Is Pulsar Light the Key to Solving the Dark Matter Mystery?

New research explores the possibility that dark matter is composed of theoretical particles called axions, and focuses on detecting them through additional light from pulsars. Although axions have not yet been confirmed in early observations, this research is critical to understanding dark matter.

A central question in the ongoing search for dark matter is: What is dark matter made of? One possible answer is that dark matter is made up of particles known as axions. A recent study by astrophysicists at the University of Amsterdam and Princeton University suggests that if dark matter is indeed made of axions, it could manifest itself in the form of subtle additional glow emanating from pulsating stars.

Dark matter may be the most sought-after building block in our universe. Remarkably, this mysterious form of matter, so far undetectable by physicists and astronomers, is thought to make up a huge portion of what exists on Earth. It is suspected that more than 85% of the matter in the universe is “dark”, and at the moment it is only recognized by the gravitational force it exerts on other celestial bodies. Naturally, scientists want to look directly detect its existence rather than just inferring it from gravitational effects. And of course they want to know what of course, solve two problems One thing is clear: dark matter cannot be the same kind of matter that makes up you and me. If so, dark matter would simply behave like ordinary matter. Dark matter will form star-like objects, will glow, and will no longer be “dark.” So scientists are looking for something new, a type of particle that no one has detected yet, and perhaps one that only interacts very weakly with the types of particles we know about.

One common hypothesis is that dark matter may be made of: Axion. This hypothetical type of particle was first introduced in the 1970s when he solved a problem that had nothing to do with dark matter. The separation of positive and negative charges inside a neutron, one of the building blocks of a normal atom, turns out to be unexpectedly small. Of course, scientists wanted to know why. It turns out that the presence of a previously undetected type of particle that interacts very weakly with components of neutrons can cause just such an effect. Frank Wilczek, who later won the Nobel Prize, came up with the name for this new particle. Axion – as well as similar to another particle name such as protons, neutrons, and electrons. photon, but it’s also inspired by the laundry detergent of the same name. Axion existed to solve problems. In fact, it might clean up the two even if it’s not detected. Several theories about elementary particles, including string theory, one of the leading candidate theories for unifying all the forces in nature, seem to predict the possibility of axion-like particles.

Fortunately, there appears to be a way out of this conundrum for axions. If the theory predicting axions is correct, not only would axions be expected to be produced in large quantities in the universe, but some axions could also be converted to light in the presence of strong electromagnetic fields. If there is light, we can see. Could this be the key to detecting axions and, by extension, dark matter? To answer this question, scientists first had to ask themselves where in the universe the strongest known electric and magnetic fields occur. The answer is known in the region around rotating neutron stars. pulsar. These pulsars (short for “pulsating stars”) are dense objects with a mass about the same as the Sun, but a radius about 100,000 times smaller, or only about 10 km. Because pulsars are so small, they rotate at enormous frequencies and emit bright, narrow beams of radio radiation along their axis of rotation. Just like a lighthouse pulsarThe beam can sweep across the Earth, making it easy to observe the pulsating star. But the pulsar’s massive rotation does more than that. it is, neutron star It turns into a very powerful electromagnet. That could mean Pulsar is a highly efficient axion factory. The average pulsar can produce 50 orders of magnitude axions per second. Because of the strong electromagnetic fields surrounding pulsars, some of these axions can be converted into observable light.

As always in science, carrying out such observations in practice is, of course, not so easy. The light emitted by axions (which can be detected in the form of radio waves) is only a fraction of the total light these bright cosmic lighthouses send back to us. Much less can we quantify the difference and turn it into a measurement of the amount of dark matter. This is exactly what a team of physicists and astronomers are currently doing. Through a collaboration between the Netherlands, Portugal, and the United States, the research team has uncovered details about how axions are created, how axions escape the neutron star’s gravity, and…

First observational tests were performed on the theory and simulation results…referencesystem, simulate a subtle glow

Next, first observational tests were performed on the theory and simulation results…referencesystem to show that it is very unlikely that axions are a component of…s

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Source: scitechdaily.com

COVID-19 can lie dormant in the lungs for as long as 18 months




SARS-CoV-2 Virus Persistence Study

The SARS-CoV-2 Virus Persistence Study

The SARS-CoV-2 virus can remain in the lungs for up to 18 months after infection, a study has found, challenging the notion that it is undetectable after initial recovery. This persistence is associated with a failure of the innate immune system. This study confirms the existence of “viral reservoirs” similar to those found in HIV and highlights the role of NK cells in controlling these reservoirs. This discovery is extremely important for understanding long-term COVID-19 infections and the mechanisms of viral persistence.

Groundbreaking research reveals:

SARS-CoV-2 Due to malfunctioning of the innate immune system, it can remain in the lungs for months, undetected, leading to long-term COVID-19 infections. 1 to 2 weeks after being infected with the new coronavirus (SARS-CoV-2) virus It is generally undetectable in the upper respiratory tract. But does that mean it’s not present in the body? To find out, a team at the Institut Pasteur, which specializes in HIV, teamed up with France’s public research institute, the Commission for Alternative Energies and Atomic Energy (CEA), to study lung cells in animal models. It was conducted. This finding not only shows that SARS-CoV-2 can be detected in the lungs of certain individuals for up to 18 months after infection, but also that its persistence is associated with a failure of innate immunity, the first line of defense against the pathogen. It also shows that this is the case. ).This study was published in the journal innate immunology.

Discovery of virus carriers in the new coronavirus infection (COVID-19)

After causing an infection, some viruses remain in the body in a discreet and undetectable form. They remain in what is known as the “viral reservoir.” This is the case with HIV, which is latent in certain immune cells and can reactivate at any time. The same may be the case with the SARS-CoV-2 virus. COVID-19 (new coronavirus infection). At least, this is the hypothesis proposed in 2021 by a team of scientists at the Pasteur Institute, and now confirmed in a preclinical model in non-human primates.

“We observed that inflammation persisted for a long time in primates infected with SARS-CoV-2. We therefore thought that the presence of the virus in the body could be the cause,” said Pass. explains Michaela Müller Tortwin, head of the HIV, Inflammation and Persistence Unit at the Toole Institute. This study showed that the SARS-CoV-2 virus is transmitted from one macrophage to another through bridge-like cell processes, allowing it to spread. The cell nucleus is highlighted in pink and the viral protein NSP3 is highlighted in green. Credit: © Marie Lazzerini, Nicolas Huot, Institut Pasteur research result To study the persistence of the SARS-CoV-2 virus, scientists at the Institut Pasteur collaborated with CEA’s IDMIT (Infectious Disease Models for Innovative Therapies) Center to study the persistence of the SARS-CoV-2 virus from animal models infected with the virus. The collected biological samples were analyzed. Early results from the study show that the virus was detected in some people’s lungs 6 to 18 months after infection, even though it was not detected in their upper respiratory tract or blood. Another finding was that the amount of residual virus in the lungs was lower with the Omicron strain than with the original SARS-CoV-2 strain. “We were really surprised that we found the virus in specific immune cells (alveolar macrophages) after such a long period of time, when routine PCR testing was negative,” said the study’s lead author. Yes, says Nicolas Huot, a researcher in HIV, inflammation and inflammation at the Institut Pasteur. Persistence unit.

“Furthermore, we were able to culture these viruses and use the tools we developed to study HIV to observe that the viruses were still able to replicate.” To understand the role of innate immunity in controlling these viral reservoirs, scientists next turned to NK (natural killer) cells. “The innate immune cellular response, the body’s first line of defense, has so far been little studied in the context of SARS-CoV-2 infection,” says Michaela Müller-Turtwin. “However, it has long been known that NK cells play an important role in controlling viral infections.” The study found that in some animals, macrophages infected with SARS-CoV-2 were destroyed by NK cells. In other animals, NK cells have been shown to adapt to infection and destroy resistant cells (known as adaptive NK cells). For macrophages. Therefore, this study sheds light on a possible mechanism explaining the existence of ‘viral reservoirs’. People who had little or no virus over time had adaptive NK cell production, whereas people with higher levels of virus not only had no adaptive NK cells, but only cell activation. NK cell activity also decreases. Therefore, innate immunity appears to play a role in controlling persistent SARS-CoV-2 virus.

Future research directions

“We will undertake a study of a cohort infected with SARS-CoV-2 early in the pandemic to investigate whether the identified viral reservoirs and mechanisms are associated with long-lasting COVID-19 cases. “However, the results here already represent an important step in understanding the nature of the virus reservoir and the mechanisms regulating virus survival,” says Michaela Müller-Turtwin.

Reference:

“SARS-CoV-2 virus persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells”, Nicolas Huot, Cyril Planchais, Pierre Rosenbaum, Vanessa Contreras, Beatrice Jacquelin, Caroline Petitdemange, By Marie Lazzerini, Emma Beaumont, Aurelio Horta-Rezendis, Felix A. Rey, R. Keith Reeves, Roger Le Grand, Hugo Mouquet, Michaela Müller-Tourtuin, November 2, 2023. innate immunology.

This research was primarily funded by families of major donors as part of the Coronavirus Research Program Call for Projects.


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Study uncovers long-term health hazards

New research reveals significant metabolic and health risks associated with long-term coconut oil supplementation, including hormonal changes, weight gain, and inflammation. Lead researcher Marcio Alberto Torsoni advises against consuming coconut oil blindly and recommends a moderate amount according to dietary guidelines.

Scientists at the State University of Campinas observed changes in eating patterns, weight gain, signs of anxiety, and increased inflammation in the brain, adipose tissue, and liver in mice.

Article published in Functional food journal We report on a research study in which oral administration of extra virgin coconut oil supplements to mice showed significant changes in eating habits, weight gain, anxiety levels, and inflammation in the central nervous system, adipose tissue, and liver.

Researchers also discovered that leptin, an important metabolic hormone, insulin The ability to activate cellular mechanisms involved in satiety and blood sugar control may be impaired, and biochemical mechanisms involved in fat synthesis may be stimulated.

Researcher insights

Marcio Alberto Torsoni, a researcher at the Institute of Metabolic Disorders, said: “The results of this study suggest that although the process occurs slowly and quietly, long-term coconut oil supplementation contributes to the development of obesity and related comorbidities. “This suggests that it may cause significant metabolic changes.” LabDiMe) is conducted at the Faculty of Applied Sciences of the State University of Campinas (FCA-UNICAMP), São Paulo State, Brazil. He holds a PhD in Functional and Molecular Biology and completed postdoctoral studies at the UNICAMP Faculty of Medicine and the University of Michigan, USA.

LabDiMe is part of the Obesity and Comorbidity Research Center (OCRC), one of FAPESP’s Research, Innovation, and Dissemination Centers (RIDCs), and the Center for Metabolic Programming and Perinatal Management (MPPM), which receives funding from the U.S. We are collaborating with National Institutes of Health (NIH (National Institutes of Health).

Animal fat and coconut oil risks

Excessive intake of animal fats is associated with an increased risk of: cardiovascular disease, as well as obesity and diabetes. One of the components of this diet is cholesterol, but this type of fat also contains saturated fatty acids, which can activate inflammatory processes through Toll-like receptor 4 (TLR-4) and cause disease. there is.

Saturated fatty acids are also available from other sources, such as plants. For example, it makes up 90% of the fat in coconut oil. Although short-chain fatty acids make up the majority and are beneficial as they reduce inflammation, the saturated fatty acids found in coconut oil are sufficient to activate inflammatory pathways and damage many different types of cells.

“Consumption of coconut oil, either as part of the regular diet or as a dietary supplement, has increased significantly in the population,” Torsoni says. The problem is that most of the time it is consumed without the guidance of a nutritionist who can adjust the daily intake according to the individual’s needs.

experimental model

To find out whether daily consumption of coconut oil over long periods of time could cause health problems, the research group used an animal model involving healthy mice that were given coconut oil daily for eight weeks. did. This amount of coconut oil is equivalent to about 1 soup spoon (13g) of calories per day, or 5% of the calories from saturated fat in the diet of an adult of appropriate weight for his or her age and height.

Torsoni said coconut oil should be used in small amounts as part of seasonings and sauces, preferably with fresh or minimally processed vegetables. This is also the advice of the Ministry of Health’s Dietary Guidelines for Brazilian Citizens, which also recommends “an appropriate and healthy diet that combines quantity and quality and meets the needs of variety, balance, moderation and enjoyment.” I am.

“Coconut oil is not recommended as a supplement to treat disease or restore health,” Torsoni says.

Reference: “CO 2 supplementation induces lipogenesis in adipose tissue, leptin and insulin resistance in healthy Swiss mice” Alana Carolina Costa Veras, Larissa da Silva Bruzasco, Ana Beatriz Profiro Lopes, Beatriz da Silva Franco, Written by Alessandro Spencer de Souza Holanda, Andrea Maculano Estevez, Marcian Milanski, Adriana Souza Torsoni, Leticia Martins Ignacio-Sousa, Marcio Alberto Torsoni, June 4, 2023. Functional food journal.
DOI: 10.1016/j.jff.2023.105600

This study was funded by the São Paulo Research Foundation.

Source: scitechdaily.com