A virtual drone was steered through an obstacle course by imagining moving a finger.
Wilsey et al.
A paralyzed man with electrodes implanted in his brain can pilot a virtual drone through an obstacle course just by imagining moving his fingers. His brain signals are interpreted by an AI model and used to control a simulated drone.
Research on brain-computer interfaces (BCI) has made great progress in recent years, allowing people with paralysis to write speech on a computer by precisely controlling a mouse cursor or imagining writing words with a pen. It became. However, so far it has not yet shown much promise in complex applications with multiple inputs.
now, Matthew Wilsey Researchers at the University of Michigan created an algorithm that allows users to trigger four discrete signals by imagining moving their fingers and thumbs.
The anonymous man who tried the technique is a quadriplegic due to a spinal cord injury. He was already fitted with Blackrock Neurotech's BCI, which consists of 192 electrodes implanted in the area of the brain that controls hand movements.
An AI model was used to map the complex neural signals received by the electrodes onto the user's thoughts. Participants learned how to think about moving the first two fingers of one hand to generate electrical signals that can be made stronger or weaker. Another signal was generated by the next two fingers, and another two by the thumb.
These are enough to allow the user to control the virtual drone with just their head, and with practice they will be able to expertly maneuver it through obstacle courses. Wilsey said the experiment could have been done using a real drone, but was done virtually for simplicity and safety.
“The goal of building a quadcopter was largely shared by our lab and the participants,” Wilsey says. “For him, it was a kind of dream come true that he thought was lost after he got injured. He had a passion and a dream to fly. He felt so empowered and capable. He instructed us to take a video and send it to a friend.
Although the results are impressive, Willsey says there is still much work to be done before BCIs can be reliably used for complex tasks. First, AI is required to interpret the signals from the electrodes, but this depends on individual training for each user. Second, this training must be repeated over time as function declines. This could be due to slight misalignment of the electrodes in the brain or changes in the brain itself.
As individuals age, their brains may experience difficulties in learning and decision-making due to a decrease in brain cells and cognitive function. However, neuroscientists have found that the brain can rewire connections to compensate for age-related cognitive decline through a process known as compensatory scaffolding. This involves forming new connections in the brain, strengthening existing ones, and even generating new brain cells. Yet, the specifics of how these new connections operate and interact, as well as their limitations, remain unclear.
Research conducted by Leonardo Bonetti and colleagues indicates that older individuals may exhibit more compensatory scaffolding and less unilateral brain activity compared to younger individuals when processing auditory information like music. Previous studies have shown that certain brain areas involved in memory and task processing decline faster in aging individuals, prompting Bonetti’s team to investigate how age impacts the brain’s response to compensatory scaffolding during music processing.
To test their hypothesis, Bonetti and his team studied brain activity in 37 young adults (aged 18-25) and 39 older adults (aged 60 and above) as they listened to music. Using magnetoencephalography and magnetic resonance imaging devices, the researchers mapped brain activity in specific regions responsible for sound processing and decision-making, such as the temporal lobe, frontal lobe, and hippocampus.
During the study, participants were asked to memorize a musical sequence and distinguish between the original version and modified versions with altered notes. Older participants showed less brain activity in most regions compared to younger participants, except for the left auditory cortex. This increased activity in the left auditory cortex suggested that the aging brain can reorganize and maintain function in certain areas, despite decreased activity in memory-related regions.
Notably, younger participants displayed more brain activity in memory and working memory areas, enabling them to detect modified musical sequences more effectively than older participants. The study also revealed that individuals with strong working memory were better at recognizing modified sequences, regardless of age group.
Overall, the research highlights that parts of the brain linked to memory and cognitive function may decline with age, but healthy aging can trigger brain reorganization to mitigate functional decline. Bonetti’s findings challenge previous notions that aging does not impact brain pathways associated with memory, decision-making, and other executive functions.
The International Classification of Diseases (ICD) is a text created by the World Health Organization that summarizes all medical problems recognized by the organization.
When it comes to the latest version, ICD-11was created and added the category of addictive behaviors to the section on addictive disorders. It is now medically accepted that people can become addicted not only to substances but also to certain activities. The most important of these behaviors is gambling.
Gambling addiction is definitely real and a big problem. therefore, UK government introduces measures Hopefully, we can curb or at least reduce that harm.
But why do people become addicted to gambling? And why is it often so difficult to treat compared to more “typical” substance-based addictions?
The “method” is relatively simple. The main attraction of gambling is essentially the ability to win large amounts of money with little effort.
When making decisions, humans brain You are constantly weighing effort against potential reward. When something leans heavily toward the latter (for example, paying a small amount of money and receiving a large amount in return), we tend to really approve of it.
Up to 4 percent of people in the United States may have a gambling problem – Photo credit: Getty
There's also the fact that the human brain is complex enough to recognize money as important in a biological sense, even though it's a technically abstract concept. Our brains also prioritize novelty and unpredictability.
All of this together means that gambling can and does affect the brain's reward system in the same way as certain drugs and substances. Addiction develops and all the subsequent effects are felt on the individual.
Of course, this does not happen to everyone who gambles. There are many people who don't gamble at all. Many people instinctively dislike risk and loss, but these are unavoidable aspects of gambling. However, some people are not as sensitive and are more willing to accept gambling as a form of entertainment.
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But while the similarities in the brain's responses to gambling and drugs may explain why gambling is often addictive, it is the combination of both that can make gambling addiction particularly difficult to treat. That's the difference.
Gambling addiction lacks a biological substance, making it easier to overlook and hide. As a result, some evidence suggests that 90% of gambling problems go unreported and untreated.
Also, the absence of specific substances that support gambling addiction means that there is nothing to “take away”, so to speak. Even in cases of long-term chronic drug addiction, there is an option to remove the drug (going “cold turkey”) and allow people's brains and bodies to adapt to the absence of the drug. Indeed, this is often a very unpleasant and even dangerous option. But it's still an option.
This is not the case with gambling. It is an action, not a substance. As long as someone has money and autonomy, it is very difficult to deny them access to gambling. Even if you could, it still might not make any difference because of your gambling experience.
The nature of gambling means that it is not experienced as a direct “stimulus = reward'' process of the kind that applies to drug taking and that underlies the basic learning processes of classical conditioning (which is why addiction is established in the first place). key aspects of the system). .
Such a relatively simple process is also easy to unlearn. When a stimulus stops producing a reward, the association “dies” in the brain. When you do this to the source of your addiction, the addiction loses its power over you. The human brain is so complex that this will be quite difficult to achieve, but at least we can try.
According to the Journal of Gambling Studies, men are twice as likely to be frequent gamblers than women – Photo courtesy of Getty
However, think about this. If an alcoholic found out that only one random drink out of 20 had alcohol in it and the others made him feel nauseous, it would probably be much easier to kick the habit. Dew. But that doesn't work with gambling. Because that's how you experience gambling.
Gambling rewards occur through a variable schedule of reinforcement. You never know when you will win, and losing is inevitable. But as long as you win often enough, keep doing it. And then an addiction to that behavior develops.
Knowing the negative consequences of gambling is already part of the process. It's like trying to treat an alcoholic by making him pay for his own drinks. They always already are.
These are just some of the reasons why gambling addiction is a difficult problem to address medically. This means it is essential to work towards reducing exposure to gambling and the development of addiction in the first place. We have to even the odds somehow.
It’s been said that in times of intense stress or sudden anger, a primitive part of our brain takes control. This irrational aspect of ourselves doesn’t stem from our highly evolved human faculties, but rather from the remnants of our reptilian ancestors that have persisted in our brains despite the process of evolution. Some call it the “lizard brain.”
The lizard brain theory was formulated by neuroscientists in the 1960s, particularly by Paul McLean. As he studied the brains of humans and other animals to explore the origins of negative emotions, he found common behaviors between reptiles and mammals related to survival instincts like establishing routines and defending territory, as well as unique mammalian behaviors.
Through his research and advancements in neuroscience allowing for the comparison of brain structures, MacLean proposed that the human brain evolved from a reptilian brain with ancient lizard characteristics still preserved. He identified three distinct brains within the human brain, which he called the “brain trinity”: the oldest reptilian brain, the paleomammal complex or limbic system, and the new structures that emerged with higher primate evolution.
Paul MacLean's 'Trinity Brain' model now widely discredited by scientists – Photo credit: Getty
Despite the popularity of the triune brain theory, recent studies have challenged the notion of the lizard brain. Neuroanatomists have pointed out that the brain is not structured like an onion with successive layers resembling different species’ brains, as the Trinity theory suggests.
For instance, while the amygdala within the limbic system is more developed in primates than in rats, indicating a more complex evolutionary trajectory, the concept of progress in evolution suggests that older animals are more primitive and newer ones more sophisticated. Evolution is not just about adding new features while leaving the old ones unchanged.
Explore our fascinatingcollection of fun factsand delve into more intriguing scientific topics.
Good neighborhoods are defined by the people who reside there. The presence of a helpful individual can enhance the community, while a negative neighbor can detract from its overall quality. The same concept applies to the brain, as revealed in a recent study indicating that brain cells behave like communities. Some cells contribute to a nurturing environment, promoting health and resilience in adjacent cells, while others spread stress and damage like bad neighbors.
Throughout one’s life, the composition of this brain community influences the aging process. Negative relationships can accelerate aging and lead to issues such as memory loss, while a healthy brain community can work collectively to combat aging. Researchers at Stanford University believe that these findings could potentially inform the development of treatments to slow or reverse aging.
Published in the journal Nature, the study identified 17 cells that influence aging positively or negatively. Notably, T cells and neurons were highlighted for their significant impact as bad and good neighbors, respectively. T cells, typically involved in fighting infections, can contribute to inflammation in the brain and hasten aging, while neural stem cells play a vital role in rejuvenation and maintaining a youthful brain.
The researchers conducted gene activity mapping across 2.3 million cells in the mouse brain, constructing a “spatial aging clock” to predict the biological age of individual cells. This innovative approach could lead to new biological discoveries and interventions, such as inhibiting pro-aging factors released by T cells or enhancing the efficacy of neural stem cells.
These findings have implications for understanding diseases like Alzheimer’s and potential strategies to strengthen the brain’s natural repair mechanisms and prevent cognitive decline. The research offers hope for uncovering ways to support brain health and combat aging-related challenges.
Researchers trained artificial intelligence model to measure people's age from brain scans
Laboratory/Alamy
The abundance of 13 types of proteins in the blood appears to be a strong indicator of how quickly the brain is aging. This suggests that blood tests could one day help people track and even improve their brain health.
Most previous studies have looked at protein markers of brain aging in the blood. Less than 1000 peoplesay nicolas seyfried from Emory University in Atlanta, Georgia, was not involved in the new study.
To get a broader idea of the effects of these proteins, Liu Weishi Researchers from Fudan University in China analyzed MRI brain scan data from around 11,000 adults (approximately 50 to 80 years old at the time of the images) who took part in the UK Biobank project.
Liu's team trained an artificial intelligence model using data from 70% of the participants to determine features of brain images, such as the size of different brain regions and how different parts are connected to each other. The age of the participants was predicted based on When the model was applied to the remaining 30% of participants, its predictions were accurate to within 2.7 years of their actual age.
The researchers then used the model to predict the age of another group of about 4,700 people, with an average age of 63, who also underwent brain imaging for UK Biobank. The researchers calculated the difference between these participants' actual ages and their AI-predicted ages, called the brain age gap. “The higher the age predicted by the AI compared to the actual age, the faster the brain ages,” Liu says.
The group also provided blood samples around the same time as the brain imaging. From this, the research team identified eight proteins that appear to increase in abundance as brain age increases, and five proteins that appear to decrease in abundance.
In an analysis of data from previous studies, researchers confirmed that these proteins are produced by brain cells and that their levels can influence the risk of dementia and stroke.
This suggests that blood tests for these proteins may reveal how quickly the brain ages. “These markers may be canaries in the coal mine that say, 'Hey, look, let's start doing interventions that slow brain aging while there's still plenty of time,'” Seyfried said.
But for this to be helpful, we need to know that these proteins can change with lifestyle changes. “If I run this much, I'll lose this much weight, if I change my diet, [then] We can correct these levels and bring them back into normal range,” Seyfried says.
Because the study was conducted primarily among wealthy white people, Seyfried said more research is needed to see if the results hold true for other populations with more diverse ethnicities and income levels.
The research team now hopes to conduct studies in animals to determine exactly how the 13 proteins affect the brain. For example, researchers might test whether disrupting levels of these proteins affects cognition or even the development of neurodegenerative conditions, Liu says. “In the coming decades, this could open up ways to target proteins to slow aging and disease.”
Tattoos printed on a person’s scalp can detect electrical activity in the brain and transmit the signals to a recording device.
Lu Nanshu
Printing temporary tattoos on people’s heads could make it easier to analyze their brain waves.
Electroencephalography (EEG) is a method of measuring electrical activity in the brain through electrodes placed on the scalp. It can be used to test patients for neurological conditions such as epilepsy, tumors, and damage from stroke or head trauma.
Because human skulls vary in size and shape, technicians must spend considerable time measuring and marking the scalp to obtain accurate values. The gel helps the electrodes detect brain signals, but when it dries it stops working. The cables that connect to the electrodes can also cause discomfort and interfere with delicate electrical signals.
Lu Nanshu A team of researchers at the University of Texas at Austin hopes to get around this problem by printing temporary tattoos on test subjects’ scalps. Tattoo ink is made of two polymers called poly(3,4-ethylenedioxythiophene) (PEDOT) and polystyrene sulfonic acid (PSS). It has excellent conductivity and durability, and does not irritate the skin.
A computer program creates a personalized tattoo design based on a 3D scan of your scalp, and a printer controlled by a robotic arm applies ink directly to your scalp. The ink comes in two different formulations, one for the electrodes that receive brain signals and one for the connection that goes to the back of the neck. From there, physical wires transmit the signal to small devices that record the data.
“Our technology embodies the first hair-compatible temporary electronic tattoo that enables high-quality brain monitoring,” says Lu.
This tattoo has been found to work well on bald heads and people with buzz-cut hairstyles. “This method has not yet been extensively tested on long, thick, curly hair, but it could be possible in the future by changing the nozzle design or incorporating robotic fingers into the hair parting. “It could be possible,” she says. The researchers say it is also possible to make the process completely wireless by embedding a data transmitter into the tattoo.
A recent study conducted by researchers at the University of Reading and the University of Durham has revealed that the increase in relative brain size, known as encephalization, during the seven million years of human evolution was a result of incremental changes within individual species.
Modern humans, Neanderthals, and other recent relatives on the human family tree evolved large brains much more rapidly than earlier species. Image credit: SINC / Jose Antonio Peñas.
“One of the most striking evolutionary changes in human evolution, closely linked to the unique cognitive and behavioral characteristics of humans, is the increase in brain size,” explained lead author Thomas Puschel and his colleagues.
“The question of encephalization in human evolution has been a topic of debate, with various studies comparing the brain capacities of different hominin species and exploring adaptive mechanisms that might have influenced differences in brain size among hominins. Our research proposes
“Some argue for a gradual growth pattern over time, while others suggest a pattern of rapid increases followed by periods of stagnation.”
“Certain studies support a combination of both models, while others claim that they are indistinguishable.”
In their recent study, the authors compiled the largest dataset of ancient human fossils spanning seven million years and utilized advanced computational and statistical methods to identify gaps in the fossil record.
These innovative approaches have provided the most comprehensive understanding to date of the evolution of brain size over time.
“This study has completely altered our perception of how the human brain evolved,” noted study co-author Professor Chris Venditti.
“Previously, it was believed that brain size varied significantly between species, like upgrading to newer computer models.”
“However, our study reveals a pattern of steady, incremental ‘software updates’ occurring within each species over millions of years.”
This study challenges the traditional notion that certain species, such as Neanderthals, remained unchanged and were unable to adapt, suggesting instead that the increase in brain size was a gradual and continuous driving force in evolution. It underscores the significance of changes.
“Major evolutionary shifts do not always require dramatic events,” Pushel stated.
“They can result from making small incremental improvements over time, akin to the learning and adaptation processes observed today.”
The researchers also identified a notable pattern: larger-bodied species tend to have larger brains, but the variation observed within individual species does not consistently correlate with body size.
Hence, the evolution of brain size over long evolutionary timescales spanning millions of years has been influenced by factors distinct from those observed within individual species, underscoring the complexities of evolutionary pressures on brain size. It’s remarkable.
“The reasons behind the evolution of large brains in humans are a key aspect of human evolution,” added study co-author Dr. Joanna Baker.
“Through analyzing the brain and body sizes of various species over millions of years, we have demonstrated that the characteristic large brains of humans primarily emerged through gradual changes within individual species. This became evident.”of study On November 26, 2024, Proceedings of the National Academy of Sciences.
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Thomas A. Puschel others. 2024. The increase in human brain size was revealed by intraspecific encephalization. PNAS 121 (49): e2409542121;doi: 10.1073/pnas.2409542121
We are able to enjoy music because of our ability to recognize musical boundaries.
NDAB Creativity/Shutterstock
We may finally understand how the brain processes beat drops: People use two distinct brain networks to predict and identify the transitions between musical segments.
Musical boundaries – the moments when one part of a composition ends and another begins – are important to enjoying music, especially in the Western musical tradition. Without them, he says, your favorite hits can sound like a monotonous, random stream of notes, “like reading a text without punctuation.” Ibarra Burnat Perez At the University of Jyväskylä, Finland.
To understand how the brain processes musical boundaries, she and her colleagues analyzed brain activity while listening to 36 adults listen to instrumental pieces from three different genres: Adios Nonino Astor Piazzolla, an American progressive metal band Stream of consciousness Dream Theater and Russian Ballet Classics ofSpring Festival Works by Igor Stravinsky. All of the listeners had attended school in Finland, and half of them considered themselves semi-professional or professional musicians.
The researchers found that just before musical boundaries, a brain network they call the early auditory network activates in anticipation of the end of a musical phrase. This network primarily involves auditory regions located in the posterior, or back, outer region of the brain called the cortex.
Another network becomes active during and after musical transitions. This network, called the border-transition network, is characterized by increased activity in auditory areas toward the middle and anterior, or front, parts of the cortex. Perez says that this change in brain activity between the two regions is similar to how the brain understands the difference between sentences in a language.
During and after the musical boundary, several brain regions, including the right ventrolateral prefrontal cortex, which is involved in complex cognitive tasks and decision-making, deactivate, suggesting that the brain redirects attention and resources to integrating new musical information as a new segment begins, Perez says.
Musicians and non-musicians also used these two brain networks differently. For example, musicians relied on brain regions important for higher-order auditory processing and integration, which may reflect a more specialized approach to understanding musical boundaries, Perez says. Non-musicians, on the other hand, showed greater connectivity across broader brain regions, indicating a more general approach.
In addition to shedding light on how the brain processes music, Perez says, these findings could also help develop music therapy for people who have difficulty comprehending language. For example, incorporating elements of musical boundaries into speech transitions (such as matching syllables to a melody) might make sentences easier to understand, she says.
Fragments of mitochondrial DNA can be added to the cell's main genome
wir0man/Getty Images
Mutations in which DNA from energy-producing mitochondria is mistakenly added to a cell's main genome were thought to be extremely rare. Now, studies of brain tissue show that such mutations occur in all of us, and their numbers may be a factor in ageing.
“Not only are they present, but they are abundant in the dorsolateral prefrontal cortex, an area of the brain associated with cognitive abilities.” Ryan Mills At the University of Michigan.
In human cells, almost all of the DNA (about 6 billion letters) resides in the nucleus, but the energy-producing organelles called mitochondria have their own tiny genome of about 16,600 letters.
That's because mitochondria were once free-living bacteria with their own large genome. In the roughly 2 billion years since those bacteria formed a symbiotic relationship with our distant ancestors, most of the original bacterial genome has been lost or transferred to the main genome in the nucleus.
This evidence of transfer has led biologists to know for a long time that fragments of mitochondrial DNA could somehow find their way into the nucleus and then be added to the main genome. But this kind of mutation was thought to be very rare, Mills says. Over the past few years, work by his team and others has shown that this isn't as uncommon as we thought. At least in cancer cells.
Mills and his colleagues showed that these types of mutations also occur in non-cancerous cells by sequencing the DNA of brain tissue samples taken from 1,200 people during post-mortem examinations.
Although another team took the samples and sequenced them, Mills and his colleagues looked for mutations that add mitochondrial DNA to the nuclear genome. “We were just curious,” Mills says.
Not only did they find such mutations, but they also found that they were more prevalent in people who, on average, died younger.
It's not clear whether these mutations are just a symptom of aging or a cause of it, Mills says. “The jury is still out,” he says. “But if you take the entire mitochondrial sequence and put it somewhere in the genome, it's hard for me to believe that it wouldn't have an effect.”
ohRan Knowles, a British teenager with a severe form of epilepsy called Lennox-Gastaut syndrome, became the first person to try the new brain implant last October, with astonishing results: his daytime seizures reduced by 80 percent.
“The device has had a huge impact on my son's life as he no longer falls and injures himself like he used to,” said his mother, a consultant paediatric neurosurgeon at Great Ormond Street Hospital in London (Gosh), who implanted the device. She added that there has been a huge improvement in her son's quality of life as well as his cognitive abilities. He is more alert and outgoing.”
Oran's neurostimulator is implanted under the skull and sends constant electrical signals deep into the brain with the aim of blocking the abnormal impulses that cause seizures.The implant, called Picostim, is about the size of a cell phone battery, is charged through headphones and works differently during the day and at night.
“The device has the ability to record from the brain, to measure brain activity, and we can use that information to think about how to improve the effectiveness of the stimulation that children are receiving,” says Tisdall. “What we'd really like to do is to make this treatment available on the NHS.”
As part of the trial, three children with Lennox-Gastaut syndrome will be fitted with the implant in the coming weeks, with a full trial planned for 22 children early next year. If the trial is successful, academic sponsors Ghosh and University College London plan to apply for regulatory approval.
Tim Denison, a professor of engineering science at the University of Oxford and co-founder and chief engineer at Amber Therapeutics, a London-based company that developed the implant in collaboration with the university, hopes that the device will be available on the NHS and around the world within the next four to five years.
The technology is one of a number of neural implants being developed to treat a range of conditions, including brain tumors, chronic pain, rheumatoid arthritis, Parkinson's disease, incontinence and tinnitus. These devices are more sophisticated than traditional implants in that they not only decode the brain's electrical activity but also control it, and this is where Europe is racing against the US to develop life-changing technology.
The latest generation of brain implants can not only detect brain activity but also control it. Photo: UCL
Amber isn't the only company working on brain implants to treat epilepsy. California-based Neuropace has developed a device that responds to abnormal brain activity and has been cleared by US regulators for use by people aged 18 and over. But the battery is not rechargeable and must be surgically replaced after a few years. Other devices are implanted in the chest with wires running to the brain that must be reinserted as the child grows.
When most people think of brain chips, they think of Neuralink, another California-based startup from Elon Musk that just implanted a brain chip in a second patient with a spinal cord injury. The device uses tiny wires thinner than a human hair to capture signals from the brain and translate them into actions.
The first recipient, Noland Arbaugh, was in January and is paralyzed from the neck down. Some of the wires had shifted and the implant needed to be adjusted. The implant allows Arbaugh to control a mouse cursor on a computer screen with his mind, as if he were watching a movie. Star Wars A Jedi who “uses the Force.”
Other US companies, such as Syncron, backed by Bill Gates and Jeff Bezos, have also recently implanted brain-computer interfaces (BCIs) in people who cannot move or speak.
But scientists say these implants simply decode electrical signals. In contrast, a number of companies in the U.S., Britain and Europe, like Amber, are working on so-called “BCI therapy,” or modulating signals in deep brain stimulation to treat disease. Amber's implants are also being used in academic trials for Parkinson's disease, chronic pain and multiple system atrophy, a condition that gradually damages nerve cells in the brain. The company is also sponsoring an early trial in Belgium to treat incontinence, with promising results.
Professor Martin Tisdall led the team that gave Oran Noorsson, who suffers from severe epilepsy, the implant last October. Photo: UCL
A different kind of technology will be tested in humans in clinical trials starting in a few weeks, using the first brain implant made from graphene, a “miracle material” discovered 20 years ago at the University of Manchester.
Medical teams at Salford Royal Infirmary will implant a device with 64 graphene electrodes into the brains of patients with glioblastoma, a fast-growing form of brain cancer. The device will stimulate and read neural activity with high precision, to spare other parts of the brain while removing the cancer. The implant will be removed after surgery.
“We use this interface to map out where the glioblastoma is and then remove it. [cut it out] “Without affecting areas of function such as language or cognition,” says Carolina Aguilar, co-founder and CEO of InBrain Neuroelectronics, the Barcelona-based company that developed the implant in collaboration with the Catalan Institute of Nanoscience and Nanotechnology and the University of Manchester.
Traditionally, platinum and iridium have been used in implants, but graphene, made from carbon, is ultra-thin, harmless to human tissue, and can be decoded and modulated very selectively.
InBrain plans to conduct clinical trials of similar artificial intelligence-powered implants in people with speech disorders caused by Parkinson's disease, epilepsy and stroke.
Professor Costas Kostarellos, head of nanomedicine at the University of Manchester, co-founder of InBrain and principal investigator on the glioblastoma trial, says the company's goal is to “develop more intelligent implantable systems”.
Equipped with AI, the device, with 1,024 electrical contacts, “will help provide optimal treatment for each patient without the neurologist having to program all those contacts individually, as they do today,” he says.
InBrain has partnered with German pharmaceutical company Merck to use its graphene device to stimulate the vagus nerve, which controls many bodily functions including digestion, heart rate and breathing, to treat severe chronic inflammatory, metabolic and endocrine diseases such as rheumatoid arthritis.
Galvani Bioelectronics, founded in 2016 by the UK's second-largest pharmaceutical company GSK and Alphabet's Verily Life Sciences, has a pioneering treatment that treats rheumatoid arthritis by stimulating the splenic nerve. Galvani has begun clinical trials with patients in the UK, US and the Netherlands, with first results expected within the next 6-12 months.
Bioelectronics, which combines biological sciences and electrical engineering, is a market worth $8.7 billion today and is predicted to reach more than $20 billion (£15 billion) by 2031. According to Verified Market Research:The field focuses on the peripheral nervous system, which transmits signals from the brain to organs and from organs to the brain. When brain-focused neuromodulation and BCIs are added, Aguilar believes the overall market could be worth more than $25 billion.
While U.S. neuromodulation companies are making waves with devices targeting chronic pain and sleep apnea, a growing number of European startups are also working on the technology. MintNeuro, a spinout from Imperial College London, Working on developing next-generation chips The company is developing an implant that can be combined into a smaller implant and has partnered with Amber. With the support of an Innovate UK grant, its first project will be to develop an implant to treat mixed urinary incontinence.
Geneva-based Neurosoft has developed a device that uses a thin metal film attached to stretchy silicon – soft enough to put less pressure on the brain and blood vessels – to target severe tinnitus, which affects 120 million people worldwide.
“Tinnitus begins with ear damage, typically caused by loud noise, but it can also cause changes in the wiring of the brain, making it effectively a neurological disorder,” said Nicholas Batsikouras, the company's chief executive officer.
Founded in 2009 by 13 neurosurgeons, neurologists, engineers and other scientists from the Policlinico Research Center and the University of Milan, Neuronica has developed a rechargeable deep brain neurostimulator that can be used to treat Parkinson's disease. The device provides closed-loop stimulation and adapts moment-to-moment to the patient's condition, and is currently being tested on patients.
“Europe and the UK can compete head-to-head with the US when it comes to getting treatments onto the NHS and distributing them around the world,” Denison said. “It's a fair competition and we're going to give it our all.”
The researchers studied mouse neurons in a part of the brain that is common to all mammals.
Klein & Hubert/naturepl.com
Scientists have identified neurons that become active when mouse pups interact with their mothers, seemingly reducing stress — and the same neurons may also be involved in the mother-child bond in humans.
The zona incerta, located in the center of the mammalian brain, is thought to be involved in integrating sensory information. As we develop, our roles change. In infants, neurons in the zona incerta send information to other brain regions, such as the cortex, promoting neural growth elsewhere.
Its role appears to be changing, Lee Yue Heon Researchers at the Yale School of Medicine and their colleagues suspected that this part of the brain may be involved in establishing a bond between mother and child.
To investigate, the researchers first assessed which neurons in the zona incerta become active when puppies, who are still dependent on milk, interact with their mothers. This involved surgically implanting fiber-optic probes in the brains of some of the puppies, allowing the researchers to detect light emitted when neurons became active.
The researchers found that activated neurons express a hormone called somatostatin, which regulates several bodily functions by inhibiting the release of other hormones, including the stress hormone corticosterone.
Free social interactions between mothers and infants activated these neurons, but contact with toys did not.
The researchers were also interested in how other social interactions might affect this brain region: They found that contact with lactating females who were not the pups' mothers, non-lactating females, siblings, or unrelated males also activated neurons, but not as much as contact with the pups' mothers.
“Our findings suggest that social interaction with the mother elicits the greatest response compared to other social stimuli, with a difference of about 1.5-fold in mean response levels,” the team said. Marcelo de Oliveira Dietrich, Even at Yale University.
In another part of the experiment, the team monitored the infants' brain activity while they were socially isolated: during these periods, which lasted between 10 minutes and 12 hours, no neurons were active, but this changed once the infants were reunited with their mothers.
Reunion also reduced the puppies' stress response, as measured by whether they made crying noises and released corticosterone.
Finally, the team wanted to see whether artificially activating neurons while the puppies were isolated could reduce stress in them: Activating the neurons using chemicals suppressed the puppies' crying and blunted their release of corticosterone.
The researchers believe that the zona incerta may be involved in early social relationships in mammals, as well as the development of other parts of the brain. “The distinct bond between infant and mother” is “a hallmark of mammals,” they write. The bond may be involved in the development of parts of the brain, with the zona incerta acting as “a nodal point that intertwines the elements that define mammalian biology.”
Robert Froemke A researcher from NYU Langone Health in New York says the study demonstrates that certain neurons “essentially serve to soothe infants,” but “it's still a bit unclear how infants sense their mothers — which aspects of smell, touch, or temperature are important,” he says.
“Another open question is how much contact is needed to send a safety signal, and how long that contact lasts? What promotes healthy development, as opposed to neglect?” In humans, “visual and auditory input — the sight and sound of the caregiver — is also likely to be important, or perhaps more important, than olfactory cues,” he says.
Activity within brain networks appears to differ between boys and girls
People Images/Getty Images
Artificial intelligence can now distinguish the brain patterns of 9- to 10-year-old boys and girls according to their sex and even gender, but not everyone is convinced of the accuracy of the results.
The prevalence of pain, headaches, heart disease, and other illnesses Varies by genderHowever, little is known about neurological variation in this regard or among sexes, particularly among children.
You can learn more and Elvisha Damara Researchers at the Feinstein Institute for Medical Research in New York analyzed thousands of sets of magnetic resonance imaging (MRI) data from more than 4,700 children, roughly equal in gender, all aged 9 to 10, who were participating in the Adolescent Brain and Cognitive Development Project.
Sex was defined based on “anatomical, physiological, genetic and hormonal structures at birth,” while gender was determined based on “an individual's attitudinal, emotional and behavioral characteristics.”
Parents weren't asked directly about their thoughts about their child's gender, but were assessed with a series of questions, such as how often their child imitates male or female characters on TV or in movies, whether they wanted to be a girl or a boy, whether they said they disliked their genitals, etc. All these questions were weighted equally and combined into a score.
A separate score was created from questions that asked the children themselves, such as whether they felt like a boy or a girl.
The researchers did not disclose the different genders the children identified as, or how many of the children had a gender that was different from their own gender. “We thought of gender as a continuum, not a binary,” Damala said. “We did not limit our analysis to gender categories, so we cannot comment on how many children had a gender that was different from their own gender.”
The researchers first looked at the relationship between brain networks and sex, and then looked at the relationship between these networks and sex for each assigned sex. They found that sex and gender differences were associated with distinct patterns of functional connectivity, a measure of communication between distant brain regions.
Gender was associated with connectivity between the visual cortex, which controls movement, and the limbic system, a group of deep brain structures involved in regulating emotion, behavior, motivation, and memory. These networks were “important in distinguishing participants based on their gender,” Damala said.
Gender-related networks were widespread throughout the cerebral cortex (the outer layer of the brain that is also associated with memory, movement, sensation and problem solving), both when using gender scores constructed from responses to parental questions and when using separate scores constructed by asking questions of the children themselves.
“In assigned females, sex mapped to networks involved in attention, emotion processing, motor control, and higher-order thinking,” Damala says. “In assigned males, the same relationships existed, but there were additional networks involved in higher-order thinking and visual processing. Although there was some overlap between sex- and gender-related brain networks, they were very distinct from each other.”
Once the researchers trained an AI model on some of the MRI data, it was able to identify a child's gender based on brain connectivity patterns in other datasets. It could also predict gender, but this was much less accurate and was based solely on the gender reported by parents, not the child themselves.
A better understanding of how brain activity patterns differ by sex could help scientists learn more about conditions that affect boys and girls at different rates, such as ADHD, Damala said.
The findings could also have implications for how human brain research is conducted, she says: “This shows that sex and gender need to be considered separately in biomedical research. This applies to how data is collected, how it is analyzed, and how results are interpreted and communicated,” Damala says.
but Ragini Verma The University of Pennsylvania researcher says the study tells us little about the neurological basis of gender. Because of the study's large sample size, the team was likely only able to find signals of different brain activity patterns between the sexes, but “any variability in gender predictions is based on low precision,” she says.
An astrophysicist and a surgeon walk into a bar. No, this is not the start of a bad joke. A few years ago, an astrophysicist Franco Vazza I met my childhood friend Alberto FerrettiAnd then he became a neurosurgeon. Vazza was modeling the structure of the universe, while Ferretti was delving into the brain. The two men reminisced and talked about their work. And then an idea occurred to them: What if they compared?
Vazza, based at the University of Bologna in Italy, has done just that. He used statistical techniques to compare neurons in a region of the brain called the cortex to the cosmic web, the pattern of matter distribution throughout the universe. Vazza looked at the number of nodes in each network and how densely connected each node is. The results surprised him.“It's a really interesting level of similarity,” he says. Ignoring the difference in the structures' sizes, which are about 27 orders of magnitude, “the two patterns kind of overlap,” Vazza says.
Some physicists cannot ignore this similarity, suggesting that the universe may “think” – that is, be conscious in some sense – an idea that has roots in the philosophy of panpsychism.
Traditionally, researchers have explained consciousness in one of two ways. Materialists argue that there is only matter, and consciousness somehow arises from that. Dualists argue that there are fundamentally two kinds of matter: matter and consciousness. There has been much discussion about the shortcomings of both views. For example, how can consciousness arise from pure matter?
Hydrogel-made brain sensor is small enough to be injected with a needle
Hanchuan Tang and Jianfeng Zang
Tiny sensors can be injected into the skull with a needle to monitor brain health until they dissolve within a few weeks. These sensors have been tested in animals, and in the future, they may enable minimally invasive, implantable sensors in the human body that can monitor traumatic brain injury and neurological disorders such as epilepsy.
“To my knowledge, this is the first wireless sensor that can monitor conditions inside the body without the need for surgery,” he said. Jules Magda The researcher is from the University of Utah, but was not involved in the study.
The sensor is a soft hydrogel cube about 2 millimeters wide, about the width of a grain of rice. Jiangfeng Zhan Professors from China’s Huazhong University of Science and Technology created structured “metagel” sensors by creating precisely spaced air columns throughout a hydrogel. When an external ultrasound source is aimed at the sensor, the channels guide the ultrasound waves. The shape of the sensor changes subtly in response to changing conditions in the brain, such as pressure or temperature, which can be seen in the reflected ultrasound.
“No wiring or electronics are required,” Zhang says. “It’s as if the metagel acts as a tiny acoustic mirror that changes its reflection depending on the environment.”
Zhang and his colleagues showed that when metagel sensors were injected into the brains of rats and pigs, they could measure pressure, temperature, pH levels, and flow rates in nearby blood vessels. They obtained results comparable to wired probes traditionally used to monitor brain health. Their experiments also found that metagel broke down into relatively harmless components, such as water and carbon dioxide, within four to five weeks.
Injecting the sensor into the brain requires a thick needle, which could still cause pain or discomfort, Magda said, and he noted that researchers also need to make sure the dissolved metagel is non-toxic.
Zhang says that the rats in the study showed little swelling in brain tissue or buildup of immune cells after the sensors were implanted and degraded, but he says that longer-term testing in larger animals is still needed to show that the metagel works reliably and safely before clinical trials in humans can begin.
Studies indicate that adolescents with internet addiction exhibit alterations in brain chemistry that can contribute to further addictive behaviors.
In a study published in PLOS Mental Health, researchers analyzed fMRI studies to explore how brain regions interact in individuals with internet addiction.
The findings revealed changes in neural network activity in the brains of young individuals, with increased activity during rest and reduced connectivity in areas involved in cognitive functions like memory and decision-making.
These alterations were linked to addictive behaviors, mental health issues, cognitive abilities, and physical coordination in adolescents.
The study reviewed 12 prior studies involving 237 young individuals diagnosed with internet addiction from 2013 to 2023.
Recent surveys show that nearly half of British teens feel addicted to social media platforms.
Lead researcher Max Zhang from the University of London emphasized the vulnerability of adolescents to internet addiction due to developmental changes during this crucial stage.
The study suggests that early intervention for internet addiction is essential to mitigate negative impacts on adolescent behavior and development.
Experts recommend targeted treatments focused on specific brain regions or therapies to combat internet addiction symptoms.
Parental education plays a crucial role in preventing internet addiction, enabling better management of screen time and impulsive online behaviors.
Lead author Eileen Li from GOS ICH emphasizes the importance of setting boundaries on internet usage and being mindful of its effects on mental and social well-being.
The COVID-19 pandemic has had long-lasting impacts on society and the health of millions of Americans who are still experiencing symptoms. Long-haul COVID-19 can result in chronic symptoms lasting for months, including weakness, palpitations, fatigue, headaches, and cognitive impairment. Scientists are still uncertain about the extent to which COVID affects brain function, leading to what is colloquially known as “brain fog.” Forgetfulness.
So, what causes brain fog in long COVID-19 patients? Researchers propose that the dysfunction of specialized cells lining the brain’s blood vessels plays a crucial role. Known as the Blood-Brain Barrier (BBB), this filter prevents toxins, pathogens, and large molecules from entering the brain. It is theorized that a leaky BBB could allow harmful substances to enter, disrupting normal processes and causing brain fog.
To investigate the link between a leaky BBB and COVID-related brain fog, researchers led by Matthew Campbell, PhD, and Colin P. Dougherty, PhD, examined the brains of patients previously infected with COVID. They studied a group of men and women over 18 years old, including 10 COVID survivors and 22 long-haul COVID patients (symptoms lasting more than 12 weeks), with 11 experiencing brain fog and 11 without it.
Using high-resolution MRI, the team measured BBB permeability by injecting a contrast agent into the patients’ blood to track blood flow through the BBB and into the brain. Patients with brain fog showed higher leakage rates compared to those without brain fog, suggesting a link between BBB dysfunction and persistent brain fog.
Further analysis revealed that patients with long COVID and brain fog had elevated levels of inflammatory markers in their blood, indicating brain inflammation potentially caused by a leaky BBB. The team also observed higher levels of a cell-signaling protein associated with chronic fatigue syndrome in patients with brain fog.
Investigating the immune system’s role in brain inflammation during long COVID, researchers examined gene activity in white blood cells. White blood cells from long COVID patients with brain fog showed significantly more active genes related to sustaining the immune response, suggesting ongoing inflammation causing BBB dysfunction and brain fog.
Lab experiments with brain cells exposed to patient blood samples further supported the link between inflammation, BBB dysfunction, and brain fog. Additionally, direct exposure of brain cells to COVID virus proteins resulted in increased inflammatory gene activity.
In conclusion, researchers found that BBB dysfunction during long COVID leads to chronic inflammation, contributing to brain fog. This insight may aid in understanding other long-term COVID effects and could guide future research on restoring BBB function to treat long COVID patients.
Continued use of drugs such as cocaine and morphine is thought to affect the way the brain prioritizes the body’s basic needs, but we are only now understanding how this happens.
When people repeatedly misuse drugs, they can experience long-term behavioral changes, where they choose to take drugs instead of doing what they need to do, such as eating or drinking.
A brain pathway called the mesolimbic reward system is thought to be involved in this process, but few studies have directly compared the system’s response to drug intake and its response when its innate needs are not met.
now, bowen tan from Rockefeller University in New York and colleagues showed that the same neurons are activated in these two situations. They revealed this using sophisticated microscopy equipment that can track the activity of individual neurons in the brains of mice in a state of withdrawal after repeated exposure to these drugs.
“There has long been a debate in this field about whether there are specialized cell types that encode only drug value and specialized cell types that encode only natural reward value,” Tan said. To tell. “What we saw is that these drugs of abuse typically activate the same set of neurons as natural rewards.”
The researchers also observed that after giving mice cocaine or morphine, their food and water intake decreased, while the neural responses needed to satisfy basic needs were disrupted.
“What’s really remarkable about this finding is that the strong neural responses to food and water are almost replaced by responses to drugs,” he says. Jeremy Day At the University of Alabama at Birmingham. “[This suggests] Drug rewards can override the way the brain converts desire states into behaviors that satisfy those desires.”
Tan and his team also identified a gene called.Rev which appears to be necessary for the drug to have this effect. Rev Because it is part of a cell signaling pathway that is also found in humans, future research could explore how inhibiting this pathway could be used as a treatment for substance misuse, he said. To tell.
Hala Point neuromorphic computer is powered by Intel’s Loihi 2 chip
Intel Corporation
Intel has developed the world’s largest neuromorphic computer, a device that aims to mimic the behavior of the human brain. The company hopes to be able to run more advanced AI models than traditional computers can run, but experts say the device will not be able to compete with, let alone surpass, the cutting-edge. says there are engineering hurdles to overcome.
Expectations for neuromorphic computers are high because they are inherently different from traditional machines. While regular computers use a processor to perform operations and store data in separate memory, neuromorphic devices use artificial neurons for both storage and calculation, similar to our brains. To do. This eliminates the need to pass data between components, which can be a bottleneck in today’s computers.
This architecture has the potential to result in much greater energy efficiency, and Intel says its new Hala Point neuromorphic computer will solve an optimization problem that involves finding an optimal solution to a problem given certain constraints. It claims to use 100 times less energy than traditional machines when running. It also trains and runs AI models that use chains of neurons, similar to how a real brain processes information, rather than mechanically passing input through each layer of artificial neurons as in current models. New methods may also become possible.
Hala Point contains 1.15 billion artificial neurons across 1152 Loihi 2 chips, capable of 380 trillion synaptic operations per second. mike davis Despite this power, Intel says it takes up only six racks of space in a standard server case, which is about as much space as a microwave oven. Larger machines will also be possible, Davis said. “We built a system of this scale because, honestly, one billion neurons was a good number,” he says. “So there were no special technical engineering challenges that would cause us to stop at this level.”
No other existing machine can match Harapoint’s scale, but Deep South, a neuromorphic computer due for completion later this year, is said to be capable of 228 trillion synaptic operations per second.
The Loihi 2 chip is still a prototype that Intel has produced in small numbers, but Davis said the real bottleneck is the processing required to take a real-world problem, translate it into a format that can run on a neuromorphic computer, and run it. It is said to be in the software layer. process. This process, like neuromorphic computing in general, is still in its infancy. “Software is a big limiting factor,” he says. That means there’s still little point in building a large machine.
Intel has suggested that machines like Hala Point could create AI models that continuously learn, rather than having to be trained from scratch to learn new tasks like current models do. Masu.but james knight Researchers at the University of Sussex in the UK dismissed this as “hype”.
Knight points out that current models like ChatGPT are trained using graphics cards running in parallel, which means many chips can be used to train the same model. But since neuromorphic computers operate on a single input and cannot be trained in parallel, it could take decades to even initially train something like ChatGPT on such hardware. He says it’s expensive, let alone come up with a way to enable continuous learning once it’s up and running.
Although current neuromorphic hardware is not suitable for training large-scale AI models from scratch, Davis said that one day pre-trained models could be used to learn new tasks over time. He said he hopes it will be possible. “Although this method is still in the research phase, this is a kind of continuous learning problem that large-scale neuromorphic systems like Hala Point can solve in a very efficient way in the future. “It’s considered,” he says.
Knight said neuromorphic computers could solve many other computer science problems as the tools needed for developers to write software for these problems to run on their own hardware become more mature. We are optimistic that we can improve this and increase efficiency at the same time.
It may also offer a better path toward human-level intelligence, also known as artificial general intelligence (AGI), although many AI experts believe that large-scale language models that power things like ChatGPT I think it’s impossible. “I think it’s becoming less and less of a controversial opinion,” Knight says. “The dream is that one day neuromorphic computing will allow us to create brain-like models.”
A lawyer representing O.J. Simpson, who passed away from cancer at the age of 76 last week, announced on Sunday that Simpson’s body will be cremated in the coming days and there are no plans to donate his brain for research purposes, according to his attorney Malcolm LaVergne.
LaVergne mentioned that there had been inquiries about studying Simpson’s brain for chronic traumatic encephalopathy (CTE), a degenerative brain disease linked to repeated head trauma in football players, but stated firmly that the entire body, including the brain, will be cremated.
Further details about the cremation and decision regarding brain research were first reported in The New York Post.
As the executor of Simpson’s estate, LaVergne mentioned plans for a small “celebration of life” gathering restricted to close friends and family. Simpson had three children from his previous marriages and was famously acquitted in the murders of his ex-wife Nicole Brown Simpson and Ronald Goldman in 1995.
Regarding financial matters, LaVergne expressed that he does not want the Goldman family, victims’ relatives, to receive any funds from Simpson’s estate. He acknowledged the need to handle the situation calmly and impartially.
Mr. Simpson’s debts, including those to the IRS, will be addressed as his estate is evaluated, and assets are inventoried to settle claims. Creditors will be prioritized for payment, with the Goldman family amongst them.
Despite potential legal battles over financial assets, Cook emphasized that the main goal is post-acquittal justice and accountability for the deaths of Brown Simpson and Goldman.
Looking ahead, LaVergne seeks funding for a suitable memorial at Simpson’s burial site as specified in his will, emphasizing the importance of carrying out his wishes without contention.
If you’ve ever felt like your cognitive abilities are not as sharp as they used to be, you might be struggling to recall names of actors or politicians in the news, for example. Perhaps mental arithmetic is not as easy for you anymore. This reflection may lead you to ponder the state of your brain and whether it’s on a downward trajectory.
It’s important to consider these aspects early on because brain development typically peaks in your 20s, and then cognitive functions gradually decline with age. Additionally, there is a growing risk of dementia, particularly associated with diseases like Alzheimer’s, in aging populations. However, both cognitive decline and dementia risk can be influenced by what experts call “modifiable risk factors,” offering a beacon of hope that there are lifestyle changes you can make to maintain mental acuity and lower the risk of dementia.
Be mentally active and boost your cognitive reserve
Psychologists and gerontologists often talk about cognitive reserve, which refers to the brain’s ability to adapt to aging and disease challenges. People with high cognitive reserve can perform well on cognitive tests despite exhibiting biological markers of Alzheimer’s disease, like protein build-up that impairs brain function. Engaging in activities such as reading, learning a new language, solving puzzles, and playing musical instruments can help boost cognitive reserve and maintain mental agility.
Interact with others
While brain-training games may not have broad benefits beyond the specific tasks they target, socializing with peers has been found to be a potent brain-training activity. Social isolation is considered a major risk factor for dementia, emphasizing the importance of engaging in lively conversations, joining clubs, or volunteering to keep your brain active and healthy.
Stay physically active
Physical activity not only benefits cardiovascular health but also contributes to better brain function and reduced cognitive decline. Incorporating exercises like running, swimming, or even gardening into your routine can help maintain cognitive abilities and lower the risk of dementia.
Eat a healthy diet
Avoiding excessive saturated fats and consuming plenty of fruits and vegetables can support brain health by eliminating harmful byproducts and providing essential nutrients. The Mediterranean diet, rich in fruits, vegetables, legumes, nuts, and olive oil, has been recommended for its brain-protective properties.
Stay curious
Personality traits like openness to experience are linked to better brain health and lower dementia risk. Activities that spark curiosity and awe can enhance cognitive abilities and mental flexibility. Incorporating habits like exploring new environments, trying new experiences, and enjoying cultural activities can promote brain health.
Think positively
Your mindset about aging can significantly impact your brain health. Maintaining a positive outlook, along with engaging in mentally stimulating activities and healthy habits, can contribute to long-lasting mental sharpness. Seeking out positive role models and adopting a proactive approach to brain health can help unlock your brain’s full potential.
Memory is a mysterious phenomenon. Some life events remain sharp in our memories no matter how long ago they occurred, while details from the previous day can quickly fade away.
A recent study published in the journal Science has uncovered the mechanism behind this phenomenon. Researchers have identified a system in the brains of humans and other mammals that determines which experiences are significant enough to be stored in long-term memory and which are forgotten.
Experiments conducted on mice demonstrated that specific patterns of brain activity called “sharp ripples” in the hippocampus, the area responsible for memory formation, occur during wakefulness. These patterns act as tags for important experiences, which are then transferred to long-term memory during sleep.
Although the study was carried out on mice, the lead author, Dr. Johnson, believes that the findings are applicable to humans as well, given the similarities in certain brain processes across mammalian species.
György Buzaki, the Biggs Professor of Neuroscience at New York University Langone Health, emphasized the unconscious nature of this memory consolidation process.
In the study, mice were rewarded with a treat after successfully navigating a maze, while their brain activity was monitored using implanted electrodes. The researchers observed that specific brain activity patterns observed during wakefulness were replayed during sleep, facilitating the conversion of important experiences into long-term memories.
This process highlights the crucial role that sleep plays in memory formation, as experiences deemed important during waking hours are transformed into lasting memories during rest.
According to the researchers, experiences that do not trigger the formation of sharp ripples are less likely to be stored in long-term memory.
To enhance the likelihood of memory retention, Dr. Buzaki suggests taking breaks after significant experiences to allow for the consolidation of memories.
Long-term memory requires relaxation
Research indicates that intentional pauses after experiences can aid in the formation of long-term memories. Dr. Buzaki recommends engaging in relaxing activities post-experience to facilitate the creation of sharp ripples in the brain, a process crucial for memory storage.
For example, after watching a movie, going for a leisurely walk can enhance the chances of remembering the film, as it allows for the encoding of memories.
Dr. Daniela Schiller, a professor of neuroscience and psychiatry at Icahn School of Medicine, highlighted the study’s intriguing discovery regarding brain activity patterns during rest and their resemblance to real-life experiences.
Dr. Daphna Shohamy, director of the Zuckerman Institute at Columbia University, emphasized the importance of pauses and bursts of brain activity in memory formation, noting that these elements enhance the likelihood of experiences being stored in long-term memory.
In conclusion, the study provides valuable insights into the unconscious mechanisms behind memory formation and underscores the significance of rest and relaxation in preserving lasting memories.
Living a healthier life can be achieved in many ways. Simple activities like daily walks, healthy eating, and brain-boosting puzzles like Sudoku can keep your mind and body active. For a unique approach, consider trying neuromodulation, which involves sending electric shocks to the brain.
Neuromodulation is an innovative method that uses a stimulator placed on the head to deliver electrical shocks directly to the nervous system. This non-invasive technique offers numerous health benefits and has gained traction as a cutting-edge technology for enhancing well-being.
The concept of neuromodulation has been around for some time, but companies like Parasin and gamma core have reignited interest in recent years. These companies claim to improve mental performance and overall health with their devices that can be used conveniently at home.
Research from reputable institutions like UCL, Harvard University, and University College London supports the effectiveness of neuromodulation. Even tech entrepreneurs like Brian Johnson have shown interest in this technology.
What is neuromodulation and how does it work?
Neuromodulation is a technique that alters neural activity by delivering electrical signals to specific areas. Imagine it as a dimmer switch that can increase or decrease nerve or brain activity. This method can excite or inhibit nerves to alleviate pain and modify neural patterns associated with various conditions like epilepsy and Parkinson’s disease.
Companies like Parasym use “auricular vagal neuromodulation therapy” to deliver electrical signals through the ear to target the vagus nerve, which plays a crucial role in connecting the brain, heart, and digestive system.
How technology can slow aging
Neuromodulation can help slow down the aging process by combating chronic inflammation, enhancing cognitive function, and improving cardiovascular health. Research shows promising results in addressing age-related issues like Alzheimer’s disease and heart conditions.
While neuromodulation offers benefits like improved heart rate variability and reduced fatigue and depression, it remains in the early stages of development. Safety concerns and experimental results underscore the need for further research and validation.
Is neuromodulation safe?
Neuromodulation has evolved since its inception in the 1960s, with modern devices providing safer options for users. Implantable devices offer more effective treatment but come with higher risks, including infections and other complications.
Non-invasive wearable devices like those from Parasym are considered safer, with minor side effects like skin irritation being the main concern. These devices require consistent use to deliver optimal results, making them a more accessible but less durable alternative to implantable devices.
While neuromodulation technology shows promise in improving health and well-being, users should weigh the benefits against the costs and potential risks before investing in these innovative devices.
Cerebellum of a person suffering from kuru disease
Liberski PP (2013)
Genetic research in a very remote community in Papua New Guinea has revealed new insights into a brain disease that is spread when people eat dead relatives and has killed thousands of people over two decades.
Dotted with mountains, gorges, and fast-flowing rivers, Papua New Guinea’s Eastern Highlands province is extremely isolated from the rest of the world, and it wasn’t until the beginning of the 20th century that outsiders realized that about 1 million people lived there.
Some tribes known as the Fore practiced a form of cannibalism called “funeral feasts,” in which they consumed the bodies of their deceased relatives as part of their funeral rites. This could mean they ingested an abnormally folded protein called a prion, which can cause a fatal neurodegenerative condition called kuru associated with Creutzfeldt-Jakob disease (CJD). However, the local people believed that the Kuru phenomenon was caused by witchcraft. At least 2,700 Kuru deaths have been recorded in the eastern highlands.
Simon Mead Researchers at University College London examined the genomes of 943 people representing 68 villages and 21 language groups in the region. Although this region of Papua New Guinea covers just over 11,000 square kilometers, smaller than Jamaica, researchers say the different groups are as genetically different as the peoples of Finland and Spain, some 3,000 kilometers apart.
The study found that not everyone who attended the funeral died from the disease. Mead and his colleagues say it appears communities were beginning to develop a resistance to kuru, which led to tremors, loss of coordination, and, ultimately, death.
The study found that some of the elderly women who survived the feast had mutations in the gene encoding the prion protein, which likely conferred resistance to kuru disease.
By the 1950s, funeral feasts had become illegal, and the kuru epidemic began to subside, but visitors say that the number of women in some villages had dwindled because so many women had died from kuru. It pointed out. Mead said women and children are most susceptible to the disease, likely because they ate the brains of deceased relatives.
However, genetic evidence shows that despite fears of the disease, there was a large influx of women into Fora tribal areas, particularly in areas where the highest levels of kuru were present.
“We believe it is likely that the sexual prejudice caused by Kuru caused single men in Kuru-affected communities to look further afield for wives than usual because they were unable to find potential wives locally. “We will,” Meade said.
He said the team wants to understand what factors confer resistance to prion diseases such as CJD, which caused a severe epidemic in the UK in the 1990s.
“[Our work sets] “This is a site to detect genetic factors that may have helped the Fore people resist kuru,” Mead said. “Such resistance genes may suggest therapeutic targets.”
Ira Debson Researchers from the Garvan Institute of Medical Research in Sydney, Australia, say the study provides new insight into the “rich and unique cultural, linguistic and genomic diversity” of the Eastern Highlands region.
“This is a demonstration of how genomics can be used to look almost back in time, reading the genetic signature of past epidemics and understanding how they have shaped today’s populations. It helps.”
Noland Arbor can play chess using Neuralink implant
Neuralink
Neuralink, the brain-computer interface company founded by Elon Musk, has revealed the identity of its first patient who says its implant “changed his life.” But experts say it’s not yet clear whether Neuralink has done more than replicate existing research efforts.
Who was Neuralink’s first patient?
Musk announced in January that the first human patient had received a Neuralink implant, but few details were released at the time. We now know from something. Live stream video by company – Who is that person and how will the test be done?
Noland Arbaugh explains in the video that an accident eight years ago dislocated his fourth and fifth vertebrae, leaving him a quadriplegic. He previously controlled the computer with a mouth interface, and is shown moving the cursor with just his thoughts, apparently using a Neuralink implant.
“Once I started imagining the cursor moving, it became intuitive,” Arbaugh says in the video. “Basically, it was like using ‘force’ on the cursor, and I was able to move the cursor anywhere I wanted. I could just look anywhere on the screen and the cursor would move where I wanted it. It was a very wild experience.”
He uses the device for reading, language learning, and computer games such as chess, and claims he uses it for up to eight hours at a time, at which point he needs to charge the device. “It’s not perfect, I’ve run into some problems. But it’s already changed my life,” he says.
What does the implant contain?
Neuralink did not respond to requests for an interview, but its website says the current generation coin-sized implant, called N1, generates neural activity through 1,024 electrodes distributed across 64 threads that extend into the user’s brain. It is said that it records. These are so fine that they must be placed by a surgical robot.
In a livestream video, Arbaugh said he was discharged from the hospital the day after his implant surgery, and that from his perspective the surgery was a relatively simple process.
The implant uses a small battery that is charged through the skin by an inductance charger and communicates wirelessly with an app on your smartphone.
Does this mean the first human trials were successful?
Reinhold Scherrer Researchers at the University of Essex in the UK will decide whether Neuralink’s first human trial was a success because the company “has not released enough information to form an informed opinion” He said it was too early.
“While the video is impressive and there is no doubt that it took a lot of research and development work to get to this stage, it is unclear whether what is being shown is new or groundbreaking,” he said. Masu. “Although control appears to be stable, most of the studies and experiments presented so far are primarily replications of past studies. Replication is good, but major challenges still remain. ”
Who else is working on brain implants?
Neuralink isn’t the only group exploring this idea. A number of academic organizations and commercial startups have already conducted human experiments that have successfully interpreted brain signals and produced some sort of output.
A team at Stanford University in California placed two small sensors just below the surface of the brain of a man who was paralyzed from the neck down. Researchers may be able to interpret the brain signals when a man decides to put pen to paper and translate them into text that can be read on a computer.
When will Neuralink be available and how much will it cost?
It’s too early to tell, as this has a long way to go before it becomes a commercial product, with much testing and certification to come. But Musk has made it clear that he intends to commercialize the technology.of The first product planned was named Telepathy.allows users to take control of their mobile phones and computers.
A 1,000-year-old human brain unearthed from a churchyard in Ypres, Belgium.The tissue folds, which are still soft and wet, are stained orange with iron oxide.
Alexandra L. Morton Hayward
Studies of human brains that have been naturally preserved for hundreds or thousands of years have identified 1,300 cases in which the organ survived when all other soft tissue had decomposed. Some of these brains are over 12,000 years old.
“This type of brain is the only one with preserved soft tissue and has been found in sunken ships and flooded graves with only floating bones.” alexandra morton hayward at Oxford University. “It's really, really weird.”
“To be honest, we don't expect the brain to be preserved in any environment,” she says. “As an archaeologist, if you were to dig a grave and find a brain rattling inside a skull, you would be shocked. But you don't expect soft tissue to be preserved, especially in a waterlogged environment. yeah.”
Morton-Hayward first became interested in brain preservation while working as a mortician. “The brain is known to be one of the first organs to decompose after death. I saw it liquefy pretty quickly. But I also saw it preserved.” she says.
Many researchers point out that the human brain is preserved more often than expected and in surprising circumstances, says Morton-Hayward. Now, she and her colleagues are conducting the first-ever systematic study of this phenomenon. They compiled a database of more than 4,400 preserved human brains found around the world.
They also collected and studied many preserved brains themselves. “We actually put it in an MRI machine, and that was a terrible mistake. We didn't know how much iron was in there,” says Morton Hayward.
In most cases, brain preservation can be explained by known processes. For example, the brains of sacrificial Incas buried atop volcanoes in South America around 1450 AD were freeze-dried along with the bodies, Morton-Hayward said.
2,400 years ago, the bodies and brains of swamp people like Tollundman, who was hanged and dumped in a swamp in what is now Denmark, were preserved through a tanning process similar to that used for leather.
Saponification, in which fatty substances are turned into a soap form called grave wax, also preserved the brains of some people who were shot and buried in mass graves in 1936 during the Spanish Civil War.
However, the known process preserves all soft tissue, not just the brain. They do not account for the 1300 cases in which the brain is the only surviving soft tissue.
“This unknown mechanism is completely different,” says Morton-Hayward. “The key feature of this device is that only the brain and bones remain. There is no skin, no muscle, and no intestines.”
For example, St. Hedwig of Silesia was buried in Poland in 1243. When her body was exhumed in the 17th century, it was discovered that her brain was preserved, and at the time it was thought to be due to divine powers.
Alexandra Morton Hayward holds a preserved 1000-year-old brain
graham poulter
Morton-Hayward's working hypothesis is that under certain circumstances, substances such as iron can catalyze the formation of cross-links between proteins and lipids, forming more stable molecules that resist degradation. The nature or ratio of proteins and lipids in the brain may be key.
“The mechanisms are similar to those seen in neurodegenerative diseases such as dementia,” she says. “So if we can understand what happens to the brain after death, we may be able to understand what happens to the brain as it ages during life.”
“It's great news that the data is being made public,” he says. brittany moeller He is one of the researchers at James Cook University in Melbourne, Australia who discovered that: Brain preservation is more common than thought. “This may raise researchers' awareness of the possibility of preserving brain material,” she says.
This is important because preserved brains are often the same color as the surrounding soil. “Therefore, it is very likely that brain material is not recognized for what it is and is frequently discarded during archaeological excavations,” Moller says.
Although this study focused on the human brain, the findings should also apply to animals. Morton Hayward says there are at least 700 examples of animal brains preserved as fossils, the oldest of which he says is an arthropod from 500 million years ago.
Cerebellum of a person suffering from kuru disease
Liberski PP (2013)
Genetic research in a very remote community in Papua New Guinea has revealed new insights into a brain disease that is spread when people eat dead relatives and has killed thousands of people over two decades.
Dotted with mountains, gorges, and fast-flowing rivers, Papua New Guinea’s Eastern Highlands province is extremely isolated from the rest of the world, and it wasn’t until the beginning of the 20th century that outsiders realized that about 1 million people lived there.
Some tribes known as the Fore practiced a form of cannibalism called “funeral feasts,” in which they consumed the bodies of their deceased relatives as part of their funeral rites.
This could mean they ingested an abnormally folded protein called a prion, which can cause a fatal neurodegenerative condition called kuru associated with Creutzfeldt-Jakob disease (CJD). there was. However, local people believed that the Kuru phenomenon was caused by witchcraft. At least 2,700 Kuru deaths have been recorded in the eastern highlands.
simon mead Researchers at University College London examined the genomes of 943 people representing 68 villages and 21 language groups in the region. Although this region of Papua New Guinea covers just over 11,000 square kilometers, smaller than Jamaica, researchers say the different groups are as genetically different as the peoples of Finland and Spain, some 3,000 kilometers apart. ing.
The study found that not everyone who attended the funeral died from the disease. Meade and his colleagues say it appears that communities were beginning to develop a resistance to kuru, which led to tremors, loss of coordination and, ultimately, death.
The study found that some of the elderly women who survived the feast had mutations in the gene encoding the prion protein, which likely conferred resistance to kuru disease.
By the 1950s, funeral feasts had become illegal and the kuru epidemic began to subside, but visitors say that the number of women in some villages had dwindled because so many women died from kuru. It pointed out. Mead said women and children are most susceptible to the disease, likely because they ate the brains of deceased relatives.
However, genetic evidence shows that despite fears of the disease, there was a large influx of women into Fora tribal areas, particularly in areas where the highest levels of kuru were present.
“We believe it is likely that the sexual prejudice caused by Kuru caused single men in Kuru-affected communities to look further afield for wives than usual because they were unable to find potential wives locally. “We will,” Meade said.
He said the team wants to understand what factors confer resistance to prion diseases such as CJD, which caused a severe epidemic in the UK in the 1990s.
“[Our work sets] “This is a site to detect genetic factors that may have helped the Fore people resist kuru,” Mead said. “Such resistance genes may suggest therapeutic targets.”
Ira Debson Researchers from the Garvan Institute of Medical Research in Sydney, Australia, say the study provides new insight into the “rich and unique cultural, linguistic and genomic diversity” of the Eastern Highlands region.
“This is a demonstration of how genomics can be used to almost look back in time, reading the genetic signature of past epidemics and understanding how they have shaped today’s populations. It helps.”
BLaine computer interface technology is at the heart of movies like Ready Player One, The Matrix, and Avatar. But outside of the world of science fiction, BCIs are used on Earth to help paralyzed people communicate, to study dreams, and to control robots.
Billionaire entrepreneur Elon Musk announced in January that his neurotechnology company Neuralink had implanted the first computer chip in a human. In February, he announced that patients can now control a computer mouse with their thoughts.
Neuralink’s purpose is noble. It is about helping people who are unable to communicate or interact with their environment. But details are scant. The project quickly raised alarms about brain privacy, the risk of hacking, and other potential issues.
Dr Steve Kassem, senior research scientist at Neuroscience Research Australia, said the Neuralink news should be taken with a “large pinch of salt”. It’s not the first company to do neural implants, he says. In fact, Australia is a ‘hotspot’ for relevant neurological research.
Does the patient dream of electric sheep?
The University of Technology Sydney project, which has received millions of dollars in funding from the Department of Defense, is now in its third phase to demonstrate how soldiers can use brain signals to control robotic dogs.
“We succeeded [demonstrating] Handa can use his brain to issue commands that direct the dog to reach its destination completely hands-free…so the dog can use its hands for other purposes. ” he says.
Soldiers use assisted reality glasses with special graphene interfaces to issue brain signal commands to send the robot dog to different locations. Lin said he is working on making the technology multi-user, faster and able to control other vehicles such as drones.
Meanwhile, Sydney company Neurode has developed a headset to help people with ADHD by monitoring the brain and sending electronic pulses to help them cope with changes. Another his UTS team is working on it. dream machine, which aims to reconstruct dreams from brain signals. It uses artificial intelligence and brainwave data to generate images from your subconscious mind.
And then there are the implants.
good signal
Synchron started at the University of Melbourne and is now based in New York. it is, Mesh inserted into blood vessels in the brain This allows patients to use the Internet by transmitting signals that operate similar to Bluetooth. People can shop, send emails, and communicate online using technology that controls computers.
Synchron has implanted and monitored mesh in many patients, including one in Australia. Patient P4, who has motor neuron disease, had mesh implanted several years ago.
“I think he’s had over 200 sessions,” says Gil Lind, Sychron’s senior director of advanced technology. “He is still progressing well with his implant treatment and is working very closely with us.
“He was able to use the computer through the system…As the disease progressed, it became very difficult to use the physical buttons.
“This allows for online banking, communication with caregivers, [with] Someone I love. ”
Dr Christina Maher from the University of Sydney’s Brain and Mind Center said Synchron’s technology is “miles ahead” of Elon Musk’s, and is more sophisticated and safer as it does not require open brain surgery. Stated. The researchers have also published more than 25 papers, she said.
“As for Neuralink, we don’t know much about it.
“My understanding is that the top priority for them is to test the effectiveness and safety of surgical robots…so they are focusing more on the robotic side of things, and this is a commercial It makes sense from a perspective.”
Need for regulation
But amidst the hype and promise of neurotechnology, there are concerns about who will have access to the beneficial technologies and how they will be protected.
Maher says it’s important to balance the need for innovation with appropriate regulation while allowing access to those who really need it. She says the “gap between the haves and have-nots” is being discussed not just in Australia but around the world.
“As brain-computer interfaces become more common, people will be divided into those who can afford them and those who cannot,” she says.
Lind said Synchron is focused on those who have the most to gain, such as quadriplegic patients. “We want to expand it as much as possible. We hope to reach a bigger market and help more people in need,” he says.
A personal and pivotal moment for him, he says, was seeing the faces of the clinicians, team, and family of the first patient who received a successful implant.
At Neuralink, Kasem warns that there are always risks when technology is developed by a company that exists to make a profit. “A cell phone plan for the brain is not what we want,” he says.
“And what if this gets hacked? There’s always a risk when it’s not a closed system.”
But it’s more likely that Neuralink will use people’s data.
“Like every app on your phone or computer, Neuralink monitors everything it can. Everything it can,” Kasem says.
“It will be stored somewhere.”
Protect your brain data
Maher agrees that data is a big issue, saying the risk of hacking remains when devices are connected to the internet. She says much of the social media, biometrics, and other data is already out there, but her brain’s data is different.
“meanwhile [BCI companies] They are subject to the same data privacy laws…The difference in many people’s minds is that brain data is very private and it’s your personal thoughts.
“The big picture here is that once you start recording large amounts of brain data, there are absolutely megatons of data out there,” she says.
Despite privacy concerns, Kasem says interacting with the brain has exciting potential.
“We need to remember how powerful and important the brain is. All you are, all you have been, and all you will ever be is your brain and nothing else.” he says.
Quoting American physicist Emerson Pugh, he says the brain has trillions of neural connections that lead to “infinite opportunities.” hand. ”
During the activities, participants wore headsets that detected brain waves and filled out questionnaires detailing their emotional states afterward.
Researchers discovered that when playing with Aro using sound-producing toys or taking him for a walk along a park path, participants’ alpha brain waves, indicating stability and relaxation, were more pronounced. This suggests an increased sense of rest and relaxation.
Engaging with Alo, brushing, and giving gentle massages to the dog strengthened beta brain waves associated with attention and concentration. This indicates improved concentration without added stress.
After completing all eight activities, participants reported feeling less stressed, tired, and depressed.
Studies have shown that activities like massaging Aro, offering treats, and hugs can enhance people’s moods. Participants also felt more at ease and relaxed while walking and massaging the dog.
“This study illustrates that certain activities with dogs can boost relaxation, emotional stability, alertness, concentration, and creativity by stimulating increased brain activity,” said Yoo. “Interacting with dogs can reduce stress and evoke positive emotional responses.”
Past studies indicate that dogs may help alleviate symptoms of depression and post-traumatic stress disorder, although the efficacy of the intervention remains ambiguous.
A 2022 survey revealed that veterans and first responders with service dogs experienced fewer PTSD symptoms than those without. However, having a dog as a pet had a minimal impact.
A 2020 clinical trial indicated that service dogs were slightly more effective in improving PTSD symptoms in veterans compared to emotional support dogs. Regardless, both types of dogs demonstrated some improvement in PTSD symptoms.
Therapy dogs from an organization called UCLA People-Animal Connection shake hands. Provided by Jennifer Dobkin
Research also suggests that for “pet therapy” to be effective, individuals must have a liking for animals.
“I was actually traumatized by dogs when I was younger, so I never fully embraced them to know if I would feel the same level of comfort,” stated Kathryn Magruder, a professor of psychiatry at the university and author of the 2020 clinical trial.
Jennifer Dobkin manages an animal therapy program called UCLA People-Animal Connection for medical patients and staff and has witnessed firsthand how interactions with dogs can aid in focus and relaxation.
“Staff members who are stressed and having a rough day visibly relax their posture. They smile. They tell us things like ‘You have no idea how much I needed this,'” she remarked.
Dobkin recounted a situation where her terrier mix dog, Toto, helped a grieving family find solace amid the sorrow and stress of losing a loved one.
Children at Stuart House in Santa Monica, Calif., also engaged with therapy dogs like a golden retriever and Labrador named North, bringing comfort and support to those coping with traumatic experiences.
“Our dogs are present to help children navigate discussions about extraordinarily stressful events they have endured. I believe it aids in concentration and provides a sense of comfort,” Dobkin concluded.
Neuroscientists at the University of Michigan have identified thermoreceptors that mediate the sensation of cold in somatosensory neurons.
GluK2 KO mice have a defect in cold sensing.Image credit: Kai other10.1038/s41593-024-01585-8.
“The field began elucidating such temperature sensors more than 20 years ago with the discovery of a heat-sensing protein called TRPV1,” said Professor Sean Hsu of the University of Michigan.
“While various studies have discovered proteins that sense hot, warm, and even cold temperatures, we have not identified any proteins that sense temperatures below about 15 degrees Celsius (60 degrees Fahrenheit).”
In 2019, scientists discovered The world's first cold receptor protein Caenorhabditis elegans a millimeter-long nematode species that the lab is studying as a model system for understanding sensory responses.
Because the gene that codes for it is Caenorhabditis elegans This protein is evolutionarily conserved across many species, including mice and humans, and this discovery was a starting point for testing cold sensors in mammals. Glutamate ion channel receptor kainate type subunit 2 (GluK2).
In a new study, Professor Xu and colleagues tested that hypothesis in mice with the deficiency. GluK2 Because of the gene, the GluK2 protein could not be produced.
Through a series of experiments testing animals' behavioral responses to temperature and other mechanical stimuli, they found that mice responded normally to hot, warm, and cold temperatures, but not to harmful cold.
GluK2 is primarily found in neurons in the brain, where it receives chemical signals and facilitates communication between neurons.
However, it is also expressed by sensory neurons in the peripheral nervous system (outside the brain and spinal cord).
“We found that this protein serves a completely different function in the peripheral nervous system, processing temperature cues instead of cold-sensing chemical signals,” said Dr. Bo Duan from the University of Michigan.
of GluK2 This gene has relatives across the evolutionary tree, going back to single-celled bacteria.
“Bacteria don't have brains, so why have they evolved a way to receive chemical signals from other neurons?” Professor Xu said.
“But the need to sense its environment, and perhaps both temperature and chemicals, will be very strong.”
“Thus, I suspect that temperature sensing is an ancient function, at least for some of these glutamate receptors, that was eventually adopted as organisms evolved more complex nervous systems. .”
of result appear in the diary natural neuroscience.
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W. Kai other. The kainate receptor GluK2 mediates cold sensing in mice. nut neurosi, published online on March 11, 2024. doi: 10.1038/s41593-024-01585-8
Alzheimer’s disease is a neurological disease that impairs brain functions such as memory and reasoning, and there is currently no known cure. People with this disease begin with basic forgetfulness, gradually lose control of their motor skills, and eventually become unable to complete normal daily activities.
Scientists have discovered that abnormal proteins that accumulate in and around brain cells are the main cause of Alzheimer’s disease. They also discovered that the disease depends on genetics, aging, and lifestyle choices such as being active and eating a healthy diet. However, it is not known how other disorders, such as sleep disorders, may exacerbate symptoms.
Scientists have hypothesized that brain activity during sleep may be related to Alzheimer’s disease because many important memory-related events occur during sleep. Scientists are therefore hoping to find out whether disruptions in brain function during sleep are related to the development of Alzheimer’s disease.
Researchers at Washington University in St. Louis recently tested whether Alzheimer’s disease is related to electrical activity that occurs in the brain during sleep. Most people experience changes in brain activity early in the night as the body relaxes and goes to sleep. Each of these changes sleep vibration event, lasts about 20-40 minutes. The researchers hypothesized that the interactions of brain circuits during sleep oscillations are different in patients with early Alzheimer’s disease and could be used for diagnostic purposes.
To test their hypothesis, the scientists used a machine that measures electrical activity in the brain. electroencephalograph, or brain waves.They chose 205 political partiesParticipants who have previously completed at least 3 nights of EEG measurements, 1 night of home sleep apnea testing, and clinical dementia testing.Based on dementia testing, most One participant had no cognitive impairment, some participants had very mild cognitive impairment, and one participant had mild cognitive impairment.
The researchers asked participants to wear the EEG as a headband while they slept, allowing them to measure brain waves during the sleep oscillation phenomenon. The three types of sleep oscillatory events they measured during the experiment were: theta burst, sleeping spindleand slow waves.
The researchers explained that theta bursts occur when humans are in light sleep and help process information and form memories. Sleep spindles occur during non-rapid eye movement sleep and are involved in memory consolidation. Slow waves occur during deep sleep, slowing heart and breathing rates, and also play a role in memory development.
The researchers categorized each patient’s individual slow-wave events by how often they coincided with sleep spindles and theta bursts. They classified sleep spindle and slow wave events that occur within 1.5 seconds of each other as coupled events. They also classified theta burst and slow wave events that occurred within 0.5 seconds of each other as coupled events.
The researchers found that people with cognitive impairment had weaker electrical activity during theta bursts and greater differences in brain electrical activity during theta bursts and slow waves. They also found that people with cognitive impairment and other biomarkers of Alzheimer’s disease had fewer slow waves with theta bursts and sleep spindles. The researchers interpreted their results to confirm that disruptions in brain circuits involved in memory function during sleep may be associated with Alzheimer’s disease.
The researchers concluded that the EEG pattern of sleep oscillatory events could be used as a biomarker for Alzheimer’s disease. Researchers suggested that early signs of the neurodegenerative process associated with Alzheimer’s disease could be detected in sleeping patients’ brain waves, even before they develop cognitive symptoms. They also believe that the results may provide an accessible and cost-effective tool for monitoring brain health and early Alzheimer’s disease, allowing for earlier responses and improved patient treatment. suggested something.
Some cancer treatments can cause so-called chemobrain, commonly defined as problems with memory and concentration.
One Bar/Alamy
An experimental treatment for Alzheimer’s disease that involves flickering lights and low-pitched sounds may also help prevent cognitive impairment after cancer treatment, also known as chemical brain, a study in mice suggests.
In the case of Alzheimer’s disease, light and sound stimulation has been shown in small human trials to reduce memory and concentration problems, but larger studies are still investigating it.
The light flashes 40 times per second, or 40 Hz, and the sound also has a frequency of 40 Hz. This frequency was originally chosen because the brainwave intensity of Alzheimer’s patients is lower than 40 Hz and is associated with memory processing. The idea was that this treatment would stimulate these brain waves.
Subsequent research has shown that such brain waves may have a wide range of benefits for the brain, including increased immune cell activity and, more recently, strengthened drainage systems that may help remove a toxic protein called beta-amyloid. It suggests that there is.
Cai Li Hui The Massachusetts Institute of Technology researchers who developed this approach thought it could help cancer patients who have memory and concentration problems after chemotherapy and other cancer treatments. It is thought that these may be caused by damage to brain cells, but the exact mechanism is unknown and there is no cure.
In the latest study, Professor Tsai’s team exposed cancer-free mice to light and sound for one hour a day while being given a common chemotherapy drug called cisplatin, compared to those who had just received chemotherapy. They found that they experienced less decline in mental acuity than mice.
Acuity was assessed by a memory test in which mice were exposed to either new or familiar objects, and the animals typically showed more interest in things they had never seen before. Chemotherapy reduced the mice’s ability to identify objects, but this was prevented by light and sound treatment.
The therapy had several effects, including reducing inflammation in the brain, reducing DNA damage, and reducing the loss of myelin, the insulation around nerve cell fibers.
nazanin derakshan Researchers at Britain’s University of Reading say the idea needs to be tested in people to see if it has any overall benefits. If this treatment is given at the same time as chemotherapy and reduces cell death in the brain, it may help cancer cells survive there, she says.
According to a new study from Washington University in St. Louis, individual neurons work together to generate rhythmic waves that propel fluid through dense brain tissue, cleaning it in the process.
Accumulation of metabolic waste products is a major cause of many neurological diseases, but there is still limited knowledge about how the brain performs self-cleaning.Jean Xie other. They demonstrate that neural networks synchronize individual action potentials to generate large-amplitude, rhythmic, self-perpetuating ion waves within the brain's interstitial fluid. Image credit: Jiang-Xie other., doi: 10.1038/s41586-024-07108-6.
“These neurons are miniature pumps,” said Dr. Li-Feng Jiang-Xie, lead author of the study.
“Synchronized neural activity facilitates fluid flow and removal of debris from the brain.”
“If we can develop this process, we could slow or prevent neurological diseases such as Alzheimer's disease and Parkinson's disease, where excess waste products such as metabolic waste and junk proteins accumulate in the brain and cause neurodegeneration. It may be possible.”
Brain cells form a dynamic network that coordinates thoughts, emotions, and body movements and is essential for memory formation and problem solving.
But to perform these energy-intensive tasks, your brain cells need fuel. When you take in nutrients from your diet, metabolic waste products are produced in the process.
“It is important that the brain processes metabolic waste products that can accumulate and contribute to neurodegenerative diseases,” said Professor Jonathan Kipnis, senior author of the study.
“We knew that sleep is a time when the brain begins a cleansing process to flush out waste and toxins that have accumulated during wakefulness. But how does that happen? I didn't understand.”
“These findings may point us to strategies and potential treatments to accelerate the removal of hazardous waste and remove it before it leads to dire consequences.”
However, cleaning the dense brain is not an easy task. The cerebrospinal fluid that surrounds the brain enters a complex network of cells, collecting toxic waste as it passes through it.
On leaving the brain, contaminated fluids must pass through a barrier in the dura mater (the outer layer of tissue that surrounds the brain under the skull) before flooding into the lymph vessels.
But what powers the flow of fluid into, into, and out of the brain?
“Researchers studied the brains of sleeping mice and discovered that neurons work together to fire electrical signals that generate rhythmic waves in the brain, prompting cleaning efforts,” says Jean. Dr. Shi said.
The study authors determined that such waves drive fluid movement.
They silenced certain brain areas so that neurons in those areas no longer produced rhythmic waves.
Without these waves, fresh cerebrospinal fluid cannot flow through the silenced brain areas and trapped waste products cannot exit the brain tissue.
“One of the reasons we sleep is to cleanse the brain,” Professor Kipnis says.
“And if we can enhance this cleansing process, perhaps we can sleep less and stay healthy.”
“Not everyone can benefit from eight hours of sleep each night, and lack of sleep can affect your health.”
“Other studies have shown that mice genetically short-sleeping have healthier brains.”
“Is it to remove waste products from the brain more efficiently?”
“Is it possible to strengthen the brain purification ability of people suffering from insomnia so that they can live with less sleep?”
of study Published in the Journal on February 28, 2024 Nature.
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LF.Jean Xie other. Neurodynamics directs cerebrospinal fluid perfusion and brain clearance. Nature, published online on February 28, 2024. doi: 10.1038/s41586-024-07108-6
Cross-section of a mouse brain highlighting neurons that appear to release molecules that increase toxin clearance
Tsai Laboratory/MIT Picower Laboratory
A new explanation has emerged for why an experimental treatment for Alzheimer’s disease that involves flickering sounds and lights may help slow cognitive decline. This frequency appears to strengthen the brain’s waste processing network, helping to remove beta-amyloid and other toxic proteins that contribute to memory and concentration issues.
“Once we understand the mechanism, we can probably understand how to further optimize this whole concept and improve its effectiveness,” he says. Cai Li Hui at Massachusetts Institute of Technology.
The treatment involves exposure to light that flashes at a frequency of 40 times per second, or 40 hertz, and to a bass sound, also at 40 hertz. Typically, stimulation is given for one hour per day.
The key to this new approach is that large networks of brain cells naturally fire in sync with each other at different frequencies, known as brain waves. Brain waves around 40 Hz are common when people are concentrating and forming or accessing memories.
In 2016, Tsai’s team wondered if 40Hz stimulation could enhance cognitive performance in Alzheimer’s patients, since visual or auditory stimulation at a certain frequency is known to enhance brain waves at that same frequency. I decided to investigate.
Their group and other researchers have shown that this reduces amyloid accumulation in mice with Alzheimer’s disease and has cognitive benefits. Small trial in people with this condition, an even larger trial is underway. However, it is unclear how this treatment works, and another idea is that it boosts the function of immune cells in the brain.
Well, the special light and sound appears to work by enhancing the function of the brain’s drainage system, also known as the glymphatic system.
In the latest study, Tsai’s team conducted a series of experiments to study the mechanism of treatment in mice that were genetically modified to have amyloid buildup that normally occurs with age and to have worse memory than typical mice. carried out.
As expected, when the animals were exposed to light and sound, the amount of amyloid decreased. The new findings were that during treatment, the amount of cerebrospinal fluid entering the brain increased, and the amount of waste fluid leaving the brain through the glymphatic vessels increased.
This appears to occur because nearby blood vessels pulsate more, which may help glymph fluid flow through the blood vessels, allowing more water to flow into the glymph system.
The research team also found that the activity of a particular type of brain cell known as an interneuron appears to cause an increase in glymph flow by releasing a molecule called vasoactive intestinal peptide. When the research team chemically blocked the production of this molecule, the treatment no longer accelerated amyloid clearance.
Miken Nedergaard A professor at the University of Rochester in New York who helped discover the glymphatic system says the discovery is consistent with what we already know about it. “The brain, blood, and cerebrospinal fluid are all contained within the skull. When the blood volume expands, the brain tissue cannot be compressed, so the cerebrospinal fluid volume must also move.”
In the accompanying article natural medicineDr. Nedergaard says that a better understanding of the mechanisms of toxin removal in the brain “could be the key to unlocking that.” [their] Treatment Possibilities.”
we heard it all. Men's brains are larger and have better spatial awareness. Women's brains are adapted for multitasking and emotional intelligence. Stereotypes about how sex influences behavior abound, and as increasingly sophisticated brain-scanning technology emerges, claims about such inconsistencies are becoming more apparent.
But as we discovered in our feature on the human brain (“Your Amazing Brain: 10 Challenging Questions That Uncover Amazing New Discoveries About the Human Brain”), men's and women's behaviors, interests, We are trying to identify the biological reasons for population differences in . The issue of occupation is a delicate debate that includes not only sex but also gender, and has never been resolved.
Still, we should keep trying. In particular, if there really are gender-related brain differences, this would have a major impact on our health. That's because many pathologies related to the brain and neural branches affect men and women at different rates and in different ways. For example, women have higher rates of depression, anxiety, and eating disorders. Men have higher rates of autism and attention deficit hyperactivity disorder.
There are many possible reasons for this imbalance in the gender ratio. For example, autism may be underdiagnosed among girls, or typical behaviors may manifest differently. Similarly, biological factors may make women more susceptible to depression because they tend to have lower incomes or because men are less likely to seek help for mental health problems. .
However, brain differences between the sexes may also exist. If so, the photo is not yet complete. These may not be due to direct genetic or sex hormonal effects, but may be due to the way society generally treats men and women differently throughout their lives.
Elucidating all of this could shed light on the mechanisms behind these symptoms and lead to better treatment strategies. After all, this is not a competition between male and female brains, but an initiative that has the potential to help everyone.
Micrograph of a cross-section of a mouse brain highlighting neural pathways (green)
Mark and Mary Stevens Neuroimaging and Informatics Institute/Scientific Photo Library
By analyzing a mouse’s brain activity, scientists can tell where the animal is and the exact direction the mouse is looking. With further research, the findings could one day help robots navigate autonomously.
The mammalian brain uses two main types of neurons for navigation. “Head direction cells” indicate where the animal is facing, and “grid cells” help provide her two-dimensional brain map of where the animal is located.
To learn more about the firing of these neurons, Vasilios Marlas and colleagues at the University of Tennessee, Knoxville, worked with the U.S. Army Research Laboratory to analyze data from previous studies.
In this experiment, probes were inserted into the brains of several mice. They then combined data about their neural firing patterns with video footage showing their position and head position as they moved around their open environment.
Because of this, Marlas and his colleagues developed an artificial intelligence algorithm that can figure out where the mouse is looking and where it is.
In practice, it’s similar to the drop pins and directional arrows on your smartphone’s map app, except instead of connecting to GPS satellites, scientists analyze the subjects’ brain activity.
“This method eliminates the reliance on updating GPS coordinates based on preloaded maps, satellite data, etc.,” Marulas says. “In a sense, the algorithm ‘thinks’ and perceives space in the same way as a mammalian brain.”
AI could eventually allow intelligent systems to move autonomously, he says. “In other words, we are taking advantage of the way the mammalian brain processes data and incorporating it into the architecture of our algorithms.”
Adam Hines Researchers from Australia’s Queensland University of Technology say the smartphone app analogy is helpful. “The location information (drop pin) and the direction (blue arrow) match, and during navigation, as he moves, the two pieces of information are constantly updated. Grid cells are like GPS, heading cells are It’s like a compass.”
The lamprey and human hindbrains are built using very similar molecular and genetic toolkits, according to a new study led by the Stowers Institute for Medical Research.
These images show an adult lamprey (top and left) and a developing lamprey embryo. Image credit: Stowers Medical Research Institute.
“Our research on the hindbrain (the part of the brain that controls important functions such as blood pressure and heart rate) is essentially a window into the distant past and can serve as a model for understanding the evolution of complexity. “, said Dr. Hugo Parker. Researcher at Stowers Medical Research Institute.
Like other vertebrates, sea lampreys have a backbone and skeleton, but they noticeably lack a jaw, a characteristic feature of the head.
Most vertebrates, including humans, have jaws, so this striking difference in sea lampreys makes it a valuable model for understanding the evolution of vertebrate traits.
“About 500 million years ago, at the origin of vertebrates, there was a split between jawless and jawed animals,” said Dr. Alice Bedois, also of the Stowers Institute for Medical Research.
“We wanted to know how vertebrate brains evolved and whether there is something unique to jawed vertebrates that jawless vertebrates don't.”
Previous research had identified genes that structure and subdivide the sea lamprey's hindbrain as identical to genes in jawed vertebrates, including humans.
However, these genes are part of an interconnected network or circuit that needs to be initiated and directed to properly build the hindbrain.
In a new study, the authors identify common molecular cues known to direct head-to-tail patterning in a variety of animals as part of a genetic circuit that guides hindbrain patterning in the lamprey. .
“We found that the same genes, as well as the same cues, are involved in hindbrain development in sea lampreys. This suggests that this process is ancestral to all vertebrates. ,” Dr. Bedwa said.
“This signal is called retinoic acid, commonly known as vitamin A.”
Researchers have known that retinoic acid signals the genetic circuits that build the hindbrains of complex species, but they believe it is involved in more primitive animals like sea lampreys. was not considered.
Surprisingly, they discovered that the lamprey's core hindbrain circuit is also initiated by retinoic acid, providing evidence that these sea monsters and humans are much more closely related than expected.
“People thought that because lampreys don't have jaws, their hindbrains don't form like other vertebrates,” says Dr. Rob Krumlauf, a researcher at the Stowers Institute for Medical Research.
“We showed that this fundamental part of the brain is built exactly the same way as in mice, and even in humans.”
Signaling molecules that signal cell fate during development are well known.
Now, researchers have discovered that retinoic acid plays another key role in signaling important steps in development, such as the formation of the brainstem.
Furthermore, if hindbrain formation is a conserved feature in all vertebrates, other mechanisms must be involved to explain its incredible diversity.
“We all come from a common ancestor,” Dr. Bedwa said.
“The lamprey provided further clues.”
“We now need to go further back in evolutionary time to discover when the genetic circuits controlling hindbrain formation first evolved.”
of study It was published in the magazine nature communications.
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AMH Bedwa other. 2024. Lamprey reveals the origins of retinoic acid signaling and its coupling to vertebrate hindbrain segments. Nat Commune 15, 1538. doi: 10.1038/s41467-024-45911-x
It's easy to name people who have evolved human thinking, from Jane Austen to Albert Einstein, Zaha Hadid to Ai Weiwei, but why are these people so much more creative than others? It's much more difficult to explain what kind of thinking you do. Are their brains just built that way, or can anyone learn it? The mystery of creativity has long puzzled scientists. Now, researchers are finally making some progress towards closing the curtain. Even better, their insights can help us all exercise a little more original thinking.
Some of them are exciting insights This stems from the “dual process theory” of creativity, which distinguishes between idea generation and idea evaluation. Idea generation involves digging deep into existing knowledge for seeds of inspiration. Perhaps it is done by drawing analogies from completely different areas. Free association is key at this stage, as one thought leads to another, more original insight. The second phase, idea evaluation, requires you to apply a more critical eye to select the ideas that best fit your goals. Novelists must decide whether strange, supernatural plot twists will excite readers or turn them off. Engineers must consider whether a fish-inspired airplane would be practical and efficient. Large projects require these two stages to be repeated many times during the long and winding journey from concept to completion.
Brain scans of people engaged in creative problem solving suggest that idea generation and evaluation relies on…
Crescent Nebula: More complex than the human brain?
Reinhold Wittich/Stocktrek Images/Alamy
Back in 2012, neuroscientist Christoph Koch wrote in his book: Consciousness: Confessions of a Romantic Reductionist The human brain is “the most complex object in the known universe.” This seems intuitive, given that the brain has approximately 86 billion neurons, which are connected in ways that are still beginning to be understood. But when I put it, David Wolpert At New Mexico's Santa Fe Institute, founded in the 1980s as a hub for the budding field of complexity science, he doesn't think so. “It's almost a travesty that we are the most complex system in the universe,” he says. “That question is actually misguided.”
Nevertheless, I persevere. Is there a common measure of complexity that can be applied to complex systems of all kinds? After all, if you squint, galaxy clusters and the filaments that connect them look like intertwined circuits of neurons. Masu. The human brain even has almost as many neurons as there are galaxies in the observable universe. This formal similarity may have something to do with the general laws by which complexity emerges, he says. Ricard Sole At Pompeu Fabra University in Barcelona, Spain. Or maybe not. “By chance, it might show up in both systems, but that doesn't mean anything,” he says.
Moreover, complexity is not defined by components and their interconnections. It's the idea that the whole is more than just something.
The human brain is likely the most advanced computer in the world. While it operates differently than a traditional computer and has a much softer structure, its computing power is unparalleled.
Neuromorphic computing, which models machines after the human brain and nervous system, has been a growing concept since the 1980s. Many attempts have been made to achieve this, with the DeepSouth project at the International Center for Neuromorphic Systems at Western Sydney University aiming to be the most advanced yet, with the potential to perform 228 trillion actions per second.
How does a brain computer work?
DeepSouth uses an approach to computing that is inspired by the human brain and body, aiming to combine processing power and memory just like the human brain does. By distributing power to billions of tiny units (neurons) that interact through trillions of different connections (synapses), the brain becomes incredibly powerful while consuming very little energy.
What does this mean for the future of computers?
This approach could lead to significant improvements in energy efficiency and battery life for devices such as smartphones. It could also enable the development of smaller and more powerful computers, bringing high-powered computing to a variety of applications and industries.
How DeepSouth can help fight aging
While the primary goal of DeepSouth is to improve computing technology, the neuromorphic approach also offers insights into the workings of the human brain. This could lead to a better understanding of diseases such as Alzheimer’s, dementia, and Parkinson’s and potentially aid in developing treatments for these conditions.
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