Extreme heat and poverty can hinder child development
Riccardo Renato Niels Mayer/Alamy
Research indicates that young children exposed to extreme heat typically exhibit a reduced vocabulary, with fewer words, letters, and numbers understood, suggesting that global warming could negatively affect early human development.
Specifically, when average monthly maximum temperatures reached 32°C (90°F) or higher, children aged 3 and 4 were 2.8 to 12.2 percent less likely to meet developmental benchmarks compared to those in environments with maximum temperatures below 26°C (79°F).
“This marks the first instance in literature demonstrating that excessive heat influences not just physical health but also developmental capabilities,” stated Jorge Quartas from New York University.
Quartas and his team analyzed data from 19,600 children surveyed by UNICEF across Georgia, Gambia, Madagascar, Malawi, Sierra Leone, and the State of Palestine, referencing the early childhood development index. They assessed children’s abilities in naming letters, reading simple words, and recognizing numbers from 1 to 10.
The researchers correlated this data with climate records while adjusting for variables such as poverty, maternal education, and baseline temperatures. Notably, even temperatures of 30°C (86°F) began to adversely affect literacy and numeracy skills, with heat also impeding children’s social, emotional, and physical development to a lesser degree.
“Minor effects in early childhood can become more pronounced over time,” Quartas explains. For instance, children who struggle with number recognition might find it challenging to learn math concepts, potentially falling behind academically.
Heat-related stress remains the primary cause of weather-related fatalities, claiming nearly 500,000 lives annually. A recent rapid assessment estimated that the heatwave in June and July was responsible for 2,300 deaths across 12 European cities, primarily occurring among those aged 65 and older.
The findings also revealed that the impacts of heat extend even to prenatal periods. For instance, temperatures of 33 degrees Celsius (91 degrees Fahrenheit) during early pregnancy correlated with a 5.6% reduction in the likelihood of successful childhood development.
Children from poorer, urban households with limited access to water resources were found to be more heavily affected by the heat. “Climate change and excessive heat serve as amplifiers of existing threats,” Quartas articulated. “These children are already at a disadvantage.”
Nonetheless, the study may not comprehensively address barriers such as violence and political instability, which can also impede childhood development, as noted by Giulia Pescarini from the London School of Hygiene and Tropical Medicine.
Further investigations are needed to clarify how heat impacts development, she suggests, noting that low-income households might lack air conditioning, and parents may experience increased stress during heat events.
Pescarini emphasizes that a better understanding of who is affected and how can aid in developing adaptive strategies to support these vulnerable groups.
Innovative vaccines may provide a new approach to combat severe food allergies
Tartesy / Alamy
Researchers have developed an experimental vaccine that successfully protects mice from anaphylaxis, a potentially life-threatening allergic reaction, for at least one year. There is optimism that this vaccine will also be effective in humans.
Anaphylaxis poses a persistent threat to millions worldwide, particularly for individuals allergic to foods like peanuts and shellfish. In the UK alone, around 6% of adults, or about 2.4 million people, are believed to have clinically confirmed food allergies.
Allergic reactions can occur from consuming contaminated food or even from kissing someone who has recently eaten the allergenic food. This triggers a surge of immunoglobulin E (IgE) antibodies, leading to symptoms such as throat swelling, breathing difficulties, and a drop in blood pressure. Despite having an epinephrine auto-injector (like an EpiPen) at hand, many still need emergency treatment, and severe cases may be fatal.
Currently, avoiding allergens is the primary method of prevention, with limited alternatives available. Individuals can consider oral immunotherapy, where the allergen is gradually introduced under supervision to build up tolerance. There is also an anti-IgE monoclonal antibody drug, like omalizumab, which binds to IgE to block allergic responses. However, omalizumab is costly and requires injections every few weeks, sometimes indefinitely.
Recently, Laurent Reber and colleagues at the Toulouse Institute of Infection and Inflammation in France developed a vaccine named IgE-K. This vaccine encourages the immune system to produce antibodies that target IgE, preventing it from attaching to receptors on immune cells and averting severe allergic reactions.
“Our goal was to create a long-term solution, as individuals with food allergies face unintentional exposure at any time, necessitating ongoing protection,” says Reber.
In experiments with mice engineered to produce the human variant of IgE, the team discovered that two doses of the vaccine led to the generation of neutralizing antibodies against IgE.
“It blocks the molecules responsible for allergic reactions,” says Josh Koenig from McMaster University in Ontario, Canada.
Upon exposing the mice to a substance that triggered an allergic reaction, the unvaccinated mice experienced significant reactions, while the vaccinated mice exhibited no symptoms and were shielded from anaphylaxis for up to a year.
“It might last longer, but we have yet to conduct further testing,” noted Reber.
IgE forms part of the immune system, activated in response to toxins and certain intestinal parasites apart from allergens. “This mechanism is likely an evolutionary adaptation to combat toxins,” suggests Lever.
Lever asserts there is strong evidence supporting the long-term safety of targeting this molecule, as many individuals with severe allergies have been on anti-IgE therapy for years without negative effects. To assess if reducing IgE would diminish the body’s protective response to parasites, further tests were conducted on mice. The results indicated that the vaccine did not hinder their immune response to infections involving mouse feline, a parasitic nematode.
Koenig expresses hope regarding the vaccine’s efficacy in humans. “Research shows that the mouse-generated antibodies attach effectively to human IgE molecules. If humans can produce similar antibodies, there’s a promising chance it will be highly effective.”
Despite this optimism, Lever emphasizes that clinical trials are necessary to assess the vaccine’s safety, effectiveness, and duration in humans. If it can be commercialized, it may provide a cost-effective treatment alternative for individuals with severe allergies, requiring far fewer injections than anti-IgE monoclonal antibodies such as omalizumab.
According to a recent study, severe and long-lasting river droughts, lasting over 85 years each, impacted the Indus basin from 4,400 to 3,400 years ago. This finding may provide insights into the gradual decline of this ancient civilization and underscores how environmental factors can influence historical societies.
An artist’s reconstruction of the gates and drainage channels of the ancient city of Harappa. Image credit: Chris Sloan.
The Indus Valley Civilization, one of the earliest urban cultures, thrived between 5,000 and 3,500 years ago along the Indus River and its tributaries in present-day Pakistan and northwestern India.
During its zenith, around 4,500 to 3,900 years ago, the civilization was noted for its advanced urban centers and sophisticated systems for managing water resources.
Despite this, the reasons behind the protracted decline following its peak remain largely elusive.
“The Indus River played a crucial role in the growth of the ancient Indus Valley civilization by offering a consistent water source for agriculture, trade, and communication,” stated Dr. Bimal Mishra from the Indian Institute of Technology Gandhinagar and his colleagues.
“Civilizations prospered near the Indus River and its tributaries approximately 5,000 years ago and evolved over time.”
“The mature Harappan phase (4,500 to 3,900 years ago) was marked by meticulously planned cities, advanced water management techniques, and an intricate writing system.”
“However, post 3,900 years ago, the Harappan civilization began to deteriorate and eventually fell into decline.”
“The causes for this decline are still under discussion. Potential factors encompass shifts in river dynamics influenced by climate change, ocean retreat, drought, flooding, and alterations in social and political structures.”
“Understanding ancient hydroclimatic events and their impact on societies provides vital insights into the susceptibility of complex societies to environmental pressures.”
For this research, the authors simulated climate patterns in the Indus Valley from 5,000 to 3,000 years ago.
They integrated these findings with various indirect climate indicators, including the geochemistry of stalactites and stalagmites from two caves in India and water level data from five lakes in northwestern India.
The results indicated that temperatures rose by approximately 0.5 degrees Celsius during this time, while average annual precipitation in the region decreased by 10% to 20%.
They were able to identify four significant drought periods lasting over 85 years between 4,450 and 3,400 years ago, impacting 65% to 91% of the Indus Valley area.
“These droughts affected the selection of settlement locations in the Indus Valley Civilization,” the researchers noted.
“From 5,000 to 4,500 years ago, settlements were primarily situated in regions with abundant rainfall.”
“However, after 4,500 years ago, they shifted closer to the Indus River as drought conditions began to limit water availability.”
“The last identified drought, lasting 113 years from 3,531 to 3,418 years ago, corresponds with archaeological evidence of significant urbanization in the Indus Valley Civilization.”
“Instead of collapsing abruptly due to sudden climate changes, the Indus civilization likely faced a gradual decline, with extended drought being a key factor,” concluded the researchers.
Their study was published on November 27 in the journal Communication Earth and Environment.
_____
H. Solanki et al. 2025. River drought forcing Harappan metamorphosis. Communication Earth and Environment 6,926; doi: 10.1038/s43247-025-02901-1
Severe, poorly controlled asthma might increasingly be managed with monthly injections
Jacob Wackerhausen/Getty Images
Individuals suffering from severe asthma often depend on daily steroid medications, raising their likelihood of diabetes, infections, and bone issues. A new study indicates that monthly antibody injections could serve as a safer alternative.
When asthma is unmanageable with an inhaler, steroid drugs are commonly used, effectively decreasing airway inflammation and alleviating symptoms alongside the risk of asthma attacks. However, these medications can lead to serious side effects. “We aim to minimize the usage of oral steroids,” says Fan Chun from Imperial College London, who was not part of the research.
Previous studies demonstrated that tezepelumab, a monthly antibody injection, reduces the symptoms of severe asthma more effectively than a placebo. This has led to its approval in several countries, including the UK and the US, over recent years. However, it remained uncertain whether this treatment could lessen or eliminate the reliance on steroid drugs.
To investigate this, David Jackson and his colleagues at Guy’s and St Thomas’ Hospital in London recruited 298 individuals aged 18 to 80 with severe asthma from 11 countries. Participants were already using daily inhalers and steroids and were asked to take tezepelumab for one year. Chung noted that a control group wasn’t necessary since prior trials established that the injection had a significant effect compared to a placebo.
Researchers observed that, under medical supervision, participants’ oral steroid doses gradually decreased throughout the study.
By the end of the year, around half of the participants no longer required steroid medication, while 40% were able to reduce their doses enough to “minimize side effects,” according to Chung. “This outcome is highly successful,” he stated. “The trial confirms that tezepelumab is an effective treatment for patients with severe asthma, decreasing the need for daily medications.”
Side effects, such as worsening asthma symptoms, were reported by 9% of participants. However, it is unclear if these were due to the injection or existed beforehand, Chong explained. Nonetheless, he considers the rate acceptable given the advantages of reducing steroid use.
The oral microbiome extracted from King Richard III, derived from analysis of his dental plaque, indicates he may have suffered from a condition that could lead to jaw deterioration.
In 2012, the skeletal remains of Richard III were found beneath a parking lot at the former Greyfriars Church in Leicester, England. Initially thought to be Richard III—who was killed in the Battle of Bosworth Field in 1485 and interred in Leicester—dental and skeletal evidence, including a head wound and spinal curvature, correlated with descriptions from his death. Subsequent genetic tests confirmed the identity of the remains.
Although Richard’s reign only lasted two years amid the Wars of the Roses, he significantly impacted English history, with allegations of plotting against his nephews while they were imprisoned in the Tower of London, alongside William Shakespeare’s portrayal of him as a malevolent figure in his famous play.
Nevertheless, details of Richard’s daily existence are scarce. To uncover more, Turi King and fellow researchers at the University of Bath, UK, collected samples of tartar—hardened dental plaque—from three of his well-preserved teeth.
Dental plaque is effectively a time capsule, retaining DNA from microorganisms and remnants of food. “The quantity of DNA obtained from Richard III’s tartar is among the highest recorded in archaeological contexts,” the researchers stated, noting the detection of over 400 million DNA sequences.
“No one has previously sequenced 400 million ancient DNA fragments; it’s an astonishing figure,” remarks Laura Weyrich from Pennsylvania State University. “This indicates that our capabilities with ancient DNA are likely more extensive than previously thought.”
Dr. King and his team identified almost 400 microbial species from the DNA, comparable in variety to samples from well-preserved dental tartar across Britain, Ireland, Germany, and the Netherlands over the last 7,000 years, spanning from the Neolithic to modern times. “It suggests that elite populations shared microbial strains akin to those of the broader populace, despite their affluent lifestyles and experiences,” Weyrich notes.
However, the research team could not collect adequate plant or animal DNA to determine Richard’s dietary habits. Nevertheless, previous studies on his bones from his last two years indicated he drank non-local wine and consumed large quantities of game, fish, and birds, including swans and herons.
Professor Weyrich indicated that results regarding the microbiome could vary if the team obtained samples from more than one tooth and compared them to similar teeth from groups in Germany or the Netherlands. She also mentioned that their limited sampling does not provide a comprehensive view of Richard’s oral microbiome, as distinct bacteria inhabit different areas of the mouth and different surfaces of the teeth.
The king’s well-preserved teeth may provide insights into his oral microbiome.
Carl Vivian/University of Leicester
One particularly prevalent bacterium identified is Tannerella forsythia, which is linked to periodontal disease, a serious gum infection that can lead to bone loss around the teeth. Given the poor oral hygiene of the 15th century, Richard had a cavity when he died at age 32, though this does not automatically indicate he had periodontal disease.
“Many individuals may harbor potentially harmful bacteria without becoming ill, while others could become infected,” explains Pierre Stollforth from the Leibniz Institute for Natural Products Research and Infection Biology in Germany. Weyrich adds that examining bone loss in the jaw could reveal if Richard suffered from periodontal disease.
“I’m particularly passionate about bridging social science, history, and genetics,” Stallforth states. “Having access to the dental tartar of historical figures is extraordinary as it enables us to gain deeper insights into their lives.”
Rivers across the United States are experiencing increasing temperatures.
A recent analysis of nearly 1,500 river locations spanning over 40 years reveals a rise in the frequency, intensity, and duration of heat waves, posing risks to many species accustomed to cooler waters.
“The increase in river heat waves is actually outpacing that of air heat waves, which is quite surprising,” states Li Li, a professor of environmental engineering at Pennsylvania State University and the study’s author.
A new analysis published in the peer-reviewed journal Proceedings of the National Academy of Sciences is the first comprehensive study defining river heat waves as five consecutive hot days compared to seasonal averages.
The researchers identified climate change, which significantly impacts humans, as a major contributor to this trend, due to diminishing snowpacks and slower stream flows.
Human factors also play a role; for example, dams inhibit downstream flow, while urban structures absorb heat, warming both air and water.
Scientists are concerned that species reliant on cold water, such as salmon and trout, will increasingly struggle as river temperatures rise. Li emphasizes the necessity of tracking fish fatalities and ongoing trends.
Higher temperatures decrease the amount of dissolved oxygen in water. Additionally, cold water species generally exhibit increased metabolism in warmer conditions, leading to further oxygen depletion.
These findings could influence basin management strategies and help determine if adjustments in irrigation or dam releases can support aquatic life during elevated temperatures.
“Water management practices can significantly impact heat waves,” noted Jonathan Walter, a research scientist at UC Davis’ Center for Watershed Sciences, who was not part of the study. “If there is sufficient reservoir water, it may be feasible to moderate downstream temperatures by releasing water to mitigate extreme heat.”
While heat waves in oceans and lakes have been studied extensively, there has been limited research on the implications of rising temperatures in rivers until now.
Satellite data have advanced the study of ocean and lake heat, but river temperature research is challenged by reliance on often unusable river gauge sensors, resulting in significant data gaps.
For this new study, researchers analyzed data from 1,471 US Geological Survey monitoring sites from 1980 to 2022.
This data enabled an assessment of shifts in streams nationwide, revealing that by 2022, river heat waves were occurring more frequently than in 1980, with an average increase of 1.8 additional heatwave events per year. These heat waves were also more severe, with temperatures during these events being approximately 0.8 degrees Fahrenheit higher in 2022 than in 1980. Moreover, the duration of heat wave events extended by over three days.
Li noted that this extra heat caused an average of about 12 days of heat stress for cold water species. The study defined 59°F as the threshold for heat stress, as many species, including bull trout, face survival challenges at this temperature.
“When considering water, its visibility draws attention to its significance,” Li remarked. “We hope this research raises public awareness on water quality challenges stemming from climate change.”
Illegal deforestation in the Amazon of Mato Grosso, Brazil
Paralaxis/Alamy
Life in the Amazon post-deforestation presents a grim scenario. Strong winds impede the recovery of the forest, while rising temperatures result in heat stress for both inhabitants and wildlife.
This contradicts the common belief that rainforest removal leads to a drier local climate.
Many studies suggest that deforestation in the Amazon will significantly reduce rainfall, but these studies often rely on low-resolution models that fail to accurately depict convection patterns in the region.
Recently, Alim Yun from the Max Planck Institute for Meteorology in Germany and her team have employed advanced climate models to represent rainforest rainfall dynamics and convection more accurately.
Dominic Spracklen, at the University of Leeds in the UK, which was not involved in the study, regards this methodology as “highly commendable,” suggesting it could “enhance predictions of climate responses to deforestation.”
Using this innovative approach, Yoon previously reported that under current climatic conditions, a complete deforestation of the Amazon would yield relatively stable average annual rainfall. The ongoing research aims to analyze how hourly patterns of rain, heat, and wind shift in this complete deforestation scenario.
The team’s findings indicate an increase in the frequency of dry spells, with a 54% rise in severe rainfall events. Concurrently, daily temperature extremes rise by 2.7°C (4.9°F) and 5.4°C (9.7°F), significantly heightening heat stress among local populations. Moreover, extremely strong winds are becoming more prevalent.
Over 30 million individuals reside in the Amazon region, including around 2.7 million indigenous people. “Expect intensified rainfall and extreme temperatures,” warns Lewis Catterrand from the University of Leeds. “This is alarming for everyone in the area.”
However, he cautions that further validation of this modeling approach is necessary. Additional research is essential to explore the effects of partial deforestation on the local climate in light of future projections for the region. “These extreme scenarios are meant to aid scientists in understanding the implications, but we know they don’t paint a complete picture,” says Catterrand.
During a year of driving his daughter to school in a new electric vehicle, Phil Bellamy realized that she was anxious about taking a 10-minute ride every day.
While Bellamy, 51, had no issues with the car, his teenage daughter experienced nausea each time she got in. Research indicates that this is a common problem: many individuals who do not suffer from motion sickness in traditional vehicles find themselves affected by it in electric vehicles (EVs).
Concerned about his family’s aversion to riding in his car, Bellamy altered his driving style and considered purchasing a different vehicle, but the issue persisted. His daughters try to avoid traveling with him whenever they can.
“If we go on a trip, they make sure to take motion sickness tablets immediately. They wouldn’t even think of getting in the car without them,” he explains.
Bellamy appreciates driving electric cars for their quietness and smoothness compared to traditional combustion engine vehicles, though he hopes manufacturers will address the concerns of passengers affected by motion sickness.
Factors contributing to motion sickness include the relatively rapid acceleration of EVs compared to gasoline vehicles, the regenerative braking system, and the absence of sensory cues such as engine noise and vibrations while driving.
Research from China, a major electric vehicle producer, has found that EVs tend to induce more severe motion sickness symptoms than traditional vehicles.
Content creator Atia Chain from London shared her experiences on TikTok about suffering from car sickness in an EV this summer when she relied on Ubers for transportation.
Chain reports feeling “extreme nausea” shortly after getting in the EV, which ceased soon after she exited. It took her some time to realize that this happened only in electric vehicles. Now, she tends to avoid Ubers due to the prevalence of EVs.
“Usually, the nausea started right away as soon as the trip began. The first minute was particularly bad. I would roll down the window and find something to distract myself,” she shares. “The sickness lingered throughout the journey. If the Uber ride was 20 minutes long, I’d count down the minutes until I could get out.”
John Golding, a professor of applied psychology at Westminster University in London, explains that motion sickness has a particularly strong effect on passengers because it relates to their ability to anticipate changes in movement.
While the driver controls the vehicle, passengers, especially those seated in the back, may feel helpless. This could pose challenges for the future of self-driving cars.
He suggests that individuals may also use motion sickness medication or adopt behavioral changes to cope. “The simplest solution is to sit in the front seat and have a clear view. It allows you to see and anticipate what will happen next, whereas sitting in the back means you can only see what has already happened,” he advises.
Consider motion sickness medication which can be obtained in patches or tablets from pharmacies, helping manage how your brain and body react to movement. It’s most effective when taken before travel.
Wear acupressure bands which some studies suggest may help, though results could primarily be attributed to the placebo effect. “If it works for you, don’t dismiss it,” Golding remarks.
Listen to low-frequency sounds. A study from Nagoya University in Japan indicates that certain vibrations at 100Hz may stimulate a part of the inner ear responsible for detecting gravity and acceleration.
This weekend, powerful and destructive thunderstorms are anticipated in the Midwest, Central Plains, and Southeast, leading to heavy rain and flash flooding in the upcoming days.
By early Saturday, rain and strong wind gusts had already left over 50,000 residents in Nebraska without power. Poweroutage.us. The National Weather Service warns that severe weather may still be unfolding.
The agency forecasts “massive nocturnal thunderstorms” affecting parts of the Midwest from the weekend through Monday.
Clusters of thunderstorms, especially during nighttime, are likely to produce “very heavy rain” along corridors extending from northern Missouri to southern Iowa and southern Wisconsin. The National Weather Service reports.
Consequently, there is a significant flash flood threat across the region.
In the Southeast, storms are expected to persist, particularly in northern Florida and southern Georgia this weekend, accompanied by heavy rainfall.
“The daily heavy rains on already saturated ground present localized flooding risks, especially along the coast in southeastern Georgia,” the local NWS branch in Jacksonville, Florida, stated in their weekend predictions.
Central and South Florida may experience numerous showers and slow-moving storms, leading to damaging winds and heavy downpours, according to the NWS.
Meanwhile, the Southwest is grappling with record-breaking heat. Triple-digit temperatures are widespread in Arizona, Nevada, and New Mexico, with Phoenix hitting 118 degrees Fahrenheit on Thursday, breaking the city’s daily record. Other Arizona cities, including Scottsdale, Yuma, Bryce, and Deer Valley, have also reported similar daily temperature records. The National Weather Service confirmed.
Although the weekend temperatures in Arizona and other areas of the Southwest Desert are expected to be less extreme than recent highs, the NWS indicates that high temperatures above 110 degrees Fahrenheit are still possible.
In Albuquerque, Friday’s high of 101 degrees Fahrenheit shattered the previous record of 98 degrees F set in 2011. The NWS reported. A heat advisory remains in effect until Saturday evening, just before a storm moves through central and northeastern New Mexico on Sunday.
A report published on Tuesday by German multinationals revealed that weather-related disasters in the first half of this year caused $93 billion in damages within the United States.insurancecompany.
An analysis from Munich RE, the largest reinsurer in the world, indicated that over 70% of the global damages from this year’s weather disasters occurred in the United States, leading to a burden of $22 billion on uninsured Americans and their local governments.
The report underscores the increasing economic impact of wildfires, severe storms, and other extreme weather events both in the US and globally. It also highlights the escalating insurance crisis in nations frequently afflicted by such disasters.
“Approximately 90% of all industry losses were observed, with $72 billion out of $80 billion occurring in the US,” stated Tobias Grimm, chief climate scientist at Munich RE. “That is remarkable.”
The catastrophic wildfires in Southern California in January ranked as the most expensive disaster in the country during the first half of 2025. The two major fires, responsible for at least 30 fatalities and displacing thousands, swept through the Pacific Ocean’s Pallisad and Altadena neighborhoods.
Munich RE estimated the wildfire losses at $53 billion, including costs affecting uninsured residents. The reinsurer noted that these flames in the Los Angeles area resulted in “the highest wildfire loss ever recorded.”
The significant economic and social impacts of wildfires can be partly attributed to the increasing development in fire-prone areas.
“In many instances, losses are growing due to property developments causing damage,” Grimm explained. “People continue to reside in high-risk zones.”
Urbanization in disaster-prone areas can similarly escalate the costs associated with other weather-related events, like hurricanes and floods, which are becoming more frequent and severe due to climate change.
Research indicates that climate change is becoming increasingly frequent as temperatures rise and drought conditions worsen. Consequently, the intensity of wildfires is also increasing.
A report by the World Weather Attributes Group issued in late January found that high temperatures, along with dry and windy conditions conducive to fire spread in Southern California, could be approximately 35% more likely due to human-induced global warming.
Melanoma is a form of skin cancer that can metastasize
Science Photo Library
After years of research and extensive human trials, only one virus specifically engineered to target cancer has gained approval from US and European regulators. Following promising results in treating melanoma—a notably aggressive skin cancer—approval may soon be granted.
The genetically altered herpes virus, known as RP1, was injected into the tumors of 140 patients with advanced melanoma who did not respond to conventional treatments. All participants also received a medication called nivolumab, designed to enhance the immune response against the tumors.
In 30% of the treated individuals, tumors shrank, including those that were not directly injected. Notably, in half of these cases, the tumors were completely eradicated.
“Half of the patients who responded experienced a complete response, meaning total disappearance of all tumors,” said Gino Kim from the University of Southern California. “I am thrilled with these results,” he added, noting that other treatments for patients at this stage often perform poorly and have harsher side effects.
A larger trial involving 400 participants is currently in progress; however, RP1 may receive approval from the US Food and Drug Administration (FDA) to be used in conjunction with Nivolumab for treating advanced melanoma before the trial concludes. The New Scientist reports that “the FDA is anticipated to make a decision by the end of this month.”
For over a century, it has been recognized that viral infections can aid in cancer treatment, though intentionally infecting someone with a “wild” virus poses significant risks. In the 1990s, scientists attempted to genetically modify viruses to effectively target cancer while leaving healthy cells unharmed.
These engineered viruses function in two main ways: First, they directly invade cancer cells, causing them to rupture and die. Secondly, they stimulate immune responses aimed at all cancer cells present in the body.
For instance, T-VEC, a modified herpes simplex virus, was engineered to release an immune-boosting factor called GM-CSF within infected tumor cells. T-VEC received approval in 2015 in both the US and Europe for treating inoperable melanoma.
Unfortunately, T-VEC’s use is limited as it was only tested and approved for injection into skin tumors. Many patients with advanced melanoma have deeper tumor locations, as noted.
With RP1, the strategy shifted to administering it into deeper tumors. RP1, like T-VEC, is a herpes simplex virus but has undergone various enhancements. It notably aids in fusing tumor cells with adjacent ones, thus boosting viral spread within the tumor and reinforcing the immune response.
Though there have been no direct comparisons between T-VEC and RP1, RP1 demonstrates a greater likelihood of reducing all tumors, rather than just those directly injected. “It indicates a more pronounced systemic effect,” experts state.
Thus, should RP1 gain approval, its application is expected to be far broader than that of T-VEC. Experts believe this could significantly enhance the overall interest in utilizing cancer-targeting viruses. “There seems to be increasing enthusiasm for this approach.”
A team of paleontologists from the University of Zurich has identified chronic instances of osteomyelitis (bone tissue infection) in Plateosaurus trossingensis, one of the well-known dinosaurs from the late Triassic period in Europe.
Diagram of Plateosaurus trossingensis skeletons featured in the Theoprati exhibition at the Museum of Natural History, University of Zurich. Image credits: Dupuy et al., doi: 10.1186/s13358-025-00368-3.
Plateosaurus trossingensis inhabited Europe around 220 million years ago during the late Triassic epoch.
These ancient creatures were approximately 8 m (26 feet) long and primarily walked on their hind legs.
In a recent study, paleontologist Jordan Bestwick and colleagues analyzed the skeleton of Plateosaurus trossingensis from the Klettgau Layer in Switzerland.
They discovered significant osteomyelitis in the dinosaur’s upper arm and right shoulder.
“Osteomyelitis affects various living animals, including humans, birds, and reptiles,” noted Dr. Bestwick.
“The condition has been documented in several dinosaur groups, including sauropods, leading us to assess and compare numerous specimens, including Plateosaurus.
“The impacted bones in the shoulders and upper arms displayed notably rough internal and external textures, altered shapes, and even fusion, which are broad indicators of osteomyelitis.”
Researchers find their discoveries particularly intriguing since this case represents the oldest recorded instance of osteomyelitis in dinosaurs, dating back to about 220 million years ago, and the extent of the infection was unusually large.
“Earlier studies highlighted localized infections, such as in toe bones or adjacent vertebrae,” Dr. Bestwick explained.
“It’s exceptionally rare to observe infections in a shoulder and the entirety of an upper arm.”
“While the initial cause of the infection remains unknown, it likely plagued the animal for a prolonged period, potentially rendering its right arm nonfunctional.”
These findings are detailed in a paper published in the Swiss Journal of Palaeontology.
____
sfj dupuis et al. 2025. Osteology and histology of a Plateosaurus trossingensis (Dinosaur: Sauropodomorpha) from the Upper Triassic in Switzerland with advanced chronic pathology. Swiss J Palaeontol 144, 27; doi:10.1186/s13358-025-00368-3
IT is a warehouse resembling the size of 12 football pitches, poised to provide essential employment and development opportunities in the city of Caucaia, northeastern Brazil. Yet, the shelves remain empty. This extensive facility is set to transform into a data center, as designated by TikTok, になったんです。 English: The first thing you can do is to find the best one to do. part of a 5.5 billion Reais (7.3 billion pounds) project aimed at expanding the global data center infrastructure.
With the increasing demand for supercomputer facilities, Brazil is attracting an array of high-tech companies, buoyed by the AI boom. The selection of Caucaia is strategic. Submarine cables carry data from Fortaleza, the nearby capital of Ceará, to various continents. Proximity to these cables enhances traffic capacity and reduces latency—the response time across the Internet network.
Additionally, Caucaia is home to the Pecém EPZ, where businesses can produce goods and services for export, benefiting from various tax incentives and streamlined bureaucratic processes.
However, data from Brazil’s disaster digital atlas and integrated disaster information system indicate that Caucaia is also prone to extreme weather events, including drought and heavy rainfall.
Between 2003 and 2024, the city experienced drought-related emergency conditions declared at least once. In 2019, around 10,000 residents were impacted by water shortages. The digital atlas of disasters shows that as reservoirs depleted, water quality diminished, leading to crop failures and challenges in access to basic food supplies.
Data centers consume vast amounts of energy and water to keep supercomputers cool. Nevertheless, public agencies are promoting green construction in drought-affected areas. Caucaia is part of a broader trend.
According to the Digital Disaster Atlas, five of the 22 planned data centers are situated in cities that have faced repeated drought and water scarcity since 2003.
So far, China’s social networks have not been mentioned in Caucaia’s permit application. However, in February, the chief of staff for the state government, Chagas Vieira, confirmed in an interview with local radio stations that discussions were ongoing with Chinese firms, and representatives from TikTok and its parent company ByteDance met with senior officials, including the Vice President and Minister of Development, Industry, Trade, and Services, Geraldo Alckmin.
ByteDance has been approached for comments.
The truck will deliver water to Caucaia, a city facing repeated problems with drinking water supply. Photo: Marília Camelo/The Guardian
The project is officially led by Casa dos Ventos, a Brazilian wind energy firm that has invested in the data center sector. Mario Araripe, the company’s founder and president, announced last year that he aims to attract major global technology companies like Apple, Amazon, Google, Meta, and Microsoft to fill the facility with computers.
Casa dos Ventos has already secured one of the three required licenses from the state of Ceará. According to the state’s Environmental Supervision (SEMACE), the project received a license for “30m³/day water consumption in closed circuits supplied by Artesian Well.” Specific details have been withheld for commercial confidentiality.
Casa dos Ventos claims it is “committed to transforming Porto do Pecém into a complex of technological innovation and energy transition.”
Projects requiring significant energy, such as data centers, are required to obtain special permission from the Brazilian government. As of 2024, at least seven of the 21 approvals granted by the Ministry of Mines and the Ministry of Energy were linked to data centers.
Casa dos Ventos is also responsible for another data center project currently under state review in Campo Redondo, Rio Grande do Norte, a region that has experienced drought for 14 out of the last 21 years. During the water crisis in 2022, local governments sought federal aid, and water trucks were dispatched to address the demand.
A similar situation is unfolding in Igaporanga, Bahia, where a Brazilian renewable energy company plans to establish two data centers. The city has been in a state of emergency due to drought conditions for 12 of the years between 2003 and 2022. In 2021, about 5,500 people faced rural water shortages.
Transparency regarding water usage by data centers under construction in these areas is lacking. Companies have not disclosed this information voluntarily, and the government has withheld technical documents for licensing, citing commercial confidentiality.
In early April, the National Electric Power System Operator (ONS) denied requests for access to the grid for Casa dos Ventos, citing concerns for grid stability. Consequently, the Ministry of Mines and Energy requested a recalculation to assess potential grid adjustments.
bIG tech firms acknowledge their water consumption in water-scarce areas heightened by AI requirements. The 2024 Sustainability Report details that Microsoft reported that 42% of its water usage originates in regions experiencing water stress. Similarly, Google stated that in the same year, 15% of its water consumption fell in areas marked by “high water scarcity.”
Data centers utilize a large volume of water to prevent overheating in computers and machines. However, some water may evaporate, potentially exacerbating the local climate crisis where they are located. As AI technologies evolve, the demand for processing power increases, leading to heightened energy and cooling requirements. Consequently, water and energy consumption are projected to rise.
Workers at a Data Center in Porto Alegre, Rio Grande do Sul, Brazil. Such facilities utilize considerable amounts of water for cooling machinery. Photo: Jeff Botega
The International Energy Agency projects a significant increase in data center energy consumption to double, reaching 945,000 GWh by 2030—equivalent to Japan’s annual energy consumption. Countries like Brazil will account for approximately 5% of this growth within that timeframe.
Water consumption is expected to surge. Researchers from the University of California, Riverside, and the University of Texas at Arlington estimate that global AI demand will require between 4.2 billion and 6.6 billion cubic meters of water by 2027, surpassing half of the UK’s annual water usage.
However, Shaolei Ren, a researcher from UC Riverside and co-author of the study, highlights a crucial distinction between consumption (water extracted from the system) and loss (water evaporated).
“Residential users generally do not withdraw significant amounts of water, but data centers often consume between 60% and 80%,” notes Ren, meaning that much water is lost.
Data centers can be cooled through two approaches: one is air conditioning, a widely adopted method for various facilities, while the second is utilizing water.
The outskirts of Caucaia, where inadequate water became unsuitable for urban consumption after reservoirs were depleted in 2019. Photo: Marília Camelo/The Guardian
One method involves recycling or reusing water but incorporates fans and radiators within closed systems, resembling car engine technologies. Alternatively, a cooling tower might use evaporation to expel heat from heated water, allowing the return of cold water to the system. The final method involves misting water into the air, increasing humidity and reducing temperature.
Nonetheless, these methods are not without inefficiencies. “Both evaporation and misting lead to water loss,” asserts Emilio Franceschini, an associate professor at ABC Federal University.
A small data center with a capacity of 1MW consumes around 25.5 million liters of water annually, with an estimated 1% (255,000 liters) lost to evaporation.
In Pecém, alternatives to extracting water include purchasing desalinated seawater or recycled water from Fortaleza.
It falls upon the state government to grant water concessions to data centers as part of the environmental licensing process.
rOnildo Mastroianni, technical director at Esplar, an NGO with a 50-year presence in Ceará, argues that projects demanding high water consumption in semi-arid areas are misguided. “It’s simply pushing for increased dryness,” he asserts.
Mastroianni cautions that such projects could alter the local hydrological basin, which may weaken fragile ecosystems, like the Caatinga, and heighten food insecurity due to rural water scarcity. He indicates that representatives from local NGOs and various Kilombola and Indigenous communities were not included in project discussions.
Due to water stress, many communities have constructed reservoirs to secure water supply during drought periods. Photo: Marília Camelo/The Guardian
Other Latin American nations are also witnessing a surge in the data center industry. Chile has launched 22 data centers in the Santiago region alone. In December, the government announced a National Plan to establish 30 additional projects, projected to place the country at medium to high levels of water stress by 2040, signifying decreased water availability.
In Chile, both governmental and corporate bodies are facing escalating opposition. In 2019, Google disclosed plans for its second data center in Santiago, which sparked estimates from the activist organization MOSACAT indicating the project would extract 700 million liters of water annually.
Following a wave of protests, a Santiago court reviewed the project. By early 2024, the court halted Google’s assessments concerning environmental impacts, pending further evaluation.
Among those advocating against the project was Tania Rodriguez of MOSACAT, who lamented, “That turned into extractivism,” she said in interviews with other outlets. “We will become everyone’s backyards.”
Drought conditions can have severe repercussions in regions like Karapinar in Türkiye
Yasin Akgul/AFP via Getty Images
Over the past two decades, from the grain stores of Ukraine to towns in northern China, Eurasia has experienced a notable increase in droughts following extreme heat events. Tree ring analysis extending back nearly three centuries indicates that human-induced climate change is a significant factor in the acceleration of these combined catastrophes.
This phenomenon presents a severe threat due to the way heat and drought reinforce each other. Elevated temperatures deplete soil moisture, and droughts further reduce the humidity needed to mitigate the impact of subsequent heat waves. This harmful cycle contributes to decreased agricultural productivity and a heightened risk of wildfires.
Certain regions in Eurasia have encountered similar heat and drought patterns in the past, but researchers assert, “current developments exceed natural fluctuations,” according to Hans Linderholm, a researcher at the University of Gothenburg, Sweden.
The complete landscape became apparent only after Linderholm and his team compiled tree ring data covering Eurasia from 1741, which reflects temperature and precipitation variations. This allowed them to recreate a comprehensive distribution of high- and low-pressure systems that influence wet and dry conditions across the continent.
Researchers identified specific phenomena affecting the area, termed the “heatwave motion train of iolarism,” which has intensified since 2000, amplifying anomalies beyond historical measurements. This alteration is associated with atmospheric pressure changes prompted by warming in the North Atlantic and increased precipitation in some regions of North Africa, both linked to anthropogenic climate change.
Rising local temperatures can directly worsen extreme heat and drought situations. However, new research indicates that climate change is modifying the dynamics between distant atmospheric regions (referred to as teleconnections), further complicating the situation, Linderholm explains.
Climate model forecasts predict worsening conditions under all scenarios except for those with the lowest emissions. “We observe a distinct, robust trend in this new teleconnection pattern, suggesting that impacts will escalate in both speed and severity,” states Linderholm.
“It is difficult to envision how [the most affected regions will] recover,” he concludes.
This month, Health and Human Services Secretary Robert F. Kennedy Jr. shared the government’s latest findings on autism, presenting a stark and controversial viewpoint.
The notion that severe autism symptoms are on the rise lacks scientific backing. In fact, a recent study presented at the International Association for Research on Autism in Seattle indicates that the percentage of autism cases characterized by moderate to severe symptoms remained relatively stable from 2000 to 2016.
In recent weeks, Kennedy has consistently described autism as an “explosion,” attributing it to an increase in serious cases of intellectual disability.
“This trend is unprecedented. It raises alarms about community dynamics,” he told Fox News earlier this month. “This is effectively invalidating these children for their entire lives.”
Kennedy’s claims have drawn criticism from parents, advocates, and health professionals who argue that he represents a limited data set to generalize the autism spectrum.
According to a recent report by the Centers for Disease Control and Prevention, one in 31 children receives an autism diagnosis by age eight, though it did not distinguish between mild and severe cases.
During the briefing on April 16, Kennedy estimated that a quarter of diagnosed children were non-verbal or required assistance with toileting. A previous CDC study indicated that nearly 27% of individuals with autism are non-verbal or have an IQ below 50. Many researchers, however, suggest that the actual rates may be lower.
Autism is a spectrum disorder, meaning it encompasses a range of symptoms, from mild to more pronounced, influencing how individuals socialize, communicate, learn, and behave.
A new study released this week highlighted that only mild cases increased between 2000 and 2016.
This study analyzed data from the CDC’s Autism and Developmental Disorder Surveillance Network, tracking autism cases across the United States. The researchers assessed adaptive test scores (evaluating children’s social, communication, and daily living skills) in contrast to IQ scores that indicate intellectual disability to determine case severity.
Co-author Maureen Durkin, a professor of population health sciences at Wisconsin-Madison, stated:
David Mandel, a professor of psychiatry at the University of Pennsylvania, noted that he wasn’t involved in the analysis but remarked that adaptive scores were intended to capture severe cases like those described by Kennedy. Compared to IQ scores, adaptive scores better reflect how children with autism function in real life, including their ability to interact with others, manage self-care, and use the toilet independently.
The analysis indicated that in 2016, 1.2 out of every 1,000 children were diagnosed with moderate to severe autism, while mild cases surged by 139% in the same period, from 1.5 out of 1,000 in 2000.
“The rise is primarily among children without severe disabilities, and it would be beneficial for the current HHS secretary to be aware of that,” said Marianne Burton, a clinical professor of psychological science at the University of Connecticut.
The Department of Health and Human Services did not respond to requests for comment.
One potential reason for the increase in mild cases is improved identification by healthcare professionals. Developmental screening became increasingly common during the study period, and in 2006, the American Academy of Pediatrics began recommending universal autism screenings.
Additionally, the diagnostic criteria for autism were revised in 2013 to include mild cases, such as those previously classified as Asperger’s syndrome.
“We’re witnessing a significant expansion of diagnostic criteria that now encompasses individuals who wouldn’t have qualified for an autism diagnosis 50 years ago,” Mandel explained.
Dr. Alex Collebzon, clinical director of the Seaver Autism Center at Icahn School of Medicine at Mount Sinai, mentioned the analysis relied on health and educational records, potentially including children with mild symptoms who may not have undergone direct diagnostic assessments.
“Assessing this cohort, I believe they are likely quite confident in their diagnosis, but we are not observing an increase in prevalence,” he stated.
Kennedy rejects the notion that the rise is due to improved diagnostic practices, suggesting that only a “small fraction” of the increase in cases can be attributed to this.
“The media has perpetuated myths in this industry, promoting the idea that autism is more prevalent simply because we are identifying more cases,” he told Fox News host Sean Hannity this month.
Instead, Kennedy unfoundedly claims that environmental toxins are the primary drivers behind increasing cases and has tasked CDC scientists with identifying the source by September.
Kolevzon acknowledged that environmental factors could exacerbate underlying genetic risks for autism, but existing research has yet to pinpoint any specific causative agents.
“We are unlikely to uncover widespread environmental factors that would fully explain the rising prevalence,” he concluded.
As an earthquake ruptures along the Cascadia subduction zone fault, much of the US West Coast will experience intense shaking for five minutes, with tsunamis potentially generating waves up to 100 feet crashing towards the shore. However, this is only the onset of anticipated devastation.
Even if coastal communities in Northern California, Oregon, and Washington withstand the initial earthquake, recent research indicates that flooding could inundate many of these susceptible regions. This is due to an expected drop of 6½ feet in the entire coastal land when the earthquake strikes, according to a new study published Monday in the Proceedings of the National Academy of Sciences (PNA).
Researchers examined earthquake and flood models to provide some of the most comprehensive predictions about how Cascadia earthquakes can lower or subside coastal land, potentially affecting over twice as many people, structures, and roadways as currently established. The exacerbating effects of climate change are projected to raise sea levels, compounding the issue over time.
“The repercussions of these hazards will linger for decades or even centuries following the earthquake,” stated Tina Dura, the study’s lead author. “Tsunamis will strike and have a considerable impact. Don’t misunderstand me; however, a lasting change in flood frequency… that is a critical concern.”
The team will operate the Vibracore Rig in Silets Bay, Oregon, collecting deep sediment cores in 2022 for tsunami deposits and paleoseismic analysis. Tina Dura
Dura explained that geological fossil evidence suggests that previous Cascadia earthquakes resulted in a significant drop in land level, transforming once dry areas into tidal mud flats along the Pacific Northwest’s estuaries.
An assistant professor of geoscience at Virginia Tech, Dura noted: “This is how we have a harbor…and where we’ve established towns, yet that land will plummet by a maximum of two meters.”
The Cascadia subduction zone fault offshore of North America presents an imminent threat, capable of generating magnitude 9.0 earthquakes. Such events are expected to occur on average every 450-500 years, with the last major quake dating back to 1700.
The national seismic hazard model indicates a 15% chance of an earthquake measuring 8.0 or higher occurring along the zone within the next 50 years.
When the fault ruptures, experts assert that it could lead to the most catastrophic natural disaster in the nation’s history. Simulations from 2022 predict that the Cascadia earthquake could damage around 620,000 buildings in the Pacific Northwest, including 100 hospitals and 2,000 schools, resulting in over 100,000 injuries and approximately 14,000 fatalities.
Recent findings emphasize that coastal planners must seriously consider not only the immediate threats of strong shaking and tsunami waves but also the long-term impacts of land reshaping and rapid subsidence of the coastline itself.
“There will be the flooding itself, as well as enduring changes in land elevation along the coast, greatly affecting community planning,” remarked Harold Tobin, director of the Pacific Coast Earthquake Network and professor at the University of Washington. “Where will schools and hospitals be built? Where will transportation networks be established? A long-term perspective is vital.”
Following the earthquake, Dura’s research predicts that towns along the Pacific Northwest coastline, such as Seaside, Oregon, Westport, Washington, and Aberdeen, Washington, will likely experience frequent flooding, at least once every century.
The study also highlights that climate change-induced sea level rise will accelerate, aggravating the consequences of post-earthquake flooding in the future.
A field team across the mouth of the Salmon River in Oregon will transport coring and surveying equipment to the next sampling site in 2023. Mike Pridy
Global average sea levels have risen by approximately 8-9 inches since 1880, according to the National Oceanic and Atmospheric Administration (NOAA). Dramatic acceleration in sea level rise is anticipated in the coming decades due to global warming, with NOAA estimating an increase of 10-12 inches.
The impact of sea level rise varies depending on location and can significantly affect the coastline.
In places like Chesapeake Bay, Virginia, land is gradually sinking, a process termed subsidence, while portions of the Pacific Northwest are experiencing uplift due to continental movements. This uplift can offset some of the sea level rise.
The uplift is attributed to the stress build-up within the plates forming the Cascadia subduction zone. In this zone, the Juan de Fuca plate is forced beneath the North American plates, causing a slight upward movement of land.
Currently, the subduction zone faults remain inactive, accumulating stress. When the fault eventually ruptures, the released plate bow leads to rapid land-level subsidence, effectively negating the uplift for centuries.
“It all transpires in a matter of minutes, resulting in meter-level drops,” stated Dura. “The land continues to shift, and as I mentioned, this has ramifications that will last for decades and centuries. Consequently, the critical areas of the floodplain are significantly impacted.”
The harmful bleaching of corals around the world has increased to affect 84% of the ocean coral reefs, marking the most intense event in recorded history, as announced by the International Coral Reef Initiative on Wednesday.
This is the fourth global bleaching event since 1998, surpassing the 2014-17 bleaching that impacted two-thirds of the reefs during that time. The current crisis began in 2023, and it remains unclear when it will end, with ocean warming being criticized for the phenomenon.
Mark Eakin, the executive director of the International Coral Reef Association and former coral monitoring officer for the US National Marine and Atmospheric Administration, stated, “We’re witnessing a complete transformation of the planet and its impact on our oceans’ ability to sustain life and livelihoods.”
Last year was reported as the hottest year on record globally, with average sea surface temperatures for oceans away from the poles reaching 20.87 degrees Celsius (69.57 degrees Fahrenheit), which is detrimental to corals. These structures are vital for seafood production, tourism, and protecting coastlines from erosion and storms. Coral reefs are often referred to as “rainforests of the sea” because they host a significant amount of marine biodiversity, with approximately twenty five% of all marine species living in and around them.
Corals house colorful algae, which give them their vibrant hues and serve as a food source. However, prolonged warming causes the algae to release toxins, leading to coral bleaching where they expel the algae and turn white. Weakened corals are at an increased risk of death due to these events, prompting NOAA’s Coral Reef Watch program to introduce additional levels to the bleaching alert scale to convey the heightened risk of coral mortality.
Efforts to conserve coral reefs are underway, such as initiatives to restore coral populations. Dutch labs are working with coral fragments, including those sourced from the Seychelles, with the intention to propagate them in zoos for potential reintroduction to natural reef habitats. Similar projects, including those in Florida, aim to rescue at-risk corals from high temperatures and rehabilitate them before returning them to the sea.
Nevertheless, scientists stress the importance of reducing greenhouse gas emissions like carbon dioxide and methane to combat planet-warming effects and protect coral reefs.
Melanie Mcfield, co-chair of the Caribbean Steering Committee for the Global Coral Reef Surveillance Network, emphasized, “The most effective way to safeguard coral reefs is to address the root causes of climate change by reducing human emissions, primarily from fossil fuel combustion. Inaction poses a significant threat to coral reef ecosystems.”
This update coincides with President Donald Trump’s efforts to bolster fossil fuels and scale back clean energy initiatives as he enters a second term, prompting concerns about the future of coral reefs. Eakin remarked, “The current government is actively dismantling these ecosystems, and eliminating their protections would have catastrophic consequences.”
Refineries in New Mexico are blaming the federal government for severe air pollution issues.
A chemical plant in Louisiana is under investigation for gas leaks from storage tanks.
An Idaho rancher is accused of polluting wetlands.
Under President Biden, the Environmental Protection Agency took a strong stance on environmental enforcement against pollution and waste violations. On the other hand, the Trump administration aims to shift the EPA’s focus from environmental protection to reducing costs related to transportation, heating, and business operations. The stability of long-term research initiatives is now uncertain due to recent EPA policy changes.
A memo from March 12 states that EPA enforcement actions will not intervene in energy production unless there is an immediate health risk. The memo also undermines President Biden’s efforts to address pollution disparities affecting low-income communities. It emphasizes that no consideration should be given to the affected individuals’ minority or economic status.
EPA Administrator, Lee Zeldin, believes these changes enable agents to focus on their core mission and contribute to a successful American resurgence.
David Ullman, who oversaw enforcement at the EPA during the Biden administration, criticized the recent memo for absolving corporations, especially in the oil and gas industry, of responsibility for breaking the law.
He expressed concern that these changes harm communities across the United States.
EPA spokesperson, Molly Vaseliou, refrained from commenting on ongoing investigations. The Justice Department, facing internal issues and budget cuts, also chose not to comment.
Conservatives argue that EPA regulations hinder economic growth and investment, while supporters believe that deregulation efforts will boost American energy and reduce costs for families.
Despite ongoing enforcement cases initiated by the Biden administration, the direction of the EPA’s objectives is shifting under the Trump administration, including the removal of key environmental regulations.
Woman drinks water during heat waves in French Hierrez
Magali Cohen/Hans Lucas/AFP Getty Images
Extreme fever appears to speed up biological aging in older adults, suggesting that it may increase the risk of age-related diseases.
“This is one of the first large-scale studies linking long-term heat exposure to biological aging in humans,” he says. Eun Young Choi At the University of Southern California. “Elderly people who live in areas with biologically extreme heat in cooler areas.”
Choi and her colleagues analyzed genetic data extracted from blood samples collected by other researchers from 3,600 people in the US in 2006-7. At the time, they were all over 56 years old.
They estimated the biological age of each participant using three so-called epigenetic clocks, including seeing patterns of chemical tags called methyl groups on DNA. These patterns change as we age, and such changes are associated with age-related diseases.
The researchers also looked at daily temperature measurements taken within a few kilometres of where participants lived for six years before blood samples were collected.
They found that every 200 days of six years when participants were exposed to daily maximum temperatures of at least 32.2°C (90°), biological age was on average up to 3.5 months old, and on average up to 3.5 months of age than those in cooler areas. That number depends on which watch was used.
“This refers to heat exposure increasing the rate of biological aging,” he says. Austin Argencheri At Harvard University, where he was not involved in the research.
Previous studies on the Taiwanese and German people have also found a link between extreme heat exposure and biological aging.
However, epigenetic watches do not fully capture the aging process or the risk of people's illnesses, says Argentieri. “More jobs that can link both extreme heat exposure, biological aging from these watches, age-related diseases, mortality and the effects on life expectancy itself will help us drive home what we need to take away from now on.”
Furthermore, the study did not consider access to air conditioners or the duration of time participants spent outdoors, so individual exposure changes to heat exposure, says Argentieri. The team controlled for other factors such as age, gender, race, wealth, ethnicity, smoking status, alcohol consumption, obesity, and physical activity.
Furthermore, research should investigate whether results will be translated to younger people or to people living in different countries where people may have different approaches to keeping people cool, says Argentieri.
Identifying the people who are at the lowest risk of aging fastest due to extreme heat could help policymakers develop and deploy measures to protect them, he says.
Climate change could increase the frequency and severity of droughts
Zhang Yu/VCG via Getty Images
Severe, perennial droughts have become hotter, drier, and more extensive since the 1980s. These prolonged droughts, some of which are so extreme that they are classified as ‘megadroughts’, can have particularly devastating effects on agriculture and ecosystems.
Rising temperatures associated with climate change are increasing the risk of drought by making the air warmer, retaining more moisture, and increasing evaporation from the land. Combined with changes in precipitation patterns that lead to reduced rainfall, this could exacerbate droughts and lengthen their duration. This is evidenced by the recent megadrought in parts of North and South America, the worst in 1,000 years.
dark cargar Researchers from the Swiss Federal Institute for Forestry, Snow and Landscape Research identified more than 13,000 droughts lasting at least two years from 1980 to 2018 to uncover long-term trends. They found that the most severe multi-year droughts since the 1980s have become drier and hotter.
Droughts are also affecting wider areas of the planet, with the area affected by the 500 most severe droughts each year expanding by around 50,000 square kilometers each year. “That’s an area larger than Switzerland,” Karger says.
Satellite images showing green areas in drought-affected areas also show some ecosystems turning brown, indicating that dry conditions are having an effect. The most dramatic changes were seen in temperate grasslands, which are more sensitive to changes in water availability, while tropical and boreal forests showed smaller responses.
The researchers have not conducted a formal analysis to define how much anthropogenic climate change is contributing to this trend, but they say the pattern is consistent with the rise in temperatures researchers expect. states. benjamin cook from Columbia University in New York was not involved in the study.
The study highlights that long-term droughts can have consequences as severe as climate disasters such as devastating wildfires or powerful hurricanes, Cook said. “It’s the cumulative effects of drought, both for humans and ecosystems, that really matter.”
Over 140 Facebook content moderators have been diagnosed with severe post-traumatic stress disorder as a result of being exposed to distressing social media content, including violent acts, suicides, child abuse, and terrorism.
Dr. Ian Kananya revealed that these moderators, based at a facility in Kenya contracted by social media companies, worked long hours and were diagnosed with PTSD, generalized anxiety disorder (GAD), and major depressive disorder (MDD) by the Head of Mental Health Services at Kenyatta National Hospital in Nairobi.
A lawsuit filed against Meta, Facebook’s parent company, and the outsourcing company Samasource Kenya, which employed moderators from across Africa, brought to light the distressing experiences faced by these employees.
Images and videos depicting disturbing content caused some moderators to have physical and emotional reactions such as fainting, vomiting, screaming, and leaving their workstations.
The lawsuit sheds light on the toll that moderating such content takes on individuals in regions where social media usage is on the rise, often in impoverished areas.
Many of the moderators in question turned to substance abuse, experienced relationship breakdowns, and felt disconnected from their families, due to the nature of their work.
Facebook and other tech giants use content moderators to enforce community standards and train AI systems to do the same, outsourcing this work to countries like Kenya.
A medical report submitted to the court depicted a bleak working environment where moderators were constantly exposed to distressing images in a cold, brightly lit setting.
The majority of the affected moderators suffered from PTSD, GAD, or MDD, with severe symptoms affecting a significant portion of them, even after leaving their roles.
MetaSource and Samasource declined to comment on the allegations due to the ongoing litigation.
Foxglove, a nonprofit supporting the lawsuit, highlighted the lifelong impact that this work has had on the mental health of the moderators.
The lawsuit aims to hold the companies accountable for the traumatic experiences endured by the moderators in the course of their duties.
Content moderation tasks, though often overlooked, can have significant long-term effects on the mental health of those involved, as seen in this case.
Meta stresses the importance of supporting its content moderators through counseling, training, on-site support, and access to healthcare, while implementing measures to reduce exposure to graphic material.
Thousands of homes lost power, as downed power lines and trees blocked highways in Washington state on Tuesday due to a powerful atmospheric river event, officials announced.
Forecasters stated that a storm could bring up to 15 inches of rain and heavy snowfall in the mountains. By 7 p.m. local time, about 100,000 homes and businesses in Washington and over 14,000 homes in Oregon were without power, as reported by news agencies on the Rack Website poweroutage.us.
The Bellevue, Washington, fire department warned, “Trees are falling across the city, hitting homes.” They advised residents to stay away from windows and not to go outside if possible. X was contacted on Tuesday around 8pm.
Weather forecasters warned of a whiteout snowstorm in the Cascade Range and possible 2 feet of snow in Mount Shasta, Northern California, along Interstate 5. High wind gusts of up to 90 mph were recorded on Mount Rainier and 52 mph in Seattle-Tacoma International Airport.
Known as bomb cyclones, these intense winds are caused by rapidly intensifying storm systems with decreasing atmospheric pressure. Scientists attribute this phenomenon to climate change generating more atmospheric rivers, which are significant contributors to precipitation on the West Coast.
An atmospheric river storm could bring significant rainfall over a three-day period in Northern California, with a flood watch issued in several areas. These storms help replenish water supplies after dry summers, but can also lead to severe flooding and damage.
Satellite images show a weather system moving towards the Pacific Northwest, prompting concerns of damaging winds, rain, and snow. Climate scientists are closely monitoring the storm and its potential impacts on various regions.
Satellite images show the weather system moving closer to the Pacific Northwest on Tuesday morning. NOAA
As the storm progresses, residents in affected areas are advised to stay updated on weather alerts and follow safety guidelines to minimize risks and potential damage.
You've probably already noticed that the prices of many foods in your shopping cart have increased significantly. In the UK, the price of white potatoes is 20% increase in the past yearwith carrots 38% increase Olive oil rose 40%. And while that means the cost of assembling a roast dinner has soared, specialty items have also seen an even bigger price increase, with you now paying nearly twice as much for a portion of a chocolate bar. It will be.
The drivers of price increases are complex, but one of the biggest drivers is climate change. In the short term, extreme weather caused by global warming is having a devastating impact on producers. For example, in Northern Europe, heavy rains in the spring of 2024 left fields too waterlogged to harvest vegetables or plant new crops. Meanwhile, Morocco, which normally exports many vegetables to Europe, experienced a drought and ran out of water for irrigation. As a result, the prices of potatoes and carrots have soared.
As average global temperatures rise by 1.5°C above pre-industrial levels in the coming years, heat waves, droughts and extreme storms will become more common and intense, causing major disruptions to food production. It will be. But current efforts to compensate for the effects of crop failures, such as clearing forests to grow more crops, are exacerbating many other problems, from biodiversity loss to rising carbon dioxide levels. I am. Are we underestimating the magnitude of the impact, when it's already happening to so many foods? If so, what can we do about it?
COVID-19 could have lasting effects on our mental and physical health
Alexander Davidov / Alamy
There is evidence that people who were hospitalized with COVID-19 during the first wave of the pandemic still have lower than expected cognitive abilities several years later, forcing them to change jobs.
“What we found is that the average cognitive impairment is equivalent to 10 IQ points, based on what you would expect given age etc.” Maxim Take At Oxford University.
His team looked at 475 British people who had been admitted to and discharged from hospital with COVID-19 up to March 31, 2021.. All of the participants had undergone psychiatric and cognitive evaluations six months after they were discharged, as part of a separate study. Take's team asked them to be reassessed two to three years later and found that, on average, symptoms of depression, anxiety, and fatigue had worsened. “More people get worse than they get better,” Take says.
Overall, those suffering from moderate to severe depression increased from 34% at six months to 47% at the second assessment, and those suffering from moderate to severe fatigue increased from 26% at the first test to 40%. Smaller changes were seen in the proportion of those suffering from moderate to severe anxiety, increasing from 23% to 27%.
It's not clear why so many people's symptoms worsened, but the team found that people whose symptoms were more severe in the initial tests tended to get worse over time. One participant said he'd had shortness of breath for three years and it was hard for him not to fall into depression, Take said.
The team also found that more than a quarter of participants changed jobs after hospitalization, half of whom said they did so because of poor health. The researchers found a strong association between changing jobs and declining cognitive function, but not with depression, anxiety, or fatigue. This suggests that many people are changing jobs because they can no longer cope with the cognitive demands of their previous jobs, rather than for a lack of energy or interest, Take says.
He acknowledges that the study has some major limitations: Only a fifth of those invited to take part actually did so, so it's not clear how representative the study is, and because participants weren't tested before being admitted to hospital, there's no baseline to compare it to, team members say. Paul Harrison also conducted at Oxford University. Instead, the conclusion that people lost 10 IQ points on average was based on what would be expected for people of the same age, sex and education level, British Intelligence Test.
The ancient relationship between Mexico City and water dates back to the city’s origins. Situated on a former lakebed that was drained after the Spanish conquest in the 16th century, the city now relies on underground aquifers and a network of canals, dams, and reservoirs from the Kutsamara water system for its main water supply.
Approximately 70% of the city’s water comes from underground sources, with the remaining 30% supplied by the Cuzamara system to the Mexico City metropolitan area and the Toluca Valley. However, increasing urbanization and overuse of aquifers have led to land subsidence, causing the city to sink at a rate of about 20 inches per year since 1950 due to continued groundwater extraction.
Despite efforts to repair and upgrade aging infrastructure, Mexico City’s water system struggles to keep pace with the demands of a rapidly growing population. Climate change further exacerbates the water crisis, with persistent drought and rising temperatures leading to decreased precipitation and limited water replenishment for aquifers and dams.
This water scarcity crisis has sparked protests and unrest among residents, with many areas facing severe water shortages. Efforts to conserve water and prioritize its usage have been urged by local authorities, as communities like Iztapalapa struggle to cope with limited water access.
For residents like Hernández Villa, conserving water has become a daily challenge, with measures like reducing laundry frequency and bathing in containers to stretch their limited water supply. The urgent need for sustainable water management and infrastructure upgrades is evident, as Mexico City grapples with a worsening water crisis.
Dennis Chou reported from New York City and Alvinson Linares from Mexico City.
New treatment cuts the gene for kallikrein, a protein involved in inflammation (illustrated)
BIOSYM TECHNOLOGIES, INC./Science Photo Library
Nine people with a rare genetic disease that causes a life-threatening inflammatory response appear to have been cured after taking part in the first trial of a new version of CRISPR-based gene therapy.
This condition, called hereditary angioedema, causes sudden swelling of tissue that affects parts of the body such as the face and throat, similar to aspects of an allergic reaction, but cannot be treated with anti-allergy drugs.
Ten people who received a one-time gene therapy administered directly into the body saw a 95 per cent reduction in the number of 'swelling attacks' in the first six months after the treatment took effect. . Since then, all but one have had no further seizures for at least a year, although one patient who received the lowest dose had one mild seizure. “This is potentially a cure,” he says Padmalal Gurugama At Cambridge University Hospital in the UK, we worked on a new approach.
Hereditary angioedema is usually caused by mutations in the gene that encodes a protein called C1 inhibitor, which is involved in suppressing inflammation, which is part of the immune response.
People with this condition may experience a sudden buildup of fluid under their skin several times a month, which is painful and can cause suffocation if it gets stuck in the throat. This attack can be caused by a virus, changes in hormone levels, or stress.
Existing drugs that can reverse attacks work by blocking another molecule involved in inflammation called kallikrein, which is made in the liver. Because people can be born without the ability to make kallikrein without adverse effects, the results suggest that it is safe to permanently block kallikrein through gene therapy, Gurgama said.
The new treatment, developed by a company called Intellia Therapeutics in Cambridge, Massachusetts, consists of genetic material designed to cut the kallikrein gene. It is encapsulated in lipid nanoparticles and taken up by liver cells. One person was treated in the UK and nine in New Zealand and the Netherlands.
An unusual feature of this therapy is that it is administered directly to humans, a method also referred to as “in vivo” delivery. “They get one infusion and that's it,” he says. julian gilmore from University College London was not involved in the study. “It's very appealing.”
So far, most other CRISPR-based gene therapies have been administered “outside the body.” This means a more complex and time-consuming procedure of taking some of a person's cells outside the body, changing the cells in a lab, and then reinjecting them.
CRISPR gene therapy is being developed for multiple genetic diseases, with the first treatments recently approved in the UK and US to help patients with two forms of genetic anemia: sickle cell disease and beta-thalassemia. Ta.
The success of the latest trial is “very exciting,” Gilmore said. Development of CRISPR-based treatments for people with various liver-related conditions, called transthyretin amyloidosis. “This technology could be applied to any disease caused by a mutant protein produced exclusively in the liver, where it is desirable to knock down that protein,” he says.
A coronavirus vaccine is being administered at Epsom Racecourse in Surrey, England.
PA Image/Alamy
Around 7,000 people in the UK would have avoided dying or being hospitalized from coronavirus in the summer of 2022 if they had been fully vaccinated against the virus, a major study has found. This is the first time that the health impact of hesitancy to get a COVID-19 vaccine has been calculated on a national basis.
Since the emergence of the Omicron variant, covid-19 vaccines are less effective at preventing people from getting infected, but they still reduce the risk of dying or needing hospitalization from the virus.
katherine sudlow Researchers at the University of Edinburgh in the UK used national health service data to determine how much vaccination would reduce hospitalizations and deaths in the summer of 2022, when most COVID-19 restrictions had ended. We investigated whether it had an impact on
Sudlow's team included data from June 1 to September 30, 2022, spanning the wave of coronavirus infections that peaked in July. During this period, 40,000 people died or required hospitalization due to the virus, all of which were classified as serious health hazards.
The team then looked at people who have received the recommended number of COVID-19 vaccines and boosters (for example, four doses for people 75 and older by that point) and those who have received fewer than the recommended number of doses. They compared rates of severe outcomes among people who received the vaccine or booster immunization. Not at all.
People who have not been fully vaccinated are more likely to develop severe disease than people who are fully vaccinated, and the exact increased risk depends on age. For example, people over the age of 75 are about three times more likely to develop severe illness from COVID-19 if they have not been fully vaccinated.
The researchers calculated that if everyone in the UK had been fully vaccinated, there would have been around 7,000 fewer deaths and hospital admissions. “Fully immunizing people will reduce adverse outcomes for society as a whole,” Sudlow said.
One caveat is that this study was not a randomized trial, which is the best medical evidence, but simply observed a correlation between vaccination status and outcome, which could bias the results. The fact is that there is, he said. stephen evans At the London School of Hygiene and Tropical Medicine.
Nevertheless, he says the results of studies on the vaccine's effectiveness are broadly consistent with previous randomized trials. “Their approach is a reasonable one.”
This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.
Strictly Necessary Cookies
Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings.
