Astronomers Unveil Moon Concealed in Earth’s Shadow

Astronomers have identified a peculiar “moon” that casts a shadow on Earth as it navigates through space. Dubbed quasi-moons, these entities don’t orbit our planet in a traditional manner, yet they maintain proximity as they travel around the sun.

According to a new study published in the American Astronomical Society Research Notes, this space rock may have been a companion to Earth for as long as 60 years.

The object, identified as 2025 PN7, is small enough that it might have evaded earlier detections. While its exact dimensions remain uncertain, researchers estimate it to be around 30 meters (98 feet) in diameter—approximately the wingspan of a typical short-haul airliner—making it the tiniest known quasi-moon associated with Earth.







“With rapid technological progress, we’re identifying near-Earth objects faster than ever,” said Dr. Darren Baskill, an astronomy lecturer at the University of Sussex, in BBC Science Focus. “The sensitivity of digital cameras has improved, allowing us to detect these faint objects, and computers can effectively process vast data sets.”

At its closest approach, this object comes within 300,000 km (186,400 miles) of Earth. Usually, it remains about 384,000 km (238,600 miles) away, but its horseshoe-shaped orbit can take it as far as 297 million km (185 million miles) from our planet.

Consequently, it’s only detectable when nearby, as occurred in August 2025, when researchers from Spain’s Complutense University of Madrid spotted it from the PanSTARRS Observatory in Hawaii.

Upon reviewing historical records, scientists identified it as a potential Earth companion for decades.

“The primary question is, where did 2025 PN7 originate?” Baskill noted. “At its closest, 2025 PN7 will be roughly the same distance from Earth as the Moon, providing insights into the Moon’s possible origin.

“Another clue can be observed on a clear night: the Moon is full of craters. Each impact casts debris into the atmosphere, and some material may escape the Moon’s gravity and be launched into space.”

Moon’s craters offer clues to the origin of space rocks – Photo credit: Getty

Another hypothesis suggests that the space rock originated in the asteroid belt, but Baskill states, “It’s challenging to gather sufficient light from such a moving object to determine its chemical composition and origin.”

He further added, “Astronomers must be patient and wait to observe PN7 when it’s at its brightest, closest to Earth.”

2025 PN7 is just one of seven quasi-satellites currently orbiting near Earth. The other is the space rock Kamooarewa, which is the target of China’s Tianwen-2 mission. Launched in May 2025, Tianwen-2 aims to collect samples from asteroids to understand more about Earth’s origins and asteroid formation.

“These near-Earth objects, due to their occasional close passes, might become prime targets for the inaugural mining operations beyond Earth, or even enter Earth’s atmosphere,” Baskill remarked.

PN7 will remain in existence until 2085 when it will be pulled from orbit by gravitational forces.

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Source: www.sciencefocus.com

Fossils of Carnivorous “Swamp Creature” Unearthed in Brazil

Paleontologists have unearthed the fossilized lower right canine tooth of a significant proborchiid Sparathodont in Brazil’s Taubaté Basin.



The lower right canine tooth of a large proborchiid sparasodont excavated from the Tremembé Formation in Brazil. Scale bar – 5 mm inches (AE) and 20 mm inches (H). Image credit: Rangel et al., doi: 10.4072/rbp.2025.2.0534.

The newly discovered fossils date back to the Oligocene Desedan period, approximately 29 to 21 million years ago.

This specimen has been classified as a yet unnamed member of the Proborhyaenidae, an extinct family of South American mammals within the Metatherian order of Sparassodonta.

These creatures played the role of carnivorous predators on the Cenozoic continents.

“Sparassodonta represents an extinct clade of metatherians exclusive to South America, which served as the primary predator of terrestrial mammals on this continent throughout the Cenozoic era,” noted paleontologist Dr. Caio César Rangel from the Federal University of Uberlandia and the Federal University of Pernambuco and colleagues.

“Their evolutionary journey included two significant diversification events, first during the Eocene and later in the Miocene.”

“The Oligocene is marked by cooler temperatures compared to the late Eocene and Miocene.”

“This global cooling trend led to substantial environmental changes, resulting in a turnover in fauna across South America, including both extinctions and diversifications among various Metatherian clades.”



Reconstruction of Thylacosmilus atrochus, a type of post-saber-toothed beast that is part of the sister lineage to the Proborhyaenidae. Image credit: Roman Uchytel.

Paleontologists retrieved the new specimen, measuring 5.73 centimeters (2.3 inches) in length, from the lower section of the Tremembé Formation in São Paulo state, eastern Brazil.

The researchers explained, “The Taubate Basin is situated in São Paulo in southeastern Brazil, stretching from the city of Cachoeira Paulista to Jacarei.”

“It measures approximately 150 km (93 miles) in length and 10–20 km (6–12 miles) in width and lies within a rift between the Serra do Mar and Serra da Mantiqueira mountains.”

“The Tremembé Formation is the sole Late Oligocene fossil site in Brazil that preserves a diverse array of mammalian fossils and native species,” they added.

“The fauna within this area includes representatives from Metatheria, Pteroptera, Rodentia, Singleta, Astrapoteria, Litopterna, Notungulata, and Pyrotheria.”

This ancient predator thrived in wetland and lake environments and is believed to have held the position of apex predator.

The researchers noted, “The observable wear on the crown and the associated undulations found on the canines indicate that their frequent use is likely related to the capture or active processing of prey by adult specimens.”

This discovery broadens the geographic distribution of Proborhyaenidae and marks the second record of this member of the Sparasodontidae in Brazil.

“This record enhances the diversity of large mammals found in the Tremembé Formation,” the authors stated.

“In general, this region serves as a crucial geological and paleontological resource that offers valuable insights into the final phases of the Paleogene period in tropical South America.”

For more about this discovery, refer to the published paper in the August 2025 issue of Revista Brasileira de Paleontology.

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CC Rangel et al. 2025. The “swamp monster” of the Tremembé Formation (Taubaté Basin, Brazil, late Oligocene): description of a carnivorous metatherian (Sparasodonta, Proborhyaenidae). Revista Brasileira de Paleontology 28 (2): e20250534; doi: 10.4072/rbp.2025.2.0534

Source: www.sci.news

Revolutionary ‘Aging Atlas’ Uncovers Organ Changes Throughout Life Span

The visible signs of aging, like wrinkles, gray hair, and joint discomfort, are merely surface reflections of more intricate processes happening within our cells. Deep inside your body, every organ experiences its own subtle molecular shifts as you grow older.

Researchers have now developed the most detailed map to date illustrating how this process unfolds.

For further insights into our findings, which are based on data from over 15,000 samples, please visit this preprint research. The paper, currently awaiting peer review, offers an unprecedented view of how aging modifies our genomic blueprint from head to toe.







A collaborative effort among researchers worldwide has led to the creation of a comprehensive “aging atlas” that maps DNA methylation (chemical tags that regulate gene activity) across 17 different types of human tissues while tracking age-related changes.

“DNA methylation, simply put, is a chemical modification on DNA,” said Dr. Jesse Poganic, co-author of the study and a medical instructor at Harvard Medical School, as reported by BBC Science Focus.

“At a fundamental level, their primary role is to regulate which genes are activated and which are not.”

If you stretched all the DNA in your body, it would span over 300 times the distance from Earth to the sun and back – Photo credit: Getty

Despite a few mutations, each cell shares essentially the same genetic information in the form of its genome. So how do lung cells recognize their identity while stomach cells act as stomach cells? This is where methylation plays a crucial role.

“The methylation or unmethylation status at a specific point on the genome determines whether a particular gene is turned on or off,” Poganik noted.

But what does all this reveal about the aging process?

DNA methylation serves as one of the body’s essential epigenetic mechanisms, acting as a molecular switch that toggles genes on or off without altering the DNA sequence itself. By adding and removing tiny molecules known as methyl groups, cells can adjust which genes are expressed in response to diet, exercise, infections, and other environmental influences.

As time passes, these methylation patterns alter in specific ways, forming the basis of the so-called epigenetic clock, which serves as a molecular measure of biological age. Until now, most of these clocks relied on blood samples, leaving scientists uncertain if other organs followed similar patterns.

“DNA methylation patterns differ from tissue to tissue. They are specific to both the tissue and the cell type,” said Professor Nir Eynon, the study’s senior author and research group leader at Monash University, as reported by BBC Science Focus. “Thus, blood measurements don’t necessarily represent what happens in your liver, muscles, or brain.”

This gap prompted the team to gather all publicly available datasets on methylation within reach, complemented by new data from global collaborators.

The analysis covered nearly 1 million points across the genome, encompassing 17 organs, from the brain and heart to the skin, liver, stomach, and retina.

Atlas of Aging

The researchers discovered that the proportion of genomes with methylation tags varied significantly across tissues, ranging from approximately 38 percent in the cervix to over 60 percent in the retina. Surprisingly, age-related changes were quite uniform, with most tissues becoming increasingly hypermethylated as they age, resulting in more tagged DNA sites and the silencing of certain genes.

However, two organs defied this trend. Both skeletal muscle and lung tissue can experience a loss of methyl tags over time, leading to excessive or irregular gene expression.

“Most tissues show hypermethylation with age,” explained Dr. Max Jack, the study’s lead author. BBC Science Focus via email. “Yet when you refine it down to methylation rates, distinct tissue-specific patterns emerge.”

Different organs age at varying rates. An aging atlas begins to elucidate why – Credit: Getty

For instance, adipose tissue predominantly shifts toward hypermethylation, while changes are more balanced in the brain. These patterns may illuminate how different organs react to common aging stressors, such as inflammation, according to Jacques.

Overall, significantly age-related methylation changes were observed in brain, liver, and lung tissues, with skin and colon tissues also showing marked alterations. Conversely, pancreatic, retinal, and prostate tissues exhibited the least detectable age-related changes, possibly due to limited data or greater resilience to aging.

Correlation, Not Causation (For Now)

At first glance, the data imply that some organs age quicker than others. However, researchers caution that these distinctions cannot yet be interpreted as a direct rate of aging.

This is partly due to statistical factors. Some organs represent thousands of samples, while others are represented by only a handful.

Moreover, “We know that methylation changes occur as we age,” Poganik states. “What we don’t know is the extent to which they contribute to aging.”

In other words, while scientists are aware of the methylation alterations linked to aging, it’s still unclear whether those changes induce aging or whether aging triggers those changes.

Poganik believes that alterations in methylation likely account for at least some of the observable phenomena associated with aging. “Even cautious scientists would suggest there’s an element of causation,” he remarks.

The allure of this new atlas lies in its revelation of common molecular themes threading throughout the body, he adds.

“One of the most compelling aspects of this study is that it demonstrates some universality in the aging process. When we analyze various tissues, we encounter numerous similar methylation changes, suggesting a universal quality to aging.”

Nevertheless, he warns that not all alterations are causal. With so many ongoing methylation changes, some are almost certainly part of aging, while others may not hold significance.

Old atlases might not pinpoint which changes are critical and which are not, but they offer an invaluable collection of data for researchers to delve deeper into the issue than ever before. The atlas is now openly accessible through an online portal for other scientists to explore and utilize.

“We have consistently prioritized open-source research,” Jack states. “With this, we aim to make it accessible to everyone, not only to advance research but also to foster collaboration.”

Going forward, the research team plans to examine some universal associations prevalent across all tissues as we age, alongside other biomarkers that may be influencing the aging process.

“Advancements in aging pale in comparison to those in cancer,” Poganik adds. With the assistance of this atlas, scientists may finally bridge that gap.

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Source: www.sciencefocus.com

New DNA Evidence Uncovers the True Reasons Behind Napoleon’s Army Defeat

Researchers have uncovered new DNA evidence that challenges established theories regarding Napoleon’s ill-fated 1812 invasion of Russia. As his Grand Army, comprising around 500,000 soldiers, advanced toward Moscow, it encountered severe resistance, dwindling resources, and the harshness of winter.

As the troops began their retreat, starvation and disease were rampant. Analyzing the remains of soldiers now indicates that multiple infectious diseases may have caused the significant loss of life in the French emperor’s army, rather than typhus being the singular primary cause of devastation.

A recent study led by Dr. Nicholas Raskovan at the Pasteur Institute in Paris involved extracting genetic material from the teeth of 13 soldiers interred in a mass grave in Vilnius, Lithuania.

Through ancient DNA sequencing, no evidence of typhus was identified. Instead of the long-suspected bacteria rickettsia, the team pinpointed two distinct pathogens: salmonella enterica, which causes enteric fever (like typhoid), and Borrelia recurrentis, linked to recurring fever.

Raskovan mentioned, “Our research alters the understanding of pathogens previously unrecognized,” as reported in BBC Science Focus.

Previous research employed PCR tests, akin to those used in contemporary COVID-19 testing, to search solely for specific microorganisms. Currently available technology enables scientists to “cast a wider net,” allowing them to detect DNA fragments from all microorganisms present, Raskovan explained.

“Thanks to advancements in technology, we now have insights that were unimaginable a decade ago,” Raskovan noted.

“When we integrate our prior and current research, we discover that four different diseases affected just a small group of individuals. This implies that a single pathogen didn’t account for all the 3,000 deaths, but rather, these individuals were infected with various pathogens.”

The DNA extracted from these teeth was analyzed using cutting-edge technology to identify pathogens, even in trace amounts. Credit: © European Commission / Claudio Centonze

In essence, the situation for Napoleon’s army during their retreat from Russia was dire, facilitating the spread of various diseases. It was almost inevitable that if one illness was avoided, another would take hold.

The research also highlighted the strain Borrelia recurrentis found at the site, which is genetically identical to those from Iron Age Britain, approximately 2,000 years ago, a lineage that has since vanished.

Raskovan stated, “This strain derives from an ancestor that either no longer exists or is currently unknown. This emphasizes the significant changes in sanitation over the past two centuries, particularly with the advent of antibiotics that have virtually eradicated this once prevalent disease.”

For Raskovan, these ancient microorganisms are more than peculiar findings; they are historical witnesses. “For those infected, it’s not surprising,” he remarked. “For me, it’s fulfilling to reconstruct history.”

“These pathogens provide us with a means to learn about past populations and their dynamics.”

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Source: www.sciencefocus.com

Unraveling the Genetics of Fibromyalgia: New Insights into Its Causes

Individuals with fibromyalgia exhibit different genetic mutations compared to those who do not have fibromyalgia.

Katerina Conn/Science Photo Library/Getty Images

Recent advances in our understanding of the genetics behind fibromyalgia, a poorly understood disorder characterized by widespread chronic pain, are emerging. Two large-scale studies have reinforced the notion that dysfunctions within the central nervous system significantly contribute to fibromyalgia. Nonetheless, other studies have indicated the involvement of alternative mechanisms such as autoimmunity, highlighting the complex, multi-faceted nature of this ailment.

Fibromyalgia is believed to impact 2-3% of the population. While the exact cause remains a mystery, treatment is challenging. A prevailing hypothesis suggests that individuals with fibromyalgia may experience alterations in how their central nervous system interprets pain signals, potentially triggered by infections or changes in gut microbiota.

To investigate the genetics involved, two research teams undertook genome-wide association studies (GWAS) to pinpoint genetic variations prevalent in fibromyalgia patients. Their focus rested primarily on single-letter mutations rather than more extensive genomic alterations which might have more pronounced effects.

The first study, led by Michael Weinberg at Mount Sinai Hospital in Toronto, Canada, encompassed participants from various countries, including the United States, the United Kingdom, and Finland. This team gathered data from 54,629 individuals with fibromyalgia, primarily of European descent, and compared it to 2,509,126 individuals without the condition. Their findings revealed 26 genetic mutations linked to a higher risk of fibromyalgia.

Meanwhile, Joel Gelernter from Yale School of Medicine directed a second study utilizing datasets from the U.S. and the U.K. Their research involved 85,139 patients with fibromyalgia and 1,642,433 controls of mixed European, Latin American, and African ancestries. They identified 10 mutations associated with fibromyalgia among the European group, one in the African group, and 12 across diverse ancestries.

Both Weinberg and Gelernter opted not to give interviews as their studies await peer review.

“Both studies are truly commendable in terms of their participant numbers,” remarked Cindy Bohr from Erasmus Medical Center in Rotterdam, Netherlands.

In Weinberg’s study, the strongest association was linked to a variant of a gene called huntingtin, known for its role in causing Huntington’s disease. This condition results from repeating genetic sequences that prompt the production of faulty proteins. Conversely, the mutations associated with fibromyalgia are characterized by single-letter changes throughout the gene.

However, Bohr emphasizes that this mutation is unlikely to be the sole contributor to fibromyalgia. “It needs to be viewed alongside other risk factors and genetic elements.” There are likely thousands of contributing variants, along with external factors such as exposure to air pollution, she states. Larger studies are essential to uncover all contributing variants.

Despite certain limitations, the mutations identified by Weinberg’s team are found in genes linked to neuronal function, indicating that crucial mechanisms of fibromyalgia likely occur in the brain. Similarly, Gelernter’s research has highlighted variants previously connected to pain and neurologically related issues like post-traumatic stress disorder and depression.

These findings reaffirm a prevailing theory about fibromyalgia: “There’s a significant issue within the brain tissue,” said Bohr. Tracking these mutations may help identify key cell types, brain regions, and biochemical pathways that could become targets for future therapies. However, Bohr cautions that this is still years away unless existing drugs targeting known mechanisms prove relevant. Current treatments focus on approaches such as exercise, therapy, and antidepressants, though results are mixed.

Nevertheless, factors aside from genetics may also be influential. David Anderson and colleagues at King’s College London previously identified signs suggesting fibromyalgia may have autoimmune origins. In 2021, mice injected with antibodies from fibromyalgia patients exhibited symptoms like painful hypersensitivity and muscle weakness. Furthermore, research in September showed that these mice displayed atypical sensory responses, where nerves usually responsive to light touch began reacting to cold stimuli—mirroring the chronic pain experienced by fibromyalgia patients from non-painful stimuli, such as mildly lower temperatures.

“I firmly believe in the conclusions of our fibromyalgia research and anticipate that the findings will pivot the field’s focus toward autoantibodies [targeting the body’s tissues] and peripheral nerve cells [neurons outside of the brain and spinal cord], forming a new mechanism,” Anderson stated.

Bohr, however, points out that this recent research does not discount other theories. With rigorous statistical standards, while confident in the variants discovered and their implied mechanisms, they likely overlook many others. Gelernter and his team also detected several variants linked to autoimmune responses.

Professor Bohr characterizes this work as an essential “first step” towards understanding the roots of fibromyalgia. “What’s the pathway?” she inquires. “And is there something we can target?”

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Source: www.newscientist.com

New Insights into Why Birds Sing at Dawn

Zebra finches are commonly studied in captivity by biologists

Alamy

The morning chorus of birds has captivated poets and nature enthusiasts for centuries, yet the reasons behind this daily ritual remain unclear.

Recent experiments on zebra finches (Teniopygia guttata) indicate that even though darkness suppresses their songs, these birds experience a heightened inclination to sing at night, culminating in vocal bursts once night descends. Furthermore, the study implies that practicing their vocalization in daylight enhances their singing performance.

Satoshi Kojima and his team from the Korea Brain Research Institute in Daegu, South Korea, examined zebra finches raised in a lab with carefully controlled lighting to alter their light-dark schedules.

Initially, they postponed the bright light exposure for the finches by three hours from natural dawn. Under the fabricated darkness, the birds were awake yet silent, but once the light activated, they chirped more energetically than usual.

When the lights were turned on three hours prior to actual dawn, the finches resumed singing, although not as fervently as before.

Kojima explains that a longer delay between the birds waking and the onset of light results in a more intense dawn chorus.

“The birds remain awake in the dark before light arrives,” he notes. “Their natural inclination to sing is hindered by darkness, and this suppression amplifies their eagerness to sing, leading to a surge in singing immediately after the lights come on.”

The researchers subsequently trained the birds to pull a lever for 10 seconds of artificial light. When the simulated dawn was postponed by three hours, the birds engaged with the lever more often; conversely, when it was advanced, they used the lever less frequently.

The scientists administered Luzindole, a drug that counteracts melatonin, which is released at night and regulates awake cycles in numerous animals. Finches treated with the drug five hours before their normal light time awakened earlier and began to sing sooner than those given a saline solution.

Kojima and his colleagues also scrutinized the finches’ songs to observe alterations throughout the day. They discovered a notable shift in song structure between the first and second hours after dawn.

“Due to the lack of singing at night, the vocal motor system and song acoustic structure may experience slight degradation, but the dawn chorus rapidly restores or enhances them,” Kojima remarks.

While this research focused on a single species, Kojima believes that analogous factors could influence other birds. “Considering the simplicity of these mechanisms and their functional implications, we propose that they may underlie dawn choruses across various avian species.”

However, Diego Gil from the National Museum of Natural Sciences in Madrid, Spain, advises caution. “There are numerous differences among species regarding the how, when, and what they sing during their dawn chorus,” he says. “This diversity accounts for the 11 different hypotheses put forth to explain the phenomenon.”

Gill commended the study, noting that it demonstrates an increased inclination for birds to sing during pre-dawn hours. “If zebra finches experience extended nights without singing, they become more motivated to vocalize,” he explains. “They also indicate that these prolonged nights exceed their sleep requirements, prompting them to sing when given the chance.”

However, the study does not conclusively show that the purpose of the dawn chorus is to refine the birds’ songs, Gill adds. “Although these song structure alterations are believed to enhance the vocalization, there is no data to confirm that females favor these changes,” he notes. “The study merely suggests that songs evolve gradually over time.”

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Source: www.newscientist.com

Teen Creates Advanced Robotic Hand Using Just Lego Parts

Jared Lepola and a robotic hand crafted from LEGO Mindstorms components

Nathan Leppola

A robotic hand constructed by a 16-year-old boy and his father using Lego pieces can effectively grasp and manipulate objects, showcasing functionality akin to natural human hands.

Jared Leppola, a student at Bristol Grammar School in England, began working on this project with his father when he was just 14 years old. Nathan Leppola is affiliated with the University of Bristol.

The device utilizes concepts from leading research institutions like Pisa/IIT SoftHand, yet it is built entirely from readily available components from Lego Mindstorms, a popular series of educational kits designed for creating programmable robots.

“My father is a professor of robotics at the University of Bristol, and I was really inspired by the design of robotic hands,” Jared explains. “This motivated me to pursue it in an educational context using Lego.”

The hand operates using two motors based on tendon mechanics, and each of its four fingers is equipped with three joints. A differential mechanism made of Lego clutch gears connects the fingers, allowing them to move in unison until they contact an object and stop, mimicking human grasping behavior.

Throughout testing, the Lego hand successfully grabbed nine common household items, including plastic cups, bowls, and a stuffed toy weighing 0.8 kilograms.

When one finger is engaged, it fully closes in approximately 0.84 seconds and reopens in about 0.97 seconds. This speed is about half that of the Pisa/IIT SoftHand’s 3D-printed counterpart, which employs metal bearings. In static tests, the Lego hand could withstand loads of 5 Newtons, exert a pushing force of 6 Newtons, and deliver a closing force of 1.8 Newtons. Comparatively, the 3D-printed version can manage loads up to 8 Newtons, push with 7 Newtons, and has a closing force of 2 Newtons.

“You won’t find a better hand,” Nathan states regarding the 3D-printed alternative. “In terms of functionality, the LEGO hands are also considerably larger, with each finger measuring 145 millimeters long and 30 millimeters wide.”

While Lego Mindstorms was discontinued in 2022, Jared noted that the device can still be easily modified with a variety of Lego creations. “The way I designed the motor, you can simply take it out and replace it with a new one,” he explains.

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Source: www.newscientist.com

Study Indicates That Certain Snacks May Contribute to Winter Weight Gain

Indulging in snacks rich in saturated fats during winter can mislead your body into accumulating more fat, as noted by recent findings.

Researchers at the University of California, San Francisco (UCSF) have uncovered that the types of dietary fat we consume can affect how our bodies recognize seasonal changes.

“Our research indicates that the food you eat plays a crucial role in informing your body clock about the time of year,” stated Dr. Dan Levin, a postdoctoral fellow in neurology at UCSF, in a conversation with BBC Science Focus.

They discovered that consuming more saturated fat—found in red meat, butter, cakes, pies, and various baked goods—activates a protein named PER2, signaling your body that it’s summer and that it needs to store energy for the forthcoming colder months.

Conversely, consuming unsaturated fats (present in nuts, seeds, fatty fish, and vegetable oils) influences PER2 to make your body believe it’s winter, prompting it to utilize the energy from food.

These conclusions arose from experiments where the UCSF researchers simulated seasonal transitions by altering light and dark periods for mice.

During the experiments that mimicked spring and fall, mice were exposed to 12 hours of light daily, 20 hours during summer, and only 4 hours in winter.

As the faux winter nights extended, the mice, on a balanced diet, exhibited normal nocturnal behaviors, such as running on wheels as darkness fell.

However, the mice on a high-fat diet took longer to wake up and began their running routine much later after the artificial sunset, indicating a misalignment of their internal clock with the simulated light conditions.

The scientists then assessed the impacts of various dietary fats. Mice consuming a diet abundant in saturated fat were found to wake up several hours later than their counterparts before engaging in physical activity.

Saturated fats are solid at room temperature and are found in butter, fatty meats, and many baked goods – Credit: Getty Images

As a result, increased saturated fat consumption during these simulated winter conditions appeared to further disrupt the synchronization of the body’s internal clock with the light cycles.

Professor Levin emphasized that, despite being conducted on mice, the relationship between dietary fats and the body clock via the protein PER2 is likely relevant across different species.

“We believe that many insights gained from our mouse studies can be translated to humans,” he remarked. “I am eager to discover any disparities that may exist between species.”

How Our Bodies Prepare for Winter

For both wild animals and hunter-gatherers, adapting to seasonal changes is vital for survival, especially during prolonged, harsh winters when food is limited.

“In nature, fluctuations in water availability, light, and temperature dramatically alter the environment each season, compelling all organisms within the food chain to adjust,” noted Levine.

“For instance, one adaptation is for plants to produce more unsaturated fats, aiding their survival in cold, which causes both herbivores and carnivores to consume and store greater amounts of unsaturated fats.”

Thus, our bodies might be biologically programmed to anticipate higher intake of unsaturated fats as daylight hours shorten.

However, because we have access to the same food options throughout the year, many individuals often disregard this natural dietary shift.

We can indulge in our favorite saturated fat-laden foods year-round, but excessive consumption in the fall or winter can mislead your body clock into thinking it’s still summer.

“In modern society, foods high in saturated fats are abundantly available,” asserted lead author Professor Louis Ptacek, a UCSF neurologist, in BBC Science Focus. “Moreover, we often eat at ‘unnatural’ times due to light conditions. Generally, adhering to a consistent circadian eating schedule during daylight is healthier.”

Levin added that consuming seasonally appropriate foods might also be advantageous, suggesting a potential shift in fat sources throughout the year. However, he stated that further research is needed to validate this strategy.

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Source: www.sciencefocus.com

Potential Super Earth Found in the Habitable Zone of Gliese 251

Gliese 251 is an early red dwarf star, ranking as the 74th closest star system to our Sun.



An artistic interpretation of the Gliese 251 system. Featuring Gliese 251c (left), its host star (right), and the already discovered planet Gliese 251b (center). Image credit: Michael Marcheschi / m2design.

You can find Gliese 251 as a bright M dwarf star, located at a distance of 5.58 parsecs (18 light years) in the constellation of Gemini.

Also known as GJ 251, HD 265866, or Wolf 294, this star is believed to host at least two super-Earths, Gliese 251b and Gliese 251c.

Initially discovered in 2020, Gliese 251b has a mass of 3.85 Earth masses and completes an orbit in 14.2 days.

The newly identified exoplanet, Gliese 251c, boasts a mass of 3.84 times that of Earth and has an orbital period of 53.6 days.

“With so many exoplanets now known, discovering new ones may not seem significant,” remarked Paul Robertson, an astronomer at the University of California, Irvine.

“The exceptional aspect is that its host star is nearby, roughly 18 light-years distant. From a cosmic perspective, it’s essentially in our neighborhood.”

Gliese 251c was detected using the Habitable Zone Planet Finder (HPF), a state-of-the-art near-infrared spectrometer mounted on the Hobby-Eberly Telescope at McDonald Observatory in Texas.

This planetary signal was subsequently validated using the NEID spectrometer at Kitt Peak National Observatory in Arizona.

Corey Beard, Data Scientist at Design West Technologies, states:

“While the discovery is statistically significant, we are still assessing the state of the planet due to instrument and methodological uncertainties.”

“Direct imaging of this candidate will rely on the next generation of telescopes and community investment.”

Given Gliese 251c’s closeness to Earth, it stands out as a prime candidate for future direct imaging studies utilizing the Thirty Meter Telescope (TMT).

The TMT, with its large mirror, could potentially directly image dim exoplanets like Gliese 251c and verify the presence of water.

“TMT is anticipated to be the only telescope capable of capturing such details. These images will pertain to exoplanets,” Dr. Beard added.

“Such imaging isn’t feasible with smaller telescopes.”

The results from the research team were published in Astronomy Magazine.

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Corey Beard et al. 2025. Discovery of a nearby super-Earth candidate located in the habitable zone, suitable for direct imaging. A.J. 170, 279; doi: 10.3847/1538-3881/ae0e20

Source: www.sci.news

New Research Reveals Dynamic, Regionally Unique Communities of Late Cretaceous Dinosaurs

The most renowned mass extinction in Earth’s history occurred approximately 66 million years ago. A swift decline in environmental conditions resulted in the extinction of around 75% of species, including the most famous non-avian dinosaurs, and the eventual restoration of terrestrial ecosystems. The ongoing debate focuses on whether dinosaurs vanished abruptly while they were still diverse and thriving or whether they experienced a prolonged decline by the end of the Cretaceous.



Flynn and colleagues analyzed Alamosaurus fossils found in northwestern New Mexico, revealing that these dinosaurs, while very different, are contemporaneous with those discovered further north in Wyoming and Montana. Image credit: Natalia Jagielska.

The geological formations of northwestern New Mexico hold a concealed chapter of Earth’s history.

Paleontologist Daniel Peppe from Baylor University and his team have uncovered indications of a flourishing dinosaur ecosystem in the Kirtland Formation’s Naashoibito Formation just prior to the asteroid impact.

Utilizing high-precision dating methods, they established that the fossils in these formations range from 66.4 to 66 million years old.

“The Naashoibito dinosaur coexisted with the renowned Hell Creek species of Montana and the Dakotas,” Dr. Peppe remarked.

“They were not in decline; rather, they constituted a vibrant, diverse community.”

The discoveries in New Mexico challenge previous assumptions.

Instead of being uniform and weakened, dinosaur communities across North America were unique and thriving in their respective regions.

Through ecological and biogeographic analysis, the researchers determined that dinosaurs in western North America thrived in distinct biozones shaped by regional temperature variations, rather than geographical barriers like mountains or rivers.

“Our recent study indicates that dinosaurs were not on the brink of mass extinction,” stated Andrew Flynn, a researcher at New Mexico State University.

“They were thriving, but the asteroid impact ultimately led to their demise.”

“This contradicts the long-established notion that a gradual decline in dinosaur diversity precipitated mass extinction, making them more susceptible to extinction.”

“The asteroid impact briefly terminated the age of dinosaurs, but the ecosystem they left laid the groundwork for what followed.”

“Within 300,000 years post-extinction, mammals began to diversify rapidly, branching into new diets, body sizes, and ecological roles.”

“The same temperature-driven patterns that influenced dinosaur communities carried into the Paleocene, illustrating how climate influenced the rebirth of life following catastrophic events.”

“The surviving mammals continued to exhibit distinct northern and southern biological regions.”

“Mammals from the north and south are markedly different from each other, diverging from other mass extinctions, which tend to appear more uniform.”

Of findings posted in today’s edition of Science.

_____

Andrew G. Flynn et al.. 2025. Late-surviving neo-Mexican dinosaurs reveal Cretaceous superlative diversity and locality. Science 390 (6771): 400-404; doi: 10.1126/science.adw3282

Source: www.sci.news

Two New Edmontosaurus anectens Specimens Reveal Scale and Hoof Details

Paleontologists studied two remarkable specimens of end-Cretaceous duck-billed dinosaurs, Edmontosaurus anectens. They employed various imaging techniques to reconstruct the species’ physical appearance during its life, showcasing features such as the prominent crest over the neck and torso, a row of spikes on the tail, and the hooves covering the toes. Alongside fossilized footprints, Edmontosaurus anectens is now in my grasp.



Reconstruction of the life of Edmontosaurus anectens. Image credit: Dani Navarro.

“This marks the first time we’ve been able to capture a comprehensive and specific depiction of a large dinosaur,” stated researchers from the University of Chicago, including Professor Paul Sereno, the lead author of the study.

“The badlands of Wyoming, where this discovery occurred, serve as a unique ‘mummy zone’, promising additional surprises from fossils collected over years by a team of university undergraduates.”

Professor Sereno and colleagues utilized historical photographs and field research to outline a compact “mummy zone” in central-eastern Wyoming, home to several notable dinosaur “mummies” unearthed in the early 20th century.

They discovered two new mummies within piles of river sand: Edmontosaurus anectens — consisting of juveniles and adults — which preserved a large, continuous area of the external skin surface.

Using these specimens, they reconstructed a complete, fleshy profile of the species.

“The two specimens complemented each other exceptionally well,” Professor Sereno remarked.

“For the first time, we could visualize the entire outline rather than isolated patches.”

Paleontologists identified a continuous midline feature that begins as a fleshy crest along the neck and torso, transitioning into a row of spikes across the hips and down the tail. Each spike was identified on a single vertebra and interlocked with one another.

The lower body and tail featured the largest polygonal scales, while the majority were small, pebble-like scales just 1 to 4 millimeters in diameter, surprisingly tiny for a dinosaur exceeding 12 meters (40 feet) in length.

Wrinkles on the thorax indicate that this dinosaur had thin skin.

The hind legs of the significant “mummy” revealed the most unexpected finding: hooves.

The tips of each of the three hind legs were encased in wedge-shaped hooves with flat soles, akin to a horse’s.

Researchers utilized CT scans of the specimen’s feet and 3D images of the best-preserved footprints from the same era to accurately map the former to the latter.

Data from both sources enabled precise reconstruction of the hind paw’s appearance.

In contrast to the front feet, which made contact with the ground solely via the hooves, the hind feet featured thick heel pads behind the hooves.

“These duck-billed ‘mummies’ reveal several remarkable ‘firsts’: the oldest hooves ever found in a land vertebrate, the first ungulate reptile identified, and the first ungulate quadruped exhibiting distinct front and hind limb postures,” Professor Sereno asserted.

The team’s paper was published in today’s magazine, Science.

_____

Paul C. Sereno et al. 2025. The fleshy midline and hooves of a duck-billed dinosaur reveal a template for terrestrial clay ‘mummification.’ Science, published online October 23, 2025. doi: 10.1126/science.adw3536

Source: www.sci.news

Two Coral Species in Florida Declared ‘Functionally Extinct’

Midlers mentioned that no other Atlantic species reaches such dimensions or establishes extensive lattices.

“They are the sole species capable of creating a genuine 3D structure,” she stated.

To the north, around Miami and Broward counties, some remnants of corals exist. However, researchers believe a revival is highly improbable. Corals reproduce by emitting eggs and sperm that mingle in the water, but ocean currents hinder the movement of these reproductive cells southward, according to Canning.

While the study zooms in on Florida, the 2023 heatwave significantly affected elkhorn and staghorn corals throughout the Caribbean, as reported by external researchers.

Stacey Williams, the scientific director of ISER Caribe—a nonprofit dedicated to coral restoration—mentioned that nearly all elkhorn corals in southern Puerto Rico perished due to the extreme heat. Following that, the 2024 heat wave harmed some northern colonies that had demonstrated greater resilience. Her organization aims to “biobank coral species” by collecting living fragments.

In Florida, the 2023 heat wave jeopardized a long-term restoration effort for elkhorn and staghorn corals, including areas where coral coverage had improved after four years of focused interventions. Approximately fourfold.

The study suggests that importing heat-resistant corals from elsewhere may be the only viable option moving forward.

In the future, scientists might explore gene-editing corals to enhance their heat resistance, although this concept necessitates more research and careful examination, as noted by Midlers.

Recently, the International Union for Conservation of Nature approved further investigation into the potential of gene-editing tools to safeguard wildlife populations, a subject that generates significant bioethical debate.

“It’s a possibility being considered because everything is on the table,” Midlers remarked.

Source: www.nbcnews.com

Testosterone Boosts Sex Drive During Menopause – Could It Alleviate Other Symptoms Too?

Therapy that balances testosterone and estrogen reduces menopausal symptoms

Alamy Stock Photo

The menopause can bring a host of challenging symptoms such as mood fluctuations, difficulties in concentration, and a decline in sexual drive. Hormone replacement therapy is commonly sought to alleviate these issues, primarily focusing on restoring estrogen and progesterone levels, which drop significantly during midlife. Recent studies indicate that testosterone may also play a crucial role in managing various menopausal symptoms beyond just libido, including mood improvement and muscle retention.

While typically categorized as a male hormone, testosterone is also present in women, albeit at lower levels—approximately ten times less than in men. Dr. Sarah Glynn, a contributor to menopause treatment guidelines at the British Society of Sexual Medicine, notes that limited understanding of testosterone’s effects has hindered research in this area, but recent findings are changing that narrative. Increasing evidence highlights the hormone’s crucial role in women’s sexual health and its potential benefits for cognitive, muscular, skeletal, and urinary function.

Approximately half of a woman’s testosterone is produced by the ovaries, with the remainder being synthesized by the adrenal glands. Testosterone levels generally peak in the 20s and begin to decline gradually after age 30, with production halving by middle age. Dr. Sharon Parrish from Cornell University mentions that although this decline often coincides with menopause, it may not be a direct result of it.

We know little about the health implications of this decline, but it is evident that it can reduce sexual interest. “[Testosterone] plays a critical role in sexual function,” states Dr. Joan Pinkerton from UVA Health in Virginia, influencing factors such as sexual arousal, desire, and lubrication. Consequently, it makes sense that nearly half of menopausal and postmenopausal women experience issues with sexual desire, with a leading cause being hypoactive sexual desire disorder (HSDD)—a distressing lack of sexual fantasies or desire lasting at least six months. In a survey of 1,800 postmenopausal women in Europe, over one-third reported reduced desire and more than half indicated decreased interest in sex.

The notion that low testosterone contributes to diminished sex drive was established in the 1940s. Numerous studies have consistently shown that testosterone replacement therapy can enhance sexual function in menopausal women. For instance, a 2005 report involving 533 women who underwent hysterectomies noted that those receiving testosterone patches along with estrogen reported more satisfying sexual experiences than those on estrogen alone. A similar study in 2010 corroborated these findings with 272 menopausal participants.

In 2019, a meta-analysis encompassing over 80 studies involving 8,480 women demonstrated that testosterone treatment for postmenopausal women significantly heightened sexual desire and increased frequency of sexual satisfaction, arousal, orgasm, and overall self-esteem. This study garnered support from approximately 12 medical organizations, including the International Menopause Society, the Royal College of Obstetricians and Gynecologists, and the North American Menopause Society, which endorsed the use of testosterone for HSDD.

Testosterone enhances sex drive by interacting with brain receptors that activate the neural pathways governing desire, explains Parrish. Thus far, only four countries—Australia, New Zealand, South Africa, and the UK—have approved women-specific testosterone products. The U.S. Food and Drug Administration (FDA) has yet to approve these, citing insufficient data on potential long-term side effects. Nevertheless, Professor Parrish argues this caution is unwarranted, stating that some studies have tracked participants for years without revealing increased risks of cardiovascular, breast, or uterine issues.

“Most healthcare providers focused on menopausal women seek an FDA-approved testosterone therapy that is both safe and effective. We genuinely believe there’s an urgent need for such treatments, particularly concerning sexual health,” Pinkerton comments.

Finding the Right Balance

Women report feeling more like themselves after menopausal hormone treatment

Cavan Image/Alamy

Some medical professionals believe that testosterone therapy can extend benefits beyond just sexual health. A 2023 analysis covering seven studies found that testosterone may contribute to increased muscle mass, reduction in body fat, and improvements in insulin sensitivity and cholesterol levels. In 2024, Glynne and her team assessed hormone therapy in 510 women experiencing perimenopause and menopause who were also on estrogen. After four months, around 50% reported fewer anxiety episodes and less crying, while approximately 40% noted improvements in mood, focus, and fatigue. More than a third experienced enhanced memory and reduced irritability. “Common feedback is that women feel more like themselves—stronger and more empowered,” states Glynn.

Yet, skepticism remains. Pinkerton cautions that many of these studies lacked control groups, relying heavily on self-reports, which raises questions about whether improvements were genuinely due to testosterone or might be attributed to a placebo effect. “There’s some evidence concerning cognition, mood, muscle strength, cardiovascular health, and bone health, but the lack of substantial randomized controlled trial efficacy and safety data doesn’t justify recommendations for these issues,” Parrish remarks.

Most clinical trials combine testosterone therapy with estrogen, though some studies indicate that testosterone alone can effectively enhance sexual function. However, due to frequent side effects such as acne and excessive hair growth, it is generally not advised. Glynne prefers to prescribe estrogen initially, adding testosterone only if symptoms remain unresolved.

Experts agree that comprehensive clinical trials focusing on testosterone’s impacts beyond sexual health are urgently needed. Questions concerning optimal timing, dosage, and duration also persist, as Pinkerton highlights.

What stands out is that many current menopause treatments fall short for numerous individuals, particularly those with a history of hormone-sensitive breast cancer who are hesitant to undergo estrogen therapy due to concerns regarding potential tumor growth or recurrence. “This represents a significant gap in knowledge, and we need more data,” Glynn concludes.

Topics:

Source: www.newscientist.com

Will Criminal Self-Monitoring Systems Replace Prisons in the Future?

view from below the main corridor in Alcatraz cellhouse, a federal penitentiary that was a maximum security prison on island and housed some of the United States' most notorious prisoners.

“No wonder Scandinavia was the first country to abolish prisons…”

Walker/Getty Images

The 2020s marked a significant period for the United States, spending around $182 billion annually on incarceration. This was a unique phenomenon, as few nations matched the US in both the number of incarcerated individuals and the financial burden incurred. Similar overcrowding and inhumane conditions plagued prisons worldwide, leading to a compelling question: why not eliminate them? With the advancement of technology, monitoring and managing individuals remotely became a viable solution.

The Home Guard initiative aimed to replace conventional prisons with three core components. The first element was an ankle bracelet that tracked the prisoner’s location. The second aspect involved a harness equipped with sensors to monitor the individual’s actions and conversations. The final component activated if the terms of the sentencing were violated, such as leaving the designated area or engaging in illicit activities, deploying an energy device similar to a stun gun to temporarily incapacitate the individual. Prisoners rapidly adapted to these regulations.

It’s unsurprising that Scandinavian nations were pioneers in abolishing prisons. In the region, imprisonment is viewed not as a means of punishment but as a method to safeguard the community. (“Home Guard” translates to the Norwegian term Gem Vernet.)

Halden Prison, a maximum security institution in Norway, was opened in 2010. It featured barred windows, private bathrooms, televisions, and high-quality furnishings within cells. Inmates dined and socialized with unarmed correctional staff rather than traditional guards and were incentivized to work for compensation. Outsiders often compared the facility to a luxurious hotel. Meanwhile, reports of inmate mistreatment surged in American prisons throughout the early 21st century. Norway’s recidivism rate stood at approximately 20% after two years, in stark contrast to the UK’s and the US’s 60-70%. Despite its costs, Halden provided effective rehabilitation and ultimately saved funds in the long run.


The AI monitored the prisoners’ behavior, tracking their website visits as well as messages and calls made.

Even in progressive Scandinavia, there were citizens who believed in punishment for wrongdoers. However, sociologists discovered that informing the public about the detrimental effects of excessive and cruel punishment on society ultimately leads to a perception that alternatives could be superior. This was the central aim of the Home Guard.

The initial self-fencel (“Self-Prison”) trial commenced in Norway in 2030. Participants received secure ankle bracelets for GPS tracking and wore harnesses that continuously captured images of their faces, processed through facial recognition software to prevent transfer to another individual. AI systems thoroughly monitored the inmates’ activities, including website visits and communication.

In the event of a breach of prison rules, a conducted energy device, typically found in stun guns, was integrated into the ankle bracelet to deliver an electric shock upon detection of any infractions. Authorities were then alerted.

The Home Guard scheme was initially proposed in 2018 by Dan Hunter and his teammates at King’s College London, who concluded that self-imposed prisons were significantly less costly than traditional ones over a complete sentence, even with the annual replacement of technology. Naturally, as technology became more affordable, expenses diminished further.

The first self-fencel trials took place in Bergen, where all prisoners not convicted of serious offenses were outfitted with the self-imprisonment technology and sent back to their homes. This initiative was a remarkable financial triumph and reinforced the message that physical prisons are costly, inhumane, inefficient, and antiquated. For global observers, it became evident that traditional prisons failed to adequately protect society, given their high recidivism rates.

Technical confinement proved to be superior; self-fencel quickly proliferated throughout Scandinavia. Trials were eventually conducted across Europe, and later in India, Mexico, Brazil, Australia, and even the United States. By 2050, 95% of prisons in these regions were closed. The savings were redirected toward education and healthcare, resulting in decreased crime rates as societal advancements and the reality of constant surveillance encouraged law-abiding behavior. Parents reminded their children, “Obey the law, or you’ll end up in jail,” and this threat resonated.

Rowan Hooper serves as the podcast editor at New Scientist and is the author of How to Spend a Trillion Dollars: The 10 Global Issues We Can Actually Fix. Follow him on Bluesky @rowoop.bsky.social. In Future Chronicles, he imagines a future filled with innovative inventions and developments.

topics:

  • artificial intelligence/
  • technology

Source: www.newscientist.com

Martian Permafrost May Contain Viable Liquid Water Channels

Solar Panel and Robotic Arm of NASA’s Phoenix Lander with Sample in Scoop

NASA/JPL-California Institute of Technology/University of Arizona/Texas A&M University

Mars might harbor a system of liquid water flowing beneath its icy surface. Similar to permafrost on Earth, which is theorized to have thin veins of liquid minerals, new models suggest these veins on Mars could be substantial enough to sustain life.

“For Mars, we’re constantly flirting with the edge of habitability. Initially, I theorized this study would reveal that adequate water wouldn’t exist, thus making microbial life impossible,” states Hannah Sizemore from the Planetary Science Institute in Arizona. “I was mistaken.”

Sizemore and her team analyzed Mars’ soil composition to estimate the amount of icy soil that might actually comprise liquid water and the dimensions of the channels through which it flows. Temperatures on Mars can plummet to -150°C (-240°F), challenging the existence of liquid water. While pure water freezes at 0°C, the presence of salts—widespread on Mars—can significantly lower the freezing point.

The research indicated that it is “surprisingly feasible” to find soil containing over 5 percent liquid water in channels exceeding 5 microns in diameter. This threshold was deemed necessary for a vein to be classified as habitable. “The largest veins we’re referencing are 10 times narrower than a fine human hair,” Sizemore elaborates. “Nonetheless, it’s a sufficiently expansive environment to host microorganisms, allowing for the transfer of nutrients and waste within the ecosystem.”

Based on soil data collected by NASA’s Phoenix spacecraft, which landed on Mars in 2008, these networks of waterways may be prevalent at latitudes above 50 degrees. Sizemore indicated that if life exists on Mars, liquid veins would be prime locations for investigation, proposing that “this is a site where one could land and excavate around 30 centimeters to collect samples.”

The primary concern regarding these veins as potential habitats is their temperature, which can be significantly below what most known life forms can endure. “However, we must exercise caution in applying the limits observed for terrestrial organisms to other life forms, as they do not necessarily define the survival limits for all life that could exist elsewhere,” states Bruce Jakosky from the University of Colorado Boulder. “Ultimately, this study and related research suggest that the existence of life near the Martian surface is not out of the question.”

Topics:

  • Mars/
  • Extraterrestrial Life

Source: www.newscientist.com

Civet Coffee: Unveiling the Real Chemistry Behind This Unique Indulgence

Palm civet

Krit Afshen/Shutterstock

Beans from civet cat droppings possess distinct chemical properties that help explain their gourmet status.

The palm civet (Paradoxulus hermaphroditus), resembling a mongoose, is indigenous to South and Southeast Asia. Civet coffee, or kopi luwak, stands out as one of the most extraordinary luxury drinks, fetching over $1,000 per kilogram of beans that have undergone digestion by a civet.

Kopi luwak is primarily produced in Indonesia, the Philippines, and Vietnam, with minor production in other nations like India and Timor-Leste. However, animal rights organizations are advocating for consumers to avoid this industry. They allege that many civets are kept in deplorable cage conditions.

To investigate how coffee beans transform during a civet’s digestive process, Parati Aresh Shinu and their research team from the Central University of Kerala in India gathered coffee samples from five farms near Kodagu in the Western Ghats of India.

These farms are home to civets that roam freely, and workers regularly collect beans from their droppings to blend with the harvest of tree-grown coffee beans. “At our site, civets and planters interacted harmoniously,” Sinu mentions. “We aim to educate farmers regarding the chemical composition.”

The researchers retrieved around 70 pieces of civet dung containing coffee beans and subsequently hand-harvested the coffee from the Robusta trees on the plantation, performing tests to analyze crucial chemical elements like fat and caffeine.

The fat content of civet beans was notably higher than that of beans directly from trees, while levels of caffeine, protein, and acid were marginally lower. This decrease in acidity is likely a result of fermentation during digestion.

Significant differences were also found in the volatile organic compounds present in civet coffee versus regular coffee beans. Some of these compounds can be found in conventional coffee, while civet beans either lack them altogether or possess only trace amounts.

The research team proposes that the elevated fat content in civet coffee may enhance its distinctive aroma and flavor, while reduced protein levels could lessen bitterness.

Sinu criticized the practice of confining civet cats for kopi luwak production, expressing hope that further studies could lead to the development of an artificial fermentation process mirroring the coffee’s natural chemical composition.

“We believe that the gut microbiome might play a role in the fermentation process,” Sinu explains. “Understanding the enzymes involved in digestion and fermentation could enable us to produce civet coffee artificially.”

topic:

Source: www.newscientist.com

Standard IVF Tests Overlook Certain Genetic Abnormalities in Embryos

Colored light micrograph of a human embryo following in vitro fertilization

Zephyr/Science Photo Library

During in vitro fertilization (IVF), embryos are subjected to genetic screening prior to being placed in the uterus. Recent studies, however, have shown that the common tests may fail to identify genetic abnormalities arising shortly before implantation. The implications for choosing embryos that are likely to lead to a healthy pregnancy remain uncertain.

This process, known as preimplantation genetic testing for aneuploidy (PGT-A), is conducted about 5 to 6 days after fertilization. It involves extracting cells from the embryo’s outer layer to assess for chromosomal irregularities, which can elevate the risk of miscarriage. However, this testing only captures a moment in time, as cellular division continues and may introduce genetic changes prior to implantation.

To address this gap, Ahmed Abdelbaki and his colleagues at the University of Cambridge monitored the progress of human embryos 46 hours post-thawing, replicating the timeline from evaluation to implantation. Typically, the embryo takes 1 to 5 days to implant after being transferred to the uterus. Given that embryos are highly sensitive to the light from traditional microscopes, prior studies only managed to observe them for about 24 hours. The research team employed light-sheet microscopy, a technique that illuminates only a thin slice of the embryo at once, minimizing light exposure and enabling longer observation durations.

In their experiment, the researchers injected 13 human embryos with a fluorescent dye that attaches to DNA, facilitating real-time tracking of genetic abnormality formation. They recorded the division of 223 cells and discovered that 8% exhibited chromosomal misalignment. This misalignment occurs when chromosomes improperly arrange themselves before cell division, significantly raising the likelihood of creating cells with abnormal chromosome counts, potentially hindering implantation, increasing miscarriage risk, and leading to conditions such as Down syndrome.

This indicates that genetic changes might arise later. “These variances appear in the embryo subsequent to PGT-A screening,” stated Lily Zimmerman from Northwell Health in New York.

These chromosomal errors were restricted to the outer cell layer responsible for forming the placenta, rather than the central cells that mature into the fetus. Previous findings suggest that successful pregnancies can occur even with certain genetic abnormalities in the outer cells. Thus, Abdelbaki posits that these genetic errors may not detrimentally impact the embryo’s survival chances.

“In my view, this study highlights the necessity for further research in embryo screening. It’s not simply a matter of categorizing embryos as genetically normal or abnormal,” commented Professor Zimmerman. She also noted that it remains unclear how genetic alterations occurring between screening and implantation might influence embryo viability, and given that the study examined only a small sample of embryos, the broader applicability of these findings is uncertain.

Topics:

Source: www.newscientist.com

Solar Energy Will Transform the World Sooner Than You Imagine

The Future of Solar Power is Promising

Liu Fuyu/Shutterstock

Can solar energy dominate the global power landscape? Recently, the rate of solar power installation has increased dramatically, with capacity doubling between 2022 and 2024, now providing 7% of global electricity. What are the future projections?

In the first half of 2025, solar and wind energy reached historic milestones by surpassing coal in electricity generation for the first time, making renewables the leading electricity source worldwide. According to the UK-based think tank Ember, solar power has been the primary contributor to this pivotal shift in the energy landscape, accounting for 83% of the surge in global electricity demand this year. Ember’s analysis shows that solar has been the largest new power source for three consecutive years.

What’s the advantage of solar? Its affordability! Installation costs for solar systems have plummeted by 90% over the past 15 years, making solar energy the most economical electricity source globally. “Currently, silicon panels are on par with the cost of plywood,” remarks Sam Stranks, from Cambridge University.

This translates to abundant, cost-effective energy solutions that can be implemented almost anywhere. Is it unrealistic to envision a future where solar energy powers everything?

On a fundamental level, Earth receives almost limitless solar energy. Even with current panel efficiencies, roughly 450,000 square kilometers would be needed to meet the entire world’s energy demands using solar power, as estimated by a 2021 report from the British think tank “Carbon Tracker.” This represents just 0.3% of global land area.


Kingsmill Bond, one of the report’s authors now working with Ember, noted that while land usage trade-offs exist—like competition with agriculture—”there’s ample space for most nations to adopt these technologies.”

Next-Gen Solar Panels

The question is, what hinders solar energy from fully dominating the global electricity market? Efficiency is the foremost challenge. Photovoltaic panels primarily made of silicon convert about 20% of solar energy into electricity. In contrast, hydroelectric power plants convert 90%, wind turbines around 50%, and fossil fuel plants 30-40%.

This disparity necessitates more solar panels to equate to the output of other energy sources. Therefore, companies and researchers are eager to enhance solar panel efficiency, hoping the improvements will concurrently reduce costs and land requirements.

However, crystalline silicon panels are approaching efficiency limits, with top-tier cells currently achieving around 25% efficiency. “The practical ceiling for crystalline silicon is likely around 28%,” explains Jenny Nelson from Imperial College London.


Further efficiency improvements may require a transition to tandem solar cells, which utilize an additional semiconductor to better harness the solar spectrum. Tandem silicon perovskite cells are considered the most promising, with a theoretical efficiency limit near 50%. Although real-world tandem panels haven’t reached that potential, Stranks anticipates efficiencies between 35% and 37%.

The first tandem silicon perovskite solar panels have commenced commercial production. They are now undergoing industry tests to assess their real-world operational longevity. Stranks is optimistic, projecting they will become the market’s leading technology in a decade. “On the surface, they appear similar to current panels, but they generate 50% more power,” he states. “That’s a significant advancement.”

Efficiency enhancements could not only cut costs further but also foster new application opportunities, such as solar roofs on electric vehicles that can charge batteries during the day. This stored energy could then be utilized for transportation or domestic use after sunset, he adds.

Solving Storage Issues

Innovations like these could mitigate one of solar power’s primary challenges: variability. The sun isn’t always shining, which poses less of an issue in Sunbelt countries like India, Mexico, and parts of Africa, where sunlight is almost year-round, enabling surplus energy during the day to be stored for nighttime use. This solar and storage model is becoming more affordable, with lithium-ion battery costs declining 40% in the past two years, according to BloombergNEF.

“Ultimately, fossil fuels’ only edge over solar is their storage capabilities,” Bond points out. “However, this issue is mostly resolved through advancements in battery technology.”

In northern regions, where winter days are short and overcast, the scenario is different. “[Solar] serves as an incredibly effective energy source, producing zero pollution with a rapid energy investment return. It ticks all the right boxes,” comments Andrew Blakers from the Australian National University. “Unless you reside in northern Europe, northeast Asia, or the northeastern United States—where you have abundant summer sun but limited winter light—[solar] is distinctly superior.”

For areas experiencing long winter nights, wind energy can bridge the gap, but we must also develop energy storage solutions capable of holding power for extended periods. Such “seasonal storage” technology is still emerging, with only a few solutions at commercial scales. However, methods like pumped water, hydrogen, and compressed air storage show promise. “In the short term, batteries will suffice for now, while pumped hydro storage will take over in the long run,” predicts Blakers.

Political Challenges

If anything, enhancing efficiency and storage represents low-hanging fruit. “The bottlenecks are likely political, with inconsistencies in policy, regulatory challenges, and vested interests from other industries,” says Nelson.

The Trump administration in the U.S., known for its climate change skepticism, epitomizes this issue. Recently, federal authorities halted a massive solar project in Nevada that was set to be the world’s largest, continuing a trend of reducing solar funding and obstructing initiatives.

Yet, Bond is confident the shift to renewable energy is nearly inevitable, given its economic advantages over conventional power sources. “While certain companies may slow the solar tide in specific countries or projects, the current U.S. government is inadvertently jeopardizing the nation’s position in the global race for advanced technology deployment,” he asserts.

Blakers concurs, emphasizing that solar energy might be the solution to the rapidly increasing energy demands from AI data centers. “Even in the U.S., with a determined federal approach, it’s hard to envision solar moving backward since many states favor solar, and it’s by far the most expedient method to procure substantial energy,” he notes.


Another significant obstacle for clean energy is logistics. Existing power grids will need rewiring to accommodate large and varying energy supplies from new regions. A more adaptable grid that manages generation spikes and fine-tunes electricity demand will optimize green electricity usage. However, achieving these advanced power grids will incur substantial costs. In the UK alone, energy firms plan to invest £77 billion over the next five years to upgrade the electricity grid for wind and solar integration.

In low-income countries with less developed electricity grids, there’s an opportunity to expediently establish renewable-friendly infrastructures from scratch, facilitating deeper penetration of renewables into their grid supply. Currently, the BRICS nations (Brazil, China, Egypt, Ethiopia, India, Indonesia, Iran, Russia, South Africa, and the United Arab Emirates) together produce more than half of the world’s solar power generation, according to Ember.

The broader challenge for many nations is to electrify a larger share of their energy needs—covering heating, transportation, and more—which is crucial for decreasing fossil fuel reliance throughout the global economy. “To decarbonize our planet, electrification is a priority,” Nelson emphasizes. Low-income countries are currently leading the charge against wealthier ones, with China’s portion of electricity in final energy consumption set to hit 32% in 2023, far eclipsing the 24% electrification rate of the United States and affluent European nations, as noted by Ember.

What Lies Ahead for Solar?

Despite the year’s achievements, the technical, logistical, and political hurdles mentioned could hinder solar PV adoption in some regions in the short term. The International Energy Agency announced that renewable electricity is set to more than double by the end of 2030, yet it might not meet the target of tripling capacity by that time. The agency identified changes in U.S. policy and challenges related to grid integration as resisting factors against expanding renewable capacity.

However, energy market analysts remain optimistic that solar power will lead the global energy supply by mid-century. “By century’s end, it’s clear that all our electricity will derive from renewable sources, primarily solar,” asserts Bond, who forecasts that solar energy could account for up to 80% of the world’s electricity supply by 2100. Additionally, he expects that a minimum of 80% of the total global energy needs will be electrified.

All political, storage, and infrastructure barriers will eventually fade, paving the way for a green power revolution. “Human ingenuity drives us to convert energy into resources,” Bond concludes. “Now that we have discovered this affordable and universal energy source, it’s only a matter of time before we harness it.”

Topics:

  • Solar Power/
  • Renewable Energy

Source: www.newscientist.com

Microbial Colors in Clouds May Indicate Life on Other Planets

The clouds in our atmosphere host a myriad of bacteria, fungi, and viruses.

George Pachantouris/Getty Images

Scientists have for the first time measured the colors of microbes residing in high-altitude clouds, providing insights that could aid the search for extraterrestrial life.

Microorganisms have been found in Earth’s atmosphere at densities reaching up to 100,000 per cubic meter, contributing to cloud formation.

These tiny life forms produce pigments to shield themselves from intense ultraviolet radiation present at high altitudes.

Thus, if similar airborne organisms are present in the atmospheres of other planets, they might be detectable from afar by studying the light wavelengths, or spectra, reflected by those planets. Ligia Coelho from Cornell University in New York notes.

“Essential pigments are robust and surprisingly universal biosignatures,” Coelho explains. “Ultraviolet light is a common stressor for life on any planet with a star, suggesting that reflective pigments serving similar roles could evolve elsewhere.”

To investigate the colors of airborne microorganisms on Earth, Coelho’s team cultured microbes collected by Brent Kritner from the University of Florida and colleagues. Kritner’s team employed helium balloons to collect microorganisms attached to sticky rods at altitudes between 3 and 38 kilometers above the Earth.

Subsequently, Coelho’s team analyzed the reflectance spectra of the colored compounds produced by these microbes, observing a spectrum of colors from yellow to orange to pink, manifested by carotenoid pigments like beta-carotene, commonly found in carrots.

Finally, the team simulated how these spectra might alter across various planetary conditions, including wetter and drier environments.

“For the first time, we possess actual reflectance spectra of pigmented microorganisms in the atmosphere, which can serve as reference points for modeling and detecting life forms within clouds,” stated Coelho.

Astronomers are actively searching for signs of life beyond our solar system by analyzing light reflected from planets, which reveals the chemical footprints of gases—like oxygen and methane—that may be produced by biological activities, as well as indicators of surface life such as green chlorophyll generated by vegetation and microorganisms.

Up until recent findings, clouds surrounding exoplanets were perceived as obstructions, hindering the identification of atmospheric and surface-level biosignatures.

“Our planetary simulations indicate that when exoplanetary clouds are rich in these microorganisms, their spectra can change in identifiable ways,” Coelho elaborates.

Forthcoming space telescopes, such as NASA’s proposed Habitable World Observatory, could bolster efforts to search for life in other star systems.

Nevertheless, even with advancements in technology, the concentrations of airborne microorganisms need to be significantly high to be detected from extensive distances. “The concentrations of these organisms present in Earth’s atmosphere are currently below our detection limits,” Coelho remarked.

“According to the expected resolution of NASA’s Habitable World Observatory (which we modeled in this study), we would require microbial cell densities akin to those found in oceanic algal blooms, which are typically detectable from space.”

Claire Fletcher, a researcher from the University of New South Wales, suggests that it may be advantageous to search for carotenoids produced by microbes in the stratosphere alongside chlorophyll from plant life. “However, while we assume that life on these exoplanets will mirror that of Earth, this assumption may not hold true,” she cautions.

Peter Tuthill, a professor at the University of Sydney, expresses skepticism regarding the utility of the stratospheric biosignatures identified in the study for extraterrestrial life detection. “I appreciate the fact that we don’t need to engineer devices to detect biosignatures amidst noise from distances of 20 parsecs,” he remarks.

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Source: www.newscientist.com

An Essential Guide to Navigating the Complexity of the COP Summit

Peter Betts (seated, in a pink shirt) at COP17 in Durban, South Africa, 2011

IISD/ENB Leila Mead

Climate Diplomat
Peter Betts, Profile Edition

Next month, climate negotiators, advocates, and global leaders will gather in Belem, Brazil, for COP30, this year’s United Nations climate change summit.

For those who have attended a COP summit or observed it from a distance, the experience can be quite overwhelming. Numerous negotiation sessions occur at once, filled with intricate topics and jargon—everything from “dialogue” and “consultations” to “informal informal” discussions.

To an onlooker, it may seem like a bustling marketplace, steeped in its unique customs and largely disconnected from the outside world. Fortunately, the insights of Peter Betts, a well-respected figure in COP circles, offer clarity.

While many outsiders may not recognize Betts, he was the former chief climate change negotiator for the UK and EU, instrumental in laying the groundwork for the Paris Agreement and guiding the negotiations that culminated in 2015.

Sadly, Mr. Betts passed away from a brain tumor in October 2023. His posthumously published book, Climate Diplomats: A Personal History of the COP Conference, released in August of this year, provides a comprehensive view of the inner workings of the climate summit and chronicles the modern history of these events, starting from Betts’s appointment as head of UK international climate policy in 1998.

One key revelation is that while COPs are often set in exotic locales—from Peru to Paris, and Durban to Dubai—the life of a climate negotiator is anything but glamorous. Teams spend years preparing negotiating strategies for the two-week summit, yet they often find themselves confined to windowless temporary structures, finalizing crucial details.


Amid the chaos, negotiators must find a way to get everyone to the table and reach agreement

During COP17 in Durban, Betts recounted how delegation offices were set up in a parking garage basement that “reeked of petrol and diesel,” while at COP15 in Copenhagen, meals consisted solely of large circular bread rolls filled with bland paste. Clearly, climate diplomats are not drawn to a life of luxury; their dedication to addressing the climate crisis is evident.

Through his writing, Betts guides readers on a whirlwind journey of how COP summits function, explaining the rules governing these meetings as well as the goals and positions of each participating nation.

The scale of the challenges is immense. Some countries prioritize securing increased financial assistance for development, others aim to commit nations to ambitious greenhouse gas emissions reductions, while some seek to maintain the status quo. Domestic politics, economic circumstances, and cultural perspectives further complicate negotiations.

In the midst of chaos, negotiators are tasked with uniting all parties to agree on next steps in combating climate change. This is no small feat.

Betts possesses a knack for clear communication and often employs dry humor, even when discussing the complex intricacies of multilateral climate finance. Through his narratives, readers begin to understand the meticulous crafting of a balanced agenda that aims to bring nations together towards a shared goal.

Things become particularly engaging when readers are granted behind-the-scenes access to pivotal summits like Copenhagen, Paris, and Glasgow. Betts shares anecdotes of prime ministers and presidents “eating biscuits like robots” during high-stress meetings, creating headlines at unplanned “damaging” press conferences, retreating into VIP areas to avoid their teams, and “erupting” in frustration when outcomes don’t align with their desires.

There’s no shortage of gossip about influential figures in Whitehall to keep British politicians intrigued, along with insights into the pitfalls of climate change advocacy efforts, which have, at times, hindered progress in emission reductions.

Despite criticisms suggesting that summits merely function as prolonged spectacles, evidence indicates they play a significant role in spurring global climate action. Before the signing of the Paris Agreement in 2015, projections suggested a potential increase of 5°C in global temperatures by the end of this century. Now, a decade later, that trajectory has shifted to approximately 2.7°C—still excessive but far from the dire future we once faced.

Diplomacy has the power to reshape the world. In this enlightening book, Betts unveils the intricate mechanisms behind this transformation.

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Source: www.newscientist.com

Optimized Lithium-Ion Batteries: Capable of Penetration Without Ignition

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Nail penetration tests on standard batteries (top) and those with enhanced electrolytes (bottom)

Professor Yi-Chun Lu, Chinese University of Hong Kong

Altering just one material in lithium-ion batteries could mitigate the risk of uncontrollable fires resulting from punctures or bends, paving the way for safer battery production in the coming years.

Lithium-ion batteries found in smartphones, laptops, and electric vehicles consist of graphite electrodes, metal oxide electrodes, and a lithium salt electrolyte in a solvent. This liquid electrolyte facilitates ion flow, enabling battery charging in one direction and energy release in the opposite direction to power devices.

However, if these batteries are punctured and a short circuit occurs, the stored chemical energy can be released rapidly, with the potential to ignite a fire or cause an explosion.

To combat these risks, researchers have proposed alternative battery designs that incorporate protective gels and solid substitutes for liquid electrolytes. For instance, Yue Sun and colleagues at the Chinese University of Hong Kong have engineered a safe design that merely involves changing the electrolyte material.

Fires often result when negatively charged anions sever their bond with lithium in the battery. Once these bonds break, excessive heat is produced, leading to a destructive cycle known as thermal runaway.

To address this issue, the researchers developed a secondary solvent called lithium bis(fluorosulfonyl)imide, which only binds to the existing solvent’s lithium at elevated temperatures, where thermal runaway initiates. Unlike conventional solvents, this new material prevents the existence of anionic bonds, thus averting the dangerous heat release cycle. When subjected to a nail penetration test, the temperature in the battery only increased by 3.5°C, contrasting with the over 500°C generated by traditional batteries.

“The problematic element is anions. Anions possess significant bond energy, and it’s their bond disruption that triggers thermal runaway,” says Gary Leeke at the University of Birmingham, UK. “This isolates the harmful elements from the process. It represents a significant leap forward in battery safety.”

Testing revealed that batteries using the new solvent retained 82% of their capacity after 4,100 hours, showing competitiveness with existing technologies.

Leeke stated that the outcomes of this research could be integrated into next-generation batteries that could be mass-produced within three to five years.

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Source: www.newscientist.com

Wegovy Improves Heart Health Even with Slight Weight Loss

Increasing evidence suggests that GLP-1 drugs like Wegovy offer benefits beyond treating obesity and type 2 diabetes.

Shelby Knowles/Bloomberg via Getty Images

Research indicates that the weight-loss medication Wegovy can lower the risk of heart attacks and other cardiovascular conditions, even in individuals who may not experience significant weight loss or those who aren’t severely obese.

Earlier findings from the SELECT trial hinted that Wegovy, a GLP-1 weight-loss drug, could have these heart health benefits, but it remained unclear if they were solely due to weight reduction. Studies involving pigs suggested a direct protective effect on the heart, now validated in humans.

“The important takeaway is that the cardiovascular advantages of these drugs occur independently of weight loss. This repositions them as drugs that modify diseases rather than merely aiding weight loss,” explains John Deanfield from University College London.

Wegovy contains semaglutide, a GLP-1 treatment, as well as Ozempic, which is designed for managing type 2 diabetes. While these treatments are approved for weight management and diabetes, they have shown promise in various other conditions, including dementia and alcoholism.

The SELECT trial assessed semaglutide against placebo regarding cardiovascular risks in 17,604 participants aged 45 and older who were overweight or obese. None were diabetic, yet all had some heart disease. In November 2023, Deanfield et al. announced that semaglutide reduced the likelihood of heart attacks, strokes, and other severe cardiac events by 20%.

Researchers are analyzing data to determine if these effects are solely due to weight loss, examining various body mass index (BMI) and weight loss ranges. They discovered that individuals starting with a BMI of 27—categorized as mildly obese—showed improved heart disease risk after using semaglutide, as did the severely obese with a BMI of 44.

Interestingly, the degree of weight lost seemed to have minimal impact on cardiovascular improvements, whether during the initial 20 weeks or throughout the nearly two-year study.

However, abdominal fat appears to play a significant role. Researchers noted that a slimmer waist at the study’s onset correlated with reduced heart disease risk, regardless of whether participants received semaglutide or a placebo. Moreover, after years on semaglutide, each 5-centimeter reduction in waist size was linked to a 9% decrease in cardiovascular event risk. The research team found that waistline reduction contributed to nearly one-third of the drug’s heart-protective effects, while the reasons for the other benefits remain unclear.

These results reinforce semaglutide’s potential beyond just weight management, as individuals in the placebo group even experienced a slight rise in heart disease risk while losing weight; this may be reflective of an underlying health issue, Deanfield notes.

Further studies are required to unpack how semaglutide and potentially other GLP-1 medications exert these benefits. Professor Deanfield speculates that enhancements in blood vessel function and blood pressure could be at play, alongside possible anti-inflammatory effects.

“Inflammation is a crucial mechanism influencing various diseases we want to avoid,” he mentions. “This appears to be a shared pathway targeted by these drugs.”

This advantage might also be linked to how semaglutide interacts with fat surrounding the heart, referred to as epicardial adipose tissue. Gianluca Iacobellis from the University of Miami highlights, “Semaglutide binds to epicardial adipose tissue receptors to enhance tissue health, consequently improving heart function and lowering cardiovascular event risks.”

“The query remains: What criteria should we establish to identify individuals most likely to benefit from these drugs?” questions Stefano Masi from the University of Pisa, Italy. “This is an ongoing challenge.”

topic:

  • Medical drugs /
  • heart disease

Source: www.newscientist.com

‘Enhanced’ CAR T-Cell Therapy Shows Potential in Treating Solid Tumors

Illustration of CAR T cell therapy targeting tumor cells

Illustration of CAR T cell therapy targeting tumor cells

Brainlight/Alamy

CAR T cells, which are immune cells modified to attack cancer, have transformed blood cancer treatments, particularly for leukemia. However, they have struggled against solid tumors. Recently, “weaponized” CAR T cells have successfully eliminated large prostate tumors in mice, providing optimism for similar therapies in humans.

“The tumor is completely gone,” states Jun Ishihara from Imperial College London, marking a unique achievement in animal research.

Our immune system typically identifies and destroys many cancers early on. Cancer cells often display mutated proteins recognized by T cells, which seek to eliminate these threats using surface receptor proteins, functioning similarly to antibodies.

However, not every cancer incites an immune response. In the 1980s, scientists found a way to engineer T cells to target cancer more effectively by incorporating genes for chimeric antigen receptors, hence the term CAR T.

While CAR T cells have shown remarkable success in treating some blood cancers, they also carry significant risks. They are effective for some but not all patients, and ongoing enhancements are needed. The development of CRISPR gene editing facilitates further improvements to these therapies.

Despite advancements, CAR T therapies remain ineffective for most solid tumors due to two primary challenges: the vast heterogeneity of solid tumors—where not all cells present the same mutated proteins—and the tumors’ ability to evade immune responses by emitting “do not attack” signals.

Researchers have attempted to enhance CAR T cells by incorporating immune-boosting proteins like interleukin-12, but this has sometimes resulted in overwhelming immune responses that damage healthy tissues.

Ishihara and colleagues have pioneered a method to localize interleukin-12 specifically to tumors. By fusing interleukin-12 to a protein that binds collagen, which is prevalent in tumors, they engineered it to target the exposed collagen found in both wounds and tumors. “Tumors are rich in collagen and are dense because of it,” Ishihara noted.

The modified CAR T cells produce this fusion protein when they bind to the mutated proteins present in certain prostate cancers. Once released, the fusion protein attaches to the tumor’s collagen, effectively signaling the immune system to launch an attack.

Trial results were promising, as the treatment eradicated 80% of large prostate tumors in the test mice. Additionally, when exposed to cancer cells afterward, no new tumors formed, indicating a robust immune response from the CAR T cells.

Remarkably, this approach did not necessitate preconditioning. Usually, chemotherapy is given to create space for new CAR T cells by depleting existing immune cells, risking side effects such as infertility. “We were surprised that no chemotherapy was required,” says Ishihara. His team aspires to commence human clinical trials within the next two years.

“This is a promising avenue that warrants clinical testing,” stated Stephen Albelda from the University of Pennsylvania. He noted that numerous research groups are also exploring similar methods for tumor-targeted localization of interleukin-12, with encouraging results being reported.

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Source: www.newscientist.com

New Research Uncovers How Reptiles Excrete Crystalline Waste in Large Quantities

Both avian and non-avian reptiles eliminate excess nitrogen as solid compounds known as “urate,” an evolutionary trait that aids in water conservation. Despite this adaptation, numerous questions regarding the composition, structure, and assembly of these biological materials remain unresolved. In a recent study, researchers from Georgetown University, the International Diffraction Data Center, Chiricahua Desert Museum, and Georgia State University investigated uric acid excretion in the desert. They focused on the ball python (python) along with 20 other reptile species, aiming to uncover efficient and versatile mechanisms for processing both nitrogenous waste and salts.

Thornton et al. investigated the solid urine of over 20 reptile species. Image credit: Thornton et al., doi: 10.1021/jacs.5c10139.

“All living organisms possess some form of excretory system. After all, what enters must eventually exit,” says the chemist from Georgetown University, Jennifer Swift, along with her colleagues.

“In humans, we eliminate excess nitrogen primarily through urine in the forms of urea, uric acid, and ammonia.”

“Conversely, many reptiles and birds efficiently package these nitrogenous compounds into solids, specifically urates, which are excreted through their cloaca.”

Scientists theorize that this process may have evolved to aid in water conservation.

“While crystallizing waste fluids may provide an evolutionary benefit for reptiles, it poses significant challenges for humans,” the researchers noted.

“Excess uric acid in the human body can crystallize in the joints, leading to painful conditions like gout, or form kidney stones in the urinary tract.”

In this recent study, the authors examined urate from over 20 reptile species to understand how these animals safely eliminate crystalline waste.

“Our research stems from a curiosity about how reptiles safely process this substance, and we hope it could inform new approaches to disease prevention and treatment,” Dr. Swift commented.

Microscopic analyses revealed that three species—the ball python, Angora python, and Madagascar tree boa—produce urate consisting of microscopically textured microspheres ranging from 1 to 10 micrometers in diameter.

X-ray examinations indicated that these spheres are comprised of even smaller nanocrystals of uric acid and water.

Furthermore, scientists have found that uric acid plays a crucial role in transforming ammonia into a less harmful solid state.

They hypothesize that uric acid may serve a similar protective function in humans.

“Our investigation of urate produced by various squamate reptiles sheds light on the sophisticated and adaptable systems they employ for managing nitrogenous wastes and salts,” the researchers stated.

“Understanding how dietary habits, environmental conditions, and aging impact sample analysis—along with advancements in instrumentation—offers a more comprehensive insight into the structure and function of biological urates.”

“The specifics of where and how these microspheres are created remain an intriguing question, yet their presence across different uric acid globule species suggests that this low-energy process is optimized under similar selective pressures.”

“Recognizing the role of uric acid in ammonia management could have significant implications for human health, although clinical research is required to verify this hypothesis.”

For further information, refer to the findings published today in the Journal of the American Chemical Society.

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Alyssa M. Thornton et al. Uric acid monohydrate nanocrystals: an adaptable platform for nitrogen and salinity management in reptiles. J. Am. Chemistry Society published online October 22, 2025. doi: 10.1021/jacs.5c10139

Source: www.sci.news

New Research Indicates Australia’s First Inhabitants Were Fossil Collectors

In a recent study, Professor Mike Archer from the University of New South Wales and his team revisited the fossilized tibia (the lower leg bone) of the now-extinct giant stenurine kangaroo. These bones, discovered in Mammoth Cave in southwestern Australia around World War I, provided solid evidence that Indigenous Australians hunted large animals, a finding in which Professor Archer was involved. A 1980 study had concluded that distinctive notches in the fossilized bones indicated slaughter. However, Professor Archer is now ready to acknowledge that this initial conclusion was incorrect.



Giant animal unearthed from mammoth cave about 50,000 years ago: giant long-beaked echidna Malayanglossus hackettii, giant kangaroo Procoptodon brauneorum, giant diprotodont Zygomaturus trilobus, and possum (Thylacinus cynocephalus). Image credit: Peter Schouten.

“As a scientist, updating the record as new evidence emerges is both my duty and responsibility,” Professor Archer stated.

“In 1980, we interpreted those cuts as signs of slaughter based on the best conclusions we could reach with the tools available to us then.”

“With advancements in technology, we now understand that our original interpretation was incorrect.”

“After the 1960s, there was a significant debate about whether Aboriginal peoples coexisted with Australia’s prehistoric megafauna or contributed to their extinction.”

“Many believed the incisions in the bones were made by humans using tools, suggesting that the extinction of megafauna and the arrival of humans approximately 65,000 years ago were not coincidental.”

“For decades, the bones from Mammoth Cave were seen as the ‘smoking gun’ indicating that Indigenous Australians hunted giant animals, but with that evidence dispelled, the discussion on megafauna extinction is now reopened, and the role of humans is more ambiguous than ever.”

To reexamine the same dissected stenurine leg bone, Professor Archer and his co-authors utilized advanced 3D scanning technology to analyze the bone without causing any damage.

They also employed modern radiometric dating methods to accurately determine the age of the bones and their cut surfaces while conducting detailed microscopic examinations.

Their findings indicated that the cuts were made after the bone had dried and cracked, suggesting the bones were likely already fossilized when the incisions occurred.

Paleontologists also investigated a fossilized tooth given to archaeologist Kim Ackerman by a Wora man from the Mowanjum mission, who had collaborated with Indigenous communities in the Kimberley during the 1960s.

This tooth, belonging to the Zygomaturus trilobus, a species of giant marsupial related to wombats, was part of Australia’s Pleistocene megafauna.

The tooth was retrieved from the Kimberley in northwestern Australia, and its characteristics closely matched other fossils found in Mammoth Cave in southwestern Australia.

Dr. Kenny Trabouillon from the Western Australian Museum remarked, “The discovery of this tooth in the Kimberley, far from its likely origin in Mammoth Cave, implies it may have been transported or traded by humans across great distances.”

“This suggests that cultural appreciation and symbolic usage of fossils existed long before the advent of European science.”

“The First Peoples might have been the continent’s, and possibly the world’s, earliest paleontologists.”

Researchers haven’t entirely dismissed the possibility of Aboriginal people having hunted Australia’s megafauna.

However, without concrete evidence, we cannot definitively assert that Indigenous Australians caused its extinction.

“While these remain hypotheses, we need substantiated proof before concluding that predation by Indigenous peoples contributed to the extinction of now-vanished megafauna, especially considering the long history of Indigenous peoples respecting and sustainably utilizing Australia’s wildlife,” Professor Archer stated.

“If humans were truly responsible for the unsustainable hunting of Australia’s megafauna, we would expect to find much more evidence of such hunting in the fossil record. Instead, the only solid evidence we had until now was this single bone, which now shows strong indications that the mutilations occurred post-mortem.”

If humans were not solely accountable for the extinction of Australia’s ancient megafauna, then what was?

Researchers indicate that many megafauna species went extinct long before humans arrived, and while some coexisted with humans for millennia, their decline often aligned with significant climate changes.

“What we can ascertain is that the First Peoples were the first in Australia to exhibit a keen interest in and collect fossils, likely thousands of years before Europeans arrived on the continent,” the researchers affirmed.

Their paper was published in the journal Royal Society Open Science.

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Michael Archer et al. 2025. Australia’s first people: hunters of extinct megafauna or Australia’s first fossil collectors. R. Soc. Open Science 12(10):250078; doi: 10.1098/rsos.250078

Source: www.sci.news

Physicists Suggest a Cosmic ‘Knot’ Could Have Influenced the Early Universe Briefly

Knots are prevalent in various fields of mathematics and physics today. A collaborative team of Japanese and German physicists proposes the existence of a “knot-dominated epoch” in the universe’s early days, suggesting that knots were essential building blocks during this time. This intriguing hypothesis can be investigated through gravitational wave observations. Additionally, they theorize that the conclusion of this period will involve the collapse of the knot due to quantum tunneling, leading to an Asymmetry between matter and antimatter in space.



Model proposed by Eto et al.. It suggests a brief, knot-dominated epoch when these intertwined energy fields outweighed everything else, a scenario that can be investigated through gravitational wave signals. Image credit: Muneto Nitta / Hiroshima University.

Mathematically, knots are defined as closed curves embedded in three-dimensional space and can be found not just in tying neckties but across numerous scientific disciplines today, as noted by Lord Kelvin.

Although his theory postulated that atoms are knots of etheric vortices was ultimately refuted, it sparked advancements in knot theory and its application in multiple areas of physics.

“Our study tackles one of the core mysteries of physics: why the universe is predominantly composed of matter rather than antimatter,” remarked Professor Munehito Nitta, a physicist at Hiroshima University and Keio University.

“This question is crucial as it relates directly to the existence of stars, galaxies, and ourselves.”

“The Big Bang was expected to produce equal amounts of matter and antimatter, with the intent that each particle would annihilate its counterpart, leaving only radiation.”

“Yet, the universe is overwhelmingly composed of matter, with only trace amounts of antimatter.”

“Calculations indicate that to achieve the matter we see today, only one extra particle of matter is needed for every billion matter-antimatter pairs.”

“Despite its remarkable achievements, the Standard Model of particle physics fails to resolve its inconsistencies.”

“That prediction is significantly off.”

“Unraveling the origin of the slight excess of matter, a phenomenon known as baryogenesis, remains one of the greatest unresolved enigmas in physics.”

By merging the measured baryon number minus lepton number (BL) symmetry with the Peksey-Quinn (PQ) symmetry, Professor Nitta and his associates demonstrated that the knot could have spontaneously formed in the early universe, resulting in the observed surplus.

These two well-studied extensions to the standard model address some of its most confounding gaps.

PQ symmetry offers a solution to the strong CP problem, which explains the absence of the small electric dipole moments that theories predict for neutrons, simultaneously introducing axions, a leading candidate for dark matter.

BL symmetry, conversely, elucidates why neutrinos, elusive particles that can seamlessly pass through entire planets, possess mass.

Maintaining the PQ symmetry globally, rather than merely measuring it, safeguards the delicate axion physics that addresses the strong CP problem.

In physics, “measuring” a symmetry implies allowing it to operate freely at any locale and moment in time.

However, this regional freedom requires nature to introduce new mechanisms for force transmission to clarify the equations.

By acknowledging BL symmetry, the researchers not only validated the existence of heavy right-handed neutrinos (crucial for averting anomalies in the theory and central to the primary burr formation model) but also incorporated superconducting behavior, likely providing the magnetic foundation for some of the universe’s earliest knots.

As the universe cooled following the Big Bang, its symmetry may have fractured through a series of phase transitions, leaving behind string-like defects called cosmic strings, which some cosmologists theorize may still persist.

Even though thinner than a proton, a cosmic string can stretch across a mountain.

As the universe expanded, these writhing filaments would twist and intertwine, preserving traces of the primal conditions that once existed.

The breakdown of BL symmetry formed a flux tube string, while PQ symmetry resulted in a flux-free superfluid vortex.

This contrast renders them compatible.

The BL flux tube grants the Chern-Simons coupling of the PQ superfluid vortex a point of attachment.

This coupling subsequently channels the PQ superfluid vortex into the BL flux tube, counteracting the tension that might otherwise disrupt the loop.

The outcome is a metastable, topologically locked structure known as a knot soliton.

“No prior studies had simultaneously considered these two symmetries,” notes Professor Nitta.

“In a way, our good fortune lay in this. By integrating them, we uncovered a stable knot.”

While radiation diminishes energy as waves traverse through space and time, knots exhibit properties akin to matter and dissipate energy far more gradually.

They subsequently surpassed all other forms, heralding an era of knot domination, where their energy density eclipsed that of radiation in the universe.

However, this dominance was short-lived. Ultimately, the knot succumbed to quantum tunneling, an elusive process where particles slip through energy barriers as though they were nonexistent.

This decay yielded heavy dextral neutrinos, a consequence of the inherent BL symmetry within its framework.

These colossal, elusive particles eventually transformed into lighter and more stable variations that favored matter over antimatter, shaping the universe we recognize today.

“Essentially, this decay releases a cascade of particles, including right-handed neutrinos, scalar particles, and gauge particles,” explained Dr. Masaru Hamada, a physicist at the German Electron Synchrotron Institute and Keio University.

“Among them, right-handed neutrinos are particularly noteworthy since their decay can inherently generate a discrepancy between matter and antimatter.”

“These massive neutrinos decompose into lighter particles, such as electrons and photons, sparking a secondary cascade that reheats the universe.”

“In this manner, they can be regarded as the ancestors of all matter in the universe today, including our own bodies, while knots might be considered our forebears.”

Once the researchers delved into the mathematics underlying the model—analyzing how efficiently the knot produced right-handed neutrinos, the mass of those neutrinos, and the degree of heat generated post-collapse—the observed matter-antimatter imbalance naturally emerged from their equations.

Rearranging the equations, with an estimated mass of 1012 gigaelectronvolts (GeV) for heavy dextral neutrinos, and assuming that most energy retained by the knot was utilized to generate these particles, the model yielded a natural reheating temperature of 100 GeV.

This temperature fortuitously coincides with the final opportunity for the universe to produce matter.

Should the universe cool beyond this point, the electroweak reactions that convert neutrino discrepancies into matter would cease permanently.

Reheating to 100 GeV may have also reshaped the cosmic gravitational wave spectrum, shifting it toward higher frequencies.

Forthcoming observatories such as Europe’s Laser Interferometer Space Antenna (LISA), the United States’ Cosmic Explorer, and Japan’s Decihertz Interferometer Gravitational-Wave Observatory (DECIGO) may someday detect these subtle tonal variations.

Dr. Minoru Eto, a physicist at Yamagata University, Keio University, and Hiroshima University, remarked, “The cosmic string is a variant of topological soliton, an entity defined by a quantity that remains unchanged regardless of how much it is twisted or stretched.”

“This characteristic not only guarantees stability but also indicates that our results are not confined to the specifics of the model.”

“While this work is still theoretical, we believe it represents a significant advancement towards future development, as the foundational topology remains constant.”

Although Lord Kelvin initially proposed that knots were fundamental components of matter, the researchers assert that their findings present the first realistic particle physics model in which knots could significantly contribute to the origin of matter.

“The next step involves refining our theoretical models and simulations to more accurately forecast the formation and collapse of these knots, connecting their signatures with observable signals,” said Professor Nitta.

“In particular, upcoming gravitational wave experiments like LISA, Cosmic Explorer, and DECIGO will enable the testing of whether the universe indeed experienced a knot-dominated era.”

The team’s work appears in the journal Physical Review Letters.

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Minoru Eto et al. 2025. Tying the Knot in Particle Physics. Physics. Pastor Rhett 135, 091603; doi: 10.1103/s3vd-brsn

Source: www.sci.news

High-Definition Video with Low Energy Consumption on Color E-Paper Screens

Gustav Klimt’s The Kiss presented on an iPhone (left) alongside a smaller e-paper display (right) showing the same artwork

Kingston Frameworks; Kunli Xiong et al. (2025)

A groundbreaking type of color e-paper is capable of showcasing vivid, high-resolution, full-color images and videos with minimal power consumption, heralding a potential new era for display technologies.

Unlike conventional LED screens, which produce colors through the emission of red, green, and blue light, e-paper screens utilize small molecules to generate images. Historically, these screens were restricted to black and white, but advancements have now allowed for color displays. However, they still face challenges in updating quickly enough for video playback.

To address this issue, Kunli Shion and their team at Uppsala University in Sweden have engineered electronic paper featuring pixels constructed from tungsten oxide nanodisks. Each pixel measures roughly 560 nanometers, resulting in an impressive resolution of 25,000 pixels per inch (PPI), whereas typical smartphone displays generally have resolutions in the hundreds.

The tungsten oxide nanodiscs are designed in various sizes and spacings to reflect distinct bands of light. By arranging them together, a range of colors can be created, with brightness adjustable through short electrical pulses that position ions within each disk. Once set, these ions maintain their placement, allowing the color to persist without a continuous power source.

The researchers constructed an e-paper display that measures just 1.9mm by 1.4mm, roughly 1/4000 the size of a conventional smartphone display, and utilized it to showcase a 4300×700 pixel segment of Gustav Klimt’s The Kiss – achieving remarkable resolution for such a compact device. It is also capable of refreshing approximately every 40 milliseconds, making it suitable for video display.

Another significant advantage of this novel e-paper technology is its remarkably low energy consumption, as noted by Xiong. The display utilizes about 1.7 milliwatts per square centimeter for video and around 0.5 milliwatts per square centimeter for still images.

“What I find impressive about this development is its capacity to support video at a rapid pace while consuming minimal energy, as each element remains switched after being activated,” comments Jeremy Baumberg from Cambridge University.

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Source: www.newscientist.com

Gene-Edited Pigs Resistant to Swine Fever: A Potential Advancement for Animal Welfare

Gene-edited pigs exhibit resistance to swine fever

Simon Lillico

By making a few genetic modifications, pigs can be rendered entirely resistant to swine fever, a significant issue for farmers globally. This gene editing could also confer resistance to related viruses in cattle and sheep.

The widespread adoption of gene-edited pigs resistant to swine fever is expected to enhance animal welfare, boost productivity, reduce greenhouse gas emissions, and lower retail prices. “This will foster sustainable livestock production and promote the well-being of pigs,” asserts Helen Crook from the UK Animal and Plant Health Agency.

Swine fever is a highly contagious viral illness that can lead to symptoms ranging from fever to diarrhea and miscarriage, often resulting in significant pig mortality.

While the disease has been eliminated in many regions, it can resurface. For instance, in 1997, the Netherlands culled 6 million pigs to contain an outbreak, and Japan has faced ongoing challenges since 2018.

Typically, when outbreaks occur, livestock are protected using vaccines containing live, weakened virus strains, which is a complex and costly process. “Vaccination demands extensive coordination and oversight,” mentions Christine Tate-Burkard from the University of Edinburgh, UK.

Countries utilizing vaccinations face restrictions when exporting to disease-free areas. Interruptions in vaccination programs can also lead to outbreaks, as seen recently in the Philippines, explains Tate-Burkard.

Nevertheless, the classic swine fever virus has a vulnerability. The viral protein bundles formed from long chains of amino acids must be cleaved into functional pieces, relying on specific pig proteins for this process.

By altering a single amino acid in this pig protein, referred to as DNAJC14, it may be possible to obstruct this cleavage. Tait-Burkard and colleagues employed CRISPR gene editing to create pigs with this minor modification.

Subsequently, the team sent some of these pigs to a secure facility, where Crook’s group introduced the live swine virus intranasally. All typical pigs fell ill, while the gene-edited pigs showed no signs of infection. There were no symptoms, antibodies, nor detectable virus.

“These pigs demonstrated complete resistance to viral replication and remained healthy and content throughout the experiment,” states Crook.

This research was partially sponsored by Genus, a major international breeding company currently evaluating the commercialization of these pigs.

Genus has previously developed gene-edited pigs resistant to another significant disease, porcine reproductive and respiratory syndrome, which are already approved in the United States, Brazil, and other nations. The company awaits approvals in Mexico, Canada, and Japan—key export markets for the U.S.—before it can start selling semen to farmers.

When used to implement small changes that can naturally occur, gene editing often faces less stringent regulations compared to traditional genetic engineering. Japan has already sanctioned three types of gene-edited fish.

The UK is anticipated to begin approving gene-edited plants soon, although regulations for livestock are yet to be finalized. It is expected that these regulations will prioritize animal welfare.

The research team observed no adverse effects in the swine fever-resistant pigs, according to Simon Lillico and colleagues from the University of Edinburgh, although further research is necessary to confirm these findings.

He emphasizes that traditional breeding lacks such welfare considerations. “It would be beneficial to ensure a level playing field,” he remarks. “We are aware that some conventionally reared animals experience low welfare standards.”

A virus closely related to classical swine fever is responsible for causing bovine viral diarrhea in cattle and borderline disease in sheep. While these diseases are not lethal, they still impact welfare and productivity. The Edinburgh research team is presently examining whether modifications made to pigs will also benefit cattle and sheep.

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Source: www.newscientist.com

Google Unveils Quantum Computers’ Ability to Unlock Molecular Structures

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Google’s Quantum Computing Willow Chip

Google Quantum AI

Researchers at Google Quantum AI have leveraged Willow quantum computers to enhance the interpretation of data sourced from nuclear magnetic resonance (NMR) spectroscopy—an essential research method within chemistry and biology. This significant advancement may open new horizons for the application of quantum computing in various molecular technologies.

While quantum computers have been most effectively demonstrated in cryptographic contexts, current devices face limitations in scale and error rates that hinder their competence in decryption tasks. However, they show promise in expediting the discovery of new drugs and materials, which align with the fundamentally quantum nature of many scientific procedures. Hartmut Neven and colleagues at Google Quantum AI have showcased one instance where quantum computers can mimic the complex interactions found in natural processes.

The investigation centered on a computational method known as quantum echo and its application to NMR, a technique utilized to extract detailed information regarding molecular structures.

At its core, the concept of quantum echoes is akin to the butterfly effect. This phenomenon illustrates how minor perturbations—like the flap of a butterfly’s wings—can trigger substantial changes in broader systems. The researchers exploited a quantum approach within a system made up of 103 qubits in Willow.

During the experiment, the team executed a specific sequence of operations to alter the quantum state of a qubit in a manageable way. They then selected one qubit to disrupt, acting as a “quantum butterfly,” and employed the identical sequence of operations, effectively reversing time. Finally, the researchers evaluated the quantum characteristics of the qubits to extract insights regarding the entire system.

In a basic sense, the NMR technique applied in the lab also hinges on minor disturbances; it nudges actual molecules using electromagnetic waves and examines the system’s reactions to ascertain atomic positions—similar to using a molecular ruler. If the operations on qubits can replicate this process, the mathematical scrutiny of the qubits can likewise be translated into molecular structural details. This series of quantum computations could potentially enable the examination of atoms that are relatively distant from one another, said team member Tom O’Brien. “We’re constructing longer molecular rulers.”

The researchers believe that a protocol akin to quantum echoes would require approximately 13,000 times longer on a conventional supercomputer. Their tests indicated that two distinct quantum systems could successfully perform a quantum echo and yield identical outcomes—a notable achievement given the inconsistencies faced in previous quantum algorithms supported by the team. O’Brien noted that enhancements in the quality of Willow’s hardware and reduced qubit error rates have contributed to this success.

Nonetheless, there remains ample opportunity for refinement. In their utilization of Willow and quantum echoes for two organic molecules, the researchers operated with a mere 15 qubits at most, yielding results comparable to traditional non-quantum methods. In essence, the team has not yet demonstrated a definitive practical edge for Willow over conventional systems. This current exhibition of quantum echo remains foundational and has not been subjected to formal peer review.

“Addressing molecular structure determination is crucial and pertinent,” states Keith Fratus from HQS Quantum Simulations, a German company focused on quantum algorithms. He emphasizes that bridging established techniques such as NMR with calculations executed by quantum computers represents a significant milestone, though the technology’s immediate utility might be confined to specialized research in biology.

Doris Sels, a professor at New York University, remarked that their team’s experiments involve larger quantum computers and more complex NMR protocols and molecules than prior models. “Quantum simulation is often highlighted as a promising application for quantum computers, yet there are surprisingly few examples with industrial relevance. I believe model inference of spectroscopic data like NMR could prove beneficial,” she added. “We’re not quite there, but initiatives like this inspire continued investigation into this issue.”

O’Brien expressed optimism that the application of quantum echo to NMR will become increasingly beneficial as they refine qubit performance. Fewer errors mean a greater capability to execute more operations simultaneously and accommodate larger molecular structures.

Meanwhile, the quest for optimal applications of quantum computers is ongoing. While the experimental implementation of quantum echoes on Willow is remarkable, the mathematical analysis it facilitates may not achieve widespread adoption, according to Kurt von Keyserlingk at King’s College London. Until NMR specialists pivot away from traditional methods cultivated over decades, he suggests that its primary allure will lie with theoretical physicists focused on fundamental quantum system research. Furthermore, this protocol may face competitive challenges from conventional computing methods, as von Keyserlingk has already pondered how traditional computing might rival this approach.

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Source: www.newscientist.com

The serum stimulates hair growth by imitating skin irritation effects.

Eczema-like stimulation promoted hair regrowth in shaved mice over 20 days (bottom row). Meanwhile, hair growth was notably less in shaved mice lacking this stimulation (top row).

Tai et al. 2025

Skin inflammation can encourage hair growth in mice by activating fat cells. The serum derived from this process may also benefit humans without causing discomfort.

While hair loss is often addressed with medications or steroid injections, more effective solutions are being researched, including stem cell therapies and drugs that reactivate dormant hair follicles.

Songjian Lin, among researchers at National Taiwan University, became intrigued by how adipose tissue influences hair growth during experiments with mice. “Unexpectedly, we found changes in the size of fat cells following skin inflammation. [Fat cells] shrink quickly before hair starts to grow back. We proposed that fat cells could release fatty acids via lipolysis to spur hair regeneration,” Lin explains.

To explore this further, they repeated the study and examined the relevant cells more closely. They initially applied an irritant to a shaved section of the mouse’s back to simulate eczema. By day ten, they noted that the mice’s hair follicles were actively growing, resulting in visible hair growth in those regions. This effect was absent in other shaved areas without eczema, as well as in control mice.

The research team observed that this phenomenon appears to occur because immune cells called macrophages migrate to the fat layer beneath the mouse’s skin, signaling fat cells to release fatty acids. These fatty acids are then utilized by hair follicle stem cells, promoting increased mitochondrial production, which supplies energy and fosters hair growth. This aligns with past studies indicating that plucking hair can trigger immune responses in nearby hair follicles, stimulating their growth.

Though eczema isn’t typically linked to hair growth in humans, other forms of skin inflammation may play a role, such as those associated with casts for broken bones, which are connected to excess hair growth.

Next, Lin and his team sought to determine whether fatty acids alone could induce hair growth without prior irritation. They formulated a serum containing various fatty acids dissolved in alcohol. This serum was applied to non-irritated shaved mice, and the results were compared to untreated areas and control mice. “We discovered that only monounsaturated fatty acids, like oleic acid and palmitoleic acid—prevalent in adipose tissue—successfully induced hair regrowth when applied topically,” Lin notes.

The researchers, who have since patented the serum, also observed encouraging outcomes when tested on human hair follicles in the lab and now intend to evaluate different dosages on human scalps.

Lin does not anticipate any serious side effects from the treatment. “Oleic acid and palmitoleic acid are naturally occurring fatty acids. They are present in high quantities in our fat tissue and various vegetable oils, making them safe for use,” he states. “I applied a solution of these fatty acids mixed with alcohol to my thighs for three weeks and noticed it stimulated hair growth.”

However, he cautions that the treatment hasn’t yet undergone testing on human skin, and animal models may differ significantly, especially concerning hair follicle biology. Christos Tziotsios from King’s College London also points out that similar serums are under development, including one utilizing plant extracts that promote hair growth in a matter of weeks.

Nonetheless, Tziotsios affirms that the latest findings enhance our comprehension of hair growth and loss. “We were aware of fat cells’ involvement in hair follicle formation, but this is the first instance we’ve witnessed them playing a role in hair regeneration,” he remarks. It could also clarify why certain individuals experience hair growth post-microneedling treatments, which involve rolling fine needles across the scalp to create micro-injuries that elicit an immune response.

Source: www.newscientist.com

Unveiling the Reality Behind F1’s New ‘Sustainable’ Fuel and Its Impact on Future Cars

In the upcoming year, Formula 1 (F1) is set to undertake one of its most ambitious transformations yet, shifting from fossil fuels to a fully sustainable fuel mixture. This initiative is part of a broader strategy to adhere to new environmental regulations and demonstrate that the sport can, as F1 puts it, “continue without the need for new car production”.

Nonetheless, skepticism remains. As F1 contributes over 1% of the total carbon footprint in sports, experts argue that there are far more significant environmental issues that F1 must address. What are these challenges and how can we overcome them?

Switch Gears

In 2020, F1’s governing body, the Fédération Internationale de l’Automobile (FIA), established a timeline for race car engines to transition to 100% sustainable fuel by 2026 and achieve carbon neutrality by 2030.

From 2023 to 2024, Formula 2 and Formula 3, F1’s supporting racing series, will start utilizing 55% ‘sustainable bio-based fuels’, transitioning to 100% ‘advanced sustainable fuels’ by 2025.

F1 has developed its own ‘sustainable’ fuel for 2026, designed specifically for the hybrid engines currently used in F1 cars, which consist of both an internal combustion engine (ICE) and two electric motor generators.

Images from the Japanese Grand Prix, which was rescheduled from autumn to spring to minimize carbon emissions related to equipment transport between races (Source: Formula 1) – Formula 1

According to F1, the new fuel will not raise the overall carbon levels in the atmosphere. The carbon used in these new fuels will be sourced from existing materials, such as household waste and non-food biomass, or it will be captured directly from atmospheric carbon dioxide.

This will enable the production of synthetic fuels, which are man-made fuels aimed at replacing the fossil fuel-based gasoline currently in use. In the long term, the FIA asserts that F1, 2, and 3 will all eventually adopt this “fully synthetic hybrid fuel”.

Moreover, this new fuel will be classified as “drop-in”, indicating that it will be compatible with existing internal combustion engines as well as the current fuel distribution infrastructure. This means the fuel powering F1 cars in 2026 will be the same fuel you could purchase at your local gas station today.

Is it Truly Sustainable?

However, as the term “sustainable” has gained popularity, experts have started to challenge F1’s assertions.

Dr. Paula Pérez-López, an expert in environmental and social sustainability at the MINES ParisTech Center for Observation, Impacts, and Energy (OIE), articulates that for a product to qualify as “sustainable”, it must fulfill certain environmental, social, and economic criteria, with each segment of the supply chain considering these factors.

“The term ‘sustainable’ should not be confused with ‘low carbon’. A product or process may exhibit low carbon emissions but still produce high levels of other pollutants, thus rendering it ‘unsustainable’. “

The FIA’s collaboration with the Zemo partnership, a UK-based nonprofit organization, has led to the introduction of the Sustainable Racing Fuel Assurance Scheme (SRFAS). This third-party initiative ensures that sustainable racing fuels comply with FIA regulations.

The certification mandates that the fuel comprises “at least 99 percent Advanced Sustainable Components (ASC)” that are certified to be derived from renewable energy sources such as non-biological origin (RFNBO), municipal waste, or non-food biomass.

Essentially, this means that the new fuel must be synthetic, produced from waste, or derived from materials not intended for human or animal consumption, such as specially engineered algae.

New fuels must also adhere to criteria such as the EU Renewable Energy Directive III (RED III) along with EU Delegated Law.

Fraser Browning, the founder of Curve Carbon, which advises companies on minimizing their environmental footprints, indicates that these new fuels can indeed facilitate genuine decarbonization efforts if managed appropriately.

“The overarching question pertains to F1’s complete impact,” he notes. “Is F1 pursuing synthetic fuels as a vital component of their sustainability goals, or is it merely a procedural formality?”

Browning emphasizes that advancements in motorsport have historically contributed to significant innovations in sustainable transportation. For instance, in 2020, Mercedes announced that hybrid technology would be utilized in road cars. Earlier this year, they also revealed a new battery technology capable of extending the range of electric vehicles by 25 percent.

“Without the innovations deriving from motorsport, hybrid vehicles wouldn’t have evolved at the present speed,” he contends. “However, this needs to be executed transparently and responsibly.”

Cutting Carbon

Beyond the transition to synthetic fuels, F1 is also making strides to reduce carbon emissions in other areas. Travel and logistics account for roughly two-thirds of F1’s carbon emissions, as teams, heavy machinery, and fans travel considerable distances between races each year.

To mitigate this, adjustments have been made to the F1 calendar for 2024 to lessen freight distances between events, as stated in F1’s latest Impact Report. For example, the Japanese Grand Prix has been synchronized with other Asia-Pacific races and moved to April.

Formula 1 has unveiled that DHL’s new fleet of biofuel-powered trucks minimizes carbon dioxide emissions by an average of 83% compared to traditional fuel-powered trucks during the European segment of the 2023 season (Source: F1) – Formula 1

Additionally, F1 has broadened the adoption of biofuels for the trucks used to transport equipment throughout Europe, resulting in a 9% reduction in logistical carbon emissions.

By the conclusion of 2024, total carbon emissions are projected to decrease by 26% from 2018 levels, although F1 acknowledges there remain “key milestones to achieve, including further investments in alternative fuels and updates to our logistics system to enhance efficiency”.

Synthetic Fuels vs. Electric Vehicles

What does it mean when F1 claims that its new synthetic fuel is a drop-in solution suitable for everyday vehicles? Could it serve as a more sustainable alternative to electric vehicles (EVs)?

Critics warn that producing synthetic fuels for internal combustion engines (ICE) is energy-intensive, costly, and may require five times the renewable electricity compared to operating a battery-powered electric vehicle.

At present, 96% of hydrogen used for these fuels within the EU is derived from natural gas, a process that releases significant amounts of CO₂. Currently, renewable hydrogen is more costly than fossil-based hydrogen.

“Obtaining pure and concentrated CO₂ poses a considerable challenge,” states Gonzalo Amarante Guimarantes Pereira, a professor at the State University of Campinas in São Paulo, Brazil, and co-author of a study comparing biofuels with pure electric vehicles.

“There is a technology known as direct air capture that can achieve this, but attaining 100% concentration comes with substantial energy costs. The estimated expense varies between $500 to $1,200 (approximately £375 to £895) per tonne, rendering e-fuels at least four to eight times more costly than operating an electric vehicle.”

Browning concurs that EVs represent a more favorable low-carbon choice for the future. “Their emissions during use and maintenance are significantly lower,” he states.

“While synthetic fuels might yield a lesser overall impact if managed wisely, we still lack a comprehensive lifecycle assessment across multiple sustainability metrics to definitively address this issue.”

In simpler terms, as long as the entire system producing synthetic fuels cannot be reliably demonstrated to have a positive environmental impact, the jury remains out on the actual extent of their effects.

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Source: www.sciencefocus.com

Data Reveals That the First Half of 2025 Marked the Most Fatal Weather Disaster Ever Recorded.

The initial months of this year marked the highest incidence of weather and climate disasters on record in the United States, as revealed by a recent analysis from the nonprofit Climate Central.

This crucial information may have remained unknown to the general public. Earlier this spring, the Trump administration shut down the National Oceanic and Atmospheric Administration’s program that monitored weather patterns. This event resulted in damages exceeding $1 billion. Adam Smith, the researcher who spearheaded the analysis, left NOAA in response to this decision.

Following his departure, Climate Central, a research organization dedicated to studying climate change impacts, employed Smith to revamp a database with records dating back to 1980.

Their latest analysis indicates that 14 individual weather events caused damages exceeding $1 billion in the first half of 2025. The wildfires in Los Angeles during January represented the most expensive natural disaster thus far this year, incurring costs over $61 billion, making it the most destructive wildfire recorded.

These findings illustrate that the financial toll from weather and climate disasters continues to escalate as extreme weather events become more frequent and severe, while populations migrate to areas increasingly vulnerable to wildfires and floods.

The report serves as a testament to the shift towards nonprofit organizations taking over federal initiatives that traditionally monitored and measured the effects of climate change, particularly as the Trump administration moves to scale back climate science funding. President Trump labeled climate change as a “crook’s job,” and the administration has reduced funding for clean energy initiatives while stripping the Environmental Protection Agency of its ability to control greenhouse gas emissions, which contribute to global warming.

Jennifer Brady, a senior data analyst and research manager at Climate Central involved in the project, noted that the staff was profoundly affected by the discontinuation of NOAA’s extensive disaster database, prompting them to take action.

“This has always been one of our most valued datasets. It narrates diverse stories. It articulates the narrative of climate change as well as the implications of where individuals reside and how they live at risk,” Brady stated. “I am ready to take it home.”

Kim Doster, a spokesperson for NOAA, expressed appreciation that the $1 billion disaster product has secured funding from sources other than taxpayers.

“NOAA remains committed to upholding ethical, unbiased research and reallocating resources to products that comply with executive directives aimed at restoring high standards in science,” Doster conveyed via email.

This database has been a source of political contention. House Republicans raised concerns with NOAA officials in 2024 regarding allegations of “deceptive data.” Recently, Senate Democrats proposed legislation to obligate NOAA to publish and update this dataset biannually, claiming it helps lawmakers in disaster funding decisions. However, this bill is currently stalled in committee and faces bleak prospects in the Republican-majority Senate.

Last month, officials from the Trump administration informed NBC News that NOAA terminated the database project due to uncertainty in accurately estimating disaster costs. The official highlighted that the project would incur annual costs of around $300,000, require considerable staff effort, and yield “pure information at best, with no clear objective.”

“This data is frequently utilized to bolster the claim that climate change enhances the frequency, severity, and expense of disasters, neglecting other factors like increased development in flood-prone and weather-sensitive areas as well as the cyclical variations in climate across different regions,” the official remarked at the time.

Despite this, Brady contends that the database has always acknowledged the significance of population shifts and climate change in exacerbating disaster costs.

She noted that Climate Central’s study employs the same methodologies and data sources as the NOAA database, including claims from the National Flood Insurance Program, NOAA storm event data, private insurance claims, and more.

This analysis captures the “direct costs” of disasters, such as damage to infrastructure, buildings, and crops, while omitting other considerations like loss of life, health-related disaster expenses, and economic losses to “natural capital” such as forests and wetlands. All data has been adjusted for inflation.

A recent evaluation of the first half of 2025 suggests that this year is on track to become the deadliest recorded year, despite the absence of hurricanes making landfall in the continental United States.

In the previous year, NOAA reported that $27 billion in disaster costs totaled around $182.7 billion, marking the second-highest total of billion-dollar disasters in the report’s history, following the figures from 2023.

Climate Central is not alone in its efforts to reproduce the work previously undertaken by the federal government as the Trump administration cut back on climate science.

A collective of dismissed NOAA employees established climate.us, a nonprofit successor to climate.gov, the former federal site that offered data and analyses to help the general public grasp climate issues. The site went offline this summer.

Edited by Rebecca Lindsay climate.gov. Before her termination in February, along with other NOAA colleagues who co-founded the nonprofit, Lindsay stated they had raised about $160,000 with plans to host climate.gov, where they will share their archives and begin publishing new articles on climate change in the upcoming weeks.

“We are preserving this information to ensure that when people seek answers about climate status, they can find them,” Lindsey asserted.

Both the American Geophysical Union and the American Meteorological Society have announced intentions to publish a special collection of studies focused on climate change, particularly after the Trump administration informed volunteer scientists working on the National Climate Assessment that their services were no longer required.

The administration dismissed employees from the U.S. Global Change Research Program, responsible for organizing the National Climate Assessment and coordinating climate research initiatives across various federal offices.

Walter Robinson, from the American Weather Society’s publication committee, highlighted that the National Climate Assessment was “effectively stopped” due to the government’s decision, which he described as an “abandonment” of federal duty.

Though the new collection cannot replace comprehensive assessments, it aims to consolidate the latest scientific understanding on climate change impacts within the United States, he added. The research will be featured in numerous scientific journals on an ongoing basis.

“Individuals are stepping up,” Robinson remarked regarding his group’s endeavors. “As scientists, we do our utmost.”

Source: www.nbcnews.com

Nurturing Your Infant’s Microbiome: A Foundation for Lifelong Mental Health

Families that garden together have more diverse microbiomes

Half Point Images/Getty Images

New parents often juggle numerous worries like sleep schedules, breastfeeding, and even the color of their newborn’s poop, but the baby’s microbiome might not top their list of concerns. Experts suggest it shouldn’t be a priority just yet.

“The initial 1,000 days of life are vital for establishing the microbiome. Once established, altering it is quite challenging,” says Federica Amati from Imperial College School of Medicine. Early microbial colonization plays a significant role not just in physical health, but also in brain development, mental well-being in adolescence, and even in reducing the risk of dementia in later life.

During a meeting I attended, this point seemed crucial for new parents. Goodwood Health Summit held this month in Chichester, England. However, after speaking with nutritionists, microbiologists, and doctors, I became convinced that the importance of introducing microbes early in a child’s life is paramount. There are straightforward, cost-effective strategies to navigate your child’s microbiome in a beneficial direction.

Why early microbiome health is essential

We’re frequently reminded that the trillions of microorganisms comprising our microbiome influence our bodies in various ways, from safeguarding our gut lining to controlling inflammation. But they also impact the brain.

Microbial byproducts influence the formation and adjustment of brain connections during early childhood, a pivotal process for healthy brain growth. Bacteria also communicate with the brain through the vagus nerve, affecting mood and stress levels. Persistent inflammation due to an unbalanced gut microbiome may contribute to depression and neurodegenerative diseases.

Moreover, research has linked microbial imbalance to conditions such as Parkinson’s disease and autism. Early studies suggest that children with autism may present unique microbiome profiles, and fecal transplants from non-autistic donors may offer improvements in both gastrointestinal and behavioral issues.

Ways to nurture the ideal microbiome

Once a microbial ecosystem is set up, overhauling it can be quite difficult, making initial seeding vital. “It’s akin to changing an English garden into a rainforest,” comments Amati, who also serves as the head nutritionist for the Zoe health app.

So how can we foster the ideal growing environment? The gut microbiome begins to flourish even before birth. Bacteria and fungi present in the uterus are consumed by the fetus, and additional microorganisms are transferred during passage through the vaginal canal at birth.

Babies delivered by C-section generally have different gut bacteria, linked to a heightened risk of asthma and eczema, though these discrepancies typically diminish by 6 to 9 months of age.

The advantages of breastfeeding are even more pronounced, as breast milk contains sugars that promote the growth of beneficial bacteria like Bifidobacterium, which is absent in formula. If we liken the microbiome to a garden, these bacteria act as a protective barrier against harmful microbes.

Antibiotics can severely disrupt early microbiome seeding, eliminating both beneficial and harmful bacteria. While antibiotics are often essential, it is crucial for healthcare providers to prescribe them judiciously to safeguard the developing gut, states James Kinross, a colorectal surgeon at Imperial College London.

Post the first year, dietary choices have the most significant impact. Amati emphasizes that variety is crucial, stemming from whole foods rather than ultra-processed snacks commonly provided to young children.

As many parents are aware, young children are notoriously picky eaters. “Prenatal meals are simply a luxury,” explains pediatrician Nancy Bostock, who highlighted that young children don’t need extensive amounts of food. Persistence is key afterward; “Make 20 offers,” she advises. I implemented this approach and despite initial refusal, I continued to serve salmon every Monday for half a year, and my children now love it.

Introducing whole foods doesn’t have to break the bank either. “Canned lentils and frozen raspberries are excellent choices,” adds Amati.

The benefits of getting dirty

Is there a simple and overlooked way to enhance early microbial diversity? Embrace dirt! Research indicates that soil, plant, and human microbiomes are more interconnected than previously understood.

Kinross states that healthy, undisturbed soil is teeming with microorganisms that support the growth of nutrient-dense food for our microbiome. “Our health is inherently linked to the well-being of our soil. The soil microbiome shapes our food, which subsequently influences our health,” he notes.

Additionally, it appears that interacting with soil might directly introduce beneficial microorganisms into the gut, potentially enhancing immune function. Research on the Amish community, for instance, reveals that those who practice traditional farming methods exhibited stronger immune systems compared to Hutterite groups that utilize industrial agriculture. In animal studies, inhaling dust from Amish households (but not from Hutterite homes) showed protective effects against asthma through enhanced microbial immune signaling.

Families who garden together also show seasonal variations in intestinal soil bacteria, implying that microorganisms are introduced via home-grown produce or direct soil contact. Although the long-term influence on children’s microbiomes is still unclear, various studies indicate that families engaging in gardening tend to have greater microbial diversity and higher nutritional quality than those who do not.

You don’t even need a garden to reap these benefits. Spending time outdoors, tending to potted plants, and consuming home-grown produce are all advantageous for your microbiome, according to Amati.

It’s essential not to conflate getting dirty with the outdated “hygiene hypothesis,” which erroneously attributes inflammatory diseases to maintaining a clean home. What we truly require is exposure to beneficial microorganisms, rather than childhood illnesses that can be minimized by proper hygiene.

The old friend hypothesis suggests that humans evolved alongside beneficial microbes from soil, animals, and each other. Changes in our behavior have diminished contact with these beneficial organisms, potentially contributing to the rise of chronic diseases by reducing outdoor activity.

Promoting healthy dietary habits for your child’s mental well-being

Even after the crucial first 1,000 days, the microbiome remains malleable. That’s why fostering a passion for healthy foods in children is crucial, asserts Amati.

Bostock, who specializes in pediatric mental health including eating disorders, warns against limiting specific foods. “Repeatedly, I observe parents struggling to get their kids to eat certain things unless they consume this or that,” she notes. Emphasizing “good” versus “bad” foods can promote eating disorders and obesity, she asserts.

Instead, she advocates for continuous exposure to a range of foods, shared family meals, and celebrating the unique benefits of each food item (whether it be quick energy or bone-strengthening properties).

Lastly, Amati encourages educating children about their microbiome, stating, “Help them understand the role of these beneficial bugs. They find it fascinating and enjoy nourishing the good bacteria.”

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Source: www.newscientist.com

Astronomers Capture Direct Images of Brown Dwarfs Orbiting Nearby Red Dwarfs

Astronomers utilized the Subaru Telescope, W.M. Keck Observatory, and ESA’s Gaia mission to capture images of the brown dwarf companion orbiting the M dwarf star LSPM J1446+4633.



NIRC2 image of J1446 taken in August 2023. The white arrow indicates the location of the new companion J1446B. Image provided by: Uyama et al., doi: 10.3847/1538-3881/ae08b6.

LSPM J1446+4633 (J1446) is a nearby mid-M dwarf, situated 17 parsecs (55 light-years) away.

The newly identified brown dwarf orbits its parent star at a distance approximately 4.3 times that of the Earth from the sun, completing an orbit every 20 years.

This object, designated J1446B, has a mass ranging from 20 to 60 times that of Jupiter.

“The success of this discovery was due to the combination of three complementary observational methods: (i) radial velocity (RV) measurements via long-term infrared spectroscopic monitoring by Subaru’s IRD instrument, (ii) high-resolution near-infrared imaging with advanced adaptive optics at the W.M. Keck Observatory, and (iii) precise astronomical acceleration measurements from ESA’s Gaia mission,” stated California State University astronomer Taichi Uyama and his team.

“By integrating these datasets and applying Kepler’s laws, we were able to determine the dynamic mass and orbital parameters of J1446B with unprecedented precision.”

“Radial velocity data by itself cannot differentiate between mass and orbital inclination, but the addition of direct imaging and Gaia data resolves this ambiguity.”

“The Subaru IRD-SSP program provided crucial RV data, while Keck’s cutting-edge adaptive optics allowed for the direct detection of the companion star at very close distances from the host star.”

“Previous studies have shown that astronomical acceleration from Hipparcos and Gaia can be combined with direct imaging to detect and analyze companion objects.”

“However, Hipparcos was unable to measure faint red dwarf stars like J1446.”

“Our study is the first to apply Gaia-only acceleration data to such a system, successfully constraining the orbit and dynamical mass of a brown dwarf companion.”

Near-infrared observations of J1446B indicated a brightness variation of about 30%, hinting at dynamic atmospheric phenomena such as clouds or storms.

“This finding serves as a significant benchmark for testing brown dwarf formation theories and atmospheric models,” the astronomers noted.

“Future spectroscopic studies may enable researchers to map the weather patterns on this intriguing object.”

“This achievement highlights the efficacy of combining ground-based and space-based observatories in discovering hidden worlds beyond our solar system.”

The team’s paper was published in Astronomy Magazine.

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Taichi Uyama et al. 2025. Direct Image Exploration for Companions with Subaru/IRD Strategic Program II. A brown dwarf companion star was discovered around the nearby medium-M dwarf LSPM J1446+4633. A.J. 170, 272; doi: 10.3847/1538-3881/ae08b6

Source: www.sci.news

Scientists Suggest Total Solar Eclipse May Prompt Dawn Behavior in Birds

On April 8, 2024, a total solar eclipse interrupted the daylight cycles of North American birds as they prepared for spring breeding. Researchers at Indiana University, after analyzing over 10,000 community observations and utilizing artificial intelligence to examine nearly 100,000 bird calls, discovered that bird behavior was significantly impacted by the few minutes of unexpected afternoon darkness. More than half of the bird species altered their biological rhythms, leading many to produce dawn choruses in the aftermath of the eclipse.



Circles indicate individual observations from the SolarBird app submitted on April 8, 2024. Image courtesy of Aguilar et al., doi: 10.1126/science.adx3025.

The daily and seasonal rhythms of birds are closely regulated by variations in light and darkness.

What occurs when these cycles are abruptly disrupted, such as during a total solar eclipse?

Previous research has explored the effects of solar eclipses on animal behavior, yet many studies have only provided scattered or anecdotal insights regarding animal responses.

Indiana University researcher Liz Aguilar and her team viewed the total solar eclipse in April 2024 as a unique research opportunity, offering an unprecedented natural experiment to observe how birds react to sudden light changes.

In preparation for the solar eclipse that would cast nearly four minutes of darkness over large regions of the central and eastern United States, they developed a smartphone app called SolarBird, which allows users to document bird behaviors in real time during the eclipse.

The citizen scientists’ contributions resulted in almost 10,000 observations spanning 5,000 km along the eclipse’s path.

Simultaneously, researchers deployed autonomous recording devices across southern Indiana to capture the calls of about 100,000 birds before, during, and after the totality.

These recordings were analyzed using BirdNet, an AI system capable of identifying species calls and measuring vocal activity.

Findings revealed that 29 out of 52 species detected exhibited significant changes in their singing behavior at various points during the event, although the eclipse’s effects varied among species.

In the moments leading up to the eclipse, 11 species were found to sing more than usual as darkness approached.

During the four minutes of darkness, 12 species reacted—some becoming silent, while others increased their vocal activity.

The most notable responses were observed after the sun re-emerged, with 19 species adjusting their songs to mimic a false dawn chorus.

Notably, barred owls hooted four times more frequently than usual, while robins—renowned for their pre-dawn melodies—hooted six times more than normal.

“These patterns indicate that the solar eclipse temporarily reset the internal clocks of certain birds, causing them to act as if a new day had commenced,” the researchers stated.

Their paper was published in the October 9, 2025 edition of the journal Science.

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Liz A. Aguilar et al. 2025. Total solar eclipses trigger dawn behavior in birds: Insights from acoustic recordings and crowd science. Science 390 (6769): 152-155; doi: 10.1126/science.adx3025

Source: www.sci.news

Antidepressants Can Cause a Diverse Range of Physical Side Effects.

Different individuals may respond better to certain antidepressants based on their side effects.

Maria Vekulenko/Getty Images

The side effects of antidepressants can differ significantly, ranging from weight fluctuations to alterations in blood pressure. Medical professionals need to consider these factors when selecting the most appropriate medication among the numerous options available.

About 10% of individuals in Europe and the US utilize antidepressants to address symptoms including depression and anxiety. Withdrawal symptoms may not be as prevalent as assumed, yet some studies indicate physical side effects associated with these medications. The specific side effects linked to each drug, however, remain unclear.

Diving deeper into the research, Toby Pillinger and his team from King’s College London examined data from 151 randomized controlled trials and 17 reports from the US Food and Drug Administration. These studies encompassed 30 different antidepressants, assessing their efficacy and side effects relative to a placebo over roughly eight weeks for various mental health conditions.

“The strength of these studies lies in their placebo-controlled and randomized design, allowing us to confidently attribute the observed differences to the medications,” Pillinger states.

The analysis revealed that certain medications were linked to weight loss, while others caused weight gain. For instance, maprotiline was associated with an average weight gain of approximately 1.8 kg, whereas agomelatine was linked to an average weight loss of about 2.4 kg.

The research additionally indicated that fluvoxamine led to an average decrease in heart rate of 8 beats per minute (bpm), while nortriptyline raised it by 13 bpm. Notably, nortriptyline also lowered systolic blood pressure (the pressure during heart contractions) by 3 to 7 millimeters of mercury (mmHg), whereas doxepin elevated blood pressure by nearly 5 mmHg, which may have wider health implications. “For every 1 mmHg increase in blood pressure, the risk of stroke rises by 1%,” remarks Oliver Howes, also from King’s College London.

Other medications like paroxetine, duloxetine, desvenlafaxine, and venlafaxine have been linked to increased cholesterol levels. It remains uncertain if these side effects intensify, diminish, or stabilize after the initial eight-week period.

Although observational studies have raised concerns regarding the potential impact of antidepressants on electrolyte levels, particularly sodium—as it may influence heart rhythms—”our study indicates that sodium isn’t an issue at all,” Pillinger comments.

In the UK, over 92 million antidepressants were prescribed last year, with approximately 85% being either sertraline, mirtazapine, fluoxetine, amitriptyline, citalopram, or venlafaxine. Among these, four exhibited relatively favorable profiles for various evaluated factors; however, amitriptyline was noted for increasing body weight, heart rate, and blood pressure, while venlafaxine was found to elevate heart rate, blood pressure, and cholesterol levels.

“This information is immensely useful for both physicians and patients,” remarks Mahyar Etminan from Epilytics, an epidemiological consulting firm in Vancouver. “This data can be integrated into an application, enabling doctors to identify which medications to avoid for individuals with high cholesterol or cardiovascular issues. It provides physicians with greater flexibility in selecting the most suitable antidepressant for their patients.”

Pillinger mentions that his team is developing a digital tool that features a drop-down list of common side effects associated with antidepressants, assisting healthcare providers in determining which medications to avoid or whether reducing dosage could be advantageous. “The essential goal is to find the most appropriate drug for each individual and tailor prescriptions accordingly,” Pillinger explains.

However, John Ioannidis, a researcher at Stanford University, cautions that their findings could be skewed if only studies demonstrating side effects were included. Some research may not have reported any adverse effects, thus excluding pertinent data from the meta-analysis.

He also points out that patients typically remain on antidepressants for at least eight weeks, often for several years. “If such an impact exists over a more extended period, it necessitates different long-term studies to validate its relevance,” Ioannidis asserts.

Pillinger acknowledges the possibility of bias but believes they have compiled the majority of relevant data. He recognizes the need for long-term study analysis and is in the process of conducting it, mentioning that around 75% of trial participants have been white. Nonetheless, he believes the trends identified will likely become clearer over extended studies and may extend to other demographics.

Prior research has indicated that some antidepressants, such as venlafaxine, are associated with long-term blood pressure increases. He also notes that rapid weight gain might persist. “Once weight is gained, it becomes challenging to lose it again,” he states.

However, due to the effectiveness of antidepressants, those worried about side effects should not discontinue their medication, according to Howes. “This is a nuanced issue and an individual decision that considers your unique risk factors and benefits. If concerned, consulting with your physician is advisable.”

Topic:

  • Medical drugs /
  • Depression

Source: www.newscientist.com

ALMA Observes Spiral Gas Streamers Controlled by Magnetic Fields in Star-Forming Areas

This stream of gas transports material from the clouds surrounding the star-forming area within Perseus directly into an emerging binary star system known as SVS 13A.

Artist’s impression of the SVS 13A system. Image credit: NSF/AUI/NSF’s NRAO/P.Vosteen.

Stars are formed from clouds of gas and dust, and recent observations indicate that the process of star formation is far more dynamic than previously understood.

New findings from the Atacama Large Millimeter/Submillimeter Array (ALMA) reveal both dust and molecules swirling around the SVS 13A system. This data shows how the magnetic field not only permeates these stellar nurseries but actively directs the flow of matter, offering a preferred path for gas to accumulate in the disk where new stars and planets arise.

“Visualize a garden hose, but instead of water, it smoothly channels materials for star formation through intricate pathways carved by unseen forces,” explains Dr. Paulo Cortes, an astronomer at the NSF National Radio Astronomy Observatory and the joint ALMA telescope.

“This perspective from ALMA observations presents channels of gas known as subalfvénic streamers, regulated by spiral magnetic field lines.”

“This new data provides an insightful glimpse into the star formation process.”

“These streamers illustrate how magnetic fields can influence star formation by managing material influx, akin to a private highway facilitating car travel.”

ALMA’s images and findings uncover two spiral arms of dust encircling the star, with gas streams closely mirroring the same trajectory.

This remarkable configuration implies that the gas within the streamer is traversing at a slower pace than previously believed, reinforcing the concept of a magnetized channel rather than a chaotic, collapsing cloud.

The presence of such streamers, linking clouds to disks and supplying them with material in a managed fashion, indicates that both gravity and magnetism are crucial in the formation of stars and the shaping of potential planetary bodies around them.

This groundbreaking result signifies the first instance where astronomers have directly mapped both a streamer and its associated magnetic field in a single observation.

“Subalfvenic streamers indicate a fresh role for magnetic fields amidst gravitational dominance, acting as ‘guides’ to assist the descent of material from the outer envelope to the disk,” the astronomers remarked.

Upcoming findings are detailed in a paper in the Astrophysics Journal Letter.

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PC Cortez et al. 2025. First results from ALPPS: SVS 13A subalfvenic streamer. APJL 992, L31; doi: 10.3847/2041-8213/ae0c04

Source: www.sci.news

Elon Musk Responds Rashly After NASA Reveals Plans to Source Lunar Lander from SpaceX Competitor

NASA’s Acting Administrator Sean Duffy seems to have drawn the ire of Elon Musk.

Elon Musk, founder and CEO of SpaceX, took to social media on Tuesday to criticize Mr. Duffy’s intelligence and recent actions as the leader of the space agency.

“Sean Dummy is trying to destroy NASA!” Musk stated on X, using a derogatory nickname for the acting administrator. In another post, he remarked: “There’s no way the leader of America’s space program can have a double-digit IQ.”

On Monday, Duffy announced that NASA is considering utilizing a lunar lander from a SpaceX competitor to help return astronauts to the moon before China establishes its presence there.

NASA initially planned to use SpaceX’s next-generation Starship rocket system for the lunar landing.

Musk conducted a poll on Tuesday asking his followers on X: “Should someone whose greatest achievement is climbing trees lead America’s space program?” One option was, “Yes, chimpanzees are good at it!” while the other suggested, “No, he needs More Brains!”

By Tuesday afternoon, the poll had garnered around 110,000 votes.

In 2021, SpaceX secured a $2.9 billion contract to use its Starship rocket to land two astronauts on the moon during NASA’s Artemis III mission, aimed for a 2027 launch.

However, Musk’s company has faced delays in the testing and development of Starship, which experienced several explosions this year.

Meanwhile, political pressure is mounting as the competition with China escalates; the nation is targeting a moon landing by 2030 and has already dispatched two robotic probes and tested a new rocket for manned lunar missions.

Duffy appeared on Fox News and CNBC on Monday, stating that NASA would expand the Artemis III contract, inviting proposals from rival space companies to maintain U.S. competitiveness against China.

“We are not going to wait for a single company,” Duffy reiterated in an appearance on CNBC’s “Squawk Box.” on Monday. “We are focused on moving forward and winning the second space race against China.”

Duffy mentioned his and President Donald Trump’s goal to return astronauts to the moon during Trump’s second term.

He cited Blue Origin, the space launch company founded by Jeff Bezos, as a potential competitor capable of providing unique technology.

This statement appeared to antagonize Musk.

In a subsequent post, Musk questioned the ability of other commercial space firms to meet such stringent deadlines.

“In comparison to other space industries, SpaceX is advancing at remarkable speed,” he asserted. “Moreover, Starship will ultimately execute the full lunar mission. Mark my words.”

In reality, SpaceX is so ahead of its rivals that it is already conducting regular NASA missions to transport astronauts and cargo to the International Space Station.

Reacting to Musk’s remarks, Duffy replied on X: “Love the enthusiasm. The race to the moon is on. Great companies should welcome challenges. Competition among innovators benefits America!”

However, Musk’s tirade on Tuesday took a personal turn, questioning Duffy’s competence to lead NASA. Duffy is temporarily in charge of the agency; a Wall Street Journal report suggested he is positioning himself to continue in that role alongside his responsibilities as transportation secretary.

The report indicated that Duffy is contending against billionaire Jared Isaacman, who may reemerge as a candidate for the NASA leadership position. Trump had retracted Isaacman’s nomination in May, just ahead of an anticipated confirmation vote. This withdrawal followed what the president described as a “thorough review of prior connections.” (Trump did not elaborate, but some Republicans had expressed reservations that Isaacman previously donated to Democrats.)

Musk has shown support for Isaacman, who has made two orbital flights on commercial SpaceX missions.

NASA spokesperson Bethany Stevens informed NBC News that President Trump has asked Duffy to consult with potential administrators, and that the interim administrator “will be glad to assist by evaluating candidates and providing honest feedback.”

“Sean is thankful to the president for this opportunity to lead NASA,” Stevens stated. “At the president’s direction, Sean is committed to ensuring America returns to the moon before China. He has indicated that NASA’s integration into the Cabinet, possibly even the Department of Transportation, might be beneficial, though he has never claimed he wishes to continue in this role.”

The White House did not respond to inquiries for comment.

The timing of Isaacman’s controversy in May coincided with a public feud between Trump and Musk, which escalated before the SpaceX CEO departed the White House on a special public service assignment. Musk’s departure was fraught with tension as he criticized President Trump’s “One Big Beautiful Bill,” labeling it a “huge, outrageous, pig-filled Congressional spending plan” and a “distasteful, ugly bill” that would exacerbate the budget deficit.

playing cards We welcomed Duffy in July. Becomes interim administrator of NASA.

Source: www.nbcnews.com

Exclusive: Climate Scientists Anticipate Solar Dimming Efforts by 2100

Solar geoengineering aims to block some sunlight.

PA Images/Alamy

A study by top climate scientists projects that by the end of this century, humanity will undertake significant measures to block sunlight as a desperate effort to safeguard Earth’s population from the escalating impacts of climate change, as reported by New Scientist.

“Solar geoengineering is a troubling concept, yet it is becoming more appealing as global efforts to reduce greenhouse gas emissions fall short,” stated a respondent from Victoria University of Wellington, James Renwick.

According to the study, two-thirds of participants anticipate hazardous interventions will be employed to manage the atmosphere by the year 2100. Alarmingly, 52% believe these actions could be taken by irresponsible entities, including private firms, wealthy individuals, and nation-states, highlighting fears that attempts to cool the climate may proceed without comprehensive global governance to address decision-making or mitigate inherent risks.

“The potential for unintended consequences, political misuse, and abrupt climate impacts remains substantial,” a respondent remarked. Ines Camilloni of the University of Buenos Aires, Argentina, noted these concerns.


New Scientist invited around 800 climate researchers, contributors to the Intergovernmental Panel on Climate Change’s (IPCC) latest report, to participate in an anonymous online survey concerning solar geoengineering. The 120 respondents represented diverse academic fields from all continents, yielding one of the most extensive insights into the climate science community’s stance on solar geoengineering so far.

Since the 1960s, scientists have been exploring ways to enhance Earth’s albedo—the reflectivity of the planet—for a procedure known as solar geoengineering or solar radiation modification (SRM).

Cooling strategies might include the injection of particles into the upper atmosphere to reflect sunlight away from Earth, known as stratospheric aerosol injection. Another suggestion involves introducing salt particles into low-altitude ocean clouds, referred to as ocean cloud brightening (see “How does solar geoengineering operate?” below).

Solar geoengineering may involve injecting sea salt into ocean clouds.

San Francisco Chronicle/Yalonda M. James/eyevine

68% of respondents indicated that due to the global failure to reduce greenhouse gas emissions over the last decade, the likelihood of deploying such measures has increased. “It reflects a growing realization that we are not addressing climate change effectively,” noted Sean Fitzgerald from the Center for Climate Change Remediation at the University of Cambridge. “What options do we have? We may not prefer them, but if we disapprove of the current situation, we must consider alternatives.”

While consensus exists regarding the potential for solar geoengineering, experts disagree on the triggers for such drastic measures. Just over 20% of respondents believe these measures should be considered should global temperatures be on track to rise more than 2°C above pre-industrial levels, a scenario that is becoming increasingly likely with global warming surpassing the 1.5°C mark. Others argued that waiting for more extreme warming would be wiser, while over half felt current warming levels were insufficient to warrant serious consideration of atmospheric alteration.

Such actions could theoretically help lower global temperatures and provide time for emissions reductions, yet nearly all respondents recognized substantial risks associated with widespread implementation, including diminished motivation to cut emissions, disruption to vital agricultural rainfall patterns, and abrupt warming due to “termination shock” should these interventions cease.

The study further highlighted concerns regarding unilateral climate interventions by nations or individuals, with 81% of respondents agreeing that a new international treaty or framework is necessary to regulate all large-scale deployments, marking a significant consensus across the survey questions.

These findings reflect a cautious stance, according to Andy Parker from the Degrees Initiative. “This is a global technology. No nation can opt out of a geoengineered world. Similarly, no nation can choose to ignore a warmer world if geoengineering is rejected.”

Growing Interest in Geoengineering

New Scientist decided to undertake this research as interest in solar geoengineering grows amid escalating climate impacts. Hundreds of millions of dollars in funding are flowing into this area, with researchers presenting their findings at scientific forums, building a global research community. Earlier this year, the UK Government allocated £57 million in grants for solar geoengineering research via the Advanced Research and Inventions Agency (ARIA), supporting small-scale field experiments.

This represents a significant pivot for a field traditionally sidelined within climate science. Daniele Visioni has led numerous SRM modeling projects at Cornell University in New York. “This topic has transitioned from being loosely discussed by a small group of scholars to becoming a global issue.”

Just over one-third of the respondents from New Scientist‘s survey asserted that due to humanity’s ongoing struggle to cut emissions, they now support SRM research, albeit not necessarily its implementation. A notable 49% are in favor of conducting small-scale outdoor experiments to better understand the associated risks and benefits.

Accelerated cloud cooling could lead to drought in East Africa.

Fadel Senna/AFP via Getty Images

“There is growing acceptance of the necessity of SRM research,” Parker states, tying it directly to the increased pessimism surrounding climate change outcomes.

“Given that most surveyed experts believe solar radiation management is probable within the next century, we must collect comprehensive real-world data regarding the feasibility and potential impacts of these cooling strategies,” asserts Mark Symes, director of ARIA’s Climate Cooling Program.

However, support is by no means unanimous, with approximately 45% of respondents deeming this a contentious or taboo research area. A third opposed outdoor experimentation with any countermeasures, and 11% refrained from contributing to solar geoengineering studies to protect their professional reputation.

“Many of these climate scientists see that the initial vision of climate science—to heed the warnings of the Earth and reduce emissions—has failed,” according to Visioni.

Much hesitance regarding solar geoengineering stems from the multitude of potentially catastrophic risks associated with large-scale sunlight-reflecting efforts.

Almost all respondents noted that implementation might dampen motivation to reduce emissions as one of the most critical risks. Other significant threats included social and political unrest, severe disruptions to agriculture and food security, harm to delicate ecosystems, and public health crises. “Modifying the entire climate system through SRM is a considerable risk,” cautioned Shreekant Gupta at the Center for Social and Economic Progress in Delhi, India.

For instance, research indicates that enhancing cloud cooling effects over the Indian Ocean could mitigate droughts in North Africa while triggering droughts in East Africa. Additional studies suggest that aerosol injections into the stratosphere could damage the ozone layer and potentially reduce monsoon rainfall in parts of Africa by up to 20%.

However, the ambiguity of “unknown consequences” emerged as the most commonly mentioned risk. One survey participant pointed out that “human efforts to rectify damaged systems have often met with limited success.”

Three primary techniques for solar geoengineering include:

1. Stratospheric aerosol injection
This technique involves dispersing tiny liquid particles called aerosols from high-altitude aircraft to reflect sunlight. Over 60% of survey respondents identified this as the method most likely to be adopted.

2. Thinning of cirrus clouds
This method utilizes aerosols such as nitric acid to thin cirrus clouds, permitting more heat to escape into space. However, excessive aerosol spraying can thicken clouds and produce the opposite effect. Only a minority of respondents believed this method or land-based strategies for enhancing global albedo could be pursued.

3. Brightening ocean clouds
This approach involves spraying minute seawater droplets onto clouds, enhancing their brightness and increasing sunlight reflection. It was trialed in a small experiment in 2024 aimed at protecting the Great Barrier Reef. Approximately 16% of respondents felt this technique would likely be adopted.

topic:

Source: www.newscientist.com

Saturn’s Moon Titan Could Harbor an Unforeseen Blend of Hydrogen Cyanide and Hydrocarbons

Titan serves as an intriguing subject for in-depth investigations of organic chemistry under unusual conditions. This Saturnian moon is abundant in nonpolar hydrocarbons like ethane and methane, alongside hydrogen cyanide (HCN), a highly relevant small polar molecule in prebiotic chemistry. Recent studies show that these notably polar compounds can mix at low temperatures, creating structures that challenge traditional chemical theories.

Artistic rendering of Kraken Mare, Titan’s extensive ocean of liquid methane. Image credit: NASA’s John Glenn Research Center.

Hydrogen cyanide is commonly found in the astrochemical landscape and has been detected in numerous celestial bodies, including the interstellar medium, comets, planets, moons, and dwarf planets.

This molecule ranks as the second most prevalent product anticipated from Titan’s atmospheric chemistry.

Dr. Martin Rahm, a researcher from Chalmers University of Technology, stated: “These remarkable discoveries enhance our understanding of something vast—a moon comparable in size to Mercury.”

In laboratory experiments, Rahm and his team combined hydrogen cyanide with methane and ethane at temperatures as low as 90 K (around -180 degrees Celsius).

At this temperature, hydrogen cyanide forms crystals, while methane and ethane exist as liquids.

Using laser spectroscopy to analyze these mixtures at an atomic level, researchers found that while the molecules remained intact, changes were still occurring.

To uncover what was happening, they conducted extensive computer simulations to explore thousands of potential molecular arrangements in the solid phase.

Ultimately, they discovered that the hydrocarbons infiltrated the hydrogen cyanide crystal lattice, leading to the formation of a stable new structure termed a cocrystal.

“The identification of unexpected interactions between these substances may influence our understanding of Titan’s geology and unique features such as lakes, oceans, and sand dunes,” Dr. Rahm explained.

“Moreover, hydrogen cyanide could be crucial in the abiotic synthesis of some life-building blocks, like amino acids for proteins and nucleobases for genetic material.”

“Consequently, our research offers valuable insights into the pre-emergent chemistry of life and the potential for life to evolve in extreme environments.”

of result Published in July 2025. Proceedings of the National Academy of Sciences.

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Fernando Izquierdo Ruiz and others. 2025. Hydrogen cyanide and hydrocarbons mix on Titan. PNAS 122 (30): e2507522122; doi: 10.1073/pnas.2507522122

Source: www.sci.news