Your ability to cultivate a stable and consistent sense of self is nothing short of remarkable.
Throughout our lives, we encounter significant transformations, evolving from infants to adults—acquiring new knowledge, forgetting some, forming fresh relationships, and letting go of old ones. These experiences are interspersed with vivid dreams and fleeting moments each night.
Yet, amidst all these changes, we continue to perceive ourselves as the same individuals. This phenomenon can be attributed to the ongoing developmental processes within the brain, which is more adaptable and delicate than you might think.
Classic studies from the late 20th century, such as those involving cases where half of the brain was severed as a radical epilepsy treatment, illustrate this concept.
Interestingly, these cases exhibited strange consequences, like patients performing contradictory movements, such as lifting a button with one hand while undoing it with the other. Nevertheless, they still maintained a coherent sense of self.
These individuals even crafted explanations for their unusual behaviors, demonstrating that their brains were actively working to create a unified personal narrative.
In healthy individuals, psychological studies have revealed memory patterns that bolster this constructed identity.
For instance, we tend to remember and reflect on experiences that align with our self-perception. If you identify as an introvert, you may find it easier to recall and emphasize past memories that resonate with that identity.
Essentially, you are curating your personal autobiography to fit your current self-concept.
The medial prefrontal cortex, located at the front of the brain just behind the forehead, plays a crucial role in regulating this structure.
Research indicates that when people identify traits that best describe themselves—whether in the present or future—this brain region is significantly more active than when they assess similar qualities in others.
Our constructed sense of self also extends to our possessions. During brain scans, the medial prefrontal cortex shows increased activity when individuals view their belongings, while this response diminishes for unfamiliar items.
This illustrates how quickly and adaptively our brains reshape our personal boundaries.
Our sense of self extends to our possessions – Image credit: Robin Boyden
Memory processes are also vital in this ongoing construction of self.
Damage to the hippocampus, located deep within the brain alongside the temples, can prevent individuals from envisioning their past or future—highlighting how reliant our identity is on active brain functions.
Not only does your brain construct a sense of self over time, but it also maintains it spatially, providing a stable sense of ownership over your body.
Another critical region, known as the temporoparietal junction (located behind the ear), significantly influences this aspect of identity.
A study conducted in 2005 demonstrated that electrically stimulating this brain area during surgery could induce out-of-body experiences in patients, making them feel as though they were floating outside themselves.
Thus, while our sense of a stable self often feels entirely convincing, it can be disrupted by brain injuries or even by carefully orchestrated neural experiments.
Overall, the evidence suggests that our experience of “me-ness” is a constructed phenomenon, tirelessly maintained by the brain.
This article answers the question posed by Southampton’s Frank Ross: “How does my brain create a sense of self?”
If you have any inquiries, please reach out via email at:questions@sciencefocus.com or send us a messageFacebook,Twitter or Instagram (remember to include your name and location).
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Meditation and Low Doses of 5-MeO-DMT Induce Similar Effects
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A master meditator dedicated 15 years to mastering ego quieting. Brain scan studies indicate he may have utilized powerful psychedelics to attain an altered state.
“At low doses, there’s a significant overlap in brain activity between this psychedelic and non-dual meditative states,” explains Christopher Timmerman of University College London.
The realm of psychedelic research is expanding rapidly, revealing how substances like 5-MeO-DMT can enhance our understanding of consciousness and improve mental health. This compound, often sourced from North American toads, is particularly compelling due to its ability to rapidly disrupt mental processing without producing vivid visuals like other psychedelics.
Timmerman and his team conducted a detailed comparison between the altered states induced by 5-MeO-DMT and advanced meditation. They collaborated with lamas, experts in the Karma Kagyu tradition of Tibetan Buddhism, amassing over 54,000 hours of meditation data.
During three laboratory sessions, lamas meditated for 30 to 60 uninterrupted minutes, followed by either a placebo or varying doses of 5-MeO-DMT (5 or 12 milligrams). Their brain activity was meticulously measured during each scenario, alongside reports on their thoughts and sense of self post-session.
Findings revealed that low doses of 5-MeO-DMT (5 milligrams) created remarkable similarities in brain patterns to those observed during meditation. Both scenarios exhibited heightened alpha activity, which is often linked to a relaxed state, and a diminished response to external stimuli compared to placebo and baseline conditions. Gamma-ray activity, which relates to cognitive engagement, was also reduced.
Timmerman noted that while both experiences fostered a calm feeling where the lama’s thoughts “came and then vanished,” the meditative state offered a deeper sense of interconnectedness and mental clarity.
In contrast, higher doses (12 milligrams) of 5-MeO-DMT escalated gamma-ray activity, leaving the lama feeling entirely detached from his surroundings and even experiencing an overwhelming bright light. He remarked, “I’m not thinking about anything,” indicating a complete disconnect from awareness of his body and environment.
The higher dosage was linked to increased neuronal firing and entropy, suggesting overwhelming sensory input compared to both placebo and baseline conditions. Conversely, lower doses resulted in decreased neuronal firing and entropy.
Lama Records Brain Activity During Meditation
Christopher Timmerman
Researchers state that these findings are pivotal in connecting neural pathways to the “collapse of the ego” and the sensation of “contentless consciousness.” However, variations in brain activity do not fully capture the lama’s subjective experiences, acknowledges Matthew Sachet from Harvard Medical School.
This study focused on a single seasoned meditator, indicating potential limitations in broader applicability, particularly given the variability in brain activity-related studies. Additionally, ensuring participants are blinded in psychedelic studies poses challenges due to the identifiable side effects of psychedelics; fortunately, lamas reported no such effects.
Nonetheless, Timmerman asserts that if future research confirms safe integration of 5-MeO-DMT enhances the benefits of advanced meditation, it may have significant implications for a wider audience. He is conducting ongoing research to explore if the drug can facilitate faster progress for newbies to meditation but strongly advises against unregulated home use, as 5-MeO-DMT remains illegal in many jurisdictions.
Meanwhile, Sachet suggests that those seeking the mental health advantages attributed to 5-MeO-DMT might find meditation a practical alternative, offering overlapping experiences without the risks of toxicity or addiction.
Meditation and Low Doses of 5-MeO-DMT: Comparable Effects on Spiritual Experiences
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A highly skilled meditator dedicated 15 years to mastering ego quieting techniques. Recent brain scans reveal that he may have achieved a similar state using low doses of psychedelic substances.
According to Christopher Timmerman from University College London, “At low doses, there appears to be significant alignment in brain activity between this psychedelic state and non-dual meditation practices,” a meditative form that transcends the self-world distinction.
The field of psychedelic research is rapidly evolving, as scientists seek to explore how substances like 5-MeO-DMT can enhance consciousness and mental well-being. Notably derived from North American toads, 5-MeO-DMT is under scrutiny due to its unique effects: Rapid disruption of mental processing without vivid hallucinations.
Timmerman and his team undertook a study comparing the psychedelic state induced by 5-MeO-DMT with advanced meditative practices. Collaborating with lamas from the Karma Kagyu school of Tibetan Buddhism, they recorded over 54,000 hours of meditation.
In a controlled setting, the lamas practiced meditation for 30 to 60 minutes, followed by either a placebo or low/high doses of 5-MeO-DMT. Brain activity was measured throughout these conditions, and post-session reflections on thoughts and self-perception were recorded.
They discovered that low doses (5 milligrams) of 5-MeO-DMT produced notable parallels in brain activity to meditative states. Scans indicated increased alpha activity, associated with a relaxed state of wakefulness, and reduced gamma activity linked to cognitive engagement, compared to both placebo and baseline conditions.
Timmerman pointed out that while both scenarios offer a calming effect where the lama’s thoughts “came and then vanished,” meditation provided a deeper sense of interconnectedness and mental clarity.
Higher doses (12 milligrams) of 5-MeO-DMT, however, boosted gamma activity. The lama described feelings of complete detachment from his surroundings, overwhelmed by intense white light. “I’m not thinking about anything,” he recounted, experiencing full disconnection from his body and environment.
This elevated dose also correlated with increased neuronal firing and entropy, indicating more unpredictable firing patterns compared to both placebo and baseline sessions, thus overwhelming his sensory perceptions. Conversely, lower doses resulted in decreased neuronal firing and entropy.
Lama Recording Brain Activity During Meditation
Christopher Timmerman
The research findings suggest a connection between different neural pathways, relating to the “collapse of the ego” and the sensation of “contentless consciousness.” However, changes in the lama’s brain activity do not necessarily account for his subjective experiences, as noted by Matthew Sachet from Harvard Medical School.
It’s essential to note that this study involved only one highly skilled meditator, potentially limiting the broader applicability of results, particularly as brain activity assessments can offer varying reliability. Additionally, blinding participants in psychedelic studies presents challenges due to the typical side effects of these substances, which can alert participants to their experience. Fortunately, no such effects were reported by the lamas.
Nonetheless, Timmerman emphasizes that if further research confirms the safe usage of 5-MeO-DMT can deliver comparable advantages to advanced meditation, the implications could benefit a wider audience. He is currently investigating whether this substance can expedite the learning curve for novice meditators, cautioning against unsupervised use, especially since 5-MeO-DMT remains illegal in several regions.
Meanwhile, Sachet posits that for individuals seeking mental health benefits from 5-MeO-DMT, meditation might provide “a viable path to a state that overlaps, at least partially, with some psychedelic effects,” sans the associated risks of toxicity or addiction.
Examining Resilience to Alzheimer’s Disease: Why Some Individuals Remain Symptom-Free
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Recent studies reveal that some individuals exhibit brain changes tied to Alzheimer’s disease yet show no symptoms like memory loss. Though the reasons remain unclear, innovative research is uncovering protective factors that may prevent cognitive decline.
Alzheimer’s disease is marked by amyloid plaques and tau tangles accumulating in the brain, widely believed to contribute to cognitive decline. However, some individuals, known for their resilience, defy this notion. In 2022, Henne Holstege and her team at the University Medical Center in Amsterdam discovered that certain centenarians retain good cognitive function despite these pathological changes.
Expanding on this research, the team conducted a new study involving 190 deceased individuals. Among them, 88 had Alzheimer’s diagnoses, while 53 showed no signs of the disease at death. Their ages ranged from 50 to 99, and 49 were centenarians with no dementia, though 18 exhibited cognitive impairment previously.
The focus was on the middle temporal gyrus—an early site of amyloid plaques and tau tangles in Alzheimer’s. Interestingly, centenarians with elevated amyloid levels had tau levels akin to those without Alzheimer’s, suggesting that limiting tau accumulation is critical for resilience, according to Holstege.
While amyloid plaques are linked to cognitive decline, Holstege posits that tau accumulation may activate a cascade of symptoms. Notably, amyloid plaques alone may not cause significant tau tangling. “Without amyloid, tau can’t spread,” she explains.
Further analysis of approximately 3,500 brain proteins revealed only five were significantly associated with high amyloid plaques, while nearly 670 correlated with tau tangles. Many of these proteins are involved in crucial metabolic processes like cell growth and waste clearance. Holstege emphasizes, “With amyloid, everything changes; with tau, it’s a different story.”
In the cohort of 18 centenarians with high amyloid levels, 13 showed significant tau spread throughout the middle temporal gyrus, a pattern similar to Alzheimer’s, but the overall tau presence remained low.
This distinction is vital, as diagnosis hinges on tau spread, indicating that accumulation, not just proliferation, triggers cognitive decline. “We must understand that proliferation doesn’t mean abundance,” Holstege clarifies.
In a second study, Katherine Prater and her team at the University of Washington examined 33 deceased individuals—10 diagnosed with Alzheimer’s, 10 showing no signs, and 13 deemed resilient. Most subjects were over 80 and underwent cognitive assessments within a year before death.
In line with previous findings, the research indicated that tau was present but not accumulated in resilient brains. Though the mechanisms remain elusive, Prater theorizes that microglia—immune cells regulating brain inflammation—might play a crucial role in maintaining cognitive function in resilience.
The team also conducted genetic studies on microglia from the dorsolateral prefrontal cortex, essential for managing complex tasks. They discovered that resilient individuals’ microglia exhibited heightened activity in messenger RNA transport genes compared to those with Alzheimer’s. This suggests effective gene transport, vital for protein synthesis, is preserved in resilient brains.
“Disruptions in this process can severely impact cell function,” Dr. Prater remarked at the Neuroscience Society meeting in San Diego. However, its direct relationship to Alzheimer’s resilience remains to be elucidated.
Moreover, resilient microglia demonstrated reduced activity in metabolic energy genes compared to those in Alzheimer’s patients, mirroring patterns in healthy individuals. This suggests heightened energy expenditure in Alzheimer’s due to inflammatory states that disrupt neuronal connections and lead to cell death.
“Both studies indicate that the human brain possesses mechanisms to mitigate tau burdens,” Prater concludes. Insights gained from this research could pave the way for new interventions to delay or even prevent Alzheimer’s disease. “While we aren’t close to a cure, the biology offers hope,” she stated.
Recent MRI studies reveal that yawning is not simply a sign of fatigue or boredom; it reorganizes fluid flow in the brain, indicating that yawning is unique for each individual.
Yawning is observed in most vertebrates, yet its precise purpose remains largely unclear. Theories suggest that yawning enhances oxygen intake, regulates body temperature, boosts fluid circulation in the brain, and modulates cortisol hormone levels.
“Crocodilians yawn, and even dinosaurs likely did too. This behavior has evolutionary significance, but why does it persist today?” queries Adam Martinac from Neuroscience Research Australia, a non-profit medical organization.
To understand yawning’s mechanisms and its impact on the body, Martinac and his team involved 22 healthy participants, evenly divided by gender, in their study.
Participants underwent MRI scans while performing four distinct breathing actions: regular breathing, yawning, voluntarily suppressing yawns, and deep breathing.
The data analysis revealed surprising findings. The initial hypothesis was that yawning and deep breathing would similarly facilitate the movement of cerebrospinal fluid (CSF) out of the brain.
“However, yawning caused CSF to flow in the opposite direction compared to deep breathing,” states Martinac. “We were genuinely surprised by this outcome.”
Specifically, the study discovered a strong directional coupling between CSF and venous blood flow during yawning, both moving away from the brain toward the spine. This stands in contrast to deep breathing, where CSF and venous blood typically travel in opposing directions—CSF flows in while venous blood flows out.
The specific mechanisms governing CSF movement during yawning, including the volume expelled, remain unclear. Current estimates suggest a mere few milliliters of CSF are moved per yawn. Future research aims to quantify this further.
“It’s likely that neck, tongue, and throat muscles collaborate to facilitate this fluid movement,” he adds.
Another noteworthy finding is that yawning augmented carotid artery inflow by over one-third compared to deep breathing. This is presumably because yawning clears CSF and venous blood from the cranial cavity, allowing for increased arterial inflow.
Each participant exhibited a distinct “yawn signature,” showcasing variability even in tongue movements. “It seems that everyone has a unique pattern to their yawns,” says Martinac.
One intriguing area for future research is the physiological benefits arising from CSF movement during yawning.
Theories suggest that this could relate to thermoregulation, waste removal, or potentially other unexplored functions. “It is possible to live without yawning, but there are several subtle effects that likely assist in waste management, temperature control, and even the social dynamics of yawning,” he explains.
The contagious nature of yawning adds another layer of mystery and proved essential for this study, as video footage of yawns was shown to participants while they were inside the MRI scanner.
“In our lab meetings, I always have to speak last because my discussion of this research triggers yawning in everyone else,” Martinac shares.
Researchers like Andrew Gallup from Johns Hopkins University highlight the significant findings of the study, emphasizing its contributions to our understanding of yawning. He also noted that some of the findings have been understated, particularly those affirming yawning’s role in temperature regulation.
“The observed 34% increase in internal carotid artery flow during yawning is a critical finding that deserves more attention,” Gallup asserts.
He further noted that the study focused on contagious yawns versus spontaneous yawns, indicating that spontaneous yawns may induce even greater changes in CSF and blood flow.
“The video suggests contagious yawns are shorter than the average spontaneous yawn, which lasts about six seconds,” he notes.
Professor Yossi Rathner from the University of Melbourne agrees the team may have underestimated certain findings but opposes some claims concerning thermoregulation.
“Increased sleep pressure can elevate levels of a compound called adenosine that accumulates in the brain stem. Yawning seems to facilitate fluid movement in the brain stem, helping to flush out adenosine, temporarily alleviating sleep pressure and boosting alertness,” Rathner explains. “While this isn’t a direct conclusion from the study, the data strongly implies this relationship.”
Revitalizing Brain Organoids: A Breakthrough in Vascular Integration
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A pioneering advancement has been made in growing a miniaturized version of the developing cerebral cortex, crucial for cognitive functions like thinking, memory, and problem-solving, complete with a realistic vascular system. This advancement in brain organoids offers unprecedented insights into brain biology and pathology.
Brain organoids, often referred to as “mini-brains,” are produced by exposing stem cells to specific biochemical signals in a laboratory setting, encouraging them to form self-organizing cellular spheres. Since their inception in 2013, these organoids have significantly contributed to research on conditions such as autism, schizophrenia, and dementia.
However, these organoids have a significant limitation: they typically start to deteriorate after only a few months. This degradation occurs because a full-sized brain has an intricate network of blood vessels that supply essential oxygen and nutrients, while organoids can only absorb these elements from their growth medium, leading to nutrient deprivation for the innermost cells. “This is a critical issue,” remarks Lois Kistemaker from Utrecht University Medical Center in the Netherlands.
To mitigate this issue, Ethan Winkler and researchers at the University of California, San Francisco, devised a method to cultivate human stem cells for two months, resulting in “cortical organoids” that closely resemble the developing cerebral cortex. They then introduced organoids composed of vascular cells, strategically placing them at either end of each cortical organoid, facilitating the formation of a vascular network throughout the mini-brain.
Crucially, imaging studies revealed that the blood vessels in these mini-brains possess hollow centers, or lumens, akin to those found in natural blood vessels. “The establishment of a vascular network featuring lumens similar to authentic blood vessels is impressive,” states Madeline Lancaster, a pioneer in organoid research at the University of Cambridge. “This represents a significant progression.”
Past attempts to incorporate blood vessels within brain organoids have failed to achieve this crucial detail; previous studies typically resulted in unevenly distributed vessels throughout the organoids. In contrast, the blood vessels formed in this new experiment exhibit properties and genetic activities more closely aligned with those in actual developing brains, thereby establishing a more effective “blood-brain barrier.” This barrier protects the brain from harmful pathogens while permitting the passage of nutrients and waste, according to Kistemaker.
The implications of these findings indicate that blood vessels are crucial for delivering nutrient-rich fluids necessary for sustaining organoids. Professor Lancaster emphasizes, “To function properly, blood vessels, similar to the heart, require a mechanism for continuous blood flow, ensuring that deoxygenated blood is replaced with fresh, oxygen-rich blood or a suitable substitute.”
Following a heart attack, the brain processes signals directly from sensory neurons in the heart, indicating a crucial feedback loop that involves not only the brain but also the immune system—both vital for effective recovery.
According to Vineet Augustine from the University of California, San Diego, “The body and brain are interconnected; there is significant communication among organ systems, the nervous system, and the immune system.”
Building on previous research demonstrating that the heart and brain communicate through blood pressure and cardiac sensory neurons, Augustine and his team sought to explore the role of nerves in the heart attack response. They utilized a groundbreaking technique to make mouse hearts transparent, enabling them to observe nerve activity during induced heart attacks by cutting off blood flow.
The study revealed novel clusters of sensory neurons that extend from the vagus nerve and tightly encompass the ventricles, particularly in areas damaged by lack of blood flow. Interestingly, while few nerve fibers existed prior to the heart attack, their numbers surged significantly post-incident, suggesting that the heart stimulates the growth of these neurons during recovery.
In a key experiment, Augustine’s team selectively turned off these nerves, which halted signaling to the brain, resulting in significantly smaller damaged areas in the heart. “The recovery is truly remarkable,” Augustine noted.
Patients recovering from a heart attack often require surgical interventions to restore vital blood flow and minimize further tissue damage. However, the discovery of these new neurons could pave the way for future medications, particularly in scenarios where immediate surgery is impractical.
Furthermore, the signals from these neurons activated brain regions associated with the stress response, triggering the immune system to direct its cells to the heart. While these immune cells help form scar tissue necessary for repairing damaged muscle, excessive scarring can compromise heart function and lead to heart failure. Augustine and colleagues identified alternative methods to facilitate healing in mice post-heart attack by effectively blocking this immune response early on.
Recent decades have indicated that communication occurs between the heart, brain, and immune system during a heart attack. The difference now is that researchers possess advanced tools to analyze changes at the neuron level. Matthew Kay from George Washington University noted, “This presents an intriguing opportunity for developing new treatments for heart attack patients, potentially including gene therapy.”
Current medical practices frequently include beta-blockers to assist in the healing process following heart attack-induced tissue damage. These findings clarify the mechanism by which beta-blockers influence the feedback loops within nervous and immune systems activated during heart attacks.
As Robin Choudhury from the University of Oxford remarked, “We might have already intervened with the newly discovered routes.” Nevertheless, he cautioned that this pathway likely interacts with various other immune signals and cells that remain not fully understood.
Moreover, factors like genetics, gender differences, and conditions such as diabetes or hypertension could affect the evolution of this newly identified response. Hence, determining when and if a pathway is active in a wider population remains essential before crafting targeted drugs, Choudhury added.
Unlocking the Potential: Does Heat Therapy Enhance Brain Function?
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As an enthusiast of cold water swimming, I previously explored its brain benefits. However, the emerging evidence on heat therapy fascinated me—particularly regarding its neurological advantages. This prompted a deeper investigation into the subject.
During my last trip to Finland and Sweden, I immersed myself in their sauna culture, learning that ‘sauna’ is pronounced ‘sow-na’ (with ‘ow’ rhyming with ‘how’), contrasting my South East London pronunciation.
Finnish saunas, reaching temperatures of 70°C to 110°C (158°F to 230°F) with low humidity, are extensively studied. Regular sauna use correlates with numerous physical benefits, such as reduced risks of high blood pressure, muscle disorders, and respiratory diseases. Recent research also identifies significant cognitive benefits, including fewer headaches, improved mental health, better sleep quality, and a decreased risk of dementia.
A large-scale study involving nearly 14,000 participants aged 30 to 69 tracked sauna habits over 39 years. The findings revealed that those who frequented saunas nine to twelve times a month exhibited a 19 percent reduction in dementia risk compared to those who visited less than four times a month.
Moreover, sauna bathing appears linked to various cognitive enhancements. For instance, a small trial involving 37 adults with chronic headaches compared those receiving headache management advice to participants who regularly attended saunas. The sauna group reported significantly reduced headache intensity.
Regular sauna use is also associated with lower risks of psychosis and increased vitality and social functioning in elderly individuals, reinforcing its potential cognitive benefits.
However, it’s crucial to recognize that not all heat treatments yield the same results. Various forms of heat therapy exist, each offering distinct benefits. For example, a trial with 26 individuals diagnosed with major depressive disorder showed that those receiving infrared heating sessions reported significant symptom reductions over six weeks compared to a sham treatment.
How Does Heat Therapy Benefit Brain Health?
Heat therapy’s efficacy appears closely linked to its anti-inflammatory effects. In a study following 2,269 middle-aged Finnish men, researchers found that individuals engaging in frequent sauna use exhibited reduced levels of inflammation, a factor significantly associated with depression and cognitive decline.
Another mechanism involves heat shock proteins, which are produced when body temperature rises during sauna use or exercise. These proteins help prevent misfolding of other proteins—a common feature in many neurological disorders, including Alzheimer’s disease.
Enhanced blood circulation also plays a role; heat exposure dilates blood vessels, thereby improving cardiovascular health. This indirect benefit to brain health can decrease risks associated with vascular dementia and Alzheimer’s disease.
Additionally, saunas may elevate brain-derived neurotrophic factor (BDNF) levels, vital for neuron growth. In an experiment with 34 men, participants receiving 12 to 24 sessions of infrared therapy displayed significantly higher BDNF levels and improved mental well-being compared to those doing low-intensity workouts.
Can Saunas Enhance Cognitive Skills?
Beyond long-term neurological advantages, the immediate effects of sauna sessions are promising. A study involving 16 men revealed that brain activity post-sauna sessions resembled a relaxed state, indicating potential improvements in task efficiency. Researchers suggest that heat therapy may help extend mental work capacity over prolonged periods.
However, excessive heat exposure can lead to fatigue and reduced cognitive function. Studies indicate that high-temperature environments may impair memory consolidation, making saunas less suitable for study sessions.
If you’re exploring heat therapy, check guidelines from the British Sauna Association to ensure safety, including limiting duration and staying hydrated.
Do Hot Baths Offer Similar Benefits?
If you lack access to saunas, could hot baths serve as an alternative? While they may partially replicate sauna benefits, the evidence is still inconclusive. According to Ali Qadiri from West Virginia University, warm baths do elevate core body temperature and can improve mood and relaxation. Still, he cautions that robust data on saunas and dementia prevention far outweighs that for baths.
My local lake offers both cold water swimming and sauna experiences, prompting me to consider their combined effects. A Japanese study on the practice known as totonou, or alternating between hot saunas and cold baths, revealed enhancements in relaxation and reduced alertness after several rounds.
While more research is needed to determine if this combination is more effective than using heat or cold therapy alone, the overall evidence supports potential cognitive boosts from regular sauna visits, reinforcing my commitment to explore more heat and cold therapy options.
A groundbreaking study reveals that astronauts’ brains can experience changes in shape and position during their time in space, presenting significant implications for NASA’s objectives of long-duration missions to the Moon and Mars.
Published on Monday in the Journal Proceedings of the National Academy of Sciences, the research indicates that astronauts’ brains tilted upward after spaceflight, deviating from their normal Earth position and shifting within their skulls. The study identified that areas associated with sensory functions, motion sickness, disorientation, and balance were notably affected.
This research contributes to the evolving field of aerospace medicine, which investigates the physical toll spaceflight and microgravity exert on the human body. Such insights are crucial for planning NASA’s ambitious projects to establish a base on the Moon and conduct crewed missions deeper into the solar system.
“Understanding these changes and their implications is vital for ensuring astronauts’ safety and health, as well as ensuring their longevity in space,” stated Rachel Seidler, a professor at the University of Florida and co-author of the study.
Seidler and her team examined MRI scans of 26 astronauts taken before and after their missions in orbit. The duration of spaceflight varied from a few weeks (for Space Shuttle missions) to about six months (the typical length for International Space Station missions). Some astronauts even spent a year aboard the station.
“Those who spent a year in space exhibited the most significant changes,” Seidler revealed. “We observed noticeable alterations even in astronauts who were in space for just two weeks, indicating that duration is a key factor.”
She added that among astronauts who remained in microgravity for over six months, the upward movement of their brains was “quite widespread,” particularly within the upper brain structures.
“The movement is in the range of a few millimeters. While this might not seem significant, in terms of brain dynamics, it truly is,” she noted.
Seidler pointed out that the observed brain changes often lead to “sensory conflicts” while astronauts are in space, resulting in temporary disorientation and motion sickness. Upon returning to Earth, such changes may also contribute to balance issues as astronauts readjust to the planet’s gravity. However, the study did not report any severe symptoms, like headaches or cognitive impairment, either during or after spaceflight.
“That was a surprise to me,” Seidler remarked.
For a comparative analysis, the research team also examined brain scans of 24 civilian participants who underwent bed rest for up to 60 days with their heads positioned at a 6-degree angle downward, mimicking microgravity conditions. Similar changes in brain position and shape were observed, yet astronauts’ brains displayed a more pronounced upward shift.
Dr. Mark Rosenberg, assistant professor of neurology and director of the Aerospace and Performance Neurology Program at the Medical University of South Carolina, emphasized that while the effects of spaceflight on the brain have been recognized, Seidler’s study is pioneering in documenting how these upward shifts impact astronauts both in space and upon their return to Earth.
“While we knew the brain shifted upward, we needed to explore any operational consequences,” said Rosenberg, who did not participate in the study. “This work helps clarify those relationships.”
The findings prompt additional questions for future studies, including whether brain changes differ between male and female astronauts and whether the age of crew members influences these changes. However, gathering a comprehensive dataset is challenged by the limited number of astronauts launched to the International Space Station each year, a demographic that has predominantly been male.
Further research is essential to establish whether the observed brain changes have long-term repercussions.
Currently, these changes do not appear to be permanent, similar to various physiological changes astronauts experience post-mission, such as bone density loss, muscle atrophy, and fluid redistribution. Once the body readjusts to Earth’s gravity, conditions largely normalize, Rosenberg explained.
However, it remains uncertain whether different gravitational environments might introduce new complications.
“If an astronaut were on Mars, which has one-third of Earth’s gravity, or on the Moon, with one-sixth of Earth’s gravity, how much longer would it take to return to normal?” Rosenberg queried.
Both he and Seidler assert that the current findings shouldn’t deter humans from spending extended periods in space. It is crucial, however, to comprehend any potential long-lasting damage and identify strategies to mitigate it.
“Whether we acknowledge it or not, we are destined to become a spacefaring species,” Rosenberg concluded. “It’s merely a matter of time. These are just some of the essential questions we need to address.”
Simulating the human brain involves using advanced computing power to model billions of neurons, aiming to replicate the intricacies of real brain function. Researchers aspire to enhance brain simulations, uncovering secrets of cognition with enhanced understanding of neuronal wiring.
Historically, researchers have focused on isolating specific brain regions for simulations to elucidate particular functions. However, a comprehensive model encompassing the entire brain has yet to be achieved. As Markus Diesmann from the Jülich Research Center in Germany notes, “This is now changing.”
This shift is largely due to the emergence of state-of-the-art supercomputers, nearing exascale capabilities—performing billions of operations per second. Currently, only four such machines exist, according to the Top 500 list. Diesmann’s team is set to execute extensive brain simulations on one such supercomputer, named JUPITER (Joint Venture Pioneer for Innovative Exascale Research in Germany).
Recently, Diesmann and colleagues demonstrated that a simple model of brain neurons and their synapses, known as a spiking neural network, can be configured to leverage JUPITER’s thousands of GPUs. This scaling can achieve 20 billion neurons and 100 trillion connections, effectively mimicking the human cerebral cortex, the hub of higher brain functions.
These simulations promise more impactful outcomes than previous models of smaller brains such as fruit flies. Recent insights from large language models reveal that larger systems exhibit behaviors unattainable in their smaller counterparts. “We recognize that expansive networks demonstrate qualitatively different capabilities than their reduced size equivalents,” asserts Diesmann. “It’s evident that larger networks offer unique functionalities.”
Thomas Novotny from the University of Sussex emphasizes that downscaling risks omitting crucial characteristics entirely. “Conducting full-scale simulations is vital; without it, we can’t truly replicate reality,” Novotny states.
The model in development at JUPITER is founded on empirical data from limited neuron and synapse experiments in humans. As Johanna Cenk, a collaborator with Diesmann at Sussex, explains, “We have anatomical data constraints coupled with substantial computational power.”
Comprehensive brain simulations could facilitate tests of foundational theories regarding memory formation—an endeavor impractical with miniature models or actual brains. Testing such theories might involve inputting images to observe neural responses and analyze alterations in memory formation with varying brain sizes. Furthermore, this approach could aid in drug testing, such as assessing impacts on a model of epilepsy characterized by abnormal brain activity.
The enhanced computational capabilities enable rapid brain simulations, thereby assisting researchers in understanding gradual processes such as learning, as noted by Senk. Additionally, researchers can devise more intricate biological models detailing neuronal changes and firings.
Nonetheless, despite the ability to simulate vast brain networks, Novotny acknowledges considerable gaps in knowledge. Even simplified whole-brain models for organisms like fruit flies fail to replicate authentic animal behavior.
Simulations run on supercomputers are fundamentally limited, lacking essential features inherent to real brains, such as real-world environmental inputs. “While we can simulate brain size, we cannot fully replicate a functional brain,” warns Novotny.
Humans have larger brains relative to body size compared to other primates, which leads to a higher glucose demand that may be supported by gut microbiota changes influencing host metabolism. In this study, we investigated this hypothesis by inoculating germ-free mice with gut bacteria from three primate species with varying brain sizes. Notably, the brain gene expression in mice receiving human and macaque gut microbes mirrored patterns found in the respective primate brains. Human gut microbes enhanced glucose production and utilization in the mouse brains, suggesting that differences in gut microbiota across species can impact brain metabolism, indicating that gut microbiota may help meet the energy needs of large primate brains.
Decasian et al. provided groundbreaking data showing that gut microbiome shapes brain function differences among primates. Image credit: DeCasien et al., doi: 10.1073/pnas.2426232122.
“Our research demonstrates that microbes influence traits critical for understanding evolution, especially regarding the evolution of the human brain,” stated Katie Amato, lead author and researcher at Northwestern University.
This study builds upon prior research revealing that introducing gut microbes from larger-brained primates into mice leads to enhanced metabolic energy within the host microbiome—a fundamental requirement for supporting the development and function of energetically costly large brains.
The researchers aimed to examine how gut microbes from primates of varying brain sizes affect host brain function. In a controlled laboratory setting, they transplanted gut bacteria from two large-brained primates (humans and squirrel monkeys) and a smaller-brained primate (macaque) into germ-free mice.
Within eight weeks, mice with gut microbes from smaller-brained primates exhibited distinct brain function compared to those with microbes from larger-brained primates.
Results indicated that mice hosting larger-brained microbes demonstrated increased expression of genes linked to energy production and synaptic plasticity, vital for the brain’s learning processes. Conversely, gene expression associated with these processes was diminished in mice hosting smaller-brained primate microbes.
“Interestingly, we compared our findings from mouse brains with actual macaque and human brain data, and, to our surprise, many of the gene expression patterns were remarkably similar,” Dr. Amato remarked.
“This means we could alter the mouse brain to resemble that of the primate from which the microbial sample was derived.”
Another notable discovery was the identification of gene expression patterns associated with ADHD, schizophrenia, bipolar disorder, and autism in mice with gut microbes from smaller-brained primates.
Although previous research has suggested correlations between conditions like autism and gut microbiome composition, definitive evidence linking microbiota to these conditions has been lacking.
“Our study further supports the idea that microbes may play a role in these disorders, emphasizing that the gut microbiome influences brain function during developmental stages,” Dr. Amato explained.
“We can speculate that exposure to ‘harmful’ microorganisms could alter human brain development, possibly leading to the onset of these disorders. Essentially, if critical human microorganisms are absent in early stages, functional brain changes may occur, increasing the risk of disorder manifestations.”
These groundbreaking findings will be published in today’s Proceedings of the National Academy of Sciences.
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Alex R. Decassian et al. 2026. Primate gut microbiota induces evolutionarily significant changes in neurodevelopment in mice. PNAS 123(2): e2426232122; doi: 10.1073/pnas.2426232122
When neurons in the brain are active, they generate waste products.
Credit: Nick Veasey/Science Photo Library/Alamy
As we embrace the joy of the Christmas season, many are already thinking about detox plans for the new year, such as reducing movie watching or cutting back on alcohol. This leads to an interesting query: can we apply similar detox methods to our brains? After the festivities, how can we clear away any cognitive clutter?
The brain is naturally equipped to detoxify itself daily, flushing out accumulated metabolic waste that could be harmful. But can we assist in this vital process, potentially shielding ourselves from age-related cognitive decline and dementia?
Let’s delve into the glymphatic system, a newly uncovered pathway responsible for detoxification. This system effectively “sucks” away undesirable proteins and waste from the spaces between neurons, channeling them into cerebrospinal fluid (CSF).
“CSF circulates much like water in a dishwasher,” explains Maha Alattar from Virginia Commonwealth University.
This fluid systematically drains waste into lymph nodes, eventually allowing it to exit the body through the veins.
While the connection between the glymphatic and lymphatic systems is still not fully understood, researchers are increasingly focused on ways to optimize the glymphatic process. Enhancing this system could prove pivotal in combating cognitive decline and promoting healthy aging. Accumulation of metabolic waste in the brain is linked to symptoms such as declining cognitive function, increasing the risk of dementia and expediting Alzheimer’s and Parkinson’s disease symptoms.
“The glymphatic system is fascinating,” says Nandakumar Narayanan from the University of Iowa Health Care. “Numerous innovative research efforts aim to better understand and quantify glymphatic functions, shedding light on human health and disease.”
Enhancing the Brain’s Waste Removal System
Are there ways we can enhance this waste disposal mechanism? Recent studies indicate that lifestyle changes may significantly impact its efficiency.
“The most proven method to boost glymphatic clearance is sleep,” notes Dr. Lila Landovsky from the University of Tasmania.
The glymphatic system is predominantly inactive during waking hours but reaches peak activity during sleep. For instance, in mice, CSF flow surges by about 60% while they sleep, enabling the removal of beta-amyloid, a protein linked to Alzheimer’s disease.
Though studies have yet to definitively establish that glymphatic activation directly prevents dementia, “the hypothesis is strengthened by evident links between factors that impair glymphatic clearance—such as sleep disturbances and sedentary behavior—and an increased risk for neurodegenerative conditions,” states Landowski.
The position in which we sleep could also affect glymphatic function. In 2015, Helen Benveniste and her team found that sleeping on one’s side improved glymphatic clearance in mice more effectively than sleeping on the back or stomach. While this has not yet been tested in humans, many types of dementia show strong associations with sleep disorders, suggesting sleep positions may be important in our fight against dementia.
Additional Strategies to Enhance Brain Detox
Emerging evidence suggests that other lifestyle choices, such as regular exercise, may also bolster glymphatic function. In April, a study involving 37 adults highlighted that only participants who completed a 12-week stationary cycling program experienced noticeable increases in glymphatic drainage, as observed through brain imaging.
“Research in mice indicates that glymphatic clearance can roughly double after five weeks of regular exercise in comparison to sedentary mice,” says Landowski. “However, short-term studies in mice have yet to be performed.”
Further examination of the glymphatic system may uncover additional methods to enhance its function. Lymphatic vessels connected to CSF are located deep in the neck, making direct manipulation challenging, but researchers led by Ko Young Gu at the Korea Institute of Science and Technology have identified another lymphatic network directly beneath the skin of monkeys and mice’s facial and neck areas.
In experiments, gentle downward stroking of the face and neck in mice tripled CSF flow, effectively rejuvenating older animals’ flow to a more youthful state.
Similar vessels have been detected in human cadavers, suggesting that facial and neck massages could potentially enhance CSF flow, aiding in glymphatic clearance. Nonetheless, more research is needed to substantiate these claims and verify whether this enhanced flow can shield against neurodegenerative disorders.
Promising Evidence Supporting Yoga and Breathing Techniques
One exercise that should not be overlooked is yoga breathing. Hamid Jalillian from the University of California, Irvine, notes that diaphragmatic breathing has robust evidence supporting its ability to increase CSF velocity, effectively activating a glymphatic “rinse cycle.”
Diaphragmatic breathing is characterized by keeping the chest relatively still while moving the abdomen outward and lowering the diaphragm as you inhale through your nose. Conclude the cycle by exhaling through pursed lips while retracting your belly.
Unexplored Potential
Despite the enthusiasm surrounding the glymphatic system, our comprehension of its intricate workings is still developing. Not everyone is convinced we possess enough knowledge to prescribe specific interventions at this time. “We are far from being able to accurately predict how a specific intervention, like exercise, will influence the glymphatic system. There are limited studies in both mice and small human populations, but nothing large-scale and conclusive,” cautions Narayanan.
Nevertheless, there is a sense of optimism. “The potential is immense, but these studies require meticulous and thorough execution,” he concludes.
For now, I’ll concentrate on essential routines—prioritizing quality sleep and regular exercise. These habits are crucial for overall health, but should glymphatic research hold true, they may soon play an even more critical role in keeping my brain clear, not just in the new year, but for years to come.
“I’ve never needed a great excuse to jump into a chilly lake…”
Kaisa Swanson/Alamy
My days are filled with small rituals. Each morning, I blend a spoonful of creatine in water, enjoying it alongside my multivitamin, followed by some plain yogurt rich in beneficial bacteria. Meanwhile, the kids feast on homemade cereal, sip kefir, and practice their Spanish on Duolingo. After school drop-off, I dive into a cold pond, then warm up in the sauna before heading to work. I also make it a point to add sauerkraut to my lunch and take quick walks in the park.
On reflection, it might seem a bit off-putting. The quintessential “wellness enthusiast meets middle-aged neuroscientist.” But this cozy routine is vastly different from a year ago, when the kids were munching on sugary cereal and I was sustained solely by caffeine while buried in my computer, often devoid of sunlight.
This newfound focus on well-being stems from a year-long quest for research-backed methods to enhance my brain health, from boosting cognitive reserves to nurturing a healthy microbiome. Observing my current situation reveals that minor tweaks can lead to substantial changes.
A key insight I’ve gathered from Dr. Joan Manson and other physicians at Brigham and Women’s Hospital in Massachusetts is that a daily multivitamin can significantly slow cognitive decline in older adults by over 50 percent. When I inquired about other supplements beneficial for brain health, creatine stood out because it offers energy precisely when our brains require it.
However, the most significant shift didn’t come from my supplement collection, but rather from my grocery list. Conversations with neuroscientists and nutritionists have made me keenly aware of the importance of maintaining our microbiome. Consequently, my family embraced epidemiologist Tim Spector’s guidance to incorporate three fermented foods daily, eliminate ultra-processed breakfast options, and enjoy a diverse range of whole foods in our meals.
Despite my long-standing enjoyment of cold lake swims or sauna sessions, science has equipped me with compelling reasons to make these activities a priority this year. Cold and heat exposure has been shown to combat inflammation and stress while enhancing connections within brain networks that govern emotions, decision-making, and attention, which may in turn bolster mental health.
Emphasizing outdoor time has also become a family goal. I’ve discovered that gardening enhances the diversity of our gut’s beneficial bacteria, while walking in the woods can boost memory, cognition, and possibly stave off depression.
At home, we persist with Duolingo, valuing not just its linguistic benefits but also its contributions to cognitive reserve—the brain’s defense against aging. I’m also returning to playing the piano and exploring other creative outlets. I recall what Dr. Ellen Bialystok, a professor at York University in Canada, advised: “What challenges the brain is beneficial for the brain.”
The most astonishing aspect has been the rapid emergence of results. While some habits serve as long-term investments in cognitive health, I suspect others have delivered immediate benefits, such as helping my children feel more relaxed, diminish brain fog, and gain energy. It may be placebo, yet something is certainly effective.
Next year, we plan to keep experimenting. Let’s make it a year focused on discovering simple ways to promote brain growth. Now, where’s that kombucha?
Noise-canceling headphones function by utilizing a microphone that detects external sounds. Through sophisticated electronics, these sounds are ‘cancelled’ by playing an inverted wave to the listener, which diminishes the audio signal reaching the eardrum.
This mechanism is akin to how a car’s active suspension mitigates vibrations from uneven roads.
The outcome is that listeners enjoy crystal-clear audio with almost no interference from background noise.
Moreover, these headphones help safeguard your ears from high volume levels. By reducing background noise, your device doesn’t need to produce sound as loudly. Hence, parents globally often encourage their children to wear headphones.
Sounds advantageous, right? But then I began hearing stories about young people facing increasing challenges, such as Auditory Processing Disorder (APD).
These individuals frequently struggle to comprehend sounds and speech amidst distracting background noise.
The underlying causes may be linked to a notable rise in young people using noise-canceling headphones and relying on subtitles while watching videos.
Instead of their brains developing typically and learning to filter the noisy environment, they wear noise-canceling headphones for extended periods, regardless of their location, thereby not allowing their brains to adapt properly.
Our brains function like muscles; they evolve in response to external stimuli.
Just as biking 100 miles a day will sculpt your thighs, your auditory processing skills may weaken if you expose yourself solely to pure audio without any background noise, leaving you unable to process multiple sounds simultaneously.
Auditory therapy can be beneficial in retraining the brain, but the optimal approach is to engage more with the world around you before complications develop. Over-isolating ourselves may lead to greater issues.
This article addresses the question (submitted by Mary Watkins): “Can noise-canceling headphones harm your ears?”
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Short-form videos are dominating social media, prompting researchers to explore their impact on engagement and cognitive function. Your brain may even be changing.
From TikTok to Instagram Reels to YouTube Shorts, short videos are integral to platforms like LinkedIn and Substack. However, emerging research indicates a link between heavy short-form video consumption and issues with concentration and self-control.
The initial findings resonate with concerns about “brain rot,” defined by Oxford University Press as “the perceived deterioration of a person’s mental or intellectual condition.” This term has gained such popularity that it was named the word of the year for 2024.
In September, a review of 71 studies found that extensive short-form video use was correlated with cognitive decline, especially in attention span and impulse control, involving nearly 100,000 participants. Published in the American Psychological Association’s Psychological Bulletin, this review also connected heavy consumption to heightened symptoms of depression, anxiety, stress, and loneliness.
Similarly, a paper released in October summarized 14 studies that indicated frequent consumption of short-form videos is linked to shorter attention spans and poorer academic performance. Despite rising concerns, some researchers caution that the long-term effects remain unclear.
James Jackson, a neuropsychologist at Vanderbilt University Medical Center, noted that fear of new technologies is longstanding, whether regarding video games or iconic concerts. He acknowledges legitimate concerns but warns against overreacting. “It’s naive to dismiss worries as just grumpy complaints,” he said.
Jackson emphasized that research indicates extensive short-form video consumption could adversely affect brain function, yet further studies are needed to identify who is most at risk, the long-lasting impact, and the specific harmful mechanisms involved.
ADHD diagnoses in the U.S. are on the rise, with about 1 in 9 children diagnosed by 2022, according to the CDC. Keith Robert Head, a doctoral student at Capella University, suggests that the overlap between ADHD symptoms and risks from short videos deserves attention. “Are these ADHD diagnoses truly ADHD, or merely effects of short video use?” he questioned.
Three experts noted that research on the long-term effects of excessive short-form video use is in its early stages, with international studies revealing links to attention deficits, memory issues, and cognitive fatigue. However, these studies do not establish causation, often capturing only a snapshot in time.
Dr. Nidhi Gupta, a pediatric endocrinologist focused on screen time effects, argues that more research is necessary, particularly concerning older adults who may be more vulnerable. Gupta cautions that cognitive changes associated with short-form media may lead to a new addiction, likening it to “video games and TV on steroids.” She speculated that, just as research on alcohol and drugs took decades to evolve, a similar moral panic around short videos could emerge within the next 5 to 10 years.
Nevertheless, Jackson contends that short-form videos can be beneficial for online learning and community engagement: “The key is balance. If this engagement detracts from healthier practices or fosters isolation, then that becomes a problem.”
Recent findings from neuroscientists reveal that the brain’s structure divides into five main stages throughout a typical person’s life, marked by four significant turning points from birth to death where the brain undergoes reorganization. Brain topology in children evolves from birth up to a crucial transition at age 9, then shifts into adolescence, which generally lasts until around age 32. In your early 30s, the neural wiring transitions to adult mode, marking the longest phase that extends for over 30 years. The third turning point occurs at about age 66, indicating the start of an early aging phase of brain structure, while the late brain phase begins around age 83.
Masry et al. Using a dataset of MRI diffusion scans, they compared the brains of 3,802 individuals aged 0 to 90 years. The dataset maps neural connections by tracking the movement of water molecules through brain tissue. Image credit: Mously et al., doi: 10.1038/s41467-025-65974-8.
“While we know brain wiring plays a crucial role in our development, we still lack a comprehensive understanding of how and why it fluctuates throughout life,” explained Dr. Alexa Mausley, a researcher at the University of Cambridge.
“This study is the first to pinpoint essential stages in brain wiring throughout the human lifespan.”
“These epochs offer vital insight into our brain’s strengths and vulnerabilities at different life stages.”
“Understanding these changes could shed light on why certain developmental challenges arise, such as learning difficulties in early childhood or dementia later in life.”
During the transition from infancy to childhood, strengthened neural networks emerge as the excess of synapses (the connections between neurons) in a baby’s brain diminishes, allowing only the most active synapses to thrive.
The brain rewires in a consistent pattern from birth until approximately age 9.
In this timeframe, the volumes of gray and white matter grow swiftly, resulting in maximal cortical thickness (the distance from the outer gray matter to the inner white matter), with the cortical folds stabilizing.
By the first turning point at age 9, cognitive abilities begin to evolve gradually, and the likelihood of mental health issues becomes more pronounced.
The second stage, adolescence, is characterized by an ongoing increase in white matter volume, leading to an enhancement in the sophistication of the brain’s communication networks, measurable through water diffusion scans.
This phase is marked by improved connectivity efficiency across specific regions and swift communication throughout the brain, correlating with enhanced cognitive performance.
“As expected, neural efficiency is closely linked to shorter pathways, and this efficiency increases throughout adolescence,” Mausley notes.
“These advancements peak in your early 30s, representing the most significant turning point in your lifetime.”
“Around age 32, the change in wiring direction is the most pronounced, and the overall trajectory alteration is greater than at any other turning points.”
“Although the onset of puberty is clearly defined, the conclusion is far harder to identify scientifically.”
“Based solely on neural structure, we found that puberty-related changes in brain structure conclude by the early 30s.”
Post age 32, adulthood enters its longest phase, characterized by a more stable brain structure with no significant turning points for three decades. This aligns with findings indicating an “intellectual and personality plateau.”
Additionally, the researchers observed a greater degree of “segregation” during this phase, indicating a gradual fragmentation of brain regions.
The tipping point at age 66 is more gradual, lacking dramatic structural shifts; however, notable changes in brain network patterns were found around this age on average.
“Our findings indicate a gradual reconfiguration of brain networks that peaks in the mid-60s,” stated Dr. Mausley.
“This is likely linked to aging, as white matter begins to decline, reducing connectivity further.”
“We are currently facing an era where individuals are increasingly at risk for various health conditions impacting the brain, such as high blood pressure.”
The final turning point arises around age 83, ushering in the last stage of brain structure.
Data from this stage is scarce, but a key characteristic is the shift from global to local connectivity as interactions across the brain diminish while reliance on specific regions intensifies.
Professor Duncan Astle of the University of Cambridge remarked: “In reflection, many of us recognize that our lives encompass distinct stages.”
“Interestingly, the brain also navigates through these phases.”
“Numerous neurodevelopmental, mental health, and neurological conditions are tied to the brain’s wiring.”
“In fact, variations in brain wiring can predict challenges with attention, language, memory, and a wide array of other behaviors.”
“Recognizing that structural transformations in the brain occur not in a linear fashion but through several major turning points can assist us in identifying when and how brain wiring may be vulnerable to disruptions.”
a paper detailing the study was published in the journal on November 25. Nature Communications.
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A. Mausley et al. 2025. Topological turning points across the human lifespan. Nat Commun 16, 10055; doi: 10.1038/s41467-025-65974-8
Many people experience unusual bad dreams. If you often wake up feeling anxious and sweaty, you might be concerned whether it’s simply stress or if there’s a deeper issue at play.
Recent research has indicated a link between frequent nightmares and a heightened risk of dementia.
A 2022 study published in Lancet eClinicalMedicine revealed that individuals in middle age who have weekly nightmares are more prone to cognitive decline.
Furthermore, older adults with recurrent nightmares showed an increased likelihood of developing dementia. While this may seem alarming, should it genuinely be a cause for concern?
Individuals with mental health conditions, such as anxiety and depression, are more prone to experiencing bad dreams – Image courtesy of Getty Images
Not necessarily. The study suggests a correlation but does not establish causation. It remains uncertain whether nightmares are early indicators of existing changes in the brain or if sleep disturbances contribute to disease progression.
Other factors could also be at play—individuals suffering from anxiety, depression, and poor sleep (which themselves have ties to elevated dementia risk) are more likely to encounter bad dreams.
What we do know is that sleep is vital for brain health. Regardless of the underlying cause, there’s evidence that chronic sleep disruption or low-quality sleep may elevate the long-term risk of cognitive decline.
The takeaway? Experiencing regular nightmares alone does not serve as a dependable early warning of Alzheimer’s disease.
For now, practicing good sleep hygiene is the most effective initial step—not just for pleasant dreams, but for a healthy brain. Aim for a consistent bedtime, minimize caffeine and alcohol intake, and limit screen time before sleeping.
This article addresses the query (from Aaron Martin of Stoke-on-Trent): “I keep having nightmares.” Should I be worried?”
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As we grow older, our brains undergo significant rewiring.
Recent studies indicate that this transformation takes place in various stages, or “epochs,” as our neural structures evolve, altering how we think and process information.
For the first time, scientists have pinpointed four key turning points in the typical aging brain: ages 9, 32, 66, and 83. During each of these phases, our brains display distinctly different structural characteristics.
The findings were Published Tuesday in Nature Communications, revealing that human cognitive ability does not merely peak and then decline with age. In reality, research suggests that the interval between 9 and 32 years old is the sole period in which our neural networks are increasingly efficient.
In adulthood, from 32 to 66 years, the structure of the average brain stabilizes without significant modifications, leading researchers to believe that intelligence and personality tend to plateau during this time.
Following another turning point, from age 83 and beyond, the brain increasingly relies on specific regions as connections between them slowly deteriorate.
“It’s not a linear progression,” comments lead author, Alexa Maudsley, a postdoctoral researcher at the University of Cambridge. “This marks an initial step in understanding how brain changes differ with age.”
These insights could shed light on why certain mental health and neurological issues emerge during specific rewiring phases.
Rick Betzel, a neuroscience professor at the University of Minnesota and not a part of the study, remarked that while the findings are intriguing, further data is necessary to substantiate the conclusions. He cautioned that the theory might face challenges over time.
“They undertook a very ambitious effort,” Betzel said about the study. “We shall see where things stand in a few years.”
For their research, Maudsley and colleagues examined MRI diffusion scans (images illustrating water molecule movement in the brain) of around 3,800 individuals, ranging from newborns to 90 years old. Their objective was to map neural connections at varying life stages.
In the brain, bundles of nerve fibers that convey signals are encased in fatty tissue called myelin—analogous to wiring or plumbing. Water molecules diffusing into the brain typically travel along these fibers, allowing researchers to identify neural pathways.”
“We can’t open up the skull…we depend on non-invasive techniques,” Betzel mentioned, discussing this form of neuroscience research. “We aim to determine the location of these fiber bundles.”
A groundbreaking study utilized MRI scans to chart the neural networks of an average individual across their lifetime, pinpointing where connections strengthen or weaken. The five “eras” discussed in the paper reflect the neural connections observed by the researchers.
They propose that the initial stage lasts until age nine, during which both gray and white matter rapidly increases. This phase involves the removal of redundant synapses and self-reconstruction.
Between ages 9 and 32, there is an extensive period of rewiring. The brain is characterized by swift communication across its regions and efficient connections.
Most mental health disorders are diagnosed during this interval, Maudsley pointed out. “Is there something about this second phase of life that might predispose individuals to mental health issues?”
From ages 32 to 66, the brain reaches a plateau. It continues to rewire, but this process occurs at a slower and less dramatic pace.
Subsequently, from ages 66 to 83, the brain undergoes “modularization,” where neural networks split into highly interconnected subnetworks with diminished central integration. By age 83, connectivity further declines.
Betzel expressed that the theory presented in this study is likely reflective of people’s experiences with aging and cognition.
“It’s something we naturally resonate with. I have two young kids, and I often think, ‘They’re transitioning out of toddlerhood,'” Betzel remarked. “Science may eventually uncover the truth. But are they precisely at the correct age? I’m not sure.”
Ideally, researchers would gather MRI diffusion data on a large cohort, scanning each individual across their lifespan, but that was unfeasible decades ago due to technological constraints.
Instead, the team amalgamated nine diverse datasets containing neuroimaging from prior studies, striving to harmonize them.
Betzel noted that these datasets vary in quality and methodology, and attempts to align them may obscure essential variations and introduce bias into the findings.
Nonetheless, he acknowledged that the paper’s authors are “thoughtful” and proficient scientists who did their utmost to mitigate that risk.
“Brain networks evolve throughout life, that’s undeniable. But are there five precise moments of transition? I hope you’ll take note of this intriguing notion.”
The wiring of our neurons evolves over the decades
Alexa Mousley, University of Cambridge
Our brain’s functionality isn’t static throughout our lives. We know that our capacity for learning and the risk of cognitive decline fluctuate from infancy to our 90s. Recently, scientists may have uncovered a possible reason for this change. The wiring of our brains seems to experience four key turning points at ages 9, 32, 66, and 83.
Previous studies indicate that our bodies undergo three rapid aging cycles around the ages of 40, 60, and 80. However, the complexity of the brain complicates our understanding.
The brain consists of distinct regions that communicate through white matter tracts. These tracts are wire-like structures formed by long, slender projections known as axons, which extend from neurons, or brain cells. These connections significantly influence cognitive functions, including memory. Nevertheless, it was uncertain if this substantial change in wiring transpires throughout one’s life. “No one has combined multiple metrics to characterize stages of brain wiring,” states Alexa Mousley from Cambridge University.
In an effort to bridge this knowledge gap, Maudsley and his team examined MRI scans of roughly 3,800 individuals from the UK and US, primarily white, spanning ages from newborns to 90 years. These scans were previously gathered as part of various brain imaging initiatives, most of which excluded individuals with neurodegenerative diseases or mental health issues.
The researchers discovered that the brain wiring of individuals reaching 90 years old typically progresses through five significant stages, separated by four primary turning points.
In the initial stage, from birth to age nine, the white matter tracts between brain areas seem to become longer, more intricate, and less efficient. “It takes time for information to travel between regions,” explains Mausley.
This may be due to the abundance of connections in our brains as young children. As we age and gain experiences, we gradually eliminate unused connections. Mausley notes that the brain prioritizes making broader connections, beneficial for activities like piano practice, though at the expense of efficiency.
However, during the second stage, from ages 9 to 32, this trend appears to reverse, potentially driven by the onset of puberty and hormonal shifts affecting brain development. “Suddenly, your brain’s connections become more efficient. Connections become shorter, allowing information to traverse more swiftly,” says Mausley. This could enhance skills such as planning and decision-making, along with improved cognitive abilities like working memory.
The third stage, which spans from 32 to 66 years, is the longest phase. “During this stage, the brain continues to change, albeit at a slower rate,” Mausley explains. Specifically, she notes that connections between regions have a tendency to become less efficient over time. “It’s unclear what exactly triggers this change; however, the 30s often involve significant lifestyle alterations, like starting a family, which may play a role,” she adds. This inefficiency might also stem from general physical wear and tear, as noted by Katia Rubia from King’s College London.
From ages 66 to 83, the connections between neurons in the same brain area tend to remain more stable than those among different regions. “This is noteworthy, especially as the risk of developing conditions like dementia increases during this period,” Mausley remarks.
In the final stage, from ages 83 to 90, connections between brain regions weaken and rely more frequently on “hubs” that link multiple areas. “This indicates that there are fewer resources available to maintain connections at this age, leading the brain to depend on specific areas to serve as hubs,” Mausley explains.
Understanding these alterations in the brain could provide insights into why mental health issues arise, typically before the age of 25, and why individuals over 65 are particularly vulnerable to dementia, she states.
“It’s vital to comprehend the normal stages of structural changes in the brain throughout the human lifespan, so future research can explore deviations that occur in mental health and neurodegenerative disorders,” Rubia notes. “Grasping the causes of these deviations can assist us in pinpointing treatment strategies. For instance, we might examine which environmental factors or chemicals are responsible for these differences and discover methods to counteract them through treatments, policies, and medications.”
Nevertheless, Rubia emphasizes the need for further research to determine whether these findings apply to a more ethnically and geographically diverse population.
Ultrasound can penetrate the skull and reach the brain
Shutterstock/peterschreiber.media
Recent research suggests that pulsed ultrasound waves directed at the brain may enhance survival rates following a specific stroke type by promoting the removal of inflammatory dead blood cells, based on findings from a study involving mice. This technique, which boosts lymphatic drainage efficiency, could also have applications for treating Alzheimer’s disease, with clinical trials anticipated to commence next year.
Hemorrhagic stroke, constitutes around 15% of all strokes and occurs when a blood vessel in the brain bursts, leading to bleeding, disrupting oxygen supply to the brain, and causing cellular damage, which can result in motor and cognitive issues.
Treatments typically involve sealing the ruptured blood vessel with small metal clips and extracting dead red blood cells via a catheter or similar device. Neglecting this procedure can exacerbate inflammation and lead to further tissue damage. However, this method is highly invasive, posing risks of brain damage and infections, as noted by Larg Airan at Stanford University, California.
After an unexpected experience with prolonged ultrasound application during drug activation in mouse brains, Aylan considered whether pulsed ultrasound could be effective in removing the “debris” from the brain. “When I observed the drug’s effects, it appeared to spread throughout the brain, almost as if it were being ‘painted’ over,” he recounted.
To probe this idea, the research team simulated a hemorrhagic stroke by injecting mice with blood from their tails. For three consecutive days, they administered pulsed ultrasound to the skulls of half the mice for 10 minutes each day, while the others received no treatment.
Subsequently, all mice underwent a three-minute test in a water tank divided into four corners, with healthy mice typically turning in either direction 50% of the time. The team discovered that mice treated with ultrasound turned left 39% of the time, compared to 27% for the control group. Additionally, treated mice exhibited stronger grips on a metal bar than their untreated counterparts, indicating they suffered less brain damage, a conclusion that was later substantiated through brain slice analyses conducted post-euthanasia.
One week following the blood injection, around half of the control group mice perished, compared to only one-fifth of the ultrasound-treated group. A rapid increase in survival rates was noted, with an approximately 30 percentage point improvement achieved through just three 10-minute ultrasound treatments, according to Airan.
Further insights revealed that the ultrasound pulses triggered pressure-sensitive proteins in microglia, the brain’s immune cells, reducing their inflammation and enhancing their ability to clear dead red blood cells. Additionally, this technique improved the flow of cerebrospinal fluid, facilitating the removal of dead cells to lymph nodes in the neck, which are part of the lymphatic system responsible for eliminating metabolic waste.
While more investigations are necessary, this method might also have the potential to address various brain disorders. “If ultrasound can efficiently remove larger red blood cells from the brain, it stands to reason it could also eliminate smaller toxic proteins, such as the misfolded tau associated with Parkinson’s and Alzheimer’s diseases,” Aylan explained.
Experts are impressed with this promising research due to its non-invasive nature. Kathleen Caron from the University of North Carolina at Chapel Hill noted that the lymphatic systems in mice and humans show considerable similarities, indicating this approach could be applicable in human cases as well.
The use of ultrasonic irradiation is considered safe, and while research is ongoing to confirm these findings, Aylan is optimistic about the lack of unforeseen side effects from this treatment.
Ultimately, the research team aspires to test this technique on individuals suffering from hemorrhagic strokes that necessitate urgent intervention. They aim to gather additional data on its safety and efficacy for Alzheimer’s patients, with trials projected to begin next year, according to Aylan.
Contemporary artificial intelligence (AI) models are vast, relying on energy-hungry server farms and operating on billions of parameters trained on extensive datasets.
Is this the only way forward? It seems not. One of the most exciting prospects for the future of machine intelligence began with something significantly smaller: the minute worm.
Inspired by Caenorhabditis elegans, a tiny creature measuring just a millimeter and possessing only 302 neurons, researchers have designed a “liquid neural network,” a radically different type of AI capable of learning, adapting, and reasoning on a single device.
“I wanted to understand human intelligence,” said Dr. Ramin Hassani, co-founder and CEO of Liquid AI, a pioneering company in this mini-revolution, as reported by BBC Science Focus. “However, we found that there was minimal information available about the human brain or even those of rats and monkeys.”
At that point, the most thoroughly mapped nervous system belonged to C. elegans, providing a starting point for Hassani and his team.
The appeal of C. elegans lay not in its behavior, but in its “neurodynamics,” or how its cells communicated with one another.
The neurons in this worm’s brain transmit information through analog signals rather than the sharp electrical spikes typical of larger animals. As nervous systems developed and organisms increased in size, spiking neurons became more efficient for information transmission over distances.
Nonetheless, the origins of human neural computation trace back to the analog realm.
For Hassani, this was an enlightening discovery. “Biology provides a unique lens to refine our possibilities,” he explained. “After billions of years of evolution, every viable method to create efficient algorithms has been considered.”
Instead of emulating the worm’s neurons one by one, Hassani and his collaborators aimed to capture their essence of flexibility, feedback, and adaptability.
“We’re not practicing biomimicry,” he emphasized. “We draw inspiration from nature, physics, and neuroscience to enhance artificial neural networks.”
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What characterizes them as “liquid”?
Conventional neural networks, like those powering today’s chatbots and image generators, tend to be very static. Once trained, their internal connections are fixed and not easily altered through experience.
Liquid neural networks, however, offer a different approach. “They are a fluid that enhances adaptability,” said Hassani. “These systems can remain dynamic throughout computation.”
To illustrate, he referenced self-driving cars. When driving in rain, adjustments must be made even if visibility (or input data) becomes obscured. Thus, the system must adapt and be sufficiently flexible.
Traditional neural networks operate in a strictly unidirectional, deterministic fashion — the same input always results in the same output, and data flow is linear within the layer. While this is a simplified view, the point is clear.
Liquid neural networks function differently: neurons can influence one another bidirectionally, resulting in a more dynamic system. Consequently, these models behave stochastically. Providing the same input twice may yield slightly varied responses, akin to biological systems.
C. elegans is a small worm, about 1 mm long, that thrives in moist, nutrient-rich settings like soil, compost piles, and decaying vegetation. – Credit: iStock / Getty Images Plus
“Traditional networks take input, process it, and deliver results,” stated Hassani. “In contrast, liquid neural networks perform calculations while simultaneously adjusting their processing methods with each new input.”
The mathematics behind these networks is complex. Earlier versions were slow due to the reliance on intricate equations requiring sequential resolution before yielding an output.
In 2022, Hassani and his team published a study in Nature Machine Intelligence, introducing an approximate way to manage these equations without heavy computation.
This innovation significantly enhanced the liquid model’s speed and efficiency while preserving the biological adaptability that conventional AI systems often lack.
More compact, eco-friendly, and intelligent
This adaptability allows liquid models to store considerably more information within smaller infrastructures.
“Ultimately, what defines an AI system is its ability to process vast amounts of data and condense it into this algorithmic framework,” Hassani remarked.
“If your system is constrained by static parameters, your capabilities are limited. However, with dynamic flexibility, one can effectively encapsulate greater intelligence within the system.”
He referred to this as the “liquid method of calculation.” Consequently, models thousands of times smaller than today’s large language models can perform comparably or even exceed them in specific tasks.
Professor Peter Bentley, a computer scientist at University College London, specializing in biologically-inspired computing, noted that this transformation is vital: “AI is presently dominated by energy-intensive models relying on antiquated concepts of neuron network simulation.”
“Fewer neurons translate to a smaller model, which reduces computational demand and energy consumption. The capacity for ongoing learning is crucial, something current large models struggle to achieve.”
As Hassani stated, “You can essentially integrate one of our systems into your coffee machine.”
“If it can operate within the smallest computational unit, it can be hosted anywhere, opening up a vast array of opportunities.”
Liquid models are compact enough to run directly on devices like smart glasses or self-driving cars, with no need for cloud connectivity. – Credit: iStock / Getty Images Plus
AI that fits in your pocket and on your face
Liquid AI is actively developing these systems for real-world application. One collaboration involves smart glasses that operate directly on users’ devices, while others are focused on self-driving cars and language translators functioning on smartphones.
Hassani, a regular glasses wearer, pointed out that although smart glasses sound appealing, users may not want every detail in their surroundings sent to a server for processing (consider bathroom breaks).
This is where Liquid Networks excel. They can operate on minimal hardware, allowing for local data processing, enhancing privacy, and reducing energy consumption.
This also promotes AI independence. “Humans don’t depend on one another for function,” Hassani explained. “Yet they communicate. I envision future devices that maintain this independence while being capable of sharing information.”
Hassani dubbed this evolution “physical AI,” referring to intelligence that extends beyond cloud settings to engage with the physical realm. Realizing this form of intelligence could make the sci-fi vision of robots a reality without needing constant internet access.
However, there are some limitations. Liquid systems only function with “time series” data, meaning they cannot process static images, which traditional AI excels at, but they require continuous data like video.
According to Bentley, this limitation is not as restrictive as it appears. “Time series data may sound limiting, but it’s quite the opposite. Most real-world data has a temporal component or evolves over time, encompassing video, audio, financial exchanges, robotic sensors, and much more.”
Hassani also acknowledged that these systems aren’t designed for groundbreaking scientific advancements, such as identifying new energy sources or treatments. This research domain will likely remain with larger models.
Yet, that isn’t the primary focus. Instead, this technology aims to render AI more efficient, interpretable, and human-like while adapting it to fit various real-world applications. And it all originated from a small worm quietly moving through the soil.
Several hominid species — Australopithecus africanus, Paranthropus robustus, early homo varieties, Gigantopithecus brachy, Pongo, papio, homo neanderthalensis, and homo sapiens — have undergone significant lead exposure over two million years, as revealed by a new analysis of fossilized teeth collected from Africa, Asia, Oceania, and Europe. This finding challenges the notion that lead exposure is merely a contemporary issue.
Lead exposure affecting modern humans and their ancestors. Image credit: J. Gregory/Mount Sinai Health System.
Professor Renaud Joannes Boyau from Southern Cross University remarked: “Our findings indicate that lead exposure has been integral to human evolution, not just a byproduct of the industrial revolution.”
“This suggests that our ancestors’ brain development was influenced by toxic metals, potentially shaping their social dynamics and cognitive functions over millennia.”
The team analyzed 51 fossil samples globally utilizing a carefully validated laser ablation microspatial sampling technique, encompassing species like Australopithecus africanus, Paranthropus robustus, early homo variants, Gigantopithecus brachy, Pongo, papio, homo neanderthalensis, and homo sapiens.
Signs of transient lead exposure were evident in 73% of the specimens analyzed (compared to 71% in humans). This included findings on Australopithecus, Paranthropus, and homo species.
Some of the earliest geological samples from Gigantopithecus brachy, believed to be around 1.8 million years old from the early Pleistocene and 1 million years old from the mid-Pleistocene, displayed recurrent lead exposure events interspersed with periods of little to no lead uptake.
To further explore the impact of ancient lead exposure on brain development, researchers also conducted laboratory studies.
Australopithecus africanus. Image credit: JM Salas / CC BY-SA 3.0.” width=”580″ height=”627″ srcset=”https://cdn.sci.news/images/2015/01/image_2428-Australopithecus-africanus.jpg 580w, https://cdn.sci.news/images/2015/01/image_2428-Australopithecus-africanus-277×300.jpg 277w” sizes=”(max-width: 580px) 100vw, 580px”/>
Australopithecus africanus. Image credit: JM Salas / CC BY-SA 3.0.
Using human brain organoids (miniature brain models grown in the lab), researchers examined the effects of lead on a crucial developmental gene named NOVA1, recognized for modulating gene expression during neurodevelopment in response to lead exposure.
The modern iteration of NOVA1 has undergone changes distinct from those seen in Neanderthals and other extinct hominins, with the reasons for this evolution remaining unclear until now.
In organoids with ancestral versions of NOVA1, exposure to lead significantly altered neural activity in relation to Fox P2 — a gene involved in the functionality of brain regions critical for language and speech development.
This effect was less pronounced in modern organoids with NOVA1 mutations.
“These findings indicate that our variant of NOVA1 might have conferred a protective advantage against the detrimental neurological effects of lead,” stated Alison Muotri, a professor at the University of California, San Diego.
“This exemplifies how environmental pressures, such as lead toxicity, can drive genetic evolution, enhancing our capacity for survival and verbal communication while also affecting our susceptibility to contemporary lead exposure.”
An artistic rendition of a Gigantopithecus brachy herd in the forests of southern China. Image credit: Garcia / Joannes-Boyau, Southern Cross University.
Genetic and proteomic analyses in this study revealed that lead exposure in archaic variant organoids disrupts pathways vital for neurodevelopment, social behavior, and communication.
Alterations in Fox P2 activity indicate a possible correlation between ancient lead exposure and the advanced language abilities found in modern humans.
“This research highlights the role environmental exposures have played in human evolution,” stated Professor Manish Arora from the Icahn School of Medicine at Mount Sinai.
“The insight that exposure to toxic substances may conjure survival advantages in the context of interspecific competition introduces a fresh perspective in environmental medicine, prompting investigations into the evolutionary origins of disorders linked to such exposures.”
For more information, refer to the study published in the journal Science Advances.
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Renaud Joannes Boyau et al. 2025. Effects of intermittent lead exposure on hominid brain evolution. Science Advances 11(42); doi: 10.1126/sciadv.adr1524
Homo sapiens may have developed greater tolerance to lead exposure compared to other hominids
frantic00/Shutterstock
Research on fossilized teeth indicates that ancient humans were exposed to harmful lead for over two million years, suggesting that modern humans might have adapted to handle this toxic metal more effectively than their predecessors.
Traditionally, lead poisoning was associated with modern issues such as industrialization, poor mining techniques, and lead additives in fuels. Fortunately, efforts to phase out lead exposure have been underway since the 1980s.
This toxin is particularly harmful to children, hindering physical and cognitive growth, while adults may experience a range of serious physical and mental health issues.
Dr. Renaud Joanne Bois and colleagues from Southern Cross University in Lismore, Australia, aimed to investigate whether our ancient ancestors faced similar lead exposure.
They examined 51 fossilized hominin teeth, representing species such as Australopithecus africanus, Paranthropus robustus, Gigantopithecus black, Homo neanderthalensis, and Homo sapiens. The fossils were sourced from regions including Australia, Southeast Asia, China, South Africa, and France.
The research team utilized laser ablation techniques to identify lead concentrations in the teeth, revealing layers of lead that accumulated during the growth of these hominids. This exposure could be attributed to environmental contaminants, such as polluted water, soil, or volcanic eruptions.
Dr. Joanne Boyau noted the surprising levels of lead discovered within the teeth. For instance, Gigantopithecus, a massive ancestral relative of today’s orangutans, primarily lived in what is now China. “If current humans exhibit similar lead levels, it indicates considerable exposure from industrial activities,” she remarked.
The research then shifted focus to understanding how both modern humans and Neanderthals managed lead exposure. The team created lab-grown brain models called organoids to analyze differences in the NOVA1 gene in both species, subsequently assessing the effects of lead neurotoxicity on these organoids.
“Our findings indicate that modern NOVA1 is significantly less impacted by lead neurotoxicity,” states Joannes Boyau.
Crucially, when archaic organoids expressed NOVA1 under lead exposure, another gene, Fox P2 exhibited notable differences.
“These genes are linked to cognitive functions, language, and social bonding,” explains Joannes-Boyau. “The diminished neurotoxicity in modern humans compared to Neanderthals could provide a crucial evolutionary advantage.” This suggests that lead exposure has influenced our evolutionary history.
However, Dr. Tanya Smith from Griffith University in Brisbane, Australia, remains cautious about the conclusions drawn by the researchers regarding lead exposure levels or potential evolutionary benefits inferred from their organoid studies.
“This paper is complex and makes speculative claims,” Smith emphasizes. “While it seems logical that ancient humans and wild primates faced some level of lead exposure, the limited scope and variety of fossils studied do not necessarily demonstrate that our ancestors were consistently exposed to lead over two million years.”
Exploring Neanderthals and Ancient Humans in France
Join New Scientist’s Kate Douglas on an engaging exploration of significant Neanderthal and Upper Paleolithic sites across southern France, spanning from Bordeaux to Montpellier.
As dawn broke, a peaceful calm enveloped the city. The shadows along the roads gradually receded, leading us into a radiant morning. It was June, and the few early risers setting up market stalls relished the serene, gentle light, even with the enemy only 50 miles away. Many who had fled the metropolitan area clung to the hope that the defense line would hold after nearly four years. Hope remained alive.
On Houseman Street, a handful of cars headed east, but otherwise, the street was quiet as most residents lingered in wakefulness. However, the inhabitants of the second-floor apartment at No. 102 had been awake for quite some time—indeed, all night. The window shutters remained tightly drawn, as they had been for months. A green bedside lamp glowed in the otherwise darkened room, amidst furniture shrouded in shadows and filled with stramonium steam for asthma, creating a stifling atmosphere. The sounds from the street, coupled with the soundproof cork-lined walls, contributed to a sense of suffocating confinement that visitors undoubtedly felt.
Sitting on a bed in a beautifully adorned Japanese courtyard, propped up by large cushions, he usually lost himself in his manuscript. But today felt different. Overwhelming fear consumed him. One side of his face seemed to sag. When addressing Celeste, his housekeeper, he worried his words lacked clarity, turning his speech into an almost incomprehensible ramble. Convinced he was on the brink of a major stroke—the same fate that plagued both his parents—he found no alternative explanation. It was a hereditary concern. And had his beloved mother, Jeanne, escaped complete frailty? Her stroke had robbed her of language, rendering her unable to communicate with her cherished sons.
In the summer of 1918, as the Germans initiated their final offensives of World War I towards Paris, the renowned novelist Marcel Proust sat on a blue satin chair, engulfed in fear of potential brain damage. Now in his late 40s, he was all too familiar with aphasia; his mother had suffered from it, and his father, Dr. Adrian Proust, had authored an entire book on the subject prior to his own stroke.
Young Marcel had also befriended many of the city’s most distinguished neurologists. At that time, Paris stood as a prominent hub for neurology, with pioneering experts making significant advancements in understanding language disorders following strokes. Without such insights, where would Proust find himself?
On that June morning in 1918, he anticipated a meeting with Joseph Babinsky, a well-known neurologist. Babinsky, unaware of the reasons behind Proust’s visit, simply inquired, “Do you have any symptoms?”
Proust’s intention was to persuade Babinsky to perform a trepanation—drilling holes in his skull—driven by his profound belief that such a drastic step was necessary to halt the looming stroke. However, Babinsky, an expert in his field, reassured Proust that there was no evidence suggesting he was experiencing a stroke and declined to proceed with the operation. It’s difficult to imagine how the trajectory of Proust’s monumental novel would have shifted had he suffered a stroke. While Marcel Proust never experienced a stroke, the shadow of that fear haunted him throughout his life, lingering long after, even when he was near death from pneumonia, it was Babinsky he called upon.
Proust’s anxieties surrounding brain-related illnesses resonate with many. While diseases can afflict anyone in various ways, our deepest fears often lie in disorders that impact our minds. Why is that? Because neurological conditions can transform individuals dramatically. Some may struggle with communication, as Proust feared, while others could experience memory loss, distorted perceptions, or hallucinations. Some might exhibit socially inappropriate behavior, a lack of empathy, or rudeness. Others could become impulsive or withdrawn, developing new addictions or suffering from pathological indifference.
Such behavioral shifts can be distressing and terrifying for both individuals and their loved ones. Yet, they reveal profound insights into our very nature. By examining the consequences of certain brain functions being impaired, we glean understanding about our own normality, how cognitive functions shape our identities—personal and social, formed through our connections with others.
For someone like Marcel Proust, losing the ability to communicate would be devastating. Not only would he lose his gift for writing, but he would also risk dismantling his carefully crafted social presence. The social identity he had labored to cultivate would effectively disintegrate. Proust had invested years nurturing relationships with key figures in French society and possessed remarkable perceptions regarding his connections with influential individuals. As a gay man from a Jewish background, He adeptly navigated the complexities of prejudice and societal expectations in Paris.
Through keen observation and emulation, he became an integral part of the circles he thought he belonged to. Some observers suggested that Proust was a master manipulator, indicating that even while isolated in his dimly lit bedroom, he was unwilling to relinquish control over those around him. However, without language, the intricate web he had worked to weave would no longer be accessible; he would no longer “belong.”
This excerpt is from Massoud Hussain’s workOur Brains, Ourselves(Canong’s publication), recipient of The Royal Society Trivedi Science Book Prize and the latest selection from the New Scientist Book Club. Join us to read together.
The human brain is one of the most intricate entities ever to exist.
Andriy Onofriyenko/Getty Images
Science literature, particularly those authored by scientists, is often perceived as monotonous and challenging. They are sometimes regarded as mere textbooks meant for structured learning. However, the book featuring the finalists for the Royal Society’s Trivite Science Award proves this perception wrong and showcases the judges’ selection for this year: Our Brains, Ourselves by neurologist Masd Hussain.
I was fortunate to serve as a panel chair among six dedicated readers and book enthusiasts, including New Scientist‘s Jacob Aron, who faced the daunting challenge of curating a list of nominees. Our discussions, led by passionate advocates for science, were diverse and engaging, reflecting the love we all share for both literature and science.
We frequently engaged in respectful debates, as I was usually in the company of individuals willing to consider opposing viewpoints. Our varied backgrounds and experiences enriched our understanding of the privileges associated with reading and the act of reading itself.
This year’s submissions featured numerous outstanding scientific works, yet Our Brains, Ourselves notably blended exquisite storytelling with rigorous, cutting-edge science, particularly evidenced in its humanistic approach. Hussain is a neuroscientist and a clinician; seven personal narratives from his patients are highlighted throughout the book.
The experiences shared are diverse. One individual feels an overwhelming apathy post-stroke, while another believes she has a connection with her husband. Each story illustrates profound transformations. This book is a poignant exploration of how neurological disorders can radically alter one’s identity and breed societal alienation.
A recurring theme in the book is the concept of “self” and how our brains shape our identities. It is conveyed empathetically and personally. The scientific elements are firmly grounded in Hussain’s own research, presented in an easily digestible manner, while acknowledging the unknowns. I appreciate this transparency; real science encourages the pursuit of further questions.
While case studies in clinical practices might seem commonplace, the unique personal touch here makes a significant difference. Have you ever felt a disconnect from personal attributes? The narratives of patients with brain disorders provoke thought regarding identity, selfhood, and our social roles.
This notion resonated strongly with our panel. What constitutes belonging? Some individuals encountered in the book are members of immigrant communities, facing prejudice and violence to carve out their place in society. It would seem that as our world becomes increasingly interconnected, our fear of differences should diminish—but this isn’t always the case.
Our Brains, Ourselves encourages readers to reflect on how neurological disorders can profoundly disrupt one’s sense of belonging while illustrating how cognitive function influences one’s identity. Ultimately, our brains substantially define who we are. This compassionate narrative not only educates readers about science but also showcases extraordinary human kindness.
Sandra Knapp is a plant taxonomist at the Museum of Natural History in London and chaired this year’s Royal Society Trivedi Science Book Award judging committee. The winner of the award is Our Brains, Ourselves, the latest addition to the New Scientist Book Club.
Since the inception of brain organoids by Madeline Lancaster in 2013, these structures have become invaluable in global brain research. But what are they really? Are they simply miniaturized brains? Could implanting them into animals yield a super-intelligent mouse? Where do we draw the ethical line? Michael Le Page explored these questions at Lancaster’s lab at the MRC Institute of Molecular Biology in Cambridge, UK.
Michael Le Page: Can you clarify what a brain organoid is? Is it akin to a mini brain?
Madeline Lancaster: Not at all. There are various types of organoids, and they are not miniature brains. We focus on specific parts of the human brain, and our organoids are small and immature. They don’t function like developed human brains with memories. In scale, they’re comparable to insect brains, lacking the necessary tissue present in those brains. I would categorize them closer to insect neural structures.
What motivated you to create your first brain organoid?
I initiated the process using mouse embryonic brain cells, cultivating them in Petri dishes. Some cells didn’t adhere as expected, leading to a fascinating outcome where they interconnected and formed self-organizing cell clusters indicative of early brain tissue development. The same technique was then applied to human embryonic stem cells.
Why is the development of brain organoids considered a significant breakthrough?
The human brain is vital to our identity and remained enigmatic for a long time. Observing a mouse brain doesn’t capture the intricacies of the human brain. Brain organoids have opened a new perspective into this complex system.
Can you provide an example of this research?
One of our initial ventures involved modeling a condition called micropathy, where the brain is undersized. In mice, similar mutations don’t alter brain size. We tested whether we could replicate size reduction in human brain organoids, and we succeeded, enabling further insights into the disease.
Madeline Lancaster in her lab in Cambridge, UK
New Scientist
What has been your most significant takeaway from studying brain organoids?
We are gaining a better understanding of what distinguishes the human brain. I’m fascinated by the finding that human stem cells which generate neurons behave differently from those in mice and chimpanzees. One key difference is that human development is notably slower, allowing for more neurons to be produced as our stem cells proliferate.
Are there practical outcomes from this research?
Much of our foundational biology research has crucial implications for disease treatment. My lab primarily addresses evolutionary questions, particularly genetic variances between humans and chimpanzees. Specific genes that arise are often linked to human disorders, implying that mutations essential for brain development could lead to significant damage.
What types of treatments might emerge from this work in the future?
We’re already utilizing brain organoids for drug screening. I’m especially optimistic about their potential in treating mental health conditions and neurodegenerative diseases, where novel therapies are lacking. Currently, treatments for schizophrenia utilize medications that are five decades old. Brain organoid models could unveil new approaches. In the longer term, organoids might even provide therapeutic options themselves. While not for all brain areas, techniques have already been developed to create organoids of dopaminergic neurons from the substantia nigra, which are lost in Parkinson’s, for potential implantation.
Are human brain organoids already being implanted in animal brains?
Yes, but not for treatment purposes; rather, these practices enhance human organoid research. Organoids usually lack vascularity and other cell types from outside the brain, especially microglia, which serve as the brain’s immune cells. Thus, to examine how these other cells interact with human brain matter, various studies have implanted organoids into mice.
Should we have concerns regarding the implantation of human organoids in animals?
Neurons are designed to connect with one another. So, when a human brain organoid is inserted into a mouse brain, the human cells will bond with mouse neurons. However, they aren’t structured coherently. These mice exhibit diminished cognitive performance after implantation, akin to a brain malfunction; hence, they won’t become super-intelligent.
Images of the color of brain organoids, showing their neural connections
MRC Institute of Molecular Biology
Is cognitive enhancement a possibility?
We’re quite a distance from that. Higher-level concepts relate to how different brain regions interlink, how individual neurons connect, and how collections of neurons communicate. Achieving an organized structure like this could be possible, but challenges like timing persist. While mice have a short lifespan of about two years, human development toward advanced intelligence takes significantly longer. Furthermore, the sheer size of human brains presents challenges; a human-sized brain cannot fit within a mouse. Because of these factors, I don’t foresee such concerns emerging in the near future.
Regarding size, the main limitation is the absence of blood vessels. Organoids start to die off when they exceed a few millimeters. How much headway has been made in addressing this issue?
While we’ve made strides and should acknowledge our accomplishments, generating brain tissue is relatively straightforward as it tends to develop autonomously. Vascularization, however, is complex. Progress is being made with the introduction of vascular cells, but achieving fully functional blood perfusion remains a significant hurdle.
When you reference ‘far away’…
I estimate it could take decades. It may seem simple, given that the body accomplishes this naturally. However, the challenges arise from the body’s integrated functioning. Successfully vascularizing organoids requires interaction with a whole organism; we can’t replicate this on a plate.
If we achieve that, could we potentially create a full-sized brain?
Even if we manage to develop a large, vascularized human brain in a lab, without communication or sensory input, it would lack meaningful function. For instance, if an animal’s eyes are shut during development and opened later, they may appear functional, but the brain can’t interpret visual input, rendering it effectively blind. This principle applies to all senses and interactions with the world. I believe that an organism’s body must have sensory experiences to develop awareness. Certain patients who lose sensory input can end up experiencing lock-in syndrome, an alarming condition. But these are individuals who have previously engaged with the world. A brain that has never engaged lacks context.
As brain organoid technology progresses, how should we define the boundaries of ethical research?
The field closely intersects with our understanding of consciousness, which is complex and difficult to measure. I’m not even certain I have the definitive answer about consciousness for myself. However, we can undoubtedly assess factors relevant to consciousness, like organization, sensory inputs and outputs, maturity, and size. Mice might meet several of these criteria but are generally not recognized to possess human-like consciousness, largely due to their size. Even fully interconnected human organoids won’t achieve human-level consciousness if they remain small. Establishing these kinds of standards offers more practical methods than attempting to directly measure consciousness.
The infant’s brain functions at a distinct rhythm compared to that of adults
Goodles/Aramie
When infants attempt to comprehend their surroundings, their brain activity reveals slower rhythms compared to adults, aiding them in grasping new concepts.
Our brains utilize a network of neurons to interpret sensory input. When a neuron receives a sufficiently strong signal from its neighbor, it transmits that signal to other neurons, generating synchronized waves of electrical activity that alternate between activated and silent states.
These brain waves manifest at various frequencies. A specific brain area may show a greater proportion of neurons synchronized to one frequency over others if it exhibits a range of frequencies simultaneously. For instance, prior research indicates that the adult visual cortex displays a diverse range of frequencies when individuals are observing stimuli, but in higher proportions, more neurons synchronize with the waves at a frequency of 10 hertz.
To determine if the same holds true for infants, Moritz Kester from the University of Regensburg in Germany along with his colleagues enlisted 42 eight-month-olds via their parents. The researchers recorded the infants’ brain activity with electrodes affixed to the scalp, exposing them to dozens of friendly cartoon monsters for about 15 minutes, each monster flashing for two seconds.
The team relied on the fact that brain waves tend to oscillate in sync with rapidly flickering images, enabling them to assess the number of neurons synchronized to various frequencies within the infants’ visual cortex. Each monster was toggled on and off at eight different frequencies ranging from 2 to 30 hertz.
Analysis of the brain activity data revealed that the visual cortex produces waves of synchronized activity in response to the flickering cartoons. However, the most prominent signals emerged at four hertz, indicating greater synchronization with this flicker frequency than with others.
Moreover, this 4-hertz signal was consistently present even when the brain was exposed to flickering at higher frequencies, such as 15 hertz. “What’s particularly intriguing is that regardless of the different frequencies presented, a response at 4 hertz was always observed,” comments Kester.
This rhythm falls within a frequency band known as theta, which is associated with the formation of new concepts, potentially facilitating learning for young children as they observe their environment. “It suggests that infants are in a specific learning mode,” Kester explains.
Researchers supporting this theory further discovered that there were no 4-hertz EEG signals in the visual cortex, nor EEG signals at other frequencies, suggesting a broader neural circuit involvement in other brain areas related to concept formation.
Repeating the experiment with seven adults confirmed prior findings that visual brain circuits are predominantly activated by the 10 hertz frequency, which was also found to persist in the background despite varying speeds of the cartoon flickering.
Further research is necessary to establish whether exposure to 4 hertz flickering images can enhance infants’ capacity to learn new concepts, according to Emily Jones at Birkbeck, University of London. The team is hopeful to gain further insights in an ongoing study, Kester added.
Is it possible to fully comprehend brain function if we can accurately map its structures? Researchers aim to develop a wiring diagram, or connectome, of our neural pathways, yet the task of unveiling the brain’s mysteries is proving to be complex.
The Connectome serves as a roadmap for nerve signal pathways, but Sophie Dovari from Princeton University and her team have found notable gaps in these pathways.
Researchers analyzed the connectome of the nematode worm, Caenorhabditis elegans, and compared it to recorded neural signals. They accomplished this by stimulating each neuron and observing how signals flowed through the connectome. This method is feasible with nematodes due to their relatively simple nervous system, composed of roughly 300 neurons.
Nematode worms are significantly simpler than humans, with approximately 300 neurons depicted in green
Heiti Paves / Alamy Stock Photo
By viewing these two datasets as mathematical networks, researchers can ascertain whether closely connected groups of neurons manifest a high frequency of signal exchanges. They uncovered that this correlation is not always evident.
Dvali notes instances of substantial connection density and overlapping signal exchanges, like how worms eat or the groups of neurons that correspond well. However, even in cases where they appeared significantly connected, a gap remained in understanding their respective functionalities across both networks. Overall, these findings suggest that the biological connectome is insufficient to predict all neural behaviors.
Team member Andrew Leifer, also from Princeton University, points out that signals do not always follow the shortest paths between neurons; some may communicate beyond their direct connections. “While we typically leverage connectomes for research, the multitude of useful connections calls for deeper comprehension,” he explains.
According to Albert Laslo Barabasi at Northeastern University, Massachusetts, criticism surrounding connectomics often revolves around its inability to provide action-oriented insights from structural data. This new paper seeks to address that challenge.
Looking forward, researchers aim to delve deeper into how signals disseminate through the connectome when multiple neurons are activated simultaneously, with aspirations to study more complex organisms, such as fruit fly larvae, recognized for their intricate neural networks. “We are on the verge of a revolution in brain mapping,” Barabasi concludes.
Engaging with information can alter how your brain processes and reacts to it
Tony Anderson/Getty Images
As a passionate reader and writer, I often find myself disheartened. Recent reports indicate a decline in reading for enjoyment among younger generations. When a friend asked if her use of audiobooks provided the same cognitive benefits as traditional reading for her daughter, my initial thought was, “Enjoyment matters more than the format.” However, exploring the science revealed that the medium indeed influences our cognitive process in important and distinct ways.
The Advantages of Reading
Reading unquestionably benefits us. Aside from the knowledge it imparts and the opportunities it opens up, numerous studies link childhood literacy with both physical and mental well-being – and even extended lifespans.
It is believed that reading exercises three crucial cognitive functions. Firstly, it promotes “Deep Reading,” allowing us to connect different sections of text, reflect on their relevance to our lives, and engage with the material critically.
Secondly, reading fosters empathy and bolsters our emotional intelligence—traits that are essential for coping with stress and navigating real-life difficulties. Thirdly, there exists a correlation between reading and cognitive development. The “Theory of Mind” refers to our ability to recognize that others may hold different thoughts and beliefs than we do.
However, discerning the impact of reading from other influences can be challenging. Moreover, readers may enjoy advantages like having leisure time, financial resources, or even genetic traits which can affect overall health, cognition, or longevity.
Nevertheless, a study involving over 3,500 participants attempted to account for these factors, revealing that individuals who read for approximately 30 minutes each day were 20% less likely to pass away in the subsequent 12 years. This benefit was more pronounced among book readers compared to those who primarily read newspapers and magazines.
Digital Media: E-readers and Audiobooks
Comparing print reading to digital formats complicates the research landscape. Some studies suggest that screen reading promotes a more superficial understanding compared to reading printed material.
There are also subtle differences. In a series of experiments conducted by Anne Mangen from Stavanger University, Norway, and Frank Hakemalder from Utrecht University in the Netherlands, it was found that frequent readers of short texts on screens tended to seek meaning less diligently than their paper-reading counterparts. Additionally, increased exposure to screen reading correlated with diminished persistence in tackling longer literary works.
Concerning audiobooks, while the evidence remains limited, I find some solace in the findings. Research indicates that comprehension levels are very similar whether one is reading or listening. However, some nuances exist—meta-analyses of 46 studies discovered that reading provides a slight advantage for interpreting the emotions of characters, among other interpretative skills. Thus, drawing inferences from the text is somewhat more effective when reading.
Listening to an audiobook provides the experience of hearing another person’s voice with its unique intonations, rhythms, and emotions, which can greatly influence interpretation. Janet Gaipel from the University of Exeter notes that contrastingly, reading relies on our inner voice, allowing for a more individualized and self-paced experience. These distinctions may significantly affect how information is perceived and utilized.
Nonetheless, “listening to audiobooks is not somehow detrimental,” Geipel argues. “The real issue lies in how you allocate your attention. Listening can be just as effective as reading if you are fully focused, but multitasking while listening can compromise depth compared to immersive reading without distractions.”
Finding What Works for You
Listening alongside reading introduces yet another layer. A meta-analysis conducted by Virginia Clinton Lisell at the University of North Dakota found that while combining listening with reading might yield slight improvements in understanding, this is likely only true for those who struggle with decoding text, such as individuals with low literacy or those learning to read in a non-native language. For skilled readers, however, this dual engagement may lead to diminished comprehension due to “cognitive load theory,” where presenting information in two formats can create redundancy and overwhelm cognitive resources.
Ultimately, various factors—dyslexia, visual impairments, lengthy commutes, or personal preference—can drive the choice for audiobooks rather than print. As for whether you derive equivalent benefits, “there’s no straightforward answer,” Geipel acknowledges.
If options are available, I suggest reserving an engaging podcast or a thought-provoking book for moments of focus, rather than while preparing dinner. However, if someone is immersed in a story purely for enjoyment, as in the case of my friend’s daughter, choosing an audiobook appears to be a far better alternative than missing out altogether.
Our brain activity and health is influenced by various bodily events
Cavallini James/BSIP/Getty Images
The impact of body fat on our movements, emotions, and even the likelihood of developing Alzheimer’s disease varies based on its location within the body.
While many studies emphasize abdominal fat due to its correlation with cognitive decline and heart disease, few have explored fat distribution in other regions, usually with limited participant numbers.
To broaden understanding, Qiu from the Hong Kong Polytechnic University and her team investigated the effects of fat in the arms, legs, torso, and around internal organs on brain health.
The research team analyzed body composition scans and Brain Imaging data of over 18,000 adults with an average age of 62 involved in the UK Biobank Project. After taking age and other factors into account, they associated excess fat in different body regions with specific brain changes.
For instance, higher fat levels in the arms and torso correlated with thinning in the sensorimotor cortex, which is involved in movement. Increased arm fat was also linked to reduced hippocampal volume, a crucial area for memory that is traditionally affected in Alzheimer’s disease, potentially explaining why arm fat is associated with a higher risk of neurodegenerative disorders.
The researchers found that excess leg fat correlated with diminished connectivity in the brain’s limbic network, which is responsible for emotion and reward processing. This may be due to the fact that fat in the lower body releases leptin, a hormone that regulates hunger, with higher leptin levels connected to reduced limbic connectivity.
Conversely, visceral fat (around internal organs) was the type most strongly linked to functional changes in the brain, uniquely associated with white matter degradation—a characteristic of Alzheimer’s disease—rather than its preservation.
This may arise from the fact that visceral fat produces more inflammatory substances compared to fat located elsewhere in the body, according to Sonia Anand from McMaster University in Canada, which can contribute to brain inflammation.
It remains unclear why arm fat appeared to have both protective and detrimental effects on the brain. “Observing such divergent impacts was intriguing,” noted Mikal Schneider Biary from Rutgers University, New Jersey. This complexity underscores the intricate relationship between body fat and brain health, she added.
The research only established correlations between body fat and brain function, so “we can’t infer any causal connections,” Biary cautions. Some brain changes may indeed influence the distribution of body fat. Moreover, the findings might not apply to the broader population, as there was a notable lack of diversity among participants.
Nevertheless, the study emphasizes that different types and locations of fat exert varying effects, according to Anand. This suggests that treatments focusing on reducing visceral fat could have a more significant impact on brain health than generalized weight loss approaches.
Can scientists transfer animal brains to computers? The answer hinges on how we define “transfer” and “brain.” If we’re a bit flexible in our interpretation, it’s essentially already taking place.
Caenorhabditis elegans are minuscule worms found in soil and decaying plant matter. As multicellular eukaryotes, they technically qualify as animals.
This tiny worm never surpasses 1mm (0.03 inches) in length and is one of the most well-known organisms on Earth.
We have sequenced its genome and mapped all development, encompassing approximately 2,000 cells, including 300 neurons. The variations in this worm are minimal, but what differences do exist have been mapped.
Thus, scientists could model the entire brain on a computer, reproducing not just identical reflex behaviors as found in nature, but even training them to perform new tasks, such as balancing virtual poles (and yes, that’s true).
However, even if we liberally interpret our definitions, this scenario doesn’t entirely hold up.
The C. elegans brain was not uploaded in the conventional sense. Instead, it was replicated using data gathered from years of experiments involving thousands of these worms. There hasn’t been a method to accurately record and transfer the thoughts and memories of an individual creature to a computer.
Caenorhabditis elegans are tiny worms that thrive in soil and decaying vegetation – Image credit: Science Photo Library
Many believe brain uploads represent the future of humanity, viewing it as an “inevitable consequence” of advancements in neuroscience and artificial intelligence (AI), potentially leading to the ultimate solution to death.
Nevertheless, several significant challenges must be addressed before this can become a reality.
As our conscious minds are intricately constructed from the cells and chemicals within our skulls and nervous systems, we must find a way to fully interpret our brain states in exquisite detail.
Next, we need to create a software model that can accurately mimic brain behavior at the molecular, or perhaps even atomic, level.
Over a decade ago, scientists demonstrated that it was feasible to identify neurons and their connectivity in meticulously prepared mouse brains. These brains were stained, sliced to 70 nanometers thick, and then reconstructed into a 3D format using a computer. As expected, the mouse did not survive.
Many believe that brain uploads are the future of humanity – Image credit: Aramie
This serves as an example of a destructive scan. The methods many suggest as necessary for recording a brain in sufficient detail may lead to its destruction.
As medical imaging technology achieves higher resolutions, some speculate that we could one day scan all cell states non-destructively. However, such scans must be instantaneous; otherwise, parts of your brain could be considering new things before the scan finishes.
Could this be achievable with a recently deceased brain? Scientists indicate that it might be essential to scan the brain while it’s actively functioning to ensure all cells accurately model the intended behavior.
Today’s computers are remarkable, yet even the most optimistic futurists predict we may need a century before we can simulate at the atomic scale required.
Moreover, there’s a final profound question. If you can upload your brain non-destructively in 500 years…what happens next? You would exist in a virtual world as computer software, while the original version of you continues to think in your biological form, likely with a slight headache from the scan.
But if you are still alive, did you genuinely trick death? Clearly not. Instead, you’ve allowed for the creation of virtual duplicates that could be used according to their will. That’s a disconcerting thought.
This article answers the question posed by Darcie Walsh from Preston: “Can scientists upload animal brains to a computer?”
We invite you to send us your questionstoQuestion @sciencefocus.com or MessageFacebook,Twitter, orInstagram (don’t forget to include your name and location).
Explore more of our ultimateFun factsand other fascinating science pages.
Do different observers experience similar neural activity in response to the same color? Does color produce distinct response patterns in specific brain areas? To explore these inquiries, researchers at the University of Tübingen utilized existing knowledge of color responses from various observers’ brains to predict the colors an individual is perceiving based on their brain activity. By estimating general brain commonality and responding to achromatic, spatial stimuli, the authors successfully aligned disparate brain responses within a common response framework linked to the retina. In this framework, derived independently of specific color responses, the perceived color can be decoded across individuals, revealing distinct spatial color biases between regions.
Using a sample of male and female volunteers, Michael M. Bannert & Andreas Bartels examined whether spatial color biases are shared among human observers and whether these biases differ among various regions. Image credit: Vat Loai.
Employing functional MRI scans, researchers Michael Banert and Andreas Bartels from the University of Tübingen captured images of subjects’ brains while they viewed visual stimuli, identifying various signals related to red, green, and yellow colors.
Remarkably, the patterns of brain activity appeared similar among subjects who had not participated previously. This suggests that the colors perceived can be accurately predicted by comparing them to the brain images of other participants.
The representation of color in the brain proves to be much more consistent than previously believed.
While it was already feasible to identify the colors an individual observed using functional magnetic resonance imaging (fMRI), this was only applicable to the same brain.
“We aimed to investigate whether similar colors are encoded across different brains,” Dr. Banert stated.
“In other words, if we only have neuronal color signals from another person’s brain, can we predict the colors they’re perceiving?”
“It’s well established that different brains exhibit roughly similar functional structures.”
“For instance, specific areas are more active when viewing faces, bodies, or simply colors.”
During the color experiment, researchers employed specific classification algorithms to analyze fMRI data, systematically differentiating signals originating from the brains of various groups of individuals by color.
Subsequently, data from new subjects were utilized to ascertain the colors they were perceiving using neuronal signals.
To frame each brain’s orientation, scientists spatially mapped how they responded to stimuli at different locations within their visual field using fMRI measurements.
“At this stage, we did not incorporate colors to avoid any bias in our results—only black and white patterns,” Professor Bartels explained.
“By simply merging this mapping data with color information from another person’s brain, we ensured we correctly identified the ‘new’ brain activity related to what the person was observing at that moment.”
“I was surprised to discover that even subtle variations in individual colors show remarkable similarity across brain activity patterns in specific visual processing regions, something previously unknown.”
Spatial color coding in the brain is domain-specific and organized consistently among individuals.
“There must be functional or evolutionary factors contributing to this uniform development, but further clarification is needed,” the authors noted.
The study was published this week in the Journal of Neuroscience.
____
Michael M. Bannert and Andreas Bartels. Large-scale color biases in the functional architecture of the retina are domain-specific and shared throughout the human brain. Journal of Neuroscience Published online on September 8th, 2025. doi: 10.1523/jneurosci.2717-20.2025
New research suggests that artificial sweeteners may have unexpected risks for brain health.
In a study published in Neurology, researchers analyzed the diets of over 12,700 adults in Brazil, revealing that individuals who consumed higher amounts of calorie-free sweeteners experienced a more rapid decline in memory and cognitive abilities over an eight-year period.
This decline was especially notable among diabetic patients and those under the age of 60.
The study examined seven sweeteners commonly found in diet sodas, flavored waters, yogurt, and low-calorie desserts: aspartame, saccharin, acesulfame-K, erythritol, xylitol, sorbitol, and tagatose.
All except tagatose were linked to cognitive decline, particularly affecting memory and verbal fluency.
Participants were categorized into three intake groups. Those with the highest consumption—approximately 191 milligrams daily, similar to a single can of diet soda for aspartame—demonstrated cognitive aging equivalent to 1.6 additional years, at least 62% faster than those with lower consumption.
“Low and no-calorie sweeteners are often regarded as healthier alternatives to sugar, but our findings indicate that certain sweeteners may negatively impact brain health over time,” stated Professor Claudia Kimmy Sumoto from the University of Sao Paulo.
“Prior research linked artificial sweeteners to conditions such as diabetes, cancer, cardiovascular disease, and depression, but the effects on cognition were previously unexplored.”
Consumption of artificial sweeteners similar to daily cans of diet soda was associated with accelerated cognitive decline, akin to 1.6 years of brain aging – Credit: Getty
Interestingly, the link was primarily observed in adults under 60 years old.
“We anticipated that the association would be more pronounced in older adults due to their increased risk of dementia and cognitive decline,” Sumoto noted. “Conversely, our findings suggest that exposure to sweeteners during middle age could be particularly detrimental, which is crucial as this period is vital for establishing long-term brain health.”
The findings do not conclusively prove that sweeteners are the direct cause of cognitive decline, with limitations including reliance on self-reported dietary habits and the absence of control over sweetener usage in the research.
Nevertheless, Sumoto emphasized the need for further investigation, including brain imaging and studies examining gut health and inflammation.
Her team is already conducting neuroimaging studies to better understand these associations, although results are not yet available.
“More research is essential to validate our findings and to explore whether alternative sweeteners like those from the apple family, honey, maple syrup, and coconut sugar provide effective options,” Sumoto concluded.
About our experts
Claudia Sumoto is an assistant professor at the University of Sao Paulo, Brazil. She is a trained physician with research published in journals such as The Lancet, Nature Neuroscience, and Journal of Alzheimer’s Disease.
Dan Berman, International Brain Research Institute
The initial comprehensive activity map of the mammalian brain has unveiled groundbreaking revelations regarding decision-making processes.
For many years, neuroscientists aspired to capture neuronal activity throughout the brain at an individual level. However, challenges persist, including the limitations on the number of neurons an electrode can record, the number of electrodes deployable in a single brain, and the number of animals that a solitary lab can study.
To address these hurdles, a collaboration among 12 laboratories is underway, with each conducting identical experiments and recording duplicates to ensure consistency in collected data. This joint effort, tracking the activity of over 650,000 neurons, has resulted in the first comprehensive brain activity map related to complex behaviors.
“This research exemplifies a novel approach to addressing intricate inquiries in contemporary neuroscience,” stated Benedetto de Martino of University College London, who was not a part of this study. “Similar to CERN, which unites physicists to tackle profound issues in particle physics, this project will bring together global laboratories to confront challenges too expansive for individual teams.”
In each facility, mice were trained to maneuver a small LEGO steering wheel to direct a striped target towards the center of the display. The target was easily distinguishable when the stripes contrasted sharply. As contrast dwindled, the target nearly vanished, compelling the mice to rely on prior knowledge to respond accurately for a reward.
Bias was factored into the experiment, impacting the mice’s expectations about the target’s location. For instance, it could appear on either side of the screen. When the bias was inverted, the mice adjusted their expectations accordingly.
The resulting activity map indicates that decision-related processes are dispersed throughout the brain, rather than localized in one specific area. “Many assertions claimed, ‘this region is responsible for this function.’ However, our findings reveal that decision-making involves numerous regions collaborating through a consensus,” remarked team member Alexandre Pouget from the University of Geneva, Switzerland.
Furthermore, the findings support earlier research indicating that decision-related signals form long before an action is executed. Pouget noted that even prior to the commencement of individual experiments, signals linked to forthcoming decisions are evident. These signals accumulate when the target is presented, prompting the mice to move the wheels until a threshold is reached.
The second study reveals that beliefs regarding the target’s position are encoded very early in the brain’s activity. Researchers discovered that whether the signal emerged from the eye or journeyed to the thalamus, the brain’s relay center, advanced expectations regarding the target’s left or right positioning were already established.
This suggests that from the moment sensory information is processed by our brains, it is inherently influenced by knowledge, altering the conscious decision-making process unconsciously, according to Pouget. “While speculative, this may align with what we interpret as intuition,” he added.
Interestingly, the encoding not only captures recent sensory experiences but also seems to document the recent history of choices made. Lawrence Hunt from Oxford University pointed out, “This indicates that our actions and subjective experiences shape our perceptions, rather than the true objective reality.”
Does this imply our decisions are predestined? “The brain and its environment operate as a deterministic system. People often resist this idea, but it is accurate,” Pouget stated. “This means one can predict, to an extent, what actions will be taken before a decision is made. Nevertheless, when new information arises, expectations must be recalibrated, remaining unaware of how the surrounding world will evolve,” he explained.
Looking ahead, researchers are optimistic that the findings and collaborative methodologies will enhance the understanding of conditions like autism. A mouse model of autism suggests these animals struggle to update previous expectations with new information, according to Pouget, which resonates with our behaviors and perceptions.
In 1964, a San Diego high school student named Randy Gardner participated in a Science Fair Project by staying awake for an astounding 11 days.
By the second day of the experiment, Gardner began to experience memory lapses. By the seventh day, he suffered from intense hallucinations, and by the 11th day, he exhibited inconsistencies, paranoia, and muscular tremors.
Fortunately, the 17-year-old fully recovered without any lasting effects. No one has surpassed this record since then, as noted in the Guinness Record Book. Due to health concerns, sleep deprivation records were discontinued in 1997.
However, cognitive decline can occur without an 11-day deprivation; even a few nights of poor sleep can lead to diminished functioning, memory recall, and emotional regulation.
Now, let’s explore the science behind sleep and its impact on brain performance.
What happens to your brain while you’re sleeping?
Photo credit: Getty
During sleep, our brains engage in essential repairs and various tasks, including removing waste and detoxifying itself.
Short-term memories are organized, long-term memories in the neocortex are solidified, and REM sleep plays a crucial role in problem-solving and emotional regulation.
But it’s not just all activity; there are restorative phases during non-REM sleep stages 1, 2, and 3, which slow the heartbeat, relax the muscles, and reduce brain wave activity—with brief bursts during stage 2.
In REM sleep, brain activity intensifies, resembling the state of wakefulness. The amygdala and hippocampus are highly active, aiding in memory processing and emotion regulation. This dream phase supports creative thinking when you wake up.
Brain impacts of poor sleep
Lack of sleep or poor sleep quality can impact your brain’s performance in several ways.
The prefrontal cortex, responsible for decision-making and problem-solving, becomes less effective. This leads to reduced attention, cognitive flexibility, and working memory.
An overactive amygdala can hinder the emotional contextualization of information, and difficulties in storing information in the cortex weaken memory integration.
Other short-term effects of inadequate sleep include: • Impaired judgment • Slowed reaction times • Declined risk assessment
When sleep deprivation becomes normal
For individuals with chronic sleep disorders, these short-term consequences are part of their everyday reality.
Moreover, chronic sleep deprivation has serious ramifications. Research conducted by the National Medical Library reveals a link between chronic sleep deprivation and Alzheimer’s disease.
“Studies indicate that sleep performs essential housekeeping, such as clearing potentially harmful beta-amyloid proteins,” states the Sleep Foundation.
“In Alzheimer’s disease, the aggregation of beta-amyloid leads to cognitive decline. Even one night of sleep deprivation can increase the accumulation of beta-amyloid in the brain.”
According to one study, individuals with sleep disorders have a significantly elevated risk of developing Alzheimer’s, with an estimated 15% of cases linked to lack of sleep.
Maintaining brain health and cognitive function heavily relies on regular, quality sleep, making it essential to optimize your sleep environment.
Optimizing sleep quality
Hästens, a bed maker based in Sweden, recognizes the vital importance of quality sleep. Since 1852, Hästens has crafted handmade beds in the Swedish town of Kaepi, taking up to 600 hours and using only natural materials.
“A good night’s sleep will enhance your performance,” notes Hästens. “In today’s fast-paced world, sleep may feel like a luxury, but from a medical standpoint, it’s crucial for a strong immune system and overall health.”
Explore the full range of Hästens beds and accessories, and learn more about the benefits of quality sleep here.
Local Hästens Sleep Spa bed tests can be booked online www.hastens.com or at your nearest certified retailer.
As we grow older, our cognitive learning and memory capabilities decline—recent studies have identified the proteins responsible for this phenomenon.
Researchers at UC San Francisco have pinpointed the culprit: an iron-associated protein called FTL1. Its detrimental effects hinder cognitive awareness throughout the aging process, and understanding this may allow us to target it in treating neurodegenerative diseases such as Parkinson’s and Alzheimer’s.
“It’s essentially a reversal of the challenges,” said Saul Vilda, PhD, Associate Director and Senior Author of the Papers at UCSF Bakar Aging Research Institute; Natural aging. “It’s about more than just slowing or preventing symptoms.”
The hippocampus, a brain region essential for learning and memory, is particularly susceptible to the effects of aging. Researchers observed an increase in neuronal FTL1 in the hippocampus of older mice, correlating with cognitive decline and reduced intercellular connections.
The hippocampus, shown here, is vital for the formation of new memories (credit: Getty Images)
In an experiment, scientists artificially increased FTL1 levels in young mice, leading to brain and behavior changes reminiscent of older mice. Elevated FTL1 levels hinder synaptic connections, ultimately resulting in poorer memory performance.
Interestingly, their motor skills and anxiety levels remained stable, indicating that the cognitive impairments were specifically linked to memory and synaptic functions.
When researchers reduced FTL1 levels in the hippocampus of older mice, they noted improved neuronal connections and enhanced performance in memory tests, effectively reversing some signs of aging.
The FTL1 protein is involved in iron storage and metabolism, regulating long-term levels in the brain. As we age, alterations in iron metabolism lead to increased FTL1 in neurons.
By reversing aspects of cognitive aging in mice, this discovery could pave the way for treatments that counteract the effects of FTL1 in the brain, potentially restoring cognitive function in older adults.
“Identifying elements that seem to promote aging while keeping your brain youthful is crucial for overall health and activity as you age. FTL1 appears to be an anti-aging champion,” stated Andrew Steel in BBC Science Focus.
“This is an intriguing preliminary study, but as this research was conducted on mice, we must observe whether the same effects occur in humans.”
Psilocybin, the hallucinogen, is derived from numerous magical mushrooms
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A single dose of the psychedelic compound psilocybin may suffice to alter the connections within specific brain networks.
Psychedelic substances like psilocybin, sourced from various magical mushrooms, impact individuals’ perceptions of time, space, and self. Furthermore, they exhibit potential in addressing mental health issues such as depression and anxiety, largely due to their capability to enhance brain plasticity—though the mechanisms remain unclear.
Currently, Alex Kwan, from Cornell University in Ithaca, NY, and his team conducted experiments where mice received injections of either psilocybin or saline. The following day, they injected a genetically modified rabies virus, known for crossing synaptic gaps and indicating neuron connections.
Scans and dissections helped visualize the virus’s effects throughout the brain, revealing new neuronal connections. This research demonstrated that mice treated with psilocybin fortified the links between the brain’s resfluniur cortex—which integrates imagination, memory, and sensory data—and areas of the prefrontal cortex tied to planning and social behavior, in comparison to those receiving saline solutions.
Moreover, psilocybin seems to reduce connections involved in the cortical recurrent loops, which, while valuable for holding onto important memories, can, in some mental health conditions, perpetuate negative thoughts and behaviors. It is theorized that disrupting these loops is vital in addressing various mental health conditions.
“I believe this is the next phase we need to clarify,” stated Michael Wheeler from Brigham and Women’s Hospital in Boston. “Understanding these circuits that connect associative regions could be pivotal to unlocking mechanisms.”
“The modifications brought about by psilocybin treatment play a significant role in its effects on mood disorders,” said Eero Castén from the University of Helsinki, Finland. He added, however, that psilocybin merely offers a chance for remodeling; the actual circuits that strengthen or weaken may depend on the animal’s actions.
This line of research suggests that in the future, one might be able to select which brain connections to alter based on the mental health condition being treated. “Our findings present an exciting pathway for future work that combines neuroregulation with psychedelics to precisely target specific neuroplastic circuits,” the researchers noted in their publication.
Psilocybin use illustrates the “set and setting” phenomenon linked with psychedelic substances, exploring how various activities and environments influence brain alterations. The user’s mindset and surroundings can significantly impact drug effectiveness, resulting in “good” or “bad” trips.
Although this study was conducted on mice, it remains uncertain if the same connectivity changes occur in humans after consuming psilocybin. Nevertheless, Wheeler suggests the mechanisms might be comparable. This mouse study parallels findings in human brain scan research from 2024, which indicates that psilocybin may enhance connectivity in specific brain areas.
Deep brain stimulation is already utilized for Parkinson’s disease
Living Art Enterprise/Science Photo Library
Brain implants capable of detecting pain and responding with deep brain stimulation may provide relief for individuals suffering from previously untreated chronic pain.
Deep brain stimulation (DBS) involves using tiny electrodes to stimulate the brain, showing potential but also yielding inconsistent outcomes. The conventional method has typically applied a one-size-fits-all targeting of brain regions, despite indications that pain can stem from varying circuits in different individuals.
Thus, Prasad Shirvalkar and his team at the University of California, San Francisco, explored whether a personalized system might yield better results. In their study, six individuals with previously untreated chronic pain had their intracranial brain activity recorded and stimulated across 14 locations in the brain for ten days.
Out of five participants, the researchers pinpointed specific sites and stimulus frequencies that resulted in the most significant pain relief. While one participant noted no substantial relief, he could hold his wife for the first time in years, a notable improvement in his physical capabilities.
The research team employed machine learning to analyze and differentiate the electrical patterns associated with high and low pain levels. Consequently, they implanted permanent DBS electrodes personalized for each participant to monitor brain activity and optimize stimulation for pain detection and deactivation during sleep.
After six months of adjustments, each device underwent a trial where participants experienced real personalized stimulation for three months, followed by fake stimulation for another three months, or vice versa. The false stimulation targeted non-ideal locations with very low frequencies, and pain metrics were monitored multiple times daily throughout the trial.
On average, authentic stimulation led to a 50% reduction in daily pain intensity compared to the increase observed with spurious stimulation. Notably, the daily step counts increased by 18% during the false stimulation phase. Participants also reported fewer depressive symptoms and less pain interfering with daily life when undergoing real stimulation. These improvements persisted for over 3.5 years post-trial.
“This significant study employs the latest tools,” remarks Tim Dennison from Oxford University.
A previous challenge with DBS technology involved habituation; the brain would adapt to continuous stimulation, diminishing its effectiveness. Dennison suggests that extended benefits may arise from stimulating participants only when pain levels are elevated. The next phase will involve comparing adaptive versus constant stimuli to evaluate differences in outcomes.
“The other major hurdle lies in the economic feasibility and scalability of this method,” Dennison notes.
As we age, it’s common to perceive others as more content, as revealed by a recent study.
Researchers have discovered that older adults often exhibit a “positive bias” in interpreting facial expressions. This suggests they are more inclined to classify neutral or negative faces as happy rather than sad or angry.
“This indicates they tend to interpret vague or ambiguous expressions as ‘happy’ instead of ‘sad’ or ‘angry,'” noted Dr. Noham Wolpe in an interview with BBC Science Focus. “Crucially, this bias correlates with subtle cognitive decline and alterations in the specific brain circuits responsible for emotional processing and decision-making.”
Using data from over 600 adults, the research team examined this phenomenon through emotion recognition tasks along with brain imaging techniques.
They found structural variations in the hippocampus and amygdala—key regions for memory and emotion—and changes in connectivity with the orbitofrontal cortex, which plays a role in weighing emotional information and guiding decisions.
“These regions form crucial networks that aid in interpreting emotional signals and informing decisions,” Wolpe explained, highlighting how the relationship between the orbitofrontal cortex and amygdala strengthens in adults facing cognitive decline.
“This enhancement may lead them to perceive ambiguous or neutral emotional signals as positive, a phenomenon known as positive bias,” he remarked, noting that the reason behind this increased connectivity associated with cognitive decline is still unknown.
Researchers remain uncertain why the interamygdala connectivity and orbitofrontal cortex, highlighted in red, strengthen in individuals with cognitive decline – Trust: Getty
Although this research is in its nascent stages, its implications are significant. Positive biases might one day serve as early indicators of dementia, as changes in emotional processing frequently precede memory impairment.
“While emotion recognition tests are not yet ready to replace current cognitive assessments, in the future they could be combined with standard screening methods to enhance early detection,” Wolpe stated.
Wolpe and his team are already investigating innovative approaches, such as immersive virtual reality tasks, to better understand how people instinctively respond to emotional signals.
The next objective is to determine if this positive bias can actually forecast cognitive decline. The team has recently concluded a follow-up evaluation of participants in the Cambridge Aging and Neuroscience Research, approximately 12 years after the original assessments. Participant data is also being linked to GP records to monitor dementia diagnoses.
“A crucial takeaway,” Wolpe mentioned, “is that subtle biases in how we perceive others’ expressions can signal early brain changes, long before the typical signs of dementia manifest.”
“Grasping these connections could pave the way for quicker detection and ultimately more effective interventions.”
read more:
About our experts
Noham Wolpe is a senior lecturer at the Sagol School of Neuroscience at Tel Aviv University. His research focuses on understanding the interplay between cognition, mental health, and behavior, both in health and disease.
Healthcare has witnessed remarkable advancements over the past few decades. In high-income nations, the survival rate for certain types of pediatric leukemia has increased from about 10% to over 90%. HPV vaccinations have decreased the incidence of cervical cancer, and early detection of HIV can lead to life expectancies similar to that of the general population.
In contrast, progress in mental health treatment has been less pronounced. Psychiatry often struggles with a perception of stagnation in treatment methodologies. Historically, it has heavily relied on psychopharmaceuticals developed in the mid-20th century. The field has remained largely anchored to these early drug treatments.
This stagnation is not due to a lack of effort. In the 1970s, molecular psychiatry emerged, focusing on the molecular basis of mental health conditions through proteins, genes, and signaling pathways. The goal was to anchor diagnostics and treatments to biological mechanisms instead of merely interpreting subjective symptoms. Despite advances in genetic research, including exploring the genetic links to schizophrenia, we have yet to see significant improvements in mental health treatment paralleling those in physical health.
The new approach is targeting chronic inflammation.
Given that approximately 8-16% of individuals in high-income countries like England experience anxiety and depression, a fresh perspective is crucial. Current innovative approaches focus on chronic inflammation, a phenomenon linked not just to heart disease and type 2 diabetes, but also to mental health.
For many, chronic low-grade inflammation results from the pace of modern life, often fueled by factors such as stress, obesity, and poor dietary choices. Promising developments suggest that certain anti-inflammatory medications may have potential benefits for the brain, alleviating issues associated with depression and dementia (“Chronic inflammation harms your mind. Here’s how to calm it down”).
These findings also clarify that managing mental health can be approached through actions such as regular exercise, relaxation techniques, and nutritious eating.
While this path may not work for everyone, given that antidepressants fail to help approximately 30% of those treated for depression, any progress is welcomed.
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