Interview with Hannah Ritchie: “Environmental Anxiety Isn’t Very Productive”

With constant headlines about floods, bushfires, and record temperatures, it’s surprising how many people think our current generation will be in even worse trouble than when we inherited the planet. Not. But is that belief true? hannah richie I do not think so. She is cautiously optimistic that we may be the first generation to inherit the environment in better shape than it was back then.

She came to this counterintuitive conclusion after a decade of digging into the environmental record as a data scientist at the University of Oxford and principal researcher at the influential online publication Our World in Data.in her new book it’s not the end of the world, Ritchie lays out graphs that show the positive steps we’ve already taken to change our behavior and mitigate climate change, from reducing coal usage to reducing carbon emissions. I am.she speaks new scientist She talks about her growing confidence that we can solve the world’s environmental problems and lists some key trends that give us hope that we can turn things around.

Alison George: I’m talking about that day. report We’ve seen a dramatic increase in online searches related to “environmental anxiety.” Still, you study long-term environmental trends and are reasonably optimistic.

Hannah Ritchie: There’s still some anxiety and worry, but I think there’s now a sense of optimism that things can change. That fear is completely valid, and I can understand why people feel that way. I feel it. However, that feeling alone is not very helpful. You need to combine your senses…

Source: www.newscientist.com

Improving the Understanding and Management of AI

evil robot artificial intelligence

A new paper discusses the complex role of AI in society and highlights its potential for both benefit and harm. He explores AI’s contribution to national security, its role in exacerbating social problems such as radicalization and polarization, and the importance of understanding and managing its risks.
Credit: SciTechDaily.com

Artificial intelligence (AI) and algorithms have and are being used to exacerbate radicalization, strengthen polarization and spread racism and political instability, according to academics at Lancaster University. .

Jo Barton, professor of international security at Lancaster University, argues that AI and algorithms are not just tools used by national security agencies to thwart malicious online activity. He suggests that they can foster polarization, radicalism and political violence, thereby posing a threat to national security itself.

In addition to this, he says the securitization process – which presents technology as an existential threat – has helped shape how AI is designed, how it is used, and the harmful outcomes it produces.

AI in securitization and its social impact

Professor Barton’s paper was recently published in Elsevier’s High Impact magazine. Technology in society journal.

“AI is often framed as a tool to counter violent extremism,” Professor Barton says. “This is the other side of the argument.”

This paper examines how AI has been securitized throughout its history and in media and popular culture depictions, creating polarizing and radicalizing ideas that have contributed to political violence. We explore this by examining contemporary examples of AI that have had an impact.

AI in War and Cybersecurity

This article explores how the classic film series The Terminator, which depicts a holocaust caused by an “advanced and malignant” artificial intelligence, has changed the public’s perception of artificial intelligence and how machine consciousness could have catastrophic consequences for humanity. He cites it as being more helpful than anything else in instilling fear. Humanity – In this case nuclear war and a deliberate attempt to wipe out humanity. seed.

“This distrust of machines, the fear associated with them, and their association with biological, nuclear, and genetic threats to humanity has led to a desire on the part of governments and national security agencies to influence the development of technology. connected, we can reduce risks and (in some cases) exploit its positive potential,” writes Professor Barton.

Professor Barton said advanced drone roles, such as those used in the Ukraine war, were now capable of full autonomy, including functions such as target identification and recognition.

There have been widespread and influential campaign discussions, including at the United Nations, to ban “killer robots” and ensure that humans are always informed about life-or-death decisions. According to him, the infiltration of armed drones continues to advance rapidly.

In cyber security (computer and computer network security), AI is used in major ways, the most prevalent areas being (dis)information and online psychological warfare.

The Putin regime’s actions against the 2016 US election process and the subsequent Cambridge Analytica scandal showed that AI combined with big data (including social media) polarizes, encourages extremist beliefs, and manipulates identities. It showed the possibility of producing political effects centered on group. This demonstrated the power and potential of AI to divide society.

The social impact of AI during the pandemic

And during the pandemic, AI was seen as a positive in tracking and tracing. virus But it also led to privacy and human rights concerns.

This article examines AI technology itself, arguing that problems exist in the design of AI, the data it relies on, how it is used, and its outcomes and impacts.

The paper concludes with a strong message for researchers in cybersecurity and international relations.

“AI certainly has the ability to transform society in positive ways, but it also poses risks that need to be better understood and managed,” said John C., an expert on cyber conflict and emerging technologies and a university professor. Professor Barton, who is part of the Security and Protection Science Initiative, writes:

“It is clear that understanding the dichotomous impact of technology is critical at every stage of its development and use.

“Cybersecurity and international relations scholars have an opportunity to incorporate these elements into new AI research agendas and avoid treating AI as a politically neutral technology.

“In other words, concerns about the security of AI systems and their societal impact should not be overridden by how they are used in international and geopolitical struggles.”

Reference: “Algorithmic extremism? The Securitization of Artificial Intelligence (AI) and its Impact on Radicalism, Polarization, and Political Violence,” by Joe Barton, September 14, 2023. Technology in society.
DOI: 10.1016/j.techsoc.2023.102262

Source: scitechdaily.com

Probiotics found effective in reducing fatigue and memory loss related to prolonged COVID-19 infection

Probiotics, illustration of live microorganisms that can affect intestinal bacteria

ART-ur/Shutterstock

A daily cocktail of prebiotics and probiotics can help reduce fatigue, memory, and symptoms in people with long-term COVID-19 (symptoms that persist for months or years after being infected with COVID-19). May be useful in treating gastrointestinal complaints.

Although little is understood about long-term coronavirus infections, previous research has shown that people with the disease have lower levels of certain gut microbes than those without. Masu. In particular, they lack gut bacteria that produce compounds called short-chain fatty acids that regulate immune responses.

Siu Ng and his colleagues at the Chinese University of Hong Kong have formulated a mixture that boosts the production of short-chain fatty acids. The product, called SIM01, contained three probiotics (live bacterial strains) and three prebiotics (compounds that help the growth of beneficial gut bacteria).

They distributed this cocktail to 232 adults. Another group of 231 adults took a mixture containing starch and low-dose vitamin C. Both mixtures were taken twice a day for 6 months. All participants were residents of Hong Kong, had previously tested positive for COVID-19, and met the U.S. Centers for Disease Control and Prevention’s criteria for long-term COVID-19 infection.

Researchers used a questionnaire to assess 14 long-term COVID-19 symptoms in participants before treatment began and after treatment ended. At the end of the trial, people who received SIM01 were likely to experience relief from five long-term coronavirus symptoms: fatigue, memory loss, difficulty concentrating, general unwellness, and gastrointestinal upset. It was found to be about 2 to 2.5 times higher on average. The research team also found no serious side effects from the treatment.

Analysis of fecal samples taken before and after the trial revealed that SIM01 increases gut microbial diversity and promotes the growth of beneficial gut bacteria, Ng said. Therefore, she says, it could be useful in treating other conditions that are associated with disruption of the gut microbiome, such as chronic fatigue syndrome.

However, it is unclear how these changes in the gut reduce the symptoms of long-term coronavirus infection. timothy sampson At Emory University in Georgia. “It makes sense that the microbiome has the ability to mediate immune responses, but… [immune system] What is actually at the root of [long covid] You get symptoms,” he says.

topic:

Source: www.newscientist.com

SLIM lunar lander from Japan successfully enters lunar orbit

Smart Lander for Investigating Moon (SLIM) aims to demonstrate pinpoint landing technology and obstacle detection technology to “land where you want to land.” Credit: JAXA

Japan Aerospace Exploration Agency(JAXA) announced that its Smart Lander for Lunar Exploration (SLIM) has successfully entered lunar orbit at 16:51 on December 25, 2023 (Japan Standard Time, JST).

SLIM’s lunar orbit will be inserted into an elliptical lunar orbit connecting the moon’s north and south poles every 6.4 hours, and the altitude at the point closest to the moon (near orbit) will be approximately 600 km (approximately 370 miles). . , 4,000 km (about 2,500 miles) at its furthest point from the moon (Apolune). The orbit change proceeded as planned, and the spacecraft is currently in a normal state.

Lunar orbit insertion (LOI) on December 25, 2023 at 16:51 (Japan time).
Light blue line: current orbit of the moon.
Future Plans:
Green line: Circular orbit at an altitude of approximately 600km.
Yellow line: Altitude approximately 600km x 150km on an elliptical orbit.
Red line: Altitude approximately 600km x 15km on an elliptical orbit. Credit: JAXA

From now on, the Apollone point will descend until mid-January 2024, and the orbit will be adjusted to a circular orbit at an altitude of about 600 km. After that, the perigee will drop and preparations for landing will begin. On January 19th, the near-orbit point will be lowered to an altitude of 15 km (approximately 9 miles), and the descent toward the moon will begin at around midnight (Japan time) on January 20th, with a scheduled landing on the lunar surface. There is. Around 0:20 a.m. on January 20th (Japan time)

Source: scitechdaily.com

Common household products and cosmetics found to impact cell epigenetics

New research has found that formaldehyde poses serious risks to epigenetics, interfering with gene activity and potentially causing cancer and other diseases. The study emphasizes the need for stricter policies to limit exposure to formaldehyde, given its prevalence in various household products, cosmetics, polluted air, architecture, and other industries.

The research, conducted by Dr. Manel Esteller and Dr. Lucas Pontel from the Josep Carreras Leukemia Research Institute and Dr. Christopher J. Chan from the University of California, Berkeley, focused on the effects of high formaldehyde concentrations in the body. The study revealed formaldehyde’s harmful impact on normal epigenetic patterns and its association with cancer, liver degeneration, and increased asthma risk.

Formaldehyde is commonly found in products used in architecture, furniture manufacturing, textiles, and hair products, as well as in polluted gases and the metabolism of certain food substances. It can also be produced in the body and has the potential to alter the epigenetic landscape of cells.

The study concluded that formaldehyde inhibits the production of S-adenosyl-L-methionine (SAM), a universal donor of the methyl chemical group that regulates genetic activity. This decrease in SAM content leads to a loss of methylation of histones, proteins that package DNA and control gene function, contributing to formaldehyde’s carcinogenic properties.

As such, the researchers stressed the need for environmental and health policies aimed at reducing exposure to formaldehyde in various industries and environmental sources. Despite restrictions by international health authorities, there are still areas of work where formaldehyde is used at high levels, necessitating further regulations to minimize exposure to this hazardous substance.

Reference: Vanha N. Pham, Kevin J. Bruemmer, Joel DW Toh, Eva J. Ge, Logan Tenney, Carl C. Ward, Felix A Dingler, Christopher L. Millington, Carlos A. Garcia Prieto, Mia C. Pross Holmes, Nicholas T. Ingoglia, Lucas B. Pontel, Manel Esther, Keetan J. Patel, and Daniel K.・Nomura, Christopher J. Chan, November 3, 2023, science. DOI: 10.1126/science.abp9201

Source: scitechdaily.com

Hubble’s Close-Up of UGC 8091

The Hubble team has released a close-up image of UGC 8091, a dwarf irregular galaxy that resembles a glittering festive snow globe.



This Hubble image shows UGC 8091, a dwarf irregular galaxy about 7 million light-years away in the constellation Virgo. The color images were created from separate exposures taken with Hubble’s Advanced Survey Camera (ACS) and Wide Field Camera 3 (WFC3). Image credits: NASA / ESA / Hubble / Yumi Choi, NSF’s NOIRLab / Caroline Gilbert, STScI / Julien Dalcanton, Center for Computational Astrophysics and University of Washington Flatiron Institute.

UGC 8091 It is located in the constellation Virgo, about 7 million light years away from Earth.

Also known as GR 8, DDO 155, LEDA 44491, or TC 257, this galaxy discovered It was discovered by astronomers at Lick Observatory in the 1940s and 1950s.

“Unlike other galaxies whose stars appear more regular, UGC 8091 is classified as an irregular galaxy,” said the Hubble astronomer.

“It’s not hard to see why. The stars that make up this cluster look more like a tangle of bright string lights than a galaxy.”

“While some irregular galaxies are thought to have become entangled due to intense internal activity, others are known to have formed through interactions with neighboring galaxies.”

“The result is a class of galaxies with a wide range of sizes and shapes, including these galaxies with diffuse and scattered stars.”

UGC 8091, also classified as a dwarf irregular galaxy, contains about 1 billion stars.

“That’s a huge amount of light, but not for a galaxy. Our Milky Way galaxy is thought to contain more than 100 billion stars, and other galaxies have trillions. “There could be as many stars as possible,” the astronomers said.

“Dwarf galaxies often orbit around larger galaxies, and their lower masses make them vulnerable to interference and consumption from larger neighbors, and in the process they destroy twisted dwarfs like UGC 8091. A galaxy is generated.”

“This type of galaxy is thought to have characteristics similar to the very old and distant galaxies seen in deep-field images.”

“Investigating the composition of dwarf galaxies and their stars, particularly their low metal content, could help uncover evolutionary links between these ancient galaxies and more modern galaxies like ours. We hope it will be helpful.”

To do this, researchers have carefully examined UGC 8091’s colorful stars.

“By using filters that restrict the light entering Hubble’s instruments to very specific wavelength ranges, we can pick out different features of galaxies,” the researchers said.

“These filtered images can be recombined to create a full-color image. An astonishing 12 filters are combined to produce this image, capturing light from the mid-UV to the red end of the visible spectrum. Contributing.”

“The blooming red spots represent light emitted by excited hydrogen molecules in hot, energetic stars formed in recent starbursts.”

“The other sparks in this image are a mixture of older stars.”

Source: www.sci.news

Climate’s Effect on Migration Patterns in Africa

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Homo Erectus

This skull belonged to Homo erectus, the first human species to leave Africa about 2.1 million years ago. When Homo erectus migrated from Africa, the climate in the northeast of the continent was wetter and more lush than it is today, according to a new study. Climate cycles combined to form green corridors, which our early ancestors likely took advantage of during migration. Credit: Mizmareck / FlickrThe green corridor that runs through the Sahara desert emerged just as our ancestors migrated from Africa. This is shown by the following new research. Aarhus University.About 6 million years ago, something amazing happened in the deep forests of eastern Africa. Chimpanzees, our closest relatives in the animal kingdom, evolved in one direction, while our first ancestors continued to evolve in another direction.Over the next millions of years, the differences between early humans and chimpanzees grew larger and larger. Our ancestors climbed down from trees and began walking upright on two legs, freeing their hands to use tools.This was the beginning of a development that would end with humanity conquering most of the Earth.About 2.1 million years ago, the first humans, Homo erectus, migrated from Africa. The journey took them through northeastern Africa and the Middle East (areas today mostly covered in desert), and on to Europe and Asia.Black dots in the Mediterranean indicate where sediment cores were collected. This area is supplied with terrestrial material from northeastern Africa, but the landscape and vegetation changed under the influence of the African Wet Period.Credit: Nature Communications Earth and EnvironmentFor years, researchers have speculated about how Homo erectus was able to traverse the arid, unforgiving desert with no food, water or shade.New research from Aarhus University suggests Homo erectus may not have been walking through deserts when it left Africa, says Rachel Lupien, one of the researchers who contributed to the new results. explain.“We know that there are repeated periods of changing climate in the Sahara Desert. We call this phenomenon the “Green Sahara” or the “African Wet Period.” During the green season, the desert shrinks significantly, transforming into a landscape resembling the East African savanna we know today,” she says, adding:”Our results show that the Sahara was greener at the very time Homo erectus first migrated than at any time in the 4.5 million years we studied. most likely could have walked through the green corridor outside.”the race that conquered the worldThe first humans were seed Homo erectus appeared in eastern Africa more than 2 million years ago.Homo erectus was the first hominin to learn how to carve an ax out of stone. These axes were probably used as weapons for killing prey and cutting meat from bones. They were probably also the first to learn how to control fire.Homo erectus was slightly shorter than modern humans, but more muscular. They had wider hips and elongated skulls. Additionally, their brains were significantly smaller, about half the size of ours.For more than 1.5 million years, Homo erectus lived and spread throughout most of the planet. From Africa, through Europe and Asia, across the Strait of Malacca to some islands in Indonesia. This made Homo erectus the longest-lived human species. We, Homo sapiens, evolved about 300,000 years ago.sauce: natural history museumThe ocean floor reveals past climateThe Sahara Desert as we know it today is in one of its dry seasons. The duration of these periods varies, but approximately every 20,000 years, the continent goes through both wet and dry cycles. These rainy seasons are what Rachel Lupyan has called “Africa’s wet seasons.””How wet it gets during the wet green period varies. In fact, there are two other cycles involved, one lasting 100,000 years and one lasting 400,000 years. So , over a period of 100,000 years, the wet period will vary, becoming wetter or drier than usual. The same is true for 400,000-year intervals,” says Rachel Lupyan.But how do we actually know what Africa’s climate was like hundreds of thousands of years ago?The ocean floor tells us, and for this very reason, we actually already know a lot about past climates, she explains.”Using core samples from the Mediterranean Sea, we can learn what the climate was like millions of years ago. Layers of sediment have formed on the ocean floor, and these layers contain Small molecules can tell us a great deal about what the climate was like in the past.”Substances that make leaves shineOver time, material ejected from North Africa forms a new layer on the ocean floor that slowly descends across the ocean. Therefore, the buried ocean floor acts as a kind of logbook that can tell us what the climate was like in the past.The layer has a set of biomarkers that store information about past climate. One of these markers is a set of molecules that plants use to protect their leaves. They are also called leaf wax, explains Rachel Lupyan.”Waxes coat trees, bushes, and blades of grass, making them shine. When a plant dies, most parts of the plant decompose rapidly, but wax molecules can survive for long periods of time. That is why such molecules are often found in sediments that are millions of years old.”The chemical composition of wax molecules can tell us what the climate was like when that layer formed. For example, the hydrogen molecules in the wax can give some information about how much precipitation there was.“Water contains hydrogen, so hydrogen can be used to circulate water. Water on Earth contains both regular hydrogen and deuterium (deuterium). “When it rains a lot, plants can absorb relatively less deuterium, but when it’s dry they absorb more,” she says.Carbon holds important knowledgeRachel Lupyan and her colleagues could tell by the amount of deuterium in the wax of leaves during wet and dry times. But hydrogen doesn’t tell us anything about which plants grew in humid climates.But it is present in the carbon atoms found in leaf wax, she explains.“There are two main types of plants. We also refer to them as C3 and C4 plants,” she says.”About 90 percent of all plants are C3 plants. They live in most areas of the earth, except in extremely dry or very hot regions. C4 plants, on the other hand, They specialize in surviving in areas with high temperatures.”C3 and C4 plants produce leaf wax containing different amounts of heavy carbon, allowing researchers to distinguish between them in samples. In this way, you can “read” which types of plants were most dominant at the time.”At the time Homo erectus migrated out of Africa, more C3 was detected in samples than during any other humid period in the past 4.5 million years. It shows a change to grassland or savannah,” she says.3 types of photosynthesisBroadly speaking, there are three different methods in the plant kingdom. photosynthesis. There is a C3 plant, a C4 plant, and his third variant called the CAM plant.90% of all plants are C3 plants, 6% are CAM plants, and only 3-4% are C4 plants. However, this is not the case in Africa. In Africa, vast grasslands have a much higher proportion of C4 plants.Differences among plants are due to different coping strategies when moisture in the air or soil is limited.When it gets too dry, C3 plants close the small stomata in their leaves and absorb CO2. When the hole closes, the plant can no longer photosynthesize and begins burning stored carbon, expelling water and carbon dioxide. If this continues for too long, the plant will die.On the other hand, C4 plants can photosynthesize even in dry conditions. Even though the stomata are closed, they continue to convert CO2 into energy. They can do this with the help of a molecule with four carbon atoms, which gives the plant species its name. CAM plants use his third method and can cope even with drier regions.Wheat, oats, rice, and sunflowers are examples of C3 plants. His known C4 plants are corn, sugar cane, and amaranth, while succulents, cacti, and pineapple are his CAM plants.sauce: khan academy, biology dictionary and rex.dkGreenest 2.1 million years agoGreen periods in Africa, similar to ice ages in northern latitudes, are caused by small fluctuations in the Earth’s orbit around the sun. Geologists call these fluctuations Milankovitch cycles.And two of these changes in particular will play an important role as the Sahara desert receives more rainfall, explains Rachel Lupyan.”The Earth wobbles a bit in its orbit around the sun.…



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Source: scitechdaily.com

The Relationship Between Seismology and Climate Change Noise

Since the 1980s, seismic observatories have detected increases in the strength of ocean waves that correlate with climate change. A Colorado State University study analyzed more than 35 years of data and found that ocean waves are becoming significantly stronger, reflecting the increased intensity of storms due to global warming. This seismic data reveals long-term trends and changes in wave energy and highlights the need for resilient strategies to protect coastal regions from the effects of climate change.

Since the late 1980s, modern digital seismic observatories have been monitoring Earth’s vibrations around the world. Previously thought by seismologists to be just a background disturbance, the persistent low hum produced by ocean waves has become stronger since the late 20th century, according to a study led by Colorado State University.

This research nature communicationsexamines data from 52 seismic stations that recorded the Earth’s movement once a second over 35 years. This decades-long record supports independent climate and ocean research that suggests storms are becoming more intense as the climate warms.

“Seismology can provide stable, quantitative measurements of what is happening to waves in the world’s oceans, complementing research using satellites, oceanography, and other methods.” said author Rick Astor, professor of geophysics and chair of Earth Sciences at CSU. “The seismic signal is consistent with these other studies and shows the types of features expected from anthropogenic climate change.”

Astor and his collaborators at the U.S. Geological Survey and Harvard University studied first-order microseisms, the seismic signals produced by large, long-period waves that cross shallow regions of the world’s oceans. The ocean floor in coastal areas is constantly being pushed and pulled by these waves, and these pressure changes generate seismic waves that are picked up by seismometers.

Seismic station locations and global trends since the late 1980s: (a) Ground vertical acceleration amplitude in billionths of a meter, (b) Acceleration amplitude normalized to the historical median, and ( c) Normalized by the historical median of seismic energy.Credit: Rick Astor

Seismometers are best known for monitoring and studying earthquakes, but they also detect many other things, including the movement of glaciers, landslides, volcanic eruptions, large meteorites, and noise from cities. Seismic waves from various forces on or within the Earth’s surface can be seen at great distances, sometimes even on the other side of the Earth.

“As the atmosphere and ocean warm, storms become more intense because they contain more energy, and the ocean waves they cause increase in size and energy,” Aster said. “Increasing the energy of ocean waves directly increases the strength of seismic waves.”

make (bigger) waves

Seismic signals show that the Southern Ocean waves of the infamous storm around Antarctica are predictably the most intense on Earth, while the waves in the North Atlantic are the most rapidly intensifying in recent decades, with waves in eastern North America and western Europe It reflects the storm that rages between.

In addition to the steady rise in wave energy that reflects widespread increases in global ocean and air temperatures, the data also show multi-year climate patterns such as El Niño and La Niña that influence the strength and distribution of global storms. Masu. And an even bigger storm.

“It’s clear that these long-term earthquake records show general signs of storm activity around the world, in addition to long-term intensification due to global warming,” Astor said. “It looks like a small signal from year to year, but it’s gradual and becomes very clear when you work with more than 30 years of data.”

Astor and his colleagues found that global average ocean wave energy has increased by a median of 0.27% per year since the late 20th century, and by 0.35% per year since January 2000.

Stormy weather forecast

Mr Astor said storm surges associated with larger waves and larger storms, coupled with rising sea levels, were a serious global problem for coastal ecosystems, cities and infrastructure.

“In addition to efforts to mitigate climate change itself, we will need to implement resilient strategies to ensure coastal populations and ecosystems are protected from an increasingly stormy future.” said Astor.

Reference: “Increase in ocean wave energy observed in Earth’s seismic wave field since the late 20th century” by Richard C. Astor, Adam T. Ringler, Robert E. Anthony, and Thomas A. Lee, October 32, 2023 , nature communications.
DOI: 10.1038/s41467-023-42673-w

This research was funded by the U.S. Geological Survey and the National Science Foundation.

Source: scitechdaily.com

China finds new species of toothless pterosaur

Chinese and Brazilian paleontologists identify new species of Chaoyangpteri pterosaurs from two specimens, one of which is the most complete and well-preserved Chaoyangpteri pterosaur ever recorded. It was announced that.



rebuilding the life of Meilifeilong Youhao. Image credit: Maurilio Oliveira.

This new species of pterosaur lived in what is now China during the Early Cretaceous period, between 125 and 113 million years ago.

Flying reptiles belong to Chamopteraa family of medium-sized and high-crowned pterosaurs known primarily from Asia.

dubbing Meilifeilong Youhaothis species was part of the Jehor biota, a terrestrial and freshwater ecosystem preserved within multilayered rock formations in northeastern China.

“Pterosaurs are an important and enigmatic group of flying reptiles of the Mesozoic Era that were among the first vertebrates to evolve active flight, and have filled every aerial environmental niche for almost 160 million years.” said Dr. Xiaolin Wang of the Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences. Academy of Sciences and its colleagues.

“Despite being a completely extinct group, they acquired a wide variety of morphologies during the period from the Late Triassic to the end of the Cretaceous.”

“Despite being found on every continent, China stands out by providing several new specimens that reveal not only different species, but also entire new clades, such as the azhdarchoid Chrysoptera.”

“This Cretaceous group of medium-sized and high-crowned pterosaurs is particularly well known from the Jehol biota. Chaoyangopterus zangi and Shenjoupterus chaoyangensis (At the time of description, the posterior region of the skull of Chaoyanptidae was the only one preserved, revealing that these toothless pterosaurs formed a new clade).



holotype of Meilifeilong Youhao; arrow indicates preserved soft tissue.Image credit: Wang other., doi: 10.1038/s41598-023-48076-7.

Two fossilized bodies Meilifeilong Youhao It was discovered in the Jiufutang Formation in Wuludao City, Liaoning Province, China.

“This holotype is particularly well preserved and represents an individual with a wingspan of up to approximately 2.16 meters (7.1 feet),” the paleontologists said.

“It consists of essentially all bones except for most of the tail, making it the most complete and well-preserved Chaoyanputid skeleton ever discovered.”

“The specimen mentioned consists only of the premaxilla and maxilla and anterior part of the palate and represents a smaller individual.”

size Meilifeilong Youhao basically the same as Meilifeiron Sanyainus (with a wingspan of 2.18 meters, or 7.2 feet), which, along with other characteristics, suggests that they represent different species of the same genus.

“This new species provides some new information about these rather enigmatic flying reptiles. palatal area” said the researchers.

“Additionally, it shows a stapes preserved in place, a rare phenomenon among pterosaurs.”

team’s paper Published in the Journal on December 21, 2023 scientific report.

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X-One other. 2023. A new toothless pterosaur from the Early Cretaceous Jehol biota. With comments on Chaoyoptera. science officer 13, 22642; doi: 10.1038/s41598-023-48076-7

Source: www.sci.news

Safeguarding Poison Dart Frogs from Their Lethal Toxins

Scientists have discovered a “toxin sponge” protein in poison dart frogs that safely stores dangerous alkaloids, offering the possibility of a new approach to treating poisoning in humans. (Artist’s concept) Credit: SciTechDaily.com

The newly identified protein helps poison dart frogs accumulate and store powerful toxins in their skin that they use in self-defense against predators.

Scientists announced that they have identified a protein that helps poison dart frogs safely accumulate their namesake toxin, according to a study published Dec. 19 in the journal Nature. e-life.

The discovery solves a long-standing scientific mystery and could suggest potential therapeutic strategies to treat humans addicted to similar molecules.

Alkaloids: from coffee to frog skin

Alkaloid compounds such as caffeine make coffee, tea, and chocolate delicious and comforting, but they can be harmful if consumed in large amounts. In humans, the liver can safely metabolize moderate amounts of these compounds. Small poison dart frogs ingest far more toxic alkaloids in their diet, but instead of breaking them down, they accumulate them in their skin as a defense mechanism against predators.

“It has long been a mystery how poison dart frogs are able to transport highly toxic alkaloids into their bodies without being poisonous themselves,” said lead author and doctoral student in the Department of Biology at Stanford University in California, USA. Aurora Álvarez Buira says. “We aimed to answer this question by searching for proteins that could bind and safely transport alkaloids in poison dart frog blood.”

Diablito poison dart frog, Uofaga Silvatica, native to Colombia and Ecuador. Credit: Marie-Therese Fischer (CC BY 4.0)

Uncover the secrets of frogs

Alvarez-Buylla and colleagues used compounds similar to poison dart frog alkaloids as a kind of “molecular fishing hook” to attract and bind proteins in blood samples taken from poison dart frogs. The alkaloid-like compounds were bioengineered to glow under fluorescent lights, allowing the researchers to watch proteins bind to the decoys.

They then separated the proteins to see how each protein interacted with the alkaloids in solution. They discovered that a protein called alkaloid-binding globulin (ABG) acts like a “toxin sponge” that collects alkaloids. They also identified how proteins bind to alkaloids by systematically testing which parts of the protein are needed to successfully bind the alkaloids.

Impact on humans and future research

“The way that ABG binds to alkaloids is similar to the way that proteins that transport hormones in human blood bind to their targets,” Álvarez Buira explains. “This finding may suggest that hormone-processing proteins in frogs have evolved the ability to manage alkaloid toxins.”

The authors say the similarities with human hormone transport proteins could be a starting point for scientists to try bioengineering human proteins that “sponge” with toxins. “If successful, these efforts could provide new ways to treat certain addictions,” said lead author Lauren O’Connell, an assistant professor of biology at Stanford University and a member of the Wu Tsai Institute for Neuroscience. he says.

“Beyond potential medical relevance, we have achieved a molecular understanding of a fundamental part of poison dart frog biology, which will inform future research on biodiversity and the evolution of natural chemical defenses.” “This will be important for research,” concludes O’Connell.

Reference: “Binding and isolation of poison dart frog alkaloids” plasma Aurora Alvarez Buira, Marie Therese Fisher, Maria Dolores Moya Garzon, Alexandra E. Rangel, Elisio E. Tapia, Julia T. Tanzo, H. Tom So, Luis A. Coloma, Written by Jonathan Z. Long and Lauren A. O’Connell, December 19, 2023. e-life.
DOI: doi:10.7554/eLife.85096

Funding: National Science Foundation, New York Stem Cell Foundation, National Science Foundation Graduate Research Fellowship Program, Howard Hughes Medical Institute, Alfonso Martín Escudero Foundation, Wu Tsai Human Performance Alliance.

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Revolutionary Solid-State Thermal Transistor Unveiled by UCLA

UCLA researchers have unveiled a new solid-state thermal transistor that uses electric fields to effectively control the movement of heat in semiconductors. This represents a major advance in the thermal management of computer chips and potential applications in understanding the thermal regulation of the human body. An illustration of a UCLA-developed solid-state thermal transistor that uses electric fields to control heat transfer. Credit: H-Lab/UCLA

New electronic devices precisely and quickly control turning heat on and off.

A team of UCLA scientists has unveiled the first stable, fully solid-state thermal transistor of its kind that uses electric fields to control thermal movement in semiconductor devices.

Group research recently published in journals scienceLet’s take a closer look at how the device works and its potential uses. With the highest speed and performance, this transistor could break new ground in thermal management in computer chips through atomic-level design and molecular engineering. This advance could also improve our understanding of how the human body regulates heat.

A leap forward in thermal management technology

“Precise control over how heat flows through materials has long been a dream of physicists and engineers, but an elusive dream,” said co-author of the study, a professor of mechanical and aerospace engineering. Professor Yongji Hu said. DOI: 10.1126/science.abo4297

Other authors on the paper, all from UCLA, include Man Li, Huan Wu, Erin Avery, Zihao Qin, Dominic Goronzy, Huu Duy Nguyen, and Tianhan Liu. Hu and Weiss are also affiliated with the California NanoSystems Institute and UCLA Samueli’s Department of Bioengineering and Department of Materials Science and Engineering.

This research

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The influence of ancient Neanderthal DNA on modern daily routines

Recent research has revealed a link between Neanderthal genetics and the tendency of some modern humans to wake up early. The study traces back to the interbreeding of modern humans and Neanderthals in Eurasia and suggests that genetic variation in Neanderthals influences the circadian rhythms of modern human descendants. Credit: SciTechDaily.com

A new paper has been published in a magazine Genome biology and evolutionAccording to a paper published by Oxford University Press, genetic material from Neanderthal ancestors may have contributed to the tendency of some people today to be “early risers” – the type of people who find it easier to get up early and go to bed. I discovered that there is a possibility that

Human evolution and genetic adaptation

All anatomically modern humans trace their origins to Africa about 300,000 years ago, where environmental factors shaped many of their biological characteristics. About 70,000 years ago, the ancestors of modern Eurasian humans began migrating into Eurasia, where they encountered a variety of new environments, including high latitude regions with large seasonal fluctuations in sunlight and temperature.

But other hominins, such as Neanderthals and Denisovans, lived in Eurasia for more than 400,000 years. These archaic humans diverged from modern humans about 700,000 years ago, and as a result, our ancestors and archaic humans evolved under different environmental conditions. This led to the accumulation of strain-specific genetic variation and phenotypes. When humans came to Eurasia, they interbred with archaic humans from the continent. This created the possibility for humans to acquire genetic variations already adapted to these new environments.

Genes of ancient humans and characteristics of modern humans

Although previous studies have shown that many of the archaic ancestors of modern humans are not beneficial and have been removed by natural selection, some archaic hominin variants that remain in human populations has shown evidence of adaptation. For example, archaic genetic variation is thought to be associated with differences in hemoglobin levels, immune resistance to new pathogens, levels of skin pigmentation, and fat composition among Tibetans at high altitudes.

Changes in patterns and levels of light exposure have biological and behavioral effects that lead to evolutionary adaptations. Scientists have extensively studied the evolution of circadian adaptations in insects, plants, and fish, but humans have been less well studied. The Eurasian environment where Neanderthals and Denisovans lived for hundreds of thousands of years is located at higher latitudes and has more variable daylight hours than where modern humans evolved before leaving Africa. So the researchers investigated whether there was genetic evidence for differences in circadian clocks between Neanderthals and modern humans.

Research methods and findings

The researchers defined a set of 246 circadian genes using a combination of literature searches and expert knowledge. They found hundreds of genetic variations unique to each strain that can affect genes involved in the circadian clock. Using artificial intelligence techniques, they identified 28 circadian genes that contain mutations that could alter splicing in archaic humans and that may be differentially regulated between modern and archaic humans. identified 16 circadian genes.

This indicates that there may be functional differences between the circadian clocks of ancient and modern humans. Eurasian modern humans and Neanderthal ancestors interbred, so some humans may have acquired circadian variation from Neanderthals.

To test this, the researchers studied a large population of hundreds of thousands of people in the UK Biobank and found that introgressed genetic mutations (mutations that passed from Neanderthals to modern humans) could affect wakefulness and sleep. We investigated whether there is a relationship with physical preference for. They discovered a number of introgressed mutants that affected sleep preferences, and most surprisingly, they found that these mutants consistently increased morningness, or the tendency to rise early. This suggests a directional influence on this trait and is consistent with adaptations to high latitudes observed in other animals.

Increased morning time in humans is associated with a shortened circadian clock period. This may be beneficial at high latitudes, as it has been shown that sleep and wakefulness can be coordinated more quickly with external timing cues. Shortening of the circadian period is required to synchronize with the long summer light period at high latitudes in Drosophila, and selection for a shorter circadian period results in the latitudinal period decreasing with increasing latitude in natural Drosophila populations. There is a latitudinal gradient in which the

Therefore, the bias toward morningness in introgressed mutants may indicate selection for shortened circadian periods in populations living at high latitudes. The tendency to be a morning person may have been evolutionarily beneficial to our ancestors who lived in the high latitudes of Europe, and would have been a Neanderthal genetic trait worth preserving.

“By combining ancient times, DNA“After extensive genetic and artificial intelligence research in modern humans, we discovered substantial genetic differences in the circadian systems of Neanderthals and modern humans,” said John, lead author of the paper.・A. Capra said.

“And by analyzing Neanderthal DNA fragments that remain in the genomes of modern humans, we discovered surprising trends, many of which affect the regulation of circadian genes in modern humans. These effects are primarily in the consistent direction of increasing Neanderthal tendencies.” Morning people. This change is consistent with the effects of living at high latitudes on animals’ circadian clocks, which may allow them to adjust more quickly to changing seasonal light patterns.

“Our next steps include applying these analyzes to more diverse modern human populations and investigating the effects of the Neanderthal variants we identified on circadian clocks in model systems. and applying similar analyzes to other potentially adaptive traits.”

Reference: “Archaic Introgression Shaped Human Circadian Traits” by Keila Velazquez-Arcelay, Laura L Colbran, Evonne McArthur, Colin M Brand, David C Rinker, Justin K Siemann, Douglas G McMahon, John A Capra, December 14, 2023 , Genome biology and evolution.
DOI: 10.1093/gbe/evad203

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Hidden Secrets of Atomic Structure Uncovered by Scientists

Groundbreaking research led by Professor Motoki Shiga has unraveled the complex atomic structure of glass, revealing its unique patterns and anisotropy. This research paves the way for advanced exploration of glass materials using AI and machine learning techniques.Credit: Motoki Shiga

Glass is an essential material in our daily life and serves a variety of purposes, such as insulating our homes and forming the screens of our computers and smartphones. However, its widespread historical use stands in contrast to the scientific mystery posed by its disordered atomic structure. This puzzling arrangement of atoms complicates efforts to fully understand and manipulate the structural properties of glasses. Therefore, designing effective functional materials from glass remains a difficult challenge for scientists.

Advances in glass research

To further elucidate the structural regularities hidden in glassy materials, the research group focused on the ring shape of the chemically bonded glass network. A research group including Professor Motoki Shiga of Tohoku University’s unprecedented scale data analysis center has developed a new method to quantify the three-dimensional structure of the ring and the symmetry of the structure, “roundness” and “roughness.”

Spatial atomic density around rings of silica crystal (left) and glass (right). Blue and red regions indicate areas with high density of silicon and oxygen atoms, respectively.Credit: Motoki Shiga et al.

Breakthroughs and future directions

“Structural units and structural order beyond chemical bonds have long been inferred through experimental observations, but until now scientists have avoided identifying them,” Professor Shiga says. “Furthermore, our successful analysis contributes to the understanding of phase transitions such as vitrification and crystallization in materials and provides the necessary mathematical explanations to control the structure and material properties of materials.”

Looking to the future, Shiga and his colleagues plan to use these techniques to devise procedures for exploring glass materials, procedures based on data-driven approaches such as: machine learning And AI.

Reference: “Ring-derived anisotropy of local structural order in amorphous and crystalline silicon dioxide” by Motoki Shiga, Akihiko Hirata, Yohei Onodera, and Hirokazu Masai, November 3, 2023. Communication materials.
DOI: 10.1038/s43246-023-00416-w

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Hubble’s remarkable clarity reveals ring-spoke phenomenon

This photo of Saturn was taken by NASA’s Hubble Space Telescope on , when the ringed planet was about 850 million miles from Earth. Hubble’s razor-sharp vision reveals a phenomenon called ring spokes.

Saturn’s spokes are temporary features that rotate with the rings. Their ghostly appearance only lasts for two or three revolutions around Saturn. During the active period, newly formed spokes continually add to the pattern.

Credit: NASA, ESA, STScI, Amy Simon (NASA-GSFC)

Floating Dust rides a merry-go-round around a huge ring world

However Saturn

Its unusual-looking “cup-handle” feature was first noted by Galileo in 1610, but it took another 45 years before it was described by Christian Huygens as a disk surrounding Saturn. Ground-based telescopes were then able to identify only four unique concentric circles, labeled A, B, C, and D. It could not be identified until the 1980s. NASA

The two Voyager spacecraft will fly close to Saturn and photograph thousands of concentric ringlets. An even bigger surprise for Voyager scientists was the dark, radial, spoke-like pattern on the ring’s surface that moved back and forth as it orbited Saturn.

Over the past 30 years, hubble space telescope Voyager picked up where it left off. Hubble’s ultra-clear vision is the next best thing to being there. Hubble follows a “merry-go-round” of ring spokes every year. The black spokes are believed to be dust particles suspended by static electricity above the ring surface. They seem to vary richly depending on the seasons of Saturn’s seven years. And this may be related to changes in Saturn’s magnetic field, which is influenced by the solar wind.

This is an annotated version of the image above. Credit: NASA, ESA, STScI, Amy Simon (NASA-GSFC)

Hubble Space Telescope observes Saturn’s ‘spokes season’

This photo of Saturn was taken by NASA’s Hubble Space Telescope on , when the ringed planet was about 850 million miles from Earth. Hubble’s razor-sharp vision reveals a phenomenon called ring spokes.

Saturn’s spokes are temporary features that rotate with the rings. Their ghostly appearance only lasts for two or three revolutions around Saturn. During the active period, newly formed spokes continually add to the pattern.

In , NASA’s Voyager 2 took the first photo of a ring spoke. NASA’s cassini The orbiter also sighted spokes during its 13-year mission, which ended in 2017.

Hubble continues to observe Saturn every year as its spokes come and go. This cycle is captured by Hubble’s Outer Planet Atmospheric Legacy (OPAL) program, which was launched nearly a decade ago to annually monitor weather changes on all four gas giants.

Hubble’s clear images show that the frequency of the spokes’ appearance is seasonal, and they appeared in the OPAL data for the first time in , but only on the morning (left) side of the ring. Long-term monitoring has shown that both the number and contrast of spokes change with Saturn’s seasons. Saturn’s axis is tilted like Earth’s, and its seasons last about seven years.

“We’re heading towards the Saturn equinox, when the spokes are expected to be at their most active, and will remain active for several years to come,” said Amy Simon, OPAL program principal scientist at NASA’s Goddard Space Flight Center in Greenbelt, Maryland. “We expect higher frequencies and darker spokes to appear.” .

This year, these ephemeral structures will appear on both sides of the Earth simultaneously, rotating around the giant world. Although it appears small compared to Saturn, its length and width can extend to more than Earth’s diameter.

“The leading theory is that the spokes are connected to Saturn’s strong magnetic field, and that the Sun is somehow interacting with that field to create the spokes,” Simon said. As Saturn approaches its vernal equinox, Saturn and its rings tilt less away from the Sun. In this configuration, the solar wind could hit Saturn’s massive magnetic field even harder, promoting spoke formation.

Planetary scientists believe that the electrostatic forces generated by this interaction cause the dust and ice to float above the ring, forming the spokes, but even after decades, no theory can fully predict the spokes. . Continued Hubble observations may ultimately help solve the mystery.

The Hubble Space Telescope is an international cooperative project between NASA and ESA. NASA’s Goddard Space Flight Center in Greenbelt, Maryland, manages the telescope. The Space Telescope Science Institute (STScI) in Baltimore, Maryland, conducts science operations for Hubble and Webb. STScI is operated for NASA by the Association of Universities for Astronomical Research in Washington, DC.

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Using laser light to simulate material production

Researchers at Osaka University have simulated the collision of photons with lasers, potentially paving the way to creating matter from light in the laboratory. This advance in quantum physics has the potential to understand the composition of the universe and discover new physics. (Artist’s concept) Credit: SciTechDaily.com

A team led by researchers from Osaka University and the University of California, San Diego has demonstrated how to use simulations to experimentally create materials from light alone. This could one day help test long-standing theories about the composition of the universe.

One of the most shocking predictions of quantum physics is that matter can be created solely from light (or photons), and in fact, objects known as pulsars have accomplished this feat. Although producing matter directly in this way has not been achieved in the laboratory, it could allow further testing of fundamental quantum physics theories and the fundamental makeup of the universe.

In a recently published study, physical review letterA team led by researchers from Osaka University photon– Collision of photons using only lasers. The simplicity of the setup and ease of implementation at currently available laser intensities make it a promising candidate for experimental implementation in the near future.

Image of a self-organizing photon collider driven by intense laser pulses propagating through a plasma.Credit: Yasuhiko Sentoku

Photon-photon collisions are theorized to be the fundamental means by which matter is created in the universe, resulting from Einstein’s famous equation E=mc2. In fact, researchers have created materials indirectly from light by accelerating metal ions, such as gold, into each other at high speeds. At such high velocities, each ion is surrounded by photons, creating matter and antimatter as they pass each other.

However, it is difficult to generate materials experimentally using laser light alone in modern laboratories, as very high-power lasers are required. The researchers set out to simulate how this feat is accomplished in the lab because it could lead to experimental breakthroughs.

“Our simulations show that when interacting with the laser’s strong electromagnetic field, a dense plasma It can self-assemble to form a photon-photon collider,” explains Dr. Sugimoto, lead author of the study. “This collider contains a population of gamma rays that is 10 times denser than the electron density in the plasma, and whose energy is a million times greater than the energy of the photons in the laser.”

Self-organizing photon collider driven by intense laser pulses. (a) Plasma density, (b) magnetic channel, and (c) angular distribution of emitted photons. Credit: Physical Review Letters

Photon-photon collisions in a collider produce electron-positron pairs, which are accelerated by a plasma electric field generated by a laser. This produces a positron beam.

“This is the first simulation of an accelerated positron from a linear Breit-Wheeler process under relativistic conditions,” said co-author Professor Alefeyev from UCSD. “We feel that our proposal is experimentally feasible and we look forward to real-world implementation,” said Dr. Vyacheslav Lukin, program director at the National Science Foundation, which supported the research. It is stated as follows. “This research shows a potential way to explore the mysteries of the universe in a laboratory setting. The future possibilities for current and future high-power laser facilities have become even more interesting.”

Applying this research to Star Trek’s fictional matter and energy conversion technology remains mere fiction. Nevertheless, this research has the potential to help experimentally confirm theories of the composition of the universe, and may even help discover previously unknown physics.

Reference: “Positron generation and acceleration in a self-organizing photon collider enabled by ultra-intense laser pulses” K. Sugimoto, Y. He, N. Iwata, Illinois. Yeh, K. Tantartalakul, A. Alefyev, Y. Szenk, August 9, 2023. physical review letter.
DOI: 10.1103/PhysRevLett.131.065102

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The CHOOSE system unveils insights into autism




IMBA – Institute of Molecular Biotechnology, Austrian Academy of Sciences

December 25, 2023

A breakthrough in autism research has been achieved with the CHOOSE system developed by researchers at IMBA and ETH Zurich. This technology enables detailed study of genetic mutations in human brain organoids, providing deep insight into the mechanisms underlying autism and paving the way for applications in broader disease research.

The CHOOSE system is an innovative approach that combines brain organoids and genetics to transform autism research by enabling detailed analysis of mutations and their impact on brain development.

Does the human brain have an Achilles heel that ultimately leads to autism? With an innovative new system that combines brain organoid technology and complex genetics, researchers are now able to identify multiple It is now possible to comprehensively test the effects of mutations in parallel at the single-cell level.

The technology was developed by researchers from the Knoblich Group at the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences and the Treutlein Group at ETH Zurich and aims to identify the vulnerable cell types that underlie autism spectrum disorders. Enables identification of gene regulatory networks. This innovative method provides unparalleled insight into one of the most complex disorders that challenges the human brain and brings much-needed hope to clinical research in autism.

Human brain development and ASD riskcompared to other animals seed, the human brain has a mind of its own. The human brain relies on uniquely human processes to develop and is able to build a complex, layered and interconnected cortex. These unique processes also predispose humans to neurodevelopmental disorders.

As an example, many genes confer a high risk of developing autism spectrum disorder (ASD) is essential for cortical development. Clinical studies have shown a causal link between multiple genetic mutations and autism, but researchers still do not understand how these mutations lead to impaired brain development. . Additionally, the uniqueness of human brain development limits the use of animal models.

Only human brain models can reproduce the complexity and specificity of the human brain,” says IMBA Scientific Director Jürgen Knoblich, one of the study’s corresponding authors.

Left half: Confocal image of CHOOSE (CRISPR-humanorganoids-scRNA-seq) human brain organoid mosaic system. Cells with mutations are shown in red. Right half: Mosaic depiction of different colors representing a single cell. Each cell carries a mutation in one high-confidence autism gene.

Credit: ©Knoblich Lab / IMBA-IMP Graphics

Innovative CHOOSE system for genetic screeningTo unravel this black box, researchers from IMBA and the research group of Jürgen Knoblich and Barbara Treutlein at ETH Zurich have identified a complete set of key transcriptional regulatory genes associated with autism. We have developed a screening technology. This development is particularly impactful because it allows for the simultaneous testing of genes of interest within a single mosaic organoid, marking the beginning of an era of complex, efficient, and rapid genetic screening in human tissues.


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The Missoula Glacier Lake’s impact on the dramatic scaly area

Satellite image of parts of Akaland taken on May 14, 2023 by Landsat 8’s Operational Land Imager.

Ejecta from Missoula Glacier Lake has carved out channeled skeletal lands in Washington state.

Southeastern Washington is home to miles of rolling hills and a neat grid of farmland. Dozens of crops It is grown on precious farmland on the Columbia Plateau. But in some places, undulating streaks of scoured soil interrupt a series of angular plots or center-pivot irrigated fields.

These rocky scars channeled scrubland, and they were formed in a series of dramatic floods 10,000 to 20,000 years ago. Landsat 8’s OLI (Operational Land Imager) captured the image of part of Acarland, about 120 kilometers (75 miles) west of Spokane, on May 14, 2023.

The sources of water that carved these unusual landforms remained a mystery to geologists for decades. Then they came to understand that as the Cordilleran Ice Sheet moved south during the last ice age, it formed dams along the Clark Fork River. Glacial Lake Missoula grew behind this ice dam in what is now western Montana and eventually held as much water as Lake Erie and Lake Ontario combined. Geologists estimate that: a dam was formed and broke dozens of times Over thousands of years, each breach releases up to 600 cubic miles of water across the region.

Detailed view of the image above.

Floodwaters flowed south and southwest, eventually emptying into the Columbia River. In the process, they carved grooves, potholes, and long channels known as “coulees” into the volcanic basalt bedrock. The detailed map (above) shows one of these channels and reveals the striking contrast between flood scoured areas and arable land.

The canyon shown here is small compared to the others. Grand Coulee, the largest of the Channeled Scrublands north of this scene. Completed in 1942, Grand Coulee Dam was the largest concrete structure in the world until it was surpassed by dams in South America. Itaipu Dam 1984 and China three gorges dam Established in 2006.Currently America’s largest hydroelectric facility Provides irrigation water to the Columbia Plateau.

NASA Earth Observatory imagery by Lauren Dauphin using Landsat data from the U.S. Geological Survey.

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Artificial Intelligence Will Not Eliminate Jobs, Despite Common Misconceptions.

by

New research reveals that work experience has a significant impact on how employees interact with AI. Employees with more experience with a particular task will benefit more from AI, but senior employees will be less likely to trust her AI due to concerns about its imperfections. The findings highlight the need for customized strategies when integrating AI into the workplace to enhance human-AI teamwork.

New research sheds light on the complex aspects of human-AI interaction and reveals some surprising trends. Artificial intelligence systems tend to benefit younger employees, but not for the reasons you might expect.

New research published in INFORMS journal Business Administration provides valuable insights to business leaders about the impact of work experience on employees’ interactions with artificial intelligence.

In this study, two main forms of human work experience—narrow experience defined by the amount of specific tasks and broad experience characterized by overall seniority—were used to examine the dynamics within human-AI teams. We are investigating the impact on

Surprising findings from medical record coding research

“We developed an AI solution for medical record coding at a publicly traded company and conducted field research with knowledge workers,” says Weiguang Wang of the University of Rochester. “We were surprised by what we found in our research: Different dimensions of work experience clearly interact with AI and play a unique role in human-AI teaming.”

“While some might think that less experienced workers should benefit more from the help of AI, we find the opposite, that AI benefits workers with more task-based experience. At the same time, even though senior employees have more experience, they gain less from AI than junior employees,” said Guodong (Gordon) Gao, Johns Hopkins Carey School of Business. says.

Seniority and AI trust dilemma

Further research revealed that the relatively low productivity gains from AI were not the result of seniority per se, but rather a high sensitivity to imperfections in AI, which led to a decline in trust in AI. .

“This finding presents a dilemma: Experienced employees are well-positioned to leverage AI for productivity, but senior employees who take on greater responsibility and care about their organization They tend to avoid AI because they are aware of the risks of relying on it.” Aid. As a result, they are not using AI effectively,” said study co-author Ritu Agarwal of the Johns Hopkins Carey School of Business.

The researchers urge employers to carefully consider the types and levels of experience of different workers when implementing AI into jobs. New employees with little work experience are at a disadvantage when it comes to utilizing her AI. On the other hand, senior employees with more experience in an organization may be concerned about the potential risks posed by AI. Addressing these unique challenges is key to productive human-AI teaming.

Reference: “Friend or enemy? Artificial Intelligence and Teaming Workers with Different Experiences” Weiguang Wang, Guodong (Gordon) Gao, Ritu Agarwal, October 11, 2023. Business Administration.
DOI: 10.1287/mnsc.2021.00588

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The transformation of seedlings into super plants through a rare chemical scent

plants by exposing them to certain chemicals at seed can affect subsequent growth. Researchers found that treating seeds with ethylene gas improved both growth and stress tolerance. This finding includes enhanced photosynthesis. Carbohydrate production in plants has the potential to be a breakthrough in improving crop yields and resilience to environmental stressors. Like other living things, plants can be stressed. Usually the conditions are as follows heat and drought. That can lead to stress, and when stressed, the plant may not grow as much or produce less. This can be a problem for farmers, so many scientists have tried genetically modified plants to make it more elastic. However, plants modified to obtain higher crop yields are low stress tolerance. This is because they put more energy into growing than protecting them from stress. Similarly, as plants improve their ability to withstand stress, production often decreases because they spend more energy protecting than growing. This brainteaser makes it possible It is difficult to improve crop yields. I was studying How the plant hormone ethylene regulates plant growth and stress responses. In Research to be published in July 2023, my lab made an unexpected and provocative observation. We found that when seeds that are normally underground germinate in the dark, adding ethylene improves both growth and stress tolerance. Ethylene is a plant hormone Because plants cannot move around, they cannot avoid stressful environmental conditions such as heat or drought. They receive various signals from their environment, such as light and temperature, which shape their growth, development, and how they respond to stressful situations. As part of this regulation, plants make various hormones They are part of a regulatory network that allows them to adapt to environmental conditions. Ethylene was first discovered as a gaseous plant hormone over 100 years ago. Since then, research has shown that all land plants studied produce ethylene. In addition to controlling growth and responding to stress, they are also involved in other processes, such as turning leaves in autumn and promoting fruit ripening. Ethylene as a way to “prime” plants My lab focuses on how plants and bacteria sense ethylene and how ethylene interacts with other hormonal pathways to regulate plant development. While conducting this research, my group accidental discovery. We were experimenting with germinating seeds in a dark room. Seed germination is a critical period in a plant’s life when seeds transition from dormancy to seedlings under favorable conditions. In this experiment, Seeds exposed to ethylene gas Continue this for a few days to see what effect it has. The ethylene was then removed. Normally, the experiment should end here. However, after collecting data on these seedlings, we transferred them to lightweight carts. This is not something we normally do, but we wanted to grow the plants to adulthood so we could have seeds for future experiments. After a few days of placing the seedlings under light, some lab members made the unexpected and surprising observation that the plants briefly gassed with ethylene. it was much bigger. These plants had larger leaves and longer and more complex root systems than plants not exposed to ethylene. These plants continued to grow at a faster rate throughout their lives. The plant on the left was not primed with ethylene, while the plant on the right was primed with ethylene. Both plants are the same age. Credit: Binder Lab, University of Tennessee, Knoxville My colleagues and I wanted to know if plants are diverse seed Exposure to ethylene during seed germination showed growth stimulation. We discovered it the answer is yes. We tested the effects of short-term ethylene treatment on germinating tomato, cucumber, wheat, and arugula seeds, all of which grew significantly. However, what made this observation unusual and exciting is that short ethylene treatments also Increased tolerance to various stresses salinity stress, high temperature, hypoxic conditions, etc. The long-term effects of short-term exposure to a stimulus on growth and stress tolerance are often referred to as priming effects. This can be thought of as pump priming priming allows the pump to start easier and faster. There are studies that investigated how plants grow after priming at different ages and developmental stages. but Seed priming Methods using various chemicals and stress are probably the most studied because they are easy to implement and, if successful, can be…

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1.5 Billion Pixel Masterpiece Captures The Running Chicken Nebula

The Running Chicken Nebula is made up of several clouds, all of which can be seen in this expansive image from the VLT Survey Telescope (VST) hosted at ESO’s Paranal Site. His 1.5 billion pixel image spans an area of ​​the sky the size of about 25 full moons. The cloud, marked by a wispy pink plume, is filled with gas and dust and lit by young, hot stars within it. Credit: ESO/VPHAS+ Team. Acknowledgment: CASU

of ESO has released a detailed image of the Running Chicken Nebula, located 6,500 light-years away in the constellation Centauri. This 1.5 billion pixel image of his captured by VST highlights young stars and regions such as IC 2948 and IC 2944, providing a cosmic treat for the eyes.

Many holiday traditions include a feast of turkey, buckwheat, latkes, or pan de pascua, but this year the European Southern Observatory (ESO) is bringing you the holiday chicken. The so-called Running Chicken Nebula, home to the birth of young stars, is revealed in stunning detail in this 1.5 billion pixel image captured by the VLT Survey Telescope (VST) at ESO’s Paranal Site in Chile. It has become.

This vast stellar nursery is located in the constellation Centaurus, about 6,500 light-years from Earth. Young stars in this nebula emit intense radiation that makes the surrounding hydrogen gas glow pink.

The Running Chicken Nebula is actually made up of several regions, all of which can be seen in this vast image spanning an area of ​​the sky the size of about 25 full moons.[1] The brightest region in the nebula is called IC 2948, where some people can see the head of a chicken, while others can see the back end. The wispy pastel outlines are fantastic plumes of gas and dust. His IC 2944 is characterized by a bright vertical, almost columnar structure towards the center of the image. The brightest sparkle in this particular area is lambda centauria star visible to the naked eye that is much closer to us than the nebula itself.

The Running Chicken Nebula is made up of several clouds, the most prominent of which are labeled in this expansive image from the VLT Survey Telescope (VST) hosted at ESO’s Paranal Site. The bright star, named Lambda Centauri, is actually much closer than the nebula itself and can be seen with the naked eye. The cloud, marked by a faint pink plume, is filled with gas and dust and lit by young, hot stars within it. In total, this image spans an area of ​​about 25 full moons in the sky, one of which is shown to scale for reference. Credit: ESO/VPHAS+ Team. Acknowledgment: CASU

But IC 2948 and IC 2944 themselves are full of young stars. And while they may be bright, they are definitely not cheerful. They tear through the environment like chickens, spewing massive amounts of radiation. Some regions of the nebula, known as Bok globules, can withstand the intense assault of ultraviolet radiation that spreads through this region. If you zoom in on the image, you may see small, dark pockets of dense dust and gas scattered throughout the nebula.

Other areas pictured here include gums 39 and 40 in the upper right and gum 41 in the lower right. In addition to the nebula, the sky is filled with countless orange, white, and blue stars like fireworks. Overall, this image is a wonder that cannot be explained. Zooming in and moving around the screen can be a feast for the eyes.

This 3D animation of the Running Chicken Nebula imagines what it would be like to fly near a swirling cloud of gas and dust. This video is based on real images from the VLT Survey Telescope hosted on his Paranal site in ESO. However, the 3D positions of the stars shown here are for reference only. Credit: ESO/VPHAS+ Team. Acknowledgment: CASU

This image is a large mosaic made of hundreds of individual frames carefully stitched together. Individual images are taken through filters that pass different colors of light and combined into the final result shown here.Observations were made with a wide-field camera omega cam in VSTis a telescope owned by the Italian National Institute of Astrophysics (INAF) and hosted by ESO at the Paranal site in Chile’s Atacama Desert, perfect for mapping the southern sky in visible light. The data used to create this mosaic were acquired as part of his VST photometric Hα survey of the Southern Galactic Plane and Bulge (VPHAS+), a project aimed at better understanding the life cycle of stars.

This diagram shows the location of the Running Chicken Nebula (IC2944) in the large constellation south of the constellation Centaurus (Centaurus). This map shows most of the stars visible to the naked eye under good conditions, and the location of the nebula itself is marked with a red circle. Although the star cluster associated with this nebula, IC 2948, is easily seen with small telescopes, the nebula is very faint and was only discovered in photographs in the early 20th century. Credits: ESO, IAU, Sky & Telescope

Note

  1. This image spans 270 light years from edge to edge. It takes the average chicken almost 21 billion years to run through it. That’s a long time since our universe has existed.

Access full size 3.9 GB image here.

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Harnessing the potential of innovative algorithms

Immune system researchers have designed a computational tool to improve pandemic preparedness. Scientists can use this new algorithm to compare data from very different experiments and more accurately predict how individuals will respond to disease.

“While we are trying to understand how individuals fight off different viruses, the advantage of our method is that it can be applied to other organisms, such as comparing different drugs or different cancer cell lines. It has general applicability in academic settings,” says Dr. Tal Einab. D., La Jolla Institute of Immunology (LJI) assistant professor and co-leader of the new study.

This study addresses a major challenge in medical research. Labs that study infectious diseases collect very different types of data, even those that focus on the same virus. “Each dataset becomes its own independent island,” he says Einav.

Working closely with Dr. Rong Ma, a postdoctoral fellow at Stanford University, Einav set out to develop an algorithm to help compare large datasets. His inspiration comes from a background in physics, where scientists can be confident that their data falls within the known laws of physics, no matter how innovative the experiment. E is always equal to mc2.

For example, researchers may be able to design better vaccines by understanding exactly how human antibodies target viral proteins.

The new method is also thorough enough to give scientists confidence behind their predictions. In statistics, a “confidence interval” is a way to quantify how certain a scientist’s predictions are.

“When people from different backgrounds come together, there is great synergy,” says Einab. “With the right team, we can finally solve these big unsolved problems.”

Tal Einav and Rong Ma, “Using Interpretable Machine Learning to Augment Heterogeneous Antibody Virus Datasets,” July 25, 2023, cell report method.

Source: scitechdaily.com

The Impact of NASA’s Reflectors on Our World

GPS satellites play a crucial role in Earth measurements by relaying information to other satellites. Laser retroreflector arrays (LRA) have emerged as a technological advancement that enhances the precision of geodesy, the study of the Earth’s shape and changes. LRAs enable the collection of precise distance measurements necessary for monitoring global phenomena like sea level rise and tectonic movements. They work by reflecting laser light back to its original source, allowing scientists to accurately measure changes in the Earth’s surface.

Numerous federal agencies, including NASA, the U.S. Space Command, U.S. Naval Research Laboratory, and the National Geospatial-Intelligence Agency, have been involved in improving the accuracy of Earth measurements. The use of LRAs has allowed geolocation of all Earth observations to improve, enabling scientists to strategize and anticipate changes in the Earth’s angular momentum, changes in the Earth’s figure, and significant geodetic factors.

Laser retroreflector arrays function by reflecting light directly back towards its original source, as they consist of mirrors placed at right angles. They are instrumental in providing precise location information to ground stations on Earth, aiding in pinpointing the Earth’s center of mass and aiding in geodetic measurements. The ability to measure minute changes in the Earth’s center of gravity is of utmost importance as it aids in quantifying and understanding larger shifts resulting from events like tsunamis or earthquakes.

Overall, the implementation of laser retroreflector arrays is essential in studying Earth’s shape, gravity, and rotation, as well as determining changes over time. It is a fundamental component of daily life that aids in understanding how the world is changing.

Source: scitechdaily.com

Future Liquid Hydrogen Fuel Could Be Provided by a New Catalyst

Researchers are developing a hydrogen-based vehicle fuel system that uses catalytically converted liquids and has zero greenhouse gas emissions. Although this method is still being researched, it faces challenges such as catalyst durability and the environmental friendliness of hydrogen production, highlighting the need for political support for renewable energy.

Researchers at Sweden’s Lund University have developed an innovative vehicle fuel system that minimizes greenhouse gas emissions and operates in a circular manner. The system utilizes a unique liquid that, when combined with a solid catalyst, turns into hydrogen fuel for cars. After use, the used fluid is removed from the vehicle’s tank and refilled with hydrogen, making it available for reuse. This process forms a closed-loop system that significantly reduces environmental impact.

In two research papers, Lund researchers have demonstrated that the method works, and although it is still basic research, it has the potential to become an efficient energy storage system in the future.

“Our catalyst is one of the most efficient, at least according to published studies,” says one of the authors, Ola Wendt, professor in the Department of Chemistry at Lund University.

Addressing climate impacts and exploring hydrogen gas

Reducing our climate impact requires finding alternative ways to produce, store, and convert energy to reduce carbon emissions from fossil fuels. One method involves the hot topic of hydrogen gas, which many see as the future solution for energy storage. Nature stores energy through chemical bonds, and hydrogen contains the highest energy density relative to its weight.

“But gas can be difficult to handle, so we are looking at hydrogen-filled liquid fuels that can be delivered at the pump, in much the same way as is done at gas stations today.” Ola Wendt he says.

This concept is known as LOHC (Liquid Organic Hydrogen Carrier) and is not new in itself. The challenge is to find the most efficient catalyst possible to extract hydrogen from the liquid.

The system is designed to operate using a liquid “filled” with hydrogen. The liquid is pumped through a solid catalyst to extract the hydrogen. This can be used in fuel cells that convert chemical fuels into electricity, and the “spent” liquid is taken to a separate tank. Only water is expelled.

Refueling and large-scale production

Used fluid can be emptied at a filling station before being refilled with new fill fluid. This would likely mean large-scale production of materials comparable to today’s oil refineries.

“We converted more than 99 percent of the hydrogen gas present in the liquid,” says Ola Wendt.

Researchers are also calculating whether the fuel could be used in larger vehicles such as buses, trucks and airplanes.

“With the larger tanks they have, they might be able to cover about the same distance as a diesel tank. They would also convert about 50% more energy than compressed hydrogen,” says Ola. Wendt says.

Components and challenges

The liquids used are isopropanol (a common ingredient in screen wash) and 4-methylpiperidine.

Does this seem a little too good to be true? Yes, many challenges remain, at least for now. One is that catalysts have a fairly limited lifetime. Another reason is that iridium, which is the basis of the catalyst, is a precious metal.

“However, we estimate that each car requires about 2 grams of iridium. ,” says Ola Wendt.

This is a technical solution based on basic research. Ola Wendt believes that if the decision is made to develop a finished product, the concept could be completed within 10 years if it is economically viable and there is interest from society. I am.

Another issue is how hydrogen is produced. Today, most manufacturing is not climate friendly. Next, hydrogen needs to be stored and transported in an effective way, which is not so easy today. Compressed hydrogen refueling also has risks. Lund researchers hope to solve this problem in their own way.

“Ninety-eight percent of all hydrogen today is fossil-based, produced from natural gas. The byproduct is carbon dioxide. From an environmental perspective, the concept of producing hydrogen for steel, batteries, and fuels is “It makes no sense if it’s done using natural gas,” says Ola Wendt, but explains that a lot of research is being done on how to “produce hydrogen in an environmentally friendly way.” To do. “Hydrogen” can be produced by splitting water into hydrogen and oxygen with the help of renewable energy.

At the same time, Ola Wendt believes that political decisions are needed for renewable and climate-friendly alternatives to gain a proper foothold.

“It needs to be cheaper, and that will require a political decision. Renewable energy has the potential to compete with just digging it out of the ground, where transportation is almost the only cost, as is the case with fossil fuels. There is no gender,” he concludes.

Reference: “Acceptorless dehydrogenation of 4-methylpiperidine over supported pincer-bound iridium catalysts in continuous flow” Kaushik Chakrabarti, Alice Spangenberg, Vasudevan Subramaniyan, Andreas Hederstedt, Omar Y. Abdelaziz, Alexey V. Polukeev, Reine Wallenberg , by Christian P. Hulteberg and Ola F. Wendt, July 27, 2023. Catalyst science and technology.
DOI: 10.1039/D3CY00881A

“Iridium-catalyzed dehydrogenation in a continuous flow reactor for practical on-board hydrogen production from liquid organic hydrogen carriers”, Alexey V. Polukeev, Reine Wallenberg, Jens Uhlig, Christian P. Hulteberg, Ola F. Wendt, March 9, 2022 chemsus chem.
DOI: 10.1002/cssc.202200085

Source: scitechdaily.com

A Unique Patient Mutation Offers New Hope for Preventing Alzheimer’s Disease

Researchers have discovered a unique case in a Colombian family where a woman with a genetic predisposition to Alzheimer’s disease remained cognitively healthy due to a rare APOE gene mutation, the Christchurch mutation. This mutation disrupts the typical progression of Alzheimer’s disease and suggests new prevention strategies. Dementia may be prevented by breaking the link between early and late stages of the disease.

The disease has plagued one large Colombian family for generations, killing half of them in their prime years. But one member of the family avoided what seemed like fate. She remained cognitively healthy well into her 70s, even though her relatives inherited her genetic defect that caused her to develop dementia in her 40s.

Researchers at Washington University School of Medicine in St. Louis now think they know why. Previous research had reported that the woman was in possession of two copies of the rare variant, unlike her relatives. Apoe A gene known as the Christchurch mutation.

In this study, researchers used genetically modified mice to show that the Christchurch mutation was associated with early stages of Alzheimer’s disease, when a protein called amyloid beta accumulates in the brain, and another protein called tau, which causes cognitive impairment. begins to decline. So the women remained mentally alert for decades, even though their brains were filled with large amounts of amyloid.

“All protective factors are very interesting because they give us new clues about how the disease works,” said lead authors Barbara Barton, Ph.D., and Reuben M. said David M. Holzman, M.D., Morris III Professor Emeritus of Neurology.

Understanding the progression of Alzheimer’s disease, the researches found thatthe main difference was the level of activity of microglia, the brain’s waste-processing cells. Microglia tend to cluster around amyloid plaques. In mice with Apoe The Christchurch mutation activated microglia surrounding amyloid plaques, making them highly efficient at consuming and processing tau aggregates.

Reference: “APOE3ch alters microglial responses and suppresses Aβ-induced tau dissemination and spread” Yun Chen, Sihui Song, Samira Parhizkar, Jennifer Lord, Yiyang Zhu, Michael R. Strickland, Chanung Wang, Jiyu Park, G By Travis Tabor, Hong Jiang, Kevin Lee, Albert A. Davis, Carla M. Huede, Marco Colonna, Jason D. Ulrich, David M. Holtzman, December 11, 2023. cell.DOI: 10.1016/j.cell.2023.11.029

Source: scitechdaily.com

15 Exciting Science Riddles to Enjoy Solving with Your Family

1. The most common form of aluminum ore, wild goat, a rectangular array of numbers and radiation with wavelengths from 0.01 to 10 nanometers. What do they all have in common, and why did they make the news this year?

2. Four guests will be seated for Christmas dinner. One came from a valley in Germany. One was good with tools, one was said to be intelligent, and the other wanted a chair with a strong backrest. Three people leave the table one by one. Who will sit last?

3. In 2028, abolitionists and the God of Fire will be joined by crystallographers. where are they?

4. It’s time to gather around the table and bond. First, what can you make from these interesting food combinations?

Sweet nougat + chestnut udon

Chipolatas + Flaming Eggnog

Chocolate unicorn + tangy nachos

Angel gingerbread + Asian plum

5. How about going for a brisk walk to relieve the fatigue of your Christmas meal? Along the way, you’ll see a big dog that’s not on a leash, a big bear that’s not in a cave, and a ring that’s inside. I see a bull that is not there. where are you looking?

6. Hark! The pressure between the ship and its surroundings quickly equalizes, creating a wonderful, festive vibration. What just happened?

7. After receiving the clutch Tsugumi Merulaa trio of Gallus gallus domesticus and some Streptoperia turtlewhere do you think you can find it? Perdix?

8. Chinese giant SkyEye only has one, but labs tend to have a few and Christmas dinners have many. what is that? …

Source: www.newscientist.com

New Hope for Diabetes Treatment: Repurposed Medicines Present Promising Results

A recent study led by Indiana University and the University of Chicago Medicine suggests that a drug called alpha-difluoromethylornithine (DFMO) could revolutionize the treatment of type 1 diabetes. Based on a decade of research, DFMO has demonstrated the potential to reduce insulin dependence, and larger clinical trials are currently underway to evaluate DFMO’s impact on beta cell preservation and disease amelioration. Tested.

A recent study led by Indiana University School of Medicine in collaboration with the University of Chicago School of Medicine shows exciting future possibilities for the management of type 1 diabetes and its potential reduction. insulin dependence. The researchers’ findings are cell report medicine, They suggest that repurposing the drug alpha-difluoromethylornithine (DFMO) could open the door to innovative treatments in the future.

Type 1 diabetes is a chronic disease in which the body’s immune system mistakenly attacks and destroys insulin-producing beta cells in the pancreas, resulting in high blood sugar levels and currently requires lifelong insulin treatment to keep patients alive. Is required. Many people living with type 1 diabetes find current treatments, such as daily insulin injections and frequent blood sugar monitoring, inconvenient and difficult to manage.

A 10-year research journey

These latest translation results represent more than a decade of research. Raghu Mirmila, M.D., Ph.D., co-corresponding author of the study, said in 2010 that while running his lab at IU School of Medicine, his team was able to develop beta It was discovered for the first time that cells can be protected from infection. Environmental factors suggest that type 1 diabetes may be preserved. The team then validated these findings in mice.

From 2015 to 2019, Linda DiMeglio, MD, MPH, Edwin Letzter Professor of Pediatrics at IU School of Medicine, Pediatric Endocrinologist and Division Director at Riley Children’s Health, provided guidance to people with newly diagnosed type 1 diabetes. He led a clinical trial to confirm the safety of DFMO. They also suggested that it may stabilize insulin levels by protecting beta cells. The trial was funded by the Juvenile Diabetes Research Foundation (JDRF) and used the drug provided by Panvera Therapeutics.

Dr. Emily K. Sims. Credit: Chapital Photography, provided by Emily K. Sims

“After several years of bench-to-bedside research, Drs. [Sarah] “We are pleased to finally share the promising results from the Tercy mouse model, a pilot study in humans,” said DiMeglio, senior author of the study. “Having established the preliminary safety of DFMO in patients with type 1 diabetes, we are excited to collaborate to further explore its potential benefits in a larger clinical trial.”

Regulatory benefits of DFMO and new formulations

Since 1990, DFMO has been approved by the FDA as a high-dose injectable to treat African sleeping sickness, and in 2020 received breakthrough therapy designation as a post-remission neuroblastoma maintenance therapy. Ta. This prior regulatory approval could streamline adoption as a treatment for type 1 diabetes and shorten the approval process from decades to just a few years.

“Using the new formulation of DFMO as a pill allows patients to take it by mouth rather than needing regular injections, and it has a very favorable side effect profile,” said Dr. said one Milmira. Chicago Medicine. “We are very happy to be able to say that we have developed a drug that works differently than other treatments for this disease.”

Current and future clinical research

Researchers have already begun the next steps to investigate the potential of DFMO. The study’s lead author and co-corresponding author, Emily K. Sims, M.D., associate professor of pediatrics at IU School of Medicine and pediatric endocrinologist at Riley Children’s Health, recently studied the effects of infectious diseases in more detail. To define it, we have begun a large-scale clinical study involving six institutions. His DFMO treatment to preserve beta cell function in type 1 diabetes. This new research was also funded by JDRF and supported by Panbela Therapeutics.

Sims, who is also a physician and scientist at the IU School of Medicine’s Herman B. Wells Pediatric Research Center and Center for Diabetes and Metabolic Diseases, hopes that DFMO, perhaps as part of a combination therapy, will not only help patients; There is. People who have recently been diagnosed with type 1 diabetes but are at risk of developing the condition may also be tested.

“As we embark on this new multicenter clinical trial to further investigate the efficacy of DFMO, we are confident that the encouraging results obtained to date will allow us to modify the underlying disease process of type 1 diabetes. ”Sims said. “We invite even more participants to this pioneering study. With their help, the knowledge we gain today has the potential to shape a brighter future for people affected by type 1 diabetes. Masu.”

Reference: “Inhibition of polyamine biosynthesis preserves beta cell function in type 1 diabetes” Emily K. Sims, Abhishek Kulkarni, Audrey Hull, Stephanie E. Werner, Suzanne Cabrera, Lucy D. Mastrandrea, Batur Hammoud, Soumyadeep Sarkar, Ernesto S. Nakayas, Teresa L. Mastracci, Susan M. Perkins, Ouyang Fangqian, Bobbie Jo Webb Robertson, Jacob R. Enriquez, Sarah A. Turcy, Carmela Evans. · Molina, S. Alice Long, Lori Blanchfield, Eugene W. Garner, Raghavendra G. Mirmila and Linda A. Dimeglio, November 1, 2023; cell report medicine.
DOI: 10.1016/j.xcrm.2023.101261

People who want to know more about New clinical trials can be accessed on the research website.

Source: scitechdaily.com

Government suggests culling owl population to protect endangered species

The U.S. Fish and Wildlife Service has proposed a plan to shoot hundreds of thousands of barred owls in West Coast forests over the next 30 years, arguing that the survival of one owl species depends on the extinction of another. The spotted owl, not native to the area, is displacing its genetically related barred owl, the bureau said.

Unless action is taken against barred owls, the spotted owl could disappear from parts of Washington and Oregon within a few years and eventually become extinct, according to service biologists.

This proposal is the latest effort to save the spotted owl, whose decline became a rallying point for environmentalists against logging in the Pacific Northwest in the 1980s. This plan raises questions about how far humans should go to save species and the cost of righting historic ecological wrongs, as the barred owls may have become established in the Pacific Northwest under human influence as European settlers spread westward.

The proposal calls for the “lethal removal” (killing with shotguns) of more than 470,000 barred owls in total and is open for public comment until January 16th. It may be difficult for the undiscerning eye to distinguish barred owls from spotted owls, as both have pale faces and mottled brown and white coats and belong to the same genus. However, barred owls are slightly larger, breed faster, are more aggressive, and are less discriminatory about where they live and what they eat.

The spotted owl population has declined by about 75 percent over the past 20 years, primarily due to barred owls, according to the U.S. Fish and Wildlife Service. The plan would eliminate the barred owls from 1-2% of its current range, and the removal of barred owls has been shown to stabilize the spotted owl population, although the impact has not been substantial.

Despite the dominance of barred owls, the population is likely to recover over time, and the cost of righting historic ecological wrongs is still uncertain. Wildlife biologists consulted with an ethicist about killing the animals, and while some animal rights groups disagree with the plan, a final proposal is expected to be released in the spring or summer after the public comment period on the USFWS proposal ends.

Source: www.nbcnews.com

The Top 6 Spectacular Space Photos from 2023

Wolf Rayet star WR 124 glimpsed by JWST

NASA, ESA, CSA, STSCI, ERO production team

The James Webb Space Telescope (JWST) helped make 2023 the year of amazing space images. But this groundbreaking telescope wasn’t the only source of visual wonder. A series of new missions are sending back photos from space, and the view from Earth isn’t bad either. Here are 6 photos that surprised us the most.

The star in the photo above was captured by JWST as it prepared to explode. It’s called WR 124 and has about 30 times the mass of the Sun. When a star that large runs out of hydrogen to burn in its core, heavier elements begin to fuse together. This fusion creates a powerful burst of energy, sending gusts of wind at speeds of millions of kilometers per hour. When these powerful winds strip away the outer layers of a star, it becomes a star known as a Wolf-Rayet star. It will explode as a supernova within a few million years after it peels off. The purple spots in this photo are clouds of dust and gas that were the outer layer of WR 124. It has already lost about 10 times the mass of the Sun. If these layers are not intact, it is doomed to explode into a supernova.

Solar tornado seen from Earth

Andrew McCarthy and Jason Guenzel

Then we have the tallest solar tornado ever recorded (above). The event occurred on March 14, when the rotation of the sun’s magnetic field stirred up plasma near the north pole. This feature rose above the surface of the Sun, and the giant flare reached a height of 178,000 kilometers, or nearly 14 times the diameter of Earth. This image is the result of a careful collaboration between astrophotographers Jason Genzel and Andrew McCarthy. They used high-speed cameras to record the event, and it took him five days and 90,000 individual shots to create the photos. The sun appears furry in this image because it is covered in millions of stirring geysers of plasma, each lasting only a few minutes.

Herbig Halo 211 captured by JWST

ESA/Webb, NASA, CSA, Tom Ray (Dublin)

This bright explosion (above) reveals the newborn star’s incredible supersonic jet. These result in what are known as Herbig-Haro objects. The star itself is hidden within the dark cloud of gas from which it formed, but when jets erupt from its
ides, they collide with surrounding gas and dust, creating huge shock waves that cause them to glow. This particular object, called Helbig Halo 211, is located in the constellation Perseus, about 1000 light-years from Earth.

Jupiter’s moon Io

NASA/JPL-California Institute of Technology/SwRI/MSSS/Brian Swift/CC BY

Return to our solar system and proceed to Jupiter’s moon Io (above). In October, NASA’s Juno spacecraft flew just 7,000 miles (11,645 kilometers) above the moon’s surface, capturing this amazing image of it passing by. This is one of the best photos of Io ever taken, with enough detail to show the shadows of some of the giant volcanoes.

India’s Vikram lander lands on the moon as part of Chandrayaan-3 mission

Isro

And to our moon. On August 23, India’s Chandrayaan-3 mission landed near the moon’s south pole for the first time. This photo (above) of the Vikram lander landing on the moon was taken by the mission’s Pragyan rover a week later. The study of the moon’s south pole, initiated by Chandrayaan-3, is particularly important because of the large amount of ice there, which could help in future human exploration and the establishment of a permanent lunar base.

Comet Nishimura as seen by an amateur astronomer

Javier Zayas/Moment RF/Getty Images

Our final images become more ephemeral. Above is Comet Nishimura, which shows a striped pattern in the night sky as seen from Earth. Two rare green comets made a dramatic appearance in the sky this year. First, in early February, comet C/2022 E3 approached Earth for the first time in 50,000 years. Then, in August, amateur astronomer Hideo Nishimura discovered another comet (now named after him) that remained visible for about two months. These comets appear green because the gas surrounding their rocky core contains diatomic carbon. Diatomic carbon is a relatively rare substance consisting of a pair of bonded carbon atoms. Make the most of your images of Comet Nishimura now. The comet takes about 437 years to orbit the Sun, so it won’t be seen again until the 25th century.

Source: www.newscientist.com

Unusual extremophiles hiding in your kitchen

“May I ask what this is for?” The pharmacy assistant looks at me quizzically. I just requested some coronavirus tests, a urine sample pot, and a sterile scalpel blade. Oh, and latex gloves, please. “We want to see if there’s an extreme life form hiding inside your dishwasher,” I explain. “I see,” she said carefully, and hurried off to consult her colleague.

I admit it’s an unusual shopping list. To explain that, we have to rewind to June, when we found research on bacteria that can survive in environments that humans would consider extreme conditions, such as high temperatures, corrosive liquids, or powerful radiation. Typically, scientists head to exotic locations to find these microbes, such as the scorching hot volcanic springs of Yellowstone National Park or the frozen deserts of Antarctica. But you don’t have to go to the ends of the earth to find them, the study says. Perhaps extreme loving microbes are not only surviving, but thriving. Among the kitchen appliances.

That was it. I had to find out if my kitchen was really inhabited by microorganisms like the list of superhero powers. In the process, I gained a new appreciation for the diversity of life. And you’ll never look at a coffee machine quite the same way again.

Extremely affectionate microbes are a treasure trove for bioprospectors who explore the natural world in search of biotechnological innovations. For example, PCR tests for the coronavirus rely on a DNA copying enzyme that was first isolated from bacteria. Thermas Aquatics They live in hot springs and can withstand temperatures hot enough to poach eggs.

Source: www.newscientist.com

The Rapid Growth of Jellyfish Tentacles: A Few Days’ Transformation

New research reveals how cladoceran jellyfish can regenerate tentacles in just a few days, highlighting the role of unique stem-like proliferating cells in this rapid regeneration process. This breakthrough provides insight into similar regeneration processes in other species. Credit: SciTechDaily.com

Japanese scientists have discovered that the cladoceran jellyfish uses stem-like proliferating cells to regenerate its tentacles, providing new insights into the process of blastogenesis and its evolutionary similarities in other organisms. . seed Like a salamander.

A type of jellyfish about the size of a little fingernail cladonema Amputated tentacles can regrow in a few days, but how do they regrow? Functional tissue regeneration across species such as salamanders and insects repairs damage and grows into missing appendages It relies on its ability to form blastocytes, which are masses of undifferentiated cells. Jellyfish, like other cnidarians such as corals and sea anemones, exhibit high regenerative abilities, but how their vital blastema cells are formed has remained a mystery until now.

Japanese research team reveals that stem-like proliferating cells (actively growing and dividing but not yet differentiated into specific cell types) appear at injury sites and help form blastomas. I made it.

The results of this study were published in the journal Science on December 21st. PLOS Biology.

The jellyfish Cladonema pacificum exhibits branched tentacles that can strongly regenerate after amputation.Credit: Sou Fujita, University of Tokyo

“Importantly, these stem-like proliferating cells in the blastema are different from the resident stem cells localized in the tentacles,” said corresponding author Yuichiro Nakajima, a lecturer at the University of Tokyo’s Graduate School of Pharmaceutical Sciences. “Repair-specific proliferating cells primarily contribute to the newly formed tentacle epithelium (thin outer layer).”

According to Nakajima, the resident stem cells present in and near the tentacles are responsible for generating all cell lineages during homeostasis and regeneration, and maintain all the cells needed throughout the jellyfish’s life. means to repair. Repair-specific proliferating cells appear only upon injury.

“The combination of resident stem cells and repair-specific proliferating cells enables the rapid regeneration of functional tentacles within a few days,” Professor Nakajima said, adding that jellyfish use their tentacles to hunt and feed. he pointed out.

Resident stem cells (green) and repair-specific proliferating cells (red) contribute to the regeneration of Cladonema tentacles.Credit: Sou Fujita, University of Tokyo

According to lead author Sosuke Fujita, a postdoctoral researcher in the same laboratory as Nakajima at the Graduate School of Pharmaceutical Sciences, the discovery will help researchers understand how blastoma formation differs between different animal groups. It shows that you understand.

“In this study, our aim was to use the tentacles of the cnidarian jellyfish to address the mechanisms of blastogenesis. cladonema “As a regeneration model for non-bilateral animals, or animals that do not form bilaterally symmetrically during embryonic development,” Professor Fujita said, explaining that this study could provide insights from an evolutionary perspective.

For example, salamanders are bilaterally symmetrical animals that can regenerate limbs. Their limbs contain stem cells that are restricted to the needs of specific cell types, and this process is thought to function similarly to the repair-specific proliferating cells observed in jellyfish.

“Given that repair-specific proliferating cells are similar to restricted stem cells in the limbs of bilateral salamanders, the formation of blastema by repair-specific proliferating cells has been linked to complex organs and appendages during animal evolution. We can infer that this is a common feature that was acquired independently for organ regeneration,” said Fujita. Said.

After 72 hours of amputation, Cladonema’s regenerating tentacles are fully functional.Credit: Sou Fujita, University of Tokyo

However, the cellular origin of the repair-specific proliferating cells observed in blastema cells remains unclear, and researchers believe that the tools currently available to investigate their origin are too limited. They say they are unable to elucidate or identify other distinct stem-like cells. cell.

“It is essential to introduce genetic tools that allow tracing and intracellular manipulation of specific cell lineages. cladonema‘ said Nakajima. “Ultimately, understanding the mechanisms of blastoma formation in regenerating animals, including jellyfish, may help us identify cellular and molecular components that improve our own regenerative abilities.”

Reference: “Distinct stem-like cell populations promote functional regeneration of Cladonema medusa tentacles” by Sosuke Fujita, Mako Takahashi, Manabu Kumano, Erina Kuranaga, Masayuki Miura, and Yuichiro Nakajima, December 21, 2023. PLOS Biology.
DOI: 10.1371/journal.pbio.3002435

This research was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, the Japan Science and Technology Agency, the Japan Agency for Medical Research and Development, and a grant from the National Institute for Basic Biology Joint Research Project.

Source: scitechdaily.com

The surface of Enceladus may have significant amounts of untouched organic material

Enceladus, Saturn’s sixth-largest moon, is an interesting place to look to our solar system in the search for evidence of extraterrestrial life, given its habitable oceans and plumes that deposit organic-containing marine material on its surface. It brings you the right opportunities. Organic marine material may be sampled by the Enceladus lander mission. Considering the UV and plasma environment, it is interesting to understand the amount of relatively pure and unaltered organic matter present on the surface.

Enceladus’ tiger stripes are known to be caused by the moon’s icy interior spewing ice into space, creating a cloud of fine ice particles above the moon’s south pole, forming Saturn’s mysterious E ring. It is being This evidence comes from his NASA Cassini spacecraft, which orbited Saturn from 2004 to 2017. Shown here is a high-resolution image of Enceladus taken from a nearby airfield. The tiger stripes appear in a false blue color. Image credit: NASA / ESA / JPL / SSI / Cassini Imaging Team.

“By sending a mission to the surface of Enceladus, we can learn a lot about the biological signatures that may exist in Enceladus’ oceans,” said Amanda Hendricks, a senior scientist at the Planetary Science Institute. .

“Previously, it was thought that sampling the freshest material from Enceladus’ ocean would require flying through the plume and measuring plume particles and gas.”

“But now we know that we can land on the surface, and we are confident that the instrument can measure plume organic matter from the ocean in its relatively natural state.”

“Thanks to measurements from NASA’s Cassini spacecraft, we know that Enceladus’ ocean is habitable,” she added.

“We know that there is liquid water, energy, and chemicals such as carbon, hydrogen, nitrogen, oxygen, phosphorus, and sulfur, which are necessary for life as we know it. It is an ingredient.”

“Enceladus is an oceanic world. Beneath its icy surface is a liquid ocean.”

“There are at least some ocean worlds in our solar system, but Enceladus is special because it is spraying ocean material into space via plumes of water vapor and ice particles at its south pole. This means Cassini’s instruments were able to reveal its signature.” As the spacecraft flew through Enceladus’ plumes, the ocean was visible. ”

“Fortunately, this study found that even though some of the plume particles were ejected into the Saturn system, nearly 90% of the plume particles returned to the Moon’s surface. This is likely due to marine material containing organic matter. But it’s sitting right on the surface.”

Organic molecules found in Enceladus’ plumes include molecules such as methane and ethane, as well as more complex molecules.

Organic matter is processed or chemically transformed by charged particles such as the sun’s ultraviolet photons and electrons.

But if scientists want to know whether ocean-derived biosignatures are present in plume particles, they need these particles to be as pristine as possible and unexposed to ultraviolet light.

An artist’s impression of NASA’s Cassini spacecraft flying through a plume of smoke spewing from Enceladus’ south pole. These plumes are much like geysers, releasing a combination of water vapor, ice grains, salt, methane, and other organic molecules. Image credit: NASA/JPL-Caltech.

In the new study, Dr. Hendricks and fellow Penn State researcher Christopher House use data from NASA/ESA’s Hubble Space Telescope and Cassini to show that ultraviolet photons can be detected on Enceladus’ plume-covered surface. We estimated how deep it could penetrate.

“What we found in this study is that there are places on the surface of Enceladus where a spacecraft can land and collect samples. If we do that, we could measure organic matter in a relatively natural state.” Dr. Hendricks said.

“That’s because the sun’s ultraviolet photons don’t penetrate very deeply into the ice surface.”

“These harmful solar UV photons only penetrate about 100 micrometers into the ice surface. That’s the width of several human hairs!”

“So the topmost surface is exposed to harmful UV photons, but only some of the organic matter is chemically changed, and soon that material is covered by fresher plume material. .”

“And the deeper particles do not undergo further deformation because the ultraviolet photons are prevented from interacting with the deeper material.”

“The newly deposited plume particles act as a shield for the material below. They act like a sunscreen!”

“Ideally, we would like to someday land on the surface of Enceladus and sample organic matter from the relatively pristine ocean.”

“This result is important because the penetration depth of these harmful ultraviolet photons is so shallow that it suggests that there is a lot of relatively primitive organic matter that can be sampled.”

“Slightly deeper particles are less exposed to UV light, meaning the organic matter has a lower age of exposure.”

“Ultraviolet light easily alters organic molecules, so the depth at which such light reaches the surface of the icy world is critical,” Dr House added.

“Because the penetration depth of ultraviolet light was found to be short, our findings confirm that there is sufficient organic material trapped and preserved within Enceladus’ ice that can be traced back to its oceans. Did.”

“It’s awe-inspiring to think that we can easily obtain so much organic matter from habitable extraterrestrial oceans using known techniques.”

of findings It was published in the magazine Communication Earth and Environment.

_____

AR Hendrix & CH House. 2023. The effective UV exposure age of organic matter on Enceladus’s surface is low. common global environment 4,485; doi: 10.1038/s43247-023-01130-8

Source: www.sci.news

Achieving 99.99923% Reflectance: The Ultimate Mid-Infrared Mirror

As reported in nature communications, a collaborative international effort led to the creation of the first mid-infrared supermirror with extraordinary reflectivity. This innovation promises to significantly enhance environmental gas sensing and industrial processes, and represents a major leap forward in mirror technology.

Advanced infrared mirrors enhance climate and biofuels research through precise trace gas detection. An international research team from the United States, Austria, and Switzerland has demonstrated the first true supermirror in the mid-infrared spectral region. These mirrors are key to many applications, including optical spectroscopy for environmental sensing and laser cutting and welding for manufacturing.

Achieving near-perfect reflectance. In the field of high-performance mirrors, everyone is searching for the impossible: a perfectly reflective coating. In the visible wavelength range (i.e. between 380 nm and 700 nm), advanced metal mirrors achieve reflectivity as high as 99%. This means 1. photon 99 is lost with each reflection.

Although this may be impressive, in the near-infrared region (i.e., between approximately 780 nm and 2.5 μm), mirror coatings demonstrate a reflectance of 99.9997%, meaning that out of 1 million reflected photons, only one photon is lost. There are only three.

There has been a long-standing desire to extend the performance level of this supermirror into the mid-infrared (wavelengths from 2.5 μm to 10 μm and beyond), where it could enable advances in trace gas sensing tasks related to climate change and biofuels. Become. It can also be used in industrial applications such as laser processing and nanofabrication. So far, the best mid-infrared mirrors lose one photon to approximately 10,000 photons. This is about 33 times worse than near-infrared mirrors.

International cooperation leads to breakthroughs. As explained in the article published in nature communications, Thorlabs’ Crystalline Solutions (Santa Barbara, California), the Christian Doppler Institute for Mid-Infrared Spectroscopy at the University of Vienna (Austria), the US National Institute of Standards and Technology (NIST), and the University of Neuchâtel (Switzerland) are the first to create a truly intermediate We have demonstrated an infrared super mirror.

These mirrors lose only 8 out of 1 million photons and achieve a reflectance of 99.99923%. Achieving such extreme reflectance required a combination of mastery of materials, mirror design, and manufacturing processes.

Patterned 4-inch GaAs wafer with single-crystal GaAs/AlGaAs die. The final product is fused onto a coated silicon substrate. Credit: George Winkler A new paradigm for mirror coatings. To realize this first-generation mid-infrared (MIR) supermirror, researchers devised and demonstrated a new paradigm in coatings. They combined traditional thin-film coating techniques with new semiconductor materials and methods to overcome material limitations in the challenging mid-infrared region.

Garrett Cole, technical manager for our crystal solutions team, said: By extending this platform to longer wavelengths, our international collaboration has demonstrated for the first time a MIR coating method with less than 5 ppm of undesired absorption and scattering losses. ”

These mirrors utilize the extremely high purity and superior structural quality of molecular beam epitaxy, an advanced process used to fabricate many different semiconductor devices, to produce single-crystal GaAs/AlGaAs with negligible absorption and scattering. Produces multilayer films. This starting material is processed into high-performance mirrors using advanced microfabrication techniques, including direct “fusion” bonding onto high-quality conventional amorphous thin-film interference coatings deposited at the University of Neuchâtel.

Manufacturing these revolutionary mirrors was only half the challenge. Scientists also needed to systematically measure the mirrors to prove their superior performance. Gar-Wing Truong, principal scientist at Thorlabs Crystalline Solutions, said: “It was a huge team effort to bring together our equipment and expertise to clearly demonstrate total losses as low as 7.7ppm, six times higher than previously achieved by any of his traditional MIR coating techniques will do. ”

Co-lead author Lukas Perner, a scientist at the University of Vienna, added: Our combined efforts in innovative mirror technology and advanced characterization methods have enabled us to demonstrate superior performance and break new ground in MIR. ”

Impact on environmental sensing and spectroscopy. The immediate application of these new MIR supermirrors is to significantly improve the sensitivity of optical devices used for measuring trace gases. These devices, called cavity ring-down spectrometers (CRDS), can detect and quantify trace amounts of important environmental markers, such as carbon monoxide.

The research team turned to NIST research chemists Adam Fleischer and Michelle Bailey, who have been working on this technology for years. In a proof-of-concept experiment that put these mirrors through their paces, Fleischer and Bailey showed that the mirrors were already superior to the state-of-the-art.

“Low-loss mirrors make it possible to achieve very long optical path lengths in small devices, in this case like compressing the distance from Philadelphia to New York City to a one-meter range,” says Bailey. says Mr. “This is an important advantage for ultrasensitive spectroscopy in the mid-infrared spectral range, such as the measurement of radioisotopes important for nuclear forensics and carbon dating.”

Reference: “Mid-infrared supermirror with finesse greater than 400,000” Gar-Wing Truong, Lukas W. Perner, D. Michelle Bailey, Georg Winkler, Seth B. Cataño-Lopez, Valentin J. Wittwer, Thomas Südmeyer, Catherine Nguyen, Author David Folman, Adam J. Fleischer, Oliver H. Heckle, Garrett D. Cole, December 6, 2023, nature communications. DOI: 10.1038/s41467-023-43367-z

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ADHD Medication Errors in US Children Skyrocket with Alarming 300% Jump

Medication errors in children with ADHD have increased dramatically, with the majority occurring at home and involving males between the ages of 6 and 12, a study has found. Enhanced education and improved medication management are needed to reduce these errors. Credit: SciTechDaily.com

Experts call for patient and caregiver education and the development of improved dosing and tracking systems that are tolerable in children.

attention-deficit/hyperactivity disorder (ADHD) is one of the most common childhood neurodevelopmental disorders. In 2019, nearly 10% of children in the United States were diagnosed with ADHD. Currently, about 3.3 million children in the United States, or about 5 in 100 children, are prescribed her ADHD medication.

Increase in ADHD medication errors

In a new study recently published in the journal Pediatricsresearchers from Nationwide Children’s Hospital’s Center for Injury Research and Policy and the Central Ohio Poison Center, investigated the characteristics and characteristics of out-of-hospital ADHD medication errors reported to U.S. poison centers from 2000 to 2021 in people under age 20. We investigated trends.

According to the study, the annual number of ADHD-related medication errors increased by 299% from 2000 to 2021. During the study period, 87,691 medication error incidents involving ADHD medications as the primary substance in this age group were reported to U.S. poison centers. An average of 3,985 individuals are born per year. In 2021 alone, he was reported for 5,235 medication errors, which equates to 1 child for every 100 minutes he received. The overall trend was that males accounted for 76% of medication errors and the 6-12 year age group accounted for 67% of medication errors. Approximately 93% of exposures occurred in the home.

Common medication error scenarios

Among medication errors involving ADHD medications as the primary substance, the most common scenarios include:

  • 54% – “I accidentally took or administered my medication twice.”
  • 13% – “I accidentally took or gave someone else’s medication.”
  • 13% – “I took/administered the wrong medication.”

“The increase in the number of reported medication errors is consistent with the findings of other studies that have reported an increase in the number of ADHD diagnoses among children in the United States over the past two decades, which reflects the use of ADHD medications. “It is likely associated with an increase in

Health effects and prevention strategies

In 83% of cases, the person was not receiving treatment in a health facility. However, 2.3% of cases were admitted to a health care facility, of which 0.8% were admitted to a critical care unit. Additionally, 4.2% of cases were associated with serious medical outcomes. Some children experienced agitation, tremors, seizures, and changes in mental status. Children under 6 years of age were twice as likely to experience a serious medical outcome and more than three times as likely to be admitted to a health care facility compared to children aged 6 to 19 years.

“Because medication errors in ADHD are preventable, more attention needs to be paid to educating patients and caregivers and developing improved medication and tracking systems that are resistant to children,” said the study’s senior author. said Center Director Gary Smith, MD, PhD. Contributes to injury research and policy at Nationwide Children’s Hospital. “Another strategy could be a move away from pill bottles to unit-dose packaging, such as blister packs, which could help people remember if a drug has already been taken or administered.”

Prevention efforts should focus on the home, but additional attention should also be paid to schools and other settings where children and adolescents spend time or receive medications.

References: “Pediatric ADHD Medication Errors Reported to U.S. Poison Centers from 2000 to 2021” Mikaela M. DeCoster, BS; Henry A. Spiller, MS, D.ABAT; Jaahnavi Badeti, MPH, BDS. Marcel J. Casavant, MD. Natalie I. Rein, Pharm.D., BCPS, BCCCP. Dr. Nicole L. Michaels. Motao Zhu, MD, MS, PhD. Gary A. Smith, MD, PhD, September 18, 2023; Pediatrics.
DOI: 10.1542/peds.2023-061942

Data for this study were obtained from the National Poison Data System (NPDS) maintained by the American Poison Centers (formerly the American Association of Poison Control Centers (AAPCC)). Poison Centers receive calls through the National Poison Helpline (1-800-222-1222) and document and report information to NPDS about the product, route of exposure, exposed individuals, exposure scenario, and other data.

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Photoswitches: a revolutionary way to store solar energy

Groundbreaking research has identified a molecular photoswitch that can improve solar energy storage. Researchers used quantum computing to analyze large databases to find the best molecules for the technology, taking an important step in harnessing emissions-free solar energy. Credit: SciTechDaily.com

Optimization of molecular photoswitches for solar power generation.

Molecular photoswitches that can both convert and store energy could potentially make harvesting solar energy more efficient. The research team quantum computing A method of finding molecular structures that is particularly efficient for this purpose.As the team explained in the journal Angewante ChemieTheir procedure was based on a dataset of more than 400,000 molecules that were screened to find the best molecular structures for solar energy storage materials.

MOST project: new solar energy pathways

Currently, solar energy is used directly to generate electricity or indirectly through energy stored in thermal storage. A third route could involve first storing energy from the sun in a photosensitive material and then releasing it when needed. The EU-backed project MOST (‘Molecular Solar Thermal Energy Storage’) is researching molecules such as photoswitches that can absorb and store solar energy at room temperature, in order to make the use of completely emission-free solar energy a reality. Masu.

A research team led by Kurt V. Mikkelsen of the University of Copenhagen, Denmark, and Kasper Moss Poulsen of the Polytechnic University of Barcelona-Catalunya, Spain, took a closer look at the photoswitches that are ideal for this task. They studied molecules known as bicyclic dienes, which switch to a high-energy state when exposed to light. The most prominent example of this bicyclic diene system is known as norbornadiene quadricyclane, but a vast number of similar candidates exist. The researchers explain: “The resulting chemical space consists of approximately 466,000 bicyclic dienes that we screened for potential applicability to MOST technology.”

Innovative screening methods and promising discoveries

Screening a database of this size is typically done as follows: machine learning, But this would require large amounts of training data based on real-world experiments, which the team didn’t have. Screening and evaluation of database molecules using previously developed algorithms and the new evaluation score “Eta” yielded clear results. All six of his top-scoring molecules differed from the original norbornadienequadricyclane system in important structural respects. The researchers concluded that this structural change, an enlargement of the molecular bridge between the two carbon rings of the bicyclic moiety, allowed the new molecule to store more energy than the original norbornadiene.

The researchers’ work demonstrates the potential for optimizing solar energy storage molecules. However, new molecules must first be synthesized and tested under real conditions. “Even if systems can be prepared synthetically, there is no guarantee that they will be soluble in the relevant solvents and will actually photoswitch in high yields, as we envisioned with Eta, or “There is no guarantee that there will be any optical switching at all,” the authors caution.

Impact and prospects

Nevertheless, the team developed a new large-scale training data set for machine learning algorithms, shortening difficult pre-synthetic research steps for chemists working on such systems in the future. The authors envision that this much larger reservoir of bicyclic dienes could be exploited to study photoswitches for a variety of applications, making it easier to tailor molecules to specific requirements. doing.

References: “Bicycles for Molecular Solar Energy Storage Candidates” by Andreas Arbus Hillers Bentsen, Jacob Linge Erholm, Oskar Berlin Ober, Helen Herzel, Kaspar Moss Poulsen, and Kurt V. Mikkelsen. Exploring the chemical space of formula dienes”, July 25, 2023, Angewante Chemie International Edition.
DOI: 10.1002/anie.202309543

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Unraveling the Enigmatic Giant Examoon: Exploring the Cosmic Mysteries of Pandora’s Box







Document


This artist’s impression shows a gas giant exoplanet orbiting a Sun-like star, represented by Kepler-1625b. Credit: NASA

The discovery of giant exomoons around the planets Kepler-1625b and Kepler-1708b raises questions. Since the planets orbit, it is not uncommon for these exoplanets to have moons around them. This makes them even more difficult to detect. So far, only two of the more than 5,300 known exoplanets have been discovered to have moons. New data analysis shows that scientific statements are rarely black and white, that behind every result there is more or less uncertainty, and that the path to a statement often resembles a thriller. Masu.

Introduction to Exomoon research

In observations of the planets Kepler-1625b and Kepler-1708b with the Kepler and Hubble Space Telescopes, researchers discovered the first traces of such moons. New research calls these previous claims into question. Scientists from the Max Planck Institute for Solar System Research and Sonnenberg Observatory in Germany report in the same journal. natural astronomy

The “planet-only” interpretation of the observations is more definitive.

For their analysis, the researchers used Pandora, a newly developed computer algorithm that facilitates and accelerates the search for the Exum Moon. They also investigated what types of exomoons could in principle be discovered with modern space-based astronomical observations. Their answers are quite shocking.

Examoon: A rare entity in observation

In our solar system, with the exception of Mercury and Mercury, the fact that a planet orbits one or more moons is more the rule than the exception. Venus, all other planets have such companions.

For gas giants Saturn Researchers have discovered 140 natural satellites to date. Therefore, scientists believe that planets in distant star systems are also likely to have moons. But so far, there is only evidence for two such examooons: Kepler-1625b and Kepler-1708b. This low yield is not surprising. After all, distant satellites are naturally much smaller than their home world, and therefore much more difficult to find. And combing through observations of thousands of exoplanets for evidence of satellites is extremely time-consuming.

Pandora: Exomoon search algorithm

To make searching easier and faster, the authors of the new study utilize a search algorithm called Pandora that they developed and optimized for exomoon searches. They announced the method last year And the algorithm is available to all researchers as open source code. When applied to observational data from Kepler-1625b and Kepler-1708b, the results were surprising.

“We wanted to confirm the discovery of exomoons around Kepler-1625b and Kepler-1708b,” said MPS scientist Dr. Rene Heller, lead author of the new study. “However, unfortunately, our analysis shows that this is not the case,” he added.


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New Material with Ultra-High Hardness Competing with Diamond

Scientists have discovered a new type of material, carbon nitride, that may rival diamond in hardness. The discovery is the result of international collaboration and decades of research, and its durability, properties such as photoluminescence and high energy density open up a wide range of industrial applications. This breakthrough, funded by an international grant and published in Advanced Materials, represents a significant advance in materials science.

Scientists have solved a decades-old mystery and uncovered a nearly indestructible material that could rival the hardest material on Earth, diamond, a study has announced.

Researchers have shown that when carbon and nitrogen precursors are exposed to extreme heat and pressure, the material known as carbon nitride becomes harder than cubic boron nitride, the second hardest material after diamond. discovered.

Unlocking the potential of carbon nitride

This breakthrough opens the door to multifunctional materials used for industrial purposes such as protective coatings for cars and spacecraft, heavy-duty cutting tools, solar panels, and photodetectors, experts say. states.

Materials researchers have been trying to unlock the potential of carbon nitride since the 1980s, when scientists first noticed its impressive properties, including high heat resistance.

However, despite more than 30 years of research and multiple synthetic attempts, no reliable results were reported.

International cooperation leads to success

Now, an international team of scientists led by researchers from the Center for Extreme State Science at the University of Edinburgh and experts from Germany’s Bayreuth University and Sweden’s Linköping University has finally achieved a breakthrough.

The researchers heated various forms of carbon-nitrogen precursors to temperatures of more than 1,500 degrees Celsius while exposing them to pressures ranging from 70 to 135 gigapascals (about 1 million times atmospheric pressure). Celsius.

To determine the atomic configuration of compounds under these conditions, intense X-ray beams were applied to the samples at three particle accelerators: the European Synchrotron Research Facility in France, the Deutsche Electronen Synchrotron in Germany, and the Advanced Photon Source. It was irradiated. In the US.

What new discoveries mean

Researchers have discovered that three carbon nitride compounds have the necessary building blocks for superhardness.

Remarkably, all three compounds retained their diamond-like quality upon return to ambient pressure and temperature conditions.

Further calculations and experiments suggest that this new material contains additional properties such as photoluminescence and a high energy density that allows it to store large amounts of energy in a small amount of mass.

The potential applications for these ultra-incompressible carbon nitrides are vast, researchers say, and could position them as the ultimate engineering material, rivaling diamond.

The research, published in Advanced Materials, was funded by the UKRI FLF scheme and a European research grant.

Dr Dominic Lanier, Future Leaders Fellow at the Institute for Condensed Matter Physics and Complex Systems, School of Physics and Astronomy, University of Edinburgh, said: Materials researchers have been dreaming for the past 30 years. These materials provide a strong motivation to bridge the gap between high-pressure material synthesis and industrial applications. ”

Dr Florian Tribel, Assistant Professor at the Department of Physics, Chemistry and Biology at Linköping University, said: “These materials are not only outstanding in their multifunctionality, but also in technically suitable phases, a situation that has been observed thousands of kilometers deep within the Earth’s interior. This collaboration opens new possibilities for this field. I strongly believe that it will open up new possibilities.”

Reference: “Synthesis of ultraincompressible and recoverable carbon nitride featuring CN4 tetrahedra”, Dominique Laniel, Florian Trybel, Andrey Aslandukov, Saiana Khandarkhaeva, Timofey Fedotenko, Yuqing ying, Nobuyoshi Miyajima, Ferenc Tasnádi, Alena By V. Ponomareva, Nityasagar Jena, Fariia Iasmin Akbar, Bjorn Winkler, Adrian Neri, Stella Chariton, Vitali Plakapenka, Victor Millman, Wolfgang Schnigg, Alexander N. Rudenko, Mikhail I. Katsnelson , Igor A. Abrikosov, Leonid Dubrobinsky, Natalia Dubrobinskaya, October 11, 2023, advanced materials.
DOI: 10.1002/adma.202308030

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Decoding the key to aging well with medaka fish

A study of killifish by the Max Planck Institute revealed that older fish enter a state of starvation due to changes in their adipose tissue. Activating a specific subunit of AMP kinase restores health and longevity in humans, suggesting a new way to promote healthier aging in humans.

Genetic switch rescues aging fish from starvation trap.

Fasting interventions that alternate between fasting and refeeding are generally thought to improve health. However, these interventions do not work well in older animals.

The question is, why?

By studying short-lived killifish, researchers at the Max Planck Institute for the Biology of Aging in Cologne found that older fish deviate from the fasting and refeeding cycles of their youth, and even when they consume food, they permanently It was shown that the body enters a state of fasting. However, the benefits of post-fasting refeeding in old medaka fish can be restored by genetically activating specific subunits of AMP kinase, an important sensor of cellular energy.

These mutant fish experience improved health and longevity and require both fasting and refeeding to provide health benefits, which have been shown to act through AMP kinase. I am.

Medaka ages rapidly. The bright colors of their youth fade in just a few months.Credit: K. Link / Max Planck Institute for the Biology of Aging

It has already been shown in many model organisms that reducing food intake through calorie restriction or periods of fasting has positive effects on health. However, it is difficult for humans to reduce the amount they eat throughout their lifetime. To find the optimal timing for fasting, researchers introduced fasting interventions at different ages, but found that these interventions in older adults did not provide the same benefits as in younger animals.

A research team in Cologne, Germany, now investigated the effects of age-related fasting on medaka fish. Medaka is a rapidly aging fish that grows from young to old in just a few months. The researchers either starved young and old fish for several days or fed them twice a day. They found that the visceral adipose (adipose) tissue of older fish became less responsive to feeding. “Adipose tissue is known to respond most strongly to changes in food intake and plays an important role in metabolism, which is why we looked at it more closely,” said lead author of the study. explains Roberto Ripa.

It is important to alternate between fasting and meals

The researchers found that, unable to respond to the feeding phase, the adipose tissue of old fish enters a permanent state of starvation, where energy metabolism ceases, protein production decreases, and tissue does not renew. “We thought that older fish would be unable to switch to fasting after feeding. Surprisingly, the opposite was true, and older fish would be unable to switch to fasting after feeding. , they were in a state of permanent starvation,” said study leader Adam Antebi, director of the Max Planck Institute for the Biology of Aging.

Permanently fasted adipose tissue

When the researchers looked more closely at how the fat tissue of old fish differs from that of young fish, they discovered a specific protein called AMP kinase. This kinase is a cellular energy sensor and is composed of various subunits, among which the activity of the γ1 subunit decreases with age. When scientists genetically engineered this subunit to increase its activity, the starvation-like state was overcome, and the old fish became healthier and lived longer.

human aging

Interestingly, an association was also found between the γ1 subunit and human aging. Significantly lower levels of certain subunits were measured in samples from older patients. Additionally, in human samples, we were able to show that people who are less frail at older ages have higher levels of the γ1 subunit.

“Of course, we still don’t know whether the human γ1 subunit is actually involved in healthy aging. The next step is to find a molecule that precisely activates this subunit and use it to “We investigate whether this can have a positive impact on aging,” explains Adam Antebi.

Reference: “Refeeding related AMPK”γ1 Complex activity is a hallmark of health and longevity.” Roberto Ripa, Eugen Barrissa, Joachim D. Steiner, Raymond Lavoie, Andrea Annibal, Nadine Hocher, Christian Razza, Luca Dolfi, Chiara Calabrese, By Anna M. Meyer, Maria Cristina Polidori, and Roman – Ulrich Müller and Adam Antebi, November 13, 2023, natural aging.
DOI: 10.1038/s43587-023-00521-y

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Researchers Discover the Root Cause of a Historic, Lethal Climate Shift Millions of Years in the Past

Scientists have linked mass extinctions and climate change over the past 260 million years to massive volcanic eruptions and Earth’s astronomical cycles. The study highlights the role of CO2 emissions in climate change and reveals a complex relationship between Earth’s geology and position in space that is distinct from modern anthropogenic climate change.

New research reveals that Earth’s geological history is tied not only to the planet’s interior, but also to its astronomical movements.

The team of scientists concluded that it has occurred over the past 260 million years and that the mass extinction of life caused during these periods was primarily caused by large-scale volcanic eruptions and the resulting environmental crisis.

The analysis published in the magazine earth science reviews indicate that these eruptions released large amounts of carbon dioxide into the Earth’s atmosphere, resulting in extreme greenhouse climate warming and creating lethal or deadly conditions on Earth.

Astronomical cycles and Earth’s climate

Importantly, these phenomena occur every 26 to 33 million years and coincide with significant changes in the orbits of the solar system’s planets, which follow the same periodic pattern, the researchers added.

“Earth’s geological processes, long thought to be strictly determined by events inside the planet, may actually be controlled by the solar system and Earth’s astronomical cycles. milky way Galaxy,” says Professor Michael Lampino. new york university Department of Biology and senior author of the paper. “Importantly, these forces have converged many times in Earth’s past to predict dramatic changes in climate.”

The researchers, including Ken Caldeira of the Carnegie Institution for Science and geologist Sederia Rodriguez of Barnard College, say their conclusions are unrelated to climate change in the 20th and 21st centuries, and that scientists believe that human It warns that it shows that it is caused by activity. The last studied pulse of volcanic eruptions occurred about 16 million years ago.

But they added that the analysis nevertheless supports the well-established impact of carbon dioxide emissions on climate warming.

Volcanic eruptions and geological phenomena

Researchers have identified Continental Flood Basalt (CFB) eruptions, the largest volcanic eruptions on Earth with lava flows covering nearly 500,000 square miles, and other major geological events over the past 260 million years. focused. These include ocean anoxic events (periods during which the Earth’s oceans are depleted of oxygen, thereby producing toxic water) and the hyperthermal climate pulse, a sudden increase in global temperature and the resulting ocean and periods of mass extinction of non-marine life. .

They found that CFB eruptions frequently coincided with these other deadly geological phenomena, revealing the larger impact of volcanic activity. Its relevance to astronomy is evidenced by its regular, multimillion-year cycles of volcanic activity and extreme weather events, and its similarities with the known orbital periods of the Earth in our solar system and Milky Way galaxy.

The authors found that the correspondence between geological and astrophysical cycles was too close to be a mere coincidence. The big problem they were left with was how The astronomical movements of the planets disrupt the geological engines inside the Earth.

“This is an unexpected connection and predicts a convergence of both astronomy and geology. Events that occur on Earth occur within the context of our astronomical environment,” Rampino said. Observe.

References: “Periods of ~32.5 My and ~26.2 My in correlated episodes of continental flood basalts (CFBs), hyperthermal climate pulses, anoxic oceans, and mass extinctions over the past 260 My years: geological and astronomical cycles. Relationships” by Michael R. Rampino, Ken Caldeira, and Cederia Rodriguez, September 25, 2023. earth science reviews. DOI: 10.1016/j.earscirev.2023.104548

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Harvard University debuts the world’s first logical quantum processor

Researchers at Harvard University have achieved a significant milestone in quantum computing by developing a programmable logic quantum processor that can encode 48 logic qubits and perform hundreds of logic gate operations. Hailed as a potential turning point in the field, this advance marks the first demonstration of large-scale algorithm execution on an error-correcting quantum computer.

Harvard University’s breakthrough quantum computing features a new logical quantum processor with 48 logical qubits, enabling the execution of large-scale algorithms on error-corrected systems. The development, led by Mikhail Lukin, represents a major advance towards practical fault-tolerant quantum computers.

In quantum computing, a quantum bit or “qubit” is a unit of information, similar to a binary bit in classical computing. For more than two decades, physicists and engineers have shown the world that quantum computing is possible in principle by manipulating quantum particles such as atoms, ions, and photons to create physical qubits. I did.

But exploiting the strangeness of quantum mechanics for calculations is more complicated than collecting enough physical qubits, which are inherently unstable and prone to collapsing from their quantum states.

Logical qubit: the building block of quantum computing

The real coin of the realm in useful quantum computing are so-called logical qubits. This is a bunch of redundant, error-corrected physical qubits that can store information for use in quantum algorithms. Creating logical qubits as controllable units like classical bits is a fundamental hurdle for the field, and until quantum computers can reliably run on logical qubits, , it is generally accepted that the technology cannot really take off. To date, the best computing systems have demonstrated either: two logical qubits and one quantum gate operation – similar to just one operation code unit – between them.

A team led by quantum expert Mikhail Lukin (right) has achieved a breakthrough in quantum computing. Dr. Dorev Brufstein was a student in Lukin’s lab and the lead author of the paper.

Credit: Jon Chase/Harvard University Staff Photographer

Breakthrough in quantum computing at Harvard University

A team from Harvard University led by co-director Mikhail Lukin, Joshua and Beth Friedman Professor of Physics. Harvard Quantum Initiative has achieved an important milestone in the quest for stable and scalable quantum computing. For the first time, the team has created a programmable logic quantum processor that can encode up to 48 logic qubits and perform hundreds of logic gate operations. Their system is the first demonstration of large-scale algorithm execution on an error-corrected quantum computer, and heralds the early days of fault-tolerant, or guaranteed uninterruptible, quantum computing.

was announced on Nature, this research was conducted in collaboration with Marcus Greiner, the George Basmer Leverett Professor of Physics.colleague from Massachusetts Institute of Technology; and based in Boston QuEra Computing, a company founded on technology from Harvard University’s research labs.

Harvard University’s Office of Technology Development recently entered into a licensing agreement with QuEra for a patent portfolio based on innovations developed at the Lukin Group.

Lukin called the achievement a potential inflection point similar to the early days of the field of artificial intelligence, where long-theorized ideas of quantum error correction and fault tolerance are beginning to come to fruition.

“I think this is one of those moments where it’s clear that something very special is going to happen,” Lukin said. “While there are still challenges ahead, we expect this new advance to greatly accelerate progress toward large-scale, useful quantum computers.”

This breakthrough is based on several years of research into “quantum computing architectures.” neutral atomic arrangement, pioneered in Lukin’s lab and now commercialized by QuEra. The main component of the system is a block of ultracold, suspended rubidium atoms in which the atoms (the system’s physical qubits) move around and connect, or “entangle”, into pairs during calculations. Entangled pairs of atoms form gates, units of computational power.

Previously, the team demonstrated Low error rate for entanglement operations proving the credibility of their neutrality atom array system.

Impact and future directions

“This breakthrough is a masterpiece of quantum engineering and quantum design,” said Dennis Caldwell, acting deputy director of the National Science Foundation’s Mathematics and Physical Sciences Directorate, which supported the research through NSF’s Physics Frontiers Center and Quantum Leap Challenge Institute programs. says. “By using neutral atoms, the team has not only accelerated the development of quantum information processing, but also opened new doors to the search for large-scale logical qubit devices that could have transformative benefits for science and society as a whole. I opened the door.

Researchers are now using logic quantum processors to demonstrate parallel multiplexed control of entire patches of logic qubits using lasers. This result is more efficient and scalable than controlling individual physical qubits.

“We are seeking to mark a transition in the field by starting to test algorithms that use error-corrected qubits instead of physical qubits, enabling a path to larger devices. ,” said lead author Dorev Brubstein of the Griffin School of Arts and Sciences student in Lukin’s lab.

The team continues to work on demonstrating more types of operations with 48 logical qubits and configuring the system to run continuously, as opposed to manual cycles as it currently does.

Reference: “Logical quantum processors based on reconfigurable atomic arrays” Dolev Bluvstein, Simon J. Evered, Alexandra A. Geim, Sophie H. Li, Hengyun Zhou, Tom Manovitz, Sepehr Ebadi, Madelyn Cain, Marcin Kalinowski, Dominik Hangleiter, J. Pablo Bonilla Ataydes, Nishad Mascara, Iris Kong, Xun Gao, Pedro Salles Rodríguez, Tomas Karoliszyn, Julia Semeghini, Michael J. Galans, Markus Greiner, Vladan Vretić, Mikhail D. Lukin, December 6, 2023, Nature.
DOI: 10.1038/s41586-023-06927-3

This research was supported by the Defense Advanced Research Projects Agency through the Noisy Medium-Scale Quantum Devices Optimization Program. The Ultracold Atom Center, a National Science Foundation Physics Frontier Center. Army Research Office. and QuEra computing.

Source: scitechdaily.com

Researchers uncover connection between finance and topology

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Recent research reveals a new approach that exploits persistent homology to improve stock market volatility prediction. This method has improved the accuracy of various predictive models and has significantly advanced topology and financial integration. Credit: SciTechDaily.com

In a new study published in Journal of Finance and Data Scienceresearchers at Han University of Applied Sciences International School of Business in the Netherlands, have introduced topological tail dependence theory, a new methodology for predicting stock market volatility during turbulence.

“This research bridges the gap between the abstract field of topology and the real world of finance. What’s really interesting is that this combination will help us better understand and predict stock market behavior during turbulent times. “We now have a powerful tool to do this,” said Hugo Gobat-Souto, sole author of the study.

Since the difference in the average distance of normalized stock returns for two different periods is higher than the average distance in normal times than in the preceding and subsequent periods, defining a threshold to be used in normal times can help reduce the difference in periods of financial turmoil. can be used as an indicator to predict. A turbulent time. Nevertheless, a problem with this approach is the fact that the average distance of normalized price returns suffers from the curse of dimensionality and cannot detect nonlinear and complex relationships in the data. The curse of dimensionality that the average distance of normalized stock returns suffers from is that the number of dimensions (stocks in this case) tends to be infinite, so the distance between any point (say A and B) and the other The distance between points (such as A and C) approaches 1. As a result, the average distance becomes meaningless. On the other hand, his implementation of PH information via Persistent Landscape’s WD or L^n norm does not have these problems. Therefore, this is the reason for the successful introduction of PH information in recent studies and the selection of PH information in this study. Above is his 3D scatter plot from December 16, 2019 to January 16, 2020 (regular period). Credit: Hugo Gobato Souto

Enhance financial forecasting with persistent homology

By incorporating persistent homology (PH) information through empirical testing, Souto Accuracy Leveraging nonlinear and neural network models to predict stock market volatility during turbulent periods.

3D scatter plot from January 17, 2020 to February 19, 2020 (first period). Credit: Hugo Gobato Souto

“These findings signal a major shift in the world of financial forecasting, providing more reliable tools for investors, financial institutions and economists,” Sout added.

In particular, this approach avoids dimensionality barriers and is particularly useful for detecting complex correlations and nonlinear patterns that are often difficult with traditional methods.

“It was interesting to observe that forecast accuracy consistently improved, especially during the 2020 crisis,” Souto said.

3D scatter plot from February 20, 2020 to March 23, 2020 (turbulent period) Credit: Hugo Gobato Souto

Broad implications and future directions

The findings are not limited to one particular type of model. It spans a variety of models, from linear models to nonlinear models and even advanced neural network models. These discoveries open the door to improved overall financial forecasting.

“This discovery confirms the validity of the theory and encourages the scientific community to delve deeper into this exciting new intersection of mathematics and finance,” Souto concluded.

References: “Topological tail dependence: Evidence from forecasting realized volatility” by Hugo Gobato Souto, October 14, 2023. Journal of Finance and Data Science.
DOI: 10.1016/j.jfds.2023.100107

Source: scitechdaily.com