There was a gigantic snake that used to inhabit India

A new genus and species of giant mazzoid snake that lived in what is now India about 47 million years ago (early mid-Eocene epoch) has been identified from part of a vertebral column excavated in the Indian state of Gujarat.

Artist’s impression Vasuki Indicus.

with scientific name Vasuki Indicus the new species flourished during a warm geological period when average temperatures were estimated to be 28 degrees Celsius.

the ancient snake Matzoidae an extinct group of primarily Gondwanan land snakes, spanning a time range of approximately 100 million years from the Late Cretaceous to the Late Pleistocene.

Paleontologists Debasjit Dutta and Sunil Bajpayee from the Indian Institute of Technology Roorkee said, “The Mazzoidae existed for about 100 million years, from the Late Cretaceous to the Late Pleistocene, and has a wide geographical range including Africa, Europe, and India.” “They lived in the area,” he said.

Vasuki Indicus “This represents a lineage of large matzoids that originated in the Indian subcontinent and spread through southern Europe to Africa during the Eocene epoch, approximately 56 to 34 million years ago.”

anterior trunk vertebrae Vasuki Indicus. Scale bar – 5 cm. Image credit: D. Datta & S. Bajpai, doi: 10.1038/s41598-024-58377-0.

A series of 27 well-preserved vertebrae from a fully grown animal. Vasuki Indicus It was recovered from the Panandro lignite mine, part of the Naledi Formation in Gujarat, western India.

The vertebrae are 3.75–6.3 cm (1.5–2.5 in) long and 6.24–11.14 cm (2.5–4.4 in) wide, suggesting a broad cylindrical body.

Vasuki Indicus Estimated lengths reach 11–15 m (36–49 ft), making this species the largest known mudsoid snake.

“This is comparable in size to the longest-living snake ever known, an extinct snake.” Titanoboa” said the researchers.

“The large size is Vasuki Indicus It was a slow-moving ambush predator, similar to an anaconda. “

“Biogeographical considerations, taken together with interactions with other Indian and North African madzoids, suggest that: Vasuki Indicus It represents a lineage of relics of Indian origin,” they added.

“The subsequent collision between India and Asia 50 million years ago led to intercontinental dispersal of this lineage from the subcontinent through southern Eurasia and into northern Africa.”

“Recovery of additional material and new species, including larger forms, may provide further insight into the phylogenetics and biogeography of madzoids.”

of study It was published in the magazine scientific report.

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D. Dutta and S. Bajpai. 2024. The largest known mudsoid snake lived in the warm Eocene of India, suggesting dispersal across Gondwana. science officer 14, 8054; doi: 10.1038/s41598-024-58377-0

Source: www.sci.news

The fruit fly Drosophila melanogaster employs multiple senses to detect surrounding scents.

Animals have various ways to detect chemicals in their environment, which differ depending on the species. Mammals use their tongues to taste, while fish and other aquatic creatures use their skin to taste. Insects, on the other hand, have taste buds not only inside their mouths but also outside their bodies.

Researchers have discovered that fruit flies, scientifically known as Drosophila melanogaster, have developed unique ways to utilize their senses of smell and taste to locate food and avoid dangers in diverse habitats. By exploring how fruit flies’ senses have evolved, scientists aim to uncover how these insects have adapted to their surroundings.

To study the sensory capabilities of fruit flies, researchers at the University of Lussanne in Switzerland compared the smells and tastes of different fruit fly species. They collected five essential body parts related to the flies’ senses: 1) larvae head, 2) egg-laying part, 3) front legs, 4) antennae, and 5) mouthparts with palpation structures. These body parts were collected from six closely related species of fruit flies living in various environments and consuming different diets.

The researchers separated male and female fruit flies into three replicates for each sex and species. They anesthetized the adult flies with CO2 to collect samples without causing harm. They separated larvae from their food source and removed their heads for analysis. This process was repeated three times for each body part of the adults, larvae, and egg-laying parts.

Using RNA sequencing technology, scientists examined the genes in different parts of the fruit fly’s body to understand how they respond to stimuli. This method helped identify active and inactive genes in various body parts, shedding light on how Drosophila adapts to its environment. The RNA data was stored in the Genomics Database for future research purposes.

The researchers observed that specific genes controlling smell and taste in fruit flies vary in their activation patterns. Changes in gene activity were influenced by factors like temperature, humidity, and interactions with other organisms. Differences in gene activity between male and female fruit flies were also noted, potentially impacting their mate selection.

The complexity of gene regulation in fruit fly sensory organs may vary across species and sexes, affecting their adaptation to diet and habitat changes. Further research is needed to understand the genetic basis of odor patterns in fruit flies and how it aids in their adaptation.

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Source: sciworthy.com

New Sponsor Boosts Sui Overflow Hackathon Funding Pool to $1 Million – Blockchain News, Opinion, TV, Jobs

Grand Cayman, Cayman Islands, April 22, 2024, Chainwire

Alibaba Cloud, AngelHack and dWallet are among the latest supporters of the global event.

SuiLayer 1 blockchain that delivers industry-leading performance and infinite horizontal scaling funds Sui Overflow, the first-ever global virtual hackathon focused on creating exciting products on Sui Our offering has doubled in recent weeks thanks to donations from our loyal supporters.

Originally set at $500,000, Sui Overflow's funding pool grew to $1,000,000 after a surge of support from outside backers. With the help of a huge reward pool, builders from all over the world come together to build projects on the Sui network and demo them in front of judges. Categories eligible for prizes include Consumer & Mobile, Infrastructure & Tools, Gaming, DeFi, and more. Developers are also encouraged to take advantage of specific technologies in the Sui ecosystem, such as zkLogin, advanced movement capabilities, randomness, and multi-chain capabilities.

Sam Blackshear, co-founder/CTO of Mysten Labs and creator of the Move smart contract language said: , Kiosks, DeepBook, and Native Randomness. Some of Sui's top projects have come from previous local hackathons, so we're really looking forward to seeing what our first global hackathon will produce. ”

Previous Sui-sponsored hackathons have been fertile ground for projects that started as hackathon participants to grow into sustainable businesses on the network. Scallop was launched in June 2023 at Sui's Soul Builder House with a…sumers are not limited to a single category. Individual teams can participate in multiple tracks simultaneously, with prize pools exceeding $100,000. Additionally, many projects in the Sui ecosystem offer unique incentives, adding even more ways for great projects and great teams to benefit.

With funding doubling to $1 million, Sui Overflow participants will receive Sui Foundation acceleration grants after the hackathon, along with benefits such as audits and credits to support the successful launch of their projects. be eligible to receive it.

“Homegrown projects born out of developer meetups and hackathons like Sui Overflow are a critical part of the lifeblood that will sustain the Su…ns, we were able to benefit the most promising projects with selected acceleration grants.”

“Sui Overflow is more than just an event. It is the launching pad for our brightest future blockchain innovators,” said Omer Sadika, co-founder of dWallet Network. “We are excited and honored to work with all partners involved and look forward to the results from this hackathon.”

Users can apply and developers can register Sui overflow portal Find all the details. We encourage everyone to join for regular updates. Discord server overflow.

Registration period:April 21st to May 31st

virtual demo day: June 15th.

Announcement of winners: Late June 2024

contact

Sui Foundation
media@sui.io

Source: the-blockchain.com

Biden announces $7 billion in federal funding for solar energy projects in celebration of Earth Day

WASHINGTON — THE PRESIDENT Joe Biden marked Earth Day by announcing $7 billion in federal grants for residential solar power projects serving more than 900,000 households in low- and moderate-income areas. He also plans to expand the New Deal-style U.S. Climate Change Corps Green Jobs Training Program.

The grants were awarded by the Environmental Protection Agency, with 60 recipients announced on Monday. Government officials expect the projects to reduce emissions by the equivalent of 30 million tons of carbon dioxide and save households $350 million a year.

Biden’s climate announcement is aimed at energizing young voters in his re-election bid. Young people played a key role in defeating then-President Donald Trump in 2020. They have shown interest in Biden’s climate policy and are eager to contribute through programs like the Climate Change Corps.

Solar energy is gaining popularity as a renewable energy source that can reduce dependence on fossil fuels and improve the power grid’s reliability. However, the initial installation cost of solar energy remains a barrier for many Americans.

The grants include 49 state-level grants, six grants for Native American tribes, and five multi-state grants. They can be used for investments in rooftop solar power generation and community solar gardens.

Biden made the announcement at Prince William Forest Park in northern Virginia, about 30 miles southwest of Washington. The park was established in 1936 by President Franklin D. Roosevelt as part of his Civilian Conservation Corps during the Great Depression.

Biden’s American Climate Corps, modeled after President Roosevelt’s New Deal, offers about 2,000 positions in 36 states, including partnerships with the Building Trades Union of North America.

The grants are part of the Solar for All program, funded by a $27 billion “green bank” established as part of a broader climate law initiative. The program aims to reduce climate change, air pollution, and support disadvantaged communities most affected by climate change.

EPA Deputy Administrator Janet McCabe expressed excitement about the funds benefiting communities, providing skills, creating jobs, and helping households save on utility bills.

Among the businesses receiving grants are nonprofit projects in West Virginia, solar leasing programs in Mississippi, and solar worker training programs in South Carolina.

Concerns remain about Republican opposition to taxpayer-funded green banks and accountability for how the funds are used. The EPA previously allocated the remaining $20 billion in bank funds to support clean energy projects in various organizations and communities.

Source: www.nbcnews.com

TikTok vows to resist US bans and forced sales following bill approval | Ticktock

TikTok has announced its intention to challenge any ban or requirement for the app’s sale in the United States through legal means, following the passing of a bill by the House of Representatives that targets the popular video platform.

Uncertainty looms over the company’s future in the United States after lawmakers in Washington approved a bill that would mandate the sale of a stake in TikTok’s U.S. operations by its Chinese parent company, ByteDance, or face a ban.

The bill, part of a foreign aid package for Ukraine, Israel, and Taiwan, was passed by the House with a vote of 360-58 on Saturday and will now be presented to the Senate for further consideration. President Joe Biden has expressed his support for the bill.

Michael Beckerman, TikTok’s head of public policy for the Americas, informed employees via a memo after the vote that the bill is deemed unconstitutional, and TikTok intends to challenge it in court.

Beckerman stated in the memo, initially reported by a technology news website, that the bill infringes on the First Amendment, which safeguards free speech rights, and vowed to pursue legal action once the bill is signed into law.

Arguments on the basis of the First Amendment have previously worked in TikTok’s favor in the U.S. In a ruling last year, a district judge in Montana blocked a state ban on TikTok, citing violations of users’ free speech rights. The judge found that the ban exceeded the state’s authority and violated constitutional rights.

TikTok has faced scrutiny from U.S. lawmakers and other Western officials, including those in the UK, over concerns that user data could be accessed by the Chinese government. While TikTok denies such requests from Beijing, critics fear ByteDance may be compelled to share data with Chinese security services under the country’s laws.

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TikTok is yet to provide a comment on the matter.

Source: www.theguardian.com

Australian court orders Elon Musk’s X to remove Sydney church stabbing post from global users

The Federal Court of Australia mandated that Elon Musk’s content be hidden from users.

X, along with Mehta, was instructed by eSafety Commissioner Julie Inman-Grant to promptly remove any material depicting “unreasonable or offensive violence with serious consequences or details” within 24 hours or risk facing fines.

The content in question was a video allegedly showing Bishop Mar Mari Emanuel being stabbed to death during a livestreamed service at the Assyrian Church of the Good Shepherd in Wakely.

Although X claimed compliance with the request, they intended to challenge the order in court.

During a hearing, eSafety barrister Christopher Tran informed Judge Jeffrey Kennett that X had geographically restricted access to the posts containing the video, rendering them inaccessible in Australia but available globally through VPN connections.

Tran argued that this noncompliance with online safety laws necessitated the removal of the content globally as an interim step.

X’s legal representative, Marcus Hoyne, requested an adjournment, citing the late hour in San Francisco where X is based and lack of instructions from his client.

Judge Kennett proposed issuing an interim order until the next hearing, requiring the post’s removal and global access blockage until a specified date and time.

Treasurer Stephen Jones criticized X as a “factory of trolls and misinformation” and affirmed the government’s readiness to combat legal challenges from the company.

The eSafety Commissioner clarified that the notice solely concerned the video footage and not any commentary surrounding the incident.

Prime Minister Anthony Albanese emphasized the harmful impact of violent content on social media and condemned X for noncompliance with the removal order.

Meta purportedly followed the directive, while X accused the regulator of “global censorship” and announced intentions to challenge the order in court.

Treasurer Jones vowed to challenge X’s stance, emphasizing the need for online platforms to adhere to laws and maintain safety.

Regulators collaborated with various companies, including Google, Microsoft, Snap, and TikTok, to remove the contentious content.

Opposition Leader Peter Dutton voiced support for eSafety’s actions and criticized X for considering itself above the law.

Green Party spokesperson Sarah Hanson-Young called upon Elon Musk to address the issue in parliament and urged tech companies to act responsibly.

This confrontation is the latest in the ongoing dispute between X and the eSafety Commissioner, which includes legal battles over compliance with safety regulations.

X faced legal action for allegedly bullying a trans man on Twitter, prompting the company to block access to the content in Australia, while filing a lawsuit challenging the decision.

Queries for comments from X remain unanswered.

Source: www.theguardian.com

Stunning images of small spiral galaxies captured by Hubble

Astronomers using the NASA/ESA Hubble Space Telescope have captured an excellent image of the spiral galaxy ESO 422-41 in the constellation Columba.

This Hubble image shows ESO 422-41, a spiral galaxy located in the constellation Columba, about 34 million light-years away. Image credit: NASA / ESA / Hubble / C. Kilpatrick.

ESO 422-41 It is located in the constellation Columba, about 34 million light years away.

DDO 230, LEDA 16864, or UGCA 103, the diameter of this spiral galaxy is 30,000 light years.

“The name ESO 422-41 comes from its appearance in the European Southern Observatory (B) Atlas of the Southern Sky,” Hubble astronomers said.

“In the era before automated sky surveys by space observatories such as ESA's Gaia satellite, large-scale photographic surveys discovered many stars, galaxies, and nebulae.”

“Astronomers used the then most advanced large telescopes to create hundreds of photographs covering parts of the sky.”

“They then studied the resulting photographs and attempted to catalog all the new objects revealed.”

“In the 1970s, a new telescope at ESO's La Silla facility in Chile probed the southern sky, which had not yet been explored as deeply as the northern sky,” they added.

“At that time, the primary technology for recording images was glass plates treated with chemicals.”

“The resulting collection of photographic plates became the ESO (B) Atlas of the Southern Sky.”

“Astronomers from ESO and Uppsala, Sweden, worked together to study the plates and recorded hundreds of galaxies (ESO 422-41 is just one of them), star clusters and nebulae. I was a beginner.”

“Since then, astronomical sky surveys have progressed from digital, computer-aided surveys such as the Sloan Digital Sky Survey (SDSS) and Legacy Survey to surveys performed by space telescopes such as Gaia and the Wide-Field Infrared Survey Explorer (WISE). It has transitioned to

“Nonetheless, photographic sky surveys have made significant contributions to astronomical knowledge over the decades, and the glass plate archive serves as an important historical reference for a wide range of skies. .”

“Some of them are still actively used, for example, to study variable stars over time,” the researchers pointed out.

“And the objects revealed by these surveys, including ESO 422-41, can now be studied in detail with telescopes like Hubble.”

The new images of ESO 422-41 consist of observations from Hubble's advanced survey camera (ACS) in the near-infrared and optical portions of the spectrum.

Two filters were used to sample different wavelengths. Color is obtained by assigning different hues to each monochromatic image associated with an individual filter.

Source: www.sci.news

Tesla experiences decrease in sales following a tumultuous week and global price reductions.

Tesla has reduced prices on three of its five models in the U.S. and globally, including in China and Germany, due to declining sales, a Cybertruck recall, and increasing competition in the electric vehicle market. The price cuts have affected the Model Y, Model X, and Model S, while the Model 3 and Cybertruck prices remain unchanged.

The Model Y now starts at $42,990, the Model S at $72,990, and the Model X at $77,990 following the price reductions. Tesla also slashed the price of its “fully self-driving” software in the U.S. from $12,000 to $8,000.

In China, the starting price of the updated Model 3 was reduced by 14,000 yuan ($1,930) to 231,900 yuan ($32,000). Meanwhile, in Germany, the price of the rear-wheel-drive Model 3 dropped to 40,990 euros ($43,670.75) from 42,990 euros.

The price cuts extend to many other countries in Europe, the Middle East, and Africa, as Tesla tries to boost sales following a decline in global car deliveries in the first quarter of the year.

The series of price reductions come amidst challenges for the company, including a Cybertruck recall due to issues with the gas pedal. This incident has added to Elon Musk’s recent troubles, with Tesla stock dropping and criticism from investors mounting.

Analysts are awaiting the release of the Model 2, a smaller electric car expected to cost around $25,000. Reports of Musk canceling the project have created uncertainty, but he has denied these claims.

Tesla is set to announce its first quarter results soon, with expectations of a significant drop in sales compared to the previous year, marking the first decline in quarterly sales in about four years for the company.

Contributed by Kari Paul report

Source: www.theguardian.com

Lawsuit filed against Grindr in London for exposing users’ HIV status to advertising firms

Grindr is potentially facing lawsuits from numerous users who allege that the dating app shared extremely confidential personal data with advertising firms, including disclosing their HIV status in some instances.

Law firm Austin Hayes is preparing to sue the app’s American owners in London’s High Court, claiming a breach of UK data protection laws.

The firm asserts that thousands of Grindr users in the UK had their information misused. They state that 670 individuals have already signed the claim, with “thousands more” showing interest in joining.

Grinder has stated it will vigorously respond to these allegations, pointing out that they are based on an inaccurate evaluation of past policies.

Established in 2009 to facilitate interactions among gay men, Grindr is currently the largest dating app worldwide for gay, bisexual, transgender, and queer individuals, boasting millions of users.

The lawsuit against Grindr in the High Court centers on claims of personal data sharing with two advertising companies. It also suggests that these companies may have further sold the data to other entities.

New users may not be eligible to take part, as the claims against Grindr primarily cover the period before April 3, 2018, and between May 25, 2018, and April 7, 2020. Grindr updated its consent process in April 2020.

Los Angeles-headquartered Grindr ceased passing on users’ HIV status to third parties in April 2018 following a report by Norwegian researchers uncovering data sharing with two firms. In 2021, Norway’s data protection authority imposed a NOK 65 million fine on Grindr for violating data protection laws.

Grinder appealed the decision from Norway.

The Norwegian ruling does not specifically address the alleged sharing of a user’s HIV status, recognizing that a user registered on Grindr is likely associated with the gay or bisexual community, making such data sensitive.

Chaya Hanumanjee, managing director at Austin Hayes leading the case, remarked, “Our clients suffer greatly when their highly sensitive data is shared without consent, leading to fear, embarrassment, and anxiety.”

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“Grindr is dedicated to compensating those impacted by the data breach and ensuring all users can safely utilize the app without fear of their data being shared with third parties,” Hanumanjee added.

The law firm believes that affected users might be entitled to significant damages but did not disclose details.

A spokesperson from Grindr stated, “We prioritize safeguarding your data and adhering to all relevant privacy regulations, including in the UK. Our global privacy program demonstrates our commitment to privacy, and we will vigorously address this claim.”

Source: www.theguardian.com

Exploring Online Stalking and Voyeurism: The Women of Manchester | Crime

Maddie Lane and Phoebe Colin were unaware of the cameras recording them as they strolled down a bustling street in Manchester last April.

On a warm spring day, the women sported brightly colored cycling shorts, completely oblivious to being surreptitiously filmed by a person with a device placed below waist level.

Colin expressed her discomfort upon watching the video, stating, “I don’t like it. You can see them zooming in on our butt cheeks.”

The perpetrator boldly shot a high-definition video, capturing them primarily from behind just a few meters away, before moving around to capture their faces, which were unmistakably visible.

Feeling violated, Lane mentioned, “I had no idea they were filming us. We were just wondering, ‘Why didn’t we notice them?’”

What intensified their fear was how they discovered the existence of the video. Lane received an Instagram message from an anonymous sender containing a link to the footage, insinuating, “Hi, is this you?” They proceeded to track down Colin and send her a similar message revealing the video’s online presence.

Lane shared their apprehension, saying, “The fact that they found us on social media was frightening. We still don’t know who they are.”

Despite reporting the incident to the police, there were no consequences. Colin recollected, “They informed us that there was nothing they could do and advised us to reach out if it happened again.”

The perpetrator appears to have filmed the two individuals in this video from close proximity. Photo: Joel Goodman/Guardian

This video is one among several targeting women in tight attire or short dresses, captured without their awareness in various UK towns and cities.

In response to the escalating issue, authorities urged women to report such incidents, emphasizing they would take a firm stand provided genuine victim or community reports were received.

Recent legislation has equipped the police with enhanced powers to seek stalking protection orders (SPOs) against offenders, aimed at curbing stalking behavior early on by prohibiting certain actions such as capturing images of perpetrators.

The changes announced by the Home Office on the first day of National Stalking Awareness Week enable police to apply for victim protection orders based on civil standards, simplifying the process by eliminating the need for conclusive criminal evidence.

The unsettling experience of Lane and Colin resonates with many women venturing out in Manchester on weekend nights, with similar incidents being common.

At popular venues like Printworks, incidents of secret video recordings have been reported, highlighting the urgent need for action and awareness.

The women at Deansgate, where numerous such videos circulated on social media, expressed concern over the pervasive issue of privacy invasion and objectification.

By sharing their thoughts and experiences, these women emphasized the importance of social change and actively confronting such reprehensible behavior.

Source: www.theguardian.com

Shaving your legs: a secret weapon for conquering the rush hour commute

Cyclists, from Team GB athletes to daily commuters, understand the importance of marginal gains. They constantly optimize their nutrition, equipment, and position to improve their race times by reducing drag.

It’s not surprising that some middle-aged men in Lycra (MAMILs) are considering shaving their legs. The idea is simple: removing leg hair can reduce drag, the force that slows down objects moving through the air. And on a bike, air resistance is the main factor that hinders speed.


When you’re cycling, the air in front of you moves as you move, creating wind resistance. To enhance aerodynamics, it’s crucial to optimize how the air flows around your body, reducing drag that holds you back. This is why cyclists wear skinsuits, position themselves low on the bike, and helmets are designed like sports cars.

There’s ongoing debate among riders and engineers about whether shaving your legs actually makes a significant difference in speed. An interesting study by a bicycle manufacturer tested shaved legs in a wind tunnel and found a 7 percent reduction in air resistance compared to natural legged riders.

In a 40 km time trial, this improvement could potentially give you a 79-second advantage over competitors. For professional riders, this could mean the difference between winning and losing.

This article addresses the question posed by Conrad Gordon via email: “Should I shave my legs if I love wearing Lycra and cycling?” If you have any questions, you can contact us at questions@sciencefocus.com or message us on Facebook, Twitter, or Instagram. Remember to include your name and location.

For more fascinating science content, check out our website for interesting information and more amazing science pages.

Source: www.sciencefocus.com

The Mystery of the Bermuda Triangle Solved by Science

The area of water between Florida, Puerto Rico, and Bermuda became notorious in the mid-20th century due to stories of mysterious disappearances of boats and planes.

A well-known incident occurred in 1945 when Flight 19, a group of five U.S. Navy bombers, vanished in the region. Over the years, wrecks and crashes in the Bermuda Triangle were often linked to supernatural forces.

In 1975, Larry Kush published a book debunking legends about the triangle, revealing inaccuracies and concluding that incidents in the area were not significantly higher than in other ocean regions.


Despite various theories proposed over the years, explanations range from natural phenomena like methane bubbles to supernatural causes like parallel worlds.

Some suggest that methane bubbles from the ocean floor caused ships to capsize, but research has shown no significant methane emissions in the area in the past 15,000 years.

The frequency of hurricanes in the region could have led to disasters before accurate weather forecasts were available, resulting in ships sinking due to high, rough waves.

While some blame magnetic anomalies for navigation errors, no such anomalies have been observed, though the alignment of true and magnetic north may have caused confusion in the past.

Despite the lack of identified dangers by the U.S. Coast Guard, and no statistically unusual number of incidents in the Bermuda Triangle, the mystery persists due to early reports receiving widespread attention.

Modern technology has enabled better tracking of air and sea traffic, reducing the sensationalism surrounding the Bermuda Triangle in recent years.

This article responds to the question posed by Cardiff resident Diane Johnston: “What happened in the Bermuda Triangle?”

For questions, email: questions@sciencefocus.com or message us on Facebook, Twitter or Instagram Page (include your name and location).

Explore more:

Source: www.sciencefocus.com

Fallout’s success shows that video game adaptations have become mainstream on TV.

IIn its initial days after release, Fallout, the Prime Video series based on the popular post-apocalyptic video game franchise, quickly became a global sensation. Topping the UK charts and ranking as one of the top three most-watched titles on Prime, it garnered widespread acclaim. This success led to Amazon announcing the renewal of the show for a second season within just one week of its global release across 240 countries and territories.

Amazon stated, “The expectations were high among fans of this iconic video game, and we are pleased to have exceeded them so far, attracting millions of new followers to the series.”

The triumph of Fallout, set two centuries after a nuclear catastrophe and featuring Ella Purnell, Kyle MacLachlan, and Aaron Moten, signifies the rise of video game adaptations into mainstream entertainment. Recent successes like HBO’s The Last of Us and The Super Mario Bros. Movie, which grossed $1.36 billion, highlight the increasing prominence of game-inspired content.

Rhys Elliott, a games industry analyst, compared game adaptations to superhero films, noting a shift towards gaming IP in Hollywood. The positive response to titles like Fallout and The Last of Us suggests a growing acceptance of gaming narratives in mainstream media.

Upcoming projects such as a Minecraft movie and a The Legend of Zelda adaptation by Margot Robbie reflect the industry’s evolving interest in gaming IP. The success of recent adaptations has debunked the myth of a curse surrounding game-to-film transitions, attributing it to faithful storytelling and star-studded productions.

Jonathan Nolan’s involvement in Fallout, driven by his passion for the game, underscores a new era where filmmakers appreciate the essence of gaming narratives. This collaboration between game developers and seasoned filmmakers has redefined the landscape of video game adaptations.

The shift towards gaming IP signifies a significant change in the industry’s approach to adapting video games. As Hollywood embraces this newfound gold rush, film studios are learning to leverage the global appeal of game franchises for successful adaptations.

Despite past misfires, recent successes have instilled confidence in the potential of video game adaptations. With a focus on engaging a broad audience and respecting the source material, these projects are redefining the narrative surrounding game-to-film transitions.

Source: www.theguardian.com

UK watchdog may thwart big tech companies’ ambitions for AI dominance.

“MMonopoly is Silicon Valley’s answer to Darth Vader and is “a condition of all successful business,” said Peter Thiel. This aspiration is widely shared by Valley giant Gamman, his new acronym for Google, Apple, Microsoft, Meta, Amazon, and Nvidia. And with the advent of AI, each one’s desire to reach that blessed state before others gets there is even greater.

One sign of their anxiety is that they are spending insane amounts of money on the 70-odd generative AI startups that have proliferated since it became clear that AI was going to be the new thing. Microsoft, for example, reportedly spent $13bn (about £10.4bn) on OpenAI, while leading a $1.3bn funding round for DeepMind co-founder Mustafa Suleiman’s startup Inflection. He was also an investor. Amazon invested $4 billion in Anthropic, a startup founded by refugees from OpenAI. Google invested $500 million in the same business, he pledged an additional $1.5 billion, and he invested an unknown amount in A121 Labs and Hugging Face.
(Yes, I know the name doesn’t mean anything.) Microsoft also invested in his French AI startup, Mistral. and so on. In 2023, only $9 billion of the $27 billion invested in AI startups was invested. From a venture capitalist company –Until recently, the company was by far the largest funder of emerging technology companies in Silicon Valley.

what’s happening? After all, the big tech companies have their own “fundamental” AI models and don’t need what smaller companies have built or are building. And every penny drops. We’ve seen this strategy before. An existing company discovers and captures potential competitors at an early stage. For example, Google acquired YouTube in his 2006. Facebook acquired Instagram for $1 billion in 2012 when it had only 13 employees, and WhatsApp in 2014 (for $19 billion, which seemed an exorbitant amount at the time).

With the 20/20 vision of hindsight, we now see that these were all anti-competitive acquisitions that should have been resisted at the time and were not. That’s why it’s so refreshing to know that at least one regulator, the UK’s Competition and Markets Authority (CMA), seems determined to learn from its history.

in Speech given at a gathering of American antitrust lawyers Just over a week ago in Washington, CMA CEO Sara Cardel called for ensuring the market for fundamental AI models is supported by fair, open and effective competition and strong consumer protections. announced that he had decided to do so. Her concern is that the growing presence of a few large incumbents across the AI ​​value chain (the series of steps required to turn inputs into usable outputs) will undermine competition and limit companies’ options. This meant that there was a possibility that these markets could be formed in a way that degraded quality. and consumers.

She cited three major risks to competition. One is that companies that control critical inputs for developing the underlying model may restrict access to protect themselves from competition. Powerful incumbents may exploit their positions in consumer and business markets to limit competition in model deployment and thereby distort choice. And we believe that partnerships between key players have the potential to strengthen or expand existing market power across the value chain.

He also said the CMA would take action to assess and mitigate competition risks from new technologies through its formidable investigatory powers, including merger control reviews, market investigations and possible designations under new digital competition laws. I warned you.

It was truly amazing to hear a major regulator speak like this about the technology industry. Cardel said the CMA will be a technology industry that believes in being proactive and (as is often said) moving quickly to break things, rather than waiting for problems to arise before acting. He suggested that he would try to stay ahead of the big players rather than lag behind them. He said the CMA is already preparing for this task based on what it has learned so far from adapting to technology platforms. Rather than focusing only on individual parts of the chain, the value of AI model deploymenthe aims to look at the entire chain holistically. It also plans to use its merger review powers more aggressively to assess the impact of alliances and AI investments on competition.

Isn’t that exciting? But in some ways it is no surprise as it is one of the few British institutions that seems able to use the post-Brexit freedoms as an opportunity for creativity and innovation. And bigwigs who are tempted to dismiss Cardel’s speech as mere fiery rhetoric should reflect on the CMA’s recent track record. A thorough investigation into Microsoft’s acquisition of Activision Blizzard, for example; or how Meta forced the sale of Giphy, an online database and search engine that allows users to find and share animated GIF files. Cardel may be lower profile than her U.S. FTC counterpart Lina Khan, but it’s clear she means business. People with strong possessiveness should be careful.

Source: www.theguardian.com

UK Case Ruling Prohibits Sex Offenders from Utilizing AI Tools

A convicted sex offender who created over 1,000 indecent images of children has been forbidden from using any “AI creation tools” for the next five years, marking a significant case in this realm.

Anthony Dover, 48, was instructed by a British court in February not to use artificial intelligence-generated tools without prior police authorization, as part of a sexual harm prevention order issued in February.

The prohibition extends to tools like text-image generators that produce realistic-looking photos from written commands, as well as the manipulation of websites used to generate explicit “deepfake” content.

Mr. Dover, who received a community order and a £200 fine, was specifically directed not to utilize the Stable Diffusion software known to be exploited by pedophiles to create surreal child sexual abuse material.

This case is part of a series of prosecutions where AI-generated images have come to the forefront, prompting warnings from charities regarding the proliferation of such images of sexual abuse.

Last week, the government announced the creation of a new crime that makes it illegal to produce sexually explicit deepfakes of individuals over 18 without their consent, with severe penalties for offenders.

Using synthetic child sexual abuse material, whether real or AI-generated, has been illegal under laws since the 1990s, leading to recent prosecutions involving lifelike images produced using tools like Photoshop.

These tools are increasingly being used to combat the dangers posed by sophisticated synthetic content, as evidenced by recent court cases involving the distribution of such images.

The Internet Watch Foundation (IWF) emphasized the urgent need to address the production of AI-generated child sexual abuse images, warning about the rise of such content and its chilling realism.

Law enforcement agencies and charities are working to tackle this growing trend of AI-generated images, with concerns rising about the production of deepfake content and the impact on victims.

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Efforts are underway to address the growing concern over AI-generated images and deepfake content, with calls for technology companies to prevent the creation and distribution of such harmful material.

The decision to restrict adult sex offenders from using AI tools may pave the way for increased surveillance of those convicted of indecent image offenses, highlighting the need for proactive measures to safeguard against future violations.

While restrictions on internet use for sex offenders have existed, limitations on AI tools have not been common, underscoring the gravity of this case and its implications for future legal actions.

The company behind Stable Diffusion, Stability AI, has taken steps to prevent abuse of their software, emphasizing the importance of responsible technology use and compliance with legal guidelines.

Source: www.theguardian.com

Gameboy: A Portal to Other Magical Realms at 35 Years Old

On April 21, 1989, Nintendo released a chunky gray gameplay rectangle for Japanese stores. It’s safe to say that no one expected much of it. Inside Nintendo’s Kyoto headquarters, the portable console was reportedly not a very popular project. However, within two weeks, the initial production run of 300,000 units had all been sold out. The Game Boy was released in the United States later that year, and would be released around the world over the next few years. We’ve found it to be equally popular wherever we go. Thirty-five years later and nearly 120 million units later, it remains the fourth best-selling gaming console of all time.

Like Sony’s Walkman, the Game Boy was an icon of technological design at the time, and is still instantly recognizable just by its silhouette. Developed by a team led by Satoru Okada and Gunpei Yokoi in Kyoto, the Game Boy was probably inspired by Yokoi’s dictum of “lateral thinking through dead technology” – do more with less, which continues at Nintendo to this day. This is an outstanding example of the technical principle of doing. It has a very simple design with four buttons and a cross-shaped D-pad, so it’s easy to use just by looking at it. Thanks to the grayscale screen, the battery lasted for several days of play. And, most importantly for the accident-prone kids of the ’90s (and their parents), you can throw this thing off a bridge and it’ll probably still work.

Gunpei Yokoi’s design principles made the Game Boy an international phenomenon. Photo: Associated Press

The Game Boy wasn’t the first handheld game console, nor was it the best game console at the time. Even in the late 80’s, it had a thick, retro feel. That screen didn’t have a backlight, but it was also sensitive to glare from bright sunlight, so I had to crawl across the screen to find the perfect amount of light (or use a large square I had to buy a portable lamp. more battery). Meanwhile, the Atari Lynx and Sega Game Gear arrived soon after with much better hardware and color graphics.


But it was the Game Boy that was the bestseller, spawning direct and spiritual successors from the Game Boy Color and Game Boy Advance to the Nintendo DS and even its Switch. These are all consoles that you can hold in your hand. The reason is that, unlike its rivals, it had an extraordinary game whose vibrancy went beyond the scope of its small gray-green screen.

The most memorable of these is definitely Tetris. Tetris wasn’t made specifically for Nintendo’s small console – it’s been playable on computers since 1984 – but it turns out the Game Boy was made for Tetris. Alexey Pajitnov’s shape slot puzzle game has found its perfect home on this small console. Its rudimentary graphics abilities were sufficient to render some configurations of falling blocks. In the US and Europe, the Game Boy was bundled with the game. So when you think of Tetris’ Earworm theme song, the bleeppy 8-bit Game Boy version of him probably comes to mind.

Block Rocking Blocks: Tetris battles have become a holiday staple for many families. Photo: Boston Globe/Getty Images

You can even play Tetris with friends, as there’s a port on the side that lets you connect your console with a cable, the Game Boy’s most advanced feature. This is what inspired Satoshi Tajiri, a quiet programmer who had a childhood interest in insects, to create Pokemon, the Game Boy’s most enduring game. From pixels and pure imagination, Pokémon has created a world full of distinctive creatures that kids and adults alike can lose themselves in and swap and battle over Link’s cables. Despite being released towards the end of the Game Boy, it became a phenomenon.

How a geeky little game like this – Pokemon battles are primarily about numbers and type matchups – became the single most profitable entertainment franchise on the planet, surpassing Mickey Mouse and Star Wars. is incredible to me. This is a testament to the creative vision of the creator, as well as the imagination of his 90s children, who did not suffer from elementary expressions. But it also teaches us about the power and intimacy of handheld gaming consoles. With television, games were rooted in the living room or bedroom. On the Game Boy, it became part of family vacations, long car trips, and lunch breaks at work. Games have become part of everyday life.

This handheld console spawned many hit series. Photo: Nintendo

Perhaps this is what helps games like Super Mario Land and the heartbreaking, otherworldly The Legend of Zelda: Link’s Awakening stay alive in the memories of those who play them. I remember we played Zelda on the commuter train. I met lifelong friends at my first job. After school, I got together with my friends at the playground and played Pokemon. On my day off, I played Tetris and had a high score competition with his older brother. Many people still have their Game Boys sitting in drawers or boxes in the attic. Their emotional value is so high that people can’t bring themselves to throw them away.

Here’s a favorite photo of four kids with bowl cuts from the ’90s crowd around women I was concentrating on my Game Boy. You can almost see the cartridge inside. It’s Super Mario Land. As far as I know, the origin of this photo is lost to time, but I’d like to think it’s her Game Boy, and she teaches the kids how to get past one of its more difficult levels. This image, for me, perfectly sums up this console and what it feels like to play it. Gameboys were shared by families and played by everyone, girls and boys, men and women. It was a portal to other small worlds and introduced millions of people to the magic of gaming.

Source: www.theguardian.com

Charity warns that UK children are facing a relentless onslaught of gambling advertisements and images online

New research has discovered that despite restrictions on advertising campaigns targeting young people, children are being inundated with gambling promotions and content that resembles gambling while browsing the internet.

The study, commissioned by charity GambleAware and funded by donations from gambling companies, highlights the blurred line between gambling advertising and online casino-style games, leading to a rise in online gambling with children unaware of the associated risks. It warns that gambling advertisements featuring cartoon graphics can strongly attract children. Recently, a gambling company promoted a new online slot game on social media using a cartoon of three frogs to entice players.

GambleAware is recommending new regulations to limit the exposure of young people to advertising. Research conducted by the charity revealed that children struggle to differentiate between actual gambling products and gambling-like content, such as mobile games with in-app purchases.

Zoe Osmond, CEO of GambleAware, emphasized the need for immediate action to protect children from being exposed to gambling ads and content, stating, “This research demonstrates that gambling content has become a part of many children’s lives.”

GambleAware chief executive Zoe Osmond said urgent action on internet promotions was needed to protect children. Photo: Doug Peters/Pennsylvania

The report also points out that excessive engagement in online games with gambling elements, like loot boxes bought with virtual or real money, can fall under a broader definition of gambling. It calls for stricter regulation on platforms offering such games to children.

Businesses are cautioned against using cartoon characters in gambling promotions, as they may appeal to children. However, there is no outright ban on using such characters. Online casino 32Red, for instance, recently advertised its Fat Frog online slot game on social media with a cartoon frog theme.

Dr. Raffaello Rossi, a marketing lecturer focused on the impact of gambling advertising on youth, criticized regulators for not acting swiftly enough to address the proliferation of online promotions enticing children. He called for new advertising codes to regulate social media promotions effectively.

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The Gambling and Gambling Council assured that their members strictly verify ages for all products and have implemented new age restriction rules for social media advertising.

Recent data from the Gambling Commission indicates that young people are now less exposed to gambling ads compared to previous years. While no direct link between problem gambling development and advertising has been established.

The Advertising Standards Authority (ASA) stated that it regulates gambling advertising to safeguard children and monitors online gambling ads through various tools and methods.

The Department for Culture, Media and Sport affirmed its focus on monitoring new forms of gambling and gambling-like products, including social casino games, to ensure appropriate regulations are in place.

Kindred Group, the owner of the 32Red brand, was reached out to for comment.

Source: www.theguardian.com

Half of all fruits and vegetables are now contaminated with the “forever chemical” – what are the implications?

The presence of PFAS (per- and polyfluoroalkyl substances), commonly known as “forever chemicals,” has been reported in various locations, including more than half of fruit and vegetable samples tested in the UK. This has led to increasing calls for the ban of pesticides containing these chemicals. But what are the health risks associated with consuming fruits and vegetables containing PFAS?

Understanding “Forever Chemicals”

PFAS are not a single chemical but a group of over 10,000 compounds with strong carbon and fluorine bonds. Examples include PFOS, PFOA, and PFHxS. These chemicals are used in the production of textiles, food packaging, nonstick surfaces, and pesticides due to their stability against heat, oil, and water. However, their poor biodegradability allows them to persist in the environment and human bodies for extended periods.


The Health Risks of PFAS

Ongoing research suggests that high exposure to certain PFAS compounds may lead to health issues such as increased cholesterol levels, thyroid and liver function impairment, adverse pregnancy outcomes, and a higher risk of certain cancers. While some governments have imposed restrictions on PFAS use, complete bans are rare as risks vary based on factors like exposure levels and individual health characteristics.

It’s essential to note that not all PFAS chemicals pose the same health risks, and exposure to high doses is typically required to observe harmful effects. Monitoring of PFAS levels in food is critical, with most samples in the UK containing PFAS below legal limits.

Reducing Risk and Ensuring Safety

Eating a diverse diet rich in fruits, vegetables, and grains can help reduce PFAS absorption and accumulation in the body. Washing produce thoroughly and peeling where necessary can also lower pesticide residue intake. While organic farming may reduce the presence of detectable residues, PFAS can still be found in organic produce due to environmental contamination.

Choosing locally grown, seasonal foods can further limit pesticide exposure and promote sustainable farming practices. It’s crucial to continue researching PFAS and other potentially harmful chemicals while also exploring safe and efficient methods for food production to sustain global food needs.

It’s important to approach food safety with caution, avoiding unnecessary fear or sweeping generalizations. While risks exist, proper awareness and informed choices can help mitigate potential health hazards associated with PFAS and other chemicals.

Source: www.sciencefocus.com

‘Martha Lane Fox: From Overachiever to Mountain Conqueror’

Even for able-bodied climbers, climbing Britain's three highest peaks can seem like a test of determination. But Martha Lane Fox has undergone 47 surgeries and suffers from impaired balance, nerve damage, and constant pain, requiring two canes to get anywhere. This is a remnant of the car accident that almost killed her 20 years ago.

On Saturday, she completed the first leg of “Martha's Mountain Mission” by reaching the summit of Snowdon or Yul Wiffa. Scafell Pike, England's highest mountain, will be next on May 6th, followed by Ben Nevis on September 7th.

“My body is not like other people's,” she said. observer. “I suffer from severe pain and incontinence and have very severe nerve damage. So all of these things make it a very big hurdle for me to try to walk for any length of time, let alone really long. Not to mention the hours going uphill and all the way back down.”

Martha's Mountain Mission marks the 20th anniversary of Lane Fox's car accident in Morocco. She's 31, just sold lastmount.com, the travel and gift company she founded with Brent Hoberman seven years ago, and is on vacation with her boyfriend of six weeks, Chris Gorrell Burns.

When Lane Fox was thrown from the passenger seat of a convertible and landed on a rock, it seemed like a new chapter in her life was about to end.

“I almost died,” she said in a low voice. “When you walk into the trauma room on the scale, they score you. I think up to 39 – 39 is dead. I was 37 at the time. So you can't get any closer to death. I don't think I could, and I was very, very hurt.

“But I was very lucky to be able to escape from Morocco first. It wasn't planned by me, my family planned it. Then I went to work at one of the best hospitals in the country, John – He was taken to Radcliffe Hospital. [in Oxford]is reinstated, then transferred to other hospitals over the next few years, and then continually reinstated.

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“So most people who go through something like that don't have all of that available to them.”

That's one reason she's walking. to raise her £300,000 for four charities. first day trauma This is for people in Lane Fox's situation, helping people with catastrophic injuries rebuild their lives. There are countless decisions to be made about treatment, finances, and what you need to do to recover. “So when I have a bad moment, I especially think of the Day One Trauma people.” [to motivate me],” she said.

Lane Fox broke 28 bones, suffered a stroke and was hospitalized for just under two years, as surgeon after surgeon tried to fix or simply alleviate her injuries. For the past 20 years, she has been in and out of hospital, and this is the inspiration for another charity she supports. horatio's garden.


On Saturday, friends will join the Martha Lane Fox in Eriri National Park (Snowdonia). Photo: Courtesy of Martha Lane Fox

“They are building beautiful gardens and spaces in each spinal unit for people like me who are stuck in the hospital for a very long time and can’t go outside,” she said. “When something like that happens, it doesn't really end. It changed my life forever. I'm lucky. I mean, in my heart, I'm not kidding. I'm lucky. I have the resources and support to survive and thrive. So I feel lucky.”

Thanks to their support, Lane Fox was able to build on its success during the dot-com boom and indeed grow. Three years after her accident, she joined the board of Marks and Spencer, was appointed to the House of Lords, and worked with David Cameron's government to improve computer literacy.

Another charity activity is ability net. This is a reminder for us to work with developers and technologists to remember older people and people with disabilities who are often excluded from digital life. Fourth, i am the code wants to help 1 million girls and young women become programmers by 2030.

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Lane Fox became Chancellor of the Open University in 2014 and had twin sons through surrogacy with Gorrell Barnes in 2016. Seven-year-olds Milo and Felix joined their girlfriend, along with more than 30 friends, on a run up and down Snowdon yesterday.

Still, the effects of her injury continue. “I do a lot of physical therapy anyway, because otherwise I wouldn't be able to exist,” she said. “But 2022 was a really bad year for me. I had sepsis and almost lost my leg. I was really sick, I was back in the hospital a lot.” Last year At 50 years old, she had only one ambition. That means she doesn't have time to be hospitalized.

“It made my mind clear. I wanted to do something so scary that it felt like a goal I had achieved, but at the same time something so scary that people might give me money. That's why I came up with the now somewhat crazy idea of ​​climbing these three peaks. ”

After spending Saturday in Wales in the cold April sun, a weary Lane Fox was looking ahead to his next two challenges.

“It was much harder coming down, but I'm alive, and I’m so happy every day,” she said.

“Ben Nevis is the hardest. But one thing at a time.”

To donate to Martha's Mountain Challenge, please visit: givewheel.com

Source: www.theguardian.com

What makes the “headless chicken monster” a deep-sea ninja that survives on poop?

Sea cucumbers are related to sea urchins and starfish. They typically rest on the ocean floor and are not very active, similar to plants. However, in the deep sea, sea cucumbers exhibit different behaviors.

Resembling the twirling skirts of flamenco dancers, the Spanish Dancers are transparent ruby-red creatures that gracefully swim and float with the ocean currents in the deep sea, wearing their webbed cloaks. Also known as the “Remarkable Dreamer” (Enypniastes excimia).

They also have a more grotesque alias: the headless chicken monster. It looks like a plucked chicken carcass tossed into the sea and can grow up to 25cm (9 inches) long. The part that resembles a neck after decapitation is actually its mouth, surrounded by feeding tentacles. When it settles on the ocean floor, it uses its tentacles to scoop sediment into its mouth.


Like other sea cucumbers, they feed on marine snow, which is a shower of organic debris sinking from the ocean surface. It includes dead plankton and their feces bound together by a sticky microbial glue.

This swimming sea cucumber was discovered in the 1870s by scientists on a Royal Navy battleship during the famous ocean expedition known as the Challenger. They inhabit all oceans, including near Antarctica, at depths ranging from 500 meters (1,600 feet) to at least 6,000 meters (about 19,600 feet).

Due to their high water content, they are fragile, and collecting specimens often damages them. To observe them live, scientists rely on remote-controlled deep-diving robots with video cameras to get a clear picture of their appearance this century.

Thanks to their hydrated bodies, they have neutral buoyancy, enabling them to swim without much effort. This is a vital survival strategy in the deep sea where food is scarce.

Through their see-through bodies, you can see their coiled digestive tract filled with pale sediment. Before propelling into the water column, they expel their cleaned sediment waste, similar to dropping ballast sandbags from a hot air balloon.

By mixing and aerating the ocean floor, they contribute to the ecosystem like earthworms do on land. They can also illuminate their bodies, which helps them navigate in the dark.

When threatened, their skin glows and flakes off, acting as a warning signal to predators. Lab studies showed that they can quickly regenerate their skin and retain their glowing ability.

If you have any questions, please email us at: questions@sciencefocus.comor send us a message Facebook, Xor Instagram Page (remember to include your name and location).

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Source: www.sciencefocus.com

The wildflowers and lakes of Death Valley showcase a dramatic contrast in climate

According to climate scientists, the impact of global warming on California’s interior is becoming more evident as desert droughts worsen and rainfall intensifies. Residents of Death Valley are witnessing these changes firsthand. The future of this resilient symbol lies in the ability of the desert’s plants, animals, and local economies to adapt to the evolving conditions in one of the Earth’s harshest environments.

“It’s fascinating to witness these changes up close,” remarked Donnelly. “It’s a clear indication of climate disruption.”

Two Unprecedented Storms

Susan Sorrels, who owns an ecotourism town near Death Valley National Park called Shoshone, described the weather in the area as always erratic. However, recent years have shown a distinct pattern. In early 2022, Death Valley, along with the rest of the American Southwest, experienced a historical drought lasting 22 years, leading to record-low soil moisture levels and the gradual demise of plants such as creosote bushes. The severity of these conditions was a testament to the extreme weather in the region.

“Desert shrubs are incredibly resilient but eventually succumb,” explained Lynn Sweet, a research ecologist at the University of California, Riverside.

In August of the same year, the region was struck by an unprecedented flood, receiving 1.7 inches of rain within a few hours. This storm caused significant damage to park infrastructure and left a lasting impact on the area.

About a year later, the remnants of Hurricane Hillary caused another extraordinary event, dumping 2.2 inches of rain in a day, exceeding the typical annual rainfall. This extreme shift from drought to heavy rainfall exemplifies the unpredictability of the changing climate.

Road workers work along Highway 190, where much of the road was washed away by Tropical Storm Hillary the week before, in Death Valley, Aug. 31, 2023.
Robert Gauthier/Los Angeles Times via Getty Images File

The aftermath of these storms led to challenges for Sorrels and her ecotourism business in Shoshone, with highway closures impacting accessibility during the peak tourist season.

Sorrels mentioned the local struggle to navigate through the economic impact of these weather fluctuations. She highlighted community efforts to expedite road repairs, ultimately reopening the park and highway for visitors.

In a surprising turn of events, Donnelly observed the growth of wildflowers in the region despite adverse conditions. The flowers, thriving in unusual ways, showcased a resilience that defied expectations.

Additionally, the presence of enough water led to the revival of Lake Manly, previously a dry lake bed filled with dust. This resurgence prompted the National Park Service to allow kayaking on the lake, a rare occurrence that highlighted the dramatic changes taking place in the region.

Source: www.nbcnews.com

Debunking the Multivitamin Myth: How Pills May Hurt Your Immune System

The immune system is a complex network of cells, proteins, and organs that acts as the body’s last line of defense against infection. Maintaining a healthy immune system is crucial for overall well-being.

While there are numerous supplements and products available to boost immune function, it’s important to understand that the immune system is a well-regulated system that typically functions optimally when you lead a healthy lifestyle.

Misconceptions about increasing immunity

Boosting immunity may seem like a good idea in theory, but in reality, the immune system is equipped to function efficiently on its own with the right lifestyle habits.

Attempting to supercharge the immune system with supplements can have negative consequences, as excess immune cells can lead to autoimmune diseases and other health issues.

According to Dr. Bobby Cherail, an expert in immunology, living a healthy lifestyle through proper diet, exercise, and avoiding harmful habits is the best way to support the immune system.

It’s important to note that the immune system may weaken with poor lifestyle choices, but infections typically occur only in extreme cases of malnourishment or deficiency.

Potential risks of vitamin supplements

While vitamin supplements may seem like a harmless way to boost immunity, there are risks associated with overconsumption of certain vitamins, such as vitamin A, D, E, and K.

Excess water-soluble vitamins are generally excreted by the body, but fat-soluble vitamins can accumulate and lead to toxicity if consumed in excess.

Studies have shown that multivitamins may not provide significant health benefits and can lead to a false sense of security, causing individuals to neglect other aspects of their health.

Long-term use of multivitamins has been linked to an increased risk of certain health conditions, especially in older individuals.

Vitamins still play a role…for some people.

While a healthy lifestyle is typically sufficient for maintaining a strong immune system, certain individuals with vitamin deficiencies may benefit from supplements.

People with difficulty chewing, swallowing, pregnant women, and those with digestive issues may require additional vitamin support to maintain optimal health.

Ultimately, the immune system is a highly efficient self-regulator, and for most people, immune-boosting supplements may not offer significant benefits.


About our expert Bobby Shereyle

Dr. Bobby Cherail is an associate professor of pediatrics at Harvard University, specializing in immunology and the immune system’s response to infection and inflammation.

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Source: www.sciencefocus.com

Determining the Limits: How Should AI be Used in TV and Film? | Culture

TWhile last year’s Hollywood writers and actors strike was about a variety of factors, among them fair pay and back pay, one concern far outweighed the others. It was a breach of a type of generative AI that can generate text, images, and video. people’s lives. It was a foregone conclusion that we would use generative AI in the content we watch, from movies to television to tons of trash on the internet. Pandora’s box has been opened. But the cry at the time was that even with a three-year contract, this technology was developed, deployed and deployed so quickly that protections were ensured against companies using AI to cut corners. If they did, it would be a victory.



It was no fuss. In the mere months since the Writers Guild and Actors Guild signed a historic deal with the Alliance of Motion Picture and Television Producers (AMPTP), the average social media user has almost certainly become aware of AI, whether they realize it or not. You will have encountered the generated material. Efforts to curb celebrity porn AI deepfakes have even reached the notoriously recalcitrant and insensitive US Congress. The internet is currently rife with misinformation and conspiracies, and with the presence of generative AI; Tore what was left of our shared reality to shreds., Kate Middleton’s AI deepfake video seemed like a not-unreasonable conclusion to many. (For the record, it was real.) Hollywood executives are already testing OpenAI’s upcoming text-to-video program, Sora, and producer Tyler Perry said: canceling his studio’s $800 million expansion Because “jobs will be lost” in Atlanta.

In short, many people are scared, or at best wary, and with good reason. That’s all the more reason to focus on the small battles over AI, rather than through an apocalyptic lens. Because amidst all the big talk about Taylor Swift deepfakes and the potential job apocalypse, generative AI is creeping into movies and TV in small ways, some potentially creative, some latent. Because it’s unlucky. In recent weeks alone, many examples of AI being used legally in and around creative projects have tested what audiences pay attention to and receive, and what is ethically acceptable. We are investigating.

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Close-Up View of Io’s Unique Features Captured by NASA’s Juno Mission

In December 2023 and February 2024, NASA’s Juno spacecraft will fly extremely close to Jupiter’s volcanic moon Io, coming within about 1,500 kilometers (930 miles) of the surface and obtaining the first close-up images of the moon’s northern latitudes. Planetary scientists have now turned images collected during the flight into animations that show two of Io’s most dramatic features: its mountains and a nearly glassy rock formed by cooling lava called Loki Patera. It emphasized the smooth lake.

The JunoCam instrument aboard NASA’s Juno spacecraft imaged Io, the most geologically active object in the solar system, on February 3, 2024, from a distance of approximately 7,904 km (4,911 miles) . Image credit: NASA/SwRI/MSSS.

“There are only a few scattered volcanoes on the island of Io, and we captured some of them active,” said Juno principal investigator and Southwest Research Institute cosmologist. said Scott Bolton, director of science and engineering.

“We also obtained great close-ups and other data about a 200 km (127 mile) long lava lake called Loki Patera.”

“It shows in amazing detail how these crazy islands are embedded in the middle of a potential magma lake fringed with hot lava.”

“The specular reflections that our instruments record about the lake suggest that parts of Io’s surface are glass-smooth, reminiscent of the obsidian glass produced in volcanoes on Earth. “

Map generated using data collected by Juno microwave radiometer (MWR)’s instruments revealed that Io not only has a relatively smooth surface compared to Jupiter’s other Galilean moons, but also has poles that are colder than the mid-latitudes.

During Juno’s long-term mission, the spacecraft will fly closer to Jupiter’s north pole with each pass.

This change in direction allows the MWR instrument to improve the resolution of Jupiter’s polar cyclones.

This data allows us to compare multiple wavelengths at the poles and reveals that not all polar cyclones are created equal.

“Perhaps the most striking example of this difference is seen in the central cyclone at Jupiter’s north pole,” said Dr. Steve Levin, Juno project scientist and researcher at NASA’s Jet Propulsion Laboratory. states.

“Although clearly visible in both infrared and visible light images, the microwave signature is not as strong as other nearby storms.”

“This indicates that its subsurface structure must be very different from other cyclones.”

“As the MWR team continues to collect more and better microwave data in every orbit, we expect to develop more detailed 3D maps of these interesting polar storms.”

Source: www.sci.news

454 new asteroids discovered in the main asteroid belt by astronomers

632 main-belt asteroids (178 known objects and 454 unknown objects) have been identified in archival images from the NASA/ESA Hubble Space Telescope. Citizen scientists from around the world contributed to the discovery of this asteroid. Professional astronomers identified the asteroid using a combination of volunteer efforts and machine learning algorithms.

This Hubble image of barred spiral galaxy UGC 12158 looks like someone took it with a white marking pen. In reality, this is a combination of long exposures of a foreground asteroid moving within Hubble's field of view, adding light bombardment to observations of the galaxy. The galaxy was photographed several times. The dashed pattern is proof of this. Due to parallax, the asteroid appears as a curved trajectory. Hubble is not stationary, but orbits around the Earth, giving the illusion of a faint asteroid swimming along a curved trajectory. This unknown asteroid is located inside the solar system's asteroid belt, so it is 10 trillion times closer to Hubble than the background galaxy. Image credits: NASA / ESA / Hubble / Pablo García Martín, UAM / Joseph DePasquale, STScI / Alex Filippenko, University of California, Berkeley.

More than 4 billion years ago, the eight major planets around the sun formed by sweeping up debris from the vast disk of dust and gas surrounding the sun.

This is common in the birth process of planets, and the NASA/ESA Hubble Space Telescope has for the first time optically observed a similar disk surrounding a newborn star, providing a glimpse into the solar system's formative years.

Four billion years later, debris still litters the planet's construction yards.

Most of this ancient space debris, or asteroids, lies between the orbits of Mars and Jupiter within the main asteroid belt.

“We are starting to learn more about the presence of a small number of main-belt asteroids,” said Dr. Pablo García Martín, an astronomer at the Autonomous University of Madrid.

“We were surprised to see so many candidate objects.”

“We've had some hints that this population exists, but we're now confirming it with a random asteroid population sample obtained using the entire Hubble archive.”

“This is important for gaining insight into models of the evolution of the solar system.”

Since Hubble orbits around the Earth at high speed, Hubble exposure allows us to follow its trail and capture a wandering asteroid.

When viewed from a telescope on Earth, the asteroid leaves streaks across the photo.

The asteroid appears as an unmistakable curved trajectory in the photo, making the Hubble exposure a “photobomb.”

Hubble observes the asteroid from different perspectives as it moves around Earth, but the asteroid also moves along its own orbit.

By knowing Hubble's position during observations and measuring the curvature of its stripes, scientists can determine the distance to the asteroid and estimate the shape of its orbit.

Most of the asteroids involved are in the main belt between the orbits of Mars and Jupiter.

Their brightness is measured by Hubble's sensitive camera. Then, by comparing its brightness and distance, we can estimate its size.

The faintest asteroid found in the survey is approximately 40 million times less bright than the faintest star visible to the human eye.

“Because the asteroid's position changes over time, you can't find the asteroid's location just by entering the coordinates, because the asteroid may not be there at a different time,” Melin said.

“As astronomers, we don't have time to study images of every asteroid.”

“So we came up with the idea of ​​collaborating with more than 10,000 citizen science volunteers to browse the massive Hubble archive.”

of result appear in the diary astronomy and astrophysics.

_____

Pablo Garcia-Martin other. 2024. Hubble Asteroid Hunter III. Physical properties of newly discovered asteroids. A&A 683, A122; doi: 10.1051/0004-6361/202346771

Source: www.sci.news

Paris is buzzing with excitement as a quirky camel parade sweeps through the city this weekend.

Camels are not your typical finicky herd animals anymore. They are gaining popularity in the world of agriculture.

While the idea of incorporating camel milk into your diet may seem odd to some in Europe or the United States, it has been a dietary staple for many communities for years. Now, camel products are making their way to shelves worldwide.

Currently, it is the United Nations’ international year of the camel, celebrating camels, alpacas, and llamas. Events like the big camel parade in Paris aim to raise awareness about these animals.

Camels already contribute 8% of sub-Saharan Africa’s milk production and are expected to see a significant increase in global trade, reaching $13 billion by the end of the decade.

Experts like Dr. Ariel Ahern from the University of Oxford point out the rapid growth in camel farming, especially in regions like Saudi Arabia, the UAE, Kazakhstan, and Mongolia. They predict that by 2050, camel products may become more common even in western countries like the UK.

Camels are gaining popularity due to their ability to thrive in harsh environments, making them a sustainable alternative in the face of climate change. Their high efficiency in converting food and water into meat and dairy products makes them a valuable resource in regions facing food and water scarcity.

With the potential environmental benefits of camel farming, such as reduced greenhouse gas emissions compared to traditional livestock farming, the shift towards camels in agriculture seems promising.

Why are we seeing a shift towards camels?

The International Year of the Camel aims to raise awareness about the importance of camels in the future food chain. As climate change threatens traditional food sources, camels offer advantages in adapting to dry climates and maximizing resource efficiency.

A group of camels feeding in the desert, shot from directly above, Dubai, United Arab Emirates – Image credit: Getty

Camels’ resilience to extreme conditions, lower resource requirements, and lower environmental impact make them a promising option for sustainable agriculture.

Is it time to add camel to your diet?

Camel products like milk and meat offer nutritional benefits and can be suitable alternatives for those with dietary restrictions. Camel milk, in particular, is rich in vitamin C and iron, making it a healthy option for many.

Studies show that camel milk can help lower blood sugar levels and boost immunity, while camel meat is leaner and higher in iron compared to traditional meats like beef or lamb.

Camel: Coming to a farm near you?

While camel farming is on the rise, experts caution against industrialized models and advocate for more sustainable practices. Free-range, nomadic farming models that allow camels to graze naturally may offer a greener alternative to traditional agriculture.

By utilizing the unique traits of camels, such as their ability to thrive in arid environments and their resource efficiency, we can create a more sustainable and resilient food system for the future.

About our experts

Ariel Ahearn is a lecturer at the University of Oxford, specializing in human geography and rural development. Dr. Ahearn has extensive experience working with nomadic communities in Mongolia and advocating for sustainable land use practices.

Ilse Köhler Rollefson is a German scientist known for her work with camel herders in India and her advocacy for pastoralism and sustainable farming. She is a co-founder of Camel Charisma, promoting eco-friendly camel products.

For more information on camel farming and its potential impact on agriculture, read on.

Source: www.sciencefocus.com

Researchers make breakthrough in understanding animal consciousness

bee Rolling a wooden ball – obviously for fun. The beautiful wrasse fish is Recognize yourself in an underwater mirror. The octopus seems to be like that. reacts to anesthetics And you will avoid environments where you are likely to have experienced pain in the past.

All three discoveries were made in the past five years, and the more scientists experiment with animals, the more they discover that many species have an inner life and may be sentient. It shows that. A surprising range of organisms show evidence of conscious thought and experience, including insects, fish, and some crustaceans.

That’s why a group of top animal cognition researchers has released a new statement they hope will change the way scientists and society view and care for animals.

Nearly 40 researchers signed the petition. New York Declaration on Animal Consciousness” was first presented Friday morning at a conference at New York University. This comes at a pivotal moment, as a plethora of research on animal cognition collides with debates about how different species should be treated.

The declaration says there is “strong scientific support” that birds and mammals have conscious experience, and that there is a “realistic possibility” that consciousness exists in all vertebrates, including reptiles, amphibians, and fish. It has said. The possibility extends to many organisms without backbones, including insects, decapod crustaceans (including crabs and lobsters), and cephalopod molluscs such as squid, octopuses, and cuttlefish, he added.

“If an animal has a real possibility of conscious experience, it would be irresponsible to ignore that possibility in decisions affecting that animal,” the declaration reads. “We should consider welfare risks and use evidence to inform our responses to these risks.”

Jonathan Birch, professor of philosophy at the London School of Economics and principal investigator of the Fundamentals of Animal Senses project, is also one of the signatories of the declaration. He said many scientists had previously thought questions about animal consciousness were unanswerable, but the declaration shows his field is moving in a new direction.

“This has been a very exciting decade for the study of animal minds,” Professor Birch said. “People are boldly going out there in ways that have never been done before, and are excited about the possibility that animals like bees, octopuses, and squids are somehow having conscious experiences.”

From “automaton” to perceiver

There is no standard definition for animal perception or consciousness, but these terms generally refer to the ability to have subjective experiences, i.e. the ability to feel and map the outside world, and to feel emotions such as pleasure and pain. Refers to ability. In some cases, it may mean that the animal has some degree of self-awareness.

In this sense, the new declaration goes against long-standing orthodoxy in historical science. In the 17th century, French philosopher René Descartes argued that animals are nothing more than “material automatons” without souls or consciousness.

Rajesh Reddy, assistant professor and director of the animal law program at Lewis & Clark College, said Descartes believed that animals “cannot feel or suffer.” “There was something stupid and anthropomorphic about feeling sorry for them or empathizing with them.”

In the early 20th century, prominent behavioral psychologists promoted the idea that science should study only observable behavior in animals. rather than emotions or subjective experience.. But in the 1960s, scientists began to reconsider. Research began to focus on animal cognition, primarily other primates.

Birch said the new declaration attempts to “embody an emerging consensus that rejects the 100-year-old view that there is no way to study these issues scientifically.”

Indeed, there has been a recent surge in new discoveries that support the new declaration. As scientists develop new cognitive tests and test existing tests on a wider range of species, there are some surprises.

For example, consider the mirror mark test that scientists sometimes use to see if animals recognize themselves.

In a series of studies, The cleaner wrasse fish seems to have passed the test.

The fish were placed in an aquarium covered with mirrors, but no abnormal reactions were observed. However, when the cover was removed, seven out of 10 fish launched an attack toward the mirror, indicating that they may have interpreted the image as a rival fish.

After a few days, the fish calmed down and attempted strange behaviors never seen before in this species, such as swimming upside down in front of a mirror. Afterwards, some spent an unusual amount of time in front of the mirror observing their bodies. The researchers then placed brown spots under the fish’s skin to resemble parasites. Some fish tried to scrape off the mark.

“They’re able to see wrasse perform a series of steps that you can only imagine seeing in incredibly intelligent animals like chimpanzees and dolphins,” Birch said. “No one in a million years would have expected a small fish to pass this test.”

In other studies, researchers found that: Zebrafish showed signs of curiosity When a new object is introduced into the aquarium and it The squid remembered what it saw and smelled..An experiment caused stress Give electric shock to crayfish, and administered an anti-anxiety drug that is also used in humans. The drug seems to have restored normal behavior.

Birch said these experiments are part of a growing body of animal consciousness research over the past 10 to 15 years. “You have a much broader canvas to study a much wider range of animals, not just mammals and birds, but also invertebrates like octopuses and squid,” he said. “And people are talking about this idea more and more in relation to insects.”

Reddy said researchers may soon need to completely reorient their research, as more and more species are showing these signs.

A new legal perspective

Reddy said the change in scientists’ understanding of animal sentience could have implications for U.S. law, which does not classify animals as sentient at the federal level. Instead, animal-related laws primarily focus on conservation, agriculture, or the treatment of animals by zoos, laboratories, and pet retailers.

“The law moves very slowly and follows society’s views on many of these issues,” Reddy said. “This declaration, and other measures to remind the public that animals are more than just biological automatons, could greatly increase support for increased protections.”

Helge Karl/Getty Images/iStockphoto

State laws vary widely. Ten years ago, Oregon passed a law recognizing that animals are sentient and capable of feeling pain, stress and fear, forming the basis of progressive judicial opinion in the state, Reddy said. he said.

meanwhile, Washington and California These are among the states where lawmakers this year are considering bans on farming octopuses, a species in which scientists have found strong evidence of sentience.

British law has recently changed to consider octopuses as living organisms, just like crabs and lobsters.

“Once you realize that animals are intelligent, the concept of humane slaughter starts to become important. You have to make sure that the methods you’re using on the animals are humane,” Birch said. says. “For crabs and lobsters, very inhumane methods such as dropping them into a pot of boiling water are very common.”

Source: www.nbcnews.com

More Energy Recovery Potential in Wind Turbines Modeled After Condor Wings

The curved tip of a wind turbine blade, or winglet, based on the shape of a condor wing

Kashayar Ranamai Vahanbali

A design change inspired by the wings of the Andean condor could increase the energy produced by wind turbines.

Different types of birds have upturned tips at the ends of their wings, which help maximize lift. Similar features, known as winglets, are commonly used on aircraft wings, but have not been tested on the giant turbine blades used to generate electricity.

Kashayar Ranamai Vahanbali Researchers at the University of Alberta in Canada say collecting experimental data on wind turbines with winglets is extremely difficult due to their size.

His team designed a winglet based on the Andean condor, the heaviest flying bird in the world. The Andean condor can travel vast distances, despite weighing up to 15 kg.

Computer simulations of airflow through the turbine showed that these winglets reduced drag and increased efficiency by an average of 10%.

“Another perspective is that the winglets allow the turbine to capture more wind energy with minimal losses. [resistance]” says Ranamayvahanbury.

Winglets can be retrofitted after a turbine is manufactured, he said, by slipping “sock-like” pieces onto the ends of the blades. Researchers are developing an experimental setup to test models of wind turbine winglets.

Peter Majewski, who recently retired from the University of South Australia, said the research results made sense from an engineering and aerodynamics perspective, but retrofitting existing wind turbines would be prohibitive in terms of downtime and cost. He said it might be realistic.

But for new turbine blades, adding winglets during the manufacturing process can lead to significant performance improvements, he says.

topic:

  • aerodynamics/
  • Renewable energy

Source: www.newscientist.com

Unveiling the creative process behind Monument Valley 2’s heartwarming music: Creating the sound of a warm hug

'TThe part where the mother and child get separated on the Red Mountain is a level fairly early in the game where you have to go back and find the mother. I was completing the sound design and music in the hospital. She was right next to my mother as she slept while she was recovering from open heart surgery. ”

Todd Baker pauses for a moment. He recalls the development process for Monument Valley 2, a 2017 indie puzzle game. Biggest success stories It will remain in the history of mobile games. The second game is more experimental than the first. The number of stories has increased and the atmosphere has changed. While the first title was all optical illusions and impossible objects, the sequel moves away from his MC Escher-inspired towers and spiers to non-Euclidean geometry and brutalism.

At the center of it all are a mother and daughter, wordlessly walking back and forth in each other's paths, desperately trying to stay together as the world heaves and undulates and does its best to tear them apart. It's about women's heritage and relationships, and for Todd there were parallels between fiction and reality. “The fact that this game is about a mother and a child, and the fact that I lost my mother at the end of the year when I was making this game, is very heartbreaking.”

“I wanted the music to speak and tell the story”…Monument Valley 2. Photo: ustwo

Monument Valley 2's soundtrack is the kind of music you want to listen to when you're not playing. Even when separated from the parent game, it's still very enveloping, very rich and textured, and provides a comfortable background for whatever you're doing. Waves of warm, organic tones and ambient, soothing sounds wash over you. This was always Baker's intention. Even before the unfortunate coincidence of fictional and real losses, Monument Valley 2's soundtrack was designed to be soothing, familiar, and gorgeous.

“Basically, what I was trying to do was create the sound of a really warm hug,” Baker said with a laugh, referring to one of the early stages of the game, when the child first comes to his mother. He described the moment he was held in his mother's arms. “At that moment, the kid comes in and I hug him, and there’s a lot of bass going on…I needed a really warm, fuzzy feeling, like this is where I want to be right now. .”

This moment in the game is very important. It's all about setting what's at stake. Yes, this story is abstract and minimalistic, but this moment has such power. Baker creates an impromptu acoustic guitar melody that he layered on three tracks and played on an EBow for a slightly supernatural sound, all backed up by an intoxicating supporting bass note, but it's not unlike the visuals here. I am doing a very important job. Establish everything that's at risk, Apple/iOS friendly, “bright on white”. If you don't watch the game to the end, you'll never see these two reunite.

That resonated with the audience, Baker said. “What's amazing is that now I get messages from people saying, 'This was the soundtrack of my childhood,'” Baker laughs. “They talked to me as adults now who were playing this game when they were 11 or 12 years old and said this is nostalgic and it's a safe space for them. It touches people's hearts. , they have a lot of nostalgia for it now.”

'It touched people's hearts'…Todd Baker performs music from Monument Valley 2 at London's V&A. Photo: ustwo

Baker was responsible for not only the music for Monument Valley 2, but also the entire sound design. Things like how a chime sounds when you swipe or tap on certain interactive elements, or how a little music plays as you explore a curious geometric world. It gets sucked in. This was an opportunity for him to emulate the approach Martin Stig Andersen took with Limbo and Inside. Both games had a huge influence on Monument Valley 2's audio, even though they couldn't be more different in tone.

“From the beginning, I was confident that I could do this. We were able to do the whole project holistically, including discussions about whether to license the music or use other artists for the trailer.” But for this one…I had to bring it myself. I wanted the music to speak and tell the story, and I wanted the rest of the development team to be really excited about it.”

As Baker says this, he imitates a hug and brings it around himself, recreating the hug he tried to evoke in the hearts and ears of players in the game's early moments. A decade after the original game was released, Apple still promotes both Monument Valley and the sequel on the App Store, with the latter installed on at least 30 million of his devices. There's no doubt that millions of people heard echoes of that hug and Baker's relationship with his mother. If you've never played this game with the sound on, find your headphones, head over to the App Store, and give it a try. I promise you, it's worth the effort.

The Monument Valley series turns 10 this month, and to celebrate, developer ustwo Commemorative website.

Source: www.theguardian.com

Photos demonstrate the utilization of AI to reinterpret ancient graffiti

Reinterpretation of etching

Matthew Attard and Galeria Michela Rizzo

Maltese artists at the 60th Venice Biennale Matthew Attard Through the prism of AI-driven technology, we address our nation's maritime heritage, along with concepts of faith and progress. His work focuses on images of ships graffitied by sailors on the stone facades of Maltese chapels from the 16th century to his 19th century, one of his is pictured below.

Boat graffiti in the Chapel of the Visitation of Our Lady in Weed Kilda, Malta

Elise Tonna

Attard, pictured below, used his line of sight to follow notches in the ship's hull, rigging, and billowing sails, a process facilitated by line-of-sight trackers and generative algorithms. “This line of sight was converted by technology into data points, which were further interpreted to produce lines and drawings,” he says.

A database of digital images generated from the data points captured the sculpture from different perspectives, from which works of art such as 3D scans and video works were created.

Matthew Attard wearing an eye tracking device.

Elise Tonna

Marine graffiti resonates with cultures where the relationship with the sea has been and continues to be important, and ships remain a metaphor for hope and survival. Similarly, the Maltese chapels have long been sanctuaries. Attard said he wanted to explore “parallels to the current 'blind faith' in digital technology.”

A reinterpretation of his etching is the impression of a ghostly skeleton, as shown in the main image. “Some would argue that even the most traditional mediums, such as pencil or charcoal, can be considered a form of drawing technique,” he points out. His exhibition, commissioned by the Malta Arts Council, will run at the Malta Pavilion at the Venice Biennale in Italy until 24 November.

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Source: www.newscientist.com

Press the button: The Fallout series is a true gamer’s creation in both appearance and gameplay | Games

I I've been watching the last few episodes of the Fallout series on Prime Video. It's funny and gory, sometimes sentimental, and sometimes silly. In other words, it's exactly the kind of game that oscillates between quiet, tragic moments in which you explore traces of America and scenes in which you run out of ammunition and are chased down a hill by an irradiated scorpion.

Fallout's ensemble cast – highlighted by Walton Goggins' near-immortal ghoul and Ella Purnell's wide-eyed vault-dweller – deftly compartmentalize the different facets of the game's personality. As director Jonathan Nolan pointed out in an interview last week with Bethesda's Todd Howard, game director, this is a common device in television storytelling, but rare in games. Grand Theft Auto V does it well. Each of the three main characters represents a different part of his DNA in GTA (Trevor of violent chaos, Michael of authoritative crime drama, and Franklin of Compton realism).But in most games we play One Or we shape the character so that it becomes unique to us.

It makes it difficult to adapt the game to the screen. But instead of trying to convey the experience of playing a game, Fallout takes a step back to let the broken yet strangely optimistic world of Fallout take center stage, with each character exploring different aspects of that world. is showing.

“Even if you say you're adapting Fallout 3, whose Fallout 3 are you talking about? Because the way you play that game is very different from the way I play it. Because it could have been different,” Nolan told me. “That's the beauty of this kind of game.” [Bethesda] I'm drawn to the types of games that make the most of the medium and decide who your character will be within that world. Obviously, it doesn't lead directly to the series. ”

I was interested: how did Will Nolan play Fallout 3? “I always play as a Boy Scout first because I think my parents are watching,” he said. “So I'm going to make the smart decision and try again and play as a complete heel. But then I get weird, I get uncomfortable, I end up falling into a morally compromised middle ground.” It's a little pitiful.




Aaron Moten, right, one of the stars of Fallout. Photo: Jojo Wilden/Prime Video

I can relate. chaotic good In most games where it's allowed, I'm willing to cause chaos wherever I go, and happily align myself with characters and factions in power, but I’d never do anything to hurt people. I know it’s a game, but Assumption I want it to be a no-consequences place where I can experiment with morality, but I can’t bring myself to play the villain. This is in contrast to many players I know. They immediately start causing chaos in the game world just to see what happens. The kind of person who shoots horses in Red Dead Redemption.

“Every time I get a game and test it, I immediately think, “What will this game be able to do?” No matter what we do, every time we hand the player a weapon, the first thing they see is I’m going to shoot anyone who does,” Todd Howard said with a laugh. “It could be their mother. They’ll shoot whoever it is. Then they’ll be like, ‘Well, I’ll reload.’ ”

Trying to design a choice-based game based on the random whims of the players must be a nightmare, but Howard and Bethesda have decades of experience with it. When I interviewed him over the years, he talked about how players and systems interact to create new stories, and how games make what they do in-game real and meaningful. He spoke eloquently about the unique mechanism that makes you feel as though you are in the dark. You can’t do that with TV or movies. But as the Fallout show proves, if it’s made by people who really understand it, can We tell unique stories that still capture the essence of the games people love.

Fallout is great because, while this is also true of other successful game-to-movie adaptations in recent years, Appearance Yes, the sets are perfect, and they nail the game’s retro-future, nostalgic aesthetic. That’s because Nolan and screenwriters Geneva Robertson-Dworet and Graham Wagner actually played Fallout, understood it, and felt the power of its storytelling for themselves. Rather than trying to clumsily adapt the game’s story into a TV script, they wrote an amazing game expansion fan fiction on a very high budget. I’m all for this approach. Now that we have a generation of TV producers and filmmakers who grew up with games and truly understand them, I would like to see more of them.

Source: www.theguardian.com

Terrorism watchdog slams WhatsApp for allowing UK users as young as 13

Criticism has been directed at Mark Zuckerberg’s meta by Britain’s terror watchdog for reducing the minimum age for WhatsApp users from 16 to 13. This move is seen as “unprecedented” and is expected to expose more teenagers to extremist content.

Jonathan Hall KC expressed concerns about the increased access to unregulated content, such as terrorism and sexual exploitation, that meta may not be able to monitor.


Jonathan Hall described the decision as “unusual”.

According to Mr. Hall, the use of end-to-end encryption by WhatsApp has made it difficult for meta to remove harmful content, contributing to the exposure of younger users to unregulated materials.

He highlighted the vulnerability of children to terrorist content, especially following a spike in arrests among minors. This exposure may lead vulnerable children to adopt extremist ideologies.

WhatsApp implemented the age adjustment in the UK and EU in February, aligning with global standards and implementing additional safeguards.

Despite the platform’s intentions, child safety advocates criticized the move, citing a growing need for tech companies to prioritize child protection.

The debate over end-to-end encryption and illegal content on messaging platforms has sparked discussions on online safety regulations, with authorities like Ofcom exploring ways to address these challenges.

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The government has clarified that any intervention by Ofcom regarding content scanning must meet privacy and accuracy standards and be technically feasible.

In a related development, Meta announced plans to introduce end-to-end encryption to Messenger and is expected to extend this feature to Instagram.

Source: www.theguardian.com

Study reveals 25% of UK toddlers aged three and four have their own smartphone

In the UK, a quarter of three and four-year-olds now own a smartphone, and even children under 13 have smartphones, according to new data. As ministers consider banning mobile phone ownership for children under 16, half of children are already using social media.

Reports from the communications regulator Ofcom show a significant increase in online activity among toddlers to school-age children, with social media usage among 5 to 7-year-olds rising from 30% to 38% in the past year. Furthermore, 76% of children in this age group are using tablets.

These findings support the arguments of those close to Rishi Sunak, urging him to regulate young children’s phone and social media usage. Discussions on potential measures are expected to begin in the coming weeks, with proposals including banning the sale of mobile phones to under-16s, enhancing parental control capabilities, and raising the minimum age for social media platforms to 16.

It is concerning that despite the age requirement of 13 for social media apps, half of children aged 3 to 12 are using at least one social media platform. Michelle Donnellan, the Tech Secretary, emphasized the importance of implementing online safety laws to protect children.

The figures underscore the negative impact of widespread social media use on children’s mental health, with a significant increase in depression and anxiety among adolescents. Experts like Jonathan Haidt recommend delaying smartphone ownership until the age of 16 to address these issues.

Tech Secretary Michelle Donnellan said the figures showed why the Government’s online safety laws were essential. Photo: Andy Lane/EPA

Child safety advocates urge action to enforce age restrictions on social media platforms. Organizations like the Molly Rose Foundation and NSPCC emphasize the need for stronger regulations to protect children online.

New data from Ofcom also reveals an increase in messaging and calling among 5 to 7-year-olds, with more children using apps like WhatsApp and TikTok. The vast majority of children aged 3 to 17 are now online, with younger children favoring tablets and older children owning smartphones.

The smartphone ownership statistics are based on a survey of 2,480 parents with children aged 3 to 17. Ofcom defines smartphones as devices that enable app download, web browsing, and online activity.

Source: www.theguardian.com

Bitcoin Halving: An Explanation of its Impact on Price

Satoshi Nakamoto, the anonymous creator of Bitcoin, still wields influence over the cryptocurrency almost 14 years after vanishing.

This week, a protocol crafted by Nakamoto (an individual or group that went silent in December 2010) will trigger the “Bitcoin halving,” which has historically been tied to price increases. The upcoming halving is set to occur this Saturday.

Here’s a breakdown of what the Bitcoin halving entails and its potential ramifications.

What is Bitcoin halving?

It revolves around how Bitcoins are recorded and generated. Cryptocurrency transactions are recorded on a public ledger called the blockchain. These transactions are grouped into blocks by “miners,” solved, and linked. Miners use specialized hardware to solve cryptographic puzzles and, crucially, receive rewards in newly minted Bitcoins.

Nakamoto’s goal was to cap the total number of Bitcoins at 21 million, so the protocol adjusts to limit the influx of new coins into the market. This is accomplished by halving miners’ rewards every 210,000 blocks, approximately every four years.

The imminent halving is slated to take place early Saturday in the US and UK, reducing the reward for adding a new block to the blockchain from 6.25 Bitcoins to 3.125 Bitcoins. Bitcoin, currently with over 19 million coins in circulation, will continue halving until an estimated 21 million by 2140.

What impact will it have on the price of Bitcoin?

A halving leads to a decrease in the supply of new Bitcoin, potentially raising its price. It’s an economic principle that a decrease in supply with stable demand should drive up the price of an asset.

Data from 10x Research shows that the average prices following the past three halvings (2020, 2016, 2012) increased by 16% in the subsequent 60 days. The 2016 halving initially saw a 6% dip but then rebounded strongly in 2017.

Experts suggest that halvings usually lead to rising prices due to reduced supply, with a peak typically occurring around 500 days post-halving. However, markets have already factored in the halving, and significant price hikes aren’t expected immediately after.

Are there any negative effects?

Bitcoin mining companies, which bear energy and equipment costs to validate transactions, may face financial strain as rewards shrink.

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Andrew O’Neill, managing director of digital assets research at S&P Global, notes that halving the block rewards can impact miners’ profitability significantly, leading to potential closures of unprofitable businesses.

For Bitcoin mining to be economically sustainable, broader adoption across the global economy is required to boost miners’ earnings from transaction fees. However, concerns are rising about the environmental unsustainability of energy-intensive Bitcoin mining.

Critics fear that amateur investors may be drawn into price spikes and hype surrounding the halving, adding another layer of negative impact.

Source: www.theguardian.com

Adopting a low FODMAP diet may be more effective than medication in reducing symptoms of irritable bowel syndrome

Eating less of some types of foods and more of others may ease irritable bowel syndrome

Aamrya/Getty Images

Two types of diets are more effective at treating irritable bowel syndrome (IBS) than drugs, a trial has found.

One diet was designed to be low in FODMAPs, a group of carbohydrates similar to sugars found in dairy products, wheat, and certain fruits and vegetables. The second, less common approach used for IBS is an adaptation of a low-carbohydrate diet that is high in fiber and low in other types of carbohydrates, such as sugar and starch.

In a randomized trial, both diets showed better symptom improvement than standard drug treatment after four weeks.

IBS can cause mysterious symptoms such as diarrhea, constipation, bloating, and abdominal pain that increase or decrease over time. The underlying cause of this condition is unknown.

The usual advice is to avoid common triggers such as caffeine, alcohol and spicy foods. Symptomatic treatments such as laxatives for constipation and drug therapy for diarrhea may be given.

If these measures don’t work, you may want to consider cutting back on foods high in FODMAPs. FODMAPs tend not to be digested until they reach the colon, which is why they are thought to cause bloating and diarrhea. This encourages the colon to retain water, and when the molecules are consumed by bacteria, gas is produced and causes bloating.

Sanna Niebacka Researchers from the University of Gothenburg in Sweden wanted to find out how a regular low-FODMAP diet compared to an alternative approach: high in fiber but low in carbohydrates. In practice, this means eating high-fat, high-protein foods such as meat and dairy products, and sources of fiber include nuts, seeds, beans, and vegetables such as cabbage.

The research team asked around 300 people with IBS to use one of three approaches depending on their symptoms: take medication or adopt one of two diets. The diet provided people with free grocery delivery, as well as detailed meal plans and recipes.

After one month, 76% of the low-FODMAP group reported a significant reduction in symptoms, compared with 71% of the low-carbohydrate diet group and 58% of the drug treatment group.

The big surprise was that a low-carbohydrate, high-fiber diet that didn’t exclude FODMAP-containing foods was about as effective as a low-FODMAP approach, Nybacka says. “We can’t answer any questions as to why. It appears that altering carbohydrate content and reducing FODMAP intake may be beneficial.”

but hazel everitt Researchers at the University of Southampton in the UK say the trial would have been more informative if it had lasted longer. “The problem with many of the IBS diets that have been proposed is that they are very difficult to stick to long-term,” she says.

Participants were followed for up to six months, but during the last five months participants who were initially offered drug treatment were also given dietary advice.

Niebacka says one potential problem with the low-carbohydrate, high-fiber diet is that this group of people had slightly elevated blood cholesterol levels. Therefore, you should seek your doctor’s advice before adopting this diet, she says.

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Source: www.newscientist.com

The mysteries of the Moon may remain unsolved as new lunar missions approach

There is a new space race underway, with missions to the moon increasing at a significant pace. Recently, a spacecraft built by Intuitive Machines became the first U.S. mission to land on the moon since 1972’s Apollo mission.

China is preparing to launch Chang’e 6, furthering their lunar exploration program with plans to bring back lunar rocks from the far side of the moon. A NASA study suggests that 22 international missions could reach the moon by the end of 2026, potentially leading to astronauts leaving footprints on the moon once again.

Despite the exciting progress, researchers like Dr. Alanna Krolikowski and martin elvis warn of dangers overlooked in the rush of exploration. They emphasize the need to protect Sites of Extremely Scientific Significance (SESI) on the moon, similar to protecting special sites on Earth.


Krolikowski stresses the urgency of implementing SESI protections to avoid irreversible harm to these important areas. Two key locations on the moon, its backside shielded from Earth’s radio noise and its poles with valuable volatiles like water ice, require preservation for scientific research and exploration.

“The problem is urgent,” says Krolikowski. “We are facing a rapidly closing window in which SESI protections can be implemented to avoid the worst possible irreversible harm.”

Special attention is drawn to the moon’s poles with areas of eternal darkness that trap important volatiles. These regions hold valuable information about the history of the solar system, particularly in studying the early universe.

Researchers advocate for careful management of activities on the moon to avoid contaminating these special areas and preserving their natural state for exploration.

Proposals for protecting lunar SESIs include identifying and characterizing these areas, establishing rules in national and international space policies, and initiating negotiations under the United Nations for effective international cooperation.

Despite the challenges, experts like Krolikowski, Elvis, and Crawford stress the importance of getting it right to preserve the moon’s unique habitats and secrets. With increasing lunar activities, taking action now is crucial.


About our experts

Dr. Alanna Krolikowski is an assistant professor of political science at the Missouri Institute of Technology, specializing in space policy research published in academic journals like space policy and global policy.

martin elvis is an astronomer at the Harvard-Smithsonian Center for Astrophysics focusing on space economics, law, and ethics, with research published in Nature and other journals.

Professor Ian Crawford is a planetary scientist at Birkbeck University, known for his lunar science and exploration research published in various scientific journals.

Source: www.sciencefocus.com

Cocaine seems to exploit brain pathways that prioritize food and water.

Diagram of the human brain reward pathway

Fernando da Cunha/Science Photo Library

Continued use of drugs such as cocaine and morphine is thought to affect the way the brain prioritizes the body’s basic needs, but we are only now understanding how this happens.

When people repeatedly misuse drugs, they can experience long-term behavioral changes, where they choose to take drugs instead of doing what they need to do, such as eating or drinking.

A brain pathway called the mesolimbic reward system is thought to be involved in this process, but few studies have directly compared the system’s response to drug intake and its response when its innate needs are not met.

now, bowen tan from Rockefeller University in New York and colleagues showed that the same neurons are activated in these two situations. They revealed this using sophisticated microscopy equipment that can track the activity of individual neurons in the brains of mice in a state of withdrawal after repeated exposure to these drugs.

“There has long been a debate in this field about whether there are specialized cell types that encode only drug value and specialized cell types that encode only natural reward value,” Tan said. To tell. “What we saw is that these drugs of abuse typically activate the same set of neurons as natural rewards.”

The researchers also observed that after giving mice cocaine or morphine, their food and water intake decreased, while the neural responses needed to satisfy basic needs were disrupted.

“What’s really remarkable about this finding is that the strong neural responses to food and water are almost replaced by responses to drugs,” he says. Jeremy Day At the University of Alabama at Birmingham. “[This suggests] Drug rewards can override the way the brain converts desire states into behaviors that satisfy those desires.”

Tan and his team also identified a gene called.Rev which appears to be necessary for the drug to have this effect. Rev Because it is part of a cell signaling pathway that is also found in humans, future research could explore how inhibiting this pathway could be used as a treatment for substance misuse, he said. To tell.

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Source: www.newscientist.com

Study finds that competition between species was a significant factor in the growth and fall of human populations

Traditionally, climate has been thought to be the cause of the emergence and extinction of human species. However, interspecific competition is known to play an important role in most vertebrates. A new study shows for the first time that competition has been the basis of speciation (the rate at which new species emerge) over five million years of human evolution.It also means that our speciation patterns homo The pedigree was different from most others.

a homo heidelbergensis, Neanderthals and Cro-Magnons. Image credit: SINC / Jose Antonio Peñas.

“We have ignored how competition between species has shaped our own evolutionary tree,” says Dr Laura van Holstein, an anthropologist at the University of Cambridge.

“The effects of climate on the human species are only part of the story.”

“In other vertebrates, species form to fill ecological niches. Darwin's finches, for example, have evolved large beaks for cracking nuts, while others have evolved large beaks for eating certain insects. Some have evolved small beaks to accommodate them. Once their respective resource niches are filled, competition ensues, no new finches emerge, and extinction takes over.”

Dr Van Holstein and Professor Robert Foley from the University of Cambridge used Bayesian modeling and phylogenetic analysis to show that, like other vertebrates, most species of humans formed when competition for resources and space was low. It was shown that

“The pattern seen in many early humans is similar to all other mammals,” van Holstein says.

“The speciation rate increases, then levels off, at which point the extinction rate begins to increase. This suggests that competition between species was a major evolutionary factor.”

However, when the authors analyzed our group, homothe findings were “bizarre.”

for homo The pattern of evolution of the lineage leading to modern humans suggests that interspecific competition actually led to the emergence of even newer species, a complete departure from trends seen in almost all other vertebrates. It's a reversal.

“The more types there are, the more homo The more there are, the higher the rate of speciation,” Dr. van Holstein said.

“So once those niches were filled, something caused more species to emerge. This is almost unprecedented in evolutionary science.”

The closest comparison she found was a species of beetle that lives on the island. On islands, confined ecosystems can produce unusual evolutionary trends.

“The evolutionary patterns we see across species are homo “The direct link to modern humans is more closely related to island beetles than to other primates or other mammals,” Dr van Holstein said.

www.sci.news

Paleontologists Discover New Species of Massive Triassic Ichthyosaur

Ichthyotitan severnensis It lived in the Triassic seas around 202 million years ago and may have grown over 25 meters (82 feet) long.



Ichthyotitan severnensis. Image credit: Gabriel Uguet.

Ichthyosaurs are dolphin-like marine reptiles known from hundreds of fossils from the time of the dinosaurs.

These creatures ranged in size from less than a meter to over 20 meters (65 feet) in length.

All animals gave birth to live young in the sea, and some had giant eyes and so-called warm-blooded physiology, and some were fast swimmers and deep divers.

“Ichthyosaurs first evolved during the early Triassic period, about 250 million years ago,” said Dr Dean Lomax and colleagues from the Universities of Bristol and Manchester.

“Within a few million years, some ichthyosaurs evolved to reach lengths of 15 meters or more, and by the late Triassic period (about 200 million years ago), the largest fish, including the newly described ichthyosaurs. The dragon has evolved. Ichthyotitan severnensis

“But this reign didn’t necessarily last long. Some species of ichthyosaurs continued to roam the oceans for millions of years, but these ‘giant ichthyosaurs’ It is thought to have become extinct during the Tatami-Jurassic extinction event. And this unique group of marine reptiles never reached such a world again. Huge size.”

two fragmentary jaw bones Ichthyotitan severnensis Collected from the uppermost layer of the Triassic period Westbury Mudstone Formation Located in Somerset, England.

Based on the length of the fossil, the new species could have been a whopping 25 meters long, or twice as long as a city bus.

“In 2018, my team studied and described a giant jawbone, and we were hopeful that one day another jawbone would be revealed,” Dr. Lomax said.

“The new specimen is more complete and better preserved, showing that there are two large bones (called quadrilateral bones) with unique shapes and structures.”

“It’s quite amazing to think that gigantic ichthyosaurs, the size of blue whales, were swimming in the seas around Britain during the Triassic period.”

“These jaw bones provide intriguing evidence that perhaps someday the complete skull or skeleton of these giants may be discovered. You never know.”

discovery of Ichthyotitan severnensis is explained in paper in diary PLoS ONE.

_____

DR Lomax other. 2024. The last giant: new evidence of a giant Late Triassic (Rhaetian) ichthyosaur from Britain. PLoS ONE 19 (4): e0300289; doi: 10.1371/journal.pone.0300289

Source: www.sci.news

Obesity directly correlated with increased risk of breast cancer, say researchers

Reading time: 7 minutes


Breast cancer affects thousands of people each year. Scientists have shown that many factors can influence breast cancer, including age, physical inactivity, and obesity. However, it is unclear exactly how obesity and breast cancer are related.

Previous researchers have shown that tissue inflammation in obese patients is related to cancer. Other researchers have shown that obese patients have the following characteristics: specific genetic mutations It is also related to cancer. However, how this mutation acts to generate different types of tumors is not fully understood.

Ha-Linh Nguyen and colleagues recently investigated the relationship between breast cancer and obesity. Nguyen and his team wanted to determine how obesity affects breast cancer by examining the tissue cell and genetic profiles of breast cancer in obese patients. Their goal was to see if doctors could develop more targeted treatments for breast cancer based on the genetic mutations involved.

They collected genetic data from the tumors of more than 2,000 breast cancer patients collected during multiple large-scale breast cancer studies conducted by five accredited cancer research institutions. To ensure that no changes had occurred in the breast tumors, the researchers only used data from patients who had not yet started cancer treatment.

The researchers defined obesity based on the patient’s weight-to-height ratio. body mass index, or BMI. They used patients’ BMI data to classify patients into three categories: obese, overweight, and underweight. An obese patient, her BMI was over 30 kilograms per square meter (kg/m2).2), the BMI of overweight patients was 25–30 kg/m2.2lean patients had a BMI of 18.5 to 25 kg/m.2. For reference, the average BMI for adults is approximately 26 kg/m3.2.

Patients were then further categorized based on breast tumor type. These categories include patients with tumors that originate in the milk-producing glands of the breast. Invasive lobular carcinoma tumoror a comparison of patients with ILC tumors and patients without specific tumor types.

The researchers also took into account other biological factors used to identify the type of breast cancer. estrogen receptor. Tumors in patients with estrogen receptor-positive breast cancer contain receptors that use the hormone estrogen to stimulate tumor cell growth. The tumors of breast cancer patients who are estrogen receptor-negative do not contain this receptor.

They also looked at another way to determine the type of tumor, a method called. HER2 factor. HER2-positive breast cancer patients contain a protein called human epidermal growth factor 2, which allows cancer cells to multiply rapidly. The researchers used these biochemical markers to classify patients by tumor type, and then used statistical analysis to distinguish between tumor types in obese patients and those in lean and overweight groups. We compared the types.

Researchers found that in obese patients with non-specific tumors that are estrogen receptor positive and HER2 negative, BMI influences breast cancer in the same way that age influences cancer development. The researchers explained that as we age, the body’s immune response slows down, giving cancer cells more time to accumulate before the body reacts and stops the process. They suggested that these results support the idea that both age and obesity are risk factors for developing breast cancer.

The scientists then looked at whether the tumors in each group had one or more cancer-causing mutations. The research team specifically looked at genes that researchers had previously shown had mutations that cause breast cancer. They also examined tumor DNA to see if there were mutations that caused deletions or amplifications of specific parts of the DNA. Change number of copies.

Researchers found different genetic mutations in patients with different BMIs. They found that a gene involved in cell division signaling, called P1K3CA, was less mutated in obese patients who were estrogen receptor positive, HER2 negative, and had unspecific tumors. Mutations in two other HER genes, CCND1 and CCNE1, were more common in obese patients with estrogen receptor-positive tumors.

The researchers concluded that their study showed a genetic link between breast cancer and obesity. They suggested that some genetic mutations found in tumors of obese patients, particularly CCND1 and CCNE1 mutations, may enable targeted breast cancer treatments. They suggested that future researchers should investigate how the biochemical pathways these genes are associated with actually contribute to breast cancer formation to better develop treatments. .


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original research: Obesity-related changes in the molecular biology of primary breast cancer

research has been published:July 21, 2023

research author: Harinh Nguyen, Tatiana Geukens, Marion Mehtens, Samuel Aparicio, Ayse Bassez, Ake Borg, Jane Block, Anejan Brooks, Carlos Caldas, Fatima Cardoso, Maxim de Schepper, Mauro DeLorenzi. , Caroline A. Drucker, Anuska M. Glass, Andrew R. Green, Edoardo Isnardi, Jörn Eifjords, Hazem Kout, Stian Knapskog, Savitri Krishnamurthy, Sunil R. Lakhani, Anita Langerod, John W. M. Martens, Amy E. McCart-Reid, Lee Murphy, Stefan Nauraz, Selina Nick-Zinal, Ines Nebelsteen, Patrick Neven, Martine Picard, Coralie Ponsetto, Kevin Puni, Colin Purdy, Emad A. Raka, Andrea Richardson, Emile Rutgers, Anne Vincent-Salomon, Peter T. Simpson, Marjanka K. Schmidt, Christos Sotiriou, Paul N. Spann, Kiat. Tee Benita Tan, Alastair Thompson, Stefania Tommasi, Karen van Baeren, Marc van de Wivel, Steven van Leer, Laura van't Veer, Giuseppe Viale, Alan Viali, Hanne Voss, Anke T. Witteveen, Hans Wildyas, Giuseppe Floris, Abhishek D. Garg, Anne Smeets, Dieter Lambrecht, Elia Biganzoli, Francois Richard, Christine Desmet

The research was conducted at the following locations:: Katholieke Universiteit Leuven (Belgium), Lund University (Sweden), Netherlands Cancer Institute (Netherlands), University of Cambridge (UK), Champalimaud Clinical Center/Champalimaud Foundation (Portugal), University of Lausanne (Switzerland), SIB Swiss Institute of Bioinformatics (Switzerland), Antoni van Leeuwenhoek Hospital (Netherlands), University of Nottingham (UK), University of Iceland (Iceland), University Hospitals of Leicester NHS Trust (UK), University of Bergen (Norway), and University of Texas MD Anderson. University of Queensland, Herston (Australia), Royal Brisbane and Women's Hospital, Herston (Australia), Oslo University Hospital, Ullenjausen (Norway), Erasmus University Medical Center, Rotterdam (Netherlands), University of Manitoba , Manitoba Institute for Cancer Treatment (Canada), University Hospital Leuven (Belgium), Jules Bordet Institute and Free University of Bruxelles (Belgium), European Organization for Research and Treatment of Cancer (EORTC) Headquarters (Belgium), University of Dundee (UK) , Nottingham University Hospitals NHS Trust (UK), Johns Hopkins University (USA), Netherlands Cancer Institute (Netherlands), Institut Curie, PSL Research University (France), Radboud University Medical Center (Netherlands), Sengkang General Hospital ( Singapore), National Cancer Center (Singapore), Baylor College of Medicine (USA), IRCCS Istituto Tumouri “Giovanni Paolo II” (Italy), University of Amsterdam (Netherlands), University of Antwerp (Belgium), UCSF Helen Diller Family Institute Cancer Center (USA), European Institute of Oncology IRCCS (Italy), University of Milan (Italy), Synergie Lyon Cancer, Plateforme de Bio-informatique 'Gilles Thomas' (France), Università degli Studi di Milano (Italy)

This research was funded by: Luxembourg Cancer Foundation, European Research Council, University of Leuven.

Availability of raw data: Data from the ICGC cohort includes: ICGC Data Portalthe data from ELBC includes: gene expression omnibus Accession number GSE88770 provides access to data from MINDACT. EORTCindividual patient read count data can be accessed below. bio keythe raw sequence reads include European Genomic Phenomena Archive Research No. EGAS00001004809 and data accession number. EGAD00001006608

Featured image credit: Photo provided National Cancer Institute upon unsplash

This summary was edited by: Aubrey Zirkle

Source: sciworthy.com

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