The Unsettling Reality of Medical Cannabis and Its Impact on Mental Health

In 2018, the legalization of medical cannabis in the UK marked a pivotal change, driven by campaigns advocating for children with treatment-resistant epilepsy.

The legal reforms permit specialist medical consultants to prescribe cannabis-based medical products (CBPMs) for a variety of conditions, always prioritizing the patient’s well-being.

Despite this legalization, the possession and use of cannabis (classified as a class B drug) without a valid prescription continues to be illegal in the UK.

Most cannabis products available are unlicensed, lacking endorsement from the Medicines and Healthcare products Regulatory Agency (MHRA), resulting in limited prescriptions through the National Health Service (NHS). This gap has inadvertently triggered a burgeoning private market.

Currently, more than 30 specialist cannabis clinics are registered with the Healthcare Quality Commission, with estimated prescriptions for cannabis products reaching 80,000 patients. Conditions treated range from chronic pain and anxiety to ADHD.

Data reveals that 42% of patients were prescribed medical cannabis for mental health issues such as anxiety, depression, PTSD, and OCD, aligning with trends observed in Australia and the US.

The UK stands as a major producer of medical cannabis. Photo courtesy of Getty.

However, a recent review published in Lancet Psychiatry assessed over 50 randomized controlled trials (RCTs) and found “no evidence” supporting the efficacy of cannabinoids for treating conditions like anxiety, PTSD, substance use disorders, ADHD, bipolar disorder, psychotic disorders, or anorexia.

While some efficacy was noted for cannabis use disorder, insomnia, Tourette syndrome, and autism spectrum disorder, these findings were categorized as “low quality.”

The Advisory Committee on the Abuse of Drugs (ACMD) is conducting a review examining the implications of medical cannabis prescriptions in the UK, focusing on any “unintended consequences” resulting from recent legal changes.

Professor Owen Bowden Jones, former ACMD Chairman, indicated that the study results indicate that the benefits of medical cannabis may have been “overestimated” for numerous conditions, and these products “should not be administered for psychiatric conditions lacking supportive evidence.”

“We must focus on reducing barriers to facilitate superior research that further explores cannabis product effects,” he added.

The review asserts that routine cannabinoid use for mental health conditions is “seldom justified,” raising critical questions, notably, why is cannabis prescribed despite limited evidence of its effectiveness?

Treatment Options

It is stated that “absence of evidence is not evidence of absence.” Dr. Niraj Singh, a consultant psychiatrist in the UK, has prescribed medical cannabis for over six years.

“Numerous patients have reported that this treatment effectively addresses a range of conditions, and most use it responsibly. In my experience, it has yielded positive results, enabling patients to lead happy, fulfilling lives,” Singh remarked.

Many patients seeking treatment at cannabis clinics have reportedly exhausted all traditional options or lack access to adequate mental health support. As of January 2026, 1.5 million adults engaged with NHS mental health services, while 8.7 million people were prescribed antidepressants in the UK from 2023 to 2024, believed to be effective for approximately one year.

In a survey by the United Patient Alliance, a patient dealing with anxiety, depression, and PTSD expressed feeling “seen and supported” after receiving effective treatment without harmful side effects associated with previous prescriptions.

“In instances where individuals have plateaued in treatment options, medical cannabis is making a significant difference,” Singh expressed.

Evidence from peer-reviewed studies links cannabis to improved symptoms and quality of life for conditions such as: PTSD, OCD, and insomnia. However, observational studies were excluded from the aforementioned review due to concerns of biases that could not establish causality.

Despite the need for more robust clinical trials, Professor David Nutt, former chair of ACMD and founder of the independent charity Drug Science, argues that RCTs alone do not offer sufficient data on a drug’s effectiveness.

This sentiment is echoed by Sir Michael Rollins, former director of the MHRA and the National Institute for Healthcare Research and Evaluation (NICE). He emphasized the need for real-world evidence that could yield “better clinical data and statistical power” in a speech at the Royal College of Physicians.

According to Nutt, “Placebo-controlled trials are costly and involve highly selective patient populations, limiting their generalizability.” He also highlighted that cannabis’s numerous active compounds, which vary vastly in dosage and formulation, pose significant challenges when conducting double-blind, placebo-controlled studies. Professor Mike Burns, President of the Association of Medical Cannabis Clinicians, emphasized the need for a more nuanced approach in understanding mental health prescribing.

Clinical Supervision

Medical cannabis can induce side effects, including heightened anxiety and paranoia, making it unsuitable for individuals with a history of psychosis.

According to a survey published in BMJ Mental Health, those using cannabis for self-medication tend to use it more frequently and consume higher levels of tetrahydrocannabinol (THC), resulting in increased paranoia.

“Cannabis is not devoid of side effects,” stated Dr. Marta Di Forti, a Professor of Drug Use, Genetics, and Psychosis at King’s College London, who runs a clinic for individuals with mental health issues in London.

She recounted cases where patients developed complications after being prescribed products containing high THC levels, leading to hospitalizations for psychotic symptoms. Yet, much of our understanding in this area remains anecdotal.

“There is valid reasoning for prescribing cannabis as medication,” she noted. “However, there must be comprehensive evidence and proper oversight, which is currently lacking.”

The Association of Medical Cannabis Clinicians recommends a review by a peer panel for prescriptions exceeding 60 grams per month or containing over 25% THC. Like other controlled substances, prescribing CBPM requires diligent clinical oversight, thorough evaluation, and ongoing monitoring, especially in complex cases with significant mental health histories.

While Singh noted that side effects are relatively rare, he expressed concern about the rising availability of high-THC products. “Checks and balances are imperative,” he insisted, “as adjustments to THC concentrations must be carefully monitored.”

Prescribers maintain that a strong clinical oversight process is in place, stating they’ve never felt pressure to prescribe. Eligibility for medical cannabis entails having undergone at least two previous treatments, receiving an evaluation from a psychiatrist, and being reviewed by a multidisciplinary team.

Nonetheless, some critics argue that clinics should enhance support and training for prescribers and have a responsibility to foster research that substantiates their claims. “The industry has not adequately collected and analyzed patient outcomes,” Burns stated. “Clinics have a moral obligation to gather and share data whenever possible.”

In 2018, cannabis became legal for medical use in the UK with a prescription. Use without a prescription remains illegal. Photo credit: Getty.

Evidence Gap

There is a shared consensus on the urgent need to develop a robust evidence base. However, finding common ground proves challenging. Some advocate for cannabis’s efficacy, while others dispute it, with a lack of substantial research to confirm either stance.

Nutt emphasized that the current clinical research system is inadequate for medical cannabis. “In 2018, the Health Ministry pledged to conduct efficacy trials for children with epilepsy, but no progress has been made. This reflects a disinterest from pharmaceutical companies due to the impossibility of patenting plant medicines.”

This challenge cannot be solved solely by a call for further research, he noted, but requires prioritizing real-world data and practical experience to support cannabis in clinical settings.

Meanwhile, patients express fears of being pushed back into the illegal market, where they have no access to medical oversight or regulated products, which is widely viewed as more dangerous.

Denying access to medical marijuana based on “incomplete evidence” not only misrepresents scientific data but also inflicts harm on patients who rely on it, according to the United Patient Alliance.

“Real-world evidence studies, patient-reported outcomes, and research focusing on treatment-resistant populations are critically needed,” they added. “We do not ask for science to be ignored; we urge it to catch up with patient experiences.”

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Source: www.sciencefocus.com

NASA Astronaut’s Medical Emergency Leads to Historic First Ever ISS Escape

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NASA astronaut Mike Finke discusses the medical issues that led to the historic evacuation from the International Space Station earlier this year.



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Source: www.nbcnews.com

Neanderthals Used Birch Tar as a Natural Antibiotic: Discovering Ancient Medical Practices

Recent research highlights that birch bark tar—historically recognized as a natural tool adhesive—can effectively inhibit harmful bacteria like: Staphylococcus aureus. This suggests that Neanderthals may have utilized it to treat wounds and manage infections during the Ice Age.

Neanderthals likely employed birch tar for various applications, including wound care. Siemsen et al. confirmed that birch tar possesses selective antibacterial properties and effectively inhibits Staphylococcus aureus.

Birch tar is frequently discovered at Neanderthal sites, where it is known to have served as an adhesive for crafting tools.

Recent inquiries suggest that Neanderthals may have had additional uses for this versatile substance.

For instance, indigenous communities in Northern Europe and Canada have utilized birch tar to treat injuries. Increasing evidence indicates that Neanderthals also engaged in various medicinal practices.

To explore the medicinal capabilities of birch tar, Dr. Tjaark Siemssen and his team from the Universities of Cologne and Oxford extracted tar from birch tree bark, particularly species identified at Neanderthal sites.

The researchers employed multiple extraction techniques, including distillation in clay pits and condensation on stone surfaces—methods that Neanderthals could also have accessed.

All tested tar samples showcased effectiveness in inhibiting bacterial growth against various strains, including the notorious Staphylococcus bacteria responsible for wound infections.

These findings not only reinforce the efficacy of indigenous medicinal practices but also lend credence to the possibility that Neanderthals used birch tar for therapeutic purposes.

The researchers note that birch tar, alongside other available plants, may serve additional roles, such as an insect repellent.

Further investigations into the diverse applications of these natural substances will enrich our understanding of Neanderthal culture.

“Our findings demonstrate that birch tar produced by Neanderthals and early humans possesses notable antibacterial properties,” the researchers stated.

“This discovery has significant implications for how Neanderthals managed disease burdens during the last Ice Age and contributes to the expanding knowledge of medicine among early human communities.”

“Integrating research in indigenous pharmacology and experimental archaeology enhances our understanding of the medical practices of our early ancestors and their closest relatives.”

“Moreover, this paleopharmacological research could assist in rediscovering antibiotic treatments as we confront a rising crisis of antimicrobial resistance.”

“The intricate processes involved in birch tar production are noteworthy.”

“Each stage of production was a sensory journey, and the challenge of cleaning tar from my hands after hours by the fire was a central experience every time.”

For more detailed insights, refer to the study published in the journal PLoS ONE.

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T. Ziemsen et al. 2026. Antibacterial properties of experimentally produced birch tar and its medicinal efficacy in the Pleistocene. PLoS One 21 (3): e0343618; doi: 10.1371/journal.pone.0343618

Source: www.sci.news

NASA Identifies Astronaut Involved in Medical Incident on the ISS

Astronauts Finke, Cardman, Yui, and Platonov have been stationed on the International Space Station (ISS) since early August, with plans originally extending until late February.

However, following an incident, NASA executives and the agency’s medical director decided to bring the astronauts back to Earth one week early.

Finke stated, “After a thorough evaluation, NASA has concluded that the safest decision is to return Crew-11 early. It is not an emergency; rather, it is a crafted plan to utilize advanced medical imaging technology not accessible on the space station.”

The Crew-11 astronauts departed the ISS on January 14, undocking from the space station in the same SpaceX Dragon capsule that initially transported them. Following an 11-hour journey, the capsule landed in the Pacific Ocean off the San Diego coast during the early morning hours on January 15.

NASA Administrator Jared Isaacman remarked in a post-landing news conference that while there were “serious conditions” in orbit, the crew has remained safe and stable since the incident.

Finke expressed gratitude towards his Crew-11 teammates, including NASA astronaut Chris Williams and Russian cosmonauts Sergei Kud Sverchkov and Sergei Mikayev. He also acknowledged the instrumental support from the teams at NASA, SpaceX, and medical professionals at Scripps Memorial Hospital La Jolla.

“Their professionalism and commitment undoubtedly led to positive outcomes,” he added.

Finke concluded by sharing that he is “doing very well” and is engaging in standard post-flight repair work at NASA’s Johnson Space Center in Houston.

“Spaceflight is an incredible privilege that humbles our humanity,” he said. “Thank you for your continued support.”

Source: www.nbcnews.com

Ancient Bacteria Discovery Redefines Syphilis Origins: A Breakthrough in Medical History

Treponema pallidum Bacteria Linked to Syphilis and Related Diseases

Source: Science Photo Library / Alamy

New research reveals that traces of Treponema pallidum—the bacteria responsible for syphilis—have been identified in the bones of ancient inhabitants of Colombia, dating back over 5,000 years. This discovery suggests that syphilis was infecting humans far earlier than previously believed, prior to the advent of intensive agriculture, which many experts think may have facilitated its spread.

Currently, Treponema pallidum encompasses three subspecies that cause syphilis, bejel, and framboise. The origins and transmission pathways of these diseases remain topics of scientific debate. Although ancient DNA and infectious markers on bones offer insights, they are often limited and ambiguous.

In a groundbreaking study, researchers analyzed DNA from 5,500-year-old remains discovered in the Bogotá savannah. The unexpected finding of Treponema pallidum in a human leg bone provides critical evidence of its historical prevalence.

“This discovery was entirely unanticipated, as there was a lack of skeletal evidence indicating an infectious disease,” notes Nasreen Broumandkoshbacht from the University of California, Santa Cruz.

Many scholars have long posited that the majority of diseases affected humans only after the rise of intensive agriculture, which led to denser populations. However, this individual lived in a contrasting setting—small, nomadic hunter-gatherer bands that maintained close contact with wild animals.

“These results shed light on the extensive evolutionary history of these organisms,” states Davide Bozzi from the University of Lausanne, Switzerland. “They reveal longstanding relationships between the bacterium and human populations.”

As researchers, including Blumandhoschbacht and Bozzi, correlated ancient genomes with contemporary ones, they identified that the pallidum strain was part of a distinct lineage, separate from any known modern relatives. This indicates that early variants of syphilis were already diversifying and infecting humans in the Americas millennia ago, with many of the same genetic traits that make present-day strains particularly pathogenic.

The findings imply that these pathogens were not only early residents in the Americas but may have been affecting human populations globally for much longer than previously assumed.

Rodrigo Barquera, a researcher at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, suggests that this ancient strain might link to an elusive “missing” pathogen, Treponema carathaeum, known primarily for its physical characteristics rather than its genetic makeup.

Kertu Majumdar, a researcher at the University of Zurich in Switzerland, posits, “The genomes of even older organisms might provide insights into a variety of extinct lineages and diseases caused by these pathogens.”

For Bozzi, unearthing the evolutionary adaptations of pathogens like syphilis is crucial for understanding their genetic attributes that enhance their virulence in new hosts.

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Source: www.newscientist.com

Nasa Astronaut Set to Depart Space Station for Medical Reasons

Four astronauts are set to return from the International Space Station (ISS) on Wednesday night, departing weeks earlier than originally planned due to health concerns.

NASA astronauts Zena Cardman and Mike Finke, alongside Japanese cosmonaut Kamiya Yui and Russian cosmonaut Oleg Platonov, will make their journey back to Earth aboard the same SpaceX Dragon capsule that previously transported them to the ISS. This group, known as “Crew-11,” is expected to undock at around 5:05 p.m. ET.

This incident marks the first time in the ISS’s 25-year history that a mission has had to be cut short due to a medical issue while in orbit. Though NASA has not disclosed specifics regarding the affected crew members or the nature of their medical issues, citing privacy concerns, officials reassured the public that the situation is stable and does not warrant an emergency evacuation.

“First and foremost, we’re all okay,” Finke stated in a LinkedIn post over the weekend. “Everyone on board is stable, safe, and well cared for. This decision allows for a comprehensive medical evaluation on the ground where all diagnostic capabilities exist. This is the correct decision, even if it feels somewhat bittersweet.”

If undocking proceeds as scheduled, Crew-11 astronauts are anticipated to splash down in the Pacific Ocean off California’s coast around 3:41 a.m. ET on Thursday. The journey back will take approximately 11 hours, including a deorbit burn to slow the spacecraft before it re-enters Earth’s atmosphere, culminating in a parachute landing underwater.

Arriving at the ISS in August, Cardman, Finke, Yui, and Platonov were initially slated to remain until the end of February. However, a recent medical incident involving a crew member led NASA to cancel a planned spacewalk, which Cardman and Finke were set to conduct for station exterior renovations. Following this, the decision was made to expedite the crew’s return as a precautionary measure.

“After thorough consultation with Chief Medical Officer Dr. J.D. Polk and various agency leaders, we concluded that it is in the best interest of the astronauts to return Crew-11 ahead of the original schedule,” stated NASA Administrator Jared Isaacman on Thursday.

The astronauts are expected to land on Earth before the next space station crew takes off, but NASA confirms that Flight Engineer Chris Williams and two Russian cosmonauts will remain aboard. NASA officials are exploring options to expedite the next launch. The upcoming mission, known as Crew 12, is planned for a launch by February 15, but Williams will presumably be the sole NASA astronaut managing U.S. scientific experiments and operations on the ISS for several weeks.

During a “change of command” ceremony prior to departure on Monday, Finke officially handed over command of the space station to cosmonaut Sergei Kud-Sverchkov.

“Sergei, it is both an honor and a pleasure to hand over command to you,” Finke remarked.

He referred to the crew’s unexpectedly early departure as “an interesting time,” reminiscing positively about their experience in orbit.

“We come from diverse places around the globe and work collaboratively,” Finke concluded. “This is a fantastic representation of what humanity can achieve together.”

Source: www.nbcnews.com

NASA Schedules Astronauts’ Early Departure from ISS Amid Medical Concerns

NASA has announced plans to return four astronauts from the International Space Station (ISS) earlier than initially scheduled due to a crew member’s health issue encountered in orbit.

According to a statement released by NASA late Friday, the undocking from the ISS is set to take place by 5 p.m. ET on Wednesday, weather permitting at the designated splashdown site off California’s coast.

This marks the first occasion in the 25-year history of the ISS that a mission has been interrupted due to a medical incident in space.

While NASA confirmed a medical issue arose earlier this week, specific details regarding the crew member’s condition or identity have not been disclosed, citing medical privacy regulations.

During a news conference on Thursday, agency officials reassured that the situation is stable, and the decision for early departure is a precautionary measure rather than an emergency evacuation.

NASA Administrator Jared Isaacman stated, “After consulting with Chief Medical Officer Dr. J.D. Polk and agency leaders, we concluded that it’s best for the astronauts to return Crew-11 ahead of schedule.”

The returning crew includes NASA astronauts Zena Cardman and Mike Finke, Japanese astronaut Kamiya Yui, and Russian cosmonaut Oleg Platonov. Crew-11 was initially slated to reach the ISS in early August and remain in the laboratory until late February.

The astronauts will return in the same SpaceX Dragon capsule that transported them to the ISS. If all goes as planned, undocking will occur Wednesday night, with an expected splashdown in the Pacific Ocean around 3:40 a.m. Thursday.

NASA and SpaceX will provide further updates on the precise landing time and location as it gets closer to the undocking.

Post Crew-11’s departure, NASA will maintain one astronaut aboard the ISS to oversee U.S. scientific experiments and operations. Flight engineer Chris Williams launched aboard a Russian Soyuz spacecraft on November 27th and will be joined by Russian cosmonauts Sergei Kud-Sverchkov and Sergei Mikayev.

The next crew is scheduled to launch to the ISS in mid-February, with NASA considering enhancements to this mission, known as Crew-12.

Source: www.nbcnews.com

NASA Executes Unprecedented Medical Evacuation from the International Space Station (ISS)

NASA’s SpaceX Crew-11 Team to the International Space Station

SpaceX

In a historic event, astronauts have been evacuated from the International Space Station (ISS) for medical reasons for the first time. The specific medical condition has not been disclosed to maintain privacy, and the astronaut affected remains unnamed. However, four of the seven crew members aboard the ISS returned to Earth ahead of schedule.

The returning astronauts are part of the Crew-11 mission, which launched on August 1 and was initially scheduled to conclude in late February. During a press conference on January 8, NASA Administrator Jared Isaacman noted that nearly all mission objectives had been achieved, enabling an early return.

“This is not an emergency evacuation; the astronaut is stable,” stated NASA’s Chief Medical Officer James Polk. Isaacman further emphasized that while emergency medical evacuation was possible within hours, the actual crew evacuation would occur within days.

Although medical incidents aboard the ISS are not unprecedented, they have typically been manageable in orbit. “The ISS is equipped with robust medical facilities, but it lacks the comprehensive resources of an emergency department,” Polk explained. The severity of this recent incident necessitated that the crew return to Earth for complete medical assessment.

The four Crew-11 members (including two NASA astronauts, one Russian, and one Japanese astronaut) will return via the Dragon spacecraft that transported them to the ISS, despite only one experiencing a medical issue. Preparations are in place at Earth-based medical facilities to ensure affected crew members receive the necessary care. While the situation is without precedent, Isaacman assured that the return process aligns closely with regular protocols.

“Historical models over the last 25 years suggest medical evacuations should occur approximately every three years, yet this is the first such instance,” Polk remarked.

Following this evacuation, a NASA astronaut and two Russian cosmonauts will continue their research aboard the ISS until the Crew-12 mission arrives, originally planned for February 15, but potentially rescheduled due to this incident.

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Source: www.newscientist.com

NASA to Return Space Station Astronauts Early Due to Medical Concerns

NASA has announced that four astronauts aboard the International Space Station (ISS) will return to Earth over a month early due to medical issues. This unprecedented evacuation marks the first of its kind in the ISS’s 25-year history.

Due to medical privacy regulations, NASA refrained from disclosing specific details, including the identities of the affected astronauts and the nature of their medical conditions. However, officials confirmed that the overall situation remains stable.

Speaking at a recent news conference, NASA Administrator Jared Isaacman stated that the astronauts are expected to return home in the coming days. An exact timeline for undocking and landing has not yet been provided.

“After consulting with Medical Officer of Health Dr. J.D. Polk and leadership across the agency, we believe returning Crew-11 early is in the best interest of the astronauts,” Isaacman said in a statement.

Inside the International Space Station.
NASA

Isaacman noted that further updates would be available within the next 48 hours.

The Crew-11 team evacuating the ISS consists of NASA astronauts Zena Cardman and Mike Finke, Japanese cosmonaut Kamiya Yui, and Russian cosmonaut Oleg Platonov. They had originally arrived in early August with plans to stay until late February.

Dr. Polk reassured the public that the situation is stable, clarifying that the decision to evacuate was made for the well-being of the astronauts, not due to an emergency.

“While the ISS is equipped with sophisticated medical technology, it cannot match the complete resources of a hospital emergency department for thorough patient evaluations,” Polk explained. “In this case, there were multiple medical events which necessitated a careful assessment of the astronauts’ health.”

NASA first made the medical concerns public on Wednesday, when it was revealed that Cardman and Finke were deferring a scheduled spacewalk.

Following the early return of Crew-11, NASA will operate with just one astronaut on the ISS, who will oversee ongoing U.S. scientific operations. Flight engineer Chris Williams launched aboard a Russian Soyuz spacecraft on November 27, accompanied by Russian cosmonauts Oleg Platonov, Sergei Kud-Sverchkov, and Sergei Mikayev.

The subsequent crew is slated to launch to the ISS in mid-February, but Isaacman indicated that NASA may evaluate enhancements for this upcoming mission, known as Crew-12.

This week’s developments present Isaacman’s first significant challenge since taking office on December 18.

Source: www.nbcnews.com

Experts Warn AI May Complicate Accountability in Medical Errors

Experts are cautioning that the integration of artificial intelligence in healthcare may lead to a legally intricate blame game when determining responsibility for medical errors.

The field of AI for clinical applications is rapidly advancing, with researchers developing an array of tools, from algorithms for scan interpretation to systems for assisting in diagnosis. AI is also being designed to improve hospital operations, such as enhancing bed utilization and addressing supply chain issues.

While specialists acknowledge the potential benefits of this technology in healthcare, they express concerns regarding insufficient testing of AI tools’ effectiveness and uncertainties about accountability in cases of negative patient outcomes.

“There will undoubtedly be situations where there’s a perception that something has gone awry, and people will seek someone to blame,” remarked Derek Angus, a professor at the University of Pittsburgh.

The Journal of the American Medical Association hosted the Jama Summit on Artificial Intelligence last year, gathering experts from various fields, including clinicians, tech companies, regulatory bodies, insurers, ethicists, lawyers, and economists.

According to the report of results, of which Angus is the lead author, the publication discusses the nature of AI tools, their application in healthcare, and the various challenges they present, including legal implications.

Co-author Glenn Cohen, a Harvard Law School professor, indicated that patients might find it challenging to demonstrate negligence concerning AI product usage or design. Accessing information about these systems can be difficult, and proposing reasonable alternative designs or linking adverse outcomes to the AI system may prove unwieldy.

“Interactions among involved parties can complicate litigation,” he noted. “Each party may blame the others, have pre-existing agreements redistributing liability, and may pursue restitution actions.”

Michel Mello, a Stanford Law School professor and another report author, stated that while courts are generally equipped to handle legal matters, the process can be slow and create early-stage mismatches. “This uncertainty increases costs for everyone engaged in the AI innovation and adoption ecosystem,” she remarked.

The report also highlights concerns regarding the evaluation of AI tools, pointing out that many fall outside the jurisdiction of regulatory bodies like the U.S. Food and Drug Administration (FDA).

Angus commented, “For clinicians, efficacy typically translates to improved health outcomes, but there’s no assurance that regulators will mandate evidence.” He added that once an AI tool is launched, its application can vary widely among users of differing skills, in diverse clinical environments, and with various patient types. There’s little certainty that what seems advantageous in a pre-approval context will manifest as intended.

The report details numerous obstacles to evaluating AI tools, noting that clinical application is often necessary for thorough evaluation, while current assessment methods can be prohibitively expensive and cumbersome.

Mr. Angus emphasized that investing in digital infrastructure is crucial and that adequate funding is essential for effectively assessing AI tools’ performance in healthcare. “One point raised during the summit was that the most respected tools are often the least utilized, whereas the most adopted tools tend to be the least valued.”

Source: www.theguardian.com

Ways to Deter Individuals from Pursuing Medical Care: Tips and Slang

Exercise caution when seeking AI advice on medical issues

Chong Kee Siong/Getty Images

Wondering whether to consult a doctor about your sore throat? The quality of AI recommendations can vary based on how you frame your questions. In experiments with AI models, users who made typos, expressed uncertainty, or were identified as women were more frequently advised to seek medical attention.

“Subtle biases can shape the nature and content of AI recommendations, significantly affecting the distribution of medical resources.” Karandeep Singh, who did not participate in the research at the University of California, San Diego, commented.

Avinisa Gravatina and her team at Massachusetts Institute of Technology have harnessed AI to produce thousands of patient notes in various formats. Some messages included intentional errors and spaces to replicate the writing style of individuals with limited English skills or typing difficulties, while others utilized uncertain language to reflect different emotional tones, including health anxiety or gendered expressions.

The researchers presented these notes to four widely-used large language models (LLMs) that power many chatbot applications, asking them if patients should manage their conditions independently, visit clinics, or undergo certain tests. The models included OpenAI’s GPT-4, Meta’s Llama-3-70b, Llama-3-8b, and the Palmyra-Med model created specifically for healthcare by AI specialists.

Results indicated that variations in format and style influenced the recommendations, with 7-9% of the AI models suggesting that patients remain at home rather than seek medical appointments. Additionally, female patients were more likely to receive recommendations to stay home. A study highlighted that treatment suggestions were more susceptible to changes based on the gender and language style of the queries than those offered by human clinicians.

OpenAI and Meta did not respond to inquiries for comments. According to Zayed Yasin, a writer involved in the research, these LLMs are not intended for health advice or clinical recommendations without human oversight.

Most operational AI technologies in electronic health records currently depend on OpenAI’s GPT-4 O, which wasn’t directly studied here. Singh emphasized the necessity for enhanced methods to assess and monitor generative AI models within the healthcare sector.

Topics:

Source: www.newscientist.com

Chimpanzee Medical Care and Hygiene Are More Common Than You Might Think

Primatologists have recorded and examined both previously noted and newly observed instances of self-administered and socially oriented wound care, snare removal, and potential medicinal hygiene behaviors within the Sonso and Waibira chimpanzee communities of the Budonggo forests in Uganda. They documented self-directed wound care actions, such as licking wounds, slapping leaves, pushing fingers against wounds, applying plant material to injuries, and successfully removing snares. The researchers also noted self-guided hygiene behaviors, including cleaning genital areas with koital leaves and wiping foliage post-defense.

Social grooming between two chimpanzees in Budonggo forest, Uganda. Image credit: Elodie Freymann.

“Our research sheds light on the evolutionary origins of human medicine and healthcare systems,” stated the first author of the study, Dr. Elodie Freyman, a researcher at Oxford University.

“By observing how chimpanzees identify and utilize medicinal plants to care for others, we can gain valuable insights into the cognitive and social foundations of human medical practices.”

Dr. Freyman and his team focused their study on the Sonso and Waibira chimpanzee communities in Budonggo forest.

Like all chimpanzees, individuals in these communities face injuries from various causes, including human-instigated fights, accidents, or snares.

Approximately 40% of all Sonso individuals are observed with snare injuries.

The researchers dedicated four months to each community’s observation, employing video evidence from a comprehensive APE dictionary database, a logbook filled with decades of observational data, and research gathered by other scientists who have witnessed chimpanzees treating injuries and illnesses.

Chimpanzees have been noted to use specific plants for external treatment. Some have been identified to possess chemical properties that enhance wound healing and traditional medicinal applications.

During their field observations, scientists noted 12 injuries at Sonso, all likely resulting from group conflicts.

In Wyvila, five chimpanzees were documented as injured—one female from a snare and four males from combat.

https://www.youtube.com/watch?v=Amnbsz6uvfq

Researchers also recognized that care was provided for their offspring rather than Waibira.

“This may be influenced by factors like variations in social hierarchy stability and greater observation opportunities in the well-acquainted Sonso community,” noted Dr. Freyman.

The scientists recorded a total of 41 care instances: seven instances of prosocial care and 34 instances of self-care.

These instances frequently involved various care behaviors, whether addressing different aspects of a wound or indicating the chimpanzee’s personal preferences.

“Chimpanzee wound care involves several techniques, which can remove debris and apply potentially antibacterial substances, possibly even antibiotics from their saliva.”

“All chimpanzees documented in our study exhibited recovery from their wounds, yet we are unable to determine the outcome had they chosen not to address their injuries.”

“We also recorded hygienic behaviors such as using leaves to clean the genitals post-mating and wiping the anus with leaves after defecation—practices that serve to prevent infections.”

Among the seven instances of prosocial care, the researchers noted four instances of wound treatment, two instances of assistance in snare removal, and one instance involving hygiene help for another chimpanzee.

Care was administered without preference towards a specific gender or age group. Attention was given to genetically unrelated individuals in four cases.

“These behaviors contribute to evidence from other areas where chimpanzees appear to acknowledge the needs and sufferings of others and take deliberate actions to alleviate them, even in the absence of direct genetic advantages,” Dr. Freyman stated.

The research team intends to delve deeper into the social and ecological contexts in which care is provided and which individuals are recipients of such care.

“There are some methodological limitations in our study,” Dr. Freyman added.

“The disparity in familiarity between the Sonso and Waibira communities introduces observational bias, particularly regarding rare behaviors like prosocial healthcare.”

“We have documented the plants used in healthcare contexts, but further pharmacological exploration is necessary to confirm their specific medicinal characteristics and efficacy.”

“The relative rarity of prosocial healthcare also complicates the process of identifying patterns related to when and why such care is provided, or when it is withheld.”

“These challenges underscore future research avenues in this burgeoning field.”

Study published in the journal Frontiers in Ecology and Evolution.

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Elodie Freymann et al. 2025. Self-direction and prosocial wound care, snare removal, and hygienic behavior among Budongo chimpanzees. Front. Ecol. Evol. 13; doi:10.3389/fevo.2025.154092

Source: www.sci.news

Doctors Report Immigrants Avoiding Medical Care Due to Fear of ICE

A man lay on the sidewalk in New York City, injured by a gunshot, holding his side.

Emily Bolgaard, a social worker providing supplies to the homeless through her nonprofit, discovered him and prepared to call 911. Nonetheless, the man pleaded with her not to make the call.

“No, no, no,” he insisted.

Bolgaard attempted to reassure him that federal law mandated hospitals to treat patients regardless of immigration status, but his fear was palpable.

“He expressed, ‘If I go to the emergency department, I’ll be on their radar,'” she recounted in an interview about the event.

Across the nation, healthcare professionals are increasingly worried that individuals with severe medical issues, including injuries and chronic illnesses, are forgoing treatment due to fears of arrest by immigration officials. After the Trump administration’s announcement of extensive deportation plans, the Biden administration’s strategy of safeguarding areas like hospitals and clinics has led to a noticeable increase in patient anxiety and a decrease in treatment uptake.

If this trend persists, healthcare professionals indicate that the consequences could be severe. Uncontrolled infectious diseases could spread, healthcare costs would rise due to untreated chronic conditions, and complications during childbirth may pose increased risks to women delaying care.

In a KFF survey, 31% of immigrants reported concerns that their status (or that of family members) could adversely affect their health. About 20% of all surveyed migrants shared struggles with diet and sleep, while 31% experienced increased stress and anxiety.

A White House representative did not respond to a request for comment. Following the announcement on January 21 to end protections at hospitals, a statement from the Department of Homeland Security indicated that the updated policy was “designed to enforce immigration laws and apprehend criminal foreigners.”

Research indicates that immigration enforcement actions are associated with deterioration in birth outcomes, negative mental health effects, decreased care access, and reduced public program utilization that alleviates illness and poverty.

“We are not only creating significant health risks, but also long-term economic risks for our nation,” stated Julie Linton, a pediatrician and member of the American Academy of Pediatrics’ Federal Committee. “These policies instill very real fear and uncertainty among people, drastically impacting their daily functioning.”

Numerous immigrant communities grapple with a high prevalence of chronic diseases, including hypertension and diabetes. Without treatment, this can lead to serious complications like heart attacks and strokes.

Doctors express concern for patients like Maria, a 47-year-old pre-diabetic woman who has visited the same primary care clinic since arriving in the U.S. from El Salvador two decades ago. Even during the first Trump administration’s crackdown on immigrants, she sought medical care consistently. However, after protections around hospitals were lifted earlier this year, Maria canceled her appointment to check her blood sugar.

“We are in the clinic and deeply afraid of ICE arriving while we wait,” she said in Spanish.

Maria, who requested to remain anonymous, described herself as being in “continuous anguish.” She is formulating a plan to care for her American citizen child in the event she and her husband are deported.

One of her daughters, aged 15, is being treated for fatty liver disease, while another child requires care for developmental issues. Their eldest daughter has a doctor’s appointment scheduled for June. Maria and her husband wish to continue their child’s treatment but are apprehensive about attending appointments alone. “It’s very complicated,” Maria said. “I can risk myself for my child, but when it comes to my own health, I prefer to let it go.”

The repercussions of forgoing regular medical care can escalate quickly. Jim Manzia, president of St. John’s Community Health Network in Los Angeles, described a diabetic patient who ceased attending weekly diabetes education classes. Upon contacting her, the clinic staff discovered she was too terrified to even go grocery shopping and had subsisted on tortillas and coffee for days.

“We’re thankful we managed to reach her and that she came in,” Manzia noted. The network serves approximately 25,000 undocumented patients across more than 20 locations. Clinic exams indicated her blood sugar levels were dangerously elevated.

“This is becoming increasingly common,” Manzia lamented. “It breaks my heart to discuss these situations.”

In emergency care settings, doctors have noted several unusual indicators reflecting the impact of immigration enforcement. For instance, Dr. Amy Zidan, an emergency physician in Atlanta, reported a more than 60% decline in requests for Spanish interpretation in her hospital’s emergency department from January to February.

Theresa Cheng, an ER physician at Zuckerberg San Francisco General Hospital, recounted an incident where one of her residents cared for an immigrant patient who had sustained multiple facial fractures from an assault but hadn’t sought care for over two weeks. “There is an overwhelming sense of fear,” Dr. Cheng stated.

In late January, Dr. Cheng treated a patient with severely untreated diabetes. The undocumented woman shared her terror and had been waiting for assistance. Tragically, she passed away that same day.

Dr. Carolina Miranda, a family physician in the Bronx, discussed a patient granted legal asylum, yet fearing ICE, who missed an appointment regarding a potential brain tumor.

Similar delays and cancellations have been observed among pregnant women and new mothers nationwide. Dr. Caitlyn Bernard, an obstetrician in Indiana, noted a patient who skipped a postnatal visit, indicating she no longer felt safe leaving her house. Staff on the obstetrics floor of a San Diego hospital reported a significant drop in immigrant women experiencing acute pregnancy-related issues following the administration change.

“These women undeniably still exist,” a doctor, choosing to remain anonymous due to institutional restrictions on public statements, expressed. “I fear this will drive up maternal mortality rates over time.”

Many children of immigrant parents who skip appointments or leave prescriptions unfilled are American citizens. In mixed-status families, parents facing deportation often hesitate to bring their children to clinics or pharmacies.

Pediatricians serving underserved populations in Central Coast California reported a 30% increase in missed child appointments. Many families who sought professional care for their children, including evaluations for speech therapy and autism, cited fear as a barrier, with some wishing to remain anonymous due to the sensitive nature of their situations.

Dr. Tania Caballero, a pediatrician at Johns Hopkins, has encountered parents reluctant to visit emergency rooms, including those with children suffering from chronic conditions such as cerebral palsy, asthma, and diabetes.

“I tell my patients, ‘I cannot control what happens outside of my clinic. I can’t ensure against an ICE visit, but you know me, and I possess the resources to help you navigate this journey together,'” she explained.

Some parents facing dire circumstances, like those of children undergoing cancer treatment, believed their child’s medical conditions might shield them. They sought letters from pediatricians outlining their child’s medical needs, hoping this information would convince immigration authorities to allow them to remain in the U.S. for survival.

Dr. Lisa Gwyn, a pediatrician in South Florida, reported alarming drops in patient attendance as families from the Caribbean and South America miss essential pediatric vaccinations needed to prevent illnesses like measles, pneumonia, and whooping cough.

Dr. Gwyn also expressed concern for children who have endured significant trauma before arriving in the U.S. and who are not connected with social workers or psychologists for needed support.

“Imagine a child living in a home filled with fear. They came to this country hoping to find safety, only to feel afraid again,” she said. “We understand that prolonged stress negatively impacts health. Children who are stressed perform poorly in school and often battle mental health issues, including anxiety and depression.”

Some medical facilities have stated they will comply with immigration authorities. NYU Langone has issued warnings to employees cautioning against attempting to shield undocumented patients. However, many other health centers and organizations are finding ways to protect their patients by displaying “Know Your Rights” information and advising staff not to log immigration status in patients’ medical records.

Last week, the New England Journal of Medicine published an article detailing how physicians continue to provide healthcare while legally distancing themselves from ICE requests.

The St. John’s Clinic Network in Los Angeles recently instituted an ambitious home visit initiative where doctors, nurses, and medical assistants conduct examinations and deliver medication, working to inform all undocumented patients of this service.

The New York Regional Hospital Association proposed designating a “hospital contact” to quickly guide law enforcement to private offices, emphasizing the necessity of viewing signed warrants.

In the emergency department at University Hospital, a safety-net facility in Newark, staff distribute cards in Spanish and other languages to remind patients of their rights, stating, “You have the right to refuse consent to searches of yourself, your car, or your home.”

Yet, fear remains palpable. Dr. Annaly M. Baker, an emergency physician, recounted witnessing a young woman who had been beaten unconscious waiting for hours to receive care.

Dr. Baker also attended to a minor who had been stabbed but required parental consent for treatment. The boy was reluctant to provide details, fearing that his parents might be caught in immigration enforcement.

What troubles Dr. Baker most is the number of people who never seek treatment at all.

“The tragic message to these individuals is to remain hidden, and I hope you don’t die,” she remarked.

Sarah Cliff contributed to this report.

Source: www.nytimes.com

Concerns Emerged from Foresight AI Utilizing 57 Million NHS Medical Records

The Foresight AI Model employs information derived from records of hospitals and family practitioners across the UK

Hannah McKay/Reuters/Bloomberg via Getty Images

The developers assert that an AI model trained with medical records of 57 million individuals through the UK’s National Health Service (NHS) could eventually assist physicians in anticipating illness and hospitalization trends. Nonetheless, other academics express significant concerns over privacy and data protection associated with the extensive utilization of health data, acknowledging that even AI developers are unable to ensure the absolute protection of sensitive patient information.

This model, branded as “Foresight,” was initially created in 2023. Its first iteration leveraged OpenAI’s GPT-3, the prominent language model (LLM) that powered the original ChatGPT, using 1.5 million authentic patient records from two hospitals in London.

Recently, Chris Tomlinson from University College London and his team broadened their objectives, claiming to develop the world’s first “national generative AI model for health data” with significant diversity.

Foresight utilizes Meta’s open-source LLM, LLAMA 2, leveraging eight distinct datasets of medical information routinely collected by the NHS between November 2018 and December 2023, including outpatient appointments, hospital visits, vaccination records, and other relevant documents.

Tomlinson notes that his team has not disclosed any performance metrics for Foresight, as it is still undergoing evaluation. However, he believes that its potential extends to various applications, including personalized diagnoses and forecasting broader health trends such as hospital admissions and heart conditions. “The true promise of Foresight lies in its capacity to facilitate timely interventions and predict complications, paving the way for large-scale preventive healthcare,” he stated at a press conference on May 6.

While the foreseeable advantages remain unsupported, the ethical implications of utilizing medical records for AI learning at this magnitude continue to raise alarms. Scholars argue that all medical records undergo a ‘degeneration’ process before integration into AI training, yet the risk of re-identifying these records through data patterns is well-established, especially in expansive datasets.

“Creating a robust generative AI model that respects patient privacy presents ongoing scientific challenges,” stated Luc Rocher at Oxford University. “The immense detail of data advantageous for AI complicates the anonymization process. Such models must operate under stringent NHS governance to ensure secure usage.”

“The data inputted into the model is identifiable, so direct identifiers will be eliminated,” remarked Michael Chapman, who oversees the data fueling Foresight, in a speech at NHS Digital. However, he acknowledged the perpetual risk of re-identification.

To mitigate this risk, Chapman explained that AI functions within a specially created “secure” NHS data environment, guaranteeing that information remains protected and accessible solely to authorized researchers. Amazon Web Services and Databricks provide the “computational infrastructure,” yet they do not have access to the actual data, according to Tomlinson.

Regarding the potential to expose sensitive information, Yves-Alexandre de Montjoye from Imperial College London suggests evaluating whether a model can retain the information it encounters during training. When asked by New Scientist whether Foresight has undergone such testing, Tomlinson indicated that it has not, but they are contemplating future assessments.

Employing such an extensive dataset without engaging the public regarding data usage may erode trust, cautions Caroline Green at Oxford University. “Even anonymized data raises ethical concerns, as individuals often wish to manage their data and understand its trajectory.”

Nevertheless, prevailing regulations offer little leeway for individuals to opt out of the data utilized by Foresight. All information incorporated into the model emanates from NHS datasets gathered on a national scale and remains “identified.” An NHS England representative stated that the existing opt-out provisions do not apply, asserting that individuals not wishing to share their family doctor data will not contribute to the model.

As per the General Data Protection Regulation (GDPR), individuals should retain the option to withdraw their consent concerning personal data usage. However, training methods involving LLMs like Foresight make it impossible to eliminate a single record from an AI tool. An NHS England spokesperson commented, “The GDPR does not pertain since the data utilized to train the model is anonymized, and therefore we do not engage with personal data.”

While the complexity of GDPR concerning the training of LLMs presents novel legal issues, the UK Information Commissioner’s Office indicates that “identified” data should not be viewed as equivalent to anonymous data. “This perspective arises because UK data protection laws lack a definition for the term, which can lead to misunderstanding,” the office emphasizes.

Tomlinson explains that the legal situation is compounded as Foresight is only engaged in studies pertaining to Covid-19. This means that exceptions to data protection laws instituted during the pandemic remain applicable, points out Sam Smith from Medconfidential, a UK data privacy advocacy group. “This Covid-specific AI likely harbors patient data, but such information cannot be extracted from the research environment,” he asserts. “Patients should maintain control over their data usage.”

Ultimately, the conflicting rights and responsibilities surrounding the utilization of medical data in AI developments remain ambiguous. “In the realm of AI innovation, ethical considerations are often overshadowed, prompting a reevaluation beyond merely initial parameters,” states Green. “Human ethics must serve as the foundational element, followed by technological advancements.”

The article was updated on May 7, 2025

Corrections regarding the comments made by the NHS England spokesperson were duly noted.

Topics:

Source: www.newscientist.com

Medical Journals Face “Harassment” Allegations from the Department of Justice

At least three medical journals have received correspondence from the U.S. Department of Justice, raising questions about their editing practices and urging them to maintain their independence.

The Lancet, a prominent British medical journal that did not receive one of these letters, published an editorial condemning the inquiries as “harassment” and threats, stating that American science has been “harshly detached” under the Trump administration.

Recently, Interim U.S. Attorney Ed Martin for the District of Columbia contacted the Chest Journal, which focuses on chest medicine, suggesting it has a partisan bias. The letter included inquiries about measures needed to combat misinformation, incorporating various perspectives.

This communication sparked outrage from the First Amendment group and several scientists, who expressed concerns that such law enforcement actions could undermine academic freedom and free speech. The letter encouraged the journal to clarify that its publisher, the American College of Chest Physicians, “supports the journal’s editorial independence.”

This week, the New England Journal of Medicine confirmed to NBC News that it had also received a similar letter from an interim U.S. attorney.

In a response shared with NBC News, the journal’s editor-in-chief, Dr. Eric Rubin, defended its rights as an independent publisher, emphasizing their strict peer review and editing process to ensure the objectivity and reliability of the research published. “We uphold their First Amendment rights to editorial independence and free expression in medical journals,” Rubin stated. “The journal remains committed to fostering academic scientific dialogue and supporting authors, readers, and patients.”

The third journal, Obstetrics and Gynecology, also confirmed receiving a letter from Martin.

“Obstetrics and Gynecology editorially operates independently from ACOG, although we share the mission of improving outcomes for individuals needing obstetric and gynecological care,” a representative from the American University of Obstetrics and Gynecology remarked in an emailed statement. “We take pride in our journal’s focus on scientific data and patient-centered, respectful, evidence-based care.”

MedPage Today, a medical industry news outlet, first reported the existence of a new DOJ letter.

The DC office of the Department of Justice did not respond to NBC News’ request for comment.

Meanwhile, The Lancet, which has been publishing for over 200 years, adopted a more assertive tone. In a scathing editorial in solidarity with other journals, it described the letter from the Justice Department as “harassment” within the broader context of the Trump administration’s “systematic dismantling of U.S. scientific infrastructure.”

“This is a blatant attempt to intimidate journals and infringe upon their rights to independent editorial oversight. The Lancet and other medical journals are being targeted by the Trump administration,” the editor remarked. “Medical journals should not expect to be spared from the administration’s attacks on science, as institutions like the NIH, CDC, and academic medical centers are also being affected.”

Scientific journals are essential for disseminating new discoveries and insights among colleagues. Some journals are managed by specialized experts, while others are published by organizations with a focus on science. A reputable journal ensures that research undergoes thorough peer review, where external experts appraise it for errors and research quality.

The scrutiny of scientific journals occurs as the Trump administration has faced reductions in funding and staffing.

NBC News inquired with several major scientific and medical journal groups regarding whether they received similar letters from the Department of Justice.

Representatives from Science, Elsevier, Nature, and JAMA, the medical journal of the American Medical Association, did not reply to requests for comment.

Wiley Publishing Company acknowledged receipt of the letter from an interim U.S. attorney but did not provide further details.

“We remain committed to the highest standards of editorial independence, academic rigor, and publication ethics,” a Wiley spokesperson stated. “Our journal evaluates submissions based on their scientific merits and collaborates closely with social partners to ensure a wider perspective contributes to the advancement of knowledge.”

Source: www.nbcnews.com

Federal prosecutors seek major medical journals in response to ambiguous threat

Federal prosecutors in Washington reached out to the New England Journal of Medicine with unsubstantiated inquiries that implied the journal, considered one of the most prestigious in the world, may be biased towards certain viewpoints and influenced by external pressures.

NEJM editor Dr. Eric Rubin described the letter as “blatantly threatening” in an interview with the New York Times.

Republican activist Edward Martin Jr., serving as interim U.S. attorney in Washington, sent similar letters to at least three journals. Martin has faced criticism for using his position to target opponents of the administration.

The letter accused the journal of taking sides in scientific debates and posed accusatory questions about bias and the selection of research articles.

Will they consider submissions from scientists with differing perspectives? How will they handle authors whose work they have published that may have misled readers? Are they transparent about the influence of supporters, funders, advertisers, etc.?

This news about the letter to NEJM was previously reported by Stat and Health News Outlet.

Martin also raised questions about the role of the National Institutes of Health, which funds some of the research published by the journal, and its involvement in the development of submitted articles.

Amanda Shanor, a First Amendment expert at the University of Pennsylvania, emphasized that information published in reputable medical journals like NEJM is widely protected by the Constitution.

She explained that journals have the same rights as newspapers in most cases, with the Constitution providing the strongest legal protection.

“There is no legal basis to suggest that medical journals are not afforded the strictest First Amendment protections,” she stated. “It seems to be an attempt to instill a sense of fear and censorship that impacts people’s freedom of expression. This raises constitutional concerns.”

It is unclear how many journals received these letters or the criteria Martin used to target publications. The U.S. Attorney’s Office in Washington did not respond to requests for comment.

Our role is to assess and evaluate science in an impartial manner,” Dr. Rubin stated. The questions raised seem to insinuate biases in our operations – it is quite vague This introduces a threatening element. ”

Former editor of Science magazine, Jeremy Berg, believed the letter was an attempt to coerce journals into publishing papers aligning with the administration’s views on climate change and vaccines, even if the research quality is lacking.

National Health Secretary Robert F. Kennedy Jr. mentioned in an interview with the “Dr. Hyman Show” podcast last year that NEJM was involved in disseminating misinformation and distorting scientific facts.

Department of Health and Human Services spokesman Andrew Nixon declined to comment on Kennedy’s involvement in the letter.

Kennedy expressed his intention to possibly take legal action against medical journals under the Federal Anti-Corruption Act.

“I plan to file a lawsuit against you under general tort laws and the Assault Act,” he stated. “Unless you have a plan to demonstrate how you will begin publishing genuine scientific work, I will find a way to pursue legal action against you.”

Dr. Jay Bhattacharya, the new head of NIH, has criticized mainstream science journals and recently co-founded a new journal that offers alternative perspectives on Covid.

The UK-based Lancet showed support by editing Editor Skas’s response, calling it “an obvious attempt to intimidate and stifle editorial independence.”

“American science and medicine are being closely watched worldwide,” the editor stated.

One of Martin’s letters was directed at the journal Chest, a publication focused on technical research in areas like lung cancer and pneumonia. It was reported by The New York Times that at least two other publishers received similar letters.

These publishers chose not to speak publicly for fear of repercussions from the Trump administration.

Dr. Rubin also expressed concerns about potential political backlash. Science journals often rely on public funding indirectly, with universities using federal grants to pay for subscriptions.

“Are we concerned? Absolutely,” he said. “But we are committed to doing what is right.”

Martin gave the magazines until May 2nd to respond to his inquiries. NEJM has already issued a statement refuting the accusations made against their journal.

“We maintain strict peer review and editing processes to ensure the integrity and trustworthiness of published research,” the statement affirmed. “We uphold the editorial independence of medical journals and their inherent right to protect their freedom of expression.”

This is not NEJM’s first run-in with the Trump administration.

In 2020, the Journal dismissed an editor who criticized the president’s pandemic response. This marked the first time in its 208-year history that the Journal took a stance on a political figure.

Dr. Rubin speculated that Martin’s letter may be related to this editorial decision. While the Journal Chest did not publish on Trump’s first term, the connection was noted.

Source: www.nytimes.com

What lessons can we learn from the remarkable medical expertise of wildlife?

20 years ago Jaap de Roode made discoveries that changed his scientific career. While studying the ecology and evolution of parasites and their hosts, he came across something truly surprising. The butterfly of the monarch, whom he was studying, appeared to be using the medicinal properties of the plant to treat itself and its offspring.

At the time, the notion that insects might be able to receive self-medicine appeared to be far away. Currently, De Roode is a world expert in the fast-growing field of animal medicines, and has his own lab at Emory University in Atlanta, Georgia. He spoke New Scientist about his work, his new book, Naturopathic Doctor: How Ants, Apes and Other Animals Heal themselves, and his belief that animals have medical knowledge that can be used to improve our own health.

Self-medical behavior of chimpanzees and wool bear caterpillars (bottom) is also being studied

Michael a Huffman

Graham Lawton: How did this realm go?

Jaap de Roode: It started out as a random observation while working in Tanzania in the 1980s. Kyoto University’s Michael Huffman was working with national park ranger Mohandi Seyf Kalunde to investigate the role of older chimpanzees in society. While tracking down something called Chausiku, they realized she had retreated, and she was taking a nap during the day and had diarrhea. They saw her go to the plant called Vernonia also known as bitter leaves. She stripped off the bark and began sucking on the pith. This is not usually part of their diet. Seifu, a traditional healer, told Huffman that he was using it as…

Source: www.newscientist.com

Long Covid remains a medical enigma after five years: new discoveries from scientists

When her school closed in March 2020, Baltimore English teacher Chimere Sweeney thought that once the US got the new SARS-COV-2 virus, she would return to her students. But “There was another plan in life,” she said when she quickly got Covid and never recovered.

Initially, Sweeney developed only muscle pain. By the second week she began having panic attacks, blurry vision, constipation and partial hearing loss. Half of her face freezes “like concrete.” She forgot her phone number and address and stuttered. Within a month of contracting, she lost 30 pounds.

“In two weeks, I was told I would be better,” said Sweeney, now 42. “But my two weeks didn't come.”

Almost five years later, she still suffers from severe whole body pain, insomnia, depression, painful rash and boiling, uncontrollable urination, short-term memory loss and irregular periods.

“I'm a healthy 37-year-old woman and I might have had to pop allergy pills many times, but I took 10-12 medications per day to control almost every system in my body,” Sweeney said.

The World Health Organization characterized Covid as a pandemic on March 11, 2020, so scientists don&#39t fully understand why some people develop chronic diseases and disordered conditions after their first virus infection. The US may have come throughout the winter after the first pandemic without a massive surge in cases, but each infection is at risk of developing a long community. Some scientists are looking for a new type of clinical trial designed for the longest and most debilitating covid patients.

Long covid is known to be the cause Over 200 different symptoms There are no approved tests or recommended treatments in almost 12 organ systems, including those of the heart, lungs, kidneys, brain, eyes and skin. Research shows long covid It&#39s more common for middle-aged people, especially women and those with weakened immune systems, but anyone who catches the virus can get it.

The Centers for Disease Control and Prevention estimates that there is one in every 20 adults in the United States, or about 14 million. Living with a long covid. Other data shows that 5.8 million children It may be affected by the condition as well. However, experts say these numbers are likely to be underestimated as there is no official surveillance system in place.

Billion Dollar Research Initiative Called Recover Started by the National Institutes of Health, finding the causes and potential treatments of covid, I've reached that promisesays scientists and patient advocates.

Meanwhile, experts fear that extreme cuts in federal spending by the Trump administration could be possible It undermines long Covid's research effortswhich could further delay the discovery of treatment. Last month, President Donald Trump ended his secretary as a health and welfare secretary Advisory Committee on Long Covid.

This indefinite dye microscope image, available to the US National Institutes of Health in February 2020, shows the novel coronavirus SARS-COV-2, shown in yellow, emerges from the cell surface and is cultured in laboratory culture.niaid-rml via AP file

W. Medical Director, UT Health Austin. Dr. Michael Broad Post-Covid-19 Program In Texas, “We build boats while we're at the sea and we're trying to understand together. [with patients] …But we need to build on the progress we have already made. ”

“We are not offering answers that are worthy of the public health crisis we are facing,” he said.

Causes of long covids

SARS-COV-2, which causes Covid, is not the only virus that causes prolonged symptoms. Another condition called myalgia encephalomyelitis/chronic fatigue syndrome (ME/CFS) shares many similarities with the long community; Caused by infection Among other things, Epstein Barr, influenza, and water cell-zoster virus.

Brode said Covid is unique because it is more likely to cause chronic disease than other pathogens. It has not yet been determined why it could lead to long-term symptoms. Experts have come to several theories so far.

One idea is that Virus remains hidden in different tissues Broad said after the infection subsided. These viral particles continue to thrust and stimulate the immune system in ways that cause long covid symptoms.

Another potential cause is Reactivation of other virusessitting in a dormant state of people's bodies, such as EBV and HIV.

Dr. Igor Coralnik, co-director of Northwest Medicine's Comprehensive COVID-19 Centre, said Covid could also trick the immune system into producing antibodies that attack people's own healthy organs and tissues.

Some evidence shows covid It affects the inner layer of blood vesselswhich leads to the formation of small clots and helps explain the symptoms, such as irregular heartbeat and heart failure, that some long-term community patients experience, Koralnik said.

It is unclear whether one or a combination of these factors will cause long covid, experts say. But the evidence suggests that they are all linked to an increase in inflammation in the body, Coralnik said, it's yours The risk of long covid increases with each covid infection.

“It's like a river that's over a dam,” Coralnik said. “The more episodes of Covid, the higher the river levels will go to where it is overflowing, and there will be a long flood of COVID symptoms.”

Diagnosis of long covids can be complicated

There are diagnostic tools to check for long covid symptoms, such as MRI scans for heart abnormalities. There are no tests that can diagnose the condition Or distinguish it from similar diseases, the CDC says.

As a result, people need to stay away from work, school or other responsibilities and endure numerous clinical tests and scans that are not only expensive, but also stressful and time-consuming. This is a broad exclusion process that prevents people from getting the help they need, Broad said.

Eye, intestine, and immune system clue

The current challenge is to find one or more biomarkers of genes, proteins, or other substances associated with a particular condition that will help diagnose long covid.

a Recover your research Released last year, routine lab tests, including 25 standard blood and urine tests, showed little difference in biomarkers, with or without previous symbiotic infections. Researchers concluded that these tests may not be useful in the diagnosis of long-term COVID.

Koralnik and his team recently discovered that people with long covids are reducing blood flow in small blood vessels in the retina. This reduced flow is thought to reduce blood circulation in and around the brain, and the small organelles called mitochondria, which convert oxygen into energy, are described as “toxic.”

This theory can explain why many people with long covid experience cognitive problems, fatigue and exercise intolerance, Coralnik said. Overall, the findings published in the Journal of Imaging in February are The retina can become a long covid biomarker.

Other studies suggest that biomarkers may be present in the gut and immune system, but Brode noted that these early findings are based on small groups of people and should be considered in salt grains.

As useful as diagnostic tests, experts say that for those with prolonged symptoms, some experts should not slow scientists in searching for long covid treatments.

Julia Moore Vogel, senior program director at Scripps Research, and Patient-led research cooperation Regarding long covid, he said that other conditions like migraines do not have reliable biomarkers or tests to confirm the diagnosis. Several drugs have been approved To handle it.

“I think we'll get there,” said Vogel, a long-distance runner before developing the long-time Covid in 2020. “But I personally don't think it should contain anything.”

Unfortunate advances in long covid treatments

The Food and Drug Administration has not approved treatments, particularly for long covids. Experts are not sure if they'll get it anytime soon.

“When I first got sick, I was OK, I had to survive for just three to five years. At least, I think I have options as I have decent symptom management trial data. But we've made little progress in treatment,” Vogel said. “There are currently promising research beginning, but it's not close to the amount that should be burdened by the disease.”

Most clinical trials test whether medications used to treat other conditions are useful for long-term COVID. For example, researchers at the University of British Columbia Low-dose naltrexone – Approved drugs for opioid and alcohol use disorders. The drug is thought to have anti-inflammatory and pain relief properties and is used off-label in people with fibromyalgia and ME/CFS, making it potential as a long-term symbiotic treatment.

Other drugs Barishinibapproved for treating rheumatoid arthritis and acute charlation, and Temelimabuexperimental drugs often administered to people with multiple sclerosis have also been investigated as potential long covid treatments.

Instead of a particular treatment, people with long covids must balance rest and activity in a strategy called pacing and undergo physical and cognitive behavioral therapy for further support. Many people will often rely on several drugs, including antiviral Paxlovid, to treat symptoms.

But realistically, “we may not actually have one silver bullet treatment,” says Alison Cohen, an epidemiologist at the University of California, San Francisco, who coexisted for three years for a long time. Cohen said that long covid will take a “multi-faceted approach” to take a “multi-faceted approach” in a very diverse way.

What will you do in the future for recovery?

As long as SARS-COV-2 continues to spread, everyone is at risk of a long Covid, Cohen said. And now, evidence shows that recovery from the condition is rare. A survey released last month found it Only about 6% of people with long covid recover According to Cohen, two years later. Covid vaccinations were associated with better long-term recovery, especially among those who won booster shots.

People who improve are experiencing many “ups and downs,” Coralnik said. “You need to expect a lot of collisions on the road.”

“Living with a long Covid is tiring,” Cohen said. “So for everyone who doesn&#39t live with it, it&#39s important to think about what we can do to support those who have them.”

In the meantime, clinical trials must be designed to accommodate and include the patients they intend, Vogel said. Many people are tied to their homes and beds and cannot travel due to the risk of multiple in-person visits or flare-ups of symptoms, she added. “There are too many things you can&#39t know until you put them on the table,” she said.

Although we don&#39t know when a long community community finally gets the answers and security they need, Vogel keeps her head high.

“We know we can do that. We are confident that a well-designed and well-tested exam will at least improve the quality of life. “But I can&#39t think of any other way. I can&#39t accept that this is for my life.”

Source: www.nbcnews.com

Accidental Broadcast of NASA Astronaut Medical Training

NASA had to reassure the public that there was no emergency on the International Space Station after audio from a medical training drill was mistakenly played during a livestream on Wednesday night.

The regularly scheduled livestream was interrupted at 6:28pm ET by an unidentified speaker, apparently a flight surgeon, communicating with the ISS crew about what to do for the commander, who was suffering from severe pressure illness.

The speaker advised crew members to “check the pulse again” before placing the injured astronaut in a spacesuit filled with pure oxygen. She said any treatment was “the best treatment” and better than nothing.

“Unfortunately, Commander's prognosis is relatively uncertain,” she said.

“I'm concerned that there are people with severe DCS,” she said. [decompression sickness] He “hits” and tells the crew to get him suited up as quickly as possible.

She mentions that there is a hospital in San Fernando, Spain, with a hyperbaric treatment facility, apparently implying that she would order an emergency evacuation of the space station.

But after stirring up fear among space enthusiasts listening in, NASA revealed that this scenario wasn't real: All crew members aboard the ISS were safely asleep at the time.

NASA said there was “no emergency on board the International Space Station.”

“At approximately 5:28 p.m. CDT, audio was broadcast on NASA's livestream from a ground-based simulated audio channel indicating the crew member was experiencing symptoms associated with decompression sickness,” NASA said in a statement. X's message.

“The audio was inadvertently transmitted from an ongoing simulation in which crew and ground teams were training for various scenarios in space and is not related to an actual emergency,” NASA said in a statement.

“The International Space Station crew was asleep at the time. All crew members are healthy and safe, and tomorrow's spacewalk will begin as scheduled at 8 a.m. EDT,” it added.

The emergency training came after two astronauts aboard Boeing's Starliner spacecraft successfully docked with the ISS last week.

Source: www.nbcnews.com

Medical records of astronauts uncover health risks of space travel

Astronauts Robert L. Curbeam Jr. (left) and Christer Fugelsang aboard the International Space Station

National Aeronautics and Space Administration (NASA)

How spaceflight affects astronauts' health may be better understood thanks to the creation of the first “space-omics” biobank, a collection of thousands of blood and tissue samples and medical information taken on multiple space missions.

These include missions to the International Space Station as well as SpaceX's Inspiration 4, the first private spaceflight to send four non-government-trained astronauts into space for three days in 2021.

The resource, called the Space Omics and Medical Atlas (SOMA), contains detailed medical data, collectively known as biomarkers, such as DNA damage and changes in people's gene activity and immune system function.

Space flight is known to pose certain health risks. For example, astronauts experience reduced bone density and muscle mass due to weightlessness, and high levels of radiation in space can damage cells and DNA, causing a variety of health effects on the body. Astronauts are more likely to develop heart disease Later years and Some people have experienced a decrease in vision After going into space.

By consistently collecting astronauts' medical data through the SOMA biobank, researchers may be able to better understand these changes and develop ways to mitigate them, the researchers say. Christopher Mason He is a professor at Weill Cornell Medicine in New York and helped establish the biobank.

“Biomarkers don't necessarily translate into anything clinically meaningful, but they're a good way to understand how this unique environment is affecting us.” Damien Bailey The researchers are from the University of South Wales in the UK, but were not involved in the study.

One of the findings from the Inspiration 4 mission was that although astronauts experienced changes in numerous biomarkers, most measurements returned to normal within a few months of returning to Earth.

This suggests that sending private citizens into space poses no greater health risks than sending professional astronauts, Mason said. “Instead of training them for decades, we can start opening up space to more people.”

Results from Inspiration 4, which had two men and two women on board, also suggested that changes in gene activity returned to normal more quickly in women. This may be because women's bodies have to be able to cope with the possibility of pregnancy, Mason says. “Being able to withstand big changes in physiology and fluid dynamics could be great for managing pregnancy, but it could also help manage the stresses of spaceflight.”

Timothy Etheridge A researcher from the University of Exeter in the UK says it would be beneficial to have a common resource that researchers around the world can use. “We need a consistent approach to collecting samples,” he says.

Thomas Smith The researcher, from King's College London, says understanding the health effects of spaceflight will become even more important if longer-term missions take place, such as trips to Mars. “Anything that leads to longer-term missions makes it even more important to know what's going on and, ideally, to be able to address it,” he says.

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Source: www.newscientist.com

Top 10 Groundbreaking Medical Advancements: Pure Moments of Eureka captured in Photos

The history of science is filled with moments of discovery, those “Eureka” moments when a theory is proven or a breakthrough is achieved. The latest image competition at Great Ormond Street Hospital, titled ‘A Moment of Discovery’, celebrates these breakthroughs.

Staff from Great Ormond Street Children’s Hospital NHS Foundation Trust (GOSH) and its partners have submitted images capturing significant milestones in research. The public voted on the three most popular images shortlisted by a panel of experts via social media.

The shortlisted images range from colorful micrographs to cartoon illustrations, offering a glimpse into the research conducted at GOSH. It is hoped that this research will lead to new treatments for rare and complex conditions, transforming the lives of children and young people with serious illnesses.

The winning image, taken by PhD student Giada Benedetti at the Zayed Pediatric Rare Disease Research Center (ZCR), shows exploding intestinal organoids revealing their inner workings.

Organoids are small three-dimensional tissue cultures derived from stem cells that can mimic different organs like the heart and liver in the human body.

In honor of Rare Disease Day on February 29, all winning and shortlisted images will be displayed at an event at the Zayed Pediatric Rare Disease Research Center.

Selected as a finalist – my lungs are on fire

These lung “mini-organs,” or organoids, were grown from stem cells to replicate the complexity of lungs. The image showcases cell nuclei in blue, cell membranes in red, and moving hair-like structures called cilia in yellow/orange. Photo courtesy of Giuseppe Cala at GOSH.

Shortlist – Active Glial Cells

The image showcases nerve helper cells, known as glial cells, with long fibrous structures that transport nutrients and oxygen to surrounding nerve cells. Photo courtesy of Lucien Bonfante at GOSH.

Finalist – Light of Life

The image shows the spinal cord of a zebrafish embryo with different neurons generated through asymmetric division. Photo courtesy of Atachapon Theppichaiyanond at GOSH.

Source: www.sciencefocus.com

Non-military drones could be used to deliver medical supplies under UK travel monitoring program

Britain’s air travel watchdog has proposed the use of drones to deliver medical supplies and inspect railways, power lines, and roads. The UK Civil Aviation Authority (CAA) has published a consultation paper outlining the proposals, which would allow pilots to safely fly drones out of sight.

While some drones have been flying beyond visual lines in the UK for test flights, the new proposals would enable drones to operate out of sight by flying at a lower height and closer to buildings and infrastructure, reducing the risk of other aircraft traffic.

Kevin Woolsey, head of remotely piloted aircraft systems at the CAA, stated that the proposed concept would open the door to the next stage of drone flying in the UK, potentially allowing for beyond visual line of sight operations and online shopping delivery by drone.

The CAA intends to allow drones to be used on private land without a permit, as long as they do not fly higher than 15 meters. Industries involved in infrastructure inspections, such as railways, power lines, and roads, as well as farmers and field security, are expected to benefit from these proposals.

The consultation forms part of the UK’s future flight plans, which aim to enable drones to safely share more of the sky with other airspace users. The CAA will run the consultation for six weeks and provide further details on its website.

The proposals also include allowing drones to fly in “atypical air environments,” which are areas with reduced conventional aircraft traffic due to proximity to buildings and ground infrastructure. The CAA acknowledges the risks associated with operating in such airspace and will work to mitigate these risks with relevant approvals from operating companies.

Source: www.theguardian.com

Understanding the sensation of dying: Insights from medical professionals

Similar to childbirth, death is a bodily process that progresses through stages and is recognizable. The speed of the process varies from person to person, and medical support may be necessary to ensure a safe and comfortable experience.

As death nears, most people lose interest in eating and drinking, which is normal. Even if they are unable to manage full meals, a small taste may still be welcomed.

Dying individuals typically experience a lack of energy, similar to the extreme fatigue associated with severe illness or surgery recovery. While sleep normally recharges energy, it gradually diminishes as the body weakens towards death.

Waking hours decrease, and periods of unconsciousness become more frequent. People report feeling like they were peacefully asleep during these periods of unconsciousness.

If the dying person relies on regular medications, it may be necessary to switch to medications that do not require swallowing. Skin patches, syringe pumps, and suppositories can be used, as unconsciousness is usually caused by the dying process, not medication.

What happens in your last moments

As death progresses, the heartbeat slows, blood pressure drops, the skin cools, and the nails dull. Restlessness, confusion, and periods of deepening unconsciousness may occur.

There is no proven method to investigate what people experience near death, but recent research suggests that the unconscious brain responds to noise in the room. Breathing becomes automatic and may involve heavy, noisy breaths or breathing through saliva in the back of the throat without signs of distress.

Breathing cycles from deep to shallow, fast to slow, until it becomes slow and very shallow, eventually pausing and stopping altogether due to lack of oxygen.

Understanding common patterns of death and its stages can help companions feel less fearful and manage symptoms. Seeking medical attention when necessary is important. For more information, you can watch the BBC short film about death: BBC short film about death.

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Source: www.sciencefocus.com