixy
The Bikeparka Stash is a chic, fitted cover that wraps around both the front and rear wheels of your bicycle, complete with cinch straps to prevent water accumulation. As a medium-sized bike user, I managed to fit two bikes beneath a single cover. Constructed from ripstop waterproof material, it boasts sealed seams, adjustable toggles, and brass eyelets to keep your bike snug and dry. Just be cautious on windy days—my bike once tipped over due to the cover acting like a sail, causing scratches. Additionally, there’s a cargo bike parka for £85.70 and a long-tail bike model with a seat cover priced at £79.95. For durability, using it primarily in the winter months will extend its lifespan by reducing UV damage. Bikeparka offers a one-year guarantee for sun exposure, and a colleague mentioned theirs has lasted for years outdoors compared to months of cheaper alternatives. To illustrate, think of it like leaving your tent exposed 24/7 while grappling with troublesome metal objects regularly.
Stormskin’s premium cover is robust and will adequately protect your bike; it withstands all weather except the most relentless horizontal rain. Reviewers have praised it as the best protective cover available (though it’s not particularly portable) and it features slits to allow securing directly to the bike lock. The material is up to nine times thicker than competing products and is made from 100% recycled fabric, showcasing a stylish palm print design that’s visually appealing. It does take some effort to fit all bikes under it.
Budget Options
£18.99 at Trets
The Oxford Aquatex cover is an economical choice while still being effective in shielding your bike from the weather. It comes in three sizes and can accommodate up to three bikes. Made from grade 100 polyester with double stitching, it is a straightforward option with a strong base. While spacious enough for larger bikes, this also results in more flapping in the wind. If you face issues with pigeons or similar problems, it could serve as a deterrent.
Indoor
There are plenty of hooks and shelving solutions designed to facilitate indoor bike storage. Treat your bike as a piece of art—it just may be! Many of the following options are also suitable for garages and sturdy wooden sheds.
Tire Hooks
£15 in HalffordHornitt for £15.99
The compact bike hook is simply a small piece of plastic constructed to hold your bike’s tire. The manufacturer suggests that while one wheel remains on the ground, installation is as straightforward as pushing a few screws into place. This clever and popular option permits you to line your bikes up like books on a shelf. Be sure to measure tire widths before purchasing from the five available sizes (ranging from 23-32mm to 70-81mm). Keep the tires inflated or the bike may tip. Another option could be the Clug Pro, which secures the wheel in place using strong, small threads and magnets. Mud pads can also be added to safeguard the wall.
Rubber Hook
£8.42 on Decathlon
For an affordable and versatile option that fully supports the bike, a rubber-covered hook is available at various price points. This option is recommended by this YouTuber. Attaching it to a wooden 2×4 or 2×6 baton, rather than directly onto the wall, enhances stability, longevity, and allows for more bikes within a meter, while also minimizing wall damage caused by the larger screws accompanying эти hooks.
No Drill Options
£149.99 on Cyclestore£179.99 in Halford
Topeak offers several no-drill bike storage solutions. For a compact setup, consider utilizing dual touch wedges stationed between the floor and ceiling, using an adjustable pole with a clever foot pedal clutch. You can fit two bikes stacked vertically, but depending on your bike size and ceiling height, the maximum weight capacity can reach 72kg or 18kg.
The trick is to locate the joists in the ceiling, which can be done by referencing old photographs from before your kitchen ceiling collapsed. I found mine this way. My E-Bike step-through frame was oddly shaped and too bulky, resulting in an unstable hanging position; however, my hybrid and road bikes fit without issue. They also provide a freestanding version with tripod legs, requiring a little more floor space, which gained popularity at Bicycle Expo.
Individuals with sinusitis may experience inflammation in their sinuses.
Science Photo Library/Alamy
Surgery is generally considered a last option for those suffering from chronic nasal blockages or persistent runny noses. However, it may prove to be more effective than the commonly prescribed antibiotics for this condition in certain circumstances.
Chronic sinusitis affects 9% of the global population. It arises when the sinuses—the cavities that produce mucus—become inflamed. Typical symptoms include nasal blockage or discharge, a diminished sense of smell, and facial pain lasting over 12 weeks. The specific cause is often unclear, although it can stem from viral infections or alterations in the nasal microbiome.
The primary treatment typically starts with anti-inflammatory nasal sprays and daily saline rinses. If symptoms persist, doctors may prescribe a three-month course of clarithromycin, utilized more for its anti-inflammatory effects than its antibacterial action, according to Carl Philpott from the University of East Anglia, UK.
As a last resort, patients may undergo surgery to enlarge their sinuses or to remove benign growths, such as polyps. This approach is needed in approximately 5% of cases. Nonetheless, no prior studies have directly contrasted the outcomes of surgery with those of antibiotics.
To address this gap, Philpott and his team enrolled over 500 adults with chronic sinusitis. Participants evaluated the severity of 22 symptoms, including facial pain and nasal congestion, averaging a score of 55 out of 110.
Participants were then randomly assigned to either a three-month regimen of clarithromycin, placebo pills, or surgical intervention. All were also instructed to use nasal sprays and conduct saline rinses.
Six months later, those on clarithromycin or placebo reported a symptom severity reduction of around 10 points compared to their baseline scores. According to Claire Hopkins from King’s College London, the improvement was noted in both the antibiotic and placebo groups, indicating it was likely due to nasal spraying and rinsing.
Conversely, the surgical group experienced a symptom improvement of approximately 30 points compared to their pre-surgery state, suggesting that such procedures should be prioritized over antibiotics, Hopkins believes.
However, there are significant factors to consider. Around 80% of the participants had nasal polyps and might have been at risk of contracting coronavirus during the study, as it was conducted amid the Covid-19 pandemic. Hopkins states that this type of inflammation often leads to polyps. More research is required to determine if the findings apply to those without polyps, who may experience different inflammation types.
When thick oil from tanker or pipeline accidents infiltrates the ocean, the clean-up process often generates more waste than oil removed. Traditional synthetic tools, such as polypropylene pads and oil dispersants, consist of toxic chemicals that decompose slowly. To offer a more eco-friendly solution, scientists are looking to natural materials like coconut shells, which can absorb oil without causing additional contamination. This Bio-based material is safe and decomposes naturally without harming the environment.
One category of bio-based materials under investigation for oil spill clean-up consists of long chains known as repeating molecules polymers. Researchers have combined various bio-based polymers to create what are called hybrid materials Composite Materials. These composites include a unique type of highly porous solids primarily made of air—Air Gel. Depending on the material composition, iPhone-sized aerogels can weigh less than small paper clips and are highly porous, allowing them to absorb significant amounts of oil, functioning like an overactive sponge!
Previously, scientists utilized chitosan (CS) derived from crustacean shells to construct bio-based aerogels with sodium alginate (SA) from brown seaweed. However, both CS and SA are water-attracting compounds, Hydrophilicity, causing them to dissolve in water. This makes it challenging to apply them for oil spill clean-ups in bodies of water, as they dissolve before capturing much oil. Additionally, CS-SA aerogels tend to be relatively weak and flexible, raising concerns about their reusability.
To address these issues, researchers at the National University of Singapore developed a new CS-SA aerogel. This enhanced aerogel not only repels water but is also lightweight, durable, and reusable through multiple oil absorption cycles.
To create the aerogels, researchers initially dissolved CS and SA in a solution and sent sound waves through it. The sound waves intertwine polymer chains, releasing and reassembling them into smaller chains of Nanofiber. To counteract the hydrophilic nature of CS and SA, researchers introduced water-repelling agents—Hydrophobicity chemicals such as Methyltrimethoxysilane or MTMS.
The mixture was then poured into a mold and placed in liquid nitrogen. This facilitated the formation of ice crystals within the solution, pushing the nanofibers towards the edges where they bonded to create honeycomb-like microstructures. The researchers then froze the mixture and directly sublimated it into steam to eliminate the water.
After producing the aerogels, researchers assessed their porosity and strength. They employed a high-powered microscope to examine the internal structure of the aerogels and determine how the nanofibers influenced porosity. They discovered that aerogels containing nanofibers are more porous than those without. An increase in nanofiber concentration from 0.5% to 2% resulted in aerogels that are up to 9.5 times stronger, albeit with lower porosity, increasing density by 2.5 times. The team settled on a 1% nanofiber concentration as the optimal formula to balance strength and porosity.
The researchers also evaluated the strength of each aerogel by stretching them and measuring how much deformation they could withstand without losing their shape—a concept referred to as Top yield strength and the force they could handle before failure—Ultimate strength. With increasing amounts of MTM, the aerogels became stronger, boosting yield strength by up to 300% and ultimate strength by 200%. They also tested the recovery of the aerogels after compression, showing that they could regain up to 96% of their original shape and exhibited 32% resilience to compression, with minimal bending or structural deformation.
Finally, researchers examined how effectively the aerogels repelled water and absorbed oils. When placed on the aerogel’s surface, water droplets retained a nearly spherical shape instead of spreading out. The droplets were observed moving across the surface and rolling off without leaving any residue, confirming the hydrophobic nature of the aerogel. To test oil absorption, researchers submerged the aerogels in an oil-water mixture, where the aerogels absorbed more than 90% of the oil volume and weighed 30-90 times their initial mass.
Researchers concluded that their new aerogels could be a powerful and sustainable alternative to synthetic materials for oil spill clean-up. They emphasized that designing materials at multiple scales—ranging from molecules to small fibers—can enhance their strength and performance. They proposed that further advancements could allow these aerogels to support reusable and eco-friendly solutions for oil spill remediation, particularly in sensitive coastal areas.
The intrigue surrounding the hacking deepens as researchers unveil new evidence indicating that two additional journalists were targeted by the same military-grade spyware utilized by Italy against activists.
Earlier this month, a parliamentary committee supervising the intelligence reporting agency confirmed that Italy employed mercenary spyware developed by Israel-based Paragon Solutions against two Italian activists.
Nevertheless, the same committee, which initiated an inquiry into the hacking scandal in March, stated that it could not ascertain the identities of those responsible for targeting prominent Italian investigative journalist Francesco Cancellato.
In a recent report from Citizen Lab researchers, Ciro Pellegrino, a close associate of Cancellato and head of the research outlet’s fan page, revealed that the Naples Bureau was also targeted by users of Paragon Solutions’ spyware. The Civic Research Institute reported that a third journalist, described as a “prominent European journalist,” was similarly targeted by the spyware.
This development unfolds as Paragon and the Italian government face mounting public scrutiny. Haaretz reported this week that Paragon offered to assist the Italian government in investigating the Cancellato incident; however, Italy allegedly declined the offer, with the Italian Security Agency expressing national security concerns.
The office of Meloni did not respond to requests for comment. A debate on this matter, which has sparked outrage between the Italian opposition and Brussels MEPs, is slated for June 16th in the European Parliament.
The Guardian sought comments from Paragon regarding the latest updates and referenced communication to Haaretz, where they confirmed that they had terminated their contract with the Italian government following the revelation in February that Cancellato had been targeted. The Guardian initially reported on Paragon’s contract termination with Italy in February.
Like other spyware vendors, Paragon markets cyber weapons to government clients, ostensibly for crime prevention purposes. The company asserts that it sells spyware exclusively to democratic nations and prohibits its use by journalists or members of civil society.
So, who is behind the targeting of the two journalists?
“We’ve noticed considerable efforts to reassure our customers,” stated John Scott-Railton, a senior researcher at Citizen Lab. “The journalists’ devices displayed a clear digital fingerprint indicating Paragon’s involvement. It became even more intriguing, as we found fingerprints in both instances that corresponded to the same Paragon clients.”
A report from the Copasir Parliamentary Committee disclosed that Italy’s domestic and foreign intelligence agencies had contracts with Paragon in 2023 and 2024, with the hacking software being used under prosecutor authorization. The committee noted that the spyware was deployed to investigate fugitives, suspected terrorism, organized crime, fuel smuggling, and anti-smuggling operations.
It also mentioned that pro-immigrant human rights activists like Luca Casarini and Giuseppe Caccia were surveilled not for their human rights work but due to their connections with “irregular immigrants.”
Treatment offers protection to mice against venom from common taipans and various other snakes
Matthijs Kuijpers/Alamy
Antibodies derived from inflammatory men exhibit effectiveness against a range of snake bites, suggesting that a universal treatment may soon be achievable.
The use of non-human antibodies, however, can lead to serious adverse effects, including potentially fatal allergic reactions. Additionally, it necessitates the identification of the specific snake responsible for the bite before administering the anti-venom.
Jacob Granville from Centivax, a biotechnology firm in San Francisco, California, is exploring broadly neutralizing antibodies that could be developed into anti-venoms effective against multiple or all venomous snakes. “There are 650 venomous snake species, but their venoms involve just 10 common classes of toxins,” Granville explains.
Researchers began investigating individuals bitten multiple times by different snakes. “Perhaps a daring snake researcher,” remarks Granville. Media reports introduced the story of Tim Friede, who claims to have “self-administered escalating doses of venom from the world’s deadliest snakes over 700 times.”
“If anyone could yield a wide-ranging neutralizing antibody against snake venom, it would be Tim Friede,” Granville affirms.
From just 40 milliliters of Friede’s blood, the team “converted immune memory into a library of billions of antibodies,” he adds. They subsequently tested promising candidates against venom from 19 of the deadliest Elapidae family species, including several cobra varieties.
Ultimately, they treated two antibodies derived from Friede’s blood, known as LNX-D09 and SNX-B03, along with a toxin inhibitor named varespladib. In experiments on mice, this combination provided comprehensive protection against 13 species, including various cobras, the tiger snake (Notechis scutatus), and the general Thai bread snake (Oxyuranus scutellatus). It also offered partial protection against six additional species, including the notorious death adder (Acanthophis Antalcus).
The subsequent phase involves testing these treatments on animals brought into Australian veterinary clinics following a snake bite and identifying antibodies that can confer protection against vipers.
Tian Du from the University of Sydney emphasizes that “discovering two antibodies that can inhibit toxins makes for a universal treatment for closely related species.”
Additionally, after learning that the anticoagulant drug heparin can assist individuals in avoiding limb loss following a cobra bite, Du aims to determine whether their treatment can also avert skin and muscle necrosis.
This year, from the first civilian moon landing (see “Elon Musk-led private missions boom, space is on sale in 2024”) to the first pig kidney transplant into a living human. It will be remembered for many pioneering events. Unfortunately, another dark first looms in 2024. Although the numbers will not be officially confirmed until next month, it is very likely that this will be the first year in which the totemic climate goal of 1.5 degrees Celsius of global warming is exceeded. (see “For the first time in 2024 reached 1.5°C, accelerating climate disruption.”)
Let’s clarify what this means. This number is generally considered to refer to a 20-year average, so it does not violate the 2015 Paris Agreement, the world’s most important climate change treaty. Under the agreement, each country commits to limiting long-term temperature rise to below 1.5°C. Nor is this a sign that the world is doomed and that we should give up all hope of combating climate change. Because if we lower temperatures even a little bit, billions of people will be better off than they would be if we didn’t do so. But reaching this level of warming, even in just one year (so far), is undoubtedly a global failure.
Breaking through 1.5°C also comes as the world enters a new and uncertain phase of climate change. As we have reported throughout the year, extreme warming in 2024 (which will only be matched by 2023) has scientists increasingly concerned about changes in major ocean currents, leading to unexplained levels of warming. They are desperately trying to understand what’s going on with the decline of Antarctic sea ice.
If you start the new year with a feeling of anxiety, you will inevitably feel pessimistic, but that may not be a bad thing. Next year will mark 10 years since the Paris Agreement came into force, and even then it was clear that the 1.5°C target had reached its achievable limits. As we wrote in our year-end leader at the time: “An odd call to action. The goal of capping global warming at 1.5°C looks almost completely unattainable.” In fact, greenhouse gas emissions Reshaping the modern world to stop and achieve net-zero emissions is the most ambitious goal ever set by humanity.
You can’t take good photos if you’re pessimistic. Ask, “What happens if I fail?” “What if we’re wrong?”
Given the scale of the challenges we face, such ambition is essential, but it is not sufficient. It’s easy to set ambitious and optimistic goals like the Paris Agreement, and politicians can line up to take pictures, smile and shake hands. It feels warm and fluffy.
However, to achieve such a goal, pessimism must prevail. You can’t take good photos if you’re pessimistic. The question is, “What happens if we fail?” and “What if we are wrong?” – Issues to be addressed include grappling with deep uncertainties in the green transition, whether technological, social or economic. Failure to do so will lead to failure.
There are lessons to be learned from success in 2024. Space engineers and surgeons alike tend to assume mistakes when considering the complexity of moon landings and complex surgeries. To alleviate this, they use a simple tool: the Humble Checklist. By identifying points of failure and taking steps to avoid them, you greatly increase your chances of success.
Although it makes less sense to have a “climate checklist” given that we are talking about ongoing global processes rather than a single operation or space mission, the underlying spirit still applies. Masu. One of the major failings is the annual United Nations climate change talks. At the 29th COP Summit held in Azerbaijan this year, organizers hailed fossil fuels as “God’s gift.”
COP30, scheduled to be held in Belem, Brazil next November, will be an opportunity to reset attitudes. Brazilian President Luiz Inacio Lula da Silva is already making noise in this direction, promising a “COP to change direction,” but will he be able to make it happen? Perhaps the most powerful message he can send is to take to the stage, stand aside unsmiling world leaders with clear plans to do better, and publicly acknowledge the failures of the COP process so far. That’s probably true. However, Santa doesn’t necessarily grant your wishes.
A degree of repentance and pessimism could also help with another problem that is quietly brewing in 2024: the imminent threat of an avian influenza pandemic. ). The H5N1 virus has spread to U.S. dairy herds despite minimal surveillance and mitigation efforts by U.S. health officials. As a result, the number of people infected there has also increased, reaching more than 50 people at the time of our reporting.
The virus has not yet adapted well to humans and is not known to be transmitted from person to person so far, but random mutations may change the situation with each new infection. increases. Optimistically rolling the dice and hoping for a double six is not good health policy. In an ideal world, the United States would already be planning for the possibility of a pandemic and sit back and watch it never materialize. We do not live in an ideal world as President-elect Donald Trump endorses vaccine skeptic Robert F. Kennedy Jr. for Secretary of Health and Human Services. That means other countries will need to come up with their own plans. This is the only rational response to uncertainty.
Obviously, this pessimism doesn’t stem from any particular holiday spirit. However, through these two issues, new scientist From the science of believing in Santa (see ‘Believing in Santa Claus doesn’t guarantee children will behave well at Christmas’) to the quest for the world’s largest snowflake (see ‘The plan to create the world’s snowflake’), there lies a world of festive feasts. The biggest snowflake was humbled by nature”).
Looking ahead to next year, I’d like to thank researchers and companies who are developing new ways to tackle climate change, from sucking carbon dioxide out of the air to genetically modifying food to make it more environmentally friendly. Raise a glass of water too. For more information, see the next issue’s 2025 preview). And we hope that the uncertainty caused by this year’s climate news will be a catalyst for change.
aAt some point, most mobile games will die. Apple’s iOS software updates have removed thousands of App Store games over the years. Old games simply disappear unless developers make them compatible with all new devices and software. (Most games can’t or won’t devote such resources to it.) Also, in the case of live mobile games that encourage users to log in every day, the popularity of the game will inevitably decline and the developer will stop updating it, leaving the game sluggish and unplayable. Sometimes there is no warning. Games exist one day and disappear the next. A truly dark fate.
Mobile gaming has a high mortality rate. 83% of them Research shows that most games fail within the first three years. But maybe there’s another way. In 2017, Nintendo released a mobile version of its best-selling relaxing life simulation game, Animal Crossing: New Horizons. The service, called Pocket Camp, ran for seven years before Nintendo ended support for it last month. But instead of ending the game, the company released a complete version for £8.99 that packages years of content and allows players to transfer data to keep their memories or start anew. The game lives on.
Pocket Camp is an excellent replica of the console Animal Crossing games, closer to a Happy Home Designer spin-off with a lighter touch than the DS and Switch versions. Your super cute character will be in charge of the campsite and decorate it with furniture and cuteobjects. If your campsite is set up to their liking, the animals will come hang out and talk trash with you. You can gift them anything you find lying around, such as fruit, fish you catch, or, better yet, live insects. Guitar-playing dog KK Slider (who, interestingly, is a caricature of Kazumi Todaka, one of Nintendo’s composers) performs at a campfire concert.
The main difference between Pocket Camp and, say, Animal Crossing on Switch is that there’s no cold in Pocket Camp. Performing insignificant missions, collecting more materials, and crafting more things will always bother you. As is tradition in mobile games, you get some kind of reward every few minutes, and every action in the game is tracked in some kind of progression tree to encourage you to keep playing. Twelve currencies, tasks, locations, and seasonal events are possible at any given time. However, it is nevertheless surprisingly feature-rich. There are thousands of things to make and buy, and hundreds of animal villagers to befriend. It feels luxurious for £8.99.
Ironically, Pocket Camp would be significantly better without the insidious monetization that was used to power it. I’ve dipped in and out of this game over the years, especially when I was waiting for 2020’s New Horizons to come out, and I’ve always loved the ubiquitous countdown timer and the daily (or several) I always shied away from it because of the manufactured urgency of logging in. 1 day) Achieve your goals. Hurry up, it’s time to harvest the fruits! Look, this special event is almost over! Don’t you want limited edition items? Don’t you want to buy some leaf tokens to speed up the creation of all this? This is a standard issue in live mobile games, but even if the game itself has value, it can also be very annoying.
All of these monetization system traps still exist in Pocket Camp Complete. They are built into the game design. However, we now give away all leaf tokens, bells, and items that you previously had to wait for or pay for for free. This changes the pace of the game and allows you to play as many times as you like at once without any restrictions. Now, without warning, I can recommend the affordable Animal Crossing: New Horizons.
More developers should do this. Once you’re done with your live games, simply package everything up and sell it for a single price. This happens in the console world, where the “Game of the Year” edition delivers the old game and all its bonuses and extra content. In this way, those who were there for the first life of the game can somehow preserve it. And such games may find new players even in the afterlife.
what to play
Fashion forward…Infinity Nikki. Photo: Epic Games
dress up fairy tale adventure infinity nikki This game, released this week, is one I’ve had my eye on for a long time because there doesn’t seem to be anything else out there. There’s no combat here, but instead there’s music, fishing, balloon rides, and conversations with cats and frogs. Pink-haired Nikki is very fashion conscious and almost everything she does in her world earns her new components for various amazing outfits. It’s an interesting combination of saccharine sweetness and downright weird, and is actually similar to Animal Crossing.
Please note: This is a free-to-play game, so if you have teenagers who want to play, make sure their settings are locked, as you could actually drop hundreds of pounds on a virtual dress. Please check.
Available: PC, PS5, smartphone Estimated play time: 10 hours or more
what to read
Mobile games in particular have been accused of violating rules regarding the use of loot boxes. Photo: Blizzard Entertainment
The BBC estimates that 43 of the top 45 best-selling mobile games are break the rules Regarding disclosure of randomized information loot box in their advertising. Regulators have been slow to take action on these gambling-related features.
devolver digital has belatedly postponed some games to next year (including Baby Steps, which I’m really looking forward to). I exhaustedly applaud Devolver for the way they presented their presentation through a mock awards ceremony. 15th Annual Devolver Delay Awards 2024.
to celebrate PlayStation 30th anniversarySony has released a set of past PlayStation launch animations, including the PS1’s iconic and incredibly 90s theme. Kotaku has more.
Astro Bot is an upcoming platform game for PlayStation 5 by Team Asobi. Photo: Sony/Team Asobi
Now it’s my turn to ask a question instead of the reader’s. you.
We’re still looking for Pushing Buttons readers to submit their favorite games of 2024. That game will be featured in the final newsletter of the year. From Baldur’s Gate 3 to Astro Bot, send us a few sentences about what they mean to you. You will see results within a few weeks.
Please reply to this email or email pushbuttons@theguardian.com.
Alzheimer’s disease is, understandably, one of the most feared diseases of old age. It robs people of their memories, places a tremendous strain on caregivers, and imposes a huge economic burden on both individuals and society. Tens of millions of people have already been diagnosed with Alzheimer’s, and if predictions are correct, that number will more than double by 2050.
Until recently, it seemed there was no hope of averting this catastrophe, but rapid advances in medical science have made it realistic prospects that Alzheimer’s may be treatable and eventually eradicated (see “A new kind of vaccine could lead to Alzheimer’s eradication”).
The first of a new class of drugs is already creating buzz, but not necessarily for the right reasons. Last week, the UK’s Medicines and Healthcare products Regulatory Agency approved the drug, called lecanemab. But NICE, the body that advises on whether new treatments are cost-effective, has made a provisional decision that taxpayers will not fund the drug in England. No decision has yet been made in the rest of the UK.
This is obviously a tough pill to swallow for Alzheimer’s patients and their families. But in the grand scheme of things, this is good news. Lecanemab is not a particularly effective drug. Its effects are modest, it has serious side effects, and it is expensive. But it does show that the causes of Alzheimer’s are now understood and treatable. This is further reinforced by the fact that the drug is also approved in the United States and Japan, but the European Medicines Agency has refused to approve it.
So the way is almost paved for the next wave of drugs to target the causes of Alzheimer’s, which could be ready around 2030. These are vaccines, not in the traditional sense of conferring immunity against an infection, but they work in essentially the same way, by stimulating an immune response against the misfolded proteins that cause the symptoms of Alzheimer’s. The first vaccines will be therapeutic, slowing or stopping the progression of Alzheimer’s, but the next generation will be preventative, preventing the onset of Alzheimer’s. Eventually, the only memory that will fade will be Alzheimer’s itself.
Many people experience uncomfortable sensations like abdominal bloating or pressure.
You may notice your stomach feeling bloated or tighter than usual, hear strange noises, or feel the need to pass gas more often. While bloating is usually harmless, it can be unpleasant.
There are numerous causes of abdominal bloating, from dietary habits to underlying medical conditions. Excess gas in the digestive tract, which occurs when air is swallowed along with food or drink, is a common cause.
Moreover, certain foods and beverages can lead to gas formation during digestion, such as carbonated drinks, beans, broccoli, sprouts, and cabbage. This gas accumulation in the digestive system can result in bloating, exacerbated by factors like chewing gum, sweeteners, alcohol, caffeine, and protein supplements.
Digestive issues like constipation or irritable bowel syndrome (IBS) can also contribute to abdominal bloating. When stool becomes trapped in the colon, it can cause discomfort and bloating. Similarly, individuals with IBS may experience bloating in conjunction with abdominal pain, diarrhea, and constipation.
To address bloating, start by identifying trigger foods through a food diary and eliminating them from your diet. Opt for a fiber-rich diet consisting of whole, unprocessed foods like fruits, vegetables, whole grains, and legumes. Probiotic-rich foods like yogurt and kefir can aid digestion and reduce gas.
In addition to dietary changes, consider incorporating herbs and spices like ginger, peppermint, and fennel to alleviate bloating. Lifestyle adjustments such as eating smaller meals, chewing food slowly, staying hydrated, and engaging in regular exercise can also help combat bloating.
If bloating persists, especially with accompanying symptoms, it is advisable to consult a doctor as it could rarely indicate ovarian cancer, particularly in women over 50.
Written by Natasha Reid of Lincoln, this article addresses the question of why individuals may feel bloated.
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There are TikTok hashtags with millions of followers, endless columns about celebrity waistlines, and a flurry of media coverage when test results come out. It is rare for a new drug to receive so much attention. However, it is even more rare for approved drugs to cause safe and rapid weight loss with minimal effort.
A year ago, most people had never heard of semaglutide. Semaglutide is a drug developed about 10 years ago under the brand name Ozempic to treat type 2 diabetes. It was later approved as a weight loss aid in the US in 2021 under the name Wegovy. With this drug, people can lose a whopping 15% of their body weight.
The impact of this new class of medicines could be unprecedented and could end the world's growing obesity epidemic. “I don’t think it’s fully sunk in yet,” he says. Jonathan Campbell At Duke University in North Carolina, he studies how these drugs affect the body.
First, Wegovy was just the beginning. The next generation of these drugs is in development and will be cheaper, easier to use, and, importantly, even more powerful. Additionally, new evidence suggests that Wegovy and its similar products are more effective when given at a younger age, so doctors are considering their use in teenagers and young children. This increases the possibility of switching from obesity treatment to prevention. “Over the past 40 years, we have seen the obesity landscape change dramatically,” Campbell says. “Now we may be at a tipping point where that goes backwards.”
Why is obesity on the rise?
The rise in obesity has been occurring since the 1970s…
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